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Whether it functions in all locations as a glutamate transporter, or mainly as a glutamate-gated chloride conductance, remains to be determined. 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2.3.1.-", "protein_names_refseq": "diacylglycerol O-acyltransferase 2-like protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:678749); (R-RNO-1482883)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006640 monoacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTG7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTQ7-1", "uniprot_id": [ { "id": "D3ZTQ7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTQ7", "type": "external" } ], "mass": 34815.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or8i2", "organism": "Rat", "refseq_name": "olfactory receptor Olr536", "refseq_ac": [ { "id": "NP_001000564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000564", "type": "external" } ], "gene_names_uniprotkb": "Or8i2", "gene_names_refseq": "Olr536; Or8i2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 536; olfactory receptor Olr536; olfactory receptor gene Olr536", "tax_id": 10116, "disease": "", "pathway": " (rno:366103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTZ5-1", "uniprot_id": [ { "id": "D3ZTZ5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTZ5", "type": "external" } ], "mass": 54619.0, "length": 492, "protein_name": "BPI fold containing family B, member 5", "gene_name": "Bpifb5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bpifb5", "gene_names_refseq": "", "protein_names_uniprotkb": "BPI fold containing family B, member 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTZ5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU21-1", "uniprot_id": [ { "id": "D3ZU21_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU21", "type": "external" } ], "mass": 89793.0, "length": 757, "protein_name": "Progesterone immunomodulatory binding factor 1", "gene_name": "Pibf1", "organism": "Rat", "refseq_name": "progesterone-induced-blocking factor 1", "refseq_ac": [ { "id": "NP_001292348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292348", "type": "external" } ], "gene_names_uniprotkb": "Pibf1", "gene_names_refseq": "Pibf1; 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Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G protein complexes to ADORA2A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0001725 stress fiber", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007026 negative regulation of microtubule depolymerization;GO:0051764 actin crosslink formation;GO:0060296 regulation of cilium beat frequency involved in ciliary motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUE4-1", "uniprot_id": [ { "id": "D3ZUE4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUE4", "type": "external" } ], "mass": 61165.0, "length": 536, "protein_name": "Suppressor of cytokine signaling 5", "gene_name": "Socs5", "organism": "Rat", "refseq_name": "suppressor of cytokine signaling 5", "refseq_ac": [ { "id": "NP_001102744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102744", "type": "external" } ], "gene_names_uniprotkb": "Socs5", "gene_names_refseq": "RGD1564914; Socs5", "protein_names_uniprotkb": "Suppressor of cytokine signaling 5", "protein_names_refseq": "suppressor of cytokine signaling 5", "tax_id": 10116, "disease": "", "pathway": " (rno:500616); (R-RNO-6785807); (R-RNO-8951664)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17464217;19176113", "class_list": "", "function": "These results suggest that activated Stat3 binds to SOCS promoters and leads to their transcriptional induction., [RefSeq, PubMed]; Up-regulation of SOCS5 may have protective functions in experimental autoimmune uveoretinitis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUG8-1", "uniprot_id": [ { "id": "D3ZUG8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUG8", "type": "external" } ], "mass": 26989.0, "length": 237, "protein_name": "Ferritin", "gene_name": "Ftmt", "organism": "Rat", "refseq_name": "ferritin, mitochondrial", "refseq_ac": [ { "id": "NP_001099606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099606", "type": "external" } ], "gene_names_uniprotkb": "Ftmt", "gene_names_refseq": "Ftmt", "protein_names_uniprotkb": "Ferritin", "protein_names_refseq": "ferritin, mitochondrial", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:291470); (R-RNO-917937)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18726999;33594527;39168410", "class_list": "", "function": "FTMT-dependent mitophagy is crucial for ferroptosis resistance in cardiac fibroblast., [RefSeq, PubMed]; Ferritin contributes to apoptosis in primary epatocytes in an autocrine, density dependent mode, involving Fas stimulation and proapoptotic mitochondrial signalling., [RefSeq, PubMed]; Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis., [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008198 ferrous iron binding;GO:0004322 ferroxidase activity;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZUG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUM4-1", "uniprot_id": [ { "id": "D3ZUM4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUM4", "type": "external" } ], "mass": 73228.0, "length": 647, "protein_name": "Beta-galactosidase", "gene_name": "Glb1", "organism": "Rat", "refseq_name": "beta-galactosidase precursor", "refseq_ac": [ { "id": "NP_001101662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101662", "type": "external" } ], "gene_names_uniprotkb": "Glb1", "gene_names_refseq": "Glb1", "protein_names_uniprotkb": "Beta-galactosidase; 3.2.1.23", "protein_names_refseq": "beta-galactosidase precursor; beta-galactosidase", "tax_id": 10116, "disease": "GM1 gangliosidosis type 3 (Disease Ontology:DOID:0080489); GM1 gangliosidosis type 2 (Disease Ontology:DOID:0080501); GM1 gangliosidosis type 1 (Disease Ontology:DOID:0080502); mucopolysaccharidosis type IVB (Disease Ontology:DOID:0111392); mucopolysaccharidosis IV (Disease Ontology:DOID:12804); GM1 gangliosidosis (Disease Ontology:DOID:3322)", "pathway": " (rno:316033); (R-RNO-2022857); (R-RNO-2024101); (R-RNO-4085001); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "16641100;29393594;32423114;38843836", "class_list": "", "function": "A Novel Protocol for Detection of Senescence and Calcification Markers by Fluorescence Microscopy. Publication Status: Online-Only, [RefSeq, PubMed]; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.18", "url": 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"https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": 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"https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0016936 galactoside binding;GO:0004565 beta-galactosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome;GO:0005773 vacuole", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0005975 carbohydrate metabolic process;GO:0019388 galactose catabolic process;GO:0042340 keratan sulfate proteoglycan catabolic process;GO:0051413 response to cortisone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZUM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUR5-1", "uniprot_id": [ { "id": "D3ZUR5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUR5", "type": "external" } ], "mass": 10637.0, "length": 97, "protein_name": "Secreted Ly-6/uPAR domain-containing protein 2", "gene_name": "Slurp2", "organism": "Rat", "refseq_name": "secreted Ly-6/uPAR domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001124023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124023", "type": "external" } ], "gene_names_uniprotkb": "Slurp2; RGD1308195", "gene_names_refseq": "RGD1308195; Slurp2", "protein_names_uniprotkb": "Secreted Ly-6/uPAR domain-containing protein 2", "protein_names_refseq": "secreted Ly-6/uPAR domain-containing protein 2 precursor; secreted Ly-6/uPAR domain-containing protein 2", "tax_id": 10116, "disease": "palmoplantar keratosis (Disease Ontology:DOID:3390)", "pathway": " (rno:315074)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0043616 keratinocyte proliferation;GO:0099601 regulation of neurotransmitter receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUR5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZV32-1", "uniprot_id": [ { "id": "D3ZV32_RAT", "url": "https://www.uniprot.org/uniprot/D3ZV32", "type": "external" } ], "mass": 86900.0, "length": 790, "protein_name": "Solute carrier family 26 member 9", "gene_name": "Slc26a9", "organism": "Rat", "refseq_name": "solute carrier family 26 member 9", "refseq_ac": [ { "id": "NP_001100642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100642", "type": "external" } ], "gene_names_uniprotkb": "Slc26a9", "gene_names_refseq": "Slc26a9", "protein_names_uniprotkb": "Solute carrier family 26 member 9", "protein_names_refseq": "solute carrier family 26 (anion exchanger), member 9; solute carrier family 26 member 9", "tax_id": 10116, "disease": "gastrointestinal system disease (Disease Ontology:DOID:77)", "pathway": " (rno:304784); (R-RNO-427601)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23933130", "class_list": "", "function": "Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0005254 chloride channel activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0015701 bicarbonate transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZV32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZV34-1", "uniprot_id": [ { "id": "D3ZV34_RAT", "url": "https://www.uniprot.org/uniprot/D3ZV34", "type": "external" } ], "mass": 35010.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or6c8", "organism": "Rat", "refseq_name": "olfactory receptor Olr878", "refseq_ac": [ { "id": "NP_001000497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000497", "type": "external" } ], "gene_names_uniprotkb": "Or6c8; OR6c8; Olr878", "gene_names_refseq": "Olr878; Or6c8", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 878; olfactory receptor Olr878; olfactory receptor gene Olr878", "tax_id": 10116, "disease": "", "pathway": " (rno:304610)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZV34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZV88-1", "uniprot_id": [ { "id": "D3ZV88_RAT", "url": "https://www.uniprot.org/uniprot/D3ZV88", "type": "external" } ], "mass": 36134.0, "length": 333, "protein_name": "Zinc finger protein 444", "gene_name": "Zfp444", "organism": "Rat", "refseq_name": "zinc finger protein 444", "refseq_ac": [ { "id": "NP_001162614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162614", "type": "external" } ], "gene_names_uniprotkb": "Zfp444", "gene_names_refseq": "Zfp444; Znf444", "protein_names_uniprotkb": "Zinc finger protein 444", "protein_names_refseq": "zinc finger protein 444", "tax_id": 10116, "disease": "", "pathway": " (rno:292569)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZV88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVP9-1", "uniprot_id": [ { "id": "D3ZVP9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVP9", "type": "external" } ], "mass": 97021.0, "length": 862, "protein_name": "Solute carrier family 4 member 11", "gene_name": "Slc4a11", "organism": "Rat", "refseq_name": "solute carrier family 4 member 11", "refseq_ac": [ { "id": "NP_001101245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101245", "type": "external" } ], "gene_names_uniprotkb": "Slc4a11", "gene_names_refseq": "Slc4a11", "protein_names_uniprotkb": "Solute carrier family 4 member 11; Sodium borate cotransporter 1", "protein_names_refseq": "sodium bicarbonate transporter-like protein 11; solute carrier family 4 member 11; solute carrier family 4, sodium bicarbonate transporter-like, member 11; solute carrier family 4, sodium borate transporter, member 11", "tax_id": 10116, "disease": "congenital hereditary endothelial dystrophy of cornea (Disease Ontology:DOID:0060649); corneal dystrophy-perceptive deafness syndrome (Disease Ontology:DOID:0111620); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:311423)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26582474;31124301", "class_list": "", "function": "SLC4A11 is expressed relatively more abundantly in collecting ducts of the lower inner medulla where it is involved in ammonia recycling., [RefSeq, PubMed]; We conclude that SLC4A11 is a rare integral membrane protein in which the CD has strong associations with the integral MD, which contributes to membrane transport function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046983 protein dimerization activity;GO:0015293 symporter activity;GO:0005372 water transmembrane transporter activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0012506 vesicle membrane", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0055085 transmembrane transport;GO:0051881 regulation of mitochondrial membrane potential;GO:0034599 cellular response to oxidative stress;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZVP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVR9-1", "uniprot_id": [ { "id": "PGM5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVR9", "type": "external" } ], "mass": 62204.0, "length": 567, "protein_name": "Phosphoglucomutase-like protein 5", "gene_name": "Pgm5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pgm5", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoglucomutase-like protein 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570)", "pathway": " (rno:679990)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;7890770", "class_list": "", "function": "Component of adherens-type cell-cell and cell-matrix junctions (By similarity). Positively regulates maturation and alignment of myofibrils, also promotes organization of sarcomeres (By similarity). Has no phosphoglucomutase activity in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016868 intramolecular phosphotransferase activity;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0014704 intercalated disc", "go_biological_process": "GO:0014706 striated muscle tissue development;GO:0007155 cell adhesion;GO:0005975 carbohydrate metabolic process;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZVR9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVY5-1", "uniprot_id": [ { "id": "D3ZVY5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVY5", "type": "external" } ], "mass": 22556.0, "length": 209, "protein_name": "Deleted in lymphocytic leukemia, 7", "gene_name": "Dleu7", "organism": "Rat", "refseq_name": "leukemia-associated protein 7", "refseq_ac": [ { "id": "NP_001387927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387927", "type": "external" } ], "gene_names_uniprotkb": "Dleu7", "gene_names_refseq": "Dleu7; RGD1305071", "protein_names_uniprotkb": "Deleted in lymphocytic leukemia, 7", "protein_names_refseq": "leukemia-associated protein 7", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVY5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVZ0-1", "uniprot_id": [ { "id": "D3ZVZ0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVZ0", "type": "external" } ], "mass": 35274.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or5p6b", "organism": "Rat", "refseq_name": "olfactory receptor Olr247", "refseq_ac": [ { "id": "NP_001000217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000217", "type": "external" } ], "gene_names_uniprotkb": "Or5p6b", "gene_names_refseq": "Olr247; Or5p6b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 247; olfactory receptor Olr247; olfactory receptor gene Olr247", "tax_id": 10116, "disease": "", "pathway": " (rno:293392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZW36-1", "uniprot_id": [ { "id": "D3ZW36_RAT", "url": "https://www.uniprot.org/uniprot/D3ZW36", "type": "external" } ], "mass": 34808.0, "length": 314, "protein_name": "Olfactory receptor family 10 subfamily D member 4C", "gene_name": "Or10d4c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or10d4c; Olr1311", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily D member 4C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300610)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZW36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZW92-1", "uniprot_id": [ { "id": "D3ZW92_RAT", "url": "https://www.uniprot.org/uniprot/D3ZW92", "type": "external" } ], "mass": 32068.0, "length": 283, "protein_name": "Family with sequence similarity 78, member A", "gene_name": "Fam78a", "organism": "Rat", "refseq_name": "protein FAM78A", "refseq_ac": [ { "id": "NP_001386392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386392", "type": "external" } ], "gene_names_uniprotkb": "Fam78a", "gene_names_refseq": "Fam78a; RGD1566351", "protein_names_uniprotkb": "Family with sequence similarity 78, member A", "protein_names_refseq": "protein FAM78A", "tax_id": 10116, "disease": "", "pathway": " (rno:499776)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZW92-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWE1-1", "uniprot_id": [ { "id": "D3ZWE1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWE1", "type": "external" } ], "mass": 38198.0, "length": 360, "protein_name": "Aspartate beta-hydroxylase domain containing 1", "gene_name": "Asphd1", "organism": "Rat", "refseq_name": "aspartate beta-hydroxylase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001386952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386952", "type": "external" } ], "gene_names_uniprotkb": "Asphd1; RGD1306636", "gene_names_refseq": "Asphd1; RGD1306636", "protein_names_uniprotkb": "Aspartate beta-hydroxylase domain containing 1", "protein_names_refseq": "aspartate beta-hydroxylase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:293498)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051213 dioxygenase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWM1-1", "uniprot_id": [ { "id": "D3ZWM1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWM1", "type": "external" } ], "mass": 53615.0, "length": 488, "protein_name": "Cis-aconitate decarboxylase", "gene_name": "Acod1", "organism": "Rat", "refseq_name": "cis-aconitate decarboxylase", "refseq_ac": [ { "id": "NP_001100752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100752", "type": "external" } ], "gene_names_uniprotkb": "Acod1; Irg1", "gene_names_refseq": "Acod1; Irg1; RGD1563454", "protein_names_uniprotkb": "Cis-aconitate decarboxylase; 4.1.1.6; Aconitate decarboxylase 1; Aconitate decarboxylase; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein", "protein_names_refseq": "cis-aconitate decarboxylase; immunoresponsive 1 homolog; immunoresponsive gene 1", "tax_id": 10116, "disease": "esophageal carcinoma (Disease Ontology:DOID:1107); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520)", "pathway": " (rno:306127)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0047613 aconitate decarboxylase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002760 positive regulation of antimicrobial humoral response;GO:0034136 negative regulation of toll-like receptor 2 signaling pathway;GO:0071393 cellular response to progesterone stimulus;GO:0072573 tolerance induction to lipopolysaccharide;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWM1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWM3-1", "uniprot_id": [ { "id": "D3ZWM3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWM3", "type": "external" } ], "mass": 96157.0, "length": 868, "protein_name": "G protein-coupled receptor 155", "gene_name": "Gpr155", "organism": "Rat", "refseq_name": "lysosomal cholesterol signaling protein", "refseq_ac": [ { "id": "NP_001101281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101281", "type": "external" } ], "gene_names_uniprotkb": "Gpr155", "gene_names_refseq": "Gpr155", "protein_names_uniprotkb": "G protein-coupled receptor 155", "protein_names_refseq": "integral membrane protein GPR155; 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2.3.1.256; N-acetyltransferase 12; N-acetyltransferase MAK3 homolog; NatC catalytic subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. 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"id": "NP_001000851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000851", "type": "external" } ], "gene_names_uniprotkb": "Or2f1b", "gene_names_refseq": "Olr807; Or2f1b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 807; olfactory receptor Olr807; olfactory receptor gene Olr807", "tax_id": 10116, "disease": "", "pathway": " (rno:405141)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Kiaa0408L; Soga3", "gene_names_refseq": "9330159F19Rikl; Kiaa0408L; Kiaa0408; RGD1307525; Rgd1310049; Soga3", "protein_names_uniprotkb": "Kiaa0408-like", "protein_names_refseq": "Kiaa0408-like; SOGA family member 3; uncharacterized protein KIAA0408 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYL2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYP7-1", "uniprot_id": [ { "id": "D3ZYP7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYP7", "type": "external" } ], "mass": 51637.0, "length": 459, "protein_name": "DNA polymerase subunit gamma-2", "gene_name": "Polg2", "organism": "Rat", "refseq_name": "DNA polymerase subunit gamma-2, mitochondrial", "refseq_ac": [ { "id": "NP_001100530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100530", "type": "external" } ], "gene_names_uniprotkb": "Polg2", "gene_names_refseq": "Polg2", "protein_names_uniprotkb": "DNA polymerase subunit gamma-2; DNA polymerase gamma accessory 55 kDa subunit; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta", "protein_names_refseq": "DNA polymerase subunit gamma-2, mitochondrial; polymerase (DNA directed), gamma 2, accessory subunit; polymerase (DNA) gamma 2, accessory subunit", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 16 (Disease Ontology:DOID:0070446); mitochondrial DNA depletion syndrome 16B (Disease Ontology:DOID:0070447); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 (Disease Ontology:DOID:0111525); nephrocalcinosis (Disease Ontology:DOID:12679)", "pathway": " (rno:303612); (R-RNO-9913635)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003887 DNA-directed DNA polymerase activity;GO:0042802 identical protein binding;GO:0070182 DNA polymerase binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0005760 gamma DNA polymerase complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007005 mitochondrion organization;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006264 mitochondrial DNA replication;GO:0032042 mitochondrial DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYP7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYT2-1", "uniprot_id": [ { "id": "D3ZYT2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYT2", "type": "external" } ], "mass": 48136.0, "length": 432, "protein_name": "Small ribosomal subunit protein uS5m", "gene_name": "Mrps5", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS5m", "refseq_ac": [ { "id": "NP_001099975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099975", "type": "external" } ], "gene_names_uniprotkb": "Mrps5", "gene_names_refseq": "Mrps5", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5m; 28S ribosomal protein S5, mitochondrial", "protein_names_refseq": "28S ribosomal protein S5, mitochondrial; small ribosomal subunit protein uS5m", "tax_id": 10116, "disease": "", "pathway": " (rno:296134); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYT2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZ42-1", "uniprot_id": [ { "id": "D3ZZ42_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZ42", "type": "external" } ], "mass": 65431.0, "length": 568, "protein_name": "Matrix metalloproteinase-21", "gene_name": "Mmp21", "organism": "Rat", "refseq_name": "matrix metalloproteinase-21 precursor", "refseq_ac": [ { "id": "NP_001099778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099778", "type": "external" } ], "gene_names_uniprotkb": "Mmp21", "gene_names_refseq": "Mmp21", "protein_names_uniprotkb": "Matrix metalloproteinase-21", "protein_names_refseq": "matrix metalloproteinase 21; matrix metalloproteinase-21 precursor", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 7 (Disease Ontology:DOID:0051021)", "pathway": " (rno:293573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18633436", "class_list": "", "function": "MMP-21 may be an important protease in the terminal differentiation of keratinocytes, [RefSeq, PubMed]; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Or2y14", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1397; olfactory receptor Olr1397; olfactory receptor gene Olr1397", "tax_id": 10116, "disease": "", "pathway": " (rno:405988)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport., [UniProtKB, UniProtKB]; Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor., [RefSeq, PubMed]; The unique distribution pattern of gene OA1 product GPR143 in the rat central nervous system central nervous system, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0035643 L-DOPA receptor activity;GO:0035240 dopamine binding;GO:0072544 L-DOPA binding;GO:0072545 L-tyrosine binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0032438 melanosome organization;GO:0032402 melanosome transport;GO:0032400 melanosome localization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A092-1", "uniprot_id": [ { "id": "D4A092_RAT", "url": "https://www.uniprot.org/uniprot/D4A092", "type": "external" } ], "mass": 20705.0, "length": 191, "protein_name": "Vesicle-associated membrane protein-associated protein A", "gene_name": "Mospd4", "organism": "Rat", "refseq_name": "motile sperm domain containing 4", "refseq_ac": [ { "id": "NP_001101711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101711", "type": "external" } ], "gene_names_uniprotkb": "Mospd4", "gene_names_refseq": "Mospd4", "protein_names_uniprotkb": "Vesicle-associated membrane protein-associated protein A", "protein_names_refseq": "motile sperm domain containing 4", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 8 (Disease Ontology:DOID:0050752); autosomal dominant adult-onset proximal spinal muscular atrophy (Disease Ontology:DOID:0111194); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:317161)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A092-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0F4-1", "uniprot_id": [ { "id": "D4A0F4_RAT", "url": "https://www.uniprot.org/uniprot/D4A0F4", "type": "external" } ], "mass": 17589.0, "length": 158, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000065703", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000065703; ENSRNOG00000065453; LOC134482030", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6AGM0;D3ZJ60", "ec_number_list": [], "go_molecular_function": "GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0F4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0J0-1", "uniprot_id": [ { "id": "D4A0J0_RAT", "url": "https://www.uniprot.org/uniprot/D4A0J0", "type": "external" } ], "mass": 45064.0, "length": 400, "protein_name": "WD repeat and FYVE domain containing 2", "gene_name": "Wdfy2", "organism": "Rat", "refseq_name": "WD repeat and FYVE domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001402031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402031", "type": "external" } ], "gene_names_uniprotkb": "Wdfy2", "gene_names_refseq": "Wdfy2", "protein_names_uniprotkb": "WD repeat and FYVE domain containing 2", "protein_names_refseq": "WD repeat and FYVE domain-containing protein 2 isoform 2; WD repeat and FYVE domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:305956)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0031982 vesicle", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0J0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0J7-1", "uniprot_id": [ { "id": "D4A0J7_RAT", "url": "https://www.uniprot.org/uniprot/D4A0J7", "type": "external" } ], "mass": 83706.0, "length": 748, "protein_name": "Olfactomedin-like 2B", "gene_name": "Olfml2b", "organism": "Rat", "refseq_name": "olfactomedin-like protein 2B isoform X1", "refseq_ac": [ { "id": "XP_006250281", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006250281", "type": "external" } ], "gene_names_uniprotkb": "Olfml2b", "gene_names_refseq": "Olfml2b", "protein_names_uniprotkb": "Olfactomedin-like 2B", "protein_names_refseq": "olfactomedin-like protein 2B isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007165 signal transduction;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0J7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0T0-1", "uniprot_id": [ { "id": "D4A0T0_RAT", "url": "https://www.uniprot.org/uniprot/D4A0T0", "type": "external" } ], "mass": 20859.0, "length": 176, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "gene_name": "Ndufb10", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "refseq_ac": [ { "id": "NP_001102913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102913", "type": "external" } ], "gene_names_uniprotkb": "Ndufb10", "gene_names_refseq": "Ndufb10", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; 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Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A0T0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0T9-1", "uniprot_id": [ { "id": "D4A0T9_RAT", "url": "https://www.uniprot.org/uniprot/D4A0T9", "type": "external" } ], "mass": 154652.0, "length": 1425, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13", "gene_name": "Adamts13", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4", "refseq_ac": [ { "id": "XP_038962061", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038962061", "type": "external" } ], "gene_names_uniprotkb": "Adamts13", "gene_names_refseq": "Adamts13", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 13; 3.4.24.87; von Willebrand factor-cleaving protease", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4", "tax_id": 10116, "disease": "hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); HELLP syndrome (Disease Ontology:DOID:13133); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:102554393); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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LOC691952", "gene_names_refseq": "Terb2", "protein_names_uniprotkb": "Telomere repeat binding bouquet formation protein 2", "protein_names_refseq": "telomere repeats-binding bouquet formation protein 2; uncharacterized protein C15orf43 homolog", "tax_id": 10116, "disease": "spermatogenic failure 59 (Disease Ontology:DOID:0112357)", "pathway": " (rno:691952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1L6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1T4-1", "uniprot_id": [ { "id": "D4A1T4_RAT", "url": "https://www.uniprot.org/uniprot/D4A1T4", "type": "external" } ], "mass": 9118.0, "length": 82, "protein_name": "Cortexin 2", "gene_name": "Ctxn2", "organism": "Rat", "refseq_name": "cortexin-2", "refseq_ac": [ { "id": "NP_001156407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156407", "type": "external" } ], "gene_names_uniprotkb": "Ctxn2", "gene_names_refseq": "Ctxn2", "protein_names_uniprotkb": "Cortexin 2", "protein_names_refseq": "cortexin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:100302373)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1T4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1V6-1", "uniprot_id": [ { "id": "D4A1V6_RAT", "url": "https://www.uniprot.org/uniprot/D4A1V6", "type": "external" } ], "mass": 65595.0, "length": 612, "protein_name": "T-box transcription factor 18", "gene_name": "Tbx18", "organism": "Rat", "refseq_name": "T-box transcription factor TBX18", "refseq_ac": [ { "id": "NP_001101643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101643", "type": "external" } ], "gene_names_uniprotkb": "Tbx18", "gene_names_refseq": "Tbx18", "protein_names_uniprotkb": "T-box transcription factor 18", "protein_names_refseq": "T-box transcription factor TBX18; 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RGD1562710", "protein_names_uniprotkb": "Neuromedin B", "protein_names_refseq": "neuromedin-B isoform X1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:499194); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031710 neuromedin B receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043005 neuron projection", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1W6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1X2-1", "uniprot_id": [ { "id": "EXOSX_RAT", "url": "https://www.uniprot.org/uniprot/D4A1X2", "type": "external" } ], "mass": 100719.0, "length": 885, "protein_name": "Exosome complex component 10", "gene_name": "Exosc10", "organism": "Rat", "refseq_name": "exosome complex component 10", "refseq_ac": [ { "id": "NP_001386158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386158", "type": "external" } ], "gene_names_uniprotkb": "Exosc10", "gene_names_refseq": "Exosc10; PM/Scl100", "protein_names_uniprotkb": "Exosome complex component 10; 3.1.13.-", "protein_names_refseq": "exosome complex component 10", "tax_id": 10116, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:313707); (R-RNO-6791226); (R-RNO-9930044)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29118343", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA (By similarity). Plays a role in the recruitment of replication protein A complex (RPA) and RAD51 to DNA double-strand breaks caused by irradiation, contributing to DNA repair by homologous recombination (By similarity). Regulates levels of damage-induced RNAs in order to prevent DNA-RNA hybrid formation at DNA double-strand breaks and limit DNA end resection after damage (By similarity). Plays a role in oocyte development, maturation and survival (By similarity). Required for normal testis development and mitotic division of spermatogonia (By similarity). Plays a role in proper embryo development (By similarity). Required for global protein translation (By similarity). Required for cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0006281 DNA repair;GO:0006396 RNA processing;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1X2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1Y2-1", "uniprot_id": [ { "id": "D4A1Y2_RAT", "url": "https://www.uniprot.org/uniprot/D4A1Y2", "type": "external" } ], "mass": 31343.0, "length": 278, "protein_name": "Tumor protein p63 regulated 1", "gene_name": "Tprg1", "organism": "Rat", "refseq_name": "tumor protein p63-regulated gene 1 protein", "refseq_ac": [ { "id": "NP_001101790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101790", "type": "external" } ], "gene_names_uniprotkb": "Tprg1", "gene_names_refseq": "RGD1306226; Svap30; Tprg1; Tprg", "protein_names_uniprotkb": "Tumor protein p63 regulated 1", "protein_names_refseq": "synaptic vesicle associated protein of 30 kD; transformation related protein 63 regulated; tumor protein p63-regulated gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360731)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1Y2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2B8-1", "uniprot_id": [ { "id": "D4A2B8_RAT", "url": "https://www.uniprot.org/uniprot/D4A2B8", "type": "external" } ], "mass": 70627.0, "length": 619, "protein_name": "Long-chain-fatty-acid--CoA ligase", "gene_name": "Slc27a6", "organism": "Rat", "refseq_name": "long-chain fatty acid transport protein 6", "refseq_ac": [ { "id": "NP_001099615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099615", "type": "external" } ], "gene_names_uniprotkb": "Slc27a6", "gene_names_refseq": "Slc27a6", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase; 6.2.1.3; 6.2.1.7", "protein_names_refseq": "long-chain fatty acid transport protein 6-like; long-chain fatty acid transport protein 6; solute carrier family 27 (fatty acid transporter), member 6", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:291582); (R-RNO-804914)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047747 cholate-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0044539 long-chain fatty acid import into cell;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2B8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2I4-1", "uniprot_id": [ { "id": "D4A2I4_RAT", "url": "https://www.uniprot.org/uniprot/D4A2I4", "type": "external" } ], "mass": 21564.0, "length": 192, "protein_name": "ORMDL sphingolipid biosynthesis regulator 2", "gene_name": "Ormdl2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ormdl2", "gene_names_refseq": "", "protein_names_uniprotkb": "ORMDL sphingolipid biosynthesis regulator 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:288783); (R-RNO-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2I4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2J8-1", "uniprot_id": [ { "id": "D4A2J8_RAT", "url": "https://www.uniprot.org/uniprot/D4A2J8", "type": "external" } ], "mass": 35182.0, "length": 311, "protein_name": "Olfactory receptor family 6 subfamily C member 214", "gene_name": "Or6c214", "organism": "Rat", "refseq_name": "olfactory receptor Olr1051", "refseq_ac": [ { "id": "NP_001001364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001364", "type": "external" } ], "gene_names_uniprotkb": "Or6c214", "gene_names_refseq": "Olr1051; Or6c214", "protein_names_uniprotkb": "Olfactory receptor family 6 subfamily C member 214", "protein_names_refseq": "olfactory receptor 1051; olfactory receptor Olr1051; olfactory receptor gene Olr1051", "tax_id": 10116, "disease": "", "pathway": " (rno:288839)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2J8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A321-1", "uniprot_id": [ { "id": "D4A321_RAT", "url": "https://www.uniprot.org/uniprot/D4A321", "type": "external" } ], "mass": 140542.0, "length": 1228, "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16", "gene_name": "Dhx38", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dhx38", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; 3.6.4.13; ATP-dependent RNA helicase DHX38; DEAH box protein 38", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinitis pigmentosa 84 (Disease Ontology:DOID:0112141)", "pathway": " (R-RNO-159236); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" 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Zc3hdc1", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP12; ADP-ribosyltransferase diphtheria toxin-like 12; Poly [ADP-ribose] polymerase 12; Zinc finger CCCH domain-containing protein 1", "protein_names_refseq": "poly ADP-ribose polymerase 12; protein mono-ADP-ribosyltransferase PARP12; zinc finger CCCH type domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005802 trans-Golgi network;GO:0010494 cytoplasmic stress granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0070633 transepithelial transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3V3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3X3-1", "uniprot_id": [ { "id": "D4A3X3_RAT", "url": "https://www.uniprot.org/uniprot/D4A3X3", "type": "external" } ], "mass": 18225.0, "length": 161, "protein_name": "Ubiquitin-like protein ISG15", "gene_name": "Isg15", "organism": "Rat", "refseq_name": "ubiquitin-like protein ISG15", "refseq_ac": [ { "id": "NP_001100170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100170", "type": "external" } ], "gene_names_uniprotkb": "Isg15", "gene_names_refseq": "G1p2; Isg15", "protein_names_uniprotkb": "Ubiquitin-like protein ISG15; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; Ubiquitin cross-reactive protein", "protein_names_refseq": "interferon, alpha-inducible protein (clone IFI-15K); ubiquitin-like protein ISG15", "tax_id": 10116, "disease": "immunodeficiency 38 (Disease Ontology:DOID:0111934)", "pathway": " (rno:298693); (R-RNO-1169408); (R-RNO-5656169); (R-RNO-9833482); (R-RNO-9909505)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "30826466", "class_list": "", "function": "The data revealed that maternal immune activation impedes offspring's dendrite development and causes depressive like behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0007229 integrin-mediated signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A3X3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3X7-1", "uniprot_id": [ { "id": "D4A3X7_RAT", "url": "https://www.uniprot.org/uniprot/D4A3X7", "type": "external" } ], "mass": 65250.0, "length": 574, "protein_name": "Sorting nexin", "gene_name": "Snx33", "organism": "Rat", "refseq_name": "sorting nexin-33", "refseq_ac": [ { "id": "NP_001120960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120960", "type": "external" } ], "gene_names_uniprotkb": "Snx33", "gene_names_refseq": "Sh3px3; Snx33", "protein_names_uniprotkb": "Sorting nexin", "protein_names_refseq": "SH3 and PX domain containing 3; sorting nexin-33", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:315696)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3X7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A416-1", "uniprot_id": [ { "id": "D4A416_RAT", "url": "https://www.uniprot.org/uniprot/D4A416", "type": "external" } ], "mass": 62290.0, "length": 539, "protein_name": "Lipid scramblase CLPTM1L", "gene_name": "Clptm1l", "organism": "Rat", "refseq_name": "lipid scramblase CLPTM1L", "refseq_ac": [ { "id": "NP_001101710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101710", "type": "external" } ], "gene_names_uniprotkb": "Clptm1l", "gene_names_refseq": "Clptm1l; RGD1307896", "protein_names_uniprotkb": "Lipid scramblase CLPTM1L; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1-like protein", "protein_names_refseq": "cleft lip and palate transmembrane protein 1-like protein; lipid scramblase CLPTM1L", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pharynx squamous cell carcinoma (Disease Ontology:DOID:0050921); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:316916)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A416-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A427-1", "uniprot_id": [ { "id": "D4A427_RAT", "url": "https://www.uniprot.org/uniprot/D4A427", "type": "external" } ], "mass": 8376.0, "length": 74, "protein_name": "Anaphase-promoting complex subunit 13", "gene_name": "Anapc13", "organism": "Rat", "refseq_name": "anaphase-promoting complex subunit 13", "refseq_ac": [ { "id": "NP_001167454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167454", "type": "external" } ], "gene_names_uniprotkb": "Anapc13", "gene_names_refseq": "Anapc13", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 13; Cyclosome subunit 13", "protein_names_refseq": "anaphase-promoting complex subunit 13", "tax_id": 10116, "disease": "", "pathway": " (rno:685029); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0141198 protein branched polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A427-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A463-1", "uniprot_id": [ { "id": "D4A463_RAT", "url": "https://www.uniprot.org/uniprot/D4A463", "type": "external" } ], "mass": 32520.0, "length": 303, "protein_name": "Tubulin polyglutamylase complex subunit 1", "gene_name": "Tpgs1", "organism": "Rat", "refseq_name": "tubulin polyglutamylase complex subunit 1", "refseq_ac": [ { "id": "NP_001103091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103091", "type": "external" } ], "gene_names_uniprotkb": "Tpgs1", "gene_names_refseq": "Gtrgeo22; PGs1; Tpgs1", "protein_names_uniprotkb": "Tubulin polyglutamylase complex subunit 1", "protein_names_refseq": "gene trap ROSA b-geo 22; tubulin polyglutamylase complex subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:691093)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12972506;22673903", "class_list": "", "function": "Isolation and functional characterization of the mouse PGs1 ortholog, and comparison to the rat protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0045202 synapse;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0030534 adult behavior;GO:0007268 chemical synaptic transmission;GO:0018095 protein polyglutamylation;GO:0007288 sperm axoneme assembly;GO:0051648 vesicle localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A463-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4J1-1", "uniprot_id": [ { "id": "D4A4J1_RAT", "url": "https://www.uniprot.org/uniprot/D4A4J1", "type": "external" } ], "mass": 51908.0, "length": 470, "protein_name": "Inhibitory synaptic factor 2A", "gene_name": "Insyn2a", "organism": "Rat", "refseq_name": "inhibitory synaptic factor 2A", "refseq_ac": [ { "id": "NP_001137275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137275", "type": "external" } ], "gene_names_uniprotkb": "Insyn2a; Fam196a; Insyn2", "gene_names_refseq": "Fam196a; Insyn2a; Insyn2", "protein_names_uniprotkb": "Inhibitory synaptic factor 2A", "protein_names_refseq": "family with sequence similarity 196, member A; inhibitory synaptic factor 2A; protein FAM196A", "tax_id": 10116, "disease": "", "pathway": " (rno:100233213)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0098982 GABA-ergic synapse;GO:0099572 postsynaptic specialization", "go_biological_process": "GO:0060080 inhibitory postsynaptic potential;GO:0099565 chemical synaptic transmission, postsynaptic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4J1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4K5-1", "uniprot_id": [ { "id": "D4A4K5_RAT", "url": "https://www.uniprot.org/uniprot/D4A4K5", "type": "external" } ], "mass": 25740.0, "length": 237, "protein_name": "Synapse differentiation inducing 1-like", "gene_name": "Syndig1l", "organism": "Rat", "refseq_name": "synapse differentiation-inducing gene protein 1-like", "refseq_ac": [ { "id": "NP_001102955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102955", "type": "external" } ], "gene_names_uniprotkb": "Syndig1l", "gene_names_refseq": "Syndig1l; Tmem90a", "protein_names_uniprotkb": "Synapse differentiation inducing 1-like", "protein_names_refseq": "capucin; synapse differentiation-inducing gene protein 1-like; transmembrane protein 90A", "tax_id": 10116, "disease": "", "pathway": " (rno:685882)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4K5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4M8-1", "uniprot_id": [ { "id": "D4A4M8_RAT", "url": "https://www.uniprot.org/uniprot/D4A4M8", "type": "external" } ], "mass": 35889.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "Or8k24", "organism": "Rat", "refseq_name": "olfactory receptor Olr496", "refseq_ac": [ { "id": "NP_001000681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000681", "type": "external" } ], "gene_names_uniprotkb": "Or8k24", "gene_names_refseq": "Olr496; Or8k24", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 496; olfactory receptor 8K3-like; olfactory receptor Olr496; olfactory receptor gene Olr496", "tax_id": 10116, "disease": "", "pathway": " (rno:404885)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A4M8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4V7-1", "uniprot_id": [ { "id": "D4A4V7_RAT", "url": "https://www.uniprot.org/uniprot/D4A4V7", "type": "external" } ], "mass": 73527.0, "length": 666, "protein_name": "Zinc finger protein 282", "gene_name": "Zfp282", "organism": "Rat", "refseq_name": "zinc finger protein 282", "refseq_ac": [ { "id": "NP_001100062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100062", "type": "external" } ], "gene_names_uniprotkb": "Zfp282", "gene_names_refseq": "Zfp282; Znf282", "protein_names_uniprotkb": "Zinc finger protein 282", "protein_names_refseq": "zinc finger protein 282", "tax_id": 10116, "disease": "", "pathway": " (rno:297065); (R-RNO-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A511-1", "uniprot_id": [ { "id": "D4A511_RAT", "url": "https://www.uniprot.org/uniprot/D4A511", "type": "external" } ], "mass": 10137.0, "length": 86, "protein_name": "Signal recognition particle 9 kDa protein", "gene_name": "Srp9", "organism": "Rat", "refseq_name": "signal recognition particle 9 kDa protein", "refseq_ac": [ { "id": "NP_001119567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119567", "type": "external" } ], "gene_names_uniprotkb": "Srp9", "gene_names_refseq": "Srp9", "protein_names_uniprotkb": "Signal recognition particle 9 kDa protein; SRP9", "protein_names_refseq": "signal recognition particle 9 kDa protein", "tax_id": 10116, "disease": "", "pathway": " (rno:690345); (R-RNO-1799339)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008312 7S RNA binding", "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005829 cytosol", "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0045900 negative regulation of translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A511-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A520-1", "uniprot_id": [ { "id": "D4A520_RAT", "url": "https://www.uniprot.org/uniprot/D4A520", "type": "external" } ], "mass": 32847.0, "length": 307, "protein_name": "Protein phosphatase", "gene_name": "Pptc7", "organism": "Rat", "refseq_name": "protein phosphatase PTC7 homolog", "refseq_ac": [ { "id": "NP_001100611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100611", "type": "external" } ], "gene_names_uniprotkb": "Pptc7", "gene_names_refseq": "Pptc7; RGD1310383", "protein_names_uniprotkb": "Protein phosphatase; 3.1.3.16", "protein_names_refseq": "PTC7 protein phosphatase homolog; T-cell activation protein phosphatase 2C; protein phosphatase PTC7 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:304488)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis. Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous. May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability. Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0010795 regulation of ubiquinone biosynthetic process;GO:1904775 positive regulation of ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A520-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5C0-1", "uniprot_id": [ { "id": "D4A5C0_RAT", "url": "https://www.uniprot.org/uniprot/D4A5C0", "type": "external" } ], "mass": 60805.0, "length": 549, "protein_name": "Nectin-3", "gene_name": "Nectin3", "organism": "Rat", "refseq_name": "nectin-3 isoform 1", "refseq_ac": [ { "id": "NP_001386157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386157", "type": "external" } ], "gene_names_uniprotkb": "Nectin3; Pvrl3", "gene_names_refseq": "Nectin3; Pvrl3", "protein_names_uniprotkb": "Nectin-3; Nectin cell adhesion molecule 3; Poliovirus receptor-related protein 3", "protein_names_refseq": "nectin-3 isoform 1; nectin-3; poliovirus receptor-related 3; poliovirus receptor-related protein 3", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "25232752;27044745;27217376;28176461", "class_list": "", "function": "MMP-9 has a role in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioral alterations Publication Status: Online-Only, [RefSeq, PubMed]; Nectin-3 is increased in the cell junctions of the uterine epithelium at implantation. Results suggest that at the time of implantation, nectin-3 may contribute to the formation of the tight junction in a protein complex independent from occludin and l-afadin., [RefSeq, PubMed]; PDZD11 forms a complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif of nectin-1., [RefSeq, PubMed]; Spermatid junction molecule that is internalized by adjacent Sertoli cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007155 cell adhesion;GO:0009566 fertilization;GO:0098609 cell-cell adhesion;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A5C0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5J1-1", "uniprot_id": [ { "id": "D4A5J1_RAT", "url": "https://www.uniprot.org/uniprot/D4A5J1", "type": "external" } ], "mass": 67849.0, "length": 633, "protein_name": "Kelch repeat and BTB domain containing 11", "gene_name": "Kbtbd11", "organism": "Rat", "refseq_name": "kelch repeat and BTB domain-containing protein 11", "refseq_ac": [ { "id": "NP_001100796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100796", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd11", "gene_names_refseq": "Kbtbd11; RGD1563576", "protein_names_uniprotkb": "Kelch repeat and BTB domain containing 11", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 11; kelch repeat and BTB domain-containing protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:306617)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A5J1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5P8-1", "uniprot_id": [ { "id": "D4A5P8_RAT", "url": "https://www.uniprot.org/uniprot/D4A5P8", "type": "external" } ], "mass": 14721.0, "length": 137, "protein_name": "WAP four-disulfide core domain 3", "gene_name": "Wfdc3", "organism": "Rat", "refseq_name": "WAP four-disulfide core domain protein 3 precursor", "refseq_ac": [ { "id": "NP_001100011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100011", "type": "external" } ], "gene_names_uniprotkb": "Wfdc3", "gene_names_refseq": "Wfdc3", "protein_names_uniprotkb": "WAP four-disulfide core domain 3", "protein_names_refseq": "WAP four-disulfide core domain protein 3 precursor; WAP four-disulfide core domain protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:296366)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A5P8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5Q2-1", "uniprot_id": [ { "id": "D4A5Q2_RAT", "url": "https://www.uniprot.org/uniprot/D4A5Q2", "type": "external" } ], "mass": 134280.0, "length": 1191, "protein_name": "Structural maintenance of chromosomes protein", "gene_name": "Smc2", "organism": "Rat", "refseq_name": "structural maintenance of chromosomes protein 2", "refseq_ac": [ { "id": "NP_001102136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102136", "type": "external" } ], "gene_names_uniprotkb": "Smc2", "gene_names_refseq": "CAP-E; CAPE; Smc2l1; Smc2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein", "protein_names_refseq": "SMC2 structural maintenance of chromosomes 2-like 1; chromosome-associated protein E; structural maintenance of chromosomes protein 2", "tax_id": 10116, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:362519); (R-RNO-2299718); (R-RNO-2514853)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10958694", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB, UniProtKB]; Demonstrates that the human Smc2l1 ortholog, hCAP-E, is a member of the condensin complex that is involved in mitotic chromosome condensation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051383 kinetochore organization;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A5Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5Z0-1", "uniprot_id": [ { "id": "D4A5Z0_RAT", "url": "https://www.uniprot.org/uniprot/D4A5Z0", "type": "external" } ], "mass": 62654.0, "length": 542, "protein_name": "Hexosyltransferase", "gene_name": "Csgalnact2", "organism": "Rat", "refseq_name": "chondroitin sulfate N-acetylgalactosaminyltransferase 2", "refseq_ac": [ { "id": "NP_001100086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100086", "type": "external" } ], "gene_names_uniprotkb": "Csgalnact2", "gene_names_refseq": "Csgalnact2; Galnact2; RGD1563660", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "chondroitin sulfate GalNAcT-2; chondroitin sulfate N-acetylgalactosaminyltransferase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:297554); (R-RNO-2022870)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008376 acetylgalactosaminyltransferase activity;GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic 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Required for neuronal activity. Accumulation at the postsynaptic density results in enlargement of dendritic spines., [UniProtKB, UniProtKB]; Observations firmly establish FAM81A protein as a component of the postsynaptic density in the adult brain, suggesting a role in synaptic function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KEU1", "ec_number_list": [], "go_molecular_function": "GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A815-1", "uniprot_id": [ { "id": "D4A815_RAT", "url": "https://www.uniprot.org/uniprot/D4A815", "type": "external" } ], "mass": 19071.0, "length": 164, "protein_name": "Endoribonuclease YbeY", "gene_name": "Ybey", "organism": "Rat", "refseq_name": "endoribonuclease YbeY isoform 1", "refseq_ac": [ { "id": "NP_001421565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421565", "type": "external" } ], "gene_names_uniprotkb": "Ybey", "gene_names_refseq": "RGD1308722; 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Polycystic kidney disease 2-like 2 protein; Polycystin-L2", "protein_names_refseq": "polycystic kidney disease 2-like 2 protein; polycystin-2-like protein 2", "tax_id": 10116, "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:291683)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits a lower single conductance but no spontaneous channel activity. May function as a regulator of calcium channels or a channel component involving Ca2(+) homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A828-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A864-1", "uniprot_id": [ { "id": "D4A864_RAT", "url": "https://www.uniprot.org/uniprot/D4A864", "type": "external" } ], "mass": 71415.0, "length": 622, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "Galnt6", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 6", "refseq_ac": [ { "id": "NP_001165534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165534", "type": "external" } ], "gene_names_uniprotkb": "Galnt6", "gene_names_refseq": "Galnt6", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6); polypeptide N-acetylgalactosaminyltransferase 6", "tax_id": 10116, "disease": "", "pathway": " (rno:100361647); (R-RNO-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.1, "record_id": "D4A864-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A879-1", "uniprot_id": [ { "id": "D4A879_RAT", "url": "https://www.uniprot.org/uniprot/D4A879", "type": "external" } ], "mass": 19744.0, "length": 173, "protein_name": "Ferritin", "gene_name": "4933416E14Rikl", "organism": "Rat", "refseq_name": "uncharacterized protein LOC302536", "refseq_ac": [ { "id": "NP_001100424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100424", "type": "external" } ], "gene_names_uniprotkb": "4933416E14Rikl; 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Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB]; Expression of CPNE6 increased remarkably in brains of epileptic patients and in experimental epileptic rats. Expression is mainly in neurons., [RefSeq, PubMed]; Results provide the first evidence that impaired learning and memory in non-alcoholic fatty liver disease rats was, at least partly, associated with increased plasma nesfatin-1 concentration and decreased copine 6 expression in the hippocampus and prefrontal cortex., [RefSeq, PubMed]; This study demonstrated that the copine-6 regulates BDNF-dependent changes in dendritic spine morphology to promote synaptic plasticity., [RefSeq, PubMed]; We identify copine-6 as a specific regulator of spontaneous neurotransmission, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion;GO:0098974 postsynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D4ACG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACH0-1", "uniprot_id": [ { "id": "D4ACH0_RAT", "url": "https://www.uniprot.org/uniprot/D4ACH0", "type": "external" } ], "mass": 34943.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or51r1", "organism": "Rat", "refseq_name": "olfactory receptor Olr43", "refseq_ac": [ { "id": "NP_001000541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000541", "type": "external" } ], "gene_names_uniprotkb": "Or51r1", "gene_names_refseq": "Olr43; Or51r1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 43; olfactory receptor Olr43; olfactory receptor gene Olr43", "tax_id": 10116, "disease": "", "pathway": " (rno:365322)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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"https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0003707 nuclear steroid receptor activity;GO:0042562 hormone binding;GO:0008126 acetylesterase activity;GO:0120516 diacylglycerol lipase activity", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0097524 sperm plasma membrane", "go_biological_process": "GO:0046464 acylglycerol catabolic process;GO:0007340 acrosome reaction;GO:0032570 response to progesterone;GO:0048240 sperm capacitation;GO:0030336 negative 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In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We showed that the embryo hearts from vitamin A insufficient groups exhibited ultrastructural changes and significantly lowe expression of GATA-4, RARalpha and gamma, and higher expression of RXRalpha and beta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0060429 epithelium development;GO:0002068 glandular epithelial cell development;GO:0060534 trachea cartilage development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZF61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K466-1", "uniprot_id": [ { "id": "A0A0G2K466_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K466", "type": "external" } ], "mass": 34847.0, "length": 310, "protein_name": "Oxidoreductase NAD-binding domain-containing protein 1", "gene_name": "Oxnad1", "organism": "Rat", "refseq_name": "oxidoreductase NAD-binding domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001423614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423614", "type": "external" } ], "gene_names_uniprotkb": "Oxnad1", "gene_names_refseq": "Oxnad1; RGD1311534", "protein_names_uniprotkb": "Oxidoreductase NAD-binding domain-containing protein 1", "protein_names_refseq": "oxidoreductase NAD-binding domain-containing protein 1 isoform 1; oxidoreductase NAD-binding domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:306270)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K466-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4L9P8-1", "uniprot_id": [ { "id": "CE295_RAT", "url": "https://www.uniprot.org/uniprot/A4L9P8", "type": "external" } ], "mass": 269982.0, "length": 2395, "protein_name": "Centrosomal protein of 295 kDa", "gene_name": "Cep295", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cep295", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 295 kDa", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:363018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CPAP- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to-centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centriole disengagement. Binds to and stabilizes centriolar microtubule. May be involved in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:1901985 positive regulation of protein acetylation;GO:1904951 positive regulation of establishment of protein localization;GO:0030030 cell projection organization;GO:0046599 regulation of centriole replication;GO:1903724 positive regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4L9P8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0FKI7-1", "uniprot_id": [ { "id": "ACBD5_RAT", "url": "https://www.uniprot.org/uniprot/A0FKI7", "type": "external" } ], "mass": 56782.0, "length": 506, "protein_name": "Acyl-CoA-binding domain-containing protein 5", "gene_name": "Acbd5", "organism": "Rat", "refseq_name": "acyl-CoA-binding domain-containing protein 5 isoform 1", "refseq_ac": [ { "id": "NP_001071103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071103", "type": "external" } ], "gene_names_uniprotkb": "Acbd5", "gene_names_refseq": "Acbd5", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 5", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 5 isoform 1; acyl-CoA-binding domain-containing protein 5; acyl-Coenzyme A binding domain containing 5", "tax_id": 10116, "disease": "retinal dystrophy with leukodystrophy (Disease Ontology:DOID:0080946); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (rno:307170); (R-RNO-390918); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9603798)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0FKI6;Q3T1K2", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0000425 pexophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0FKI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V928-1", "uniprot_id": [ { "id": "LRP1_RAT", "url": "https://www.uniprot.org/uniprot/G3V928", "type": "external" } ], "mass": 504889.0, "length": 4545, "protein_name": "Prolow-density lipoprotein receptor-related protein 1", "gene_name": "Lrp1", "organism": "Rat", "refseq_name": "prolow-density lipoprotein receptor-related protein 1 precursor", "refseq_ac": [ { "id": "NP_001123962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123962", "type": "external" } ], "gene_names_uniprotkb": "Lrp1", "gene_names_refseq": "LRP-1; Lrp1", "protein_names_uniprotkb": "Prolow-density lipoprotein receptor-related protein 1; LRP-1", "protein_names_refseq": "low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); prolow-density lipoprotein receptor-related protein 1 precursor; prolow-density lipoprotein receptor-related protein 1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); omphalocele (Disease Ontology:DOID:0060327); keratosis pilaris atrophicans (Disease Ontology:DOID:0080751); Alzheimer's disease (Disease Ontology:DOID:10652); gastroschisis (Disease Ontology:DOID:11044); sciatic neuropathy (Disease Ontology:DOID:11446); alcoholic hepatitis (Disease Ontology:DOID:12351); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); myocardial infarction (Disease Ontology:DOID:5844); prostate carcinoma in situ (Disease Ontology:DOID:8634); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:299858); (R-RNO-2168880); (R-RNO-975634)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22673903;24090084;29393594;35446172;35930096;36372121;38843836", "class_list": "", "function": "Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (By similarity). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as a TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Red-light radiation: does it enhance memory by increasing hippocampal LRP-1 and TRPA-1 genes expression?, [RefSeq, PubMed]; The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease., [RefSeq, PubMed]; The protective role of hippocampal LRP1 knockdown involves synaptic plasticity through the promoting microtubule dynamics and activation of Akt/GSK-3beta pathway in depressive rats., [RefSeq, PubMed]", "predicted_glycosites": 39, "predicted_n_glycosites": 38, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 13, "glyco_site_count": 50, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0H1", "ec_number_list": [], "go_molecular_function": "GO:0016964 alpha-2 macroglobulin receptor activity;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0032370 positive regulation of lipid transport;GO:1905167 positive regulation of lysosomal protein catabolic process;GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:1904109 positive regulation of cholesterol import", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "G3V928-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7A7-1", "uniprot_id": [ { "id": "CEP57_RAT", "url": "https://www.uniprot.org/uniprot/B4F7A7", "type": "external" } ], "mass": 57040.0, "length": 499, "protein_name": "Centrosomal protein of 57 kDa", "gene_name": "Cep57", "organism": "Rat", "refseq_name": "centrosomal protein of 57 kDa", "refseq_ac": [ { "id": "NP_001101594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101594", "type": "external" } ], "gene_names_uniprotkb": "Cep57", "gene_names_refseq": "3110002l15rik; Cep57; RGD1309884", "protein_names_uniprotkb": "Centrosomal protein of 57 kDa; Cep57; Translokin", "protein_names_refseq": "centrosomal protein 57kDa; centrosomal protein of 57 kDa; translokin", "tax_id": 10116, "disease": "mosaic variegated aneuploidy syndrome 2 (Disease Ontology:DOID:0080142)", "pathway": " (rno:315423); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "18294141;29393594", "class_list": "", "function": "Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0017134 fibroblast growth factor binding;GO:0043015 gamma-tubulin binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0007286 spermatid development;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B4F7A7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70490-1", "uniprot_id": [ { "id": "ACSM2_RAT", "url": "https://www.uniprot.org/uniprot/O70490", "type": "external" } ], "mass": 64145.0, "length": 572, "protein_name": "Acyl-coenzyme A synthetase ACSM2, mitochondrial", "gene_name": "Acsm1; Acsm2", "organism": "Rat", "refseq_name": "acyl-coenzyme A synthetase ACSM2, mitochondrial", "refseq_ac": [ { "id": "NP_653349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653349", "type": "external" } ], "gene_names_uniprotkb": "Acsm1; Acsm2; Acsm2a; Acsm2; Bucs1; Ks", "gene_names_refseq": "Acsm2a; Acsm2; KS", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM2, mitochondrial; 6.2.1.25; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 2; Benzoate--CoA ligase; Butyrate--CoA ligase 2; Butyryl-coenzyme A synthetase 2; Kidney-specific protein KS; Middle-chain acyl-CoA synthetase 2", "protein_names_refseq": "acyl-CoA synthetase medium-chain family member 2A; acyl-coenzyme A synthetase ACSM2, mitochondrial; benzoate--CoA ligase; butyrate--CoA ligase 2; butyryl-coenzyme A synthetase 2; kidney-specific protein KS; middle-chain acyl-CoA synthetase 2; xenobiotic/medium-chain fatty acid:CoA ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:246263); (R-RNO-177128); (R-RNO-177135); (R-RNO-177162); (R-RNO-9749641)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9844120", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ63", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0102391 decanoate-CoA ligase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0036112 medium-chain fatty-acyl-CoA metabolic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70490-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53987-1", "uniprot_id": [ { "id": "MOT1_RAT", "url": "https://www.uniprot.org/uniprot/P53987", "type": "external" } ], "mass": 53238.0, "length": 494, "protein_name": "Monocarboxylate transporter 1", "gene_name": "Slc16a1", "organism": "Rat", "refseq_name": "monocarboxylate transporter 1", "refseq_ac": [ { "id": "NP_036848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036848", "type": "external" } ], "gene_names_uniprotkb": "Slc16a1; Mct1", "gene_names_refseq": "MCT1; RATMCT1; RNMCT1; Slc16a1", "protein_names_uniprotkb": "Monocarboxylate transporter 1; MCT 1; Solute carrier family 16 member 1", "protein_names_refseq": "MCT 1; monocarboxylate transporter 1; solute carrier 16 (monocarboxylic acid transporter), member 1; solute carrier family 16 (monocarboxylate transporter), member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)", "tax_id": 10116, "disease": "autosomal dominant disease (Disease Ontology:DOID:0050736); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); tonsil squamous cell carcinoma (Disease Ontology:DOID:0050920); scoliosis (Disease Ontology:DOID:0060249); Muenke Syndrome (Disease Ontology:DOID:0060703); familial hyperinsulinemic hypoglycemia 7 (Disease Ontology:DOID:0070214); bone disease (Disease Ontology:DOID:0080001); hypochondroplasia (Disease Ontology:DOID:0080041); lacrimoauriculodentodigital syndrome 2 (Disease Ontology:DOID:0081371); SADDAN (Disease Ontology:DOID:0111158); camptodactyly-tall stature-scoliosis-hearing loss syndrome (Disease Ontology:DOID:0111160); Crouzon syndrome-acanthosis nigricans syndrome (Disease Ontology:DOID:0111161); epidermal nevus (Disease Ontology:DOID:0111162); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); thanatophoric dysplasia (Disease Ontology:DOID:13481); breast cancer (Disease Ontology:DOID:1612); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); high grade glioma (Disease Ontology:DOID:3070); acanthosis nigricans (Disease Ontology:DOID:3138); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); chondrosarcoma (Disease Ontology:DOID:3371); breast adenocarcinoma (Disease Ontology:DOID:3458); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); Merkel cell carcinoma (Disease Ontology:DOID:3965); bladder urothelial carcinoma (Disease Ontology:DOID:4006); achondroplasia (Disease Ontology:DOID:4480); chronic myeloid leukemia (Disease Ontology:DOID:8552); tongue cancer (Disease Ontology:DOID:8649); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25027); (R-RNO-210991); (R-RNO-433692); (R-RNO-9749641)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10417314;10564700;11719518;16396499;17127621;19473976;21454685;22673903;31578706;33625690;34874512;38843836;38867145;7548134;8526936;9169423;9374487;9639576", "class_list": "", "function": "Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (PubMed:10417314, PubMed:10564700, PubMed:11719518, PubMed:17127621, PubMed:19473976, PubMed:8526936, PubMed:9374487, PubMed:9639576). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inhibition of Hypothalamic MCT4 and MCT1-MCT4 Expressions Affects Food Intake and Alters Orexigenic and Anorexigenic Neuropeptide Expressions., [RefSeq, PubMed]; Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats., [RefSeq, PubMed]; The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1alpha (HIF-1alpha), and PGC-1alpha gene expression in rat skeletal muscles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015295 solute:proton symporter activity;GO:0046943 carboxylic acid transmembrane transporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0045202 synapse", "go_biological_process": "GO:0035873 lactate transmembrane transport;GO:0006629 lipid metabolic process;GO:0032094 response to food;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P53987-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L108-1", "uniprot_id": [ { "id": "ARP5L_RAT", "url": "https://www.uniprot.org/uniprot/A1L108", "type": "external" } ], "mass": 17010.0, "length": 153, "protein_name": "Actin-related protein 2/3 complex subunit 5-like protein", "gene_name": "Arpc5l", "organism": "Rat", "refseq_name": "actin-related protein 2/3 complex subunit 5-like protein", "refseq_ac": [ { "id": "NP_001032856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032856", "type": "external" } ], "gene_names_uniprotkb": "Arpc5l", "gene_names_refseq": "Arpc5l1; Arpc5l", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 5-like protein; ARC16-2; Arp2/3 complex 16 kDa subunit 2", "protein_names_refseq": "ARC16-2; actin related protein 2/3 complex, subunit 5-like 1; actin-related protein 2/3 complex subunit 5-like protein; arp2/3 complex 16 kDa subunit 2", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:296710)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8889548", "class_list": "", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development., [UniProtKB, UniProtKB]; May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM42", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045202 synapse;GO:0030863 cortical cytoskeleton;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0016477 cell migration;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L108-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPQ1-1", "uniprot_id": [ { "id": "CG057_RAT", "url": "https://www.uniprot.org/uniprot/A0JPQ1", "type": "external" } ], "mass": 32757.0, "length": 292, "protein_name": "Uncharacterized protein C7orf57 homolog", "gene_name": "C14h7orf57", "organism": "Rat", "refseq_name": "uncharacterized protein C7orf57 homolog", "refseq_ac": [ { "id": "NP_001129387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129387", "type": "external" } ], "gene_names_uniprotkb": "C14h7orf57; LOC688553", "gene_names_refseq": "C14h7orf57; RGD1565273", "protein_names_uniprotkb": "Uncharacterized protein C7orf57 homolog", "protein_names_refseq": "uncharacterized protein C7orf57 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:688553)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQX4-1", "uniprot_id": [ { "id": "APC15_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQX4", "type": "external" } ], "mass": 15378.0, "length": 132, "protein_name": "Anaphase-promoting complex subunit 15", "gene_name": "Anapc15", "organism": "Rat", "refseq_name": "anaphase-promoting complex subunit 15", "refseq_ac": [ { "id": "NP_001163906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163906", "type": "external" } ], "gene_names_uniprotkb": "Anapc15", "gene_names_refseq": "APC15; Anapc15; RGD1311634", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 15; APC15", "protein_names_refseq": "anaphase-promoting complex subunit 15", "tax_id": 10116, "disease": "", "pathway": " (rno:293155); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Also required for degradation of CDC20 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4ACX3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2TGX5-1", "uniprot_id": [ { "id": "CLM8_RAT", "url": "https://www.uniprot.org/uniprot/A2TGX5", "type": "external" } ], "mass": 34495.0, "length": 310, "protein_name": "CMRF35-like molecule 8", "gene_name": "Cd300a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd300a", "gene_names_refseq": "", "protein_names_uniprotkb": "CMRF35-like molecule 8; CD300 antigen-like family member A; CLM-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:501736)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008429 phosphatidylethanolamine binding;GO:0001786 phosphatidylserine binding;GO:0019902 phosphatase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0014063 negative regulation of serotonin secretion;GO:0048147 negative regulation of fibroblast proliferation;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2TGX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35923-1", "uniprot_id": [ { "id": "BRCA2_RAT", "url": "https://www.uniprot.org/uniprot/O35923", "type": "external" } ], "mass": 372216.0, "length": 3343, "protein_name": "Breast cancer type 2 susceptibility protein homolog", "gene_name": "Brca2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Brca2; Fancd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Breast cancer type 2 susceptibility protein homolog; Fanconi anemia group D1 protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); ductal carcinoma in situ (Disease Ontology:DOID:0060074); multiple epiphyseal dysplasia 3 (Disease Ontology:DOID:0070304); Stickler syndrome (Disease Ontology:DOID:0080046); colorectal carcinoma (Disease Ontology:DOID:0080199); Fanconi anemia complementation group D1 (Disease Ontology:DOID:0111089); prostate cancer (Disease Ontology:DOID:10283); atrophy of testis (Disease Ontology:DOID:11994); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); nephroblastoma (Disease Ontology:DOID:2154); osteochondrodysplasia (Disease Ontology:DOID:2256); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); infertility (Disease Ontology:DOID:5223); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683); endometrial serous adenocarcinoma (Disease Ontology:DOID:5750); uveal melanoma (Disease Ontology:DOID:6039); cataract (Disease Ontology:DOID:83); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:360254); (R-RNO-5685939); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693568); (R-RNO-5693579); (R-RNO-5693616)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "12228710;9242436", "class_list": "", "function": "Tumor suppressor protein that maintains genome stability primarily by repairing damaged DNA through homologous recombination (HR). Facilitates the repair of double-strand breaks (DSBs) by binding and mediating the loading of the RAD51 protein onto single-stranded DNA (ssDNA), thereby promoting the activity of RAD51, which catalyzes DNA strand exchange. BRCA2 nucleates and stabilizes RAD51 on ssDNA directly and delivers RAD51 to ssDNA-double-stranded DNA (dsDNA) junctions by sliding along dsDNA backbone. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. Required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination. Also promotes RAD51 loading to telomeric regions, facilitating telomere replication and capping. Also required for homologous recombination during meiosis by promoting the recruitment of RAD51 and DMC1 recombinases to meiotic DSB sites, enabling proper chromosome pairing and crossing over. Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly. Together with NPM1, may also regulate centrosome duplication., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding;GO:0043015 gamma-tubulin binding;GO:0010484 histone H3 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030141 secretory granule", "go_biological_process": "GO:0031619 homologous chromosome orientation in meiotic metaphase I;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0007584 response to nutrient;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35923-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35796-1", "uniprot_id": [ { "id": "C1QBP_RAT", "url": "https://www.uniprot.org/uniprot/O35796", "type": "external" } ], "mass": 30997.0, "length": 279, "protein_name": "Complement component 1 Q subcomponent-binding protein, mitochondrial", "gene_name": "C1qbp", "organism": "Rat", "refseq_name": "complement component 1 Q subcomponent-binding protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_062132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062132", "type": "external" } ], "gene_names_uniprotkb": "C1qbp; Gc1qbp", "gene_names_refseq": "C1qbp; Habp1; gC1qR", "protein_names_uniprotkb": "Complement component 1 Q subcomponent-binding protein, mitochondrial; C1qBP; GC1q-R protein; Glycoprotein gC1qBP", "protein_names_refseq": "GC1q-R protein; complement component 1 Q subcomponent-binding protein, mitochondrial precursor; complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; glycoprotein gC1qBP", "tax_id": 10116, "disease": "autoimmune interstitial lung, joint, and kidney disease (Disease Ontology:DOID:0081242); combined oxidative phosphorylation deficiency 33 (Disease Ontology:DOID:0111495)", "pathway": " (rno:29681); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9855719); (R-RNO-9970672)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "24106277;25300617;28100784;34502162;38843836;9414106", "class_list": "", "function": "Data indicate that disrupted ovarian hyaluronan binding protein 1 (HABP1) along with concurrent altered expression and hyperactivation of related MMPs can lead to abnormal follicular maturation resulting into ovarian dysfunction in polycystic ovary (PCO)., [RefSeq, PubMed]; Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria (By similarity). In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. Acts as a RNA modification reader, which specifically recognizes and binds mitochondrial RNAs modified by C5-methylcytosine (m5C) in response to stress, and promotes recruitment of the mitochondrial degradosome complex, leading to their degradation (By similarity). May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles (By similarity). Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation (By similarity). Is required for the nuclear translocation of splicing factor U2AF1L4 (By similarity). Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. Acts as a regulator of DNA repair via homologous recombination by inhibiting the activity of MRE11: interacts with unphosphorylated MRE11 and RAD50 in absence of DNA damage, preventing formation and activity of the MRN complex. Following DNA damage, dissociates from phosphorylated MRE11, allowing formation of the MRN complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRS5", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0004857 enzyme inhibitor activity;GO:0003714 transcription corepressor activity;GO:0005080 protein kinase C binding;GO:0001849 complement component C1q complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D0Q0Y7-1", "uniprot_id": [ { "id": "CNIH3_RAT", "url": "https://www.uniprot.org/uniprot/D0Q0Y7", "type": "external" } ], "mass": 18962.0, "length": 160, "protein_name": "Protein cornichon homolog 3", "gene_name": "Cnih3", "organism": "Rat", "refseq_name": "protein cornichon homolog 3", "refseq_ac": [ { "id": "NP_001160050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160050", "type": "external" } ], "gene_names_uniprotkb": "Cnih3", "gene_names_refseq": "CNIH-3; Cnih3", "protein_names_uniprotkb": "Protein cornichon homolog 3; CNIH-3; Cornichon family AMPA receptor auxiliary protein 3", "protein_names_refseq": "cornichon 3; cornichon homolog 3; protein cornichon homolog 3", "tax_id": 10116, "disease": "", "pathway": " (rno:690252); (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19265014;25186755;31806817", "class_list": "", "function": "Findings show that the majority of AMPARs in the brain are coassembled with CNIH-2 & CNIH-3; cornichons increase surface expression of AMPARs, & alter channel gating by markedly slowing deactivation & desensitization kinetics, [RefSeq, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization., [UniProtKB, PubMed]; Reports high-resolution cryo-electron microscopy structures of AMPAR in complex with CNIH3. Contrary to its predicted membrane topology, CNIH3 lacks an extracellular domain and instead contains four membrane-spanning helices, [RefSeq, PubMed]; Residues in the membrane-proximal region of CNIHs that contribute to AMPAR binding and a segment in the CNIH-2/3 extracellular loop required for both physical interaction and gating modulation of the AMPAR, are identified., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043198 dendritic shaft;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0035249 synaptic transmission, glutamatergic;GO:0016192 vesicle-mediated transport;GO:2000311 regulation of AMPA receptor activity;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D0Q0Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TGK3-1", "uniprot_id": [ { "id": "ZDHC3_RAT", "url": "https://www.uniprot.org/uniprot/Q2TGK3", "type": "external" } ], "mass": 34113.0, "length": 299, "protein_name": "Palmitoyltransferase ZDHHC3", "gene_name": "Zdhhc3", "organism": "Rat", "refseq_name": "palmitoyltransferase ZDHHC3 isoform 2", "refseq_ac": [ { "id": "NP_001034103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034103", "type": "external" } ], "gene_names_uniprotkb": "Zdhhc3", "gene_names_refseq": "Zdhhc3", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC3; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC3; Zinc finger DHHC domain-containing protein 3", "protein_names_refseq": "acyltransferase ZDHHC3; palmitoyltransferase ZDHHC3 isoform 2; palmitoyltransferase ZDHHC3; zinc finger DHHC domain-containing protein 3; zinc finger DHHC-type palmitoyltransferase 3; zinc finger, DHHC domain containing 3; zinc finger, DHHC-type containing 3", "tax_id": 10116, "disease": "", "pathway": " (rno:301081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19596852;23687301", "class_list": "", "function": "Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (By similarity). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (By similarity). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (By similarity). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (PubMed:19596852). May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (By similarity). May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes (By similarity). Palmitoylates the Toll-like receptor 9/TLR9 in the Golgi and thereby regulates TLR9 trafficking to endosomes (By similarity). May palmitoylate CALHM1 and CALHM3 subunits of gustatory voltage-gated ion channels and modulate channel gating and kinetics (By similarity). Catalyzes the palmitoylation of CADM4 at 'Cys-347', ensuring its localization to the plasma membrane (PM) and protein stability (By similarity). The presence of CADM4 at the PM is essential for its function in CNS myelination, particularly through its associations with other cell adhesion molecules (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006605 protein targeting;GO:0006612 protein targeting to membrane;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0036462 TRAIL-activated apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2TGK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBZ4-1", "uniprot_id": [ { "id": "B1WBZ4_RAT", "url": "https://www.uniprot.org/uniprot/B1WBZ4", "type": "external" } ], "mass": 62091.0, "length": 537, "protein_name": "Cell division cycle 45", "gene_name": "Cdc45", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdc45", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell division cycle 45", "protein_names_refseq": "", "tax_id": 10116, "disease": "Meier-Gorlin syndrome 7 (Disease Ontology:DOID:0080518)", "pathway": " (rno:287961)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6JSE8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0036064 ciliary basal body;GO:0071162 CMG complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBZ4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70367-1", "uniprot_id": [ { "id": "CNMD_RAT", "url": "https://www.uniprot.org/uniprot/O70367", "type": "external" } ], "mass": 37387.0, "length": 334, "protein_name": "Leukocyte cell-derived chemotaxin 1", "gene_name": "Cnmd", "organism": "Rat", "refseq_name": "leukocyte cell-derived chemotaxin 1", "refseq_ac": [ { "id": "NP_110481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110481", "type": "external" } ], "gene_names_uniprotkb": "Cnmd; Chmi; Lect1", "gene_names_refseq": "Chm-1; Cnmd; Lect1", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin 1; ChM-I; Chondromodulin-I; Chondromodulin", "protein_names_refseq": "chM-I; chondromodulin-1; chondromodulin-I; leukocyte cell derived chemotaxin 1; leukocyte cell-derived chemotaxin 1", "tax_id": 10116, "disease": "", "pathway": " (rno:81512)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11328727;14527163;15200412;16980969;18337200;24710035;28263889", "class_list": "", "function": "Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Chm-1 expression was studied in articular cartilage and compared with that in the growth plate., [RefSeq, PubMed]; Data show that chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mandibular condylar and other growth cartilages., [RefSeq, PubMed]; In experimental uremia, expansion of growth cartilage does not result from increased or persistent expression of ChM-I or from reduced VEGF expression at the cartilage-metaphyseal bone interphase., [RefSeq, PubMed]; Intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage Publication Status: Online-Only, [RefSeq, PubMed]; These results demonstrate novel information about the molecular mechanism by which ChM-I induce MSCs to differentiate into chondrocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0051216 cartilage development;GO:0001886 endothelial cell morphogenesis;GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M8B7-1", "uniprot_id": [ { "id": "F1M8B7_RAT", "url": "https://www.uniprot.org/uniprot/F1M8B7", "type": "external" } ], "mass": 23935.0, "length": 213, "protein_name": "Charged multivesicular body protein 2B", "gene_name": "Chmp2b", "organism": "Rat", "refseq_name": "charged multivesicular body protein 2b", "refseq_ac": [ { "id": "NP_001385742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385742", "type": "external" } ], "gene_names_uniprotkb": "Chmp2b", "gene_names_refseq": "Chmp2b; RGD1306781", "protein_names_uniprotkb": "Charged multivesicular body protein 2B", "protein_names_refseq": "charged multivesicular body protein 2b; chromatin modifying protein 2B", "tax_id": 10116, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7 (Disease Ontology:DOID:0111227); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:363720); (R-RNO-1632852); (R-RNO-5620971); (R-RNO-917729); (R-RNO-9668328)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;36907288", "class_list": "", "function": "Charged multivesicular body protein 2B ameliorates biliary injury in the liver from donation after cardiac death rats via autophagy with air-oxygenated normothermic machine perfusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005643 nuclear pore", "go_biological_process": "GO:0007034 vacuolar transport;GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1M8B7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8X2-1", "uniprot_id": [ { "id": "G3V8X2_RAT", "url": "https://www.uniprot.org/uniprot/G3V8X2", "type": "external" } ], "mass": 26082.0, "length": 228, "protein_name": "Derlin", "gene_name": "Derl3", "organism": "Rat", "refseq_name": "derlin-3", "refseq_ac": [ { "id": "NP_001103047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103047", "type": "external" } ], "gene_names_uniprotkb": "Derl3", "gene_names_refseq": "Derl3", "protein_names_uniprotkb": "Derlin", "protein_names_refseq": "Der1-like domain family, member 3; derlin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:690315); (R-RNO-382556); (R-RNO-9931269)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19940266", "class_list": "", "function": "Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB, UniProtKB]; Study describes a potentially protective role for Derl3 in the heart., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005047 signal recognition particle binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:1904153 negative regulation of retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1H7-1", "uniprot_id": [ { "id": "D4A1H7_RAT", "url": "https://www.uniprot.org/uniprot/D4A1H7", "type": "external" } ], "mass": 39781.0, "length": 352, "protein_name": "Mitochondrial ubiquitin ligase activator of NFKB 1", "gene_name": "Mul1", "organism": "Rat", "refseq_name": "mitochondrial ubiquitin ligase activator of NFKB 1", "refseq_ac": [ { "id": "NP_001100165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100165", "type": "external" } ], "gene_names_uniprotkb": "Mul1", "gene_names_refseq": "Mul1; RGD1309944", "protein_names_uniprotkb": "Mitochondrial ubiquitin ligase activator of NFKB 1; 2.3.2.27; E3 ubiquitin-protein ligase MUL1; Protein Hades; RING-type E3 ubiquitin transferase NFKB 1", "protein_names_refseq": "mitochondrial ubiquitin ligase activator of NFKB 1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:298576); (R-RNO-5689880); (R-RNO-8951664); (R-RNO-9755511)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "26203915;28782654;31430457;31825666", "class_list": "", "function": "Cigarette smoke-induced MUL1 elevation mediates Akt ubiquitination/degradation, potentially leading to pulmonary endothelial cell death and functional impairment., [RefSeq, PubMed]; This study exhibits a novel signaling axis composed of miR-485-5p/MAPL/Mfn2, which regulates mitochondrial machinery and cardiac hypertrophy., [RefSeq, PubMed]; Upregulation of Mul1 contributes to brain injury in ischemic stroke rats and disturbs mitochondrial dynamics through sumoylation of Drp1 and ubiquitination of Mfn2, [RefSeq, PubMed]; Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:1903861 positive regulation of dendrite extension;GO:0050689 negative regulation of defense response to virus by host;GO:0051881 regulation of mitochondrial membrane potential;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A1H7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZYN8-1", "uniprot_id": [ { "id": "Q6ZYN8_RAT", "url": "https://www.uniprot.org/uniprot/Q6ZYN8", "type": "external" } ], "mass": 41899.0, "length": 373, "protein_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase", "gene_name": "St6galnac2", "organism": "Rat", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2", "refseq_ac": [ { "id": "NP_001026822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026822", "type": "external" } ], "gene_names_uniprotkb": "St6galnac2", "gene_names_refseq": "Siat7b; St6galnac2", "protein_names_uniprotkb": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase; 2.4.3.3", "protein_names_refseq": "Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6 GalNAc alpha-2,6-sialyltransferase 2; ST6GALNAC2, alpha-2,6-sialyltransferase 2; ST6GalNAc II; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II (); sialyltransferase 7B", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:303692); (R-RNO-4085001); (R-RNO-977068)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HKY6", "ec_number_list": [ { "id": "2.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.3", "type": "external" }, { "id": "2.4.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.7", "type": "external" } ], "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:1990743 protein sialylation", "synthesized_glycan_count": 550, "hit_score": 0.1, "record_id": "Q6ZYN8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6M1-1", "uniprot_id": [ { "id": "A0A0G2K6M1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M1", "type": "external" } ], "mass": 40911.0, "length": 372, "protein_name": "Protein boule-like", "gene_name": "Boll", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Boll; LOC100911373", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein boule-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008494 translation activator activity;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0051321 meiotic cell cycle;GO:0045948 positive regulation of translational initiation;GO:0070935 3'-UTR-mediated mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K6M1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNS8-1", "uniprot_id": [ { "id": "D3ZNS8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNS8", "type": "external" } ], "mass": 59361.0, "length": 546, "protein_name": "Aladin", "gene_name": "Aaas", "organism": "Rat", "refseq_name": "aladin isoform 1", "refseq_ac": [ { "id": "NP_001100265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100265", "type": "external" } ], "gene_names_uniprotkb": "Aaas", "gene_names_refseq": "Aaas", "protein_names_uniprotkb": "Aladin; Adracalin", "protein_names_refseq": "achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A); aladin isoform 1", "tax_id": 10116, "disease": "triple-A syndrome (Disease Ontology:DOID:0050602); achalasia (Disease Ontology:DOID:9164)", "pathway": " (rno:300259); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-8980692)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005643 nuclear pore;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0006913 nucleocytoplasmic transport;GO:0006979 response to oxidative stress;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZNS8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M3Z8-1", "uniprot_id": [ { "id": "F1M3Z8_RAT", "url": "https://www.uniprot.org/uniprot/F1M3Z8", "type": "external" } ], "mass": 76754.0, "length": 665, "protein_name": "Zinc finger protein 873", "gene_name": "Zfp873", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp873; LOC100912294", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 873", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100912294)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M3Z8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M9C9-1", "uniprot_id": [ { "id": "F1M9C9_RAT", "url": "https://www.uniprot.org/uniprot/F1M9C9", "type": "external" } ], "mass": 57328.0, "length": 507, "protein_name": "histidine--tRNA ligase", "gene_name": "Hars2; Zmat2", "organism": "Rat", "refseq_name": "probable histidine--tRNA ligase, mitochondrial", "refseq_ac": [ { "id": "NP_001014034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014034", "type": "external" } ], "gene_names_uniprotkb": "Hars2; Zmat2; Hars2; Zmat2", "gene_names_refseq": "Hars2l; Hars2; RGD1308426; Zmat2", "protein_names_uniprotkb": "histidine--tRNA ligase; 6.1.1.21; Histidyl-tRNA synthetase", "protein_names_refseq": "histidyl-tRNA synthetase 2, mitochondrial (putative); probable histidine--tRNA ligase, mitochondrial; zinc finger, matrin type 2", "tax_id": 10116, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Perrault syndrome 2 (Disease Ontology:DOID:0061117); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (rno:307491); (rno:679898)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071005 U2-type precatalytic spliceosome;GO:0005739 mitochondrion", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M9C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAB8-1", "uniprot_id": [ { "id": "F1MAB8_RAT", "url": "https://www.uniprot.org/uniprot/F1MAB8", "type": "external" } ], "mass": 118295.0, "length": 1056, "protein_name": "Kinesin-like protein KIF11", "gene_name": "Kif11", "organism": "Rat", "refseq_name": "kinesin-like protein KIF11", "refseq_ac": [ { "id": "NP_001162583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162583", "type": "external" } ], "gene_names_uniprotkb": "Kif11", "gene_names_refseq": "Kif11; Knsl1", "protein_names_uniprotkb": "Kinesin-like protein KIF11; Kinesin-related motor protein Eg5", "protein_names_refseq": "kinesin-like 1; kinesin-like protein KIF11", "tax_id": 10116, "disease": "microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (Disease Ontology:DOID:0060349)", "pathway": " (rno:171304); (R-RNO-2132295); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16418225;19084405;22698524;29393594", "class_list": "", "function": "Corticotropin releasing hormone act on CRHR1 to induce MKLP1 expression via the PLC/PKC signaling pathway., [RefSeq, PubMed]; Kinesin-5 works in part by antagonizing cytoplasmic dynein, and these motor-driven forces function together with the dynamic properties of the microtubules to determine whether MTs can enter the P-domain., [RefSeq, PubMed]; The motor and tail regions of MKLP1 are important and significant for its localization to the dendrites, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008574 plus-end-directed microtubule motor activity;GO:0003777 microtubule motor activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005876 spindle microtubule;GO:0072686 mitotic spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0051231 spindle elongation;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MAB8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R5W6-1", "uniprot_id": [ { "id": "M0R5W6_RAT", "url": "https://www.uniprot.org/uniprot/M0R5W6", "type": "external" } ], "mass": 12324.0, "length": 114, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000069088", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000069088", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R5W6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M7N7-1", "uniprot_id": [ { "id": "F1M7N7_RAT", "url": "https://www.uniprot.org/uniprot/F1M7N7", "type": "external" } ], "mass": 83169.0, "length": 733, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "Rps6ka2", "organism": "Rat", "refseq_name": "ribosomal protein S6 kinase alpha-2", "refseq_ac": [ { "id": "NP_476469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476469", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka2", "gene_names_refseq": "Rps6ka2", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2", "tax_id": 10116, "disease": "Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (rno:117269); (R-RNO-198753); (R-RNO-199920); (R-RNO-2559582); (R-RNO-442742); (R-RNO-444257); (R-RNO-881907)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "12080086;19418583;21891976;22997248", "class_list": "", "function": "Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy., [RefSeq, PubMed]; Data show that p90RSK is over-expressed in activated hepatic stellate cells (HSCs) and is involved in regulating the abnormal expression of collagen type I through initiating the proliferation of HSCs., [RefSeq, PubMed]; Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E, [RefSeq, PubMed]; These findings suggest that nicotinamide protects neuronal cells against cerebral ischemic injury and that MEK-ERK-p90RSK cascade activation by nicotinamide contributes to these neuroprotective effects., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0072687 meiotic spindle;GO:0005634 nucleus;GO:0005819 spindle", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0045786 negative regulation of cell cycle;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1M7N7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9J8-1", "uniprot_id": [ { "id": "D4A9J8_RAT", "url": "https://www.uniprot.org/uniprot/D4A9J8", "type": "external" } ], "mass": 82745.0, "length": 750, "protein_name": "Kelch-like family member 1", "gene_name": "Klhl1", "organism": "Rat", "refseq_name": "kelch-like protein 1", "refseq_ac": [ { "id": "NP_001381602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381602", "type": "external" } ], "gene_names_uniprotkb": "Klhl1", "gene_names_refseq": "Klhl1", "protein_names_uniprotkb": "Kelch-like family member 1", "protein_names_refseq": "kelch-like 1; kelch-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290426)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16982692;17324934", "class_list": "", "function": "MRP2/KLHL1 has a role, through its interaction with actin, in the process elongation of oligodendrocytes, [RefSeq, PubMed]; This study provides, for the first time, insights into the involvement of MRP2 in neurite outgrowth, which occurs in a GSK3beta-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0016358 dendrite development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007626 locomotory behavior;GO:0007628 adult walking behavior;GO:0021680 cerebellar Purkinje cell layer development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A9J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LM37-1", "uniprot_id": [ { "id": "F1LM37_RAT", "url": "https://www.uniprot.org/uniprot/F1LM37", "type": "external" } ], "mass": 68939.0, "length": 641, "protein_name": "Splicing factor 1", "gene_name": "Sf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Splicing factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "ischemia (Disease Ontology:DOID:326)", "pathway": " (rno:117855)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;34502162", "class_list": "", "function": "Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "I6L9G4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0045131 pre-mRNA branch point binding;GO:0042802 identical protein binding;GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0016604 nuclear body;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0080090 regulation of primary metabolic process;GO:0006351 DNA-templated transcription;GO:0048662 negative regulation of smooth muscle cell proliferation;GO:0033327 Leydig cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1LM37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35547-1", "uniprot_id": [ { "id": "ACSL4_RAT", "url": "https://www.uniprot.org/uniprot/O35547", "type": "external" } ], "mass": 79065.0, "length": 711, "protein_name": "Long-chain-fatty-acid--CoA ligase 4", "gene_name": "Acsl4", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase 4 isoform 2", "refseq_ac": [ { "id": "NP_446075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446075", "type": "external" } ], "gene_names_uniprotkb": "Acsl4; Acs4; Facl4", "gene_names_refseq": "Acs4; Acsl4; Facl4", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 4; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 4; Long-chain acyl-CoA synthetase 4", "protein_names_refseq": "LACS 4; arachidonate--CoA ligase; fatty acid-Coenzyme A ligase, long chain 4; long-chain acyl-CoA synthetase 4; long-chain-fatty-acid--CoA ligase 4 isoform 2; long-chain-fatty-acid--CoA ligase 4", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); intellectual disability (Disease Ontology:DOID:1059); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (rno:113976); (R-RNO-434313); (R-RNO-75876)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15683247;23766516;28209804;33246155;33314758;37541340;38462207;38734267;38843836;9096315", "class_list": "", "function": "ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage., [RefSeq, PubMed]; Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis., [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:23766516, PubMed:28209804, PubMed:9096315). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:9096315). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET (PubMed:23766516). Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (PubMed:23766516). Modulates prostaglandin E2 secretion (By similarity). Acts as an activator of ferroptosis by activating polyunsaturated fatty acids, especially arachidonate and adrenate, to their active form, generating the primary lipid-peroxidation substrates that contribute to ferroptosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m[6]A modification., [RefSeq, PubMed]; Regulation and role of Acyl-CoA synthetase 4 in glial cells., [RefSeq, PubMed]; YAP Facilitates NEDD4L-Mediated Ubiquitination and Degradation of ACSL4 to Alleviate Ferroptosis in Myocardial Ischemia-Reperfusion Injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35547-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V799-1", "uniprot_id": [ { "id": "G3V799_RAT", "url": "https://www.uniprot.org/uniprot/G3V799", "type": "external" } ], "mass": 49277.0, "length": 441, "protein_name": "G protein-coupled receptor 180", "gene_name": "Gpr180", "organism": "Rat", "refseq_name": "integral membrane protein GPR180 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001401931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401931", "type": "external" } ], "gene_names_uniprotkb": "Gpr180", "gene_names_refseq": "Gpr180", "protein_names_uniprotkb": "G protein-coupled receptor 180", "protein_names_refseq": "integral membrane protein GPR180 isoform 2 precursor; integral membrane protein GPR180; intimal thickness-related receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:306165)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIJ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0019236 response to pheromone;GO:0006091 generation of precursor metabolites and energy;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V799-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHK1-1", "uniprot_id": [ { "id": "Q9JHK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHK1", "type": "external" } ], "mass": 50400.0, "length": 454, "protein_name": "Caspase-9", "gene_name": "Casp9", "organism": "Rat", "refseq_name": "caspase-9 isoform 1", "refseq_ac": [ { "id": "NP_113820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113820", "type": "external" } ], "gene_names_uniprotkb": "Casp9; Casp9_v1", "gene_names_refseq": "Apaf3; Casp-9-CTD; Casp9_v1; Casp9; Ice-Lap6; Mch6", "protein_names_uniprotkb": "Caspase-9; 3.4.22.62; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6", "protein_names_refseq": "25 kDa caspase-9 dominant negative protein; Ice-like apoptotic protease 6; apoptotic protease Mch-6; apoptotic protease activating factor 3; caspase 9, apoptosis-related cysteine peptidase; caspase-9 dominant negative form; caspase-9 isoform 1; caspase-9-carboxyl-terminal divergent", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); endometritis (Disease Ontology:DOID:1002); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); varicocele (Disease Ontology:DOID:12337); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); severe acute respiratory syndrome (Disease Ontology:DOID:2945); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:58918); (R-RNO-111458); (R-RNO-111459); (R-RNO-168638); (R-RNO-198323); (R-RNO-418889); (R-RNO-9627069)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "11431480;22673903;33224431;33847039;34304702;34314869", "class_list": "", "function": "Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models., [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC., [UniProtKB, UniProtKB]; Oxidative Stress Induces Chondrocyte Apoptosis through Caspase-Dependent and Caspase-Independent Mitochondrial Pathways and the Antioxidant Mechanism of Angelica Sinensis Polysaccharide. Publication Status: Online-Only, [RefSeq, PubMed]; PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway., [RefSeq, PubMed]; Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction., [RefSeq, PubMed]; The activation of caspase-8, but not caspase-9, is necessary for Fas-induced apoptosis. Conversely, caspase-9, but not caspase-8, is important for UV-mediated shrunken morphology and apoptosis progression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1M776", "ec_number_list": [ { "id": "4.2.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.109", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0070513 death domain binding;GO:0002020 protease binding;GO:0004197 cysteine-type endopeptidase activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043293 apoptosome", "go_biological_process": "GO:0006508 proteolysis;GO:0042981 regulation of apoptotic process;GO:0071680 response to indole-3-methanol;GO:0002931 response to ischemia;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498E3-1", "uniprot_id": [ { "id": "Q498E3_RAT", "url": "https://www.uniprot.org/uniprot/Q498E3", "type": "external" } ], "mass": 26204.0, "length": 237, "protein_name": "Similar to human chromosome 13 open reading frame 46", "gene_name": "C16h13orf46", "organism": "Rat", "refseq_name": "uncharacterized protein C13orf46 homolog", "refseq_ac": [ { "id": "NP_001032259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032259", "type": "external" } ], "gene_names_uniprotkb": "C16h13orf46; LOC290876", "gene_names_refseq": "C16h13orf46", "protein_names_uniprotkb": "Similar to human chromosome 13 open reading frame 46", "protein_names_refseq": "uncharacterized protein C13orf46 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290876)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498E3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F3I7-1", "uniprot_id": [ { "id": "F7F3I7_RAT", "url": "https://www.uniprot.org/uniprot/F7F3I7", "type": "external" } ], "mass": 83519.0, "length": 762, "protein_name": "Semaphorin-4A", "gene_name": "Sema4a", "organism": "Rat", "refseq_name": "semaphorin-4A precursor", "refseq_ac": [ { "id": "NP_001012078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012078", "type": "external" } ], "gene_names_uniprotkb": "Sema4a", "gene_names_refseq": "Sema4a", "protein_names_uniprotkb": "Semaphorin-4A; Semaphorin-B", "protein_names_refseq": "sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; semaphorin-4A precursor", "tax_id": 10116, "disease": "retinitis pigmentosa 35 (Disease Ontology:DOID:0110357); cone-rod dystrophy 10 (Disease Ontology:DOID:0111017)", "pathway": " (rno:310630); (R-RNO-416700)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0120035 regulation of plasma membrane bounded cell projection organization;GO:0002292 T cell differentiation involved in immune response;GO:0045063 T-helper 1 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F7F3I7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PTB4-1", "uniprot_id": [ { "id": "E9PTB4_RAT", "url": "https://www.uniprot.org/uniprot/E9PTB4", "type": "external" } ], "mass": 26514.0, "length": 238, "protein_name": "Secreted and transmembrane 1B", "gene_name": "Sectm1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sectm1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Secreted and transmembrane 1B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287884)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0002726 positive regulation of T cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PTB4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU38-1", "uniprot_id": [ { "id": "E9PU38_RAT", "url": "https://www.uniprot.org/uniprot/E9PU38", "type": "external" } ], "mass": 20863.0, "length": 202, "protein_name": "Acidic proline-rich protein 25-like 1", "gene_name": "AABR07062238.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07062238.1; Prp25l1; RGD1559532", "gene_names_refseq": "", "protein_names_uniprotkb": "Acidic proline-rich protein 25-like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E9PU38-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LLW8-1", "uniprot_id": [ { "id": "F1LLW8_RAT", "url": "https://www.uniprot.org/uniprot/F1LLW8", "type": "external" } ], "mass": 62556.0, "length": 554, "protein_name": "Iduronate 2-sulfatase", "gene_name": "Ids", "organism": "Rat", "refseq_name": "iduronate 2-sulfatase precursor", "refseq_ac": [ { "id": "NP_001388114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388114", "type": "external" } ], "gene_names_uniprotkb": "Ids", "gene_names_refseq": "Ids", "protein_names_uniprotkb": "Iduronate 2-sulfatase; 3.1.6.13; Alpha-L-iduronate sulfate sulfatase", "protein_names_refseq": "iduronate 2-sulfatase precursor", "tax_id": 10116, "disease": "mucopolysaccharidosis II (Disease Ontology:DOID:12799)", "pathway": " (rno:363513); (R-RNO-2024096); (R-RNO-2024101)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.13", "type": "external" } ], "go_molecular_function": "GO:0004423 iduronate-2-sulfatase activity;GO:0005509 calcium ion binding;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0006027 glycosaminoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LLW8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LNH0-1", "uniprot_id": [ { "id": "F1LNH0_RAT", "url": "https://www.uniprot.org/uniprot/F1LNH0", "type": "external" } ], "mass": 86852.0, "length": 780, "protein_name": "Semaphorin 3G", "gene_name": "Sema3g", "organism": "Rat", "refseq_name": "semaphorin-3G precursor", "refseq_ac": [ { "id": "NP_001094352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094352", "type": "external" } ], "gene_names_uniprotkb": "Sema3g", "gene_names_refseq": "CSG53; RGD1306079; Sema3g", "protein_names_uniprotkb": "Semaphorin 3G", "protein_names_refseq": "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G; semaphorin-3G precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:290562)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LNH0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LP42-1", "uniprot_id": [ { "id": "F1LP42_RAT", "url": "https://www.uniprot.org/uniprot/F1LP42", "type": "external" } ], "mass": 45473.0, "length": 411, "protein_name": "Hedgehog protein", "gene_name": "Ihh", "organism": "Rat", "refseq_name": "indian hedgehog protein precursor", "refseq_ac": [ { "id": "NP_445836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445836", "type": "external" } ], "gene_names_uniprotkb": "Ihh", "gene_names_refseq": "Ihh", "protein_names_uniprotkb": "Hedgehog protein", "protein_names_refseq": "indian hedgehog protein precursor", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); familial adenomatous polyposis (Disease Ontology:DOID:0050424); acrocapitofemoral dysplasia (Disease Ontology:DOID:0050604); autism spectrum disorder (Disease Ontology:DOID:0060041); annular pancreas (Disease Ontology:DOID:0060850); brachydactyly type A1 (Disease Ontology:DOID:0110964); syndactyly type 1 (Disease Ontology:DOID:0111816); Hirschsprung's disease (Disease Ontology:DOID:10487); retinopathy of prematurity (Disease Ontology:DOID:13025); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:84399); (R-RNO-5358346); (R-RNO-5362798); (R-RNO-5632681)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "31302828;33637095;33850470;38607081", "class_list": "", "function": "ERbeta Regulation of Indian Hedgehog Expression in the First Wave of Ovarian Follicles. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-143 is implicated in growth plate injury by targeting IHH in precartilaginous stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product., [UniProtKB, UniProtKB]; The Ihh signaling pathway may activate the occurrence of Temporomandibular joint osteoarthritis by mediating the hypertrophy of chondrocytes, [RefSeq, PubMed]; The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development., [UniProtKB, UniProtKB]; The value of the hedgehog signal in osteoblasts in fluoride-induced bone-tissue injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0016740 transferase activity;GO:0008233 peptidase activity;GO:0005113 patched binding;GO:0034189 very-low-density lipoprotein particle binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060323 head morphogenesis;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0046639 negative regulation of alpha-beta T cell differentiation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1LP42-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LPV0-1", "uniprot_id": [ { "id": "F1LPV0_RAT", "url": "https://www.uniprot.org/uniprot/F1LPV0", "type": "external" } ], "mass": 64199.0, "length": 559, "protein_name": "Asparagine--tRNA ligase, cytoplasmic", "gene_name": "Nars1", "organism": "Rat", "refseq_name": "asparagine--tRNA ligase, cytoplasmic isoform 3", "refseq_ac": [ { "id": "NP_001385496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385496", "type": "external" } ], "gene_names_uniprotkb": "Nars1; Nars", "gene_names_refseq": "LRRGT00113; Nars1; Nars", "protein_names_uniprotkb": "Asparagine--tRNA ligase, cytoplasmic; 6.1.1.22; Asparaginyl-tRNA synthetase 1; Asparaginyl-tRNA synthetase", "protein_names_refseq": "asparagine--tRNA ligase, cytoplasmic isoform 3; asparagine--tRNA ligase, cytoplasmic; asparaginyl-tRNA synthetase, cytoplasmic", "tax_id": 10116, "disease": "autosomal dominant distal hereditary motor neuronopathy (Disease Ontology:DOID:0111198); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (rno:291556)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046983 protein dimerization activity;GO:0003676 nucleic acid binding;GO:0031728 CCR3 chemokine receptor binding;GO:0004816 asparagine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016477 cell migration;GO:0021987 cerebral cortex development;GO:0006421 asparaginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1LPV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, 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Or10a4; ratchr1-164484422-164485369_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 231; olfactory receptor Olr231; olfactory receptor gene Olr231", "tax_id": 10116, "disease": "", "pathway": " (rno:293375)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007411 axon guidance;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M571-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M590-1", "uniprot_id": [ { "id": "F1M590_RAT", "url": "https://www.uniprot.org/uniprot/F1M590", "type": "external" } ], "mass": 59290.0, "length": 543, "protein_name": "Hdc homolog, cell cycle regulator", "gene_name": "Heca", "organism": "Rat", "refseq_name": "headcase protein homolog", "refseq_ac": [ { "id": "NP_001100984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100984", "type": "external" } ], "gene_names_uniprotkb": "Heca", "gene_names_refseq": "Heca", "protein_names_uniprotkb": "Hdc homolog, cell cycle regulator", "protein_names_refseq": "hdc homolog, cell cycle regulator; headcase homolog; headcase protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:308624)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045930 negative regulation of mitotic cell cycle;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M590-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M5Q4-1", "uniprot_id": [ { "id": "F1M5Q4_RAT", "url": "https://www.uniprot.org/uniprot/F1M5Q4", "type": "external" } ], "mass": 313609.0, "length": 2907, "protein_name": "Fibrillin-2", "gene_name": "Fbn2", "organism": "Rat", "refseq_name": "fibrillin-2 precursor", "refseq_ac": [ { "id": "NP_114014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114014", "type": "external" } ], "gene_names_uniprotkb": "Fbn2", "gene_names_refseq": "Fbn2", "protein_names_uniprotkb": "Fibrillin-2", "protein_names_refseq": "fibrillin-2 precursor; fibrillin-2-like", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); scoliosis (Disease Ontology:DOID:0060249); congenital contractural arachnodactyly (Disease Ontology:DOID:0111595); Marfan syndrome (Disease Ontology:DOID:14323)", "pathway": " (rno:689008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0001527 microfibril", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0001890 placenta development;GO:0030326 embryonic limb morphogenesis;GO:0048048 embryonic eye morphogenesis;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M5Q4-1", "record_type": "protein", "filter_code": "0000000.0000011.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M6D0-1", "uniprot_id": [ { "id": "F1M6D0_RAT", "url": "https://www.uniprot.org/uniprot/F1M6D0", "type": "external" } ], "mass": 19487.0, "length": 169, "protein_name": "Small ribosomal subunit protein bS6m", "gene_name": "Mrps6", "organism": "Rat", "refseq_name": "mitochondrial ribosomal protein S6 isoform 2", "refseq_ac": [ { "id": "NP_001424225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424225", "type": "external" } ], "gene_names_uniprotkb": "Mrps6", "gene_names_refseq": "Mrps6", "protein_names_uniprotkb": "Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial", "protein_names_refseq": "28S ribosomal protein S6, mitochondrial; mitochondrial ribosomal protein S6 isoform 2; small ribosomal subunit protein bS6m", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M6D0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M6T7-1", "uniprot_id": [ { "id": "F1M6T7_RAT", "url": "https://www.uniprot.org/uniprot/F1M6T7", "type": "external" } ], "mass": 40980.0, "length": 380, "protein_name": "Glutamate-rich 5", "gene_name": "Erich5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Erich5; LOC681820", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate-rich 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:681820)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M6T7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M7Z1-1", "uniprot_id": [ { "id": "F1M7Z1_RAT", "url": "https://www.uniprot.org/uniprot/F1M7Z1", "type": "external" } ], "mass": 56093.0, "length": 508, "protein_name": "Enhancer of mRNA-decapping protein 3", "gene_name": "Edc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Edc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Enhancer of mRNA-decapping protein 3; YjeF domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 50 (Disease Ontology:DOID:0081213)", "pathway": " (R-RNO-430039)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0033962 P-body assembly;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M7Z1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M8B2-1", "uniprot_id": [ 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"reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008251 tRNA-specific adenosine deaminase activity;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0007286 spermatid development;GO:0006382 adenosine to inosine editing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M8B2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M8J6-1", "uniprot_id": [ { "id": "F1M8J6_RAT", "url": "https://www.uniprot.org/uniprot/F1M8J6", "type": "external" } ], "mass": 84973.0, "length": 780, "protein_name": "ADAM metallopeptidase domain 33", "gene_name": "Adam33", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 33 precursor", "refseq_ac": [ { "id": "NP_001382042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382042", "type": "external" } ], "gene_names_uniprotkb": "Adam33", "gene_names_refseq": "Adam33", "protein_names_uniprotkb": "ADAM metallopeptidase domain 33", "protein_names_refseq": "a disintegrin and metallopeptidase domain 33; a disintegrin and metalloprotease domain 33; disintegrin and metalloproteinase domain-containing protein 33 precursor; disintegrin and metalloproteinase domain-containing protein 33", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "23934418;27720670", "class_list": "", "function": "ADAM33 is a mediator of airway smooth muscle cell dysfunction in asthma., [RefSeq, PubMed]; Soluble ADAM33 overexpression altered the mechanical behaviors of airway smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1M8J6-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M928-1", "uniprot_id": [ { "id": "JUNO_RAT", "url": "https://www.uniprot.org/uniprot/F1M928", "type": "external" } ], "mass": 28026.0, "length": 244, "protein_name": "Sperm-egg fusion protein Juno", "gene_name": "Izumo1r", "organism": "Rat", "refseq_name": "sperm-egg fusion protein Juno precursor", "refseq_ac": [ { "id": "NP_001385730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385730", "type": "external" } ], "gene_names_uniprotkb": "Izumo1r; Folr4; JUNO", "gene_names_refseq": "Folr4; Izumo1r; JUNO", "protein_names_uniprotkb": "Sperm-egg fusion protein Juno; FR-delta; Folate receptor 4; Folate receptor delta; IZUMO1 receptor protein JUNO", "protein_names_refseq": "FR-delta; IZUMO1 receptor protein JUNO; folate receptor 4 (delta); probable folate receptor delta; sperm-egg fusion protein Juno precursor; sperm-egg fusion protein Juno", "tax_id": 10116, "disease": "", "pathway": " (rno:690037); (R-RNO-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37951137", "class_list": "", "function": "Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO., [RefSeq, PubMed]; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B1W5N3;A6JNA9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M928-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MA87-1", "uniprot_id": [ { "id": "F1MA87_RAT", "url": "https://www.uniprot.org/uniprot/F1MA87", "type": "external" } ], "mass": 36952.0, "length": 326, "protein_name": "cyclin-dependent kinase", "gene_name": "Cdk6", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 6", "refseq_ac": [ { "id": "NP_001178790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178790", "type": "external" } ], "gene_names_uniprotkb": "Cdk6", "gene_names_refseq": "Cdk6", "protein_names_uniprotkb": "cyclin-dependent kinase; 2.7.11.22", "protein_names_refseq": "cell division protein kinase 6; cyclin-dependent kinase 6", "tax_id": 10116, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); primary autosomal recessive microcephaly 12 (Disease Ontology:DOID:0070284); intellectual disability (Disease Ontology:DOID:1059); cystinosis (Disease Ontology:DOID:1064); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); non-functioning pancreatic endocrine tumor (Disease Ontology:DOID:7698); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (rno:114483); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-69231); (R-RNO-8934593); (R-RNO-9754119)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "22673903;26707878;30701428", "class_list": "", "function": "A small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being developed., [RefSeq, PubMed]; Taken together, these data suggested that both Nanog may play important roles in spinal cord pathophysiology via interact with CDK6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0098770 FBXO family protein binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1MA87-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAF2-1", "uniprot_id": [ { "id": "F1MAF2_RAT", "url": "https://www.uniprot.org/uniprot/F1MAF2", "type": "external" } ], "mass": 77554.0, "length": 712, "protein_name": "A-kinase anchoring protein 17A", "gene_name": "Akap17a", "organism": "Rat", "refseq_name": "A-kinase anchor protein 17A", "refseq_ac": [ { "id": "NP_001120718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120718", "type": "external" } ], "gene_names_uniprotkb": "Akap17a", "gene_names_refseq": "Akap17a", "protein_names_uniprotkb": "A-kinase anchoring protein 17A", "protein_names_refseq": "A kinase (PRKA) anchor protein 17A; A-kinase anchor protein 17A", "tax_id": 10116, "disease": "", "pathway": " (rno:288526)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MAF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAM9-1", "uniprot_id": [ { "id": "F1MAM9_RAT", "url": "https://www.uniprot.org/uniprot/F1MAM9", "type": "external" } ], "mass": 84280.0, "length": 783, "protein_name": "Transcription factor E4F1", "gene_name": "E4f1", "organism": "Rat", "refseq_name": "transcription factor E4F1", "refseq_ac": [ { "id": "NP_001171975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171975", "type": "external" } ], "gene_names_uniprotkb": "E4f1", "gene_names_refseq": "Dnase1l2; E4f1", "protein_names_uniprotkb": "Transcription factor E4F1; 2.3.2.27; E4F transcription factor 1; Putative E3 ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin transferase E4F1; Transcription factor E4F; p120E4F", "protein_names_refseq": "deoxyribonuclease 1-like 2; transcription factor E4F1", "tax_id": 10116, "disease": "", "pathway": " (rno:681359)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7ENQ2-1", "uniprot_id": [ { "id": "F7ENQ2_RAT", "url": "https://www.uniprot.org/uniprot/F7ENQ2", "type": "external" } ], "mass": 42152.0, "length": 368, "protein_name": "RING finger protein 32", "gene_name": "Rnf32", "organism": "Rat", "refseq_name": "RING finger protein 32", "refseq_ac": [ { "id": "NP_001381954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381954", "type": "external" } ], "gene_names_uniprotkb": "Rnf32", "gene_names_refseq": "Rnf32", "protein_names_uniprotkb": "RING finger protein 32", "protein_names_refseq": "RING finger protein 32", "tax_id": 10116, "disease": "", "pathway": " (rno:311936)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in sperm formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0016235 aggresome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7ENQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EY92-1", "uniprot_id": [ { "id": "F7EY92_RAT", "url": "https://www.uniprot.org/uniprot/F7EY92", "type": "external" } ], "mass": 35225.0, "length": 314, "protein_name": "Methyl-CpG binding domain protein 3", "gene_name": "Mbd3", "organism": "Rat", "refseq_name": "methyl-CpG-binding domain protein 3 isoform 4", "refseq_ac": [ { "id": "NP_001426429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426429", "type": "external" } ], "gene_names_uniprotkb": "Mbd3", "gene_names_refseq": "Mbd3", "protein_names_uniprotkb": "Methyl-CpG binding domain protein 3", "protein_names_refseq": "methyl-CpG-binding domain protein 3 isoform 4", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (R-RNO-3214815); (R-RNO-6804758); (R-RNO-73762); (R-RNO-8943724); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "12672019;22673903;24991957;27650712", "class_list": "", "function": "Data demonstrate for the first time alterations in the MBD3 expression and DNA occupancy in the experimental model of epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Endogenous Mta1/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylase (Hdac)1/2, RbAp46/48, and Mbd3 in the rat cerebellum, [RefSeq, PubMed]; MBD3 displays a selective spatial and temporal pattern of expression in the embryonic and adult brain, thereby strengthening the possibility of MBD3 playing an important role in neuronal development GeneRIF: Methyl CpG binding protein 3 (Mecp3, MBD3)displays a selective spatial and temporal pattern of expression in the embryonic and adult brain, thereby strengthening the possibility of MBD3 playing an important role in neuronal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F7EY92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F350-1", "uniprot_id": [ { "id": "F7F350_RAT", "url": "https://www.uniprot.org/uniprot/F7F350", "type": "external" } ], "mass": 40797.0, "length": 360, "protein_name": "Synapse-associated protein 1", "gene_name": "Syap1", "organism": "Rat", "refseq_name": "synapse-associated protein 1", "refseq_ac": [ { "id": "NP_001382482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382482", "type": "external" } ], "gene_names_uniprotkb": "Syap1", "gene_names_refseq": "Syap1", "protein_names_uniprotkb": "Synapse-associated protein 1; BSD domain-containing signal transducer and Akt interactor protein", "protein_names_refseq": "synapse-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:302678)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0032869 cellular response to insulin stimulus;GO:0045600 positive regulation of fat cell differentiation;GO:0071902 positive regulation of protein serine/threonine kinase activity;GO:0071364 cellular response to epidermal growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7F350-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F6T0-1", "uniprot_id": [ { "id": "F7F6T0_RAT", "url": "https://www.uniprot.org/uniprot/F7F6T0", "type": "external" } ], "mass": 22206.0, "length": 196, "protein_name": "T cell receptor associated transmembrane adaptor 1", "gene_name": "Trat1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trat1", "gene_names_refseq": "", "protein_names_uniprotkb": "T cell receptor associated transmembrane adaptor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1257604); (R-RNO-202424); (R-RNO-6811558)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0034451 centriolar satellite", "go_biological_process": "GO:0050850 positive regulation of calcium-mediated signaling;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0001920 negative regulation of receptor recycling;GO:0051051 negative regulation of transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7F6T0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V638-1", "uniprot_id": [ { "id": "G3V638_RAT", "url": "https://www.uniprot.org/uniprot/G3V638", "type": "external" } ], "mass": 42630.0, "length": 378, "protein_name": "Fc epsilon receptor II", "gene_name": "Fcer2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fcer2", "gene_names_refseq": "", "protein_names_uniprotkb": "Fc epsilon receptor II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171075)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019863 IgE binding;GO:0002020 protease binding;GO:0030246 carbohydrate binding;GO:0019769 low-affinity IgE receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0042742 defense response to bacterium;GO:0042116 macrophage activation;GO:0160006 Fc receptor-mediated immune complex endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V638-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V665-1", "uniprot_id": [ { "id": "G3V665_RAT", "url": "https://www.uniprot.org/uniprot/G3V665", "type": "external" } ], "mass": 36094.0, "length": 329, "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "Castor2", "organism": "Rat", "refseq_name": "cytosolic arginine sensor for mTORC1 subunit 2", "refseq_ac": [ { "id": "NP_001094031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094031", "type": "external" } ], "gene_names_uniprotkb": "Castor2", "gene_names_refseq": "Castor2; Gatsl2; Gats", "protein_names_uniprotkb": "Cytosolic arginine sensor for mTORC1 subunit 2", "protein_names_refseq": "GATS protein-like 2; GATS-like protein 2; cytosolic arginine sensor for mTORC1 subunit 2; opposite strand transcription unit to Stag3", "tax_id": 10116, "disease": "", "pathway": " (rno:304410); (R-RNO-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1903577 cellular response to L-arginine;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V665-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V673-1", "uniprot_id": [ { "id": "G3V673_RAT", "url": "https://www.uniprot.org/uniprot/G3V673", "type": "external" } ], "mass": 101758.0, "length": 927, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5", "gene_name": "Adamts5", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor", "refseq_ac": [ { "id": "NP_942056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942056", "type": "external" } ], "gene_names_uniprotkb": "Adamts5", "gene_names_refseq": "Adamts5", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 5; ADMP-2; Aggrecanase-2", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)", "tax_id": 10116, "disease": "mucopolysaccharidosis VI (Disease Ontology:DOID:12800); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:304135); (R-RNO-1474228); (R-RNO-5173214)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16200461;16583222;17530714;24126801;28980719", "class_list": "", "function": "ADAMTS-5 mainly contributed to ECM metabolism in growth plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4 may be involved in ECM turn over in articular cartilage., [RefSeq, PubMed]; Dysregulated genes expressed in rats with surgically-induced osteoarthritis included Mmp13, Adamts5, Ptges, Cxcr4, Ccl2, and Col2a1., [RefSeq, PubMed]; MiR-132-3p promotes rat mesenchymal stem cell chondrogenic differentiation, possibly mediated by targeting ADAMTS-5, [RefSeq, PubMed]; OPG regulated the proliferation of chondrocytes via MEK/ERK signaling, and directly affected chondrocytes by influencing the expression profile of ADAMTS-5 and TIMP-4., [RefSeq, PubMed]; This study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0007520 myoblast fusion;GO:0003203 endocardial cushion morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V673-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V678-1", "uniprot_id": [ { "id": "G3V678_RAT", "url": "https://www.uniprot.org/uniprot/G3V678", "type": "external" } ], "mass": 17143.0, "length": 150, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "gene_name": "Polr2h", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "refseq_ac": [ { "id": "NP_001128261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128261", "type": "external" } ], "gene_names_uniprotkb": "Polr2h; AABR07030911.1", "gene_names_refseq": "Polr2h; RGD1561203; RPB17", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "protein_names_refseq": "DNA-directed RNA polymerases I, II, and III subunit RPABC3-like; DNA-directed RNA polymerases I, II, and III subunit RPABC3; RNA polymerase II subunit H; polymerase (RNA) II (DNA directed) polypeptide H; polymerase (RNA) II subunit H", "tax_id": 10116, "disease": "", "pathway": " (rno:498109); (R-RNO-112382); (R-RNO-113418); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 30, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003899 DNA-directed RNA polymerase activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex;GO:0005634 nucleus;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V678-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6A8-1", "uniprot_id": [ { "id": "G3V6A8_RAT", "url": "https://www.uniprot.org/uniprot/G3V6A8", "type": "external" } ], "mass": 369078.0, "length": 3228, "protein_name": "Golgin B1", "gene_name": "Golgb1", "organism": "Rat", "refseq_name": "golgin subfamily B member 1 isoform 2", "refseq_ac": [ { "id": "NP_001424645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424645", "type": "external" } ], "gene_names_uniprotkb": "Golgb1", "gene_names_refseq": "Golgb1", "protein_names_uniprotkb": "Golgin B1", "protein_names_refseq": "Golgin subfamily B member 1; golgi autoantigen, golgin subfamily b, macrogolgin 1; golgi-associated protein GCP360; golgin B1, golgi integral membrane protein; golgin subfamily B member 1 isoform 2", "tax_id": 10116, "disease": "hyperphosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0111063); osteochondrodysplasia (Disease Ontology:DOID:2256); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:192243); (R-RNO-432722); (R-RNO-6807878)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16641100;21851869;22673903;29577904;30453527;38843836", "class_list": "", "function": "Concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis, [RefSeq, PubMed]; Ethanol-induced Golgi disassembly was associated with de-dimerization of the largest Golgi matrix protein giantin, along with impaired transport of selected hepatic proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:1905793 protein localization to pericentriolar material;GO:0035988 chondrocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "G3V6A8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6C2-1", "uniprot_id": [ { "id": "G3V6C2_RAT", "url": "https://www.uniprot.org/uniprot/G3V6C2", "type": "external" } ], "mass": 49890.0, "length": 445, "protein_name": "Homogentisate 1,2-dioxygenase", "gene_name": "Hgd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hgd", "gene_names_refseq": "", "protein_names_uniprotkb": "Homogentisate 1,2-dioxygenase; 1.13.11.5; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase", "protein_names_refseq": "", "tax_id": 10116, "disease": "alkaptonuria (Disease Ontology:DOID:9270)", "pathway": " (R-RNO-8963684)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of homogentisate to maleylacetoacetate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.5", "type": "external" } ], "go_molecular_function": "GO:0004411 homogentisate 1,2-dioxygenase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006570 tyrosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6C2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6N5-1", "uniprot_id": [ { "id": "G3V6N5_RAT", "url": "https://www.uniprot.org/uniprot/G3V6N5", "type": "external" } ], "mass": 22767.0, "length": 202, "protein_name": "Solute carrier family 66 member 3", "gene_name": "Slc66a3", "organism": "Rat", "refseq_name": "solute carrier family 66 member 3 precursor", "refseq_ac": [ { "id": "NP_001030124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030124", "type": "external" } ], "gene_names_uniprotkb": "Slc66a3; Pqlc3", "gene_names_refseq": "Pqlc3; RGD1306818; Slc66a3", "protein_names_uniprotkb": "Solute carrier family 66 member 3", "protein_names_refseq": "PQ loop repeat containing 3; PQ-loop repeat-containing protein 3; solute carrier family 66 member 3 precursor", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); alcohol dependence (Disease Ontology:DOID:0050741); warfarin resistance (Disease Ontology:DOID:0080665); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); tuberculosis (Disease Ontology:DOID:399); hyperglycemia (Disease Ontology:DOID:4195); multiple chemical sensitivity (Disease Ontology:DOID:4661); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:298906)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6N5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6T8-1", "uniprot_id": [ { "id": "G3V6T8_RAT", "url": "https://www.uniprot.org/uniprot/G3V6T8", "type": "external" } ], "mass": 35777.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or2t1", "organism": "Rat", "refseq_name": "olfactory receptor Olr1606", "refseq_ac": [ { "id": "NP_001000502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000502", "type": "external" } ], "gene_names_uniprotkb": "Or2t1", "gene_names_refseq": "Olr1606; Or2t1; tpcr38", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1606; olfactory receptor Olr1606; olfactory receptor gene Olr1606", "tax_id": 10116, "disease": "", "pathway": " (rno:305711)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6T8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6Z2-1", "uniprot_id": [ { "id": "G3V6Z2_RAT", "url": "https://www.uniprot.org/uniprot/G3V6Z2", "type": "external" } ], "mass": 27640.0, "length": 237, "protein_name": "Potassium channel tetramerization domain containing 6", "gene_name": "Kctd6", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD6 isoform 1", "refseq_ac": [ { "id": "NP_001100723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100723", "type": "external" } ], "gene_names_uniprotkb": "Kctd6", "gene_names_refseq": "Kctd6", "protein_names_uniprotkb": "Potassium channel tetramerization domain containing 6", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD6 isoform 1; BTB/POZ domain-containing protein KCTD6; potassium channel tetramerisation domain containing 6", "tax_id": 10116, "disease": "", "pathway": " (rno:305792); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding;GO:0042802 identical protein binding;GO:0030506 ankyrin binding", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V6Z2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V727-1", "uniprot_id": [ { "id": "G3V727_RAT", "url": "https://www.uniprot.org/uniprot/G3V727", "type": "external" } ], "mass": 50989.0, "length": 457, "protein_name": "Probable ATP-dependent RNA helicase DDX47", "gene_name": "Ddx47", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddx47", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX47; 3.6.4.13; DEAD box protein 47", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:297685); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, 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"reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005634 nucleus", "go_biological_process": "GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V727-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7D5-1", "uniprot_id": [ { "id": "G3V7D5_RAT", "url": "https://www.uniprot.org/uniprot/G3V7D5", "type": "external" } ], "mass": 26212.0, "length": 230, "protein_name": "Tissue factor pathway inhibitor 2", "gene_name": "Tfpi2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tfpi2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tissue factor pathway inhibitor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:286926)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0071498 cellular response to fluid shear stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7D5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7E3-1", "uniprot_id": [ { "id": "G3V7E3_RAT", "url": "https://www.uniprot.org/uniprot/G3V7E3", "type": "external" } ], "mass": 28494.0, "length": 261, "protein_name": "Granzyme A", "gene_name": "Gzma", "organism": "Rat", "refseq_name": "granzyme A precursor", "refseq_ac": [ { "id": "NP_703198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703198", "type": "external" } ], "gene_names_uniprotkb": "Gzma", "gene_names_refseq": "Gzma", "protein_names_uniprotkb": "Granzyme A", "protein_names_refseq": "granzyme A precursor", "tax_id": 10116, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (rno:266708)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17213646", "class_list": "", "function": "Activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which ulcerative colitis markers, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042803 protein homodimerization activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0044194 cytolytic granule", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0009617 response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0051604 protein maturation;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V7E3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7I3-1", "uniprot_id": [ { "id": "G3V7I3_RAT", "url": "https://www.uniprot.org/uniprot/G3V7I3", "type": "external" } ], "mass": 131916.0, "length": 1197, "protein_name": "Endoplasmic reticulum transmembrane helix translocase", "gene_name": "Atp13a1", "organism": "Rat", "refseq_name": "endoplasmic reticulum transmembrane helix translocase", "refseq_ac": [ { "id": "NP_001099549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099549", "type": "external" } ], "gene_names_uniprotkb": "Atp13a1", "gene_names_refseq": "Atp13a1; Atp13a", "protein_names_uniprotkb": "Endoplasmic reticulum transmembrane helix translocase; Endoplasmic reticulum P5A-ATPase", "protein_names_refseq": "ATPase type 13A1; endoplasmic reticulum transmembrane helix translocase; manganese-transporting ATPase 13A1; probable cation-transporting ATPase 13A1", "tax_id": 10116, "disease": "", "pathway": " (rno:290673); (R-RNO-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum. Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane. Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0140569 extraction of mislocalized protein from ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7I3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7J7-1", "uniprot_id": [ { "id": "G3V7J7_RAT", "url": "https://www.uniprot.org/uniprot/G3V7J7", "type": "external" } ], "mass": 16793.0, "length": 153, "protein_name": "Eukaryotic translation initiation factor 5A", "gene_name": "Eif5a2", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 5A-2", "refseq_ac": [ { "id": "NP_001094167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094167", "type": "external" } ], "gene_names_uniprotkb": "Eif5a2", "gene_names_refseq": "Eif5a2; eIF5AII", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A; eIF-5A", "protein_names_refseq": "eukaryotic translation initiation factor 5A-2", "tax_id": 10116, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (rno:310261); (R-RNO-204626)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045901 positive regulation of translational elongation;GO:0045905 positive regulation of translational termination;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7J7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7N7-1", "uniprot_id": [ { "id": "G3V7N7_RAT", "url": "https://www.uniprot.org/uniprot/G3V7N7", "type": "external" } ], "mass": 116088.0, "length": 1018, "protein_name": "E3 SUMO-protein ligase ZNF451", "gene_name": "Zfp451", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp451", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 SUMO-protein ligase ZNF451; E3 SUMO-protein transferase ZNF451; Zinc finger protein 451", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:316312)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0016925 protein sumoylation;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060633 negative regulation of transcription initiation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7N7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7P2-1", "uniprot_id": [ { "id": "G3V7P2_RAT", "url": "https://www.uniprot.org/uniprot/G3V7P2", "type": "external" } ], "mass": 48656.0, "length": 429, "protein_name": "Fibrinogen-like 2", "gene_name": "Fgl2", "organism": "Rat", "refseq_name": "fibroleukin precursor", "refseq_ac": [ { "id": "NP_445907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445907", "type": "external" } ], "gene_names_uniprotkb": "Fgl2", "gene_names_refseq": "Fgl2", "protein_names_uniprotkb": "Fibrinogen-like 2", "protein_names_refseq": "fibroleukin precursor; fibroleukin", "tax_id": 10116, "disease": "autoimmune glomerulonephritis (Disease Ontology:DOID:0040094)", "pathway": " (rno:84586); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12593995;21063837;22387586;22456282;26482204;28892130;29128901;36508913", "class_list": "", "function": "Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis., [RefSeq, PubMed]; FGL2 plays an important role in the pathogenesis of autoimmune myocarditis that also involves the PD-1/PD-L1 pathway. Our findings may provide novel therapeutic targets for the treatment of immune-induced heart injury., [RefSeq, PubMed]; Fgl2 prothrombinase is involved in severe acute pancreatitis-associated liver injury., [RefSeq, PubMed]; In rats with type 2 diabetes, microthrombosis due to fgl2 contributes to the impairment of cardiac diastolic or systolic function and morphological changes., [RefSeq, PubMed]; Microthrombosis is involved in cardiac microvascular dysfunction or disturbance of rats with acute MI/R as one cause, and fgl2 may emerge as a predictor of the occurrence of no-reflow phenomenon., [RefSeq, PubMed]; STS is able to ameliorate CNR through inhibition of FGL2 expression mediated by Akt and NF-kappaB pathways as well as prevention of MVO by suppressing fibrin deposition and inflammation., [RefSeq, PubMed]; Studies confirmed the expression of Fgl-2 mRNA in several rat tissues, including the pregnant uterus, where it could play a key role in the initiation of parturition especially in response to local or systemic infection, [RefSeq, PubMed]; This study shows that FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016504 peptidase activator activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007596 blood coagulation;GO:0007567 parturition;GO:0050687 negative regulation of defense response to virus;GO:0002605 negative regulation of dendritic cell antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "G3V7P2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Q9-1", "uniprot_id": [ { "id": "G3V7Q9_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Q9", "type": "external" } ], "mass": 65621.0, "length": 576, "protein_name": "Trehalase", "gene_name": "Treh", "organism": "Rat", "refseq_name": "trehalase precursor", "refseq_ac": [ { "id": "NP_001129613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129613", "type": "external" } ], "gene_names_uniprotkb": "Treh", "gene_names_refseq": "Treh", "protein_names_uniprotkb": "Trehalase; 3.2.1.28; Alpha-trehalose glucohydrolase", "protein_names_refseq": "trehalase (brush-border membrane glycoprotein); trehalase precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:60576)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.28", "type": "external" } ], "go_molecular_function": "GO:0004555 alpha,alpha-trehalase activity", "go_cellular_component": "", "go_biological_process": "GO:0009887 animal organ morphogenesis;GO:0005993 trehalose catabolic process;GO:0005991 trehalose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7Q9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7R6-1", "uniprot_id": [ { "id": "G3V7R6_RAT", "url": "https://www.uniprot.org/uniprot/G3V7R6", "type": "external" } ], "mass": 49103.0, "length": 430, "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "Tnip2", "organism": "Rat", "refseq_name": "TNFAIP3-interacting protein 2", "refseq_ac": [ { "id": "NP_001381613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381613", "type": "external" } ], "gene_names_uniprotkb": "Tnip2", "gene_names_refseq": "Tnip2", "protein_names_uniprotkb": "TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2", "protein_names_refseq": "TNFAIP3-interacting protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:305451); (R-RNO-5684264); (R-RNO-5689896)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "30720079;37329819", "class_list": "", "function": "Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes., [UniProtKB, UniProtKB]; Protective effect of TNIP2 on the inflammatory response of microglia after spinal cord injury in rats., [RefSeq, PubMed]; The data indicated that TNIP2 is significantly decreased in MODS following severe trauma, and it plays a protective role in MODS development by inhibiting the inflammation response and oxidative stress by preventing NFkappaB activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V7E7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0070498 interleukin-1-mediated signaling pathway;GO:0023035 CD40 signaling pathway;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V7R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7T4-1", "uniprot_id": [ { "id": "G3V7T4_RAT", "url": "https://www.uniprot.org/uniprot/G3V7T4", "type": "external" } ], "mass": 43885.0, "length": 399, "protein_name": "MYCL proto-oncogene, bHLH transcription factor", "gene_name": "Mycl", "organism": "Rat", "refseq_name": "protein L-Myc isoform 2", "refseq_ac": [ { "id": "NP_001398532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001398532", "type": "external" } ], "gene_names_uniprotkb": "Mycl; Mycl1", "gene_names_refseq": "Lmyc1; Mycl1; Mycl", "protein_names_uniprotkb": "MYCL proto-oncogene, bHLH transcription factor", "protein_names_refseq": "Avian myelocytomatosis viral (v-myc) related oncogene homolog 1, lung carcinoma derived (Lmyc); protein L-Myc isoform 2; protein L-Myc-1; v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045607 regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7T4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7U3-1", "uniprot_id": [ { "id": "G3V7U3_RAT", "url": "https://www.uniprot.org/uniprot/G3V7U3", "type": "external" } ], "mass": 45564.0, "length": 406, "protein_name": "Protein Wnt", "gene_name": "Wnt2b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wnt2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774); endodermal sinus tumor (Disease Ontology:DOID:1911); teratoma (Disease Ontology:DOID:3307)", "pathway": " (rno:116466); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0060638 mesenchymal-epithelial cell signaling;GO:0008584 male gonad development;GO:0030182 neuron differentiation;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7U3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Y8-1", "uniprot_id": [ { "id": "G3V7Y8_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Y8", "type": "external" } ], "mass": 24004.0, "length": 198, "protein_name": "Single-stranded DNA cytosine deaminase", "gene_name": "Aicda", "organism": "Rat", "refseq_name": "single-stranded DNA cytosine deaminase", "refseq_ac": [ { "id": "NP_001094249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094249", "type": "external" } ], "gene_names_uniprotkb": "Aicda; aicda", "gene_names_refseq": "Aicda; aid", "protein_names_uniprotkb": "Single-stranded DNA cytosine deaminase; 3.5.4.38; Activation-induced cytidine deaminase; Cytidine aminohydrolase", "protein_names_refseq": "single-stranded DNA cytosine deaminase", "tax_id": 10116, "disease": "swine influenza (Disease Ontology:DOID:0050211); immunodeficiency with hyper-IgM type 2 (Disease Ontology:DOID:0060758); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); hyperimmunoglobulin syndrome (Disease Ontology:DOID:2959); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:399679)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7Y8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V815-1", "uniprot_id": [ { "id": "G3V815_RAT", "url": "https://www.uniprot.org/uniprot/G3V815", "type": "external" } ], "mass": 38197.0, "length": 342, "protein_name": "Homeobox protein Hox-C10", "gene_name": "Hoxc10", "organism": "Rat", "refseq_name": "homeobox protein Hox-C10", "refseq_ac": [ { "id": "NP_001295565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295565", "type": "external" } ], "gene_names_uniprotkb": "Hoxc10", "gene_names_refseq": "Hoxc10", "protein_names_uniprotkb": "Homeobox protein Hox-C10", "protein_names_refseq": "Hox3.5 homeobox; homeobox protein Hox-C10", "tax_id": 10116, "disease": "", "pathway": " (rno:315338)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;33369800", "class_list": "", "function": "Homeobox A5 and C10 genes modulate adaptation of brown adipose tissue during exercise training in juvenile rats., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V815-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V830-1", "uniprot_id": [ { "id": "G3V830_RAT", "url": "https://www.uniprot.org/uniprot/G3V830", "type": "external" } ], "mass": 63285.0, "length": 567, "protein_name": "Interleukin-10 receptor subunit alpha", "gene_name": "Il10ra", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il10ra", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-10 receptor subunit alpha; CDw210a; Interleukin-10 receptor subunit 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease 28 (Disease Ontology:DOID:0110899)", "pathway": " (rno:117539); (R-RNO-6783783)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019969 interleukin-10 binding;GO:0004920 interleukin-10 receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:1905571 interleukin-10 receptor complex", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0050728 negative regulation of inflammatory response;GO:0010507 negative regulation of autophagy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V830-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8B7-1", "uniprot_id": [ { "id": "G3V8B7_RAT", "url": "https://www.uniprot.org/uniprot/G3V8B7", "type": "external" } ], "mass": 35612.0, "length": 321, "protein_name": "Olfactory receptor", "gene_name": "Olr36; Or2at1", "organism": "Rat", "refseq_name": "olfactory receptor Olr37", "refseq_ac": [ { "id": "NP_001000504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000504", "type": "external" } ], "gene_names_uniprotkb": "Olr36; Or2at1; Olr36", "gene_names_refseq": "Olr37; Or2at1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 37; olfactory receptor Olr37; olfactory receptor gene Olr37", "tax_id": 10116, "disease": "", "pathway": " (rno:308853); (rno:405257)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8B7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8J2-1", "uniprot_id": [ { "id": "G3V8J2_RAT", "url": "https://www.uniprot.org/uniprot/G3V8J2", "type": "external" } ], "mass": 63267.0, "length": 551, "protein_name": "Cytochrome P450 family 8 subfamily B member 1", "gene_name": "Cyp8b1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp8b1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 family 8 subfamily B member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "extrahepatic cholestasis (Disease Ontology:DOID:13619)", "pathway": " (rno:81924); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-211979); (R-RNO-211994); (R-RNO-2162123)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008397 sterol 12-alpha-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0031667 response to nutrient levels;GO:0070723 response to cholesterol;GO:0045797 positive regulation of intestinal cholesterol absorption", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8J2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8S9-1", "uniprot_id": [ { "id": "G3V8S9_RAT", "url": "https://www.uniprot.org/uniprot/G3V8S9", "type": "external" } ], "mass": 19756.0, "length": 175, "protein_name": "Cathelicidin antimicrobial peptide", "gene_name": "Camp", "organism": "Rat", "refseq_name": "cathelicidin antimicrobial peptide precursor", "refseq_ac": [ { "id": "NP_001094194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094194", "type": "external" } ], "gene_names_uniprotkb": "Camp", "gene_names_refseq": "CRAMP; Camp", "protein_names_uniprotkb": "Cathelicidin antimicrobial peptide", "protein_names_refseq": "cathelicidin antimicrobial peptide precursor; cathelin-related antimicrobial peptide", "tax_id": 10116, "disease": "dentin caries (Disease Ontology:DOID:10461); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:316010); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042581 specific granule;GO:0042995 cell projection", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0097187 dentinogenesis;GO:0002760 positive regulation of antimicrobial humoral response;GO:0001934 positive regulation of protein phosphorylation;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8S9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8W9-1", "uniprot_id": [ { "id": "G3V8W9_RAT", "url": "https://www.uniprot.org/uniprot/G3V8W9", "type": "external" } ], "mass": 17536.0, "length": 157, "protein_name": "Thiosulfate sulfurtransferase like domain containing 3", "gene_name": "Tstd3", "organism": "Rat", "refseq_name": "thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3", "refseq_ac": [ { "id": "NP_001094267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094267", "type": "external" } ], "gene_names_uniprotkb": "Tstd3", "gene_names_refseq": "Tstd3", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase like domain containing 3", "protein_names_refseq": "thiosulfate sulfurtransferase (rhodanese)-like domain containing 3; thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:500420)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8W9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V906-1", "uniprot_id": [ { "id": "G3V906_RAT", "url": "https://www.uniprot.org/uniprot/G3V906", "type": "external" } ], "mass": 39962.0, "length": 351, "protein_name": "Hydroxycarboxylic acid receptor 1", "gene_name": "Hcar1", "organism": "Rat", "refseq_name": "hydroxycarboxylic acid receptor 1", "refseq_ac": [ { "id": "NP_001138806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138806", "type": "external" } ], "gene_names_uniprotkb": "Hcar1", "gene_names_refseq": "Gpr81; Hcar1", "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 1", "protein_names_refseq": "G protein-coupled receptor 81; hydroxycarboxylic acid receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:689936); (R-RNO-3296197); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "25495836;31881352;35240875;35856408;38294536", "class_list": "", "function": "Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue., [RefSeq, PubMed]; Adiposederived mesenchymal stem cellderived HCAR1 regulates immune response in the attenuation of sepsis., [RefSeq, PubMed]; Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling., [RefSeq, PubMed]; Results indicate that lactate may aggravated ischemic brain injury by activating GPR81 and inhibition of GPR81 protects against ischemia-induced cell death via an antiapoptosis pathway, [RefSeq, PubMed]; Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0050995 negative regulation of lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V906-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9A0-1", "uniprot_id": [ { "id": "G3V9A0_RAT", "url": "https://www.uniprot.org/uniprot/G3V9A0", "type": "external" } ], "mass": 144300.0, "length": 1346, "protein_name": "Pleckstrin homology and RhoGEF domain containing G2", "gene_name": "Plekhg2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plekhg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology and RhoGEF domain containing G2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:292750); (R-RNO-193648); (R-RNO-416482); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V9A0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9M1-1", "uniprot_id": [ { "id": "G3V9M1_RAT", "url": "https://www.uniprot.org/uniprot/G3V9M1", "type": "external" } ], "mass": 95497.0, "length": 819, "protein_name": "Probable ATP-dependent RNA helicase DDX23", "gene_name": "Ddx23", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX23", "refseq_ac": [ { "id": "NP_001100263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100263", "type": "external" } ], "gene_names_uniprotkb": "Ddx23", "gene_names_refseq": "Ddx23", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX23; 3.6.4.13; DEAD box protein 23", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; probable ATP-dependent RNA helicase DDX23", "tax_id": 10116, "disease": "", "pathway": " (rno:300208); (R-RNO-72165)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0000785 chromatin", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0062176 R-loop processing;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V9M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9M6-1", "uniprot_id": [ { "id": "G3V9M6_RAT", "url": "https://www.uniprot.org/uniprot/G3V9M6", "type": "external" } ], "mass": 311953.0, "length": 2872, "protein_name": "Fibrillin-1", "gene_name": "Fbn1", "organism": "Rat", "refseq_name": "fibrillin-1 precursor", "refseq_ac": [ { "id": "NP_114013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114013", "type": "external" } ], "gene_names_uniprotkb": "Fbn1", "gene_names_refseq": "Fbn1", "protein_names_uniprotkb": "Fibrillin-1", "protein_names_refseq": "fibrillin-1 precursor", "tax_id": 10116, "disease": "Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); CREST syndrome (Disease Ontology:DOID:0060218); scoliosis (Disease Ontology:DOID:0060249); aortic dissection (Disease Ontology:DOID:0080685); autosomal dominant isolated ectopia lentis 1 (Disease Ontology:DOID:0111150); acromicric dysplasia (Disease Ontology:DOID:0111243); stiff skin syndrome (Disease Ontology:DOID:0111561); geleophysic dysplasia 2 (Disease Ontology:DOID:0111726); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); Marfan syndrome (Disease Ontology:DOID:14323); glomerulonephritis (Disease Ontology:DOID:2921); mixed connective tissue disease (Disease Ontology:DOID:3492); aortic aneurysm (Disease Ontology:DOID:3627); systemic scleroderma (Disease Ontology:DOID:418); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); liver cirrhosis (Disease Ontology:DOID:5082); type 2 diabetes mellitus (Disease Ontology:DOID:9352); refractive error (Disease Ontology:DOID:9835); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (rno:83727); (R-RNO-1474228); (R-RNO-1566948); (R-RNO-2129379); (R-RNO-216083); (R-RNO-2173789); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "22673903;33781005;35462799;36693798;37532137;38069063", "class_list": "", "function": "Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models., [RefSeq, PubMed]; FBN1 knockout promotes cervical artery dissection by inducing N-glycosylation alternation of extracellular matrix proteins in rat VSMCs., [RefSeq, PubMed]; Increased RBP4 and Asprosin Are Novel Contributors in Inflammation Process of Periodontitis in Obese Rats. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats. 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Tact3 proteins might play an important role in rodent germ-cell development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "M0R682-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R6S6-1", "uniprot_id": [ { "id": "M0R6S6_RAT", "url": "https://www.uniprot.org/uniprot/M0R6S6", "type": "external" } ], "mass": 25252.0, "length": 215, "protein_name": "Uncharacterized LOC134480503", "gene_name": "1700001E04Rikl; Ccdc88al1; Girdinl1; LOC102557419; LOC120094615; LOC134480503; LOC691414; Spetex2dl2; Spetex2el6; Spetex2l1; Spetex2l2", "organism": "Rat", "refseq_name": "uncharacterized protein Spetex2l2 isoform X2", "refseq_ac": [ { "id": "XP_038940306", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038940306", "type": "external" } ], "gene_names_uniprotkb": "1700001E04Rikl; Ccdc88al1; Girdinl1; LOC102557419; LOC120094615; LOC134480503; LOC691414; Spetex2dl2; Spetex2el6; Spetex2l1; Spetex2l2; 1700001E04Rikl; Girdinl1; LOC100360856; LOC120093101; LOC120094604; LOC120094605; LOC134480310; LOC134480503; LOC134480542; LOC302192; LOC685668; LOC691491; MGC116197; Spetex2l1", "gene_names_refseq": "Spetex2l2", "protein_names_uniprotkb": "Uncharacterized LOC134480503", "protein_names_refseq": "uncharacterized protein Spetex2l2 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:302192); (rno:367620); (rno:685668)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R6S6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R6T8-1", "uniprot_id": [ { "id": "M0R6T8_RAT", "url": "https://www.uniprot.org/uniprot/M0R6T8", "type": "external" } ], "mass": 129027.0, "length": 1169, "protein_name": "Integrin subunit alpha E", "gene_name": "Itgae", "organism": "Rat", "refseq_name": "integrin alpha-E precursor", "refseq_ac": [ { "id": "NP_113956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113956", "type": "external" } ], "gene_names_uniprotkb": "Itgae", "gene_names_refseq": "Itgae", "protein_names_uniprotkb": "Integrin subunit alpha E", "protein_names_refseq": "integrin alpha E1, epithelial-associated; integrin alpha-E precursor; integrin, alpha E, epithelial-associated", "tax_id": 10116, "disease": "", "pathway": " (rno:83577); (R-RNO-216083)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16547225;29393594;35042191", "class_list": "", "function": "Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis., [RefSeq, PubMed]; Transfer of tolerance requires the presence of both T cells and CD103(+) dendritic cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0008305 integrin complex;GO:0034691 integrin alphaE-beta7 complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0R6T8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R722-1", "uniprot_id": [ { "id": "M0R722_RAT", "url": "https://www.uniprot.org/uniprot/M0R722", "type": "external" } ], "mass": 34904.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or1aa2", "organism": "Rat", "refseq_name": "olfactory receptor Olr1751", "refseq_ac": [ { "id": "NP_001000492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000492", "type": "external" } ], "gene_names_uniprotkb": "Or1aa2", "gene_names_refseq": "Olr1751; Or1aa2; ratchrX-13766579-13765641_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1751; olfactory receptor Olr1751; olfactory receptor gene Olr1751", "tax_id": 10116, "disease": "", "pathway": " (rno:302825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R722-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R729-1", "uniprot_id": [ { "id": "M0R729_RAT", "url": "https://www.uniprot.org/uniprot/M0R729", "type": "external" } ], "mass": 18920.0, "length": 170, "protein_name": "Zinc finger CCHC-type containing 13", "gene_name": "Zcchc13", "organism": "Rat", "refseq_name": "zinc finger CCHC domain-containing protein 13", "refseq_ac": [ { "id": "NP_001388052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388052", "type": "external" } ], "gene_names_uniprotkb": "Zcchc13; LOC302399", "gene_names_refseq": "Zcchc13", "protein_names_uniprotkb": "Zinc finger CCHC-type containing 13", "protein_names_refseq": "zinc finger CCHC domain-containing protein 13; zinc finger, CCHC domain containing 13", "tax_id": 10116, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (rno:302399)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R729-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7E5-1", "uniprot_id": [ { "id": "M0R7E5_RAT", "url": "https://www.uniprot.org/uniprot/M0R7E5", "type": "external" } ], "mass": 14031.0, "length": 120, "protein_name": "60S ribosomal protein L36a-like", "gene_name": "LOC100910714", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL42-like", "refseq_ac": [ { "id": "XP_003751267", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751267", "type": "external" } ], "gene_names_uniprotkb": "LOC100910714", "gene_names_refseq": "LOC100910714", "protein_names_uniprotkb": "60S ribosomal protein L36a-like", "protein_names_refseq": "large ribosomal subunit protein eL42-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100910714); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R7E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R854-1", "uniprot_id": [ { "id": "M0R854_RAT", "url": "https://www.uniprot.org/uniprot/M0R854", "type": "external" } ], "mass": 27715.0, "length": 248, "protein_name": "Keratin-associated protein", "gene_name": "Krtap24-1", "organism": "Rat", "refseq_name": "keratin associated protein 24-1", "refseq_ac": [ { "id": "NP_001419577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419577", "type": "external" } ], "gene_names_uniprotkb": "Krtap24-1; LOC100364550", "gene_names_refseq": "Krtap24-1", "protein_names_uniprotkb": "Keratin-associated protein", "protein_names_refseq": "keratin associated protein 24-1", "tax_id": 10116, "disease": "", "pathway": " (rno:100364550); (R-RNO-6805567)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. 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Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RA14-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RA43-1", "uniprot_id": [ { "id": "M0RA43_RAT", "url": "https://www.uniprot.org/uniprot/M0RA43", "type": "external" } ], "mass": 53186.0, "length": 466, "protein_name": "Zinc finger protein interacting with ribonucleoprotein K", "gene_name": "Zik1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zik1", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein interacting with ribonucleoprotein K", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-212436)", 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"ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008158 hedgehog receptor activity;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008544 epidermis development;GO:0001558 regulation of cell growth;GO:0045606 positive regulation of epidermal cell differentiation;GO:0043588 skin development;GO:0001709 cell fate determination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0RA51-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RA77-1", "uniprot_id": [ { "id": "M0RA77_RAT", "url": "https://www.uniprot.org/uniprot/M0RA77", "type": "external" } ], "mass": 30509.0, "length": 274, "protein_name": "Phospholipid scramblase", "gene_name": "Plscr5", "organism": "Rat", "refseq_name": "phospholipid scramblase family member 5", "refseq_ac": [ { "id": "NP_001178928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178928", "type": "external" } ], "gene_names_uniprotkb": "Plscr5", "gene_names_refseq": "Plscr5; RGD1564500", "protein_names_uniprotkb": "Phospholipid scramblase", "protein_names_refseq": "phospholipid scramblase family member 5", "tax_id": 10116, "disease": "", "pathway": " (rno:501036)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RA77-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAD5-1", "uniprot_id": [ { "id": "M0RAD5_RAT", "url": "https://www.uniprot.org/uniprot/M0RAD5", "type": "external" } ], "mass": 36208.0, "length": 333, "protein_name": "ATP-dependent Clp protease proteolytic subunit", "gene_name": "Clpp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clpp", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent Clp protease proteolytic subunit; 3.4.21.92", "protein_names_refseq": "", "tax_id": 10116, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857)", "pathway": " (R-RNO-9837999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The ClpXP complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0009368 endopeptidase Clp complex", "go_biological_process": "GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process;GO:0033619 membrane protein proteolysis;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RAD5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAL3-1", "uniprot_id": [ { "id": "M0RAL3_RAT", "url": "https://www.uniprot.org/uniprot/M0RAL3", "type": "external" } ], "mass": 36087.0, "length": 334, "protein_name": "Protease, serine, 32", "gene_name": "Prss32", "organism": "Rat", "refseq_name": "protease, serine, 32 precursor", "refseq_ac": [ { "id": "NP_001100453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100453", "type": "external" } ], "gene_names_uniprotkb": "Prss32", "gene_names_refseq": "Prss32", "protein_names_uniprotkb": "Protease, serine, 32", "protein_names_refseq": "protease, serine, 32 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:302970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RAL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAV4-1", "uniprot_id": [ { "id": "M0RAV4_RAT", "url": "https://www.uniprot.org/uniprot/M0RAV4", "type": "external" } ], "mass": 34192.0, "length": 306, "protein_name": "Olfactory receptor", "gene_name": "Or2ak6e", "organism": "Rat", "refseq_name": "olfactory receptor Olr1434", "refseq_ac": [ { 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Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex;GO:1990062 RPAP3/R2TP/prefoldin-like complex", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:1905907 negative regulation of amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MGC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6T9-1", "uniprot_id": [ { "id": "Q6P6T9_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6T9", "type": "external" } ], "mass": 58151.0, "length": 532, "protein_name": "Importin subunit alpha", "gene_name": "Kpna2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kpna2", "gene_names_refseq": "", "protein_names_uniprotkb": "Importin subunit alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:85245); (R-RNO-5693548)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HK66", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity;GO:0042826 histone deacetylase binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex;GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0006886 intracellular protein transport;GO:0032481 positive regulation of type I interferon production;GO:1903902 positive regulation of viral life cycle;GO:0046015 regulation of transcription by glucose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6T9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI08-1", "uniprot_id": [ { "id": "Q6QI08_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI08", "type": "external" } ], "mass": 10451.0, "length": 96, "protein_name": "Uncharacterized LOC100909680", "gene_name": "LOC100909680", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC100909680", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized LOC100909680", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI08-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI19-1", "uniprot_id": [ { "id": "Q6QI19_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI19", "type": "external" } ], "mass": 15542.0, "length": 139, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, 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"go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI19-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI72-1", "uniprot_id": [ { "id": "Q6QI72_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI72", "type": "external" } ], "mass": 48145.0, "length": 436, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI72-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI85-1", "uniprot_id": [ { "id": "Q6QI85_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI85", "type": "external" } ], "mass": 9935.0, "length": 92, "protein_name": "Uncharacterized LOC100912266", "gene_name": "LOC100912266", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC100912266", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized LOC100912266", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, 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"secondary_ac_list": "A6I4Y5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI85-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6U2D6-1", "uniprot_id": [ { "id": "Q6U2D6_RAT", "url": "https://www.uniprot.org/uniprot/Q6U2D6", "type": "external" } ], "mass": 42822.0, "length": 378, "protein_name": "C-C motif chemokine receptor 7", "gene_name": "Ccr7", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 7 precursor", "refseq_ac": [ { "id": "NP_955783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955783", "type": "external" } ], "gene_names_uniprotkb": "Ccr7", "gene_names_refseq": "Ccr7", "protein_names_uniprotkb": "C-C motif chemokine receptor 7", "protein_names_refseq": "C-C chemokine receptor type 7 precursor; C-C chemokine receptor type 7; chemokine (C-C motif) receptor 7", "tax_id": 10116, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); pulmonary sarcoidosis (Disease Ontology:DOID:13406); pneumonia (Disease Ontology:DOID:552)", "pathway": " (rno:287673); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "25086360;28035134;29077526", "class_list": "", "function": "CCL19/CCR7 contributes to the migration of bone marrow mesenchymal stem cells by upregulating MMP9 potentially via the PI3K/Akt pathway., [RefSeq, PubMed]; These results suggest that upregulation of rat CCR7 expression does not change the phenotype, differentiation, or proliferation capacity of human adipose-derived stem cells (hASCs), but does enable efficient migration of hASCs to rat secondary lymphoid organs. Publication Status: Online-Only, [RefSeq, PubMed]; This study shows induction of renal CCR7 expression in the Model of Anti-Thy1.1 Mesangioproliferative Glomerulonephritis in rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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concentration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6U2D6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XLI7-1", "uniprot_id": [ { "id": "Q6XLI7_RAT", "url": "https://www.uniprot.org/uniprot/Q6XLI7", "type": "external" } ], "mass": 106262.0, "length": 1032, "protein_name": "RNA-binding protein 12", "gene_name": "Rbm12", "organism": "Rat", "refseq_name": "RNA-binding protein 12", "refseq_ac": [ { "id": "NP_001032746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032746", "type": "external" } ], "gene_names_uniprotkb": "Rbm12", "gene_names_refseq": "Rbm12", "protein_names_uniprotkb": "RNA-binding protein 12; RNA-binding motif protein 12", "protein_names_refseq": "RNA-binding protein 12; swan", "tax_id": 10116, "disease": "schizophrenia 19 (Disease Ontology:DOID:0080281)", "pathway": " (rno:652928)", "pathway_count": 1, 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"https://www.ncbi.nlm.nih.gov/protein/NP_001292206", "type": "external" } ], "gene_names_uniprotkb": "C17h6orf62; LOC100911664", "gene_names_refseq": "C17h6orf62", "protein_names_uniprotkb": "Similar to human chromosome 6 open reading frame 62", "protein_names_refseq": "uncharacterized protein C6orf62 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100911664)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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"url": "https://www.uniprot.org/uniprot/Q7TPB7", "type": "external" } ], "mass": 19196.0, "length": 176, "protein_name": "Mal, T-cell differentiation protein 2", "gene_name": "Mal2", "organism": "Rat", "refseq_name": "protein MAL2", "refseq_ac": [ { "id": "NP_942081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942081", "type": "external" } ], "gene_names_uniprotkb": "Mal2", "gene_names_refseq": "Mal2", "protein_names_uniprotkb": "Mal, T-cell differentiation protein 2", "protein_names_refseq": "MAL2 proteolipid protein; MAL2A; protein MAL2-like; protein MAL2", "tax_id": 10116, "disease": "", "pathway": " (rno:362911)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20053882;20444237", "class_list": "", "function": "Data show that in addition to its role in transcytosis, MAL2 also regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane., [RefSeq, PubMed]; MAL2 is a novel synaptic vesicle protein that is preferentially associated with vesicular glutamate (VGLUT-1)-containing nerve terminals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6HRF9", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0045121 membrane raft;GO:0030672 synaptic vesicle membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TPB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPI6-1", "uniprot_id": [ { "id": "Q7TPI6_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPI6", "type": "external" } ], "mass": 25401.0, "length": 219, "protein_name": "Uncharacterized protein", "gene_name": "", 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"https://www.uniprot.org/uniprot/Q8VHF9", "type": "external" } ], "mass": 87916.0, "length": 785, "protein_name": "Protein Wnt", "gene_name": "Asz1; Wnt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Asz1; Wnt2; Asz1; Wnt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); urinary system cancer (Disease Ontology:DOID:3996); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:114487); (rno:170578)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IE39", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0071546 pi-body;GO:0031012 extracellular matrix", "go_biological_process": "GO:0048731 system development;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0016055 Wnt signaling pathway;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925A6-1", "uniprot_id": [ { "id": "Q925A6_RAT", "url": "https://www.uniprot.org/uniprot/Q925A6", "type": "external" } ], "mass": 39440.0, "length": 374, "protein_name": "Doublesex and mab-3 related transcription factor 1", "gene_name": "Dmrt1", "organism": "Rat", "refseq_name": "doublesex- and mab-3-related transcription factor 1", "refseq_ac": [ { "id": "NP_446158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446158", "type": "external" } ], "gene_names_uniprotkb": "Dmrt1", "gene_names_refseq": "Dmrt1", "protein_names_uniprotkb": "Doublesex and mab-3 related transcription factor 1", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 1", "tax_id": 10116, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:114498)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11870074", "class_list": "", "function": "Sp1, Sp3, and Egr1 transcription factors play a critical role in Dmrt1 regulation in the testis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0003006 developmental process involved in reproduction;GO:0046661 male sex differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q925A6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JD1-1", "uniprot_id": [ { "id": "Q99JD1_RAT", "url": "https://www.uniprot.org/uniprot/Q99JD1", "type": "external" } ], "mass": 11025.0, "length": 111, "protein_name": "Beta-defensin", "gene_name": "Defb22", "organism": "Rat", "refseq_name": "beta-defensin 126 precursor", "refseq_ac": [ { "id": "NP_599218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599218", "type": "external" } ], "gene_names_uniprotkb": "Defb22", "gene_names_refseq": "2D6glycoprotein; Defb22", "protein_names_uniprotkb": "Beta-defensin", "protein_names_refseq": "2D6 glycoprotein; E-3 epididymal fluid protein; beta-defensin 126 precursor; beta-defensin 126; beta-defensin 22", "tax_id": 10116, "disease": "", "pathway": " (rno:171412)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21151152", "class_list": "", "function": "Demonstrated the antimicrobial activity of recombinant beta-defensin 22 against E coli and Candida albicans. It has lectin-like ability, binding to heparin beads. This heparin-binding activity implies potential roles in fertilisation capabilities of sperm., [RefSeq, PubMed]; Has antibacterial activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030112 glycocalyx;GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99JD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ9-1", "uniprot_id": [ { "id": "Q9WTQ9_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ9", "type": "external" } ], "mass": 32381.0, "length": 299, "protein_name": "Cone-rod homeobox protein", "gene_name": "Crx", "organism": "Rat", "refseq_name": "cone-rod homeobox protein", "refseq_ac": [ { "id": "NP_068627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068627", "type": "external" } ], "gene_names_uniprotkb": "Crx", "gene_names_refseq": "Crx", "protein_names_uniprotkb": "Cone-rod homeobox protein", "protein_names_refseq": "cone-rod homeobox containing; cone-rod homeobox protein", "tax_id": 10116, "disease": "Leber congenital amaurosis 7 (Disease Ontology:DOID:0110333); cone-rod dystrophy 2 (Disease Ontology:DOID:0111005); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:60446)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24877634;30803008", "class_list": "", "function": "The results suggest that Otx2 and Crx, both alone and in combination, act to control pineal melatonin synthesis., [RefSeq, PubMed]; The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis, [RefSeq, PubMed]; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LPR9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0043522 leucine zipper domain binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0046534 positive regulation of photoreceptor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WTQ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJE4-1", "uniprot_id": [ { "id": "A0A096MJE4_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJE4", "type": "external" } ], "mass": 24898.0, "length": 223, "protein_name": "Cytotoxic T-lymphocyte protein 4", "gene_name": "Ctla4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctla4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); latent autoimmune diabetes in adults (Disease Ontology:DOID:0080846); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); silicosis (Disease Ontology:DOID:10325); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); hepatitis A (Disease Ontology:DOID:12549); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); urinary schistosomiasis (Disease Ontology:DOID:1394); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune hemolytic anemia (Disease Ontology:DOID:718); autoimmune thyroiditis (Disease Ontology:DOID:7188); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (R-RNO-389356); (R-RNO-389513)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 49, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0045334 clathrin-coated endocytic vesicle", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0006974 DNA damage response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MJE4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJZ8-1", "uniprot_id": [ { "id": "A0A096MJZ8_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJZ8", "type": "external" } ], "mass": 192027.0, "length": 1690, "protein_name": "Lysine-specific demethylase 5A", "gene_name": "Kdm5a", "organism": "Rat", "refseq_name": "lysine-specific demethylase 5A isoform 1", "refseq_ac": [ { "id": "NP_001264106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264106", "type": "external" } ], "gene_names_uniprotkb": "Kdm5a", "gene_names_refseq": "Jarid1a; Kdm5a", "protein_names_uniprotkb": "Lysine-specific demethylase 5A; 1.14.11.67; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2; [histone H3]-trimethyl-L-lysine(4) demethylase 5A", "protein_names_refseq": "jumonji, AT rich interactive domain 1A (Rbp2 like); lysine (K)-specific demethylase 5A; lysine-specific demethylase 5A isoform 1; lysine-specific demethylase 5A", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); syndromic X-linked intellectual disability Claes-Jensen type (Disease Ontology:DOID:0060809); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); cryptorchidism (Disease Ontology:DOID:11383); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); stomach carcinoma (Disease Ontology:DOID:5517); ankylosing spondylitis (Disease Ontology:DOID:7147); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:312678); (R-RNO-3214842)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;24679876;29212818;37084543", "class_list": "", "function": "Kdm5a expression was significantly higher in undescended testes., [RefSeq, PubMed]; LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A., [RefSeq, PubMed]; These data suggest that KDM5A is a key regulator that maintains neural progenitor cells in an undifferentiated state by repressing astrocytogenesis and that its expression is translationally controlled during astrocyte differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0032993 protein-DNA complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008584 male gonad development;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A096MJZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKI8-1", "uniprot_id": [ { "id": "D3ZKI8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKI8", "type": "external" } ], "mass": 85598.0, "length": 772, "protein_name": "Post-GPI attachment to proteins 6", "gene_name": "Pgap6", "organism": "Rat", "refseq_name": "post-GPI attachment to proteins factor 6 precursor", "refseq_ac": [ { "id": "NP_001100461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100461", "type": "external" } ], "gene_names_uniprotkb": "Pgap6; Tmem8a", "gene_names_refseq": "M83; Pgap6; Tmem8a; Tmem8", "protein_names_uniprotkb": "Post-GPI attachment to proteins 6", "protein_names_refseq": "post-GPI attachment to proteins factor 6 precursor; post-GPI attachment to proteins factor 6; post-glycosylphosphatidylinositol attachment to proteins 6; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A; type I transmembrane protein", "tax_id": 10116, "disease": "", "pathway": " (rno:303004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZKI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K2K7-1", "uniprot_id": [ { "id": "A0A0G2K2K7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K2K7", "type": "external" } ], "mass": 71630.0, "length": 627, "protein_name": "Interleukin-18 receptor accessory protein", "gene_name": "Il18rap", "organism": "Rat", "refseq_name": "interleukin-18 receptor accessory protein precursor", "refseq_ac": [ { "id": "NP_908936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908936", "type": "external" } ], "gene_names_uniprotkb": "Il18rap", "gene_names_refseq": "Il18rap", "protein_names_uniprotkb": "Interleukin-18 receptor accessory protein; Accessory protein-like; CD218 antigen-like family member B; IL-1R accessory protein-like; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta", "protein_names_refseq": "interleukin-18 receptor accessory protein precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:373540); (R-RNO-9012546)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14644029;18547159", "class_list": "", "function": "A novel splice variant of IL-18 receptor beta mRNA exists in rat brain; it encodes a putative truncated protein analogous to the soluble form of murine IL-1 receptor accessory protein and could act as an important regulator of IL-18 actions., [RefSeq, PubMed]; The aim of this study was to evaluate the constitutive expression of IL-18 and its receptors (IL-18Ralpha and IL-18Rbeta) in intestinal epithelial cells (IEC) stimulated by tumor necrosis factor-alpha and interferon-gamma., [RefSeq, PubMed]; Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0016787 hydrolase activity;GO:0042007 interleukin-18 binding;GO:0042008 interleukin-18 receptor activity", "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0071351 cellular response to interleukin-18;GO:0006954 inflammatory response;GO:0008283 cell population proliferation;GO:0070301 cellular response to hydrogen peroxide;GO:0071345 cellular response to cytokine stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2K2K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAM0-1", "uniprot_id": [ { "id": "D4AAM0_RAT", "url": "https://www.uniprot.org/uniprot/D4AAM0", "type": "external" } ], "mass": 104184.0, "length": 923, "protein_name": "Transportin-3", "gene_name": "Tnpo3", "organism": "Rat", "refseq_name": "transportin-3", "refseq_ac": [ { "id": "NP_001100057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100057", "type": "external" } ], "gene_names_uniprotkb": "Tnpo3", "gene_names_refseq": "Tnpo3", "protein_names_uniprotkb": "Transportin-3", "protein_names_refseq": "transportin-3", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 2 (Disease Ontology:DOID:0110304)", "pathway": " (rno:296954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005642 annulate lamellae;GO:0005737 cytoplasm", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAM0-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KAH3-1", "uniprot_id": [ { "id": "A0A0G2KAH3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2KAH3", "type": "external" } ], "mass": 49163.0, "length": 446, "protein_name": "T-box transcription factor TBX20", "gene_name": "Tbx20", "organism": "Rat", "refseq_name": "T-box transcription factor TBX20 isoform 1", "refseq_ac": [ { "id": "NP_001388019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388019", "type": "external" } ], "gene_names_uniprotkb": "Tbx20", "gene_names_refseq": "Tbx20", "protein_names_uniprotkb": "T-box transcription factor TBX20", "protein_names_refseq": "T-box 20; T-box transcription factor TBX20 isoform 1; T-box transcription factor TBX20", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); atrial heart septal defect 4 (Disease Ontology:DOID:0110109); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:315497)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26895318;27572266", "class_list": "", "function": "Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart., [UniProtKB, UniProtKB, UniProtKB]; Cardiac TBX20 expression showed a negative correlation with LVEF and a positive correlation with left ventricular end-systolic volume. No significant difference in TBX20 CNVs and promoter methylation was observed between IDCM patients and control group, [RefSeq, PubMed]; Silencing of TBX20 in rat myocardial and human embryonic kidney cells significantly inhibited cell proliferation, induced cell apoptosis and led to G2/M cell cycle arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0003171 atrioventricular valve development;GO:0060577 pulmonary vein morphogenesis;GO:0003175 tricuspid valve development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2KAH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8F7-1", "uniprot_id": [ { "id": "D3Z8F7_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8F7", "type": "external" } ], "mass": 59370.0, "length": 541, "protein_name": "glycerol kinase", "gene_name": "Gykl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gykl1", "gene_names_refseq": "", "protein_names_uniprotkb": "glycerol kinase; 2.7.1.30", "protein_names_refseq": "", "tax_id": 10116, "disease": "glycerol kinase deficiency (Disease Ontology:DOID:0060363)", "pathway": " (rno:291468); (R-RNO-75109)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z8F7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA78-1", "uniprot_id": [ { "id": "D3ZA78_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA78", "type": "external" } ], "mass": 85451.0, "length": 744, "protein_name": "TPX2, microtubule nucleation factor", "gene_name": "Tpx2", "organism": "Rat", "refseq_name": "targeting protein for Xklp2 isoform a", "refseq_ac": [ { "id": "NP_001101260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101260", "type": "external" } ], "gene_names_uniprotkb": "Tpx2", "gene_names_refseq": "Tpx2", "protein_names_uniprotkb": "TPX2, microtubule nucleation factor", "protein_names_refseq": "TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog; targeting protein for Xklp2 isoform a; targeting protein for Xklp2", "tax_id": 10116, "disease": "", "pathway": " (rno:311546); (R-RNO-6804756); (R-RNO-8854518)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0032147 activation of protein kinase activity;GO:0007020 microtubule nucleation;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZA78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAZ8-1", "uniprot_id": [ { "id": "D3ZAZ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAZ8", "type": "external" } ], "mass": 37966.0, "length": 316, "protein_name": "Coiled-coil domain containing 42", "gene_name": "Ccdc42", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 42", "refseq_ac": [ { "id": "NP_001100479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100479", "type": "external" } ], "gene_names_uniprotkb": "Ccdc42", "gene_names_refseq": "Ccdc42; RGD1565925", "protein_names_uniprotkb": "Coiled-coil domain containing 42", "protein_names_refseq": "coiled-coil domain-containing protein 42A; coiled-coil domain-containing protein 42", "tax_id": 10116, "disease": "", "pathway": " (rno:303234)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0002177 manchette;GO:0097228 sperm principal piece;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0001675 acrosome assembly;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCG4-1", "uniprot_id": [ { "id": "D3ZCG4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCG4", "type": "external" } ], "mass": 26021.0, "length": 227, "protein_name": "Sperm-associated antigen 7", "gene_name": "Spag7", "organism": "Rat", "refseq_name": "sperm-associated antigen 7", "refseq_ac": [ { "id": "NP_001100486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100486", "type": "external" } ], "gene_names_uniprotkb": "Spag7", "gene_names_refseq": "Spag7", "protein_names_uniprotkb": "Sperm-associated antigen 7", "protein_names_refseq": "sperm-associated antigen 7", "tax_id": 10116, "disease": "", "pathway": " (rno:303260)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZCG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCH0-1", "uniprot_id": [ { "id": "D3ZCH0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCH0", "type": "external" } ], "mass": 35448.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or9q2", "organism": "Rat", "refseq_name": "olfactory receptor Olr377", "refseq_ac": [ { "id": "NP_001001276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001276", "type": "external" } ], "gene_names_uniprotkb": "Or9q2", "gene_names_refseq": "Olr377; Or9q2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 377; olfactory receptor Olr377; olfactory receptor gene Olr377", "tax_id": 10116, "disease": "", "pathway": " (rno:293810)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCH0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEI7-1", "uniprot_id": [ { "id": "D3ZEI7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEI7", "type": "external" } ], "mass": 8053.0, "length": 71, "protein_name": "General transcription and DNA repair factor IIH subunit TFB5", "gene_name": "Gtf2h5", "organism": "Rat", "refseq_name": "general transcription factor IIH subunit 5", "refseq_ac": [ { "id": "NP_001119560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119560", "type": "external" } ], "gene_names_uniprotkb": "Gtf2h5", "gene_names_refseq": "Gtf2h5; RGD1560991", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH subunit TFB5", "protein_names_refseq": "general transcription factor IIH subunit 5; general transcription factor IIH, polypeptide 5", "tax_id": 10116, "disease": "trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 3 (Disease Ontology:DOID:0111871)", "pathway": " (rno:502227); (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075)", "pathway_count": 20, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell., [UniProtKB, UniProtKB]; In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006294 nucleotide-excision repair, preincision complex assembly;GO:0006362 transcription elongation by RNA polymerase I;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEI7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEY4-1", "uniprot_id": [ { "id": "DGKQ_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEY4", "type": "external" } ], "mass": 102545.0, "length": 937, "protein_name": "Diacylglycerol kinase theta", "gene_name": "Dgkq", "organism": "Rat", "refseq_name": "diacylglycerol kinase theta", "refseq_ac": [ { "id": "NP_001185733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185733", "type": "external" } ], "gene_names_uniprotkb": "Dgkq", "gene_names_refseq": "Dgkq", "protein_names_uniprotkb": "Diacylglycerol kinase theta; 2.7.1.107; 2.7.1.93; DAG kinase theta; DGKtheta", "protein_names_refseq": "DAG kinase theta; DGKtheta; diacylglycerol kinase theta", "tax_id": 10116, "disease": "", "pathway": " (rno:100361138); (R-RNO-114508)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15337525;22673903;9099683", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15337525). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15337525). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (PubMed:15337525). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Nuclear DGK-theta is a down-stream target of nerve growth factor signaling in PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019900 kinase binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006654 phosphatidic acid biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZEY4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFS2-1", "uniprot_id": [ { "id": "D3ZFS2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFS2", "type": "external" } ], "mass": 69601.0, "length": 612, "protein_name": "Calmegin", "gene_name": "Clgn", "organism": "Rat", "refseq_name": "calmegin isoform 2 precursor", "refseq_ac": [ { "id": "NP_001421530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421530", "type": "external" } ], "gene_names_uniprotkb": "Clgn", "gene_names_refseq": "Clgn", "protein_names_uniprotkb": "Calmegin", "protein_names_refseq": "calmegin isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;31865789", "class_list": "", "function": "Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death., [UniProtKB, UniProtKB]; Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0007338 single fertilization;GO:0006457 protein folding;GO:0036503 ERAD pathway;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZFS2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHX2-1", "uniprot_id": [ { "id": "D3ZHX2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHX2", "type": "external" } ], "mass": 33635.0, "length": 308, "protein_name": "THAP domain-containing protein 11", "gene_name": "Thap11", "organism": "Rat", "refseq_name": "THAP domain-containing protein 11", "refseq_ac": [ { "id": "NP_001100892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100892", "type": "external" } ], "gene_names_uniprotkb": "Thap11", "gene_names_refseq": "Thap11", "protein_names_uniprotkb": "THAP domain-containing protein 11", "protein_names_refseq": "THAP domain-containing protein 11", "tax_id": 10116, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (rno:307806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24677642", "class_list": "", "function": "Expansion of the polyglutamine in THAP11 forms intracellular aggregation and is toxic in PC12 cells, suggesting a putative role of THAP11 in polyglutamine disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZHX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZI68-1", "uniprot_id": [ { "id": "D3ZI68_RAT", "url": "https://www.uniprot.org/uniprot/D3ZI68", "type": "external" } ], "mass": 55416.0, "length": 499, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp31", "gene_name": "Prpf31", "organism": "Rat", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp31", "refseq_ac": [ { "id": "NP_001099689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099689", "type": "external" } ], "gene_names_uniprotkb": "Prpf31", "gene_names_refseq": "Prpf31", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; U4/U6 snRNP 61 kDa protein", "protein_names_refseq": "PRP31 pre-mRNA processing factor 31 homolog; U4/U6 small nuclear ribonucleoprotein Prp31", "tax_id": 10116, "disease": "retinitis pigmentosa 11 (Disease Ontology:DOID:0110408); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:292536)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding;GO:0030622 U4atac snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0071166 ribonucleoprotein complex localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZI68-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZII6-1", "uniprot_id": [ { "id": "D3ZII6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZII6", "type": "external" } ], "mass": 34468.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or4f56", "organism": "Rat", "refseq_name": "olfactory receptor Olr778", "refseq_ac": [ { "id": "NP_001000607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000607", "type": "external" } ], "gene_names_uniprotkb": "Or4f56", "gene_names_refseq": "Olr778; Or4f56", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 778; olfactory receptor Olr778; olfactory receptor gene Olr778", "tax_id": 10116, "disease": "", "pathway": " (rno:404796)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZRJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZS29-1", "uniprot_id": [ { "id": "D3ZS29_RAT", "url": "https://www.uniprot.org/uniprot/D3ZS29", "type": "external" } ], "mass": 35163.0, "length": 312, "protein_name": "Homeobox protein NANOG", "gene_name": "Nanog", "organism": "Rat", "refseq_name": "homeobox protein NANOG", "refseq_ac": [ { "id": "NP_001094251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094251", "type": "external" } ], "gene_names_uniprotkb": "Nanog", "gene_names_refseq": "Nanog", "protein_names_uniprotkb": "Homeobox protein NANOG; Homeobox transcription factor Nanog", "protein_names_refseq": "homeobox protein NANOG", "tax_id": 10116, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (rno:414065)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0009825 multidimensional cell growth;GO:2000648 positive regulation of stem cell proliferation;GO:0001714 endodermal cell fate specification;GO:0072752 cellular response to rapamycin;GO:0001710 mesodermal cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZS29-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTW1-1", "uniprot_id": [ { "id": "D3ZTW1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTW1", "type": "external" } ], "mass": 107364.0, "length": 1006, "protein_name": "Integrator complex subunit 5", "gene_name": "Ints5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ints5", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrator complex subunit 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:309200); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTW1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTY5-1", "uniprot_id": [ { "id": "D3ZTY5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTY5", "type": "external" } ], "mass": 51559.0, "length": 461, "protein_name": "USH1 protein network component sans", "gene_name": "Ush1g", "organism": "Rat", "refseq_name": "pre-mRNA splicing regulator USH1G", "refseq_ac": [ { "id": "NP_001099320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099320", "type": "external" } ], "gene_names_uniprotkb": "Ush1g", "gene_names_refseq": "Ush1g", "protein_names_uniprotkb": "USH1 protein network component sans", "protein_names_refseq": "Usher syndrome 1G (autosomal recessive); Usher syndrome 1G homolog; pre-mRNA splicing regulator USH1G", "tax_id": 10116, "disease": "Usher syndrome type 1G (Disease Ontology:DOID:0110834)", "pathway": " (rno:287819)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016607 nuclear speck", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0045494 photoreceptor cell maintenance;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0007605 sensory perception of sound;GO:0060113 inner ear receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTY5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU10-1", "uniprot_id": [ { "id": "D3ZU10_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU10", "type": "external" } ], "mass": 54563.0, "length": 516, "protein_name": "Solute carrier family 49 member 3", "gene_name": "Slc49a3", "organism": "Rat", "refseq_name": "solute carrier family 49 member A3", "refseq_ac": [ { "id": "NP_001100716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100716", "type": "external" } ], "gene_names_uniprotkb": "Slc49a3; Mfsd7", "gene_names_refseq": "Mfsd7; RGD1304688; Slc49a3", "protein_names_uniprotkb": "Solute carrier family 49 member 3", "protein_names_refseq": "major facilitator superfamily domain containing 7; major facilitator superfamily domain-containing protein 7; solute carrier family 49 member A3", "tax_id": 10116, "disease": "", "pathway": " (rno:305625)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZU10-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU82-1", "uniprot_id": [ { "id": "D3ZU82_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU82", "type": "external" } ], "mass": 63399.0, "length": 581, "protein_name": "Membrane frizzled-related protein", "gene_name": "Mfrp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mfrp", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane frizzled-related protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "isolated microphthalmia 5 (Disease Ontology:DOID:0060837); late-onset retinal degeneration (Disease Ontology:DOID:0060869); nanophthalmos (Disease Ontology:DOID:0080634); retinitis pigmentosa (Disease Ontology:DOID:10584); microphthalmia (Disease Ontology:DOID:10629); fundus albipunctatus (Disease Ontology:DOID:11105)", "pathway": " (rno:315597)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZU82-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUX7-1", "uniprot_id": [ { "id": "D3ZUX7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUX7", "type": "external" } ], "mass": 74549.0, "length": 666, "protein_name": "Malonate--CoA ligase ACSF3, mitochondrial", "gene_name": "Acsf3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Acsf3", "gene_names_refseq": "", "protein_names_uniprotkb": "Malonate--CoA ligase ACSF3, mitochondrial; 6.2.1.76; Acyl-CoA synthetase family member 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined malonic and methylmalonic acidemia (Disease Ontology:DOID:0111263)", "pathway": " (R-RNO-75876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0016405 CoA-ligase activity;GO:0090409 malonyl-CoA synthetase activity", "go_cellular_component": "GO:0005739 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0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035728 response to hepatocyte growth factor;GO:0008283 cell population proliferation;GO:0045184 establishment of protein localization;GO:0023052 signaling;GO:0048012 hepatocyte growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVA1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVI0-1", "uniprot_id": [ { "id": "D3ZVI0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVI0", "type": "external" } ], "mass": 26798.0, "length": 250, "protein_name": "Fibroblast growth factor binding protein 3", "gene_name": "Fgfbp3", "organism": "Rat", "refseq_name": "fibroblast growth factor-binding protein 3 precursor", 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RGD1307724", "protein_names_uniprotkb": "Dermatan sulfate epimerase-like", "protein_names_refseq": "dermatan-sulfate epimerase-like protein precursor; dermatan-sulfate epimerase-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:297865); (R-RNO-2022923)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0047757 chondroitin-glucuronate 5-epimerase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0050654 chondroitin sulfate proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYE3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYT9-1", "uniprot_id": [ { "id": "D3ZYT9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYT9", "type": "external" } ], "mass": 41252.0, "length": 374, "protein_name": "F-box/LRR-repeat protein 8", "gene_name": "Fbxl8", "organism": "Rat", "refseq_name": "F-box/LRR-repeat protein 8", "refseq_ac": [ { "id": "NP_001383381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383381", "type": "external" } ], "gene_names_uniprotkb": "Fbxl8", "gene_names_refseq": "Fbxl8; 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Tecrl", "protein_names_uniprotkb": "Trans-2,3-enoyl-CoA reductase-like; Steroid 5-alpha-reductase 2-like 2 protein", "protein_names_refseq": "steroid 5 alpha-reductase 2-like 2; trans-2,3-enoyl-CoA reductase-like", "tax_id": 10116, "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); catecholaminergic polymorphic ventricular tachycardia 3 (Disease Ontology:DOID:0060677)", "pathway": " (rno:364134); (R-RNO-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A1Y9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A217-1", "uniprot_id": [ { "id": "D4A217_RAT", "url": "https://www.uniprot.org/uniprot/D4A217", "type": "external" } ], "mass": 37533.0, "length": 328, "protein_name": "G protein-coupled receptor 82", "gene_name": "Gpr82", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 82", "refseq_ac": [ { "id": "NP_001388147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388147", "type": "external" } ], "gene_names_uniprotkb": "Gpr82", "gene_names_refseq": "Gpr82", "protein_names_uniprotkb": "G protein-coupled receptor 82", "protein_names_refseq": "probable G-protein coupled receptor 82; rCG42826-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100362441)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31266033;32583711", "class_list": "", "function": "Modifications in GPR21 and GPR82 genes expression as a consequence of metabolic syndrome etiology., [RefSeq, PubMed]; Silencing of GPR82 with Interference RNA Improved Metabolic Profiles in Rats with High Fructose Intake., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0060612 adipose tissue development;GO:0032094 response to food;GO:0097009 energy homeostasis;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A217-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A259-1", "uniprot_id": [ { "id": "D4A259_RAT", "url": "https://www.uniprot.org/uniprot/D4A259", "type": "external" } ], "mass": 16311.0, "length": 142, "protein_name": "DNA-directed RNA polymerase II subunit RPB4", "gene_name": "Polr2d", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase II subunit RPB4", "refseq_ac": [ { "id": "NP_001102356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102356", "type": "external" } ], "gene_names_uniprotkb": "Polr2d", "gene_names_refseq": "Polr2d", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB4; DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II subunit rpb4", "protein_names_refseq": "DNA-directed RNA polymerase II subunit RPB4; polymerase (RNA) II (DNA directed) polypeptide D; polymerase (RNA) II subunit D", "tax_id": 10116, "disease": "", "pathway": " (rno:364834)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2D/RPB4 is part of a subcomplex with POLR2G/RPB7 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005665 RNA polymerase II, core complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A259-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2D4-1", "uniprot_id": [ { "id": "D4A2D4_RAT", "url": "https://www.uniprot.org/uniprot/D4A2D4", "type": "external" } ], "mass": 49685.0, "length": 440, "protein_name": "Chitinase acidic-like 1", "gene_name": "Chial1", "organism": "Rat", "refseq_name": "chitinase acidic-like 1 isoform 1", "refseq_ac": [ { "id": "NP_001426353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426353", "type": "external" } ], "gene_names_uniprotkb": "Chial1; RGD1309110", "gene_names_refseq": "Chial1; Chil8; RGD1309110", "protein_names_uniprotkb": "Chitinase acidic-like 1", "protein_names_refseq": "Acidic mammalian chitinase-like; chitinase acidic-like 1 isoform 1", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); neuromyelitis optica (Disease Ontology:DOID:8869)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2D4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2E7-1", "uniprot_id": [ { "id": "D4A2E7_RAT", "url": "https://www.uniprot.org/uniprot/D4A2E7", "type": "external" } ], "mass": 134851.0, "length": 1211, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif, 19", "gene_name": "Adamts19", "organism": "Rat", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor", "refseq_ac": [ { "id": "NP_001101903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101903", "type": "external" } ], "gene_names_uniprotkb": "Adamts19", "gene_names_refseq": "Adamts19", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif, 19", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 19 precursor; A disintegrin and metalloproteinase with thrombospondin motifs 19; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); aortic valve disease (Disease Ontology:DOID:62)", "pathway": " (rno:361332); (R-RNO-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0003183 mitral valve morphogenesis;GO:0060412 ventricular septum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2E7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2F0-1", "uniprot_id": [ { "id": "D4A2F0_RAT", "url": "https://www.uniprot.org/uniprot/D4A2F0", "type": "external" } ], "mass": 35470.0, "length": 326, "protein_name": "G protein subunit beta 1 like", "gene_name": "Gnb1l", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit beta-like protein 1", "refseq_ac": [ { "id": "NP_001385806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385806", "type": "external" } ], "gene_names_uniprotkb": "Gnb1l", "gene_names_refseq": "Gnb1l", "protein_names_uniprotkb": "G protein subunit beta 1 like", "protein_names_refseq": "guanine nucleotide binding protein (G protein), beta polypeptide 1-like; guanine nucleotide-binding protein subunit beta-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:680266)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0R4I1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0035176 social behavior;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2F0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A411-1", "uniprot_id": [ { "id": "D4A411_RAT", "url": "https://www.uniprot.org/uniprot/D4A411", "type": "external" } ], "mass": 137296.0, "length": 1212, "protein_name": "Bromodomain and PHD finger containing, 1", "gene_name": "Brpf1", "organism": "Rat", "refseq_name": "peregrin isoform 2", "refseq_ac": [ { "id": "NP_001402863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402863", "type": "external" } ], "gene_names_uniprotkb": "Brpf1", "gene_names_refseq": "Brpf1", "protein_names_uniprotkb": "Bromodomain and PHD finger containing, 1", "protein_names_refseq": "peregrin isoform 2; peregrin", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (R-RNO-3214847); (R-RNO-6804758)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000123 histone acetyltransferase complex", "go_biological_process": "GO:0001570 vasculogenesis;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A411-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4S5-1", "uniprot_id": [ { "id": "D4A4S5_RAT", "url": "https://www.uniprot.org/uniprot/D4A4S5", "type": "external" } ], "mass": 29169.0, "length": 252, "protein_name": "Folate receptor beta", "gene_name": "Folr2", "organism": "Rat", "refseq_name": "folate receptor beta precursor", "refseq_ac": [ { "id": "NP_001425256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001425256", "type": "external" } ], "gene_names_uniprotkb": "Folr2", "gene_names_refseq": "Folr2", "protein_names_uniprotkb": "Folate receptor beta", "protein_names_refseq": "folate receptor 2 (fetal); folate receptor beta precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:293154); (R-RNO-163125); (R-RNO-196757); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "26181632", "class_list": "", "function": "EC0565 forms micellar aggregates in physiological buffers and demonstrates good water solubility as well as strong multivalent FR-binding capacity. EC0565 inhibited mTOR signaling in rat macrophages at nanomolar concentrations Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005542 folic acid binding;GO:0061714 folic acid receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4S5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A532-1", "uniprot_id": [ { "id": "D4A532_RAT", "url": "https://www.uniprot.org/uniprot/D4A532", "type": "external" } ], "mass": 27905.0, "length": 253, "protein_name": "Homeobox protein MOX-1", "gene_name": "Meox1", "organism": "Rat", "refseq_name": "homeobox protein MOX-1", "refseq_ac": [ { "id": "NP_001102307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102307", "type": "external" } ], "gene_names_uniprotkb": "Meox1", "gene_names_refseq": "Meox1", "protein_names_uniprotkb": "Homeobox protein MOX-1; Mesenchyme homeobox 1", "protein_names_refseq": "homeobox protein MOX-1", "tax_id": 10116, "disease": "Klippel-Feil syndrome 2 (Disease Ontology:DOID:0080590); Klippel-Feil syndrome (Disease Ontology:DOID:10426)", "pathway": " (rno:363684)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29113690;34233723", "class_list": "", "function": "Meox1 promotes vascular smooth muscle cell phenotypic modulation., [RefSeq, PubMed]; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome., [UniProtKB, UniProtKB]; Spatio-temporal model of Meox1 expression control involvement of Sca-1-positive stem cells in neointima formation through the synergistic effect of Rho/CDC42 and SDF-1alpha/CXCR4. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001757 somite specification;GO:0061053 somite development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A532-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6K0-1", "uniprot_id": [ { "id": "D4A6K0_RAT", "url": "https://www.uniprot.org/uniprot/D4A6K0", "type": "external" } ], "mass": 15657.0, "length": 142, "protein_name": "SCAN domain-containing protein 1", "gene_name": "Scand1", "organism": "Rat", "refseq_name": "SCAN domain-containing protein 1", "refseq_ac": [ { "id": "NP_001102069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102069", "type": "external" } ], "gene_names_uniprotkb": "Scand1", "gene_names_refseq": "Scand1", "protein_names_uniprotkb": "SCAN domain-containing protein 1", "protein_names_refseq": "SCAN domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362252)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate transcriptional activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6K0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A704-1", "uniprot_id": [ { "id": "D4A704_RAT", "url": "https://www.uniprot.org/uniprot/D4A704", "type": "external" } ], "mass": 46818.0, "length": 421, "protein_name": "Zinc finger protein 641", "gene_name": "Zfp641", "organism": "Rat", "refseq_name": "zinc finger protein 641", "refseq_ac": [ { "id": "NP_001100262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100262", "type": "external" } ], "gene_names_uniprotkb": "Zfp641", "gene_names_refseq": "RGD1310412; Zfp641; Znf641", "protein_names_uniprotkb": "Zinc finger protein 641", "protein_names_refseq": "zinc finger protein 641", "tax_id": 10116, "disease": "", "pathway": " (rno:300197); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. Activates transcriptional activities of SRE and AP-1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A704-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7D7-1", "uniprot_id": [ { "id": "D4A7D7_RAT", "url": "https://www.uniprot.org/uniprot/D4A7D7", "type": "external" } ], "mass": 89840.0, "length": 797, "protein_name": "GDH/6PGL endoplasmic bifunctional protein", "gene_name": "H6pd", "organism": "Rat", "refseq_name": "GDH/6PGL endoplasmic bifunctional protein precursor", "refseq_ac": [ { "id": "NP_001100168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100168", "type": "external" } ], "gene_names_uniprotkb": "H6pd", "gene_names_refseq": "H6pdh; H6pd", "protein_names_uniprotkb": "GDH/6PGL endoplasmic bifunctional protein; 1.1.1.363; 1.1.1.47; 3.1.1.31", "protein_names_refseq": "GDH/6PGL endoplasmic bifunctional protein precursor; GDH/6PGL endoplasmic bifunctional protein", "tax_id": 10116, "disease": "cortisone reductase deficiency (Disease Ontology:DOID:0090139); cortisone reductase deficiency 1 (Disease Ontology:DOID:0090141); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (rno:298655)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16337333;21163329;21620971;29393594", "class_list": "", "function": "Activation of expression and activity of Hexose-6-phosphate dehydrogenase in primary hepatocytes was mediated through levels of glucose, not related to insulin levels so concluding that glucose instead of insulin directly regulates H6PDH., [RefSeq, PubMed]; It was found that H6PD was present in all investigated tissues; both expression and activity remained within an order of magnitude. Correlation was found between the dehydrogenase activity and protein or mRNA levels., [RefSeq, PubMed]; The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11betaHSD1 and H6PDH based on their co-localization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.31", "type": "external" }, { "id": "1.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.47", "type": "external" }, { "id": "1.1.1.363", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.363", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.49", "type": "external" } ], "go_molecular_function": "GO:0017057 6-phosphogluconolactonase activity;GO:0030246 carbohydrate binding;GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0047936 glucose 1-dehydrogenase [NAD(P)+] activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0097305 response to alcohol;GO:0031667 response to nutrient levels;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A7D7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7F1-1", "uniprot_id": [ { "id": "D4A7F1_RAT", "url": "https://www.uniprot.org/uniprot/D4A7F1", "type": "external" } ], "mass": 30200.0, "length": 281, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Rnf186", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF186", "refseq_ac": [ { "id": "NP_001103062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103062", "type": "external" } ], "gene_names_uniprotkb": "Rnf186", "gene_names_refseq": "Rnf186", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF186", "tax_id": 10116, "disease": "", "pathway": " (rno:690433)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7F1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A820-1", "uniprot_id": [ { "id": "D4A820_RAT", "url": "https://www.uniprot.org/uniprot/D4A820", "type": "external" } ], "mass": 55548.0, "length": 499, "protein_name": "Cytochrome P450", "gene_name": "Cyp2s1", "organism": "Rat", "refseq_name": "cytochrome P450, family 2, subfamily s, polypeptide 1 precursor", "refseq_ac": [ { "id": "NP_001100965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100965", "type": "external" } ], "gene_names_uniprotkb": "Cyp2s1", "gene_names_refseq": "Cyp2s1", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.1", "protein_names_refseq": "cytochrome P450 2S1; cytochrome P450, family 2, subfamily s, polypeptide 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:308445); (R-RNO-211958); (R-RNO-211981); (R-RNO-211999)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19883719", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases., [UniProtKB, UniProtKB]; Regulated by aryl hydrocarbon receptor agonists when in the presence of 3-methylcholanthrene or 2,3,7,8-tetrachlorodibenzo-p-dioxin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016836 hydro-lyase activity;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A820-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9I7-1", "uniprot_id": [ { "id": "D4A9I7_RAT", "url": "https://www.uniprot.org/uniprot/D4A9I7", "type": "external" } ], "mass": 29261.0, "length": 259, "protein_name": "Leucine rich repeat containing 3B", "gene_name": "Lrrc3b", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 3B precursor", "refseq_ac": [ { "id": "NP_001386424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386424", "type": "external" } ], "gene_names_uniprotkb": "Lrrc3b", "gene_names_refseq": "Lrrc3b; RGD1311897", "protein_names_uniprotkb": "Leucine rich repeat containing 3B", "protein_names_refseq": "leucine-rich repeat-containing protein 3B precursor; leucine-rich repeat-containing protein 3B", "tax_id": 10116, "disease": "", "pathway": " (rno:305705)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20080187", "class_list": "", "function": "Lrrc3b gene expression in olfactory receptor neurons was regulated more than 10-fold by odorant activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A9I7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9J2-1", "uniprot_id": [ { "id": "D4A9J2_RAT", "url": "https://www.uniprot.org/uniprot/D4A9J2", "type": "external" } ], "mass": 41069.0, "length": 370, "protein_name": "Protein Wnt", "gene_name": "Wnt1", "organism": "Rat", "refseq_name": "proto-oncogene Wnt-1 precursor", "refseq_ac": [ { "id": "NP_001099184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099184", "type": "external" } ], "gene_names_uniprotkb": "Wnt1", "gene_names_refseq": "Int1; Wnt1", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "Wingless-type MMTV integration site 1, homolog; proto-oncogene Wnt-1 precursor; proto-oncogene Wnt-1; wingless-related MMTV integration site 1; wingless-type MMTV integration site family, member 1", "tax_id": 10116, "disease": "osteogenesis imperfecta type 15 (Disease Ontology:DOID:0110347); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24881); (R-RNO-201681); (R-RNO-3238698); (R-RNO-4086400); (R-RNO-4641262)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "29152652;31356809;31886199;37658228", "class_list": "", "function": "A novel mutation in intron 1 of Wnt1 causes developmental loss of dopaminergic neurons in midbrain and ASD-like behaviors in rats., [RefSeq, PubMed]; Combined exposure to Paraquat and maneb during development decreased mRNA and protein expression of Wnt1, TH and Nurr1 and increased expression of Wnt5a in the offspring., [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Melatonin can attenuate beta-GP-induced VSMC calcification through the suppression of Wnt1/beta-catenin system. Publication Status: Online-Only, [RefSeq, PubMed]; This work reveals the ANKH regulation of Wnt1 in vascular smooth muscle cells is essential for blocking vascular calcification (VC). Our findings may contribute to the development of medications that target Wnt signaling and/or ANKH to inhibit VC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0021551 central nervous system morphogenesis;GO:0022037 metencephalon development;GO:0021536 diencephalon development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A9J2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACM6-1", "uniprot_id": [ { "id": "D4ACM6_RAT", "url": "https://www.uniprot.org/uniprot/D4ACM6", "type": "external" } ], "mass": 54799.0, "length": 486, "protein_name": "Programmed cell death 7", "gene_name": "Pdcd7", "organism": "Rat", "refseq_name": "programmed cell death protein 7", "refseq_ac": [ { "id": "NP_001382573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382573", "type": "external" } ], "gene_names_uniprotkb": "Pdcd7", "gene_names_refseq": "Pdcd7", "protein_names_uniprotkb": "Programmed cell death 7", "protein_names_refseq": "programmed cell death protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:363082); (R-RNO-72165)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005689 U12-type spliceosomal complex;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0089701 U2AF complex;GO:0071016 U12-type precatalytic spliceosome", "go_biological_process": "GO:2001235 positive regulation of apoptotic signaling pathway;GO:0051384 response to glucocorticoid;GO:0008380 RNA splicing;GO:0070234 positive regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACV2-1", "uniprot_id": [ { "id": "D4ACV2_RAT", "url": "https://www.uniprot.org/uniprot/D4ACV2", "type": "external" } ], "mass": 34954.0, "length": 317, "protein_name": "Olfactory receptor family 52 subfamily M member 1", "gene_name": "Or52m1", "organism": "Rat", "refseq_name": "olfactory receptor Olr48", "refseq_ac": [ { "id": "NP_001000122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000122", "type": "external" } ], "gene_names_uniprotkb": "Or52m1", "gene_names_refseq": "Olr48; Or52m1", "protein_names_uniprotkb": "Olfactory receptor family 52 subfamily M member 1", "protein_names_refseq": "olfactory receptor 48; olfactory receptor Olr48; olfactory receptor gene Olr48", "tax_id": 10116, "disease": "", "pathway": " (rno:293188)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. 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Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0106432 queuosine nucleosidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006400 tRNA modification;GO:0043174 nucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7FM32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7K4-1", "uniprot_id": [ { "id": "G3V7K4_RAT", "url": "https://www.uniprot.org/uniprot/G3V7K4", "type": "external" } ], "mass": 23746.0, "length": 205, "protein_name": "Gap junction epsilon-1 protein", "gene_name": "Gje1", "organism": "Rat", "refseq_name": "putative gap junction epsilon-1 protein", "refseq_ac": [ { "id": "NP_001184021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184021", "type": "external" } ], "gene_names_uniprotkb": "Gje1", "gene_names_refseq": "Cxnt; 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Transcription initiation factor IIE subunit alpha", "protein_names_refseq": "general transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1 (alpha subunit); general transcription factor IIE, polypeptide 1, alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:303918); (R-RNO-674695); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005673 transcription factor TFIIE complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V992-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R659-1", "uniprot_id": [ { "id": "M0R659_RAT", "url": "https://www.uniprot.org/uniprot/M0R659", "type": "external" } ], "mass": 37438.0, "length": 327, "protein_name": "Olfactory receptor", "gene_name": "Or5m8", "organism": "Rat", "refseq_name": "olfactory receptor Olr472", "refseq_ac": [ { "id": "NP_001000301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000301", "type": "external" } ], "gene_names_uniprotkb": "Or5m8", "gene_names_refseq": "Olr472; Or5m8; ratchr3-69100954-69101937_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 472; olfactory receptor Olr472; olfactory receptor gene Olr472", "tax_id": 10116, "disease": "", "pathway": " (rno:295743)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R659-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R8U7-1", "uniprot_id": [ { "id": "M0R8U7_RAT", "url": "https://www.uniprot.org/uniprot/M0R8U7", "type": "external" } ], "mass": 45286.0, "length": 379, "protein_name": "Spermatogenesis associated 17", "gene_name": "Spata17", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spata17", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatogenesis associated 17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R8U7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R9Q1-1", "uniprot_id": [ { "id": "M0R9Q1_RAT", "url": "https://www.uniprot.org/uniprot/M0R9Q1", "type": "external" } ], "mass": 69494.0, "length": 669, "protein_name": "RNA-binding protein 14", "gene_name": "Rbm14", "organism": "Rat", "refseq_name": "RNA-binding protein 14", "refseq_ac": [ { "id": "NP_596879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596879", "type": "external" } ], "gene_names_uniprotkb": "Rbm14; Rbm4", "gene_names_refseq": "CoAA; Rbm14", "protein_names_uniprotkb": "RNA-binding protein 14; RNA-binding motif protein 14", "protein_names_refseq": "RNA-binding protein 14; coactivator activator", "tax_id": 10116, "disease": "", "pathway": " (rno:170900); (rno:293663)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19585539;22673903;26306672", "class_list": "", "function": "CoAA binds Runx2 and prevents Runx2 binding to DNA, [RefSeq, PubMed]; This study idnetifed that the RBM14 as inhibitors of neurite outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:1990935 splicing factor binding;GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0002218 activation of innate immune response;GO:0007369 gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0R9Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RC65-1", "uniprot_id": [ { "id": "M0RC65_RAT", "url": "https://www.uniprot.org/uniprot/M0RC65", "type": "external" } ], "mass": 18710.0, "length": 166, "protein_name": "Cofilin 2", "gene_name": "Cfl2", "organism": "Rat", "refseq_name": "cofilin-2", "refseq_ac": [ { "id": "NP_001102452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102452", "type": "external" } ], "gene_names_uniprotkb": "Cfl2", "gene_names_refseq": "Cfl2", "protein_names_uniprotkb": "Cofilin 2", "protein_names_refseq": "cofilin 2, muscle; cofilin-2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); nemaline myopathy 7 (Disease Ontology:DOID:0110934); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:366624)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19023180;22673903;25373779;31400829", "class_list": "", "function": "Actin depolymerizing factor (ADF)/cofilin controls actin turnover to sustain axon regeneration after spinal cord injury through its actin-severing activity. This pinpoints ADF/cofilin as a key regulator of axon growth competence, irrespective of developmental stage., [RefSeq, PubMed]; Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells., [RefSeq, PubMed]; Cofilin-2 evolved specific biochemical and cellular properties that allow it to control actin dynamics in sarcomeres, where filament pointed ends may contain a mixture of ADP- and ATP/ADP-Pi-actin subunits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0031674 I band;GO:0030018 Z disc", "go_biological_process": "GO:0007015 actin filament organization;GO:0046716 muscle cell cellular homeostasis;GO:0045214 sarcomere organization;GO:0051014 actin filament severing;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "M0RC65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XII4-1", "uniprot_id": [ { "id": "Q5XII4_RAT", "url": "https://www.uniprot.org/uniprot/Q5XII4", "type": "external" } ], "mass": 24773.0, "length": 219, "protein_name": "SLX9 ribosome biogenesis factor", "gene_name": "Slx9", "organism": "Rat", "refseq_name": "ribosome biogenesis protein SLX9 homolog", "refseq_ac": [ { "id": "NP_001008308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008308", "type": "external" } ], "gene_names_uniprotkb": "Slx9; Fam207a", "gene_names_refseq": "Fam207a; RGD1311257; Slx9", "protein_names_uniprotkb": "SLX9 ribosome biogenesis factor", "protein_names_refseq": "family with sequence similarity 207, member A; ribosome biogenesis protein SLX9 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:294333)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XII4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXI7-1", "uniprot_id": [ { "id": "Q6TXI7_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXI7", "type": "external" } ], "mass": 68877.0, "length": 615, "protein_name": "Uncharacterized LOC134486093", "gene_name": "LOC134486093", "organism": "Rat", "refseq_name": "uncharacterized protein LOC134486093", "refseq_ac": [ { "id": "XP_063140944", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063140944", "type": "external" } ], "gene_names_uniprotkb": "LOC134486093", "gene_names_refseq": "LOC134486093", "protein_names_uniprotkb": "Uncharacterized LOC134486093", "protein_names_refseq": "uncharacterized protein LOC134486093", "tax_id": 10116, "disease": "", "pathway": " (rno:134486093)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006275 regulation of DNA replication;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TXI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54814-1", "uniprot_id": [ { "id": "CCR3_RAT", "url": "https://www.uniprot.org/uniprot/O54814", "type": "external" } ], "mass": 41643.0, "length": 359, "protein_name": "C-C chemokine receptor type 3", "gene_name": "Ccr3", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 3", "refseq_ac": [ { "id": "NP_446410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446410", "type": "external" } ], "gene_names_uniprotkb": "Ccr3; Cmkbr3", "gene_names_refseq": "Ccr3; Cmkbr3", "protein_names_uniprotkb": "C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3", "protein_names_refseq": "C-C CKR-3; C-C chemokine receptor type 3; CC-CKR-3; CCR-3; CKR3; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 3", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); hepatitis B (Disease Ontology:DOID:2043); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); rhinitis (Disease Ontology:DOID:4483); periapical granuloma (Disease Ontology:DOID:4617); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:117027); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "28279120;29393594;31151084;34795678;9655467", "class_list": "", "function": "Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain. Publication Status: Online-Only, [RefSeq, PubMed]; CCR3 levels in EAE rats were significantly increased. CCR3 levels in brain tissues were positively correlated with the inflammatory scores., [RefSeq, PubMed]; G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. May also act as a possible functional receptor for NARS1., [UniProtKB, UniProtKB]; Our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55169", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54814-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHS6-1", "uniprot_id": [ { "id": "BAP1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHS6", "type": "external" } ], "mass": 80310.0, "length": 727, "protein_name": "Ubiquitin carboxyl-terminal hydrolase BAP1", "gene_name": "Bap1", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase BAP1 isoform 4", "refseq_ac": [ { "id": "NP_001100762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100762", "type": "external" } ], "gene_names_uniprotkb": "Bap1", "gene_names_refseq": "Bap1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase BAP1; 3.4.19.12; BRCA1-associated protein 1", "protein_names_refseq": "BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Brca1 associated protein 1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform 4; ubiquitin carboxyl-terminal hydrolase BAP1", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); basal cell carcinoma (Disease Ontology:DOID:2513); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); uveal melanoma (Disease Ontology:DOID:6039); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (rno:306257); (R-RNO-5689603); (R-RNO-5693565)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;29393594;38816686;38906226", "class_list": "", "function": "Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor. Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization., [UniProtKB, UniProtKB]; MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031490 chromatin DNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0030223 neutrophil differentiation;GO:0043249 erythrocyte maturation;GO:0000278 mitotic cell cycle;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZHS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQE1-1", "uniprot_id": [ { "id": "CEA16_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQE1", "type": "external" } ], "mass": 45904.0, "length": 423, "protein_name": "Cell adhesion molecule CEACAM16", "gene_name": "Ceacam16", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ceacam16", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM16; CEA cell adhesion molecule 16; Carcinoembryonic antigen-related cell adhesion molecule 16", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 4A (Disease Ontology:DOID:0110573); autosomal dominant nonsyndromic deafness 4B (Disease Ontology:DOID:0110574); autosomal recessive nonsyndromic deafness 113 (Disease Ontology:DOID:0111636)", "pathway": " (rno:292700)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032426 stereocilium tip", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQE1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8K2-1", "uniprot_id": [ { "id": "CCD39_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8K2", "type": "external" } ], "mass": 109555.0, "length": 934, "protein_name": "Coiled-coil domain-containing protein 39", "gene_name": "Ccdc39", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 39", "refseq_ac": [ { "id": "NP_001401969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401969", "type": "external" } ], "gene_names_uniprotkb": "Ccdc39", "gene_names_refseq": "Ccdc39; RGD1306277", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 39", "protein_names_refseq": "coiled-coil domain containing 39; coiled-coil domain-containing protein 39", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 14 (Disease Ontology:DOID:0110598); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:310315)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31771992", "class_list": "", "function": "In Ccdc39(prh/prh) mutant rats demonstrate a possible causal role of neuroinflammation in neonatal hydrocephalus development, which involves impaired cortical development and glymphatic CSF flow. Publication Status: Online-Only, [RefSeq, PubMed]; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A2M2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007399 nervous system development;GO:0007507 heart development;GO:0022010 central nervous system myelination;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8K2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08764-1", "uniprot_id": [ { "id": "ABTB2_RAT", "url": "https://www.uniprot.org/uniprot/O08764", "type": "external" } ], "mass": 111603.0, "length": 1009, "protein_name": "Ankyrin repeat and BTB/POZ domain-containing protein 2", "gene_name": "Abtb2", "organism": "Rat", "refseq_name": "ankyrin repeat and BTB/POZ domain-containing protein 2", "refseq_ac": [ { "id": "NP_599230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599230", "type": "external" } ], "gene_names_uniprotkb": "Abtb2; Cca3", "gene_names_refseq": "Abtb2; Cca3", "protein_names_uniprotkb": "Ankyrin repeat and BTB/POZ domain-containing protein 2; CCA3; Confluent 3Y1 cell-associated protein", "protein_names_refseq": "ankyrin repeat and BTB (POZ) domain containing 2; ankyrin repeat and BTB/POZ domain-containing protein 2; confluent 3Y1 cell-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171440)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;9109406", "class_list": "", "function": "May be involved in the initiation of hepatocyte growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0097237 cellular response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08764-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70594-1", "uniprot_id": [ { "id": "S22A5_RAT", "url": "https://www.uniprot.org/uniprot/O70594", "type": "external" } ], "mass": 62567.0, "length": 557, "protein_name": "Organic cation/carnitine transporter 2", "gene_name": "Slc22a21; Slc22a5", "organism": "Rat", "refseq_name": "organic cation/carnitine transporter 2", "refseq_ac": [ { "id": "NP_062142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062142", "type": "external" } ], "gene_names_uniprotkb": "Slc22a21; Slc22a5; LOC303140; Octn2", "gene_names_refseq": "CT1; OCTN2; Slc22a5; UST2r", "protein_names_uniprotkb": "Organic cation/carnitine transporter 2; CT1; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5; UST2r", "protein_names_refseq": "high-affinity carnitine transporter; high-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; organic cation/carnitine transporter 2; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); scapuloperoneal myopathy (Disease Ontology:DOID:0060253); X-linked Emery-Dreifuss muscular dystrophy 6 (Disease Ontology:DOID:0070251); reducing body myopathy 1A (Disease Ontology:DOID:0080090); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); reducing body myopathy 1B (Disease Ontology:DOID:0080687); Uruguay faciocardiomusculoskeletal syndrome (Disease Ontology:DOID:0112148); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); systemic primary carnitine deficiency disease (Disease Ontology:DOID:14365); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); myopathy (Disease Ontology:DOID:423); congestive heart failure (Disease Ontology:DOID:6000); inherited metabolic disorder (Disease Ontology:DOID:655); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:29726); (rno:303140); (R-RNO-200425); (R-RNO-549127)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10454528;17616214;22673903;24349196;28666211;9541011;9792817", "class_list": "", "function": "OCTN2 plays a positive role in epididymal epithelial cells, and might be useful in the clinical treatment of male infertility by serving as a key regulatory factor. Erratum:[Biomed Pharmacother. 2018 Aug;104:854. doi: 10.1016/j.biopha.2018.04.029. PMID: 29753602], [RefSeq, PubMed]; PKC activation resulted in an augmented Octn2 presence in cholesterol/sphingolipid-rich microdomains of plasma membrane (rafts) and increased co-precipitation of Octn2 with raft-proteins, caveolin-1 and flotillin-1. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWL0", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0007626 locomotory behavior;GO:0034612 response to tumor necrosis factor;GO:0007005 mitochondrion organization;GO:0007512 adult heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70594-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70467-1", "uniprot_id": [ { "id": "ANM3_RAT", "url": "https://www.uniprot.org/uniprot/O70467", "type": "external" } ], "mass": 59420.0, "length": 528, "protein_name": "Protein arginine N-methyltransferase 3", "gene_name": "Prmt3", "organism": "Rat", "refseq_name": "protein arginine N-methyltransferase 3", "refseq_ac": [ { "id": "NP_446009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446009", "type": "external" } ], "gene_names_uniprotkb": "Prmt3; Hrmt1l3", "gene_names_refseq": "Hrmt1l3; Prmt3", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 3; 2.1.1.319; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein methyltransferase-like 3; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3; protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3; protein arginine N-methyltransferase 3", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:89820); (R-RNO-3214858); (R-RNO-8876725)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10899106;10931850;15334060;20647003;24815167;9642256", "class_list": "", "function": "PRMT3 possibly plays a pivotal role in neuronal translation by contributing to activity-dependent changes in the dendritic spines., [RefSeq, PubMed]; Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:10899106, PubMed:15334060, PubMed:9642256). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (By similarity). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (By similarity). Promotes osteogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suggest that interaction between PRMT3 and RhoGDI-alpha mediates mycophenolic acid-induced pancreatic beta-cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008168 methyltransferase activity;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006355 regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0018216 peptidyl-arginine methylation;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70467-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6YP92-1", "uniprot_id": [ { "id": "ARX_RAT", "url": "https://www.uniprot.org/uniprot/A6YP92", "type": "external" } ], "mass": 58647.0, "length": 566, "protein_name": "Homeobox protein ARX", "gene_name": "Arx", "organism": "Rat", "refseq_name": "homeobox protein ARX", "refseq_ac": [ { "id": "NP_001093644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093644", "type": "external" } ], "gene_names_uniprotkb": "Arx", "gene_names_refseq": "Arx; RGD1562672", "protein_names_uniprotkb": "Homeobox protein ARX; Aristaless-related homeobox", "protein_names_refseq": "homeobox protein ARX", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); developmental and epileptic encephalopathy 1 (Disease Ontology:DOID:0080468); non-syndromic X-linked intellectual disability ARX-related (Disease Ontology:DOID:0112021); corpus callosum agenesis-abnormal genitalia syndrome (Disease Ontology:DOID:0112151); X-linked lissencephaly 2 (Disease Ontology:DOID:0112238); Partington syndrome (Disease Ontology:DOID:14744); epilepsy (Disease Ontology:DOID:1826); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:317268)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34871948", "class_list": "", "function": "DNA-binding transcription factor that plays a central role in the differentiation and development of type A pancreatic cells, which are located in the islets of Langerhans and secrete glucagon. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes. Also plays a key role in intestinal enteroendocrine cell differentiation by promoting differentiation of intestinal enteroendocrine cell types L, -N, -D, -I and -G. Required for normal brain development: plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate. Promotes expression of transcription of KDM5C (By similarity). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; L-Methionine prevents beta-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats., [RefSeq, PubMed]; Transcription factor. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes, such as histone demethylase KDM5C. Positively modulates transcription of KDM5C. Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. Required for normal brain development. Plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6YP92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7U2-1", "uniprot_id": [ { "id": "CARTF_RAT", "url": "https://www.uniprot.org/uniprot/D4A7U2", "type": "external" } ], "mass": 64667.0, "length": 587, "protein_name": "Calcium-responsive transcription factor", "gene_name": "Carf", "organism": "Rat", "refseq_name": "calcium-responsive transcription factor isoform 3", "refseq_ac": [ { "id": "NP_001100385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100385", "type": "external" } ], "gene_names_uniprotkb": "Carf; Als2cr8", "gene_names_refseq": "Als2cr8; Carf", "protein_names_uniprotkb": "Calcium-responsive transcription factor; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; CaRF; Calcium-response factor", "protein_names_refseq": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; calcium-response factor; calcium-responsive transcription factor isoform 3", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (rno:301446)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11832226", "class_list": "", "function": "Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001652 granular component", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7U2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08560-1", "uniprot_id": [ { "id": "DGKZ_RAT", "url": "https://www.uniprot.org/uniprot/O08560", "type": "external" } ], "mass": 104009.0, "length": 929, "protein_name": "Diacylglycerol kinase zeta", "gene_name": "Dgkz", "organism": "Rat", "refseq_name": "diacylglycerol kinase zeta isoform 2", "refseq_ac": [ { "id": "NP_112405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112405", "type": "external" } ], "gene_names_uniprotkb": "Dgkz; Dagk6", "gene_names_refseq": "Dgkz", "protein_names_uniprotkb": "Diacylglycerol kinase zeta; 104 kDa diacylglycerol kinase; 2.7.1.107; 2.7.1.93; DAG kinase zeta; DGK-IV; DGK-zeta; Diglyceride kinase zeta", "protein_names_refseq": "104 kDa diacylglycerol kinase; DAG kinase zeta; DGK-IV; DGK-zeta; diacylglycerol kinase zeta isoform 2; diglyceride kinase zeta", "tax_id": 10116, "disease": "", "pathway": " (rno:81821); (R-RNO-114508)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14511325;15157668;15542238;23467923;24893663;34312706;8855332", "class_list": "", "function": "DGK zeta is primarily a nuclear protein in neurons, it can also be cytoplasmic in some conditions, and the subcellular location depends not only on the cell type but also on the developmental state or growth conditions of the cell., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity). Regulates RASGRP1 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Diacylglycerol kinase zeta might be involved in the process of selective vulnerability of hippocampal pyramidal neurons in postischemic brain, [RefSeq, PubMed]; The DGKzeta and DGKalpha localize predominantly to the nucleus of ganglion cells., [RefSeq, PubMed]; The expression of diacylglycerol kinase isoforms alpha and zeta correlates with the progression of experimental autoimmune encephalomyelitis in rats., [RefSeq, PubMed]; The results suggest that DGKzeta cytoplasmic translocation in neurons under hypoxic stress is regulated by some mechanism which differs from that mediated by NAP1-like proteins., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0001727 lipid kinase activity;GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0004857 enzyme inhibitor activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08560-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00786-1", "uniprot_id": [ { "id": "CATH_RAT", "url": "https://www.uniprot.org/uniprot/P00786", "type": "external" } ], "mass": 37104.0, "length": 333, "protein_name": "Pro-cathepsin H", "gene_name": "Ctsh", "organism": "Rat", "refseq_name": "pro-cathepsin H precursor", "refseq_ac": [ { "id": "NP_037071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037071", "type": "external" } ], "gene_names_uniprotkb": "Ctsh", "gene_names_refseq": "Ctsh", "protein_names_uniprotkb": "Pro-cathepsin H", "protein_names_refseq": "cathepsin B3; cathepsin BA; pro-cathepsin H precursor; pro-cathepsin H", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); Huntington's disease (Disease Ontology:DOID:12858); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (rno:25425); (R-RNO-2132295); (R-RNO-5683826); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21217776;2276418;23103411;24982147;2759235;27998776;3691815;6574504", "class_list": "", "function": "CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression., [RefSeq, PubMed]; Cathepsin H is an active participant in lysosome-mediated pre-hormone degradation, and follicular Tg stimulates mobilization of pre-hormones by activating cathepsin H-associated proteolysis pathways, [RefSeq, PubMed]; Important for the overall degradation of proteins in lysosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only., [RefSeq, PubMed]; The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0070324 thyroid hormone binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005764 lysosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0006955 immune response;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00786-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5P5-1", "uniprot_id": [ { "id": "ARMC9_RAT", "url": "https://www.uniprot.org/uniprot/A1A5P5", "type": "external" } ], "mass": 82337.0, "length": 730, "protein_name": "LisH domain-containing protein ARMC9", "gene_name": "Armc9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Armc9", "gene_names_refseq": "", "protein_names_uniprotkb": "LisH domain-containing protein ARMC9", "protein_names_refseq": "", "tax_id": 10116, "disease": "Joubert syndrome 30 (Disease Ontology:DOID:0080275)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity). Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0097542 ciliary tip", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5P5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V735-1", "uniprot_id": [ { "id": "AMOL2_RAT", "url": "https://www.uniprot.org/uniprot/G3V735", "type": "external" } ], "mass": 85587.0, "length": 773, "protein_name": "Angiomotin-like protein 2", "gene_name": "Amotl2", "organism": "Rat", "refseq_name": "angiomotin-like protein 2", "refseq_ac": [ { "id": "NP_113905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113905", "type": "external" } ], "gene_names_uniprotkb": "Amotl2", "gene_names_refseq": "Amotl2; Lccp", "protein_names_uniprotkb": "Angiomotin-like protein 2", "protein_names_refseq": "Leman coiled-coil protein; angiomotin-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:65157); (R-RNO-2028269)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "39027975", "class_list": "", "function": "Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (By similarity). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (By similarity). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (By similarity). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells., [UniProtKB, UniProtKB, UniProtKB]; Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0055037 recycling endosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V735-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70210-1", "uniprot_id": [ { "id": "CHAD_RAT", "url": "https://www.uniprot.org/uniprot/O70210", "type": "external" } ], "mass": 40404.0, "length": 358, "protein_name": "Chondroadherin", "gene_name": "Chad", "organism": "Rat", "refseq_name": "chondroadherin precursor", "refseq_ac": [ { "id": "NP_062037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062037", "type": "external" } ], "gene_names_uniprotkb": "Chad", "gene_names_refseq": "Chad", "protein_names_uniprotkb": "Chondroadherin; Cartilage leucine-rich protein", "protein_names_refseq": "cartilage leucine-rich protein; chondroadherin precursor", "tax_id": 10116, "disease": "common variable immunodeficiency 7 (Disease Ontology:DOID:0081150); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); systemic lupus erythematosus (Disease Ontology:DOID:9074); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:29195)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9461555", "class_list": "", "function": "Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060348 bone development;GO:0001502 cartilage condensation;GO:1900155 negative regulation of bone trabecula formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70210-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02764-1", "uniprot_id": [ { "id": "A1AG_RAT", "url": "https://www.uniprot.org/uniprot/P02764", "type": "external" } ], "mass": 23575.0, "length": 205, "protein_name": "Alpha-1-acid glycoprotein", "gene_name": "Orm1", "organism": "Rat", "refseq_name": "alpha-1-acid glycoprotein precursor", "refseq_ac": [ { "id": "NP_445740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445740", "type": "external" } ], "gene_names_uniprotkb": "Orm1", "gene_names_refseq": "AAG; AGP; Agpa1; OMD; Orm1; Orm", "protein_names_uniprotkb": "Alpha-1-acid glycoprotein; OMD; Orosomucoid", "protein_names_refseq": "alpha-1-acid glycoprotein precursor; alpha-1-acid glycoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:24614); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "26740279;2943986;30707086;33134382;3838547;6270146;7263664", "class_list": "", "function": "Although infarct volumes did not differ, septic embolic stroke caused higher mortality than sterile embolic stroke. Brain abscesses were observed only in the septic group. Approximately 400-500 fold increases were observed for Orm1 and Cxcl2 respectively in the septic group compared to the sterile group, and these were the most dramatically regulated genes in septic embolic stroke compared to sterile embolic stroke., [RefSeq, PubMed]; Fatigue upregulates the level of ORM1, which in turn functions as an anti-fatigue protein to enhance muscle endurance via the CCR5 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling. Erratum:[Biomed Res Int. 2022 Jul 4;2022:9828942. doi: 10.1155/2022/9828942. PMID: 35832841] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 6, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1904681 response to 3-methylcholanthrene;GO:0071378 cellular response to growth hormone stimulus;GO:0032496 response to lipopolysaccharide;GO:0071300 cellular response to retinoic acid;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P02764-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RUV9-1", "uniprot_id": [ { "id": "AEBP1_RAT", "url": "https://www.uniprot.org/uniprot/A2RUV9", "type": "external" } ], "mass": 128061.0, "length": 1128, "protein_name": "Adipocyte enhancer-binding protein 1", "gene_name": "Aebp1", "organism": "Rat", "refseq_name": "adipocyte enhancer-binding protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001094440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094440", "type": "external" } ], "gene_names_uniprotkb": "Aebp1; Aclp", "gene_names_refseq": "Aebp1", "protein_names_uniprotkb": "Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein", "protein_names_refseq": "adipocyte enhancer-binding protein 1 isoform 1 precursor; adipocyte enhancer-binding protein 1; aortic carboxypeptidase-like protein", "tax_id": 10116, "disease": "Ehlers-Danlos syndrome classic-like 2 (Disease Ontology:DOID:0080732)", "pathway": " (rno:305494)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11738825;29393594;9624159", "class_list": "", "function": "As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix (By similarity). May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0005518 collagen binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription;GO:1904026 regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2RUV9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD32-1", "uniprot_id": [ { "id": "CHD5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD32", "type": "external" } ], "mass": 222263.0, "length": 1948, "protein_name": "ATP-dependent chromatin remodeler CHD5", "gene_name": "Chd3; Chd5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chd3; Chd5", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD5; 3.6.4.-; CHD-5; Chromo domain-containing protein 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-RNO-3214815); (R-RNO-6804758); (R-RNO-73762); (R-RNO-8943724); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "21931736;22673903", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZD32-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3T6-1", "uniprot_id": [ { "id": "AGRF2_RAT", "url": "https://www.uniprot.org/uniprot/D4A3T6", "type": "external" } ], "mass": 70830.0, "length": 638, "protein_name": "Adhesion G protein-coupled receptor F2", "gene_name": "Adgrf2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adgrf2; Gpr111; Pgr20", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F2; G protein-coupled receptor 111; G protein-coupled receptor PGR20", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009268 response to pH;GO:0034505 tooth mineralization;GO:0070166 enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3T6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAU5-1", "uniprot_id": [ { "id": "CATIP_RAT", "url": "https://www.uniprot.org/uniprot/M0RAU5", "type": "external" } ], "mass": 55767.0, "length": 489, "protein_name": "Ciliogenesis-associated TTC17-interacting protein", "gene_name": "Catip", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Catip", "gene_names_refseq": "", "protein_names_uniprotkb": "Ciliogenesis-associated TTC17-interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 54 (Disease Ontology:DOID:0112335)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "24475127", "class_list": "", "function": "Plays a role in primary ciliogenesis by modulating actin polymerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030041 actin filament polymerization;GO:0044782 cilium organization;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0RAU5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H299-1", "uniprot_id": [ { "id": "DCA17_RAT", "url": "https://www.uniprot.org/uniprot/B1H299", "type": "external" } ], "mass": 56450.0, "length": 505, "protein_name": "DDB1- and CUL4-associated factor 17", "gene_name": "Dcaf17", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 17 isoform 1", "refseq_ac": [ { "id": "NP_001171159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171159", "type": "external" } ], "gene_names_uniprotkb": "Dcaf17", "gene_names_refseq": "Dcaf17; RGD1565551", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 17", "protein_names_refseq": "DDB1- and CUL4-associated factor 17 isoform 1", "tax_id": 10116, "disease": "Woodhouse-Sakati syndrome (Disease Ontology:DOID:0112264)", "pathway": " (rno:499807); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016020 membrane;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0000902 cell morphogenesis;GO:0016567 protein ubiquitination;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1H299-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPN3-1", "uniprot_id": [ { "id": "BPIB1_RAT", "url": "https://www.uniprot.org/uniprot/A0JPN3", "type": "external" } ], "mass": 52219.0, "length": 471, "protein_name": "BPI fold-containing family B member 1", "gene_name": "Bpifb1", "organism": "Rat", "refseq_name": "BPI fold-containing family B member 1 precursor", "refseq_ac": [ { "id": "NP_001071148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071148", "type": "external" } ], "gene_names_uniprotkb": "Bpifb1; Lplunc1", "gene_names_refseq": "Bpifb1; Lplunc1; RGD1563047", "protein_names_uniprotkb": "BPI fold-containing family B member 1; Long palate, lung and nasal epithelium carcinoma-associated protein 1", "protein_names_refseq": "BPI fold-containing family B member 1 precursor; fold containing family B, member 1; long palate, lung and nasal epithelium carcinoma-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:499926); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0002227 innate immune response in mucosa;GO:0034144 negative regulation of toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08697-1", "uniprot_id": [ { "id": "ARL2_RAT", "url": "https://www.uniprot.org/uniprot/O08697", "type": "external" } ], "mass": 20836.0, "length": 184, "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "Arl2", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 2", "refseq_ac": [ { "id": "NP_113899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113899", "type": "external" } ], "gene_names_uniprotkb": "Arl2; Arl184", "gene_names_refseq": "Arl2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2", "protein_names_refseq": "ADP-ribosylation factor like GTPase 2; ADP-ribosylation factor-like 2; ADP-ribosylation factor-like protein 2; ADP-ribosylation-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:65142); (R-RNO-83936); (R-RNO-9648002)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11809823;12527357;12912990;20007690;22673903;9208929", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggest that miR-15b may decrease mitochondrial integrity by targeting Arl2 in the heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0015870 acetylcholine transport;GO:0006110 regulation of glycolytic process;GO:0010811 positive regulation of cell-substrate adhesion;GO:0031113 regulation of microtubule polymerization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPP8-1", "uniprot_id": [ { "id": "CCD61_RAT", "url": "https://www.uniprot.org/uniprot/A0JPP8", "type": "external" } ], "mass": 57730.0, "length": 512, "protein_name": "Centrosomal protein CCDC61", "gene_name": "Ccdc61", "organism": "Rat", "refseq_name": "centrosomal protein CCDC61", "refseq_ac": [ { "id": "NP_001099699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099699", "type": "external" } ], "gene_names_uniprotkb": "Ccdc61; VFL3", "gene_names_refseq": "Ccdc61; RGD1307390", "protein_names_uniprotkb": "Centrosomal protein CCDC61; Coiled-coil domain-containing protein 61; VFL3 homolog", "protein_names_refseq": "VFL3 homolog; centrosomal protein CCDC61; coiled-coil domain-containing protein 61", "tax_id": 10116, "disease": "", "pathway": " (rno:292680)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body;GO:0120103 centriolar subdistal appendage", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0030030 cell projection organization;GO:0098534 centriole assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JPP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Q4-1", "uniprot_id": [ { "id": "CF206_RAT", "url": "https://www.uniprot.org/uniprot/A1A5Q4", "type": "external" } ], "mass": 70835.0, "length": 622, "protein_name": "Cilia- and flagella-associated protein 206", "gene_name": "Cfap206", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 206", "refseq_ac": [ { "id": "NP_001073169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073169", "type": "external" } ], "gene_names_uniprotkb": "Cfap206", "gene_names_refseq": "Cfap206; RGD1310641", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 206", "protein_names_refseq": "UPF0704 protein C6orf165 homolog; cilia- and flagella-associated protein 206", "tax_id": 10116, "disease": "", "pathway": " (rno:366347)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007338 single fertilization;GO:0003341 cilium movement;GO:0003356 regulation of cilium beat frequency;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Q4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1IGU3-1", "uniprot_id": [ { "id": "ARH37_RAT", "url": "https://www.uniprot.org/uniprot/A1IGU3", "type": "external" } ], "mass": 76407.0, "length": 676, "protein_name": "Rho guanine nucleotide exchange factor 37", "gene_name": "Arhgef37", "organism": "Rat", "refseq_name": "rho guanine nucleotide exchange factor 37", "refseq_ac": [ { "id": "NP_001094444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094444", "type": "external" } ], "gene_names_uniprotkb": "Arhgef37", "gene_names_refseq": "Arhgef37; RGD1560471", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 37; Protein 2-88; Scaffold protein tuba 3", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 37; probable guanine nucleotide exchange factor FLJ41603 homolog; protein 2-88; rho guanine nucleotide exchange factor 37; scaffold protein tuba 3", "tax_id": 10116, "disease": "", "pathway": " (rno:307398); (R-RNO-193648); (R-RNO-416482)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF) involved in clathrin-mediated endocytosis, probably playing a role in the late stages of the process (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1IGU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1K4-1", "uniprot_id": [ { "id": "C42S2_RAT", "url": "https://www.uniprot.org/uniprot/A1L1K4", "type": "external" } ], "mass": 9095.0, "length": 83, "protein_name": "CDC42 small effector protein 2", "gene_name": "Cdc42se2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdc42se2; Cdc42se2-ps1", "gene_names_refseq": "", "protein_names_uniprotkb": "CDC42 small effector protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:691031)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DFF3", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1L1K4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1L1-1", "uniprot_id": [ { "id": "CENPW_RAT", "url": "https://www.uniprot.org/uniprot/A1L1L1", "type": "external" } ], "mass": 9803.0, "length": 86, "protein_name": "Centromere protein W", "gene_name": "Cenpw", "organism": "Rat", "refseq_name": "centromere protein W", "refseq_ac": [ { "id": "NP_001233248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001233248", "type": "external" } ], "gene_names_uniprotkb": "Cenpw; Cug2", "gene_names_refseq": "CENP-W; Cenpw", "protein_names_uniprotkb": "Centromere protein W; CENP-W; Cancer-up-regulated gene 2 protein", "protein_names_refseq": "cancer-up-regulated gene 2 protein; centromere protein W", "tax_id": 10116, "disease": "", "pathway": " (rno:689399); (R-RNO-606279)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000775 chromosome, centromeric region;GO:0016363 nuclear matrix", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L1L1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VCW9-1", "uniprot_id": [ { "id": "AASS_RAT", "url": "https://www.uniprot.org/uniprot/A2VCW9", "type": "external" } ], "mass": 102908.0, "length": 926, "protein_name": "Alpha-aminoadipic semialdehyde synthase, mitochondrial", "gene_name": "Aass", "organism": "Rat", "refseq_name": "alpha-aminoadipic semialdehyde synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001094433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094433", "type": "external" } ], "gene_names_uniprotkb": "Aass", "gene_names_refseq": "Aass", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH", "protein_names_refseq": "LKR/SDH; alpha-aminoadipic semialdehyde synthase, mitochondrial precursor; alpha-aminoadipic semialdehyde synthase, mitochondrial", "tax_id": 10116, "disease": "hyperlysinemia (Disease Ontology:DOID:9274)", "pathway": " (rno:296925); (R-RNO-71064)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that catalyzes the first two steps in lysine degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.8", "type": "external" }, { "id": "1.5.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.9", "type": "external" } ], "go_molecular_function": "GO:0004753 saccharopine dehydrogenase activity;GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006554 lysine catabolic process;GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0019477 L-lysine catabolic process;GO:0006553 lysine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VCW9-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5HK05-1", "uniprot_id": [ { "id": "APBP2_RAT", "url": "https://www.uniprot.org/uniprot/A5HK05", "type": "external" } ], "mass": 66902.0, "length": 585, "protein_name": "Amyloid protein-binding protein 2", "gene_name": "Appbp2", "organism": "Rat", "refseq_name": "amyloid protein-binding protein 2", "refseq_ac": [ { "id": "NP_001094439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094439", "type": "external" } ], "gene_names_uniprotkb": "Appbp2", "gene_names_refseq": "Appbp2; PAT1", "protein_names_uniprotkb": "Amyloid protein-binding protein 2; APP-BP2; Amyloid beta precursor protein-binding protein 2", "protein_names_refseq": "APP-BP2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; amyloid protein-binding protein 2; protein interacting with APP tail 1", "tax_id": 10116, "disease": "", "pathway": " (rno:303396)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (By similarity). The CRL2(APPBP2) complex negatively regulates beige adipocyte differentiation by mediating ubiquitination and degradation of PRDM16 (By similarity). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJX9", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005874 microtubule;GO:0030659 cytoplasmic vesicle membrane;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway;GO:0160276 negative regulation of beige fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5HK05-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNA9-1", "uniprot_id": [ { "id": "CNO11_RAT", "url": "https://www.uniprot.org/uniprot/B0BNA9", "type": "external" } ], "mass": 54836.0, "length": 504, "protein_name": "CCR4-NOT transcription complex subunit 11", "gene_name": "Cnot11", "organism": "Rat", "refseq_name": "CCR4-NOT transcription complex subunit 11", "refseq_ac": [ { "id": "NP_001102264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102264", "type": "external" } ], "gene_names_uniprotkb": "Cnot11", "gene_names_refseq": "Cnot11; RGD1560909", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 11", "protein_names_refseq": "CCR4-NOT transcription complex subunit 11; UPF0760 protein C2orf29 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:363221); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Does not seem to be required for complex deadenylase function (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNA9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNL6-1", "uniprot_id": [ { "id": "ARRD1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNL6", "type": "external" } ], "mass": 46109.0, "length": 434, "protein_name": "Arrestin domain-containing protein 1", "gene_name": "Arrdc1", "organism": "Rat", "refseq_name": "arrestin domain-containing protein 1", "refseq_ac": [ { "id": "NP_001094240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094240", "type": "external" } ], "gene_names_uniprotkb": "Arrdc1", "gene_names_refseq": "Arrdc1", "protein_names_uniprotkb": "Arrestin domain-containing protein 1; Alpha-arrestin 1", "protein_names_refseq": "alpha-arrestin 1; arrestin domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:366001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23886940", "class_list": "", "function": "Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FT0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:1990763 arrestin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006858 extracellular transport;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BNL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNN3-1", "uniprot_id": [ { "id": "CAH1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNN3", "type": "external" } ], "mass": 28300.0, "length": 261, "protein_name": "Carbonic anhydrase 1", "gene_name": "Ca1", "organism": "Rat", "refseq_name": "carbonic anhydrase 1", "refseq_ac": [ { "id": "NP_001101130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101130", "type": "external" } ], "gene_names_uniprotkb": "Ca1; Car1", "gene_names_refseq": "CA-I; Ca1; Car1", "protein_names_uniprotkb": "Carbonic anhydrase 1; 4.2.1.1; 4.2.1.69; CA-I; Carbonate dehydratase I; Carbonic anhydrase I; Cyanamide hydratase CA1", "protein_names_refseq": "carbonic anhydrase 1; carbonic anhydrase I; cyanamide hydratase CA1", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colitis (Disease Ontology:DOID:0060180); Graves ophthalmopathy (Disease Ontology:DOID:0081120); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); major depressive disorder (Disease Ontology:DOID:1470); viral hepatitis (Disease Ontology:DOID:1884); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:310218); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-1475029)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19343716;24670789;29393594;34502162", "class_list": "", "function": "Catalyzes the reversible hydration of carbon dioxide. Can hydrate cyanamide to urea., [UniProtKB, UniProtKB]; Myocardial carbonic anhydrase 1/2 activation is significantly elevated in diabetic ischemic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004064 arylesterase activity;GO:0016836 hydro-lyase activity;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009750 response to fructose", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B0BNN3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0K019-1", "uniprot_id": [ { "id": "BAG1_RAT", "url": "https://www.uniprot.org/uniprot/B0K019", "type": "external" } ], "mass": 40160.0, "length": 358, "protein_name": "BAG family molecular chaperone regulator 1", "gene_name": "Bag1", "organism": "Rat", "refseq_name": "BAG family molecular chaperone regulator 1 isoform 1L", "refseq_ac": [ { "id": "NP_001100117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100117", "type": "external" } ], "gene_names_uniprotkb": "Bag1", "gene_names_refseq": "Bag-1; Bag1", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1", "protein_names_refseq": "BAG family molecular chaperone regulator 1 isoform 1L; BAG family molecular chaperone regulator 1; BCL2-associated athanogene; Bcl2 associated athanogene 1; bcl-2-associated athanogene 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); lesion of sciatic nerve (Disease Ontology:DOID:12528); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); cervix carcinoma (Disease Ontology:DOID:2893)", "pathway": " (rno:297994); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17546604;21808025;23108487;33025573;9396724", "class_list": "", "function": "BAG-1 has a role in supporting viability and matrix expression of chondrocytes, [RefSeq, PubMed]; BAG1 expression increased progressively after sciatic nerve crush, reached a peak 2 weeks post-injury. It returned to the normal level 4 weeks post-injury. Spatially, BAG1 was mainly expressed in Schwann cells., [RefSeq, PubMed]; Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience., [RefSeq, PubMed]; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (PubMed:21808025)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Shows that the human and mouse orthologs use alternative translation initiation codons, including a non-AUG(CUG) codon., [RefSeq, PubMed]; The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. Studies in human and mouse suggest that the protein encoded by this gene (referred to as Bcl2-associated athanogene) binds to Bcl2 protein. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0051219 phosphoprotein binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0035094 response to nicotine;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B0K019-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0K020-1", "uniprot_id": [ { "id": "CISD1_RAT", "url": "https://www.uniprot.org/uniprot/B0K020", "type": "external" } ], "mass": 12097.0, "length": 108, "protein_name": "CDGSH iron-sulfur domain-containing protein 1", "gene_name": "Cisd1", "organism": "Rat", "refseq_name": "CDGSH iron-sulfur domain-containing protein 1", "refseq_ac": [ { "id": "NP_001099855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099855", "type": "external" } ], "gene_names_uniprotkb": "Cisd1", "gene_names_refseq": "Cisd1; MitoNEET; RGD1309529", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 1; 2.6.1.3; Cysteine transaminase CISD1; MitoNEET", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 1; cysteine transaminase CISD1", "tax_id": 10116, "disease": "", "pathway": " (rno:294362)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14570702;17376863;19348892;27748416;33723216;37269467", "class_list": "", "function": "Describes methods for isolating mitochondrial membrane fractions that are enriched in mitoNEET, generating constructs for the expression of recombinant mitoNEET protein and analyzing the 2Fe-2S cluster of mitoNEET in vitro, [RefSeq, PubMed]; L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (By similarity). The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine). The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate. The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (By similarity). Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in iron-sulfur cluster shuttling and/or in redox reactions. Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-127-3p targeting CISD1 regulates autophagy in hypoxic-ischemic cortex. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-127 targets mitoNEET, which inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection Erratum:[Sci Rep. 2017 Jan 19;7:39570. doi: 10.1038/srep39570. PMID: 28102200] Publication Status: Online-Only, [RefSeq, PubMed]; Mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates [mitoNEET], [RefSeq, PubMed]; MitoNEET is located in mitochondrial fraction of rat brain, liver and skeletal muscle., [RefSeq, PubMed]; MitoNEET prevents iron overload-induced insulin resistance in H9c2 cells through regulation of mitochondrial iron. Erratum:[J Cell Physiol. 2024 Dec;239(12):e31456. doi: 10.1002/jcp.31456. PMID: 39350514], [RefSeq, PubMed]; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0047801 L-cysteine transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0032473 cytoplasmic side of mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0010506 regulation of autophagy;GO:0006879 intracellular iron ion homeostasis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B0K020-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBW4-1", "uniprot_id": [ { "id": "ARM10_RAT", "url": "https://www.uniprot.org/uniprot/B1WBW4", "type": "external" } ], "mass": 33422.0, "length": 306, "protein_name": "Armadillo repeat-containing protein 10", "gene_name": "Armc10", "organism": "Rat", "refseq_name": "armadillo repeat-containing protein 10", "refseq_ac": [ { "id": "NP_001100046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100046", "type": "external" } ], "gene_names_uniprotkb": "Armc10", "gene_names_refseq": "2810037c14rik; Armc10; RGD1305915", "protein_names_uniprotkb": "Armadillo repeat-containing protein 10", "protein_names_refseq": "SVH protein; armadillo repeat-containing protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:296758)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002039 p53 binding;GO:0050692 DNA binding domain binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0040010 positive regulation of growth rate;GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WBW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUW6-1", "uniprot_id": [ { "id": "AEN_RAT", "url": "https://www.uniprot.org/uniprot/B2GUW6", "type": "external" } ], "mass": 37061.0, "length": 332, "protein_name": "Apoptosis-enhancing nuclease", "gene_name": "Aen", "organism": "Rat", "refseq_name": "apoptosis-enhancing nuclease", "refseq_ac": [ { "id": "NP_001101957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101957", "type": "external" } ], "gene_names_uniprotkb": "Aen; Isg20l1", "gene_names_refseq": "Aen; Isg20l1; RGD1305051", "protein_names_uniprotkb": "Apoptosis-enhancing nuclease; 3.1.-.-; Interferon-stimulated 20 kDa exonuclease-like 1", "protein_names_refseq": "apoptosis-enhancing nuclease; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361594)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity;GO:0004529 DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GUW6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV17-1", "uniprot_id": [ { "id": "CBPC5_RAT", "url": "https://www.uniprot.org/uniprot/B2GV17", "type": "external" } ], "mass": 92554.0, "length": 832, "protein_name": "Cytosolic carboxypeptidase-like protein 5", "gene_name": "Agbl5", "organism": "Rat", "refseq_name": "cytosolic carboxypeptidase-like protein 5", "refseq_ac": [ { "id": "NP_001119844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119844", "type": "external" } ], "gene_names_uniprotkb": "Agbl5; Ccp5", "gene_names_refseq": "Agbl5", "protein_names_uniprotkb": "Cytosolic carboxypeptidase-like protein 5; 3.4.17.-; 3.4.17.24; ATP/GTP-binding protein-like 5; Protein deglutamylase CCP5", "protein_names_refseq": "ATP/GTP binding protein-like 5; cytosolic carboxypeptidase-like protein 5; protein deglutamylase CCP5", "tax_id": 10116, "disease": "retinitis pigmentosa 75 (Disease Ontology:DOID:0110361)", "pathway": " (rno:362710)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0030496 midbody", "go_biological_process": "GO:0006508 proteolysis;GO:0051607 defense response to virus;GO:0035608 protein deglutamylation;GO:0035611 protein branching point deglutamylation;GO:0035610 protein side chain deglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV17-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV52-1", "uniprot_id": [ { "id": "BL1S5_RAT", "url": "https://www.uniprot.org/uniprot/B2GV52", "type": "external" } ], "mass": 21539.0, "length": 187, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 5", "gene_name": "Bloc1s5", "organism": "Rat", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 5", "refseq_ac": [ { "id": "NP_001100817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100817", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s5; Muted; Mu", "gene_names_refseq": "Bloc1s5; Muted", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 5; BLOC-1 subunit 5; Protein Muted homolog", "protein_names_refseq": "BLOC-1 subunit 5; biogenesis of lysosomal organelles complex-1, subunit 5, muted; biogenesis of lysosome-related organelles complex 1 subunit 5; protein Muted homolog", "tax_id": 10116, "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (rno:306868)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16760431", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex;GO:1990742 microvesicle", "go_biological_process": "GO:0032474 otolith morphogenesis;GO:0031175 neuron projection development;GO:0016192 vesicle-mediated transport;GO:0008089 anterograde axonal transport;GO:0035646 endosome to melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GV52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYJ4-1", "uniprot_id": [ { "id": "ADPPT_RAT", "url": "https://www.uniprot.org/uniprot/B2RYJ4", "type": "external" } ], "mass": 35816.0, "length": 309, "protein_name": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "gene_name": "Aasdhppt", "organism": "Rat", "refseq_name": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase", "refseq_ac": [ { "id": "NP_001100268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100268", "type": "external" } ], "gene_names_uniprotkb": "Aasdhppt", "gene_names_refseq": "Aasdhppt", "protein_names_uniprotkb": "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; 2.7.8.7; 4'-phosphopantetheinyl transferase; AASD-PPT; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase", "protein_names_refseq": "4'-phosphopantetheinyl transferase; AASD-PPT; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase", "tax_id": 10116, "disease": "", "pathway": " (rno:300328); (R-RNO-199220)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.7", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008897 holo-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019878 lysine biosynthetic process via aminoadipic acid;GO:0009258 10-formyltetrahydrofolate catabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYM5-1", "uniprot_id": [ { "id": "BRCC3_RAT", "url": "https://www.uniprot.org/uniprot/B2RYM5", "type": "external" } ], "mass": 33016.0, "length": 291, "protein_name": "Lys-63-specific deubiquitinase BRCC36", "gene_name": "Brcc3", "organism": "Rat", "refseq_name": "lys-63-specific deubiquitinase BRCC36", "refseq_ac": [ { "id": "NP_001120772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120772", "type": "external" } ], "gene_names_uniprotkb": "Brcc3; Brcc36", "gene_names_refseq": "Brcc3l1; Brcc3", "protein_names_uniprotkb": "Lys-63-specific deubiquitinase BRCC36; 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRISC complex subunit BRCC36", "protein_names_refseq": "BRCA1/BRCA2-containing complex, subunit 3 like 1; lys-63-specific deubiquitinase BRCC36", "tax_id": 10116, "disease": "", "pathway": " (rno:316794); (R-RNO-5689901); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "29393594;31184779;33979701", "class_list": "", "function": "BRCC3 expressed in oligodendrocyte precursor cells in vitro is required for the oligodendrocyte lineage progression toward the mature stage. Lack of BRCC3 function could deteriorate demyelination at the lesion site. An increase in Lys63-linked ubiquitination levels induced by the deregulation of BRCC3 expression promotes the endosomal/lysosomal processing of myelin proteins., [RefSeq, PubMed]; BRCC3 promotes activation of the NLRP6 inflammasome following cerebral ischemia/reperfusion (I/R) injury in rats., [RefSeq, PubMed]; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (By similarity). Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly (By similarity). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (By similarity). Deubiquitinates HDAC1 and PWWP2B leading to their stabilization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0046872 metal ion binding;GO:0030234 enzyme regulator activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070552 BRISC complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006508 proteolysis;GO:0051301 cell division;GO:0070536 protein K63-linked deubiquitination;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RYM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ86-1", "uniprot_id": [ { "id": "CCD89_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ86", "type": "external" } ], "mass": 43453.0, "length": 370, "protein_name": "Coiled-coil domain-containing protein 89", "gene_name": "Ccdc89", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 89", "refseq_ac": [ { "id": "NP_001128305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128305", "type": "external" } ], "gene_names_uniprotkb": "Ccdc89; Boip", "gene_names_refseq": "Ccdc89; RGD1305335", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 89; Bc8 orange-interacting protein", "protein_names_refseq": "coiled-coil domain-containing protein 89", "tax_id": 10116, "disease": "", "pathway": " (rno:293107)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14648848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RZ86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3DMA2-1", "uniprot_id": [ { "id": "ACD11_RAT", "url": "https://www.uniprot.org/uniprot/B3DMA2", "type": "external" } ], "mass": 87371.0, "length": 779, "protein_name": "Acyl-CoA dehydrogenase family member 11", "gene_name": "Acad11", "organism": "Rat", "refseq_name": "acyl-CoA dehydrogenase family member 11", "refseq_ac": [ { "id": "NP_001101651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101651", "type": "external" } ], "gene_names_uniprotkb": "Acad11", "gene_names_refseq": "Acad11; RGD1306270", "protein_names_uniprotkb": "Acyl-CoA dehydrogenase family member 11; 1.3.8.8; ACAD-11", "protein_names_refseq": "ACAD-11; acyl-CoA dehydrogenase family member 11; acyl-Coenzyme A dehydrogenase family, member 11", "tax_id": 10116, "disease": "", "pathway": " (rno:315973); (R-RNO-77289)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14561759;29393594;30764676", "class_list": "", "function": "A significant up-regulation of Cpt1a, Acadl and Sirt3, all beta-oxidation genes, along with a significant deacetylation of the forkhead transcription factor 3a (FOXO3A) was found in alpha-LA-treated animals., [RefSeq, PubMed]; Participates in fatty acid beta-oxidation (FAO) and energy production in the central nervous system (CNS), and to a lesser extent in the liver. Catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, with maximal activity towards saturated docosanoyl-CoA (CoA 22:0) in both the cerebellum and the liver. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACADV and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed, such as the CNS, where together with ACAD9, they accommodate the full spectrum of long chain fatty acid substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity;GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B3DMA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3GSH5-1", "uniprot_id": [ { "id": "ASMT_RAT", "url": "https://www.uniprot.org/uniprot/B3GSH5", "type": "external" } ], "mass": 45588.0, "length": 432, "protein_name": "Acetylserotonin O-methyltransferase", "gene_name": "Asmt", "organism": "Rat", "refseq_name": "acetylserotonin O-methyltransferase", "refseq_ac": [ { "id": "NP_653360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653360", "type": "external" } ], "gene_names_uniprotkb": "Asmt; Hiomt", "gene_names_refseq": "Asmt", "protein_names_uniprotkb": "Acetylserotonin O-methyltransferase; 2.1.1.4; Hydroxyindole O-methyltransferase", "protein_names_refseq": "acetylserotonin O-methyltransferase; hydroxyindole O-methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:246281); (R-RNO-209931)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21437622;31124080;39149125;8574683;8930356", "class_list": "", "function": "Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Effects of acute hypothyroidism on plasma melatonin and Aanat and Asmt expression in the pineal gland and gonads of rats. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of HIOMT in epithelial cells of striated ducts in rat submandibular glands., [RefSeq, PubMed]; The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09179", "ec_number_list": [ { "id": "2.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0017096 acetylserotonin O-methyltransferase activity;GO:0046983 protein dimerization activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032259 methylation;GO:0030187 melatonin biosynthetic process;GO:2000019 negative regulation of male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B3GSH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3STU3-1", "uniprot_id": [ { "id": "CHAC1_RAT", "url": "https://www.uniprot.org/uniprot/B3STU3", "type": "external" } ], "mass": 24457.0, "length": 222, "protein_name": "Glutathione-specific gamma-glutamylcyclotransferase 1", "gene_name": "Chac1", "organism": "Rat", "refseq_name": "glutathione-specific gamma-glutamylcyclotransferase 1", "refseq_ac": [ { "id": "NP_001166908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166908", "type": "external" } ], "gene_names_uniprotkb": "Chac1; Botch; Npg7", "gene_names_refseq": "Chac1; RGD1307153", "protein_names_uniprotkb": "Glutathione-specific gamma-glutamylcyclotransferase 1; 4.3.2.7; Blocks Notch protein; Botch; Cation transport regulator-like protein 1; Gamma-GCG 1; Neuroprotective protein 7", "protein_names_refseq": "ChaC, cation transport regulator homolog 1; ChaC, cation transport regulator-like 1; blocks Notch protein; botch; cation transport regulator homolog 1; cation transport regulator-like protein 1; gamma-GCG 1; glutathione-specific gamma-glutamylcyclotransferase 1; neuroprotective protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:362196); (R-RNO-174403)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21124846;31377404", "class_list": "", "function": "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos., [UniProtKB, UniProtKB]; We found that Botch exerts neuroprotective effects via antagonizing the maturation of Notch1-induced neuronal injury and neuroinflammation after cerebral ischemia-reperfusion (I/R) injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0005112 Notch binding;GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006751 glutathione catabolic process;GO:0007219 Notch signaling pathway;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B3STU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFK7-1", "uniprot_id": [ { "id": "AB17C_RAT", "url": "https://www.uniprot.org/uniprot/B5DFK7", "type": "external" } ], "mass": 35098.0, "length": 320, "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "Abhd17c", "organism": "Rat", "refseq_name": "alpha/beta hydrolase domain-containing protein 17C", "refseq_ac": [ { "id": "NP_001094206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094206", "type": "external" } ], "gene_names_uniprotkb": "Abhd17c", "gene_names_refseq": "Abhd17c; Fam108c1; RGD1308210", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17C; 3.1.2.22; Abhydrolase domain-containing protein 17C", "protein_names_refseq": "abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; alpha/beta hydrolase domain-containing protein 17C; family with sequence similarity 108, member C1; protein ABHD17C", "tax_id": 10116, "disease": "", "pathway": " (rno:361601); (R-RNO-9648002)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27307232", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7U5", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:0002084 protein depalmitoylation;GO:0099175 regulation of postsynapse organization;GO:1902817 negative regulation of protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DFK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9R8-1", "uniprot_id": [ { "id": "ATP68_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9R8", "type": "external" } ], "mass": 6914.0, "length": 60, "protein_name": "ATP synthase subunit ATP5MPL, mitochondrial", "gene_name": "Atp5mpl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp5mpl", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase subunit ATP5MPL, mitochondrial; 6.8 kDa mitochondrial proteolipid protein; ATP synthase membrane subunit 6.8PL; MLQ", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17575325", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Minor subunit required to maintain the ATP synthase population in the mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9R8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35048-1", "uniprot_id": [ { "id": "3BHS7_RAT", "url": "https://www.uniprot.org/uniprot/O35048", "type": "external" } ], "mass": 37781.0, "length": 338, "protein_name": "3 beta-hydroxysteroid dehydrogenase type 7", "gene_name": "Hsd3b7", "organism": "Rat", "refseq_name": "3 beta-hydroxysteroid dehydrogenase type 7 isoform 2", "refseq_ac": [ { "id": "NP_647545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647545", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b7; Cca2", "gene_names_refseq": "Cca2; Hsd3b7", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase type 7; 1.1.1.-; 1.1.1.181; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; C(27) 3-beta-HSD; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; Confluent 3Y1 cell-associated 2", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase type 7 isoform 2; 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; c(27) 3-beta-HSD; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase; confluent 3Y1 cell-associated 2", "tax_id": 10116, "disease": "congenital bile acid synthesis defect 1 (Disease Ontology:DOID:0111071); intrahepatic cholestasis (Disease Ontology:DOID:1852)", "pathway": " (rno:246211); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16081591;9199244", "class_list": "", "function": "Results suggest that the mechanisms of regulation of these bile acid metabolizing enzymes are significantly different during liver regeneration, [RefSeq, PubMed]; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.181", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.181", "type": "external" } ], "go_molecular_function": "GO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001558 regulation of cell growth;GO:0035754 B cell chemotaxis;GO:0006694 steroid biosynthetic process;GO:0006707 cholesterol catabolic process;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35048-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUK3-1", "uniprot_id": [ { "id": "DLK2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUK3", "type": "external" } ], "mass": 40245.0, "length": 382, "protein_name": "Protein delta homolog 2", "gene_name": "Dlk2", "organism": "Rat", "refseq_name": "protein delta homolog 2 precursor", "refseq_ac": [ { "id": "NP_001101672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101672", "type": "external" } ], "gene_names_uniprotkb": "Dlk2; Egfl9", "gene_names_refseq": "DLK-2; Dlk2; Egfl9", "protein_names_uniprotkb": "Protein delta homolog 2; DLK-2; EGF-like protein 9; Endothelial cell-specific protein S-1; Epidermal growth factor-like protein 9", "protein_names_refseq": "EGF-like protein 9; EGF-like-domain, multiple 9; delta-like 2 homolog; endothelial cell-specific protein S-1; epidermal growth factor-like protein 9; protein delta homolog 2 precursor; protein delta homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates adipogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045746 negative regulation of Notch signaling pathway;GO:0045598 regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUK3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVN1-1", "uniprot_id": [ { "id": "COLL2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVN1", "type": "external" } ], "mass": 11495.0, "length": 104, "protein_name": "Colipase-like protein 2", "gene_name": "Clpsl2", "organism": "Rat", "refseq_name": "colipase-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001128474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128474", "type": "external" } ], "gene_names_uniprotkb": "Clpsl2", "gene_names_refseq": "Clpsl2", "protein_names_uniprotkb": "Colipase-like protein 2", "protein_names_refseq": "colipase-like protein 2 precursor; colipase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:689425)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007338 single fertilization;GO:0007340 acrosome reaction;GO:0007586 digestion;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWT9-1", "uniprot_id": [ { "id": "CLC6A_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWT9", "type": "external" } ], "mass": 24555.0, "length": 209, "protein_name": "C-type lectin domain family 6 member A", "gene_name": "CLEC6A", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CLEC6A", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 6 member A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (By similarity). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0001819 positive regulation of cytokine production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002250 adaptive immune response;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZWT9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZ07-1", "uniprot_id": [ { "id": "CAT7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZ07", "type": "external" } ], "mass": 37868.0, "length": 331, "protein_name": "Cathepsin 7", "gene_name": "Cts7", "organism": "Rat", "refseq_name": "cathepsin 7 precursor", "refseq_ac": [ { "id": "NP_001099569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099569", "type": "external" } ], "gene_names_uniprotkb": "Cts7", "gene_names_refseq": "Cts7", "protein_names_uniprotkb": "Cathepsin 7; 3.4.22.-", "protein_names_refseq": "cathepsin 7 precursor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:290970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in trophoblast cell proliferation and differentiation probably by affecting mitotic cell cycle progression. Proteolytic activity and nuclear localization are essential for its role in cell cycle progression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0051301 cell division;GO:0045930 negative regulation of mitotic cell cycle;GO:0051603 proteolysis involved in protein catabolic process;GO:0060707 trophoblast giant cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZ07-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A218-1", "uniprot_id": [ { "id": "DMRT3_RAT", "url": "https://www.uniprot.org/uniprot/D4A218", "type": "external" } ], "mass": 51444.0, "length": 476, "protein_name": "Doublesex and mab-3 related transcription factor 3", "gene_name": "Dmrt3", "organism": "Rat", "refseq_name": "doublesex and mab-3 related transcription factor 3", "refseq_ac": [ { "id": "NP_001099828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099828", "type": "external" } ], "gene_names_uniprotkb": "Dmrt3", "gene_names_refseq": "Dmrt3", "protein_names_uniprotkb": "Doublesex and mab-3 related transcription factor 3", "protein_names_refseq": "doublesex and mab-3 related transcription factor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:293976)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046661 male sex differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A218-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2Z8-1", "uniprot_id": [ { "id": "DHX36_RAT", "url": "https://www.uniprot.org/uniprot/D4A2Z8", "type": "external" } ], "mass": 113843.0, "length": 1000, "protein_name": "ATP-dependent DNA/RNA helicase DHX36", "gene_name": "Dhx36", "organism": "Rat", "refseq_name": "ATP-dependent DNA/RNA helicase DHX36", "refseq_ac": [ { "id": "NP_001101148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101148", "type": "external" } ], "gene_names_uniprotkb": "Dhx36", "gene_names_refseq": "Dhx36; G4R1", "protein_names_uniprotkb": "ATP-dependent DNA/RNA helicase DHX36; 3.6.4.12; 3.6.4.13; DEAD/H box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; G4R1; MLE-like protein 1; RNA helicase associated with AU-rich element protein", "protein_names_refseq": "ATP-dependent DNA/RNA helicase DHX36; DEAD/H box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; MLE-like protein 1; RNA helicase associated with AU-rich element protein; probable ATP-dependent RNA helicase DHX36", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:310461); (R-RNO-3134963)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23651854;29393594", "class_list": "", "function": "Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures (By similarity). Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses (PubMed:23651854). G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-DNA and G4-RNA) (By similarity). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription (By similarity). Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression (By similarity). Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage (By similarity). Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (PubMed:23651854). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (PubMed:23651854). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Also binds to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Required for the early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0032727 positive regulation of interferon-alpha production;GO:2000767 positive regulation of cytoplasmic translation;GO:0051891 positive regulation of cardioblast differentiation;GO:1904582 positive regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A2Z8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4T9-1", "uniprot_id": [ { "id": "CHRD1_RAT", "url": "https://www.uniprot.org/uniprot/D4A4T9", "type": "external" } ], "mass": 37362.0, "length": 331, "protein_name": "Cysteine and histidine-rich domain-containing protein 1", "gene_name": "Chordc1", "organism": "Rat", "refseq_name": "cysteine and histidine-rich domain-containing protein 1", "refseq_ac": [ { "id": "NP_001101598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101598", "type": "external" } ], "gene_names_uniprotkb": "Chordc1", "gene_names_refseq": "CHP-1; Chordc1", "protein_names_uniprotkb": "Cysteine and histidine-rich domain-containing protein 1; CHORD domain-containing protein 1; CHP-1; Morgana", "protein_names_refseq": "CHORD domain-containing protein 1; cysteine and histidine-rich domain (CHORD)-containing 1; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1; cysteine and histidine-rich domain-containing protein 1; morgana", "tax_id": 10116, "disease": "chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:315447)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response. Prevents tumorigenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0043531 ADP binding;GO:0051879 Hsp90 protein binding;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:1900034 regulation of cellular response to heat;GO:0006457 protein folding;GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4T9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8G7-1", "uniprot_id": [ { "id": "D4A8G7_RAT", "url": "https://www.uniprot.org/uniprot/D4A8G7", "type": "external" } ], "mass": 68026.0, "length": 594, "protein_name": "SNW domain-containing protein 1", "gene_name": "Snw1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snw1", "gene_names_refseq": "", "protein_names_uniprotkb": "SNW domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:500695)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;35818332", "class_list": "", "function": "Involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0005112 Notch binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A8G7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AD02-1", "uniprot_id": [ { "id": "CLC9A_RAT", "url": "https://www.uniprot.org/uniprot/D4AD02", "type": "external" } ], "mass": 27429.0, "length": 241, "protein_name": "C-type lectin domain family 9 member A", "gene_name": "Clec9a", "organism": "Rat", "refseq_name": "C-type lectin domain family 9 member A", "refseq_ac": [ { "id": "NP_001102824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102824", "type": "external" } ], "gene_names_uniprotkb": "Clec9a", "gene_names_refseq": "Clec9a; RGD1562513", "protein_names_uniprotkb": "C-type lectin domain family 9 member A", "protein_names_refseq": "C-type lectin domain family 9 member A; C-type lectin domain family 9, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:502901)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20544345", "class_list": "", "function": "Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D9Z4I7", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AD02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AEC2-1", "uniprot_id": [ { "id": "CAMP2_RAT", "url": "https://www.uniprot.org/uniprot/D4AEC2", "type": "external" } ], "mass": 165612.0, "length": 1470, "protein_name": "Calmodulin-regulated spectrin-associated protein 2", "gene_name": "Camsap2", "organism": "Rat", "refseq_name": "calmodulin-regulated spectrin-associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001127975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127975", "type": "external" } ], "gene_names_uniprotkb": "Camsap2", "gene_names_refseq": "Camsap1l1; Camsap2; RGD1310950", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 2", "protein_names_refseq": "calmodulin regulated spectrin-associated protein 1-like 1; calmodulin-regulated spectrin-associated protein 2 isoform 1; calmodulin-regulated spectrin-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:289400)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;24908486;30994903", "class_list": "", "function": "In summary, CAMSAP2 is a regulator of microtubule and actin dynamics in Sertoli cells to support blood-testis barrier dynamics and spermatogenesis., [RefSeq, PubMed]; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:24908486). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also reduces the velocity of microtubule polymerization (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (By similarity). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K7K9", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0036064 ciliary basal body;GO:0036449 microtubule minus-end", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0061564 axon development;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4AEC2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54939-1", "uniprot_id": [ { "id": "DHB3_RAT", "url": "https://www.uniprot.org/uniprot/O54939", "type": "external" } ], "mass": 34223.0, "length": 306, "protein_name": "17-beta-hydroxysteroid dehydrogenase type 3", "gene_name": "Hsd17b3", "organism": "Rat", "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 3", "refseq_ac": [ { "id": "NP_446459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446459", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b3; Edh17b3", "gene_names_refseq": "Hsd17b3", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 3; 1.1.1.62; 1.1.1.64; 17-beta-HSD 3; Estradiol 17-beta-dehydrogenase 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3", "protein_names_refseq": "17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; 17beta-HSD; estradiol 17 beta-dehydrogenase 3; estradiol 17-beta-dehydrogenase 2; testicular 17-beta-hydroxysteroid dehydrogenase; testosterone 17-beta-dehydrogenase 3", "tax_id": 10116, "disease": "17-beta hydroxysteroid dehydrogenase 3 deficiency (Disease Ontology:DOID:0112248); Alzheimer's disease (Disease Ontology:DOID:10652); disorder of sexual development (Disease Ontology:DOID:1923); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:117182); (R-RNO-193048); (R-RNO-75876)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21440566", "class_list": "", "function": "11beta-HSD1 is enzymatically coupled to 17beta-HSD3, [RefSeq, PubMed]; Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function (By similarity). Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting-step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.3.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.3", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0047045 testosterone dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0010288 response to lead ion;GO:0045471 response to ethanol;GO:0021766 hippocampus development;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LPQ2-1", "uniprot_id": [ { "id": "ASCC3_RAT", "url": "https://www.uniprot.org/uniprot/F1LPQ2", "type": "external" } ], "mass": 250220.0, "length": 2197, "protein_name": "Activating signal cointegrator 1 complex subunit 3", "gene_name": "Ascc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ascc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Activating signal cointegrator 1 complex subunit 3; 5.6.2.4", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (R-RNO-9954716)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0022626 cytosolic ribosome;GO:1990391 DNA repair complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006307 DNA alkylation repair;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LPQ2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88671-1", "uniprot_id": [ { "id": "DLL3_RAT", "url": "https://www.uniprot.org/uniprot/O88671", "type": "external" } ], "mass": 61425.0, "length": 589, "protein_name": "Delta-like protein 3", "gene_name": "Dll3", "organism": "Rat", "refseq_name": "delta-like protein 3 precursor", "refseq_ac": [ { "id": "NP_446118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446118", "type": "external" } ], "gene_names_uniprotkb": "Dll3", "gene_names_refseq": "Dll3", "protein_names_uniprotkb": "Delta-like protein 3; Delta3; Drosophila Delta homolog 3", "protein_names_refseq": "delta-like protein 3 precursor; delta-like protein 3; delta3; drosophila Delta homolog 3", "tax_id": 10116, "disease": "spondylocostal dysostosis (Disease Ontology:DOID:0050568); spondylocostal dysostosis 1 (Disease Ontology:DOID:0112365); dysostosis (Disease Ontology:DOID:1934)", "pathway": " (rno:114125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0001501 skeletal system development;GO:0001756 somitogenesis;GO:0050768 negative regulation of neurogenesis;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O88671-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88480-1", "uniprot_id": [ { "id": "CABIN_RAT", "url": "https://www.uniprot.org/uniprot/O88480", "type": "external" } ], "mass": 242813.0, "length": 2182, "protein_name": "Calcineurin-binding protein cabin-1", "gene_name": "Cabin1", "organism": "Rat", "refseq_name": "calcineurin-binding protein cabin-1", "refseq_ac": [ { "id": "NP_446027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446027", "type": "external" } ], "gene_names_uniprotkb": "Cabin1", "gene_names_refseq": "Cabin1; Cain", "protein_names_uniprotkb": "Calcineurin-binding protein cabin-1; CAIN; Calcineurin inhibitor", "protein_names_refseq": "calcineurin inhibitor; calcineurin-binding protein cabin-1-like; calcineurin-binding protein cabin-1", "tax_id": 10116, "disease": "ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (rno:94165); (R-RNO-2559584)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;26400065;29190603;29368245;32000560;9660798", "class_list": "", "function": "Cabin1 involves in renal tubular epithelial cells mitochondrial dysfunction through SIRT1/p53 pathway., [RefSeq, PubMed]; In conclusion, Cabin1 expression significantly increases during podocyte injury. Knockdown of Cabin1 induces p53 expression decrease in cultured podocyte. Cabin1 may provide a new target to investigate podocyte injury., [RefSeq, PubMed]; Injury to renal tubular epithelial cells results in up-regulation of cabin1 expression., [RefSeq, PubMed]; Knocking down Cabin1 induces the disruption of cytoskeleton and mitochondrial dysfunction in podocyte. Cabin1 could be a crucial factor in podocyte damage., [RefSeq, PubMed]; May be required for replication-independent chromatin assembly (By similarity). May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0030346 protein phosphatase 2B binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000417 HIR complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0014823 response to activity;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88480-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35831-1", "uniprot_id": [ { "id": "CDK17_RAT", "url": "https://www.uniprot.org/uniprot/O35831", "type": "external" } ], "mass": 59432.0, "length": 523, "protein_name": "Cyclin-dependent kinase 17", "gene_name": "Cdk17", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk17; Pctaire2; Pctk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 17; 2.7.11.22; Cell division protein kinase 17; PCTAIRE-motif protein kinase 2; Serine/threonine-protein kinase PCTAIRE-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:314743)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10727952;16641100;22673903;9370357", "class_list": "", "function": "May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1901987 regulation of cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88501-1", "uniprot_id": [ { "id": "CAN6_RAT", "url": "https://www.uniprot.org/uniprot/O88501", "type": "external" } ], "mass": 74560.0, "length": 641, "protein_name": "Calpain-6", "gene_name": "Capn6", "organism": "Rat", "refseq_name": "calpain-6", "refseq_ac": [ { "id": "NP_113996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113996", "type": "external" } ], "gene_names_uniprotkb": "Capn6; Capa6", "gene_names_refseq": "Capn6", "protein_names_uniprotkb": "Calpain-6", "protein_names_refseq": "calpain-6", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:83685); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0004198 calcium-dependent cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0005876 spindle microtubule", "go_biological_process": "GO:0051493 regulation of cytoskeleton organization;GO:0001578 microtubule bundle formation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O88501-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35783-1", "uniprot_id": [ { "id": "CALU_RAT", "url": "https://www.uniprot.org/uniprot/O35783", "type": "external" } ], "mass": 36997.0, "length": 315, "protein_name": "Calumenin", "gene_name": "Calu", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Calu", "gene_names_refseq": "", "protein_names_uniprotkb": "Calumenin; CBP-50; Crocalbin", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (rno:64366)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10094503;15075329;22673903", "class_list": "", "function": "Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens. This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0014012 peripheral nervous system axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35783-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55197-1", "uniprot_id": [ { "id": "C3AR_RAT", "url": "https://www.uniprot.org/uniprot/O55197", "type": "external" } ], "mass": 52896.0, "length": 473, "protein_name": "C3a anaphylatoxin chemotactic receptor", "gene_name": "C3ar1", "organism": "Rat", "refseq_name": "C3a anaphylatoxin chemotactic receptor", "refseq_ac": [ { "id": "NP_114449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114449", "type": "external" } ], "gene_names_uniprotkb": "C3ar1", "gene_names_refseq": "C3ar1", "protein_names_uniprotkb": "C3a anaphylatoxin chemotactic receptor; C3AR; C3a-R", "protein_names_refseq": "C3AR; C3a anaphylatoxin chemotactic receptor; C3a-R; complement component 3a receptor 1", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:84007); (R-RNO-375276); (R-RNO-418594); (R-RNO-6798695); (R-RNO-977606)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "23713944;23940034;25422985;32617860;36871753;9464274", "class_list": "", "function": "C3aR in astrocytes mediates post-thoracotomy pain by inducing A1 astrocytes in male rats., [RefSeq, PubMed]; C3aRA ameliorated T2DN by inhibiting IKBalpha phosphorylation and cytokine release, and also TGF-beta/Smad3 signaling and ECM deposition Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11. Erratum:[Inflammation. 2021 Jun;44(3):1203-1204. doi: 10.1007/s10753-020-01380-0. PMID: 33174140], [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats., [RefSeq, PubMed]; The binding of TLQP-21 to C3AR1 not only has effects on signaling but also modulates cellular functions, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001850 complement component C3a binding;GO:0004876 complement component C3a receptor activity;GO:0004878 complement component C5a receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0002430 complement receptor mediated signaling pathway;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55197-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35854-1", "uniprot_id": [ { "id": "BCAT2_RAT", "url": "https://www.uniprot.org/uniprot/O35854", "type": "external" } ], "mass": 44276.0, "length": 393, "protein_name": "Branched-chain-amino-acid aminotransferase, mitochondrial", "gene_name": "Bcat2", "organism": "Rat", "refseq_name": "branched-chain-amino-acid aminotransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_071795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071795", "type": "external" } ], "gene_names_uniprotkb": "Bcat2; Bcatm; Eca40", "gene_names_refseq": "BCT2; Bcat2; Bcatm; mBcat", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, mitochondrial; 2.6.1.42; BCAT(m)", "protein_names_refseq": "BCAT(m); branched chain amino acid transaminase 2, mitochondrial; branched chain aminotransferase 2, mitochondrial; branched-chain-amino-acid aminotransferase, mitochondrial precursor; branched-chain-amino-acid aminotransferase, mitochondrial; heart branched chain aminotransferase precursor encoding mitochondrial protein", "tax_id": 10116, "disease": "hypervalinemia and hyperleucine-isoleucinemia (Disease Ontology:DOID:0060950); amino acid metabolic disorder (Disease Ontology:DOID:9252); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (rno:64203); (R-RNO-70895)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "19858196;22673903;27488662;31833233;8381418;8428987;9165094", "class_list": "", "function": "Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes. Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning. May also function as a transporter of branched chain alpha-keto acids., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation., [RefSeq, PubMed]; GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate., [RefSeq, PubMed]; The effect of KIC on insulin-stimulated glucose transport was abrogated in cells depleted of branched-chain aminotransferase 2 (BCAT2)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0050873 brown fat cell differentiation;GO:0097009 energy homeostasis;GO:1990830 cellular response to leukemia inhibitory factor;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35854-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Y7-1", "uniprot_id": [ { "id": "AP4AT_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Y7", "type": "external" } ], "mass": 60281.0, "length": 569, "protein_name": "AP-4 complex accessory subunit Tepsin", "gene_name": "Tepsin", "organism": "Rat", "refseq_name": "AP-4 complex accessory subunit tepsin", "refseq_ac": [ { "id": "NP_001094199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094199", "type": "external" } ], "gene_names_uniprotkb": "Tepsin; Enthd2", "gene_names_refseq": "Enthd2; RGD1307410; Tepsin", "protein_names_uniprotkb": "AP-4 complex accessory subunit Tepsin; ENTH domain-containing protein 2; Tetra-epsin", "protein_names_refseq": "AP-4 complex accessory subunit tepsin; ENTH domain containing 2; ENTH domain-containing protein 2; tetra-epsin", "tax_id": 10116, "disease": "", "pathway": " (rno:360673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22472443;22673903", "class_list": "", "function": "Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5EB78", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0031090 organelle membrane;GO:0030662 coated vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V8Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V909-1", "uniprot_id": [ { "id": "ATF6A_RAT", "url": "https://www.uniprot.org/uniprot/G3V909", "type": "external" } ], "mass": 72665.0, "length": 656, "protein_name": "Cyclic AMP-dependent transcription factor ATF-6 alpha", "gene_name": "Atf6", "organism": "Rat", "refseq_name": "cyclic AMP-dependent transcription factor ATF-6 alpha", "refseq_ac": [ { "id": "NP_001100666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100666", "type": "external" } ], "gene_names_uniprotkb": "Atf6", "gene_names_refseq": "Atf6", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-6 alpha; ATF6-alpha; Activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha", "protein_names_refseq": "ATF6-alpha; activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 alpha", "tax_id": 10116, "disease": "achromatopsia 7 (Disease Ontology:DOID:0110009); borna disease (Disease Ontology:DOID:5154)", "pathway": " (rno:304962); (R-RNO-381033)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22682248;34816499;36881290;37499993;38613810", "class_list": "", "function": "Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine gamma-lyase expression in a rat model of intracerebral hemorrhage., [RefSeq, PubMed]; CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma., [RefSeq, PubMed]; Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast. Erratum:[Apoptosis. 2023 Oct;28(9-10):1501. doi: 10.1007/s10495-023-01864-y. PMID: 37439923], [RefSeq, PubMed]; MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6., [RefSeq, PubMed]; Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR)., [UniProtKB, UniProtKB]; Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B5DF18", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02665-1", "uniprot_id": [ { "id": "CASB_RAT", "url": "https://www.uniprot.org/uniprot/P02665", "type": "external" } ], "mass": 25369.0, "length": 231, "protein_name": "Beta-casein", "gene_name": "Csn2", "organism": "Rat", "refseq_name": "beta-casein precursor", "refseq_ac": [ { "id": "NP_058816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058816", "type": "external" } ], "gene_names_uniprotkb": "Csn2; Csnb", "gene_names_refseq": "Csn2; Csnb", "protein_names_uniprotkb": "Beta-casein", "protein_names_refseq": "beta-casein precursor; beta-casein", "tax_id": 10116, "disease": "", "pathway": " (rno:29173)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18462607;21621605;3997858;6283475", "class_list": "", "function": "4-Vinylcyclohexene diepoxide administration to 1-month rats acutely decreased mammary alveolar bud number and expression of beta-casein., [RefSeq, PubMed]; Important role in determination of the surface properties of the casein micelles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mammary tissue from late pregnant Restricted rats had elevated alpha-lactalbumin, but not beta-casein mRNA., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02665-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01026-1", "uniprot_id": [ { "id": "CO3_RAT", "url": "https://www.uniprot.org/uniprot/P01026", "type": "external" } ], "mass": 186460.0, "length": 1663, "protein_name": "Complement C3", "gene_name": "C3", "organism": "Rat", "refseq_name": "complement C3 precursor", "refseq_ac": [ { "id": "NP_058690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058690", "type": "external" } ], "gene_names_uniprotkb": "C3", "gene_names_refseq": "C3", "protein_names_uniprotkb": "Complement C3; C3adesArg; Complement C3b-alpha' chain; ENCF-1; ENCF-2; Neutrophil chemotactic factor-1; Neutrophil chemotactic factor-2", "protein_names_refseq": "complement C3 precursor; complement component 3", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); primary autosomal recessive microcephaly 19 (Disease Ontology:DOID:0070281); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); age related macular degeneration 7 (Disease Ontology:DOID:0110019); age related macular degeneration 9 (Disease Ontology:DOID:0110021); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); dry eye syndrome (Disease Ontology:DOID:10140); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); lepromatous leprosy (Disease Ontology:DOID:10887); microcephaly (Disease Ontology:DOID:10907); sickle cell anemia (Disease Ontology:DOID:10923); membranous glomerulonephritis (Disease Ontology:DOID:10976); pneumocystosis (Disease Ontology:DOID:11339); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); factor VIII deficiency (Disease Ontology:DOID:12134); neurodegenerative disease (Disease Ontology:DOID:1289); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); anterior uveitis (Disease Ontology:DOID:1407); boutonneuse fever (Disease Ontology:DOID:14095); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); arteriolosclerosis (Disease Ontology:DOID:5162); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); conjunctivitis (Disease Ontology:DOID:6195); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); complement component 3 deficiency (Disease Ontology:DOID:8354); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24232); (R-RNO-173736); (R-RNO-174577); (R-RNO-198933); (R-RNO-375276); (R-RNO-381426); (R-RNO-418594); (R-RNO-6798695); (R-RNO-8957275); (R-RNO-977606)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "10825534;22673903;2336397;2674144;29393594;309768;32617860;8352775", "class_list": "", "function": "Acts as a chemoattractant for neutrophils in chronic inflammation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial triglyceride clearance. Appears to stimulate triglyceride synthesis via activation of the PLC, MAPK and AKT signaling pathways. Acts by binding to its receptor, C5AR2, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C5AR2. In contrast to C3a anaphylatoxin peptide, does not show pro-inflammatory activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11. Erratum:[Inflammation. 2021 Jun;44(3):1203-1204. doi: 10.1007/s10753-020-01380-0. PMID: 33174140], [RefSeq, PubMed]; Mediator of local inflammatory process released following cleavage by C3 convertase (By similarity). Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1 (By similarity). C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development (By similarity). Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants (PubMed:8352775)., [UniProtKB, PubMed, UniProtKB]; Mediator of local inflammatory process released following cleavage by C3 convertase. Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1. C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development. Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants., [UniProtKB, UniProtKB, UniProtKB]; Non-enzymatic component of C5 convertase. Generated following cleavage by C3 convertase, it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. Complement C3b binds covalently via its reactive thioester, to cell surface carbohydrates or immune aggregates. Together with complement C4b, it then recruits the serine protease complement C2b to form the C5 convertase, which cleaves and activate C5, the next component of the complement pathways. In the alternative complement pathway, recruits the serine protease CFB to form the C5 convertase that cleaves and activates C5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 62, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9ET19;Q9QV57;Q9QV58", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0008289 lipid binding;GO:0048018 receptor ligand activity;GO:0003823 antigen binding;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0032991 protein-containing complex;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0060384 innervation;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0002430 complement receptor mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P01026-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08556-1", "uniprot_id": [ { "id": "CCR5_RAT", "url": "https://www.uniprot.org/uniprot/O08556", "type": "external" } ], "mass": 41031.0, "length": 354, "protein_name": "C-C chemokine receptor type 5", "gene_name": "Ccr5", "organism": "Rat", "refseq_name": "C-C chemokine receptor type 5", "refseq_ac": [ { "id": "NP_446412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446412", "type": "external" } ], "gene_names_uniprotkb": "Ccr5; Cmkbr5", "gene_names_refseq": "Ccr5; Ckr5; Cmkbr5", "protein_names_uniprotkb": "C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; MIP-1 alpha receptor", "protein_names_refseq": "C-C CKR-5; C-C chemokine receptor type 5; CC-CKR-5; MIP-1 alpha receptor; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5", "tax_id": 10116, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599); type 1 diabetes mellitus 22 (Disease Ontology:DOID:0110759); dry eye syndrome (Disease Ontology:DOID:10140); berylliosis (Disease Ontology:DOID:10322); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sarcoidosis (Disease Ontology:DOID:11335); optic neuritis (Disease Ontology:DOID:1210); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); posterior uveitis (Disease Ontology:DOID:12574); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); anterior uveitis (Disease Ontology:DOID:1407); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); hepatitis C (Disease Ontology:DOID:1883); fallopian tube disease (Disease Ontology:DOID:1962); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); West Nile fever (Disease Ontology:DOID:2366); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); allergic contact dermatitis (Disease Ontology:DOID:3042); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); plague (Disease Ontology:DOID:3482); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); syphilis (Disease Ontology:DOID:4166); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893); leishmaniasis (Disease Ontology:DOID:9065); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:117029); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "31574524;32446198;34774582;34843718;9655467;9670989", "class_list": "", "function": "CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1., [RefSeq, PubMed]; CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia., [RefSeq, PubMed]; NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages., [RefSeq, PubMed]; R5 HIV-1 gp120 activated p38 MAPK to trigger myocardial cell injury by the CCR5 coreceptor., [RefSeq, PubMed]; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 53, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0016493 C-C chemokine receptor activity;GO:0019901 protein kinase binding;GO:0019957 C-C chemokine binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08556-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09027-1", "uniprot_id": [ { "id": "ACKR2_RAT", "url": "https://www.uniprot.org/uniprot/O09027", "type": "external" } ], "mass": 43293.0, "length": 382, "protein_name": "Atypical chemokine receptor 2", "gene_name": "Ackr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ackr2; Ccbp2; Ccr10rr; D6", "gene_names_refseq": "", "protein_names_uniprotkb": "Atypical chemokine receptor 2; C-C chemokine receptor D6; CCR10-related receptor; Chemokine-binding protein 2; Chemokine-binding protein D6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:140473); (R-RNO-380108)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;9324304", "class_list": "", "function": "Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007165 signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O09027-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35186-1", "uniprot_id": [ { "id": "CATK_RAT", "url": "https://www.uniprot.org/uniprot/O35186", "type": "external" } ], "mass": 36791.0, "length": 329, "protein_name": "Cathepsin K", "gene_name": "Ctsk", "organism": "Rat", "refseq_name": "cathepsin K precursor", "refseq_ac": [ { "id": "NP_113748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113748", "type": "external" } ], "gene_names_uniprotkb": "Ctsk", "gene_names_refseq": "Ctsk", "protein_names_uniprotkb": "Cathepsin K; 3.4.22.38", "protein_names_refseq": "cathepsin K precursor", "tax_id": 10116, "disease": "pycnodysostosis (Disease Ontology:DOID:0080038); otitis media (Disease Ontology:DOID:10754); intracranial aneurysm (Disease Ontology:DOID:10941)", "pathway": " (rno:29175); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-1679131); (R-RNO-2132295); (R-RNO-8939242)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "14585819;25558848;29207029", "class_list": "", "function": "Cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies, [RefSeq, PubMed]; Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model., [RefSeq, PubMed]; The present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin, [RefSeq, PubMed]; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" } ], "go_molecular_function": "GO:0005518 collagen binding;GO:0008233 peptidase activity;GO:0043394 proteoglycan binding;GO:0001968 fibronectin binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0045471 response to ethanol;GO:0032868 response to insulin;GO:0045453 bone resorption;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35186-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35920-1", "uniprot_id": [ { "id": "CAN9_RAT", "url": "https://www.uniprot.org/uniprot/O35920", "type": "external" } ], "mass": 79263.0, "length": 690, "protein_name": "Calpain-9", "gene_name": "Capn9", "organism": "Rat", "refseq_name": "calpain-9", "refseq_ac": [ { "id": "NP_001258069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258069", "type": "external" } ], "gene_names_uniprotkb": "Capn9; Ncl4", "gene_names_refseq": "Capn9; Ncl-4", "protein_names_uniprotkb": "Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; nCL-4", "protein_names_refseq": "calpain-9; digestive tract-specific calpain; new calpain 4", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116694); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15665521;9524069", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB]; Differential regulation of calpain 9 may play a role in hypertensive target organ damage, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LR50", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54783-1", "uniprot_id": [ { "id": "CHKB_RAT", "url": "https://www.uniprot.org/uniprot/O54783", "type": "external" } ], "mass": 45100.0, "length": 394, "protein_name": "Choline/ethanolamine kinase", "gene_name": "Chkb", "organism": "Rat", "refseq_name": "choline/ethanolamine kinase", "refseq_ac": [ { "id": "NP_058873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058873", "type": "external" } ], "gene_names_uniprotkb": "Chkb; Chetk; Chkl", "gene_names_refseq": "Chetk; Chkb; Chkl", "protein_names_uniprotkb": "Choline/ethanolamine kinase; 2.7.1.32; 2.7.1.82; CKB; CKEKB; CK; Choline kinase beta; EK; Ethanolamine kinase; choline/ethanolamine kinase beta", "protein_names_refseq": "CKB; CKEKB; EK; choline/ethanolamine kinase beta; choline/ethanolamine kinase", "tax_id": 10116, "disease": "megaconial type congenital muscular dystrophy (Disease Ontology:DOID:0110632); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); epilepsy (Disease Ontology:DOID:1826); recurrent hypersomnia (Disease Ontology:DOID:8619); narcolepsy (Disease Ontology:DOID:8986); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:29367); (R-RNO-1483191); (R-RNO-1483213)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9487136", "class_list": "", "function": "Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004103 choline kinase activity;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0006656 phosphatidylcholine biosynthetic process;GO:0007517 muscle organ development;GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54783-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70352-1", "uniprot_id": [ { "id": "CD82_RAT", "url": "https://www.uniprot.org/uniprot/O70352", "type": "external" } ], "mass": 29487.0, "length": 266, "protein_name": "CD82 antigen", "gene_name": "Cd82", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd82; Kai1", "gene_names_refseq": "", "protein_names_uniprotkb": "CD82 antigen; Metastasis suppressor Kangai-1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (rno:83628)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24090084;9831222", "class_list": "", "function": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity). Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (By similarity). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (By similarity). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (By similarity). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70352-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70454-1", "uniprot_id": [ { "id": "BUD31_RAT", "url": "https://www.uniprot.org/uniprot/O70454", "type": "external" } ], "mass": 17000.0, "length": 144, "protein_name": "Protein BUD31 homolog", "gene_name": "Bud31", "organism": "Rat", "refseq_name": "protein BUD31 homolog", "refseq_ac": [ { "id": "NP_446008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446008", "type": "external" } ], "gene_names_uniprotkb": "Bud31; Edg2; G10", "gene_names_refseq": "Bud31; Edg2; G10; LPA1", "protein_names_uniprotkb": "Protein BUD31 homolog; Protein EDG-2; Protein G10 homolog", "protein_names_refseq": "BUD31 homolog; EDG-2; maternal G10 transcript; protein BUD31 homolog; protein EDG-2; protein G10 homolog", "tax_id": 10116, "disease": "schistosomiasis (Disease Ontology:DOID:1395)", "pathway": " (rno:89819); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDW3", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0000785 chromatin;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O70454-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88181-1", "uniprot_id": [ { "id": "BARH2_RAT", "url": "https://www.uniprot.org/uniprot/O88181", "type": "external" } ], "mass": 41463.0, "length": 384, "protein_name": "BarH-like 2 homeobox protein", "gene_name": "Barhl2", "organism": "Rat", "refseq_name": "barH-like 2 homeobox protein", "refseq_ac": [ { "id": "NP_075245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075245", "type": "external" } ], "gene_names_uniprotkb": "Barhl2; Mbh1", "gene_names_refseq": "Barhl2; Barh; MBH1", "protein_names_uniprotkb": "BarH-like 2 homeobox protein; Bar-class homeodomain protein MBH1; Homeobox protein B-H1", "protein_names_refseq": "BarH-class homeodomain transcription factor; bar-class homeodomain protein MBH1; barH-like 2 homeobox protein; homeobox protein B-H1", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:65050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9698441", "class_list": "", "function": "Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up-regulate NGN2, thereby regulating distinct patterns of neuronal differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88181-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88514-1", "uniprot_id": [ { "id": "DEFB4_RAT", "url": "https://www.uniprot.org/uniprot/O88514", "type": "external" } ], "mass": 6946.0, "length": 63, "protein_name": "Beta-defensin 4", "gene_name": "Defb4", "organism": "Rat", "refseq_name": "beta-defensin 4 precursor", "refseq_ac": [ { "id": "NP_071989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071989", "type": "external" } ], "gene_names_uniprotkb": "Defb4; Defb2; Defb3", "gene_names_refseq": "Defb2; Defb3; Defb4", "protein_names_uniprotkb": "Beta-defensin 4; BD-2; BD-4; Defensin, beta 4; RBD-2; RBD-4", "protein_names_refseq": "BD-2; BD-4; RBD-2; RBD-4; beta defensin-2; beta-defensin 3; beta-defensin 4 precursor; beta-defensin 4; defensin beta 3", "tax_id": 10116, "disease": "common cold (Disease Ontology:DOID:10459); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cystic fibrosis (Disease Ontology:DOID:1485); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (rno:64389)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10456937;16033865;20150208;21518253", "class_list": "", "function": "Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation, [RefSeq, PubMed]; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells., [UniProtKB, UniProtKB]; HMGN2 acts as a positive modulator of nuclear factor kappaB signalling to promote lipopolysaccharide-induced beta-defensin-2 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32ZE9", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88514-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88677-1", "uniprot_id": [ { "id": "BTG3_RAT", "url": "https://www.uniprot.org/uniprot/O88677", "type": "external" } ], "mass": 28914.0, "length": 252, "protein_name": "Protein BTG3", "gene_name": "Btg3", "organism": "Rat", "refseq_name": "protein BTG3", "refseq_ac": [ { "id": "NP_062163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062163", "type": "external" } ], "gene_names_uniprotkb": "Btg3", "gene_names_refseq": "Btg3", "protein_names_uniprotkb": "Protein BTG3; BTG family member 3; rBTG3", "protein_names_refseq": "B-cell translocation gene 3; BTG family, member 3; protein BTG3; rBTG3", "tax_id": 10116, "disease": "congenital myasthenic syndrome 5 (Disease Ontology:DOID:0110667)", "pathway": " (rno:54230)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10564823;16434477;19359386;23770100", "class_list": "", "function": "BTG3, a novel, direct target of miR-142-5p, negatively regulates VSMC proliferation, [RefSeq, PubMed]; By controlling the basal threshold of Src activity, constitutes an important negative regulatory mechanism for Src-mediated signalling., [RefSeq, PubMed]; Fndings suggest that the induction of the Btg3 may be important for theca and granulosa cell differentiation into luteal cells by arresting cell cycle progression., [RefSeq, PubMed]; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008285 negative regulation of cell population proliferation;GO:0045930 negative regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88677-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88813-1", "uniprot_id": [ { "id": "ACSL5_RAT", "url": "https://www.uniprot.org/uniprot/O88813", "type": "external" } ], "mass": 76405.0, "length": 683, "protein_name": "Long-chain-fatty-acid--CoA ligase 5", "gene_name": "Acsl5", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase 5", "refseq_ac": [ { "id": "NP_446059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446059", "type": "external" } ], "gene_names_uniprotkb": "Acsl5; Acs5; Facl5", "gene_names_refseq": "Acs5; Acsl5; Facl5", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 5; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 5; Long-chain acyl-CoA synthetase 5", "protein_names_refseq": "LACS 5; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; long-chain-fatty-acid--CoA ligase 5", "tax_id": 10116, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (rno:94340); (R-RNO-75876)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15683247;16263710;17761945;20798351;22171129;28209804;9722683", "class_list": "", "function": "ACSL5 activates and channels fatty acids toward anabolic pathways, [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity;GO:0090434 oleoyl-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0032869 cellular response to insulin stimulus;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00507-1", "uniprot_id": [ { "id": "AATM_RAT", "url": "https://www.uniprot.org/uniprot/P00507", "type": "external" } ], "mass": 47314.0, "length": 430, "protein_name": "Aspartate aminotransferase, mitochondrial", "gene_name": "Got2", "organism": "Rat", "refseq_name": "aspartate aminotransferase, mitochondrial", "refseq_ac": [ { "id": "NP_037309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037309", "type": "external" } ], "gene_names_uniprotkb": "Got2; Maat", "gene_names_refseq": "ASPATA; Got2; mAAT", "protein_names_uniprotkb": "Aspartate aminotransferase, mitochondrial; 2.6.1.1; 2.6.1.7; FABP-1; FABPpm; Fatty acid-binding protein; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; Transaminase A; mAspAT", "protein_names_refseq": "FABP-1; FABPpm; Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2); aspartate aminotransferase, mitochondrial; fatty acid-binding protein; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; mAspAT; plasma membrane-associated fatty acid-binding protein; transaminase A", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 82 (Disease Ontology:DOID:0080715); neurodegenerative disease (Disease Ontology:DOID:1289); acute kidney failure (Disease Ontology:DOID:3021); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25721); (R-RNO-389661); (R-RNO-8963693); (R-RNO-8964539); (R-RNO-9856872)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "11962739;17442055;18683930;26446791;27213235;3004464;31473978;3322287;34502162;38053021;7309704;7470110;7759512;8238519", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Changes in glutamic oxaloacetic transaminase 2 during rat physiological and pathological cardiomyocyte hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64551;Q9QV50", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0019899 enzyme binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0043648 dicarboxylic acid metabolic process;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P00507-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00787-1", "uniprot_id": [ { "id": "CATB_RAT", "url": "https://www.uniprot.org/uniprot/P00787", "type": "external" } ], "mass": 37470.0, "length": 339, "protein_name": "Cathepsin B", "gene_name": "Ctsb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctsb", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathepsin B; 3.4.22.1; Cathepsin B1; RSG-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); polycystic kidney disease (Disease Ontology:DOID:0080322); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); otitis media (Disease Ontology:DOID:10754); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); Guillain-Barre syndrome (Disease Ontology:DOID:12842); renal tubular acidosis (Disease Ontology:DOID:14219); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); brain infarction (Disease Ontology:DOID:3454); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); fascioliasis (Disease Ontology:DOID:885); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:64529); (R-RNO-1442490); (R-RNO-1679131); (R-RNO-2022090); (R-RNO-2132295); (R-RNO-6798695); (R-RNO-9766229); (R-RNO-9958810)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "1639824;2986112;38843836;6574504;7890671;8001549;8740363", "class_list": "", "function": "Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:1639824). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0005518 collagen binding;GO:0044877 protein-containing complex binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0030855 epithelial cell differentiation;GO:0045471 response to ethanol;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00787-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01355-1", "uniprot_id": [ { "id": "CCKN_RAT", "url": "https://www.uniprot.org/uniprot/P01355", "type": "external" } ], "mass": 12841.0, "length": 115, "protein_name": "Cholecystokinin", "gene_name": "Cck", "organism": "Rat", "refseq_name": "cholecystokinin preproprotein", "refseq_ac": [ { "id": "NP_036961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036961", "type": "external" } ], "gene_names_uniprotkb": "Cck", "gene_names_refseq": "Cck", "protein_names_uniprotkb": "Cholecystokinin; CCK", "protein_names_refseq": "cholecystokinin preproprotein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); morbid obesity (Disease Ontology:DOID:11981); epilepsy (Disease Ontology:DOID:1826); acute pancreatitis (Disease Ontology:DOID:2913); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); alcoholic pancreatitis (Disease Ontology:DOID:4988); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25298); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12479974;28466358;28684275;29339381;2981840;31012948;33422646;3861130;6199787;6209267;8208365", "class_list": "", "function": "Results show that cholecystokinin promotes lipid storage in white adipose tissue by acting on adipocyte cholecystokinin-2 receptor, [RefSeq, PubMed]; Study provides the first direct comparative and quantitative data showing that presynaptic GABAB receptors exert differential inhibition at cholecystokinin (CCK) and parvalbumin (PV) basket cell (BC) synapses, resulting from a higher surface expression of the receptor at all CCK BC terminals and a lower protein density present in a subpopulation of boutons of PV BCs., [RefSeq, PubMed]; The cholecystokinin receptor agonist, CCK-8, induces adiponectin production in rat white adipose tissue., [RefSeq, PubMed]; The critical role of CCK in the regulation of food intake and diet-induced obesity. Review article, [RefSeq, PubMed]; The two projections from CCK(NTS) neurons reduce food intake through opposite motivational states; one pathway signals positive valence (CCK(NTS)-->paraventricular nucleus of the hypothalamus ) and the other signals negative valence (CCK(NTS)-->parabrachial nucleus)., [RefSeq, PubMed]; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007409 axonogenesis;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01355-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02661-1", "uniprot_id": [ { "id": "CASA1_RAT", "url": "https://www.uniprot.org/uniprot/P02661", "type": "external" } ], "mass": 31802.0, "length": 284, "protein_name": "Alpha-S1-casein", "gene_name": "Csn1s1", "organism": "Rat", "refseq_name": "alpha-S1-casein precursor", "refseq_ac": [ { "id": "NP_620229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620229", "type": "external" } ], "gene_names_uniprotkb": "Csn1s1; Csna", "gene_names_refseq": "Casa; Csn1s1; Csn1; Csna", "protein_names_uniprotkb": "Alpha-S1-casein; Alpha-casein", "protein_names_refseq": "Casein, alpha; alpha-S1-casein precursor; alpha-S1-casein; alpha-casein", "tax_id": 10116, "disease": "", "pathway": " (rno:24284); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20704729;22673903;3952000;6298707", "class_list": "", "function": "Important role in the capacity of milk to transport calcium phosphate., [UniProtKB]; Present in a membrane-associated form in the endoplasmic reticulum and in more distal compartments of the secretory pathway of mammary epithelial cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0032570 response to progesterone;GO:0032355 response to estradiol;GO:1903494 response to dehydroepiandrosterone;GO:1903496 response to 11-deoxycorticosterone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02661-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02706-1", "uniprot_id": [ { "id": "ASGR1_RAT", "url": "https://www.uniprot.org/uniprot/P02706", "type": "external" } ], "mass": 32849.0, "length": 284, "protein_name": "Asialoglycoprotein receptor 1", "gene_name": "Asgr1", "organism": "Rat", "refseq_name": "asialoglycoprotein receptor 1 isoform a", "refseq_ac": [ { "id": "NP_036635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036635", "type": "external" } ], "gene_names_uniprotkb": "Asgr1; Asgr-1", "gene_names_refseq": "ASGR; Asgr1; RATRHL1; RHL1", "protein_names_uniprotkb": "Asialoglycoprotein receptor 1; ASGP-R 1; ASGPR 1; HL-1; Hepatic lectin 1; rHL-1", "protein_names_refseq": "ASGP-R 1; ASGPR 1; Asialoglycoprotein receptor 1 (hepatic lectin); HL-1; RHL-1; asialoglycoprotein receptor (RHL1); asialoglycoprotein receptor 1 isoform a; hepatic lectin 1, RHL1", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); pancreatitis (Disease Ontology:DOID:4989); cocaine abuse (Disease Ontology:DOID:809); arthritis (Disease Ontology:DOID:848); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24210); (R-RNO-446203)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12949020;16286643;2945599;2995379;34131415;6095287;8943311", "class_list": "", "function": "A correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content., [RefSeq, PubMed]; Asialoglycoprotein Receptor-Targeted Superparamagnetic Perfluorooctylbromide Nanoparticles. Publication Status: Online-Only, [RefSeq, PubMed]; Asialoglycoprotein receptor functions to help regulate the concentration of glycoproteins bearing sialic acid alpha 2,6GalNAc in the blood., [RefSeq, PubMed]; Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis. Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway. Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (By similarity). May also play a physiological role in the regulatory network of lipid homeostasis (By similarity). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005537 D-mannose binding;GO:0042806 fucose binding;GO:0004873 asialoglycoprotein receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P02706-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04468-1", "uniprot_id": [ { "id": "CASK_RAT", "url": "https://www.uniprot.org/uniprot/P04468", "type": "external" } ], "mass": 19548.0, "length": 178, "protein_name": "Kappa-casein", "gene_name": "Csn3", "organism": "Rat", "refseq_name": "kappa-casein precursor", "refseq_ac": [ { "id": "NP_113750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113750", "type": "external" } ], "gene_names_uniprotkb": "Csn3; Csn10; Csnk", "gene_names_refseq": "Csn10; Csn3; Csnk", "protein_names_uniprotkb": "Kappa-casein", "protein_names_refseq": "Csn 10; kappa-casein precursor; kappa-casein", "tax_id": 10116, "disease": "", "pathway": " (rno:29188); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "6094580", "class_list": "", "function": "Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050821 protein stabilization;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04468-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04638-1", "uniprot_id": [ { "id": "APOA2_RAT", "url": "https://www.uniprot.org/uniprot/P04638", "type": "external" } ], "mass": 11439.0, "length": 102, "protein_name": "Apolipoprotein A-II", "gene_name": "Apoa2", "organism": "Rat", "refseq_name": "apolipoprotein A-II preproprotein", "refseq_ac": [ { "id": "NP_037244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037244", "type": "external" } ], "gene_names_uniprotkb": "Apoa2", "gene_names_refseq": "APOAII; Apo-AII; ApoA-II; Apoa2", "protein_names_uniprotkb": "Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2", "protein_names_refseq": "apolipoprotein A-II preproprotein; apolipoprotein A-II", "tax_id": 10116, "disease": "familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25649); (R-RNO-381426); (R-RNO-8957275); (R-RNO-8963888); (R-RNO-8963901); (R-RNO-975634)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "3084795;3093619", "class_list": "", "function": "May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0009395 phospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04638-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04639-1", "uniprot_id": [ { "id": "APOA1_RAT", "url": "https://www.uniprot.org/uniprot/P04639", "type": "external" } ], "mass": 30062.0, "length": 259, "protein_name": "Apolipoprotein A-I", "gene_name": "Apoa1", "organism": "Rat", "refseq_name": "apolipoprotein A-I preproprotein", "refseq_ac": [ { "id": "NP_036870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036870", "type": "external" } ], "gene_names_uniprotkb": "Apoa1", "gene_names_refseq": "Apoa1; apoA-I", "protein_names_uniprotkb": "Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1", "protein_names_refseq": "apo-AI; apolipoprotein A-1; apolipoprotein A-I preproprotein; apolipoprotein A-I; preproapolipoprotein A-I", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); primary hypoalphalipoproteinemia 2 (Disease Ontology:DOID:0080958); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Budd-Chiari syndrome (Disease Ontology:DOID:11512); nephrotic syndrome (Disease Ontology:DOID:1184); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypolipoproteinemia (Disease Ontology:DOID:1387); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); coronary artery disease (Disease Ontology:DOID:3393); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); systemic lupus erythematosus (Disease Ontology:DOID:9074); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25081); (R-RNO-114608); (R-RNO-1369062); (R-RNO-2168880); (R-RNO-3000471); (R-RNO-3000480); (R-RNO-381426); (R-RNO-8957275); (R-RNO-8963888); (R-RNO-8963896); (R-RNO-8963901); (R-RNO-8964011); (R-RNO-8964058); (R-RNO-9707616); (R-RNO-975634)", "pathway_count": 15, "publication_count": 5, "publication_id_list": "29581158;3020028;6426956;6798036;9415807", "class_list": "", "function": "C-terminal truncation of apoA-I by chymase released from cardiac mast cells during ischemia impairs the ability of apoA-I to heal damaged endothelium in the ischemic myocardium, [RefSeq, PubMed]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08877;O09054;Q5EBB2", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005319 lipid transporter activity;GO:0005543 phospholipid binding;GO:0019899 enzyme binding;GO:0034191 apolipoprotein A-I receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0034363 intermediate-density lipoprotein particle;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P04639-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04762-1", "uniprot_id": [ { "id": "CATA_RAT", "url": "https://www.uniprot.org/uniprot/P04762", "type": "external" } ], "mass": 59757.0, "length": 527, "protein_name": "Catalase", "gene_name": "Cat", "organism": "Rat", "refseq_name": "catalase", "refseq_ac": [ { "id": "NP_036652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036652", "type": "external" } ], "gene_names_uniprotkb": "Cat; Cas1", "gene_names_refseq": "CS1; Cas1; Cat01; Catl; Cat; Cs-1", "protein_names_uniprotkb": "Catalase; 1.11.1.6", "protein_names_refseq": "catalase", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); colitis (Disease Ontology:DOID:0060180); mitochondrial complex IV deficiency nuclear type 18 (Disease Ontology:DOID:0070503); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); Graves ophthalmopathy (Disease Ontology:DOID:0081120); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); Raynaud disease (Disease Ontology:DOID:10300); pneumoconiosis (Disease Ontology:DOID:10316); retinitis pigmentosa (Disease Ontology:DOID:10584); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); optic neuritis (Disease Ontology:DOID:1210); tympanosclerosis (Disease Ontology:DOID:1214); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); keratosis (Disease Ontology:DOID:161); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); acatalasia (Disease Ontology:DOID:2582); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast adenocarcinoma (Disease Ontology:DOID:3458); toxic encephalopathy (Disease Ontology:DOID:3602); gastric adenocarcinoma (Disease Ontology:DOID:3717); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); pulmonary fibrosis (Disease Ontology:DOID:3770); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ureteral obstruction (Disease Ontology:DOID:5199); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); acne (Disease Ontology:DOID:6543); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); scabies (Disease Ontology:DOID:8295); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); seborrheic dermatitis (Disease Ontology:DOID:8741); psoriasis (Disease Ontology:DOID:8893); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); pemphigus (Disease Ontology:DOID:9182); lichen planus (Disease Ontology:DOID:9201); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); stomatitis (Disease Ontology:DOID:9637); senile cataract (Disease Ontology:DOID:9669); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (rno:24248); (R-RNO-3299685); (R-RNO-6798695); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "22673903;23064900;26961980;2792765;29393594;29847079;3455767;6547842", "class_list": "", "function": "Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. 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"https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0006979 response to oxidative stress;GO:0008203 cholesterol metabolic process;GO:0010288 response to lead ion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P04762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MA04-1", "uniprot_id": [ { "id": "F1MA04_RAT", "url": "https://www.uniprot.org/uniprot/F1MA04", "type": "external" } ], "mass": 99408.0, "length": 898, "protein_name": "WD repeat domain 36", "gene_name": "Wdr36", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr36", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat domain 36", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (R-RNO-6791226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0001895 retina homeostasis;GO:0030516 regulation of axon extension;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MA04-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0Y0-1", "uniprot_id": [ { "id": "A0A0G2K0Y0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0Y0", "type": "external" } ], "mass": 105449.0, "length": 980, "protein_name": "BicC family RNA binding protein 1", "gene_name": "Bicc1", "organism": "Rat", "refseq_name": "protein bicaudal C homolog 1", "refseq_ac": [ { "id": "NP_001402002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402002", "type": "external" } ], "gene_names_uniprotkb": "Bicc1", "gene_names_refseq": "Bicc1", "protein_names_uniprotkb": "BicC family RNA binding protein 1", "protein_names_refseq": "bicaudal C homolog 1; protein bicaudal C homolog 1", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); cystic renal dysplasia (Disease Ontology:DOID:0111682); cystic kidney disease (Disease Ontology:DOID:2975); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:361832)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25178406", "class_list": "", "function": "Findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, 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"gene_names_uniprotkb": "Aga", "gene_names_refseq": "Aga", "protein_names_uniprotkb": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; 3.5.1.26; AGA; Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase", "protein_names_refseq": "N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase precursor; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; glycosylasparaginase; n(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase", "tax_id": 10116, "disease": "aspartylglucosaminuria (Disease Ontology:DOID:0050461); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (rno:290923); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1554372;2775174", "class_list": "", "function": "Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, 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"binding_glycan_count": 0, "secondary_ac_list": "Q4G065", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": 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peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0006517 protein deglycosylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30919-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50297-1", "uniprot_id": [ { "id": "ARY1_RAT", "url": "https://www.uniprot.org/uniprot/P50297", "type": "external" } ], "mass": 33437.0, "length": 290, "protein_name": "Arylamine N-acetyltransferase 1", "gene_name": "Nat1; Nat2; Nat3", "organism": "Rat", "refseq_name": "arylamine N-acetyltransferase 1", "refseq_ac": [ { "id": "NP_001032392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032392", "type": "external" } ], "gene_names_uniprotkb": "Nat1; Nat2; Nat3; Aac1; Nat3", "gene_names_refseq": "Nat1; Nat", "protein_names_uniprotkb": "Arylamine N-acetyltransferase 1; 2.3.1.5; AT-1; Arylamide acetylase 1; N-acetyltransferase type 1; NAT-1", "protein_names_refseq": "AT-1; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; NAT-1; arylamide acetylase 1; arylamine N-acetyltransferase 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); leukemia (Disease Ontology:DOID:1240); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); occupational dermatitis (Disease Ontology:DOID:4404); cholangiocarcinoma (Disease Ontology:DOID:4947); progressive supranuclear palsy (Disease Ontology:DOID:678); lung disease (Disease Ontology:DOID:850); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:116631); (rno:290681); (R-RNO-156582); (R-RNO-9753281)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18799802;22225631;7882993;8761433", "class_list": "", "function": "A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells., [RefSeq, PubMed]; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Acetylates both arylamines and arylalkylamines., [UniProtKB, PubMed, PubMed]; Results demonstrate differential tissue-specific and developmental regulation of the rat Nat1 and Nat2 genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.5", "type": "external" }, { "id": "2.3.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.118", "type": "external" } ], "go_molecular_function": "GO:0004060 arylamine N-acetyltransferase activity;GO:0015179 L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0097068 response to thyroxine;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33124-1", "uniprot_id": [ { "id": "ACSL6_RAT", "url": "https://www.uniprot.org/uniprot/P33124", "type": "external" } ], "mass": 78180.0, "length": 697, "protein_name": "Long-chain-fatty-acid--CoA ligase 6", "gene_name": "Acsl6", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase 6 isoform 3", "refseq_ac": [ { "id": "NP_570095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570095", "type": "external" } ], "gene_names_uniprotkb": "Acsl6; Acs2; Facl6", "gene_names_refseq": "Acsl6; Facl6; LACS 6; Lacsl", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 6; 6.2.1.15; 6.2.1.3; Arachidonate--CoA ligase; LACS 6; Long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase, brain isozyme", "protein_names_refseq": "arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 6; long-chain acyl-CoA synthetase 6; long-chain-fatty-acid--CoA ligase 6 isoform 3; long-chain-fatty-acid--CoA ligase 6; long-chain-fatty-acid--CoA ligase, brain isozyme", "tax_id": 10116, "disease": "leukemia (Disease Ontology:DOID:1240); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:117243); (R-RNO-75876)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15683247;1569043;1654331;27647415;28209804;35976155;8973631", "class_list": "", "function": "ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation, [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:28209804). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid., [UniProtKB, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63835;Q6IU14", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0007584 response to nutrient;GO:0010976 positive regulation of neuron projection development;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P33124-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10743-1", "uniprot_id": [ { "id": "ADA10_RAT", "url": "https://www.uniprot.org/uniprot/Q10743", "type": "external" } ], "mass": 84087.0, "length": 749, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "Adam10", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 10 precursor", "refseq_ac": [ { "id": "NP_062127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062127", "type": "external" } ], "gene_names_uniprotkb": "Adam10; Madm", "gene_names_refseq": "Adam10; MADM", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 10; 3.4.24.81; ADAM 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease", "protein_names_refseq": "ADAM 10; RGD1566370; a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain 10; disintegrin and metalloproteinase domain-containing protein 10 precursor; disintegrin and metalloproteinase domain-containing protein 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); reticulate acropigmentation of Kitamura (Disease Ontology:DOID:0060258); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease 18 (Disease Ontology:DOID:0110050); Alzheimer's disease (Disease Ontology:DOID:10652); thoracic aortic aneurysm (Disease Ontology:DOID:14004); status epilepticus (Disease Ontology:DOID:1824); atopic dermatitis (Disease Ontology:DOID:3310); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:29650); (R-RNO-1474228); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275); (R-RNO-9013507)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "24090084;30989630;34647720;38843836;8694785", "class_list": "", "function": "Abeta1-42 oligomers trigger an aberrant plasticity mechanism according to which Abeta1-42 oligomers can downregulate Abeta generation through the modulation of ADAM10 synaptic availability., [RefSeq, PubMed]; Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling., [RefSeq, PubMed]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (By similarity). Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K562", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006509 membrane protein ectodomain proteolysis;GO:0007162 negative regulation of cell adhesion;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q10743-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK30-1", "uniprot_id": [ { "id": "DAW1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK30", "type": "external" } ], "mass": 45859.0, "length": 415, "protein_name": "Dynein assembly factor with WD repeat domains 1", "gene_name": "Daw1", "organism": "Rat", "refseq_name": "dynein assembly factor with WD repeat domains 1", "refseq_ac": [ { "id": "NP_001020196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020196", "type": "external" } ], "gene_names_uniprotkb": "Daw1; Wdr69", "gene_names_refseq": "Daw1; Wdr69", "protein_names_uniprotkb": "Dynein assembly factor with WD repeat domains 1; Outer row dynein assembly protein 16 homolog; WD repeat-containing protein 69", "protein_names_refseq": "WD repeat-containing protein 69; dynein assembly factor with WD repeat domains 1; dynein assembly factor with WDR repeat domains 1; outer row dynein assembly protein 16 homolog", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:363267)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. Facilitates the onset of robust cilia motility during development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium;GO:0019005 SCF ubiquitin ligase complex;GO:0036064 ciliary basal body", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0007368 determination of left/right symmetry;GO:0000209 protein polyubiquitination;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK30-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBJ5-1", "uniprot_id": [ { "id": "ATG12_RAT", "url": "https://www.uniprot.org/uniprot/Q2TBJ5", "type": "external" } ], "mass": 15284.0, "length": 141, "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "Atg12", "organism": "Rat", "refseq_name": "ubiquitin-like protein ATG12", "refseq_ac": [ { "id": "NP_001033584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033584", "type": "external" } ], "gene_names_uniprotkb": "Atg12; Apg12l", "gene_names_refseq": "Apg12l; Atg12", "protein_names_uniprotkb": "Ubiquitin-like protein ATG12; APG12-like; Autophagy-related protein 12", "protein_names_refseq": "ATG12 autophagy related 12 homolog; autophagy 12-like; autophagy-related protein 12; ubiquitin-like protein ATG12", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)", "pathway": " (rno:361321); (R-RNO-1632852); (R-RNO-5205685); (R-RNO-8934903)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "18521932;19696026;24187137;27630106;33513383;33673233", "class_list": "", "function": "Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats., [RefSeq, PubMed]; Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Study demonstrated that miR-23b expression was significantly downregulated following traumatic brain injury (TBI). In model TBI, overexpression of miR-23b reduced the lesion volume, brain edema and neuronal apoptosis, and improves cognitive dysfunction. miR-23b specifically bound with the 3' UTR of ATG12 mRNA and modulated its translation; suppressed neuronal autophagy by directly targeting ATG12 expression., [RefSeq, PubMed]; Ubiquitin-like protein involved in autophagic vesicle formation., [UniProtKB, UniProtKB, UniProtKB]; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity). As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M9F9", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0000421 autophagosome membrane;GO:0016020 membrane;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:1904973 positive regulation of viral translation;GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2TBJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7C7-1", "uniprot_id": [ { "id": "ARP3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7C7", "type": "external" } ], "mass": 47357.0, "length": 418, "protein_name": "Actin-related protein 3", "gene_name": "Actr3", "organism": "Rat", "refseq_name": "actin-related protein 3", "refseq_ac": [ { "id": "NP_112330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112330", "type": "external" } ], "gene_names_uniprotkb": "Actr3; Arp3", "gene_names_refseq": "Actr3; Arp3", "protein_names_uniprotkb": "Actin-related protein 3; Actin-like protein 3", "protein_names_refseq": "ARP3 actin related protein 3 homolog; actin-like protein 3; actin-related protein 3 homolog (yest); actin-related protein 3", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); opisthorchiasis (Disease Ontology:DOID:13768); glioblastoma (Disease Ontology:DOID:3068); gallbladder carcinoma (Disease Ontology:DOID:4948); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:81732); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "18064521;19343716;31975378", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis., [UniProtKB, UniProtKB]; Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9CM89;A9CM90", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0061851 leading edge of lamellipodium;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4V7C7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVP8-1", "uniprot_id": [ { "id": "DGAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVP8", "type": "external" } ], "mass": 43795.0, "length": 388, "protein_name": "Diacylglycerol O-acyltransferase 2", "gene_name": "Dgat2", "organism": "Rat", "refseq_name": "diacylglycerol O-acyltransferase 2", "refseq_ac": [ { "id": "NP_001012345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012345", "type": "external" } ], "gene_names_uniprotkb": "Dgat2", "gene_names_refseq": "ARAT; Dgat2", "protein_names_uniprotkb": "Diacylglycerol O-acyltransferase 2; 2.3.1.20; 2.3.1.76; ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2; Retinol O-fatty-acyltransferase", "protein_names_refseq": "acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:252900); (R-RNO-1482883); (R-RNO-75109)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12235188;25164810", "class_list": "", "function": "Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (By similarity). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ontogeny of the two functional diacylglycerol acyltransferase (DGAT) activities (overt and latent) during postnatal development in rat liver, [RefSeq, PubMed]; The interaction of DGAT2 and MGAT2 serves to channel lipid substrates efficiently for triacylglycerol biosynthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4Y4", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0050252 retinol O-fatty-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0046339 diacylglycerol metabolic process;GO:0097006 regulation of plasma lipoprotein particle levels;GO:0007584 response to nutrient;GO:0046322 negative regulation of fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97536-1", "uniprot_id": [ { "id": "CAND1_RAT", "url": "https://www.uniprot.org/uniprot/P97536", "type": "external" } ], "mass": 136362.0, "length": 1230, "protein_name": "Cullin-associated NEDD8-dissociated protein 1", "gene_name": "Cand1", "organism": "Rat", "refseq_name": "cullin-associated NEDD8-dissociated protein 1", "refseq_ac": [ { "id": "NP_446456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446456", "type": "external" } ], "gene_names_uniprotkb": "Cand1; Tip120a; Tip120", "gene_names_refseq": "Cand1; Tip120A; Tip120", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; p120 CAND1", "protein_names_refseq": "TBP-interacting protein 120A; TBP-interacting protein TIP120A; TBP-interacting protein of 120 kDa A; cullin associated and neddylation disassociated 1; cullin-associated NEDD8-dissociated protein 1; cullin-associated and neddylation-dissociated protein 1; p120 CAND1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:117152); (R-RNO-6798695); (R-RNO-8951664); (R-RNO-917937)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10441524;10567521;18683930;22673903;29367474;34974108;38095165;8954946", "class_list": "", "function": "Inhibition of miR-29a-3p Alleviates Apoptosis of Lens Epithelial Cells via Upregulation of CAND1., [RefSeq, PubMed]; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity). May indirectly enhance transcription from various types of promoters., [UniProtKB, PubMed]; LncRNA RMRP knockdown promotes proliferation and migration of Schwann cells by mediating the miR-766-5p/CAND1 axis., [RefSeq, PubMed]; The findings indicate that CAND1 inhibits the ubiquitylation of rabphilin-3A and positively regulates AVP secretion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0043086 negative regulation of catalytic activity;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97536-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20673-1", "uniprot_id": [ { "id": "ARLY_RAT", "url": "https://www.uniprot.org/uniprot/P20673", "type": "external" } ], "mass": 51550.0, "length": 461, "protein_name": "Argininosuccinate lyase", "gene_name": "Asl", "organism": "Rat", "refseq_name": "argininosuccinate lyase", "refseq_ac": [ { "id": "NP_067588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067588", "type": "external" } ], "gene_names_uniprotkb": "Asl", "gene_names_refseq": "Asl", "protein_names_uniprotkb": "Argininosuccinate lyase; 4.3.2.1; ASAL; Arginosuccinase", "protein_names_refseq": "ASAL; argininosuccinate lyase; arginosuccinase", "tax_id": 10116, "disease": "argininosuccinic aciduria (Disease Ontology:DOID:14755); hepatocellular carcinoma (Disease Ontology:DOID:684); amino acid metabolic disorder (Disease Ontology:DOID:9252); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:59085); (R-RNO-70635)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "24904080;2725197;2789519;2834354;8485149", "class_list": "", "function": "Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Enterocyte-derived ASL has a protective role in necrotizing enterocolitis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ85", "ec_number_list": [ { "id": "4.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004056 argininosuccinate lyase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:0001889 liver development;GO:0007584 response to nutrient;GO:0007626 locomotory behavior;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20673-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8K5-1", "uniprot_id": [ { "id": "BROX_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8K5", "type": "external" } ], "mass": 46192.0, "length": 411, "protein_name": "BRO1 domain-containing protein BROX", "gene_name": "Brox", "organism": "Rat", "refseq_name": "BRO1 domain-containing protein BROX", "refseq_ac": [ { "id": "NP_001020840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020840", "type": "external" } ], "gene_names_uniprotkb": "Brox", "gene_names_refseq": "Brox; RGD1307161", "protein_names_uniprotkb": "BRO1 domain-containing protein BROX; BRO1 domain- and CAAX motif-containing protein", "protein_names_refseq": "BRO1 domain- and CAAX motif-containing protein; BRO1 domain-containing protein BROX", "tax_id": 10116, "disease": "", "pathway": " (rno:305031)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007084 mitotic nuclear membrane reassembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51952-1", "uniprot_id": [ { "id": "CDK7_RAT", "url": "https://www.uniprot.org/uniprot/P51952", "type": "external" } ], "mass": 37141.0, "length": 329, "protein_name": "Cyclin-dependent kinase 7", "gene_name": "Cdk7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk7; Cak1; Cak; Mo15", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 7; 2.7.11.22; 2.7.11.23; 39 protein kinase; CDK-activating kinase 1; Cell division protein kinase 7; P39 Mo15; TFIIH basal transcription factor complex kinase subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary congenital glaucoma (Disease Ontology:DOID:0050593); brachydactyly type A2 (Disease Ontology:DOID:0110965); Alzheimer's disease (Disease Ontology:DOID:10652); essential hypertension (Disease Ontology:DOID:10825); breast cancer (Disease Ontology:DOID:1612); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6807505); (R-RNO-69200); (R-RNO-69202); (R-RNO-69231); (R-RNO-69273); (R-RNO-69656); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-8939236)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (By similarity). As a cyclin-dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and the CDK-activating kinase assembly factor MAT1 (By similarity). Catalytic subunit of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the CTD of POLR2A, allowing its escape from the promoter and elongation of the transcripts (By similarity). Initiates transcription by RNA polymerase II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting dissociation from DNA and initiation (By similarity). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (By similarity). Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1L0-1", "uniprot_id": [ { "id": "A16A1_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1L0", "type": "external" } ], "mass": 85414.0, "length": 802, "protein_name": "Aldehyde dehydrogenase family 16 member A1", "gene_name": "Aldh16a1", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase family 16 member A1", "refseq_ac": [ { "id": "NP_001028878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028878", "type": "external" } ], "gene_names_uniprotkb": "Aldh16a1", "gene_names_refseq": "Aldh16a1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 16 member A1", "protein_names_refseq": "aldehyde dehydrogenase 16A1; aldehyde dehydrogenase family 16 member A1", "tax_id": 10116, "disease": "", "pathway": " (rno:361571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1L0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20420-1", "uniprot_id": [ { "id": "ACHA5_RAT", "url": "https://www.uniprot.org/uniprot/P20420", "type": "external" } ], "mass": 51874.0, "length": 452, "protein_name": "Neuronal acetylcholine receptor subunit alpha-5", "gene_name": "Chrna5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chrna5; Acra5", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congenital myasthenic syndrome (Disease Ontology:DOID:3635); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:25102); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1689727", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20420-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0C4-1", "uniprot_id": [ { "id": "ABHEA_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0C4", "type": "external" } ], "mass": 26761.0, "length": 242, "protein_name": "Protein ABHD14A", "gene_name": "Abhd14a", "organism": "Rat", "refseq_name": "protein ABHD14A", "refseq_ac": [ { "id": "NP_001009670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009670", "type": "external" } ], "gene_names_uniprotkb": "Abhd14a", "gene_names_refseq": "Abhd14a; Dorz1; RGD1309721", "protein_names_uniprotkb": "Protein ABHD14A; 3.-.-.-; Abhydrolase domain-containing protein 14A; Alpha/beta hydrolase domain-containing protein 14A", "protein_names_refseq": "abhydrolase domain-containing protein 14A; alpha/beta hydrolase domain-containing protein 14A; down-regulated in Zic1 deficient cerebellar primordium; protein ABHD14A", "tax_id": 10116, "disease": "", "pathway": " (rno:300982)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Possible role in granule neuron development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0C4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVL4-1", "uniprot_id": [ { "id": "DRC12_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVL4", "type": "external" } ], "mass": 23407.0, "length": 202, "protein_name": "Dynein regulatory complex protein 12", "gene_name": "Drc12", "organism": "Rat", "refseq_name": "dynein regulatory complex protein 12", "refseq_ac": [ { "id": "NP_001013975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013975", "type": "external" } ], "gene_names_uniprotkb": "Drc12; Ccdc153", "gene_names_refseq": "Ccdc153; Drc12; RGD1305351", "protein_names_uniprotkb": "Dynein regulatory complex protein 12", "protein_names_refseq": "coiled-coil domain containing 153; coiled-coil domain-containing protein 153; dynein regulatory complex protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:300663)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68255-1", "uniprot_id": [ { "id": "1433T_RAT", "url": "https://www.uniprot.org/uniprot/P68255", "type": "external" } ], "mass": 27778.0, "length": 245, "protein_name": "14-3-3 protein theta", "gene_name": "Ywhaq", "organism": "Rat", "refseq_name": "14-3-3 protein theta", "refseq_ac": [ { "id": "NP_037185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037185", "type": "external" } ], "gene_names_uniprotkb": "Ywhaq", "gene_names_refseq": "14-3-3t; Ywhaq", "protein_names_uniprotkb": "14-3-3 protein theta; 14-3-3 protein tau", "protein_names_refseq": "14-3-3 protein tau; 14-3-3 protein theta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:25577); (R-RNO-111447); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-75035); (R-RNO-9614399)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "18683930;21618583;22911758;34502162;7984035", "class_list": "", "function": "14-3-3theta; is a binding partner of rEag1 and may modulate the functional expression of the K(+) channel in neurons., [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)., [UniProtKB]; Results showed that sepsis alters the expression of the 14-3-3 theta; isoform in a time-, cell-, and topography-dependent manner, with the hippocampus, Purkinje cells, and glia-like cells showed intense immunohistochemical reactivity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35216", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006605 protein targeting;GO:0045892 negative regulation of DNA-templated transcription;GO:0007264 small GTPase-mediated signal transduction;GO:0034766 negative regulation of monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P68255-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM91-1", "uniprot_id": [ { "id": "CDCA7_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM91", "type": "external" } ], "mass": 43024.0, "length": 377, "protein_name": "Cell division cycle-associated protein 7", "gene_name": "Cdca7", "organism": "Rat", "refseq_name": "cell division cycle-associated protein 7", "refseq_ac": [ { "id": "NP_001020864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020864", "type": "external" } ], "gene_names_uniprotkb": "Cdca7", "gene_names_refseq": "Cdca7", "protein_names_uniprotkb": "Cell division cycle-associated protein 7", "protein_names_refseq": "cell division cycle-associated protein 7", "tax_id": 10116, "disease": "immunodeficiency-centromeric instability-facial anomalies syndrome 3 (Disease Ontology:DOID:0090010)", "pathway": " (rno:311742)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11598121;22673903", "class_list": "", "function": "Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis (PubMed:11598121). Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044729 hemi-methylated DNA-binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KM91-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60889-1", "uniprot_id": [ { "id": "CBX7_RAT", "url": "https://www.uniprot.org/uniprot/P60889", "type": "external" } ], "mass": 17966.0, "length": 158, "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "organism": "Rat", "refseq_name": "chromobox protein homolog 7", "refseq_ac": [ { "id": "NP_954548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954548", "type": "external" } ], "gene_names_uniprotkb": "Cbx7", "gene_names_refseq": "Cbx7", "protein_names_uniprotkb": "Chromobox protein homolog 7", "protein_names_refseq": "chromobox homolog 7; chromobox protein homolog 7", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); anaplastic thyroid carcinoma (Disease Ontology:DOID:0080522); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); clear cell adenocarcinoma (Disease Ontology:DOID:4468); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); myeloid leukemia (Disease Ontology:DOID:8692); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:362962)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "36222130;38809351", "class_list": "", "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded and double-stranded RNA. Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (By similarity)., [UniProtKB, UniProtKB]; Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway., [RefSeq, PubMed]; Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003727 single-stranded RNA binding;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0048733 sebaceous gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60889-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23347-1", "uniprot_id": [ { "id": "B3A2_RAT", "url": "https://www.uniprot.org/uniprot/P23347", "type": "external" } ], "mass": 136636.0, "length": 1234, "protein_name": "Anion exchange protein 2", "gene_name": "Slc4a2", "organism": "Rat", "refseq_name": "anion exchange protein 2", "refseq_ac": [ { "id": "NP_058744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058744", "type": "external" } ], "gene_names_uniprotkb": "Slc4a2; Ae2; B3rp2", "gene_names_refseq": "Ae2; Aep2; Slc4a2", "protein_names_uniprotkb": "Anion exchange protein 2; AE 2; Anion exchanger 2; B3RP-2; Band 3-related protein 2; Non-erythroid band 3-like protein; Solute carrier family 4 member 2", "protein_names_refseq": "AE 2; AE2 Cl-/HCO3-exchanger, variant AE2b; B3RP-2; Solute carrier family 4, member 2, anion exchange protein 2; anion exchange protein 2; anion exchanger 2; band 3-related protein 2; non-erythroid band 3-like protein; solute carrier family 4 (anion exchanger), member 2", "tax_id": 10116, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); Parkinsonism (Disease Ontology:DOID:0080855); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prediabetes syndrome (Disease Ontology:DOID:11716); osteopetrosis (Disease Ontology:DOID:13533); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:24780); (R-RNO-425381)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10600827;22310983;22673903;2294114;23059814;2371270;24192602;26319954;8141271", "class_list": "", "function": "Results indicate that the increase in bile flow induced by rifampicin is mainly due to increased HCO3 (-) excretion mediated by increased AE2 protein expression and activity., [RefSeq, PubMed]; Results suggest that exhaustive running exercise results in elevated band-3 tyrosine phosphorylation and alters band-3 membrane organization., [RefSeq, PubMed]; Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:2371270). Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity)., [UniProtKB, UniProtKB, PubMed]; These results demonstrate that NHE1 and AE2 are important regulators of bone growth., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0022857 transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045124 regulation of bone resorption;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P23347-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24483-1", "uniprot_id": [ { "id": "ADX_RAT", "url": "https://www.uniprot.org/uniprot/P24483", "type": "external" } ], "mass": 20135.0, "length": 188, "protein_name": "Adrenodoxin, mitochondrial", "gene_name": "Fdx1", "organism": "Rat", "refseq_name": "adrenodoxin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_058822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058822", "type": "external" } ], "gene_names_uniprotkb": "Fdx1", "gene_names_refseq": "Fdx1", "protein_names_uniprotkb": "Adrenodoxin, mitochondrial; Adrenal ferredoxin; Ferredoxin-1", "protein_names_refseq": "adrenal ferredoxin; adrenodoxin, mitochondrial precursor; adrenodoxin, mitochondrial", "tax_id": 10116, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:29189); (R-RNO-1362409); (R-RNO-196108); (R-RNO-211976); (R-RNO-2395516); (R-RNO-9857492)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "1863358;2170421;37858707;8820908", "class_list": "", "function": "Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons., [UniProtKB, UniProtKB]; FDX1 Is Required for the Biogenesis of Mitochondrial Cytochrome c Oxidase in Mammalian Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0051353 positive regulation of oxidoreductase activity;GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P24483-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04679-1", "uniprot_id": [ { "id": "ATNG_RAT", "url": "https://www.uniprot.org/uniprot/Q04679", "type": "external" } ], "mass": 7257.0, "length": 66, "protein_name": "Sodium/potassium-transporting ATPase subunit gamma", "gene_name": "Fxyd2", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit gamma isoform b", "refseq_ac": [ { "id": "NP_059045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059045", "type": "external" } ], "gene_names_uniprotkb": "Fxyd2; Atp1c; Atp1g1", "gene_names_refseq": "ATP1C; Atp1g1; Fxyd2; GNAKATP", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Na(+)/K(+) ATPase subunit gamma; Sodium pump gamma chain", "protein_names_refseq": "ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXTD domain-containing ion transport regulator 2; Na(+)/K(+) ATPase subunit gamma; gamma subunit of sodium potassium ATPase; sodium pump gamma chain; sodium/potassium-transporting ATPase gamma chain; sodium/potassium-transporting ATPase subunit gamma isoform b; sodium/potassium-transporting ATPase subunit gamma", "tax_id": 10116, "disease": "renal hypomagnesemia 2 (Disease Ontology:DOID:0060885)", "pathway": " (rno:29639); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10212192;11756431;11832419;16373350;16757733;21460224;8387529", "class_list": "", "function": "Data describe the interactions of rat FXYD1,-2, and -4 proteins with rat alpha1 subunits of Na(+),K(+)-ATPase., [RefSeq, PubMed]; Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit, [RefSeq, PubMed]; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase., [UniProtKB, UniProtKB, UniProtKB]; Post-transcriptional control of Na,K-ATPase activity and cell growth by a splice variant of FXYD2 protein with modified mRNA., [RefSeq, PubMed]; The unchanged levels of FXYD2 and FXYD4 proteins suggest that they are not primary determinants for urine electrolyte composition during NaCl depletion., [RefSeq, PubMed]; This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. This gene, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. Related gene family members have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members, with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Two transcript variants have been described for this gene that encode distinct isoforms. [provided by RefSeq, Jan 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKN3;Q9WUD3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017080 sodium channel regulator activity;GO:0001671 ATPase activator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0055085 transmembrane transport;GO:2000649 regulation of sodium ion transmembrane transporter activity;GO:0006812 monoatomic cation transport;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04679-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27653-1", "uniprot_id": [ { "id": "C1TC_RAT", "url": "https://www.uniprot.org/uniprot/P27653", "type": "external" } ], "mass": 100996.0, "length": 935, "protein_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "gene_name": "Mthfd1", "organism": "Rat", "refseq_name": "C-1-tetrahydrofolate synthase, cytoplasmic", "refseq_ac": [ { "id": "NP_071953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071953", "type": "external" } ], "gene_names_uniprotkb": "Mthfd1; Mthfd", "gene_names_refseq": "Mthfd1", "protein_names_uniprotkb": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase", "protein_names_refseq": "C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; C1-tetrahydrofolate synthase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase", "tax_id": 10116, "disease": "spina bifida (Disease Ontology:DOID:0080016); neural tube defect (Disease Ontology:DOID:0080074); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); Down syndrome (Disease Ontology:DOID:14250); tetralogy of Fallot (Disease Ontology:DOID:6419); cleft palate (Disease Ontology:DOID:674); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (rno:64300); (R-RNO-196757)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14597174;2186031", "class_list": "", "function": "Gene encodes the cytoplasmic isozyme of C1-tetrahydrofolate (THF) synthase, a trifunctional enzyme containing formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase activities (EC Numbers: 1.5.1.5, 3.5.4.9, 6.3.4.3)., [RefSeq, PubMed]; Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62808", "ec_number_list": [ { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" }, { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" }, { "id": "1.5.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.5", "type": "external" }, { "id": "1.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004329 formate-tetrahydrofolate ligase activity;GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0009152 purine ribonucleotide biosynthetic process;GO:0007507 heart development;GO:0001843 neural tube closure;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27653-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41682-1", "uniprot_id": [ { "id": "ADH7_RAT", "url": "https://www.uniprot.org/uniprot/P41682", "type": "external" } ], "mass": 40105.0, "length": 374, "protein_name": "All-trans-retinol dehydrogenase [NAD(+)] ADH7", "gene_name": "Adh7", "organism": "Rat", "refseq_name": "all-trans-retinol dehydrogenase [NAD(+)] ADH7", "refseq_ac": [ { "id": "NP_599156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599156", "type": "external" } ], "gene_names_uniprotkb": "Adh7", "gene_names_refseq": "Adh7", "protein_names_uniprotkb": "All-trans-retinol dehydrogenase [NAD(+)] ADH7; 1.1.1.105; 1.1.1.1; 1.1.1.66; Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Omega-hydroxydecanoate dehydrogenase ADH7", "protein_names_refseq": "alcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase class IV mu/sigma chain; all-trans-retinol dehydrogenase [NAD(+)] ADH7; class IV alcohol dehydrogenase, mu or sigma subunit; omega-hydroxydecanoate dehydrogenase ADH7", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:171178); (R-RNO-211935); (R-RNO-71384)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10829036;18424432;8127901;9600267", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NO generation from nitrite mainly occurs in tissues not in the blood, with XO and AO playing critical roles in nitrite reduction, and this process is regulated by pH, oxygen tension, nitrite, and reducing substrate concentrations, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55146", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004031 aldehyde oxidase activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0045471 response to ethanol;GO:0006068 ethanol catabolic process;GO:0009617 response to bacterium;GO:0010430 fatty acid omega-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1I2-1", "uniprot_id": [ { "id": "C1QT6_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1I2", "type": "external" } ], "mass": 28973.0, "length": 263, "protein_name": "Complement C1q tumor necrosis factor-related protein 6", "gene_name": "C1qtnf6", "organism": "Rat", "refseq_name": "complement C1q tumor necrosis factor-related protein 6 precursor", "refseq_ac": [ { "id": "NP_001030104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030104", "type": "external" } ], "gene_names_uniprotkb": "C1qtnf6", "gene_names_refseq": "Adiq; C1qtnf6; Ctrp6", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 6", "protein_names_refseq": "C1q and tumor necrosis factor related protein 6; adiponectin q; complement C1q tumor necrosis factor-related protein 6 precursor; complement C1q tumor necrosis factor-related protein 6", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:315114)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27774934;27871858;32377750", "class_list": "", "function": "C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in gentamicin-induced acute kidney injury in rats, [RefSeq, PubMed]; CTRP6 improves PPARgamma activation and alleviates AngII-induced hypertension and vascular endothelial dysfunction, [RefSeq, PubMed]; Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3T1I2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28023-1", "uniprot_id": [ { "id": "DCTN1_RAT", "url": "https://www.uniprot.org/uniprot/P28023", "type": "external" } ], "mass": 141930.0, "length": 1280, "protein_name": "Dynactin subunit 1", "gene_name": "C4h2orf81; Dctn1", "organism": "Rat", "refseq_name": "dynactin subunit 1", "refseq_ac": [ { "id": "NP_077044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077044", "type": "external" } ], "gene_names_uniprotkb": "C4h2orf81; Dctn1; C4h2orf81; Dctn1; LOC500227", "gene_names_refseq": "Dctn1", "protein_names_uniprotkb": "Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p150-glued", "protein_names_refseq": "150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1; dynactin subunit 1; p150-glued", "tax_id": 10116, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Perry syndrome (Disease Ontology:DOID:0060486); autosomal dominant distal hereditary motor neuronopathy 14 (Disease Ontology:DOID:0111202); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:29167); (R-RNO-2132295); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-8854518)", "pathway_count": 12, "publication_count": 9, "publication_id_list": "1828535;18683930;21931181;22673903;22777741;23648839;28000671;31445682;38843836", "class_list": "", "function": "Conformational Flexibility of p150(Glued)(1-191) Subunit of Dynactin Assembled with Microtubules., [RefSeq, PubMed]; Data show that axonal synthesis of Lis1 and p150Glued is required for the adjustment of retrograde transport to acutely changing neurotrophin signalling in the periphery of neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0007077 mitotic nuclear membrane disassembly;GO:0007528 neuromuscular junction development;GO:0050905 neuromuscular process;GO:0051301 cell division;GO:0070050 neuron cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28023-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20850-1", "uniprot_id": [ { "id": "CO9A1_RAT", "url": "https://www.uniprot.org/uniprot/P20850", "type": "external" } ], "mass": 31256.0, "length": 325, "protein_name": "Collagen alpha-1(IX) chain", "gene_name": "Col9a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Col9a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(IX) chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "multiple epiphyseal dysplasia 6 (Disease Ontology:DOID:0070301); Stickler syndrome (Disease Ontology:DOID:0080046); dilated cardiomyopathy (Disease Ontology:DOID:12930); osteochondrodysplasia (Disease Ontology:DOID:2256); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:305104)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2465149", "class_list": "", "function": "Structural component of hyaline cartilage and vitreous of the eye., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0001894 tissue homeostasis;GO:0001501 skeletal system development;GO:0060349 bone morphogenesis;GO:0002062 chondrocyte differentiation;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20850-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11030-1", "uniprot_id": [ { "id": "ACBP_RAT", "url": "https://www.uniprot.org/uniprot/P11030", "type": "external" } ], "mass": 10027.0, "length": 87, "protein_name": "Acyl-CoA-binding protein", "gene_name": "Dbi", "organism": "Rat", "refseq_name": "acyl-CoA-binding protein", "refseq_ac": [ { "id": "NP_114054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114054", "type": "external" } ], "gene_names_uniprotkb": "Dbi", "gene_names_refseq": "Acbp; Acoabp3; Dbi; Ep; Odn; RNACOABP3; Ttn", "protein_names_uniprotkb": "Acyl-CoA-binding protein; ACBP; DBI; Diazepam-binding inhibitor; EP; Endozepine", "protein_names_refseq": "Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenxyme A binding protein); GABA receptor modulator; LRRGT00046; acyl-CoA-binding protein; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein); diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam binding inhibitor-like; diazepam-binding inhibitor; endozepine; octadecaneuropeptide; triakontatetraneuropeptide", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); cardiovascular system disease (Disease Ontology:DOID:1287); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (rno:25045); (R-RNO-77289)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1469708;23160530;2769267;2803267;2821429;28698967;3463960;39056770;7690962;8964506", "class_list": "", "function": "Astrocytes produce authentic ODN, notably in a moderate oxidative stress situation, and this glio- and neuro-protective agent may form part of the brain defense mechanisms against oxidative stress injury., [RefSeq, PubMed]; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor., [UniProtKB]; Data suggest that neuroglia play important role in glucose sensing in hypothalamus and may regulate energy balance/appetite control through production/secretion of endozepines (diazepam binding inhibitor and processing product, octadecaneuropeptide)., [RefSeq, PubMed]; Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2V4X5;Q63160", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000062 fatty-acyl-CoA binding;GO:0030156 benzodiazepine receptor binding;GO:0036042 long-chain fatty acyl-CoA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0097038 perinuclear endoplasmic reticulum;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process;GO:0007611 learning or memory;GO:0031999 negative regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11030-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4AEF8-1", "uniprot_id": [ { "id": "COPG1_RAT", "url": "https://www.uniprot.org/uniprot/Q4AEF8", "type": "external" } ], "mass": 97614.0, "length": 874, "protein_name": "Coatomer subunit gamma-1", "gene_name": "Copg1", "organism": "Rat", "refseq_name": "coatomer subunit gamma-1", "refseq_ac": [ { "id": "NP_001026992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026992", "type": "external" } ], "gene_names_uniprotkb": "Copg1; Copg; Hmces", "gene_names_refseq": "Copg1; Copg", "protein_names_uniprotkb": "Coatomer subunit gamma-1; Gamma-1-COP; Gamma-1-coat protein", "protein_names_refseq": "COPI coat complex subunit gamma 1; coatomer protein complex, subunit gamma 1; coatomer subunit gamma-1; coatomer subunit gamma; gamma-1-COP; gamma-1-coat protein; gamma-COP; gamma-coat protein", "tax_id": 10116, "disease": "immunodeficiency 128 (Disease Ontology:DOID:0061093); combined immunodeficiency (Disease Ontology:DOID:0111962); polyclonal hypergammaglobulinemia (Disease Ontology:DOID:2344)", "pathway": " (rno:297428); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15978772;17360540", "class_list": "", "function": "Analysis of differential localization of coatomer complex isoforms within the Golgi apparatus, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0051683 establishment of Golgi localization;GO:0009306 protein secretion;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4AEF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8G7-1", "uniprot_id": [ { "id": "CENPU_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8G7", "type": "external" } ], "mass": 46801.0, "length": 410, "protein_name": "Centromere protein U", "gene_name": "Cenpu", "organism": "Rat", "refseq_name": "centromere protein U", "refseq_ac": [ { "id": "NP_001020844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020844", "type": "external" } ], "gene_names_uniprotkb": "Cenpu; Mlf1ip", "gene_names_refseq": "Cenpu; Mlf1ip", "protein_names_uniprotkb": "Centromere protein U; CENP-U; MLF1-interacting protein", "protein_names_refseq": "CENP-U; MLF1-interacting protein; centromere protein U; myeloid leukemia factor 1 interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:306464); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "15893739", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36876-1", "uniprot_id": [ { "id": "2ABA_RAT", "url": "https://www.uniprot.org/uniprot/P36876", "type": "external" } ], "mass": 51678.0, "length": 447, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "Ppp2r2a", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "refseq_ac": [ { "id": "NP_446451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446451", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r2a", "gene_names_refseq": "B55; Ppp2r2a", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; B55; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform BRA; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "tax_id": 10116, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (rno:117104); (R-RNO-2995383); (R-RNO-69231); (R-RNO-69273); (R-RNO-975957); (R-RNO-9860927)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "1370560;23775125;24433183;28343149;8389301", "class_list": "", "function": "Beta-AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A-dependent but requires B55alpha-PP2A-mediated dephosphorylation of Ser259/Ser498. Publication Status: Online-Only, [RefSeq, PubMed]; Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation., [RefSeq, PubMed]; Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition, [RefSeq, PubMed]; Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5M9;O35512;P36878", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0044877 protein-containing complex binding;GO:0048156 tau protein binding;GO:0051721 protein phosphatase 2A binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0045202 synapse;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0043278 response to morphine;GO:0006470 protein dephosphorylation;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36876-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1K5-1", "uniprot_id": [ { "id": "CAZA2_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1K5", "type": "external" } ], "mass": 32967.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-2", "gene_name": "Capza2", "organism": "Rat", "refseq_name": "F-actin-capping protein subunit alpha-2", "refseq_ac": [ { "id": "NP_001009180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009180", "type": "external" } ], "gene_names_uniprotkb": "Capza2", "gene_names_refseq": "Capza2", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-2; CapZ alpha-2", "protein_names_refseq": "F-actin-capping protein subunit alpha-2; capZ alpha-2; capping actin protein of muscle Z-line alpha subunit 2; capping protein (actin filament) muscle Z-line, alpha 2", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:493810); (R-RNO-879415)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12917688;22673903", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0016020 membrane;GO:0008290 F-actin capping protein complex;GO:0030863 cortical cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3T1K5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63035-1", "uniprot_id": [ { "id": "CYH2_RAT", "url": "https://www.uniprot.org/uniprot/P63035", "type": "external" } ], "mass": 46571.0, "length": 400, "protein_name": "Cytohesin-2", "gene_name": "Cyth2", "organism": "Rat", "refseq_name": "cytohesin-2 isoform 1", "refseq_ac": [ { "id": "NP_446363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446363", "type": "external" } ], "gene_names_uniprotkb": "Cyth2; Pscd2; Sec7b", "gene_names_refseq": "Arno; CLM2; Cyth2; Pscd2; Sec7B; Sec7", "protein_names_uniprotkb": "Cytohesin-2; ARF nucleotide-binding site opener; CLM2; PH, SEC7 and coiled-coil domain-containing protein 2; Protein ARNO; SEC7 homolog B", "protein_names_refseq": "ARF nucleotide binding site opener; PH, SEC7 and coiled-coil domain-containing protein 2; SEC7 homolog B; cytohesin-2 isoform 1; pleckstrin homology, Sec7 and coiled-coil domains 2", "tax_id": 10116, "disease": "", "pathway": " (rno:116692); (R-RNO-6811438)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11834294;11850456;12920129;17897316;23288846;38843836;9352219", "class_list": "", "function": "Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cytohesin 2 binds to IPCEF1, which modifies its activity, [RefSeq, PubMed]; Endotubin labels a distinct endosomal structure in neurons; and ARNO and ARF6 mediate neurite extension through the regulation of this compartment, [RefSeq, PubMed]; The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O89099;P97695", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:2000171 negative regulation of dendrite development;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P63035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08909-1", "uniprot_id": [ { "id": "5HT2C_RAT", "url": "https://www.uniprot.org/uniprot/P08909", "type": "external" } ], "mass": 51917.0, "length": 460, "protein_name": "5-hydroxytryptamine receptor 2C", "gene_name": "Htr2c", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 2C precursor", "refseq_ac": [ { "id": "NP_036897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036897", "type": "external" } ], "gene_names_uniprotkb": "Htr2c; 5ht1c; Htr1c", "gene_names_refseq": "5-HT2C; 5-HTR2C; 5HT-1C; Htr2c", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2C; 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; Serotonin receptor 2C", "protein_names_refseq": "5-HT-1C; 5-HT1C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C precursor; serotonin 1c receptor; serotonin receptor 2C", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Prader-Willi syndrome (Disease Ontology:DOID:11983); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:25187); (R-RNO-390666); (R-RNO-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12682077;31706992;31883927;33837045;3399891;34762147", "class_list": "", "function": "5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:3399891). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone (By similarity). Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress (By similarity). Plays a role in insulin sensitivity and glucose homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Increasing Effects of Selective 5-Hydroxytryptamine Type 2C Receptor Stimulation on Evoked Momentary Urethral Closure in Female Rats and Humans., [RefSeq, PubMed]; Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]., [RefSeq]; Serotonin 5-HT2A and 5-HT2C receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms., [RefSeq, PubMed]; Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT2C receptor expression in female rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001587 Gq/11-coupled serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0045202 synapse;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0035095 behavioral response to nicotine;GO:0045600 positive regulation of fat cell differentiation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08909-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35563-1", "uniprot_id": [ { "id": "5HT3A_RAT", "url": "https://www.uniprot.org/uniprot/P35563", "type": "external" } ], "mass": 55428.0, "length": 483, "protein_name": "5-hydroxytryptamine receptor 3A", "gene_name": "Htr3a", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 3A precursor", "refseq_ac": [ { "id": "NP_077370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077370", "type": "external" } ], "gene_names_uniprotkb": "Htr3a; 5ht3; Htr3", "gene_names_refseq": "5-HT3A; 5-HT3; 5HT3; Htr3a; Htr3", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor", "protein_names_refseq": "5-HT-3; 5-HT3 receptor; 5-HT3-A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3A precursor; 5-hydroxytryptamine receptor 3; serotonin receptor 3A; serotonin-gated ion channel receptor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:79246); (R-RNO-112314)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10854267;12151552;32537854;33160048;38285939;7509203", "class_list": "", "function": "FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA in sensory neurons., [RefSeq, PubMed]; Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of 5-HT1A and 5-HT3 receptors in serotonergic activation of sensory neurons in relation to itch and pain behavior in the rat. Erratum:[J Neurosci Res. 2023 Jan;101(1):196. doi: 10.1002/jnr.25137. PMID: 36250251], [RefSeq, PubMed]; Stereological investigation of 5-HT3 receptors in the substantia nigra and dorsal raphe nucleus in the rat., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:0042802 identical protein binding;GO:0051378 serotonin binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0045471 response to ethanol;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0048149 behavioral response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35563-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68511-1", "uniprot_id": [ { "id": "1433F_RAT", "url": "https://www.uniprot.org/uniprot/P68511", "type": "external" } ], "mass": 28212.0, "length": 246, "protein_name": "14-3-3 protein eta", "gene_name": "Ywhah", "organism": "Rat", "refseq_name": "14-3-3 protein eta", "refseq_ac": [ { "id": "NP_037184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037184", "type": "external" } ], "gene_names_uniprotkb": "Ywhah", "gene_names_refseq": "14-3-3e; Ywhah", "protein_names_uniprotkb": "14-3-3 protein eta", "protein_names_refseq": "14-3-3 protein eta-subtype; 14-3-3 protein eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); cholestasis (Disease Ontology:DOID:13580)", "pathway": " (rno:25576); (R-RNO-111447); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-75035)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "1649368;34502162;36980307;38956068;39038022", "class_list": "", "function": "Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3eta. Publication Status: Online-Only, [RefSeq, PubMed]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)., [UniProtKB]; Identification of YWHAH as a Novel Brain-Derived Extracellular Vesicle Marker Post Long-Term Midazolam Exposure during Early Development. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of H9C2 cell hypertrophy by 14-3-3eta via inhibiting glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11576;P70198", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0006713 glucocorticoid catabolic process;GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P68511-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21588-1", "uniprot_id": [ { "id": "5NTD_RAT", "url": "https://www.uniprot.org/uniprot/P21588", "type": "external" } ], "mass": 63969.0, "length": 576, "protein_name": "5'-nucleotidase", "gene_name": "Nt5e", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nt5e; Nt5; Nte", "gene_names_refseq": "", "protein_names_uniprotkb": "5'-nucleotidase; 3.1.3.35; 3.1.3.5; 3.1.3.89; 3.1.3.91; 3.1.3.99; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary arterial and articular multiple calcification syndrome (Disease Ontology:DOID:0111582); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:58813); (R-RNO-196807); (R-RNO-73621); (R-RNO-74259)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1770988;21454685;2148114;2298743", "class_list": "", "function": "Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:1770988). AMP is the preferred substrate but can also hydrolyze CMP and GMP (PubMed:1770988). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Other substrates include IMP, UMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0097060 synaptic membrane", "go_biological_process": "GO:0046032 ADP catabolic process;GO:0046085 adenosine metabolic process;GO:0046889 positive regulation of lipid biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006196 AMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80201-1", "uniprot_id": [ { "id": "ACVR1_RAT", "url": "https://www.uniprot.org/uniprot/P80201", "type": "external" } ], "mass": 57195.0, "length": 509, "protein_name": "Activin receptor type-1", "gene_name": "Acvr1", "organism": "Rat", "refseq_name": "activin receptor type-1 isoform a precursor", "refseq_ac": [ { "id": "NP_077812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077812", "type": "external" } ], "gene_names_uniprotkb": "Acvr1; Acvrlk2", "gene_names_refseq": "Acvr1", "protein_names_uniprotkb": "Activin receptor type-1; 2.7.11.30; ACTR-I; Activin receptor type I; SKR1; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; TSR-I", "protein_names_refseq": "ACTR-I; ALK2-B; SKR1; TGF-B superfamily receptor type I; TSR-I; activin A receptor, type I; activin receptor type I; activin receptor type-1 isoform a precursor; activin receptor type-1; activin type I receptor; serine/threonine-protein kinase receptor R1", "tax_id": 10116, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); severe pre-eclampsia (Disease Ontology:DOID:13129); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); exfoliation syndrome (Disease Ontology:DOID:13641); primary angle-closure glaucoma (Disease Ontology:DOID:1405); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:79558)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26873969;8248234;8395914", "class_list": "", "function": "Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (By similarity). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0048179 activin receptor complex;GO:0070724 BMP receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P80201-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43138-1", "uniprot_id": [ { "id": "APEX1_RAT", "url": "https://www.uniprot.org/uniprot/P43138", "type": "external" } ], "mass": 35538.0, "length": 317, "protein_name": "DNA repair nuclease/redox regulator APEX1", "gene_name": "Apex1", "organism": "Rat", "refseq_name": "DNA repair nuclease/redox regulator APEX1", "refseq_ac": [ { "id": "NP_077062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077062", "type": "external" } ], "gene_names_uniprotkb": "Apex1; Apex; Ape; Ref1", "gene_names_refseq": "APE; Apex1; Apex; REF-1", "protein_names_uniprotkb": "DNA repair nuclease/redox regulator APEX1; 3.1.11.2; 3.1.21.-; AP endonuclease 1; APEN; APEX nuclease; Apurinic-apyrimidinic endonuclease 1; REF-1; Redox factor-1", "protein_names_refseq": "AP endonuclease 1; APEN; APEX nuclease (multifunctional DNA repair enzyme) 1; APEX nuclease 1; DNA repair nuclease/redox regulator APEX1; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; apurinic/apyrimidinic endonuclease 1; redox factor-1", "tax_id": 10116, "disease": "spina bifida (Disease Ontology:DOID:0080016); urinary bladder cancer (Disease Ontology:DOID:11054); severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); cervix carcinoma (Disease Ontology:DOID:2893); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:79116); (R-RNO-110357); (R-RNO-110362); (R-RNO-110373); (R-RNO-5651801); (R-RNO-73930); (R-RNO-73933)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "10631378;11182545;19401441;22673903;28965839;29772245;31432320;36791545;7510394", "class_list": "", "function": "Apurinic/apyrimidinic endonuclease 1 regulates palmitic acid-mediated apoptosis in cardiomyocytes via endoplasmic reticulum stress., [RefSeq, PubMed]; Changes in APE1 expression and sub-cellular distribution are implicated in inflammatory pain mechanisms mediated by APE1 redox functions., [RefSeq, PubMed]; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends., [UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors (By similarity). Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules (By similarity). Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG. Generates staggered nicks in opposite DNA strands resulting in the formation of double-strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (By similarity). Has 3'-5' exodeoxyribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER (By similarity). Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate and 8-oxoguanine) blocking the 3' side of DNA strand breaks (By similarity). Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression (By similarity) (PubMed:19401441). Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB (By similarity). Exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR (By similarity). Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression (By similarity). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance (By similarity). Plays a role in protection from granzyme-mediated cellular repair leading to cell death (By similarity). Binds DNA and RNA. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Our findings provide an insight into the PTEN and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury, which may be through inducing the PINK1/Parkin-mediated mitophagy., [RefSeq, PubMed]; Study shows that genetically enhancing apurinic/apyrimidinic endonuclease expression or treatment with the small molecule, E3330, increases DNA repair., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548N9", "ec_number_list": [ { "id": "3.2.2.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.29", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.21", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.31", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P43138-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK18-1", "uniprot_id": [ { "id": "CIAO3_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK18", "type": "external" } ], "mass": 53167.0, "length": 476, "protein_name": "Cytosolic iron-sulfur assembly component 3", "gene_name": "Ciao3", "organism": "Rat", "refseq_name": "cytosolic iron-sulfur assembly component 3", "refseq_ac": [ { "id": "NP_001013201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013201", "type": "external" } ], "gene_names_uniprotkb": "Ciao3; Narfl", "gene_names_refseq": "Ciao3; Narfl", "protein_names_uniprotkb": "Cytosolic iron-sulfur assembly component 3; Cytosolic Fe-S cluster assembly factor NARFL; IOP1; Iron-only hydrogenase-like protein 1; Nuclear prelamin A recognition factor-like protein", "protein_names_refseq": "IOP1; cytosolic Fe-S cluster assembly factor NARFL; cytosolic iron-sulfur assembly component 3; iron-only hydrogenase-like protein 1; nuclear prelamin A recognition factor-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360496)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0001666 response to hypoxia;GO:0010468 regulation of gene expression;GO:0002244 hematopoietic progenitor cell differentiation;GO:0032364 intracellular oxygen homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0J9-1", "uniprot_id": [ { "id": "ASPDH_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0J9", "type": "external" } ], "mass": 31260.0, "length": 297, "protein_name": "Aspartate dehydrogenase domain-containing protein", "gene_name": "Aspdh", "organism": "Rat", "refseq_name": "aspartate dehydrogenase domain-containing protein", "refseq_ac": [ { "id": "NP_001009643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009643", "type": "external" } ], "gene_names_uniprotkb": "Aspdh", "gene_names_refseq": "Aspdh; RGD1310111", "protein_names_uniprotkb": "Aspartate dehydrogenase domain-containing protein", "protein_names_refseq": "aspartate dehydrogenase domain-containing protein; putative L-aspartate dehydrogenase", "tax_id": 10116, "disease": "", "pathway": " (rno:292875)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033735 aspartate dehydrogenase [NAD(P)+] activity;GO:0050661 NADP binding", "go_cellular_component": "", "go_biological_process": "GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0J9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55926-1", "uniprot_id": [ { "id": "ASIC1_RAT", "url": "https://www.uniprot.org/uniprot/P55926", "type": "external" } ], "mass": 59641.0, "length": 526, "protein_name": "Acid-sensing ion channel 1", "gene_name": "Asic1", "organism": "Rat", "refseq_name": "acid-sensing ion channel 1", "refseq_ac": [ { "id": "NP_077068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077068", "type": "external" } ], "gene_names_uniprotkb": "Asic1; Accn2; Bnac2", "gene_names_refseq": "ASIC; Accn2; Asic1", "protein_names_uniprotkb": "Acid-sensing ion channel 1; ASIC1; ASIC; Acid-sensing ionic channel; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2", "protein_names_refseq": "BNaC2; acid-sensing (proton-gated) ion channel 1; acid-sensing ion channel 1; acid-sensing ionic channel; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2; proton gated cation channel ASIC1", "tax_id": 10116, "disease": "", "pathway": " (rno:79123); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10798398;10829030;11448963;11588175;11588592;11842212;12198124;12947112;15369669;15452199;23034652;23624383;24323786;24695733;26248594;26680001;28320941;28327374;36279671;36463203;36852448;39019215;40712023;9062189;9360943;9707631", "class_list": "", "function": "Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/beta-catenin/c-Myc pathway in rheumatoid arthritis., [RefSeq, PubMed]; DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress., [RefSeq, PubMed]; Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:11448963, PubMed:9062189, PubMed:9360943). Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents (PubMed:12198124, PubMed:9062189, PubMed:9360943). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:11448963, PubMed:9062189, PubMed:9360943). Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines (PubMed:15369669). Modulates neuronal activity in the circuits underlying innate fear (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Has no pH-gated sodium channel activity per se but can associate with other ASICs and regulate their pH-sensitivity., [UniProtKB, PubMed]; IMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of ASIC1 protein in cerebral ischemia-reperfusion., [RefSeq, PubMed]; Permeable to other cations including calcium, lithium and potassium., [UniProtKB, PubMed, PubMed]; pH activation and steady-state inactivation are shifted to more acidic values (PubMed:12198124). Forms channels that are not permeable to calcium as it discrimates stronger between monovalent cations (PubMed:9707631)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 33, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88762;Q91YB8;Q99NA1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0022857 transmembrane transporter activity;GO:0015280 ligand-gated sodium channel activity;GO:0022839 monoatomic ion-gated channel activity;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007613 memory;GO:0008306 associative learning;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P55926-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJQ0-1", "uniprot_id": [ { "id": "COQ8A_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJQ0", "type": "external" } ], "mass": 72226.0, "length": 649, "protein_name": "Atypical kinase COQ8A, mitochondrial", "gene_name": "Coq8a", "organism": "Rat", "refseq_name": "atypical kinase COQ8A, mitochondrial", "refseq_ac": [ { "id": "NP_001013203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013203", "type": "external" } ], "gene_names_uniprotkb": "Coq8a; Adck3; Cabc1", "gene_names_refseq": "Adck3; Cabc1; Coq8a", "protein_names_uniprotkb": "Atypical kinase COQ8A, mitochondrial; 2.7.-.-; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3", "protein_names_refseq": "aarF domain containing kinase 3; aarF domain-containing protein kinase 3; atypical kinase ADCK3, mitochondrial; atypical kinase COQ8A, mitochondrial; chaperone activity of bc1 complex-like, mitochondrial; chaperone, ABC1 activity of bc1 complex like; coenzyme Q protein 8A", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 4 (Disease Ontology:DOID:0070241); nephrotic syndrome type 9 (Disease Ontology:DOID:0080391); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (rno:360887); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20580948;27213235", "class_list": "", "function": "Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (By similarity). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that CABC1 is an important candidate for mutation analysis in progressive cerebellar ataxia and atrophy on MRI to identify those patients who may benefit from CoQ10 treatment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0043531 ADP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0016310 phosphorylation;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5BJQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08406-1", "uniprot_id": [ { "id": "CNTFR_RAT", "url": "https://www.uniprot.org/uniprot/Q08406", "type": "external" } ], "mass": 40822.0, "length": 372, "protein_name": "Ciliary neurotrophic factor receptor subunit alpha", "gene_name": "Cntfr", "organism": "Rat", "refseq_name": "ciliary neurotrophic factor receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_001003929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003929", "type": "external" } ], "gene_names_uniprotkb": "Cntfr", "gene_names_refseq": "CNTFR-alpha; Cntfr", "protein_names_uniprotkb": "Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR-alpha", "protein_names_refseq": "CNTF receptor subunit alpha; CNTFR alpha; ciliary neurotrophic factor receptor alpha; ciliary neurotrophic factor receptor subunit alpha precursor; ciliary neurotrophic factor receptor subunit alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:313173); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "22146310;23325260;25799580;30861131;31185137;8381290;8460125", "class_list": "", "function": "Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha., [RefSeq, PubMed]; Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H) transduction of dopaminergic neurons Erratum:[PLoS One. 2015 Apr 17;10(4):e0126450. doi: 10.1371/journal.pone.0126450. PMID: 25886143] Publication Status: Online-Only, [RefSeq, PubMed]; Binds to CNTF. The alpha subunit provides the receptor specificity., [UniProtKB, UniProtKB, UniProtKB]; Compared with the EAE group, luteolin-treated EAE group showed upregulation of CNTF expression and significant increase in cAMP and TAC levels, while it showed significant decrease in cleaved caspase 3, NF-kappaB, and MIP-1alpha levels., [RefSeq, PubMed]; Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1) (PubMed:8381290). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation. Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR. Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (By similarity)., [UniProtKB, UniProtKB, PubMed]; The data strongly suggested that intracellular ciliary neurotrophic factor may directly modulate proopiomelanocortin gene expression via the activation of ciliary neurotrophic factor receptors in the cell nucleus., [RefSeq, PubMed]; The data suggest that endogenous CNTF receptor signaling in type B stem cells inhibits adult neurogenesis, and further suggest that the regulation may occur in a neuron subtype-specific manner., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0005102 signaling receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0003360 brainstem development;GO:0060538 skeletal muscle organ development;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0001967 suckling behavior", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08406-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22063-1", "uniprot_id": [ { "id": "CNTN2_RAT", "url": "https://www.uniprot.org/uniprot/P22063", "type": "external" } ], "mass": 113043.0, "length": 1040, "protein_name": "Contactin-2", "gene_name": "Cntn2", "organism": "Rat", "refseq_name": "contactin-2 precursor", "refseq_ac": [ { "id": "NP_037016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037016", "type": "external" } ], "gene_names_uniprotkb": "Cntn2; Tax1", "gene_names_refseq": "Cntn2; TAG-1; TAG-564; TAG1; Tax", "protein_names_uniprotkb": "Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; TAX-1; Transient axonal glycoprotein 1", "protein_names_refseq": "TAX-1; axonal glycoprotein TAG-1; axonin-1; contactin 2 (axonal); contactin-2 precursor; transient axonal glycoprotein 1", "tax_id": 10116, "disease": "familial adult myoclonic epilepsy 5 (Disease Ontology:DOID:0111691); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); endometrial adenocarcinoma (Disease Ontology:DOID:2870); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); dermoid cyst of ovary (Disease Ontology:DOID:5117); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); rheumatoid arthritis (Disease Ontology:DOID:7148); lung disease (Disease Ontology:DOID:850); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25356)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1039/D0MO00044B;2317872;24090084;26722394;30078168;33044326;34106099", "class_list": "", "function": "May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region (By similarity)., [UniProtKB]; MiR-34a regulates Schwann cell proliferation and migration by targeting CNTN2., [RefSeq, PubMed]; RT-PCR and Western blotting methods showed that 20 muM Abeta25-35 could increase the expression levels of TAG1, APP, AICD and p53 (P<0.01) while they decreased in BMSCs + Abeta25-35 group Publication Status: Online-Only, [RefSeq, PubMed]; The biological effects of miR-3075 on Schwann cell phenotype might by through the negative regulation of contactin 2, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 12, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0098632 cell-cell adhesion mediator activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043209 myelin sheath", "go_biological_process": "GO:0007409 axonogenesis;GO:0007612 learning;GO:0022010 central nervous system myelination;GO:0031175 neuron projection development;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P22063-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51799-1", "uniprot_id": [ { "id": "CLCN7_RAT", "url": "https://www.uniprot.org/uniprot/P51799", "type": "external" } ], "mass": 88731.0, "length": 803, "protein_name": "H(+)/Cl(-) exchange transporter 7", "gene_name": "Clcn7", "organism": "Rat", "refseq_name": "H(+)/Cl(-) exchange transporter 7", "refseq_ac": [ { "id": "NP_113756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113756", "type": "external" } ], "gene_names_uniprotkb": "Clcn7", "gene_names_refseq": "ClC-7; Clcn7", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 7; chloride channel 7 alpha subunit; chloride channel protein 7; chloride channel, voltage-sensitive 7; chloride voltage-gated channel 7", "tax_id": 10116, "disease": "autosomal dominant osteopetrosis 2 (Disease Ontology:DOID:0110938); autosomal recessive osteopetrosis 4 (Disease Ontology:DOID:0110944); osteopetrosis (Disease Ontology:DOID:13533); lysosomal storage disease (Disease Ontology:DOID:3211)", "pathway": " (rno:29233); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16222710;18449189;20830208;32976885;8543009", "class_list": "", "function": "Chloride channel 7 protects from redox status impairment-induced renal tubular epithelial cell apoptosis by activating autophagy., [RefSeq, PubMed]; G213R mutation prevents ClC-7 from being correctly targeted to the lysosomal membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:18449189). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0062158 chloride:proton antiporter activity;GO:0005254 chloride channel activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0034707 chloride channel complex;GO:0016020 membrane", "go_biological_process": "GO:0009268 response to pH;GO:1902476 chloride transmembrane transport;GO:0030321 transepithelial chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51799-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51802-1", "uniprot_id": [ { "id": "CLCKB_RAT", "url": "https://www.uniprot.org/uniprot/P51802", "type": "external" } ], "mass": 75218.0, "length": 687, "protein_name": "Chloride channel protein ClC-Kb", "gene_name": "Clcnkb", "organism": "Rat", "refseq_name": "chloride channel protein ClC-Kb", "refseq_ac": [ { "id": "NP_775126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775126", "type": "external" } ], "gene_names_uniprotkb": "Clcnkb", "gene_names_refseq": "ClC-K2L; Clck2; Clcnk1l; Clcnkb", "protein_names_uniprotkb": "Chloride channel protein ClC-Kb; Chloride channel Kb; ClC-K2", "protein_names_refseq": "chloride channel K2; chloride channel Kb; chloride channel protein ClC-Kb; chloride channel, voltage-sensitive Kb; clC-K2", "tax_id": 10116, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); hypertension (Disease Ontology:DOID:10763); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (rno:79430); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12111250;12761627;18480177;27748841;8021279;8041726", "class_list": "", "function": "Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. May conduct double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (By similarity). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain and functional switch to the ion conducting state. CLCNKB:BSND channels display mostly a linear current-voltage relationship controlled by common gate (By similarity). Mediates chloride conductance along nephron segments, namely the thick ascending limb of Henle's loop, convoluted tubule and the collecting duct, contributing to the maintenance of systemic acid-base and electrolyte homeostasis (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In salt-sensitive hypertension, there is a strong upregulation, both of NCC and ClC-K along the distal convoluted tubules, which explains the persistence of hypertension., [RefSeq, PubMed]; The present study showed that adenosine affected the mRNA expression of CLCNKB, initially through the cAMPPKA pathway and then the PLA2AA pathway., [RefSeq, PubMed]; This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 5. This gene is syntenic with human CLCNKA (geneID:1187).[provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:0070293 renal absorption;GO:0051453 regulation of intracellular pH;GO:0030321 transepithelial chloride transport;GO:0070294 renal sodium ion absorption", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51802-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51796-1", "uniprot_id": [ { "id": "CLCN5_RAT", "url": "https://www.uniprot.org/uniprot/P51796", "type": "external" } ], "mass": 90687.0, "length": 816, "protein_name": "H(+)/Cl(-) exchange transporter 5", "gene_name": "Clcn5", "organism": "Rat", "refseq_name": "H(+)/Cl(-) exchange transporter 5 isoform 1", "refseq_ac": [ { "id": "NP_001401322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401322", "type": "external" } ], "gene_names_uniprotkb": "Clcn5", "gene_names_refseq": "CLC5; Clcn5", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; Chloride transporter ClC-5; ClC-5", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 5 isoform 1; chloride channel 5; chloride channel protein 5; chloride channel, voltage-sensitive 5; chloride transporter ClC-5; chloride voltage-gated channel 5; clC-5; h(+)/Cl(-) exchange transporter 5", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); X-linked recessive hypophosphatemic rickets (Disease Ontology:DOID:0080353); Dent disease 1 (Disease Ontology:DOID:0081453); X-linked nephrolithiasis type I (Disease Ontology:DOID:0111798); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533); renal tubular transport disease (Disease Ontology:DOID:447); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:25749); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12475763;19261613;21063094;25587118;8537381;8626585", "class_list": "", "function": "ClC-5 chloride-proton exchangers by siRNA-mediated silencing are important modulators of H+-ATPase function in immortalized rat renal proximal tubule cells., [RefSeq, PubMed]; ClC-5 is expressed exclusively in H(+)-ATPase-rich cells (narrow and clear cells). ClC-5 also partially colocalizes with the H(+)-ATPase in the subapical pole of clear cells in the epididymis., [RefSeq, PubMed]; Identified another key molecular component of the albumin endocytic machinery in the renal proximal tubule and describe a new role for aspartyl aminopeptidase in stabilizing the actin cytoskeleton, [RefSeq, PubMed]; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K839;P70642", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006821 chloride transport;GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51796-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35524-1", "uniprot_id": [ { "id": "CLCN1_RAT", "url": "https://www.uniprot.org/uniprot/P35524", "type": "external" } ], "mass": 110073.0, "length": 994, "protein_name": "Chloride channel protein 1", "gene_name": "Clcn1", "organism": "Rat", "refseq_name": "chloride channel protein 1", "refseq_ac": [ { "id": "NP_037279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037279", "type": "external" } ], "gene_names_uniprotkb": "Clcn1", "gene_names_refseq": "Clcn1; SMCC", "protein_names_uniprotkb": "Chloride channel protein 1; Chloride channel protein, skeletal muscle; ClC-1", "protein_names_refseq": "chloride channel 1, skeletal muscle; chloride channel protein 1; chloride channel protein, skeletal muscle; chloride channel, voltage-sensitive 1; clC-1", "tax_id": 10116, "disease": "Becker disease (Disease Ontology:DOID:0081335); Thomsen disease (Disease Ontology:DOID:0081336); myotonia congenita (Disease Ontology:DOID:2106); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:25688); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1659664;19220292;19786584;22673903;9565403", "class_list": "", "function": "Regulation of ClC-1 in action potential-firing fast-twitch muscle fibers Erratum:[J Gen Physiol. 2009 Dec;134(6):523. de Paoli, Frank Vinzenco [corrected to de Paoli, Frank Vincenzo]], [RefSeq, PubMed]; Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression., [RefSeq, PubMed]; Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (By similarity) (PubMed:1659664, PubMed:9565403). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (By similarity). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:1659664, PubMed:9565403)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005247 voltage-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0034707 chloride channel complex;GO:0030315 T-tubule", "go_biological_process": "GO:0006936 muscle contraction;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0019227 neuronal action potential propagation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35524-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97527-1", "uniprot_id": [ { "id": "CNTN5_RAT", "url": "https://www.uniprot.org/uniprot/P97527", "type": "external" } ], "mass": 120603.0, "length": 1099, "protein_name": "Contactin-5", "gene_name": "Cntn5", "organism": "Rat", "refseq_name": "contactin-5 precursor", "refseq_ac": [ { "id": "NP_446198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446198", "type": "external" } ], "gene_names_uniprotkb": "Cntn5", "gene_names_refseq": "Cntn5; Nb-2", "protein_names_uniprotkb": "Contactin-5; Neural recognition molecule NB-2", "protein_names_refseq": "contactin-5 precursor; neural recognition molecule NB-2", "tax_id": 10116, "disease": "", "pathway": " (rno:114589); (R-RNO-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11438979;19177518;38843836;8945756", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system., [UniProtKB, PubMed]; Findings suggest that NB-2 plays a key role in maturation of glutamatergic synapses in the brainstem during the final stages of auditory development, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0042734 presynaptic membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97527-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505I4-1", "uniprot_id": [ { "id": "CO040_RAT", "url": "https://www.uniprot.org/uniprot/Q505I4", "type": "external" } ], "mass": 13288.0, "length": 126, "protein_name": "UPF0235 protein C15orf40 homolog", "gene_name": "C1h15orf40; ENSRNOG00000069610", "organism": "Rat", "refseq_name": "UPF0235 protein C15orf40 homolog isoform 1", "refseq_ac": [ { "id": "NP_001019920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019920", "type": "external" } ], "gene_names_uniprotkb": "C1h15orf40; ENSRNOG00000069610; C1h15orf40-ps2; LOC134479259", "gene_names_refseq": "C1h15orf40; RGD1305713", "protein_names_uniprotkb": "UPF0235 protein C15orf40 homolog", "protein_names_refseq": "UPF0235 protein C15orf40 homolog isoform 1; UPF0235 protein C15orf40 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:293059)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q505I4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37397-1", "uniprot_id": [ { "id": "CNN3_RAT", "url": "https://www.uniprot.org/uniprot/P37397", "type": "external" } ], "mass": 36435.0, "length": 330, "protein_name": "Calponin-3", "gene_name": "Cnn3", "organism": "Rat", "refseq_name": "calponin-3", "refseq_ac": [ { "id": "NP_062232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062232", "type": "external" } ], "gene_names_uniprotkb": "Cnn3", "gene_names_refseq": "Cnn3", "protein_names_uniprotkb": "Calponin-3; Calponin, acidic isoform; Calponin, non-muscle isoform", "protein_names_refseq": "acidic calponin h3; calponin 3, acidic; calponin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:54321)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12564930;16358313;20181831;8144658", "class_list": "", "function": "Acidic calponin is a key factor in the regulation of spine plasticity and synaptic activity, [RefSeq, PubMed]; Calponin undergoes a concomitant binding to both F-actin and microtubules by interaction at the former site with actin and at the second site with microtubules, [RefSeq, PubMed]; H3/acidic calponin controls fibroblast migration by regulation of ERK1/2-mediated l-caldesmon phosphorylation., [RefSeq, PubMed]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005884 actin filament;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030855 epithelial cell differentiation;GO:0031032 actomyosin structure organization;GO:0032780 negative regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P37397-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08290-1", "uniprot_id": [ { "id": "CNN1_RAT", "url": "https://www.uniprot.org/uniprot/Q08290", "type": "external" } ], "mass": 33344.0, "length": 297, "protein_name": "Calponin-1", "gene_name": "Cnn1", "organism": "Rat", "refseq_name": "calponin-1", "refseq_ac": [ { "id": "NP_113935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113935", "type": "external" } ], "gene_names_uniprotkb": "Cnn1", "gene_names_refseq": "Cnn1", "protein_names_uniprotkb": "Calponin-1; Basic calponin; Calponin H1, smooth muscle", "protein_names_refseq": "basic calponin; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; calponin H1, smooth muscle; calponin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:65204)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11973344;12716472;22673903;27531060;28374979;28457943;30339939;8359698;8508530", "class_list": "", "function": "Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity., [RefSeq, PubMed]; CNh1 plays a role as tumor suppressor in SR-3Y1 mainly by decreasing VEGF expression and angiogenesis in vivo and partially through reducing cellular proliferative potential and cell motility, [RefSeq, PubMed]; Data suggest that proteolysis of calponin-1 by Mmp2 (matrix metallopeptidase 2) contributes to the down-regulation of calponin-1 in cytoplasm of endothelium and smooth muscle of aorta/arteries in early (1-week) hypertension; however, at 2-weeks, calponin-1 is up-regulated., [RefSeq, PubMed]; MMP-2 activity is increased in both conductance and resistance arteries in hypertension and contributes to early vascular dysfunction and remodelling. These maladaptive effects were related to the divergent regulation of calponin-1, which is decreased in aortas while is increased in resistance arteries., [RefSeq, PubMed]; Oxidative stress may contribute to the increase in aortic MMP-2 activity, possibly by S-glutathiolation, and this may result in calponin-1 loss and maladaptive vascular remodeling in early hypertension., [RefSeq, PubMed]; The molecular basis for the autoregulation of calponin by isoform-specific C-terminal tail sequences, [RefSeq, PubMed]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0031032 actomyosin structure organization;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q08290-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PZ9-1", "uniprot_id": [ { "id": "YJU2B_RAT", "url": "https://www.uniprot.org/uniprot/Q32PZ9", "type": "external" } ], "mass": 43800.0, "length": 385, "protein_name": "Probable splicing factor YJU2B", "gene_name": "Yju2b", "organism": "Rat", "refseq_name": "probable splicing factor YJU2B", "refseq_ac": [ { "id": "NP_001032733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032733", "type": "external" } ], "gene_names_uniprotkb": "Yju2b; Ccdc130", "gene_names_refseq": "Ccdc130; RGD1307598; Yju2b", "protein_names_uniprotkb": "Probable splicing factor YJU2B; Coiled-coil domain-containing protein 130", "protein_names_refseq": "coiled-coil domain containing 130; coiled-coil domain-containing protein 130; probable splicing factor YJU2B", "tax_id": 10116, "disease": "", "pathway": " (rno:304656)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0071014 post-mRNA release spliceosomal complex;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0009615 response to virus;GO:0045292 mRNA cis splicing, via spliceosome;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PZ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61212-1", "uniprot_id": [ { "id": "ARL1_RAT", "url": "https://www.uniprot.org/uniprot/P61212", "type": "external" } ], "mass": 20412.0, "length": 181, "protein_name": "ADP-ribosylation factor-like protein 1", "gene_name": "Arl1", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 1", "refseq_ac": [ { "id": "NP_071780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071780", "type": "external" } ], "gene_names_uniprotkb": "Arl1; Arf7", "gene_names_refseq": "Arl1", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 1", "protein_names_refseq": "ADP-ribosylation factor like GTPase 1; ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64187); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11792819;12972563;14718928;8195219", "class_list": "", "function": "Crystal structure of Arl1-GTP in complex with the GRIP domain of golgin-245 shows that Arl1-GTP interacts with the GRIP domain predominantly in a hydrophobic manner, with the switch II region conferring the main recognition surface, [RefSeq, PubMed]; GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex. Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GTP-binding protein. Can activate phospholipase D with very low efficiency (By similarity). Important for normal function of the Golgi apparatus., [UniProtKB, PubMed, PubMed]; Morphological and biochemical evidence shows that Arl1 is enriched at the trans site of the Golgi, marked by AP-1, is saturable in intact cells, dependent on N-terminal myristoylation and is necessary to maintain normal Golgi structure and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P41276", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008047 enzyme activator activity;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0009404 toxin metabolic process;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61212-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51792-1", "uniprot_id": [ { "id": "CLCN3_RAT", "url": "https://www.uniprot.org/uniprot/P51792", "type": "external" } ], "mass": 90855.0, "length": 818, "protein_name": "H(+)/Cl(-) exchange transporter 3", "gene_name": "Clcn3", "organism": "Rat", "refseq_name": "H(+)/Cl(-) exchange transporter 3 isoform 1", "refseq_ac": [ { "id": "NP_445815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445815", "type": "external" } ], "gene_names_uniprotkb": "Clcn3", "gene_names_refseq": "ClC-3; Clcn3", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 3; Chloride channel protein 3; Chloride transporter ClC-3; ClC-3", "protein_names_refseq": "H(+)/Cl(-) exchange transporter 3 isoform 1; chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; chloride voltage-gated channel 3; h(+)/Cl(-) exchange transporter 3; protein kinase C-regulated chloride channel", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (rno:84360)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10915634;16222710;29158167;29527534;30025794;30468668;32247607;8155321", "class_list": "", "function": "A chloride channel in rat pancreatic acinar AR42J cells is sensitive to extracellular acidification and dependent on ROS., [RefSeq, PubMed]; Data suggest that the chloride channel-3 (CLC-3) might be modulated by transforming growth factor beta (TGF-beta) / TGF-beta Receptor II (TGF- beta RII) signaling pathway during the development of diabetic encephalopathy (DE). Publication Status: Online-Only, [RefSeq, PubMed]; Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo., [RefSeq, PubMed]; Knockdown of CLC-3 in hippocampal CA1 significantly attenuates the contextual fear memory, reduces spine density, induces defects of excitatory synaptic ultrastructure showed by the decreased PSD length, PSD thickness and active zone length, and impairs L-LTP induction and maintenance, and induces the synaptic NMDAR subunit composition to an increased GluN2A/GluN2B ratio pattern and reduces the activity of CaMKII-alpha., [RefSeq, PubMed]; Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy., [RefSeq, PubMed]; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9R287", "ec_number_list": [], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005216 monoatomic ion channel activity;GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006911 phagocytosis, engulfment;GO:0008344 adult locomotory behavior;GO:0070050 neuron cellular homeostasis;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51792-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B2-1", "uniprot_id": [ { "id": "DCNL3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B2", "type": "external" } ], "mass": 34350.0, "length": 304, "protein_name": "DCN1-like protein 3", "gene_name": "Dcun1d3", "organism": "Rat", "refseq_name": "DCN1-like protein 3", "refseq_ac": [ { "id": "NP_001020057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020057", "type": "external" } ], "gene_names_uniprotkb": "Dcun1d3", "gene_names_refseq": "DCNL3; Dcun1d3; RGD1308893", "protein_names_uniprotkb": "DCN1-like protein 3; DCNL3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3", "protein_names_refseq": "DCN1, defective in cullin neddylation 1, domain containing 3; DCN1-like protein 3; DCUN1 domain-containing protein 3; defective in cullin neddylation protein 1-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:309035); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032182 ubiquitin-like protein binding;GO:0097602 cullin family protein binding;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0010332 response to gamma radiation;GO:0043065 positive regulation of apoptotic process;GO:0030308 negative regulation of cell growth;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:2000435 negative regulation of protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8B2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10608-1", "uniprot_id": [ { "id": "ADRB2_RAT", "url": "https://www.uniprot.org/uniprot/P10608", "type": "external" } ], "mass": 46891.0, "length": 418, "protein_name": "Beta-2 adrenergic receptor", "gene_name": "Adrb2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adrb2; Adrb2r", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); childhood-onset asthma (Disease Ontology:DOID:0080815); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); Graves' disease (Disease Ontology:DOID:12361); dilated cardiomyopathy (Disease Ontology:DOID:12930); familial hypercholesterolemia (Disease Ontology:DOID:13810); interstitial cystitis (Disease Ontology:DOID:13949); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); dermatitis (Disease Ontology:DOID:2723); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); myasthenia gravis (Disease Ontology:DOID:437); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); ulcerative colitis (Disease Ontology:DOID:8577); psoriasis (Disease Ontology:DOID:8893); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-390696); (R-RNO-418555); (R-RNO-5689880); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "2155412;23166351;2825184;29393594;7590294;8597598", "class_list": "", "function": "G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE) (By similarity). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway. ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (By similarity). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6LCR3", "ec_number_list": [], "go_molecular_function": "GO:0031713 B2 bradykinin receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005634 nucleus;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0003059 positive regulation of the force of heart contraction by epinephrine;GO:0001889 liver development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10608-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29418-1", "uniprot_id": [ { "id": "ATP5E_RAT", "url": "https://www.uniprot.org/uniprot/P29418", "type": "external" } ], "mass": 5767.0, "length": 51, "protein_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "gene_name": "Atp5f1e", "organism": "Rat", "refseq_name": "ATP synthase F(1) complex subunit epsilon, mitochondrial", "refseq_ac": [ { "id": "NP_620799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620799", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1e; Atp5e", "gene_names_refseq": "Atp5e; Atp5f1e", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase F1 subunit epsilon; ATPase subunit epsilon", "protein_names_refseq": "ATP synthase F(1) complex subunit epsilon, mitochondrial; ATP synthase subunit epsilon, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit; ATPase subunit epsilon", "tax_id": 10116, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 3 (Disease Ontology:DOID:0060332)", "pathway": " (rno:245958); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1429613;17575325;26446791;29393594", "class_list": "", "function": "Subunit epsilon, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P29418-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80225-1", "uniprot_id": [ { "id": "B4GT1_RAT", "url": "https://www.uniprot.org/uniprot/P80225", "type": "external" } ], "mass": 3137.0, "length": 32, "protein_name": "Beta-1,4-galactosyltransferase 1", "gene_name": "B4galt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "B4galt1; Ggtb2", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 1; 2.4.1.-; 2.4.1.22; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 1; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T1; Lactose synthase A protein; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1; b4Gal-T1", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IId (Disease Ontology:DOID:0070256); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (rno:24390)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8375379", "class_list": "glycogene;glycosyltransferase", "function": "Galactosyltransferase acting in the Golgi stacks. Catalyzes the transfer of galactose (Gal) from UDP-alpha-D-galactose in beta(1->4) linkage to the non-reducing terminal N-acetylglucosamine (GlcNAc) moieties of glycolipids and complex-type N-linked glycans (By similarity). Adds one Gal residue to both GlcNAc beta(1->2)-linked to the alpha(1->3) and alpha(1->6) mannose antennae of complex-type N-glycans, enabling the formation of mono- and di-galactosylated glycoforms (By similarity). Galactosylates complex-type N-glycans attached on the fragment crystallizable (Fc) of immunoglobulin-gamma isotypes (IgGs), a prerequisite for antibody glycan sialylation and related anti-inflammatory effector functions (By similarity). Can also transfer a Gal residue to free GlcNAc to form N-acetyllactosamine (By similarity). With LALBA/alpha-lactalbumin forms the lactose synthase complex responsible for production of large amounts of lactose in the lactating mammary gland. Interaction with LALBA alters the sugar substrate specificity of the catalytic domain, enabling high affinity binding of glucose and its transformation to lactose (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0043236 laminin binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008285 negative regulation of cell population proliferation;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 10444, "hit_score": 0.2, "record_id": "P80225-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51882-1", "uniprot_id": [ { "id": "CD5_RAT", "url": "https://www.uniprot.org/uniprot/P51882", "type": "external" } ], "mass": 53440.0, "length": 491, "protein_name": "T-cell surface glycoprotein CD5", "gene_name": "Cd5", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD5 precursor", "refseq_ac": [ { "id": "NP_062168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062168", "type": "external" } ], "gene_names_uniprotkb": "Cd5; LOC100911215", "gene_names_refseq": "Cd5", "protein_names_uniprotkb": "T-cell surface glycoprotein CD5", "protein_names_refseq": "CD5 antigen; Lymphocyte antigen CD5; T-cell surface glycoprotein CD5 precursor; T-cell surface glycoprotein CD5-like; T-cell surface glycoprotein CD5", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 63 (Disease Ontology:DOID:0080426); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:54236)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21745657;22673903;7510236", "class_list": "", "function": "Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28., [RefSeq, PubMed]; Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (By similarity). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63098", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0097190 apoptotic signaling pathway;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51882-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58365-1", "uniprot_id": [ { "id": "CAD23_RAT", "url": "https://www.uniprot.org/uniprot/P58365", "type": "external" } ], "mass": 365455.0, "length": 3317, "protein_name": "Cadherin-23", "gene_name": "Cdh23", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdh23", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-23; Otocadherin", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 12 (Disease Ontology:DOID:0110467); Usher syndrome type 1D (Disease Ontology:DOID:0110831); pituitary adenoma 5 (Disease Ontology:DOID:0112008)", "pathway": " (rno:114102)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11597768", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 42, "predicted_n_glycosites": 42, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 42, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0045177 apical part of cell;GO:0045202 synapse", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58365-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLY0-1", "uniprot_id": [ { "id": "CEP63_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLY0", "type": "external" } ], "mass": 62680.0, "length": 538, "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "Cep63", "organism": "Rat", "refseq_name": "centrosomal protein of 63 kDa isoform 1 precursor", "refseq_ac": [ { "id": "NP_001032861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032861", "type": "external" } ], "gene_names_uniprotkb": "Cep63", "gene_names_refseq": "Cep63", "protein_names_uniprotkb": "Centrosomal protein of 63 kDa; Cep63", "protein_names_refseq": "centrosomal protein 63kDa; centrosomal protein of 63 kDa isoform 1 precursor; centrosomal protein of 63 kDa", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); Seckel syndrome 6 (Disease Ontology:DOID:0070006)", "pathway": " (rno:300963); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0051301 cell division;GO:0050821 protein stabilization;GO:0042770 signal transduction in response to DNA damage;GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLY0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2IBC5-1", "uniprot_id": [ { "id": "CAV2_RAT", "url": "https://www.uniprot.org/uniprot/Q2IBC5", "type": "external" } ], "mass": 18266.0, "length": 162, "protein_name": "Caveolin-2", "gene_name": "Cav2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cav2", "gene_names_refseq": "", "protein_names_uniprotkb": "Caveolin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); primary open angle glaucoma (Disease Ontology:DOID:1070); low tension glaucoma (Disease Ontology:DOID:13544); high grade glioma (Disease Ontology:DOID:3070); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:363425); (R-RNO-9009391)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11883949;12917688;16645331;19427337;19778377;29393594", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression., [UniProtKB, PubMed, PubMed]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6R8;Q8VIK7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0043410 positive regulation of MAPK cascade;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2IBC5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47820-1", "uniprot_id": [ { "id": "ACE_RAT", "url": "https://www.uniprot.org/uniprot/P47820", "type": "external" } ], "mass": 150908.0, "length": 1313, "protein_name": "Angiotensin-converting enzyme", "gene_name": "Ace", "organism": "Rat", "refseq_name": "angiotensin-converting enzyme precursor", "refseq_ac": [ { "id": "NP_036676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036676", "type": "external" } ], "gene_names_uniprotkb": "Ace; Dcp1", "gene_names_refseq": "Ace; CD143; Dcp1; StsRR92", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 3.4.15.1; ACE; Dipeptidyl carboxypeptidase I; Kininase II", "protein_names_refseq": "Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); angiotensin 1 converting enzyme 1; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme precursor; angiotensin-converting enzyme-like; angiotensin-converting enzyme; dipeptidyl carboxypeptidase I; kininase II", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoidosis (Disease Ontology:DOID:11335); pyelonephritis (Disease Ontology:DOID:11400); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); leukemia (Disease Ontology:DOID:1240); hepatitis A (Disease Ontology:DOID:12549); endomyocardial fibrosis (Disease Ontology:DOID:12932); leukostasis (Disease Ontology:DOID:12986); uveitis (Disease Ontology:DOID:13141); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); cholestasis (Disease Ontology:DOID:13580); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung carcinoma (Disease Ontology:DOID:3905); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); mitral valve disease (Disease Ontology:DOID:61); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); ocular hypotension (Disease Ontology:DOID:790); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); polycythemia (Disease Ontology:DOID:8432); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); diastolic heart failure (Disease Ontology:DOID:9775); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24310); (R-RNO-2022377)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12500972;12963491;15671045;16641100;18077343;20487892;22673903;24090084;35969203;37052403;8292044", "class_list": "", "function": "ACE and ACE2 catalytic activity in the fecal content along the gut., [RefSeq, PubMed]; Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity (By similarity). Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates (By similarity). Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin (By similarity). Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response (By similarity). Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins (By similarity). Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (PubMed:20487892). Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin (By similarity). Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) (PubMed:12500972, PubMed:18077343). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343). Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation (By similarity). Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones (By similarity). Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Increasing angiotensin-converting enzyme 1 regulated by histone 3 lysine 27 hyperacetylation in high-fat diet-induced hypertensive rat kidney., [RefSeq, PubMed]; Isoform produced by alternative promoter usage that is specifically expressed in spermatocytes and adult testis, and which is required for male fertility. In contrast to somatic isoforms, only contains one catalytic domain. Acts as a dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of substrates (By similarity). The identity of substrates that are needed for male fertility is unknown. May also have a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. The GPIase activity was reported to be essential for the egg-binding ability of the sperm. This activity is however unclear and has been challenged by other groups, suggesting that it may be indirect (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 85, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMC6;Q8CFN1;Q9EQM9", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.15.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.15.1", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005516 calmodulin binding;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0090281 negative regulation of calcium ion import;GO:0007283 spermatogenesis;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P47820-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70584-1", "uniprot_id": [ { "id": "ACDSB_RAT", "url": "https://www.uniprot.org/uniprot/P70584", "type": "external" } ], "mass": 47824.0, "length": 432, "protein_name": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadsb", "organism": "Rat", "refseq_name": "short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_037216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037216", "type": "external" } ], "gene_names_uniprotkb": "Acadsb", "gene_names_refseq": "Acadsb", "protein_names_uniprotkb": "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; 1.3.8.5; 2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; SBCAD", "protein_names_refseq": "2-MEBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; 2-methylbutyryl-coenzyme A dehydrogenase; Acyl-Coenzyme A dehydrogenase short-branched chain; SBCAD; acyl-Coenzyme A dehydrogenase, short/branched chain; short/branched chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:25618); (R-RNO-70895); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12855692;23474214;6874697;8660691", "class_list": "", "function": "Differences between the rat and human enzyme at positions 383, 222, and 220 alter substrate specificity without affecting substrate binding., [RefSeq, PubMed]; Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:12855692, PubMed:6874697, PubMed:8660691). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA) (PubMed:12855692, PubMed:6874697, PubMed:8660691). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway (By similarity). Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug (PubMed:8660691)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Short/branched chain acyl-CoA dehydrogenase has its catalytic properties relatively similar to those of straight-chain acyl-CoA dehydrogenases in terms of their isomerase activity and enzyme inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0009055 electron transfer activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006637 acyl-CoA metabolic process;GO:0006550 L-isoleucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70584-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BMD4-1", "uniprot_id": [ { "id": "DEPP_RAT", "url": "https://www.uniprot.org/uniprot/Q5BMD4", "type": "external" } ], "mass": 22776.0, "length": 205, "protein_name": "Protein DEPP", "gene_name": "Depp1; Depp", "organism": "Rat", "refseq_name": "protein DEPP", "refseq_ac": [ { "id": "NP_001019505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019505", "type": "external" } ], "gene_names_uniprotkb": "Depp1; Depp; LOC500300", "gene_names_refseq": "Depp1; Depp", "protein_names_uniprotkb": "Protein DEPP", "protein_names_refseq": "DEPP1, autophagy regulator; decidual protein induced by progesterone; protein DEPP", "tax_id": 10116, "disease": "", "pathway": " (rno:500300)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in autophagy., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQM5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0010506 regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BMD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56932-1", "uniprot_id": [ { "id": "2ABD_RAT", "url": "https://www.uniprot.org/uniprot/P56932", "type": "external" } ], "mass": 51982.0, "length": 453, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "gene_name": "Ppp2r2d", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "refseq_ac": [ { "id": "NP_653347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653347", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r2d", "gene_names_refseq": "Ppp2r2d", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform", "tax_id": 10116, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (rno:246255)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10556517;19029245", "class_list": "", "function": "Select PP2A heterotrimers oppose desensitization of the TrkA receptor tyrosine kinase, perhaps through dephosphorylation of inhibitory Ser/Thr phosphorylation sites on the receptor itself., [RefSeq, PubMed]; Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HR7", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56932-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27364-1", "uniprot_id": [ { "id": "3BHS5_RAT", "url": "https://www.uniprot.org/uniprot/P27364", "type": "external" } ], "mass": 42206.0, "length": 373, "protein_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b5", "gene_name": "Hsd3b5", "organism": "Rat", "refseq_name": "NADPH-dependent 3-keto-steroid reductase Hsd3b5", "refseq_ac": [ { "id": "NP_036716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036716", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b5; Hsd3b; LOC100911116", "gene_names_refseq": "Hsd1; Hsd3b5; Hsd3b; RATHSDI", "protein_names_uniprotkb": "NADPH-dependent 3-keto-steroid reductase Hsd3b5; 1.1.1.210; 1.1.1.270; 3 beta-HSD III; 3 beta-hydroxysteroid dehydrogenase type 3; 3 beta-hydroxysteroid dehydrogenase type III; Dihydrotestosterone 3-ketoreductase", "protein_names_refseq": "3 beta-HSD III; 3 beta-hydroxysteroid dehydrogenase 5; 3 beta-hydroxysteroid dehydrogenase type 3; 3 beta-hydroxysteroid dehydrogenase type 5-like; 3 beta-hydroxysteroid dehydrogenase type 5; 3 beta-hydroxysteroid dehydrogenase type III; 3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; NADPH-dependent 3-keto-steroid reductase Hsd3b5; dihydrotestosterone 3-ketoreductase; progesterone reductase; steroid delta-isomerase, 3 beta", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (rno:24470); (R-RNO-193048); (R-RNO-193993); (R-RNO-194002)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1537836;16020475;17428656;18511507;2249649;30884106", "class_list": "", "function": "ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells., [RefSeq, PubMed]; In ovariectomized-adrenalectomized rats, estrogen treatment increased 3beta-HSD mRNA in the hypothalamus., [RefSeq, PubMed]; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase., [UniProtKB, PubMed]; Significant decrease in the 3beta-HSD mRNA expression in traumatic brain injury site within the frontal cortex in both males and pseudopregnant females., [RefSeq, PubMed]; These steroidogenic enzymes within the Leydig cells, including steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage cytochrome P450 (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), were down-regulated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569C6", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0005496 steroid binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process;GO:0042448 progesterone metabolic process;GO:0050810 regulation of steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P27364-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0ZHH6-1", "uniprot_id": [ { "id": "ATLA3_RAT", "url": "https://www.uniprot.org/uniprot/Q0ZHH6", "type": "external" } ], "mass": 60586.0, "length": 541, "protein_name": "Atlastin-3", "gene_name": "Atl3", "organism": "Rat", "refseq_name": "atlastin-3 isoform 2", "refseq_ac": [ { "id": "NP_001037706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037706", "type": "external" } ], "gene_names_uniprotkb": "Atl3", "gene_names_refseq": "Atl3; RGD1309871", "protein_names_uniprotkb": "Atlastin-3; 3.6.5.-", "protein_names_refseq": "atlastin-3 isoform 2; atlastin-3", "tax_id": 10116, "disease": "hereditary sensory neuropathy type 1F (Disease Ontology:DOID:0070154); hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:309187)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14506257", "class_list": "", "function": "Atlastin-3 (ATL3) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (By similarity). Two atlastin-3 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0ZHH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22282-1", "uniprot_id": [ { "id": "22P1_RAT", "url": "https://www.uniprot.org/uniprot/P22282", "type": "external" } ], "mass": 21060.0, "length": 176, "protein_name": "Cystatin-related protein 1", "gene_name": "Andpro", "organism": "Rat", "refseq_name": "cystatin-related protein 1 precursor", "refseq_ac": [ { "id": "NP_036850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036850", "type": "external" } ], "gene_names_uniprotkb": "Andpro; Crp1", "gene_names_refseq": "Andpro; Crp1; RATANDPRO", "protein_names_uniprotkb": "Cystatin-related protein 1; Androgen-regulated 20 kDa protein; CRP-1; Prostatic 22 kDa glycoprotein P22K16/P22K20", "protein_names_refseq": "CRP-1; androgen regulated 20 kDa protein; cystatin-related protein 1 precursor; cystatin-related protein 1; prostatic 22 kDa glycoprotein P22K16/P22K20", "tax_id": 10116, "disease": "", "pathway": " (rno:25030)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "22090504;2280780;2477055;7679983;8262963;8462870", "class_list": "", "function": "This study demonistrated that CRP1 is required for the dendritic growth induced by Ca(2) influx or CaMKIV. Together, these data are the first to demonstrate a role for CRP1 in dendritic growth., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63674", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle", "go_biological_process": "GO:0071394 cellular response to testosterone stimulus;GO:0071549 cellular response to dexamethasone stimulus;GO:0030521 androgen receptor signaling pathway;GO:0045861 negative regulation of proteolysis;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P22282-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46953-1", "uniprot_id": [ { "id": "3HAO_RAT", "url": "https://www.uniprot.org/uniprot/P46953", "type": "external" } ], "mass": 32582.0, "length": 286, "protein_name": "3-hydroxyanthranilate 3,4-dioxygenase", "gene_name": "Haao", "organism": "Rat", "refseq_name": "3-hydroxyanthranilate 3,4-dioxygenase", "refseq_ac": [ { "id": "NP_064461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064461", "type": "external" } ], "gene_names_uniprotkb": "Haao; HAAO", "gene_names_refseq": "Haao", "protein_names_uniprotkb": "3-hydroxyanthranilate 3,4-dioxygenase; 1.13.11.6; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD", "protein_names_refseq": "3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAD", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:56823); (R-RNO-71240)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2940338;7514594;8541664", "class_list": "", "function": "Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70474;Q5RKK0;Q64556", "ec_number_list": [ { "id": "1.13.11.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.6", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity;GO:0008198 ferrous iron binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0010043 response to zinc ion;GO:0070050 neuron cellular homeostasis;GO:0046686 response to cadmium ion;GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46953-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32ZH6-1", "uniprot_id": [ { "id": "DFB15_RAT", "url": "https://www.uniprot.org/uniprot/Q32ZH6", "type": "external" } ], "mass": 9040.0, "length": 79, "protein_name": "Beta-defensin 15", "gene_name": "Defb15; Defb34", "organism": "Rat", "refseq_name": "beta-defensin 15 precursor", "refseq_ac": [ { "id": "NP_001032609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032609", "type": "external" } ], "gene_names_uniprotkb": "Defb15; Defb34; Defb15; Defb34; LOC120097516", "gene_names_refseq": "BD-15; Defb15", "protein_names_uniprotkb": "Beta-defensin 15; BD-15; Defensin, beta 15", "protein_names_refseq": "beta-defensin 15 precursor; beta-defensin 15-like; beta-defensin 15", "tax_id": 10116, "disease": "", "pathway": " (rno:641645)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16033865;20694738", "class_list": "", "function": "Has antibacterial activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that Defb15 plays a dual role in both sperm maturation and pathogen defense in rat epididymis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0001530 lipopolysaccharide binding;GO:0031727 CCR2 chemokine receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:1990742 microvesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32ZH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26772-1", "uniprot_id": [ { "id": "CH10_RAT", "url": "https://www.uniprot.org/uniprot/P26772", "type": "external" } ], "mass": 10902.0, "length": 102, "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "Hspe1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hspe1", "gene_names_refseq": "", "protein_names_uniprotkb": "10 kDa heat shock protein, mitochondrial; 10 kDa chaperonin; CPN10; Chaperonin 10; Hsp10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9013408)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1348860;7904573;8101099", "class_list": "", "function": "Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26772-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06646-1", "uniprot_id": [ { "id": "AT5G2_RAT", "url": "https://www.uniprot.org/uniprot/Q06646", "type": "external" } ], "mass": 14918.0, "length": 141, "protein_name": "ATP synthase F(0) complex subunit C2, mitochondrial", "gene_name": "Atp5mc2l1; Atp5mc2l2; Atp5mc2", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit C2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_598240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598240", "type": "external" } ], "gene_names_uniprotkb": "Atp5mc2l1; Atp5mc2l2; Atp5mc2; AABR07007730.1; AABR07068084.1; Atp5g2; Atp5mc2l1; LOC100361833", "gene_names_refseq": "Atp5g2; Atp5mc2", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 2; ATP synthase proteolipid P2; ATPase protein 9; ATPase subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C2, mitochondrial precursor; ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P2; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9); ATPase protein 9; ATPase subunit c", "tax_id": 10116, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143); urinary bladder cancer (Disease Ontology:DOID:11054); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (rno:100361833); (rno:171082); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "30530489;8448208", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VCW6", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0045471 response to ethanol;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis;GO:1905242 response to 3,3',5-triiodo-L-thyronine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q06646-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR5-1", "uniprot_id": [ { "id": "ACNT2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR5", "type": "external" } ], "mass": 46011.0, "length": 418, "protein_name": "Acyl-coenzyme A amino acid N-acyltransferase 2", "gene_name": "Acnat1; Acnat2", "organism": "Rat", "refseq_name": "acyl-coenzyme A amino acid N-acyltransferase 2", "refseq_ac": [ { "id": "NP_001014085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014085", "type": "external" } ], "gene_names_uniprotkb": "Acnat1; Acnat2; Acnat1", "gene_names_refseq": "Acnat2", "protein_names_uniprotkb": "Acyl-coenzyme A amino acid N-acyltransferase 2; 2.3.1.-", "protein_names_refseq": "acyl-coenzyme A amino acid N-acyltransferase 2; glycine N-choloyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:313220); (rno:681043)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016410 N-acyltransferase activity;GO:0016790 thiolester hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006637 acyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03348-1", "uniprot_id": [ { "id": "PTPRA_RAT", "url": "https://www.uniprot.org/uniprot/Q03348", "type": "external" } ], "mass": 90260.0, "length": 796, "protein_name": "Receptor-type tyrosine-protein phosphatase alpha", "gene_name": "Ptpra", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptpra; Lrp", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase alpha; 3.1.3.48; Protein-tyrosine phosphatase alpha; R-PTP-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (R-RNO-375165); (R-RNO-5673001)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1417854;22673903;38843836", "class_list": "", "function": "Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity)., [UniProtKB, UniProtKB]; Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0016020 membrane;GO:0043235 receptor complex;GO:0097060 synaptic membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03348-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16259-1", "uniprot_id": [ { "id": "CAN3_RAT", "url": "https://www.uniprot.org/uniprot/P16259", "type": "external" } ], "mass": 94127.0, "length": 821, "protein_name": "Calpain-3", "gene_name": "Capn3", "organism": "Rat", "refseq_name": "calpain-3", "refseq_ac": [ { "id": "NP_058813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058813", "type": "external" } ], "gene_names_uniprotkb": "Capn3", "gene_names_refseq": "Capn3; Lp82; Lp84; Lp85; p94", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54; CANP 3; Calcium-activated neutral proteinase 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3", "protein_names_refseq": "CANP 3; calcium-activated neutral proteinase 3; calpain L3; calpain p94; calpain-3; muscle-specific calcium-activated neutral protease 3", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy (Disease Ontology:DOID:0110273); autosomal recessive limb-girdle muscular dystrophy type 2A (Disease Ontology:DOID:0110275); hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29155); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2555341;26569227;29783071;34638951", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-399'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB]; Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening. Publication Status: Online-Only, [RefSeq, PubMed]; MEF2A is a transcriptional regulator for Capn3 gene expression., [RefSeq, PubMed]; The expression pattern of the active CAPN3 protein is linked to muscle atrophy and regeneration following denervation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1990091 sodium-dependent self proteolysis;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16259-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60905-1", "uniprot_id": [ { "id": "DNJC5_RAT", "url": "https://www.uniprot.org/uniprot/P60905", "type": "external" } ], "mass": 22101.0, "length": 198, "protein_name": "DnaJ homolog subfamily C member 5", "gene_name": "Dnajc5", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 5", "refseq_ac": [ { "id": "NP_077075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077075", "type": "external" } ], "gene_names_uniprotkb": "Dnajc5", "gene_names_refseq": "Csp; Dnajc5", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 5; CSP; Cysteine string protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 5; cysteine string protein; dnaJ homolog subfamily C member 5", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 4 (Disease Ontology:DOID:0110720); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (rno:79130); (R-RNO-6798695); (R-RNO-888590)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11257428;11604405;11931641;22666389;22673903;23942053;24956274;25253725;25800794;7535880;8606785", "class_list": "", "function": "A biochemical link between Hsp40 expression and Abeta(42) proteostasis that is cell specific, [RefSeq, PubMed]; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Both the J-domain and the linker domain of CSP1 are necessary to function in an important role in acinar cell exocytosis, [RefSeq, PubMed]; CSPalpha may modulate fusion pore dynamics in a phosphorylation-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation-dependent interaction with synaptotagmin I, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P54101", "ec_number_list": [], "go_molecular_function": "GO:0043008 ATP-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0043524 negative regulation of neuron apoptotic process;GO:0006457 protein folding;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P60905-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7B1-1", "uniprot_id": [ { "id": "CF20D_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7B1", "type": "external" } ], "mass": 71915.0, "length": 658, "protein_name": "Protein CFAP20DC", "gene_name": "Cfap20dc", "organism": "Rat", "refseq_name": "protein CFAP20DC isoform 2", "refseq_ac": [ { "id": "NP_001014159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014159", "type": "external" } ], "gene_names_uniprotkb": "Cfap20dc; LOC361016", "gene_names_refseq": "Cfap20dc", "protein_names_uniprotkb": "Protein CFAP20DC", "protein_names_refseq": "protein CFAP20DC isoform 2; protein CFAP20DC; uncharacterized protein C3orf67 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361016)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EGZ1-1", "uniprot_id": [ { "id": "ACE2_RAT", "url": "https://www.uniprot.org/uniprot/Q5EGZ1", "type": "external" } ], "mass": 92491.0, "length": 805, "protein_name": "Angiotensin-converting enzyme 2", "gene_name": "Ace2", "organism": "Rat", "refseq_name": "angiotensin-converting enzyme 2 precursor", "refseq_ac": [ { "id": "NP_001012006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012006", "type": "external" } ], "gene_names_uniprotkb": "Ace2", "gene_names_refseq": "Ace2", "protein_names_uniprotkb": "Angiotensin-converting enzyme 2; 3.4.17.-; 3.4.17.23; ACE-related carboxypeptidase", "protein_names_refseq": "ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2 precursor; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); primary biliary cholangitis (Disease Ontology:DOID:12236); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cerebral malaria (Disease Ontology:DOID:14069); glaucoma (Disease Ontology:DOID:1686); severe acute respiratory syndrome (Disease Ontology:DOID:2945); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:302668); (R-RNO-2022377)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12075344;15231706;15452268;15671045;15949646;37539550;37716548;38183511;38892464;39013481", "class_list": "", "function": "ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway., [RefSeq, PubMed]; Activation of angiotensin converting enzyme 2 promotes hippocampal neurogenesis via activation of Wnt/beta-catenin signaling in hypertension., [RefSeq, PubMed]; Angiotensin-converting enzyme 2 (Ace2)is an essential regulator of heart function., [RefSeq, PubMed]; Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in intestine, regulating trafficking, expression on the cell surface, and its catalytic activity., [UniProtKB, UniProtKB]; Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats., [RefSeq, PubMed]; SARS-CoV-2 Spike Protein Enhances Carboxypeptidase Activity of Angiotensin-Converting Enzyme 2. Publication Status: Online-Only, [RefSeq, PubMed]; Sirt1 activation prevents high glucose-induced angiotensin converting enzyme 2 downregulation in renal tubular cells by regulating the TIMP3/ADAM17 pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.23", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002003 angiotensin maturation;GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin;GO:0060135 maternal process involved in female pregnancy;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q5EGZ1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17475-1", "uniprot_id": [ { "id": "A1AT_RAT", "url": "https://www.uniprot.org/uniprot/P17475", "type": "external" } ], "mass": 46136.0, "length": 411, "protein_name": "Alpha-1-antiproteinase", "gene_name": "Serpina1fl1; Serpina1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serpina1fl1; Serpina1; LOC690319; Serpina1", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1-antiproteinase; Alpha-1-antitrypsin; Alpha-1-proteinase inhibitor; Serpin A1", "protein_names_refseq": "", "tax_id": 10116, "disease": "chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); liver disease (Disease Ontology:DOID:409); primary hyperaldosteronism (Disease Ontology:DOID:446); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24648); (rno:690319); (R-RNO-114608); (R-RNO-204005); (R-RNO-381426); (R-RNO-5694530); (R-RNO-6798695); (R-RNO-8957275)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21454685;2229024;2302382", "class_list": "", "function": "Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYZ5", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010288 response to lead ion;GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0006953 acute-phase response;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17475-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16303-1", "uniprot_id": [ { "id": "EST1D_RAT", "url": "https://www.uniprot.org/uniprot/P16303", "type": "external" } ], "mass": 62147.0, "length": 565, "protein_name": "Carboxylesterase 1D", "gene_name": "Ces1d", "organism": "Rat", "refseq_name": "carboxylesterase 1D precursor", "refseq_ac": [ { "id": "NP_579829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579829", "type": "external" } ], "gene_names_uniprotkb": "Ces1d; Ces1f; Ces3", "gene_names_refseq": "Ces1d; Ces3", "protein_names_uniprotkb": "Carboxylesterase 1D; 3.1.1.1; 3.1.1.67; Carboxyesterase ES-10; Carboxylesterase 3; ES-HVEL; FAEE synthase; Fatty acid ethyl ester synthase; Liver carboxylesterase 10; pI 6.1 esterase", "protein_names_refseq": "ES-HVEL; FAEE synthase; carboxyesterase ES-10; carboxylesterase 1D precursor; carboxylesterase 3; fatty acid ethyl ester synthase; liver carboxylesterase 10; pI 6.1 esterase", "tax_id": 10116, "disease": "", "pathway": " (rno:113902); (R-RNO-2022377); (R-RNO-211945); (R-RNO-5578768); (R-RNO-9749641)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "11429416;12230550;1429692;1606962;2386485;8541339;8597091", "class_list": "", "function": "Major lipase in white adipose tissue (By similarity). Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters (PubMed:1429692). Hydrolyzes retinyl esters (PubMed:12230550)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q64574;Q6P785;Q91YG2;Q9QUX7;Q9R135", "ec_number_list": [ { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.88", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.28", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.67", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0030339 fatty-acyl-ethyl-ester synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0070417 cellular response to cold;GO:0060086 circadian temperature homeostasis;GO:0001523 retinoid metabolic process;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16303-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C588-1", "uniprot_id": [ { "id": "CNNM4_RAT", "url": "https://www.uniprot.org/uniprot/P0C588", "type": "external" } ], "mass": 86692.0, "length": 772, "protein_name": "Metal transporter CNNM4", "gene_name": "Cnnm4", "organism": "Rat", "refseq_name": "metal transporter CNNM4 precursor", "refseq_ac": [ { "id": "NP_001257979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257979", "type": "external" } ], "gene_names_uniprotkb": "Cnnm4; Acdp4", "gene_names_refseq": "Cnnm4", "protein_names_uniprotkb": "Metal transporter CNNM4; Ancient conserved domain-containing protein 4; Cyclin-M4", "protein_names_refseq": "ancient conserved domain-containing protein 4; cyclin-M4; metal transporter CNNM4 precursor; metal transporter CNNM4", "tax_id": 10116, "disease": "Jalili syndrome (Disease Ontology:DOID:0111404)", "pathway": " (rno:363216)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15840172;19200525;22673903", "class_list": "", "function": "Metal transporter., [UniProtKB, UniProtKB]; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015081 sodium ion transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0007601 visual perception;GO:0070166 enamel mineralization;GO:0010960 magnesium ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVC2-1", "uniprot_id": [ { "id": "ARHG2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVC2", "type": "external" } ], "mass": 111909.0, "length": 985, "protein_name": "Rho guanine nucleotide exchange factor 2", "gene_name": "Arhgef2", "organism": "Rat", "refseq_name": "rho guanine nucleotide exchange factor 2 isoform 1", "refseq_ac": [ { "id": "NP_001012079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012079", "type": "external" } ], "gene_names_uniprotkb": "Arhgef2", "gene_names_refseq": "Arhgef2", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 2; GEF-H1; Guanine nucleotide exchange factor H1", "protein_names_refseq": "GEF-H1; guanine nucleotide exchange factor H1; rho guanine nucleotide exchange factor 2 isoform 1; rho guanine nucleotide exchange factor 2; rho/rac guanine nucleotide exchange factor (GEF) 2", "tax_id": 10116, "disease": "neurodevelopmental disorder with midbrain and hindbrain malformations (Disease Ontology:DOID:0080312)", "pathway": " (rno:310635); (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "18394899;22673903;24356971;25447939;26866809;27003208;38843836", "class_list": "", "function": "Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability. Involved in neuronal progenitor cell division and differentiation. Involved in the migration of precerebellar neurons., [UniProtKB, UniProtKB, UniProtKB]; Complement-induced ERK-dependent GEF-H1 activation as the upstream mechanism of RhoA stimulation, and this pathway has a protective role against cell death., [RefSeq, PubMed]; Regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms Publication Status: Online-Only, [RefSeq, PubMed]; Results indicated that Tau produced strong plasma membrane blebbing and F-Actin cytoskeleton remodeling by indirect activation of the GEF-H1-RhoA-ROCK pathway. All of these actions were initiated by abnormal, induced microtubule bundling and cytoplasmic release of GEF-H1., [RefSeq, PubMed]; Upregulation of GEF-H1 activity may contribute to excitotoxicity, whereas the late upregulation of GEF-H1 protein may promote neuroplasticity after brain ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0045087 innate immune response;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5FVC2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85970-1", "uniprot_id": [ { "id": "ARPC2_RAT", "url": "https://www.uniprot.org/uniprot/P85970", "type": "external" } ], "mass": 34391.0, "length": 300, "protein_name": "Actin-related protein 2/3 complex subunit 2", "gene_name": "Arpc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arpc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); silicosis (Disease Ontology:DOID:10325); melanoma (Disease Ontology:DOID:1909); invasive ductal carcinoma (Disease Ontology:DOID:3008); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (rno:301511); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "18683930;19343716", "class_list": "", "function": "Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0061826 podosome ring;GO:0061834 actin filament branch point;GO:0061835 ventral surface of cell;GO:0005634 nucleus", "go_biological_process": "GO:0072752 cellular response to rapamycin;GO:0034021 response to silicon dioxide;GO:2000814 positive regulation of barbed-end actin filament capping;GO:0032956 regulation of actin cytoskeleton organization;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P85970-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18757-1", "uniprot_id": [ { "id": "CGL_RAT", "url": "https://www.uniprot.org/uniprot/P18757", "type": "external" } ], "mass": 43605.0, "length": 398, "protein_name": "Cystathionine gamma-lyase", "gene_name": "Cth", "organism": "Rat", "refseq_name": "cystathionine gamma-lyase", "refseq_ac": [ { "id": "NP_058770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058770", "type": "external" } ], "gene_names_uniprotkb": "Cth", "gene_names_refseq": "CGL; CSE; Cth", "protein_names_uniprotkb": "Cystathionine gamma-lyase; 4.4.1.1; 4.4.1.2; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; PRB-RA; Probasin-related antigen", "protein_names_refseq": "CTL target antigen; PRB-RA; cystathionase (cystathionine gamma-lyase); cystathionine gamma-lyase; cysteine desulfhydrase; cysteine-protein sulfhydrase; gamma-cystathionase; homocysteine desulfhydrase; probasin-related antigen", "tax_id": 10116, "disease": "cystathioninuria (Disease Ontology:DOID:0090142); cataract (Disease Ontology:DOID:83); amino acid metabolic disorder (Disease Ontology:DOID:9252); homocystinuria (Disease Ontology:DOID:9263)", "pathway": " (rno:24962); (R-RNO-1614558); (R-RNO-1614603)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "13525371;2201285;22673903;29880385;32900241;33123916;36197015;38613810;6456763;8288556", "class_list": "", "function": "Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine gamma-lyase expression in a rat model of intracerebral hemorrhage., [RefSeq, PubMed]; Activity of Gas Transmitters in Vessels of the Anterior Abdominal Wall after Implantation of a Polypropylene Mesh., [RefSeq, PubMed]; CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation., [RefSeq, PubMed]; Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (Probable) (PubMed:13525371). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (PubMed:13525371). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose., [RefSeq, PubMed]; Indings show that brief and repeated ischemic postconditioning increased the expression of CSE after ischemia/reperfusion in diabetes mellitus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.1", "type": "external" }, { "id": "4.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004123 cystathionine gamma-lyase activity;GO:0044540 L-cystine L-cysteine-lyase (deaminating)", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051289 protein homotetramerization;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18757-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02356-1", "uniprot_id": [ { "id": "AMPD2_RAT", "url": "https://www.uniprot.org/uniprot/Q02356", "type": "external" } ], "mass": 94787.0, "length": 824, "protein_name": "AMP deaminase 2", "gene_name": "Ampd2", "organism": "Rat", "refseq_name": "AMP deaminase 2", "refseq_ac": [ { "id": "NP_001095151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095151", "type": "external" } ], "gene_names_uniprotkb": "Ampd2", "gene_names_refseq": "Ampd2; Ampd", "protein_names_uniprotkb": "AMP deaminase 2; 3.5.4.6; AMP deaminase isoform L", "protein_names_refseq": "AMP deaminase 2; adenosine monophosphate deaminase 2 (isoform L)", "tax_id": 10116, "disease": "pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); pontocerebellar hypoplasia type 9 (Disease Ontology:DOID:0060278); hereditary spastic paraplegia 63 (Disease Ontology:DOID:0110814)", "pathway": " (rno:362015); (R-RNO-74217)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;2365682", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2GUT6", "ec_number_list": [ { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0009117 nucleotide metabolic process;GO:0097009 energy homeostasis;GO:0042632 cholesterol homeostasis;GO:0006188 IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02356-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLY6-1", "uniprot_id": [ { "id": "DCR1B_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLY6", "type": "external" } ], "mass": 60924.0, "length": 541, "protein_name": "5' exonuclease Apollo", "gene_name": "Dclre1b", "organism": "Rat", "refseq_name": "5' exonuclease Apollo", "refseq_ac": [ { "id": "NP_001020858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020858", "type": "external" } ], "gene_names_uniprotkb": "Dclre1b; Snm1b", "gene_names_refseq": "Dclre1b", "protein_names_uniprotkb": "5' exonuclease Apollo; 3.1.-.-; 3.5.2.6; Beta-lactamase MBLAC2; DNA cross-link repair 1B protein; SNM1 homolog B", "protein_names_refseq": "5' exonuclease Apollo; DNA cross-link repair 1B protein; SNM1 homolog B; beta-lactamase MBLAC2", "tax_id": 10116, "disease": "dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (rno:310745); (R-RNO-6783310)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint (By similarity). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0016604 nuclear body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0031848 protection from non-homologous end joining at telomere;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLN7-1", "uniprot_id": [ { "id": "ARFG3_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLN7", "type": "external" } ], "mass": 57671.0, "length": 525, "protein_name": "ADP-ribosylation factor GTPase-activating protein 3", "gene_name": "Arfgap3", "organism": "Rat", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 3", "refseq_ac": [ { "id": "NP_001037738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037738", "type": "external" } ], "gene_names_uniprotkb": "Arfgap3", "gene_names_refseq": "Arfgap3", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3", "protein_names_refseq": "ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3", "tax_id": 10116, "disease": "", "pathway": " (rno:503165); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-9013408)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048786 presynaptic active zone;GO:0098684 photoreceptor ribbon synapse", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0009306 protein secretion;GO:0140238 presynaptic endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62738-1", "uniprot_id": [ { "id": "ACTA_RAT", "url": "https://www.uniprot.org/uniprot/P62738", "type": "external" } ], "mass": 42009.0, "length": 377, "protein_name": "Actin, aortic smooth muscle", "gene_name": "Acta2; Actc1", "organism": "Rat", "refseq_name": "actin, aortic smooth muscle", "refseq_ac": [ { "id": "NP_112266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112266", "type": "external" } ], "gene_names_uniprotkb": "Acta2; Actc1; Acta1; Actc1; Actg2; Actsa; Actvs", "gene_names_refseq": "Acta2", "protein_names_uniprotkb": "Actin, aortic smooth muscle; 3.6.4.-; Alpha-actin-2", "protein_names_refseq": "actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; alpha-actin-2; smooth muscle alpha-actin", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); intestinal atresia (Disease Ontology:DOID:10486); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); lymphedema (Disease Ontology:DOID:4977)", "pathway": " (rno:81633); (R-RNO-445355); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9958825)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "18683930;3234770;3375082;34052675;6546444", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P03996;P04108;P70476", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0031514 motile cilium", "go_biological_process": "GO:2000491 positive regulation of hepatic stellate cell activation;GO:0006936 muscle contraction;GO:0010628 positive regulation of gene expression;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62738-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLF8-1", "uniprot_id": [ { "id": "ARPC5_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLF8", "type": "external" } ], "mass": 16320.0, "length": 151, "protein_name": "Actin-related protein 2/3 complex subunit 5", "gene_name": "Arpc5", "organism": "Rat", "refseq_name": "actin-related protein 2/3 complex subunit 5", "refseq_ac": [ { "id": "NP_001020888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020888", "type": "external" } ], "gene_names_uniprotkb": "Arpc5", "gene_names_refseq": "Arpc5", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 5; Arp2/3 complex 16 kDa subunit; p16-ARC", "protein_names_refseq": "actin-related protein 2/3 complex subunit 5; arp2/3 complex 16 kDa subunit; p16-ARC", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); immunodeficiency 113 (Disease Ontology:DOID:0051056); candidiasis (Disease Ontology:DOID:1508); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:360854); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213); (R-RNO-6798695); (R-RNO-8856828)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "23459330", "class_list": "", "function": "CRMP2B and ARPC5 may participate in CNS injury mediated by hypothyroidism by inducing neurite outgrowth inhibition and cytoskeletal protein disorganization., [RefSeq, PubMed]; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005768 endosome;GO:0014069 postsynaptic density;GO:0030027 lamellipodium", "go_biological_process": "GO:0016477 cell migration;GO:0014909 smooth muscle cell migration;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0051639 actin filament network formation;GO:0021769 orbitofrontal cortex development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97888-1", "uniprot_id": [ { "id": "2ABG_RAT", "url": "https://www.uniprot.org/uniprot/P97888", "type": "external" } ], "mass": 51474.0, "length": 447, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform", "gene_name": "Ppp2r2c", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1", "refseq_ac": [ { "id": "NP_476457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476457", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r2c", "gene_names_refseq": "Ppp2r2c; Pr52", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform BRgamma; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-gamma; PP2A subunit B isoform gamma", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1", "tax_id": 10116, "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)", "pathway": " (rno:117256)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12191994;12644453;34635097;7607250", "class_list": "", "function": "PP2A has a role in glucose-regulated EF-2 phosphorylation and protein translation in rat cells, [RefSeq, PubMed]; PP2A/Bgamma is a positive regulator of MAP kinase signaling in neurons., [RefSeq, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment., [UniProtKB]; Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97888-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23363-1", "uniprot_id": [ { "id": "BDNF_RAT", "url": "https://www.uniprot.org/uniprot/P23363", "type": "external" } ], "mass": 28109.0, "length": 249, "protein_name": "Neurotrophic factor BDNF precursor form", "gene_name": "Bdnf", "organism": "Rat", "refseq_name": "neurotrophic factor BDNF precursor form isoform 1", "refseq_ac": [ { "id": "NP_001257559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257559", "type": "external" } ], "gene_names_uniprotkb": "Bdnf", "gene_names_refseq": "Bdnf", "protein_names_uniprotkb": "Neurotrophic factor BDNF precursor form; Brain-derived neurotrophic factor; proBDNF", "protein_names_refseq": "brain derived neurothrophic factor; neurotrophic factor BDNF precursor form isoform 1; neurotrophic factor BDNF precursor form; proBDNF", "tax_id": 10116, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); porencephaly (Disease Ontology:DOID:0060263); congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); brain small vessel disease 1 (Disease Ontology:DOID:0090125); retinal arterial tortuosity (Disease Ontology:DOID:0111547); keratoconus (Disease Ontology:DOID:10126); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sciatic neuropathy (Disease Ontology:DOID:11446); trigeminal neuralgia (Disease Ontology:DOID:12098); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); uterine fibroid (Disease Ontology:DOID:13223); color blindness (Disease Ontology:DOID:13399); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); premature ejaculation (Disease Ontology:DOID:13709); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); major depressive disorder (Disease Ontology:DOID:1470); urticaria (Disease Ontology:DOID:1555); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); mood disorder (Disease Ontology:DOID:3324); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); myopathy (Disease Ontology:DOID:423); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); intestinal disease (Disease Ontology:DOID:5295); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); acute stress disorder (Disease Ontology:DOID:6088); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); retinal degeneration (Disease Ontology:DOID:8466); collagen disease (Disease Ontology:DOID:854); vascular dementia (Disease Ontology:DOID:8725); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypertensive encephalopathy (Disease Ontology:DOID:9427); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); irritable bowel syndrome (Disease Ontology:DOID:9778); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24225); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9026527); (R-RNO-9028731); (R-RNO-9032759)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "1446835;16376315;17149751;1889806;1966766;2025430;38648864;38796067;38838971;38892438;39125587;8461137", "class_list": "", "function": "An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons., [RefSeq, PubMed]; Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus., [RefSeq, PubMed]; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular Adaptations of BDNF/NT-4 Neurotrophic and Muscarinic Pathways in Ageing Neuromuscular Synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Unlocking the epigenome: Stress and exercise induced Bdnf regulation in the prefrontal cortex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 77, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53YL8", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005169 neurotrophin TRKB receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046668 regulation of retinal cell programmed cell death;GO:0061193 taste bud development;GO:1990089 response to nerve growth factor;GO:0048172 regulation of short-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P23363-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34080-1", "uniprot_id": [ { "id": "AQP2_RAT", "url": "https://www.uniprot.org/uniprot/P34080", "type": "external" } ], "mass": 28931.0, "length": 271, "protein_name": "Aquaporin-2", "gene_name": "Aqp2", "organism": "Rat", "refseq_name": "aquaporin-2", "refseq_ac": [ { "id": "NP_037041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037041", "type": "external" } ], "gene_names_uniprotkb": "Aqp2", "gene_names_refseq": "AQP-2; Aqp2; aquaporin-2", "protein_names_uniprotkb": "Aquaporin-2; ADH water channel; AQP-2; AQP-CD; Aquaporin-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct", "protein_names_refseq": "ADH water channel; AQP-CD; WCH-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct", "tax_id": 10116, "disease": "nephrogenic diabetes insipidus type 2 (Disease Ontology:DOID:0081061); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); diabetic ketoacidosis (Disease Ontology:DOID:1837); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (rno:25386); (R-RNO-432040); (R-RNO-432047)", "pathway_count": 3, "publication_count": 50, "publication_id_list": "10392550;10644653;10710543;10710544;10919858;11249863;12388409;14605277;15010357;15585668;15625084;15644488;16174867;16641100;16985212;18029369;18596208;19193739;19794145;21220937;21511701;21525134;22028046;22621967;22673903;24305472;25651562;25658446;26074997;26674602;27405971;27465993;27488997;27760768;28139295;29357442;30941057;31447686;32295252;33255239;33633156;35054947;35068345;35386692;35918145;37114282;7505572;7508187;8429910;8621414", "class_list": "", "function": "'Aquaporin-omics': mechanisms of aquaporin-2 loss in polyuric disorders., [RefSeq, PubMed]; AQP2 Promotes Astrocyte Activation by Modulating the TLR4/NFkappaB-p65 Pathway Following Intracerebral Hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rats., [RefSeq, PubMed]; Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy., [RefSeq, PubMed]; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:7508187, PubMed:8429910). Plays an essential role in renal water homeostasis (By similarity). Could also be permeable to glycerol (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1A5L4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030165 PDZ domain binding;GO:0005372 water transmembrane transporter activity;GO:0015168 glycerol transmembrane transporter activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0007015 actin filament organization;GO:0032496 response to lipopolysaccharide;GO:0042594 response to starvation;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P34080-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41739-1", "uniprot_id": [ { "id": "ARNT_RAT", "url": "https://www.uniprot.org/uniprot/P41739", "type": "external" } ], "mass": 88221.0, "length": 800, "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "Arnt", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arnt", "gene_names_refseq": "", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Dioxin receptor, nuclear translocator; HIF-1-beta; HIF1-beta; Hypoxia-inducible factor 1-beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "achromatopsia 3 (Disease Ontology:DOID:0110008); hypertension (Disease Ontology:DOID:10763); color blindness (Disease Ontology:DOID:13399); renal cell carcinoma (Disease Ontology:DOID:4450); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25242); (R-RNO-1234158); (R-RNO-211945); (R-RNO-211976); (R-RNO-211981); (R-RNO-8937144); (R-RNO-9768919)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "8065918", "class_list": "", "function": "Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target gene promoters. Also heterodimerizes with hypoxia-inducible factor alpha subunits (HIF1A, EPAS1, NPAS1 or NPAS3) to form hypoxia-inducible transcription factors that bind hypoxia response elements (HREs) and activate genes involved in cellular and systemic responses to hypoxia, including angiogenesis, erythropoiesis, and metabolic adaptation (By similarity). Plays a central role in environmental sensing and developmental and physiological regulation of gene expression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0017162 aryl hydrocarbon receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P41739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1WIM3-1", "uniprot_id": [ { "id": "CADM3_RAT", "url": "https://www.uniprot.org/uniprot/Q1WIM3", "type": "external" } ], "mass": 42906.0, "length": 396, "protein_name": "Cell adhesion molecule 3", "gene_name": "Cadm3", "organism": "Rat", "refseq_name": "cell adhesion molecule 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001040568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040568", "type": "external" } ], "gene_names_uniprotkb": "Cadm3; Igsf4b; Necl1", "gene_names_refseq": "Cadm3; Igsf4b; Necl-1", "protein_names_uniprotkb": "Cell adhesion molecule 3; IgSF4B; Immunoglobulin superfamily member 4B; NECL-1; Nectin-like protein 1", "protein_names_refseq": "cell adhesion molecule 3 isoform 2 precursor; immunoglobulin superfamily, member 4B; nectin-like protein 1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (rno:360882); (R-RNO-418990); (R-RNO-420597)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16773244;17724124;18686604;22673903", "class_list": "", "function": "Involved in cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Necl1 plays an important role in neuronal synapse formation., [RefSeq, PubMed]; Nectin-like molecule 1 (Necl-1) is unique for its exclusive expression in the brain where it is localized at the contact sites among axon terminals and glia cell processes, cooperatively forming synapses., [RefSeq, PubMed]; These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005911 cell-cell junction;GO:0042734 presynaptic membrane;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0008104 intracellular protein localization;GO:0099560 synaptic membrane adhesion;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1WIM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G059-1", "uniprot_id": [ { "id": "CDA7L_RAT", "url": "https://www.uniprot.org/uniprot/Q4G059", "type": "external" } ], "mass": 49973.0, "length": 438, "protein_name": "Cell division cycle-associated 7-like protein", "gene_name": "Cdca7l", "organism": "Rat", "refseq_name": "cell division cycle-associated 7-like protein", "refseq_ac": [ { "id": "NP_001030125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030125", "type": "external" } ], "gene_names_uniprotkb": "Cdca7l", "gene_names_refseq": "Cdca7l", "protein_names_uniprotkb": "Cell division cycle-associated 7-like protein", "protein_names_refseq": "cell division cycle-associated 7-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:619566)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G059-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15393-1", "uniprot_id": [ { "id": "C11B1_RAT", "url": "https://www.uniprot.org/uniprot/P15393", "type": "external" } ], "mass": 57459.0, "length": 499, "protein_name": "Cytochrome P450 11B1, mitochondrial", "gene_name": "Cyp11b1; Cyp11b2l1; Cyp11b2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp11b1; Cyp11b2l1; Cyp11b2; Cyp11b-1; Cyp11b1; Cyp11b2l1; Cyp11b3; LOC120093683", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 11B1, mitochondrial; 1.14.15.4; CYPXIB1; Cytochrome P450(11 beta)-DS; Cytochrome P450C11; Steroid 11-beta-hydroxylase, CYP11B1", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); glucocorticoid-remediable aldosteronism (Disease Ontology:DOID:14080); colon cancer (Disease Ontology:DOID:219); invasive ductal carcinoma (Disease Ontology:DOID:3008); brain infarction (Disease Ontology:DOID:3454); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (rno:500892); (R-RNO-194002); (R-RNO-211976)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1562515;1765101;2551730;2738055;7626522;8468320;8473350;8473352", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:1562515, PubMed:1765101, PubMed:2738055). Catalyzes a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones (By similarity). Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19 (PubMed:1562515, PubMed:1765101). Catalyzes the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone (PubMed:1562515, PubMed:1765101, PubMed:2738055). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Due to its lack of 18-oxidation activity, it is incapable of generating aldosterone. Besides its role in the biosynthesis of mineralocorticoids and glucocorticoids, it can also participate in the androgen metabolic pathway, converting androst-4-ene-3,17-dione to 11beta-hydroxyandrost-4-ene-3,17-dione, and testosterone (17beta-hydroxy-4-androsten-3-one) to 11beta,17beta-dihydroxyandrost-4-ene-3-one (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64655", "ec_number_list": [ { "id": "1.14.15.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005496 steroid binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P15393-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97694-1", "uniprot_id": [ { "id": "CYH1_RAT", "url": "https://www.uniprot.org/uniprot/P97694", "type": "external" } ], "mass": 46274.0, "length": 398, "protein_name": "Cytohesin-1", "gene_name": "Cyth1", "organism": "Rat", "refseq_name": "cytohesin-1", "refseq_ac": [ { "id": "NP_446362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446362", "type": "external" } ], "gene_names_uniprotkb": "Cyth1; Pscd1; Sec7a", "gene_names_refseq": "Cyth1; Pscd1; Sec7", "protein_names_uniprotkb": "Cytohesin-1; PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog A; rSec7-1", "protein_names_refseq": "PH, SEC7 and coiled-coil domain-containing protein 1; SEC7 homolog A; cytohesin-1; pleckstrin homology, Sec7 and coiled-coil domains 1; pleckstrin homology, Sec7 and coiled/coil domains 1(cytohesin 1); rSec7-1", "tax_id": 10116, "disease": "", "pathway": " (rno:116691); (R-RNO-6811438)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11834294;14499594;9352219;9927699", "class_list": "", "function": "Data suggest that oligomerization of inositol phosphate/phosphatidylinositol binding proteins such as cytoadhesin 1 and centaurin alpha 1 can modulate their function in a tissue-dependent manner., [RefSeq, PubMed]; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098888 extrinsic component of presynaptic membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:0016192 vesicle-mediated transport;GO:0090162 establishment of epithelial cell polarity;GO:0032012 regulation of ARF protein signal transduction;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97694-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MQ06-1", "uniprot_id": [ { "id": "ATG5_RAT", "url": "https://www.uniprot.org/uniprot/Q3MQ06", "type": "external" } ], "mass": 32398.0, "length": 275, "protein_name": "Autophagy protein 5", "gene_name": "Atg5", "organism": "Rat", "refseq_name": "autophagy protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001385949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385949", "type": "external" } ], "gene_names_uniprotkb": "Atg5", "gene_names_refseq": "Atg5", "protein_names_uniprotkb": "Autophagy protein 5", "protein_names_refseq": "ATG5 autophagy related 5 homolog; autophagy protein 5 isoform 3; autophagy protein 5", "tax_id": 10116, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 25 (Disease Ontology:DOID:0080259); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); ischemia (Disease Ontology:DOID:326)", "pathway": " (R-RNO-1632852); (R-RNO-5205685); (R-RNO-8934903)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "33831322;34734681;34958937;35927903", "class_list": "", "function": "Bortezomib alleviates antibody-mediated rejection in kidney transplantation by facilitating Atg5 expression., [RefSeq, PubMed]; Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5., [RefSeq, PubMed]; Involved in autophagic vesicle formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Involvement of autophagy in the maintenance of rat intervertebral disc homeostasis: an in-vitro and in-vivo RNA interference study of Atg5., [RefSeq, PubMed]; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-30a-5p Promotes Vein Graft Restenosis by Inhibiting Cell Autophagy through Targeting ATG5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019776 Atg8-family ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990234 transferase complex;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1904973 positive regulation of viral translation;GO:0061684 chaperone-mediated autophagy;GO:0002718 regulation of cytokine production involved in immune response;GO:0000045 autophagosome assembly;GO:0039689 negative stranded viral RNA replication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3MQ06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48284-1", "uniprot_id": [ { "id": "CAH4_RAT", "url": "https://www.uniprot.org/uniprot/P48284", "type": "external" } ], "mass": 35076.0, "length": 309, "protein_name": "Carbonic anhydrase 4", "gene_name": "Ca4", "organism": "Rat", "refseq_name": "carbonic anhydrase 4 precursor", "refseq_ac": [ { "id": "NP_062047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062047", "type": "external" } ], "gene_names_uniprotkb": "Ca4; Car4", "gene_names_refseq": "Ca4; Car4", "protein_names_uniprotkb": "Carbonic anhydrase 4; 4.2.1.1; CA-IV; Carbonate dehydratase IV; Carbonic anhydrase IV", "protein_names_refseq": "CA-IV; carbonate dehydratase IV; carbonic anhydrase 4 precursor; carbonic anhydrase IV", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:29242); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-1475029)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "16144999;1737787;24090084;24989426;8279579", "class_list": "", "function": "Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Vascular mineral loss induced by blockade of endothelin receptors seems dependent on activation of membrane-bound carbonic anhydrase IV. Mineral loss may proceed via local changes in pH similar to that seen in bone resorption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR97", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048545 response to steroid hormone;GO:0009410 response to xenobiotic stimulus;GO:0015701 bicarbonate transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48284-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4AEG6-1", "uniprot_id": [ { "id": "BMP10_RAT", "url": "https://www.uniprot.org/uniprot/Q4AEG6", "type": "external" } ], "mass": 47767.0, "length": 421, "protein_name": "Bone morphogenetic protein 10", "gene_name": "Bmp10", "organism": "Rat", "refseq_name": "bone morphogenetic protein 10 precursor", "refseq_ac": [ { "id": "NP_001026994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026994", "type": "external" } ], "gene_names_uniprotkb": "Bmp10", "gene_names_refseq": "Bmp10", "protein_names_uniprotkb": "Bone morphogenetic protein 10; BMP-10", "protein_names_refseq": "BMP-10; bone morphogenetic protein 10 precursor", "tax_id": 10116, "disease": "hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:500245); (R-RNO-201451); (R-RNO-2129379)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15978772;22797972;24906204;31243186", "class_list": "", "function": "Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present data suggested that BMP-10 may be implicated in CNS pathophysiology after traumatic brain injury, [RefSeq, PubMed]; These data indicated that BMP10 stimulated cardiomyocyte proliferation and repaired cardiac function after heart injury., [RefSeq, PubMed]; W143*-NRG1and V470I-BMP10 variants are associated with left ventricular non-compaction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031433 telethonin binding;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0030018 Z disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0001822 kidney development;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4AEG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32214-1", "uniprot_id": [ { "id": "CALCR_RAT", "url": "https://www.uniprot.org/uniprot/P32214", "type": "external" } ], "mass": 60292.0, "length": 516, "protein_name": "Calcitonin receptor", "gene_name": "Calcr", "organism": "Rat", "refseq_name": "calcitonin receptor isoform 1a precursor", "refseq_ac": [ { "id": "NP_001029187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029187", "type": "external" } ], "gene_names_uniprotkb": "Calcr", "gene_names_refseq": "Calcr", "protein_names_uniprotkb": "Calcitonin receptor; C1A/C1B; CT-R", "protein_names_refseq": "C1A/C1B; CT-R; calcitonin receptor isoform 1a precursor", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (rno:116506); (R-RNO-419812)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15240697;22761571;24516262;24801386;8391477;8395656", "class_list": "", "function": "Calcitonin receptor mRNA expression declines with age on osteocytes. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells., [RefSeq, PubMed]; Variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent Herpes simplex encephalitis development., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P32213", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0004948 calcitonin receptor activity;GO:0032841 calcitonin binding;GO:0001635 calcitonin gene-related peptide receptor activity;GO:0097643 amylin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32214-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505J9-1", "uniprot_id": [ { "id": "ATAD1_RAT", "url": "https://www.uniprot.org/uniprot/Q505J9", "type": "external" } ], "mass": 40717.0, "length": 361, "protein_name": "Outer mitochondrial transmembrane helix translocase", "gene_name": "Atad1", "organism": "Rat", "refseq_name": "outer mitochondrial transmembrane helix translocase", "refseq_ac": [ { "id": "NP_001030174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030174", "type": "external" } ], "gene_names_uniprotkb": "Atad1; Npg6", "gene_names_refseq": "Ab2-088; Atad1", "protein_names_uniprotkb": "Outer mitochondrial transmembrane helix translocase; 7.4.2.-; ATPase family AAA domain-containing protein 1; Neuroprotective protein 6; Thorase", "protein_names_refseq": "ATPase family AAA domain-containing protein 1; neuroprotective protein 6; outer mitochondrial transmembrane helix translocase; thorase", "tax_id": 10116, "disease": "hyperekplexia 4 (Disease Ontology:DOID:0080581)", "pathway": " (rno:309532); (R-RNO-9603798)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21124846;21496646;29393594", "class_list": "", "function": "Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This study identifies an AAA+ ATPase that plays a critical role in regulating the surface expression of AMPAR and thereby regulates synaptic plasticity and learning and memory., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3STU2", "ec_number_list": [ { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140567 membrane protein dislocase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0045211 postsynaptic membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0002092 positive regulation of receptor internalization;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q505J9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56405-1", "uniprot_id": [ { "id": "AQP8_RAT", "url": "https://www.uniprot.org/uniprot/P56405", "type": "external" } ], "mass": 28055.0, "length": 263, "protein_name": "Aquaporin-8", "gene_name": "Aqp8", "organism": "Rat", "refseq_name": "aquaporin-8 isoform 2", "refseq_ac": [ { "id": "NP_062031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062031", "type": "external" } ], "gene_names_uniprotkb": "Aqp8", "gene_names_refseq": "AQP-8; Aqp8", "protein_names_uniprotkb": "Aquaporin-8; AQP-8", "protein_names_refseq": "aquaporin-8 isoform 2", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:29172); (R-RNO-432047)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "11205061;11278499;11369592;11436986;12774023;15749715;15948717;15988592;16177191;16311720;16624991;17189259;18059526;20132793;22622463;23299935;28525373;30579780;31372390;32115689;33892285;9299432;9374520", "class_list": "", "function": "AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells., [RefSeq, PubMed]; Aquaporin 8 is involved in H2 O2 -mediated differential regulation of metabolic signaling by alpha1 - and beta-adrenoceptors in hepatocytes., [RefSeq, PubMed]; Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:12774023, PubMed:15749715, PubMed:15948717, PubMed:15988592, PubMed:16177191, PubMed:16624991, PubMed:17189259, PubMed:18059526, PubMed:20132793, PubMed:23299935, PubMed:31372390, PubMed:33892285, PubMed:9299432, PubMed:9374520). The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (PubMed:15988592). However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (PubMed:15988592). Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (PubMed:15749715, PubMed:15948717, PubMed:15988592). Does not transport urea or glycerol (PubMed:15948717). The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:18059526, PubMed:20132793, PubMed:9299432, PubMed:9374520). At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity). In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (PubMed:20132793, PubMed:23299935, PubMed:31372390). In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (By similarity). In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (PubMed:15749715, PubMed:16177191, PubMed:18059526). May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Liquid water metabolic abnormalities and intestine permeability might be the mechanism of IBS by regulating AQP1, AQP3 and AQP8 via NF-kappaB pathway., [RefSeq, PubMed]; Mitochondrial AQP8 is involved in SREBP2-controlled hepatocyte cholesterol biosynthesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015250 water channel activity;GO:0015265 urea channel activity;GO:0008519 ammonium channel activity;GO:0015264 methylammonium channel activity", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0015722 canalicular bile acid transport;GO:0045540 regulation of cholesterol biosynthetic process;GO:0030183 B cell differentiation;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P56405-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0H5-1", "uniprot_id": [ { "id": "CCNL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0H5", "type": "external" } ], "mass": 58246.0, "length": 520, "protein_name": "Cyclin-L2", "gene_name": "Aurkaip1; Ccnl2", "organism": "Rat", "refseq_name": "cyclin-L2 isoform 1", "refseq_ac": [ { "id": "NP_001388234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388234", "type": "external" } ], "gene_names_uniprotkb": "Aurkaip1; Ccnl2; Aurkaip1; Ccnl2", "gene_names_refseq": "Ccnl2", "protein_names_uniprotkb": "Cyclin-L2", "protein_names_refseq": "cyclin-L2 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298686)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulatory component of the cyclin-L-CDK11 complex that regulates transcription and pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0180038 cyclin L-CDK11 complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566E6-1", "uniprot_id": [ { "id": "CLM1_RAT", "url": "https://www.uniprot.org/uniprot/Q566E6", "type": "external" } ], "mass": 36823.0, "length": 332, "protein_name": "CMRF35-like molecule 1", "gene_name": "Cd300lf", "organism": "Rat", "refseq_name": "CMRF35-like molecule 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001020282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020282", "type": "external" } ], "gene_names_uniprotkb": "Cd300lf; Clm1", "gene_names_refseq": "CD300f; CLM-1; Cd300lf; RGD1309733", "protein_names_uniprotkb": "CMRF35-like molecule 1; CD300 antigen-like family member F; CLM-1", "protein_names_refseq": "CD300 antigen-like family member F; CMRF35-like molecule 1 isoform 2 precursor; CMRF35-like molecule 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287818); (R-RNO-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding;GO:0097001 ceramide binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway;GO:1902216 positive regulation of interleukin-4-mediated signaling pathway;GO:2000426 negative regulation of apoptotic cell clearance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q566E6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63100-1", "uniprot_id": [ { "id": "CANB1_RAT", "url": "https://www.uniprot.org/uniprot/P63100", "type": "external" } ], "mass": 19300.0, "length": 170, "protein_name": "Calcineurin subunit B type 1", "gene_name": "ENSRNOG00000065686; Ppp3r1", "organism": "Rat", "refseq_name": "calcineurin subunit B type 1", "refseq_ac": [ { "id": "NP_059005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059005", "type": "external" } ], "gene_names_uniprotkb": "ENSRNOG00000065686; Ppp3r1; Cna2; Cnb; Ppp3r1", "gene_names_refseq": "Ppp3r1", "protein_names_uniprotkb": "Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1", "protein_names_refseq": "calcineurin subunit B type 1; protein phosphatase 2B regulatory subunit 1", "tax_id": 10116, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29748); (R-RNO-111447); (R-RNO-2025928); (R-RNO-2871809); (R-RNO-4086398); (R-RNO-5607763)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "12135494;24018048;29973623;34791930;8110831", "class_list": "", "function": "Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmission at the Spinal Cord Level. Review article, [RefSeq, PubMed]; Ppp3r1 mRNA and protein are decreased in the hypercholesterolemic heart. Erratum:[Sci Rep. 2018 Aug 9;8(1):12159. doi: 10.1038/s41598-018-30163-9. PMID: 30089810] Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The enzymatic properties of CaN heterodimers comprised of the regulatory B subunit (CnB) with either the alpha or beta catalytic subunit were compared using in vitro phosphatase assays., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06705;P15117;Q08044", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0005955 calcineurin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0033173 calcineurin-NFAT signaling cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZU1-1", "uniprot_id": [ { "id": "COQ4_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZU1", "type": "external" } ], "mass": 30013.0, "length": 265, "protein_name": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "gene_name": "Coq4", "organism": "Rat", "refseq_name": "ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001026832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026832", "type": "external" } ], "gene_names_uniprotkb": "Coq4; COQ4", "gene_names_refseq": "Coq4", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; 4.1.1.130; Coenzyme Q biosynthesis protein 4 homolog", "protein_names_refseq": "4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase; coenzyme Q biosynthesis protein 4 homolog; coenzyme Q4 homolog; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); spastic ataxia (Disease Ontology:DOID:0050952); primary coenzyme Q10 deficiency 7 (Disease Ontology:DOID:0070244)", "pathway": " (rno:366013); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid into 2-methoxy-6-(all-trans-decaprenyl)phenol during ubiquinone biosynthesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0120539 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032991 protein-containing complex;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZU1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32ZI2-1", "uniprot_id": [ { "id": "DEFB9_RAT", "url": "https://www.uniprot.org/uniprot/Q32ZI2", "type": "external" } ], "mass": 8317.0, "length": 71, "protein_name": "Beta-defensin 9", "gene_name": "Defb9", "organism": "Rat", "refseq_name": "beta-defensin 9 precursor", "refseq_ac": [ { "id": "NP_001032598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032598", "type": "external" } ], "gene_names_uniprotkb": "Defb9", "gene_names_refseq": "Defb9", "protein_names_uniprotkb": "Beta-defensin 9; BD-9; Defensin, beta 9", "protein_names_refseq": "BD-9; beta-defensin 9 precursor; beta-defensin 9", "tax_id": 10116, "disease": "", "pathway": " (rno:641633)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32ZI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499T7-1", "uniprot_id": [ { "id": "CFA20_RAT", "url": "https://www.uniprot.org/uniprot/Q499T7", "type": "external" } ], "mass": 19132.0, "length": 164, "protein_name": "Cilia- and flagella-associated protein 20", "gene_name": "Cfap20", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 20 isoform 2", "refseq_ac": [ { "id": "NP_001033067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033067", "type": "external" } ], "gene_names_uniprotkb": "Cfap20; Gtl3", "gene_names_refseq": "Cfap20; Gtl3", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 20; Gene trap locus 3 protein homolog", "protein_names_refseq": "UPF0468 protein C16orf80 homolog; cilia- and flagella-associated protein 20 isoform 2; gene trap locus 3 protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307642)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly;GO:2000253 positive regulation of feeding behavior;GO:2000147 positive regulation of cell motility;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499T7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1S9-1", "uniprot_id": [ { "id": "DGLB_RAT", "url": "https://www.uniprot.org/uniprot/P0C1S9", "type": "external" } ], "mass": 73771.0, "length": 668, "protein_name": "Diacylglycerol lipase-beta", "gene_name": "Daglb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Daglb", "gene_names_refseq": "", "protein_names_uniprotkb": "Diacylglycerol lipase-beta; 3.1.1.116; 3.1.1.3; DAGL-beta; DGL-beta; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:304289); (R-RNO-426048)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16051747", "class_list": "", "function": "Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (By similarity). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006690 icosanoid metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0045471 response to ethanol;GO:0050727 regulation of inflammatory response;GO:0046340 diacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C1S9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZAV0-1", "uniprot_id": [ { "id": "CCD60_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZAV0", "type": "external" } ], "mass": 62503.0, "length": 542, "protein_name": "Coiled-coil domain-containing protein 60", "gene_name": "Ccdc60", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 60 isoform 2", "refseq_ac": [ { "id": "NP_001030117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030117", "type": "external" } ], "gene_names_uniprotkb": "Ccdc60", "gene_names_refseq": "Ccdc60", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 60", "protein_names_refseq": "coiled-coil domain-containing protein 60 isoform 2; coiled-coil domain-containing protein 60", "tax_id": 10116, "disease": "", "pathway": " (rno:498190)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZAV0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19223-1", "uniprot_id": [ { "id": "CBPB1_RAT", "url": "https://www.uniprot.org/uniprot/P19223", "type": "external" } ], "mass": 47515.0, "length": 415, "protein_name": "Carboxypeptidase B", "gene_name": "Cpb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cpb1; Cpb", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxypeptidase B; 3.4.17.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-2022377)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1898371;3182872", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2", "type": "external" }, { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031410 cytoplasmic vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19223-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26051-1", "uniprot_id": [ { "id": "CD44_RAT", "url": "https://www.uniprot.org/uniprot/P26051", "type": "external" } ], "mass": 55946.0, "length": 503, "protein_name": "CD44 antigen", "gene_name": "Cd44", "organism": "Rat", "refseq_name": "CD44 antigen isoform X12", "refseq_ac": [ { "id": "XP_006234693", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234693", "type": "external" } ], "gene_names_uniprotkb": "Cd44", "gene_names_refseq": "CD44A; Cd44; METAA; RHAMM", "protein_names_uniprotkb": "CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I", "protein_names_refseq": "CD44 antigen isoform X12", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); cholestasis (Disease Ontology:DOID:13580); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); breast ductal carcinoma (Disease Ontology:DOID:3007); invasive ductal carcinoma (Disease Ontology:DOID:3008); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); leiomyomatosis (Disease Ontology:DOID:5138); borna disease (Disease Ontology:DOID:5154); Krukenberg carcinoma (Disease Ontology:DOID:9597)", "pathway": " (R-RNO-1474228); (R-RNO-202733); (R-RNO-2142845); (R-RNO-216083); (R-RNO-2160916); (R-RNO-6798695)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "1707342;22673903;9692903", "class_list": "", "function": "Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 8, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q99021", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0005154 epidermal growth factor receptor binding;GO:0005114 type II transforming growth factor beta receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0002246 wound healing involved in inflammatory response;GO:0006897 endocytosis;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26051-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14173-1", "uniprot_id": [ { "id": "DDC_RAT", "url": "https://www.uniprot.org/uniprot/P14173", "type": "external" } ], "mass": 54053.0, "length": 480, "protein_name": "Aromatic-L-amino-acid decarboxylase", "gene_name": "Ddc", "organism": "Rat", "refseq_name": "aromatic-L-amino-acid decarboxylase isoform a", "refseq_ac": [ { "id": "NP_001257781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257781", "type": "external" } ], "gene_names_uniprotkb": "Ddc", "gene_names_refseq": "AADC; Ddc", "protein_names_uniprotkb": "Aromatic-L-amino-acid decarboxylase; 4.1.1.28; AADC; DDC; DOPA decarboxylase", "protein_names_refseq": "L-Dopa decarboxylase; aromatic-L-amino-acid decarboxylase isoform a; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); aromatic L-amino acid decarboxylase deficiency (Disease Ontology:DOID:0090123); portal hypertension (Disease Ontology:DOID:10762); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); hyperinsulinism (Disease Ontology:DOID:2018); bipolar disorder (Disease Ontology:DOID:3312); primary ovarian insufficiency (Disease Ontology:DOID:5426); inherited metabolic disorder (Disease Ontology:DOID:655); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:24311); (R-RNO-209905); (R-RNO-209931)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11358515;1465439;22829864;2813383;36768816;8889823", "class_list": "", "function": "Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms. Publication Status: Online-Only, [RefSeq, PubMed]; The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LEG4", "ec_number_list": [ { "id": "4.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.28", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030170 pyridoxal phosphate binding;GO:0016597 amino acid binding;GO:0004058 aromatic-L-amino-acid decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0001822 kidney development;GO:0071466 cellular response to xenobiotic stimulus;GO:0071363 cellular response to growth factor stimulus;GO:0007623 circadian rhythm;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14173-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8Q1-1", "uniprot_id": [ { "id": "CAN11_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8Q1", "type": "external" } ], "mass": 83241.0, "length": 716, "protein_name": "Calpain 11", "gene_name": "Capn11", "organism": "Rat", "refseq_name": "calpain 11", "refseq_ac": [ { "id": "NP_001002806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002806", "type": "external" } ], "gene_names_uniprotkb": "Capn11", "gene_names_refseq": "Capn11", "protein_names_uniprotkb": "Calpain 11; 3.4.22.-; CANP 11; Calcium-activated neutral proteinase 11", "protein_names_refseq": "CANP 11; calcium-activated neutral proteinase 11; calpain 11", "tax_id": 10116, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:408218); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IE72", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8Q1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27732-1", "uniprot_id": [ { "id": "CAC1D_RAT", "url": "https://www.uniprot.org/uniprot/P27732", "type": "external" } ], "mass": 250136.0, "length": 2203, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1D", "gene_name": "Cacna1d", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1d; Cach3; Cacn4; Cacnl1a2; Cchl1a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1D; Calcium channel, L type, alpha-1 polypeptide, isoform 2; RBD; Rat brain class D; Voltage-gated calcium channel subunit alpha Cav1.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-422356)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1279681;1648940;1692134;17050707;7479909;7553731;7760845;9232351", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O09022;O09023;O09024;Q01542;Q62691;Q62815;Q63491;Q63492", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding;GO:0030165 PDZ domain binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007507 heart development;GO:0007613 memory;GO:0019722 calcium-mediated signaling;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27732-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04589-1", "uniprot_id": [ { "id": "FGFR1_RAT", "url": "https://www.uniprot.org/uniprot/Q04589", "type": "external" } ], "mass": 91825.0, "length": 822, "protein_name": "Fibroblast growth factor receptor 1", "gene_name": "Fgfr1", "organism": "Rat", "refseq_name": "fibroblast growth factor receptor 1 precursor", "refseq_ac": [ { "id": "NP_077060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077060", "type": "external" } ], "gene_names_uniprotkb": "Fgfr1; Flg", "gene_names_refseq": "FGFR-1; Fgfr1; MFR; bFGF-R-1; bFGF-R; c-fgr", "protein_names_uniprotkb": "Fibroblast growth factor receptor 1; 2.7.10.1; Basic fibroblast growth factor receptor 1; FGFR-1; MFR; Proto-oncogene c-Fgr; bFGF-R-1", "protein_names_refseq": "FGF receptor-1; basic fibroblast growth factor receptor 1; fibroblast growth factor receptor 1 precursor; proto-oncogene c-Fgr", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); atypical chronic myeloid leukemia, BCR-ABL1 negative (Disease Ontology:DOID:0060597); myeloid neoplasm (Disease Ontology:DOID:0070004); bone disease (Disease Ontology:DOID:0080001); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); hypogonadotropic hypogonadism 7 with or without anosmia (Disease Ontology:DOID:0090078); hypogonadotropic hypogonadism 2 with or without anosmia (Disease Ontology:DOID:0090083); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); osteoglophonic dysplasia (Disease Ontology:DOID:0111532); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); sciatic neuropathy (Disease Ontology:DOID:11446); acoustic neuroma (Disease Ontology:DOID:12689); acrocephalosyndactylia (Disease Ontology:DOID:12960); Pfeiffer syndrome (Disease Ontology:DOID:14705); transient cerebral ischemia (Disease Ontology:DOID:224); high grade glioma (Disease Ontology:DOID:3070); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mouth disease (Disease Ontology:DOID:403); renal cell carcinoma (Disease Ontology:DOID:4450); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); fibrolamellar carcinoma (Disease Ontology:DOID:5015); retinal detachment (Disease Ontology:DOID:5327); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); cleft lip (Disease Ontology:DOID:9296); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:79114); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190370); (R-RNO-190373); (R-RNO-190374); (R-RNO-445144); (R-RNO-5654219); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654726); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 15, "publication_count": 12, "publication_id_list": "15117958;17992255;19224897;22673903;23564461;28701747;32278061;33470768;34685716;7516330;8382532;8622701", "class_list": "", "function": "A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats., [RefSeq, PubMed]; Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001759 organ induction;GO:0010966 regulation of phosphate transport;GO:0051174 regulation of phosphorus metabolic process;GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:1904383 response to sodium phosphate", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q04589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58366-1", "uniprot_id": [ { "id": "ANKH_RAT", "url": "https://www.uniprot.org/uniprot/P58366", "type": "external" } ], "mass": 54265.0, "length": 492, "protein_name": "Mineralization regulator ANKH", "gene_name": "Ankh", "organism": "Rat", "refseq_name": "mineralization regulator ANKH", "refseq_ac": [ { "id": "NP_446166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446166", "type": "external" } ], "gene_names_uniprotkb": "Ankh; Ank", "gene_names_refseq": "Ankh; Ank; SLC61A1", "protein_names_uniprotkb": "Mineralization regulator ANKH; ANK; ATP carrier protein ANKH; Progressive ankylosis protein homolog", "protein_names_refseq": "ATP carrier protein ANKH; ankylosis, progressive homolog; mineralization regulator ANKH; progressive ankylosis homolog; progressive ankylosis protein homolog; solute carrier family 61 member 1", "tax_id": 10116, "disease": "craniometaphyseal dysplasia (Disease Ontology:DOID:0080033); autosomal dominant craniometaphyseal dysplasia (Disease Ontology:DOID:0080801); chondrocalcinosis (Disease Ontology:DOID:1156)", "pathway": " (rno:114506); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22437419;22695244;24065227;31356809", "class_list": "", "function": "Phosphorylation of JNK promotes natural degeneration of cervical endplate chondrocytes, likely by down-regulating ANK expression, [RefSeq, PubMed]; Results show that Cyclic Mechanical Tension (ICMT) induced the calcification and downregulation of ankh gene expression of end plate chondrocytes., [RefSeq, PubMed]; TNF-activated NF-kappaB promotes inflammation-accelerated vascular calcification by inhibiting ankylosis protein homolog expression and consequent pyrophosphate secretion., [RefSeq, PubMed]; This work reveals the ANKH regulation of Wnt1 in vascular smooth muscle cells is essential for blocking vascular calcification (VC). Our findings may contribute to the development of medications that target Wnt signaling and/or ANKH to inhibit VC., [RefSeq, PubMed]; Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030500 regulation of bone mineralization;GO:0006817 phosphate ion transport;GO:0035435 phosphate ion transmembrane transport;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P58366-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17084-1", "uniprot_id": [ { "id": "COL_RAT", "url": "https://www.uniprot.org/uniprot/P17084", "type": "external" } ], "mass": 12252.0, "length": 112, "protein_name": "Colipase", "gene_name": "Clps", "organism": "Rat", "refseq_name": "colipase precursor", "refseq_ac": [ { "id": "NP_037271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037271", "type": "external" } ], "gene_names_uniprotkb": "Clps", "gene_names_refseq": "COLQ; Clps", "protein_names_uniprotkb": "Colipase", "protein_names_refseq": "colipase precursor; colipase, pancreatic", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583); colon carcinoma (Disease Ontology:DOID:1520); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung carcinoma (Disease Ontology:DOID:3905); skin cancer (Disease Ontology:DOID:4159); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25680); (R-RNO-192456); (R-RNO-975634)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2129524;8203536", "class_list": "", "function": "Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Enterostatin has a biological activity as a satiety signal., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0016042 lipid catabolic process;GO:0032094 response to food;GO:0043085 positive regulation of catalytic activity;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17084-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49621-1", "uniprot_id": [ { "id": "DGKB_RAT", "url": "https://www.uniprot.org/uniprot/P49621", "type": "external" } ], "mass": 90288.0, "length": 801, "protein_name": "Diacylglycerol kinase beta", "gene_name": "Dgkb", "organism": "Rat", "refseq_name": "diacylglycerol kinase beta", "refseq_ac": [ { "id": "NP_062177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062177", "type": "external" } ], "gene_names_uniprotkb": "Dgkb; Dagk2", "gene_names_refseq": "DGK-beta; Dagk; Dgkb", "protein_names_uniprotkb": "Diacylglycerol kinase beta; 2.7.1.107; 90 kDa diacylglycerol kinase; DAG kinase beta; DGK-beta; Diglyceride kinase beta", "protein_names_refseq": "90 kDa diacylglycerol kinase; DAG kinase beta; Diacylglycerol kinase 90kDa; diacylglycerol kinase beta, 90kDa; diacylglycerol kinase beta; diglyceride kinase beta", "tax_id": 10116, "disease": "atrioventricular block (Disease Ontology:DOID:0050820); congenital nongoitrous hypothyroidism 5 (Disease Ontology:DOID:0070125); aortic valve disease 2 (Disease Ontology:DOID:0080334); atrial heart septal defect 7 (Disease Ontology:DOID:0110112); ventricular septal defect (Disease Ontology:DOID:1657); heart septal defect (Disease Ontology:DOID:1681); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); pulmonary fibrosis (Disease Ontology:DOID:3770); glucose metabolism disease (Disease Ontology:DOID:4194); tetralogy of Fallot (Disease Ontology:DOID:6419); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:54248); (R-RNO-114508)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15896305;22673903;23467923;23503970;23949095;7689223", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:23949095, PubMed:7689223). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (PubMed:7689223). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The DGKbeta localize in the outer plexiform layer, within which photoreceptor cells make contact with bipolar and horizontal cells., [RefSeq, PubMed]; These results suggest that DGKepsilon and DGKzeta play distinct roles in the development of pressure overloaded cardiac hypertrophy and that the two isozymes are differentially regulated., [RefSeq, PubMed]; This study demonistrated that dgkb distribuate in rat cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098685 Schaffer collateral - CA1 synapse;GO:0099147 extrinsic component of postsynaptic density membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49621-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569C1-1", "uniprot_id": [ { "id": "CHM4C_RAT", "url": "https://www.uniprot.org/uniprot/Q569C1", "type": "external" } ], "mass": 26324.0, "length": 232, "protein_name": "Charged multivesicular body protein 4c", "gene_name": "Chmp4c", "organism": "Rat", "refseq_name": "charged multivesicular body protein 4c", "refseq_ac": [ { "id": "NP_001017466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017466", "type": "external" } ], "gene_names_uniprotkb": "Chmp4c", "gene_names_refseq": "Chmp4c", "protein_names_uniprotkb": "Charged multivesicular body protein 4c; CHMP4c; Chromatin-modifying protein 4c", "protein_names_refseq": "Snf7 homologue associated with Alix 3; charged multivesicular body protein 4c; chromatin modifying protein 4C; chromatin-modifying protein 4c", "tax_id": 10116, "disease": "", "pathway": " (rno:361916); (R-RNO-1632852); (R-RNO-5620971); (R-RNO-917729); (R-RNO-9668328)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "37846580", "class_list": "", "function": "ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by Targeting the Endo-Lysosomal Degradation of EGFR., [RefSeq, PubMed]; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: upon phosphorylation by AURKB, together with ZFYVE19/ANCHR, retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ANCHR and VPS4 and subsequent abscission. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q569C1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02294-1", "uniprot_id": [ { "id": "CAC1B_RAT", "url": "https://www.uniprot.org/uniprot/Q02294", "type": "external" } ], "mass": 262256.0, "length": 2336, "protein_name": "Voltage-dependent N-type calcium channel subunit alpha-1B", "gene_name": "Cacna1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1b; Cach5; Cacnl1a5", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent N-type calcium channel subunit alpha-1B; BIII; Brain calcium channel III; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); brain edema (Disease Ontology:DOID:4724); migraine (Disease Ontology:DOID:6364)", "pathway": " (R-RNO-112308)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10938268;1317580;1692134;22673903;23699505;38843836;7509046;8125957", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0051721 protein phosphatase 2A binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007626 locomotory behavior;GO:0045471 response to ethanol;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q02294-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97696-1", "uniprot_id": [ { "id": "CYH3_RAT", "url": "https://www.uniprot.org/uniprot/P97696", "type": "external" } ], "mass": 46337.0, "length": 400, "protein_name": "Cytohesin-3", "gene_name": "Cyth3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyth3; Pscd3; Sec7c", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytohesin-3; PH, SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; rSec7-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:116693); (R-RNO-6811438)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11834294;9352219", "class_list": "", "function": "Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0016192 vesicle-mediated transport;GO:0090162 establishment of epithelial cell polarity;GO:0048193 Golgi vesicle transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97696-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55280-1", "uniprot_id": [ { "id": "CADH6_RAT", "url": "https://www.uniprot.org/uniprot/P55280", "type": "external" } ], "mass": 88341.0, "length": 789, "protein_name": "Cadherin-6", "gene_name": "Cdh6", "organism": "Rat", "refseq_name": "cadherin-6 precursor", "refseq_ac": [ { "id": "NP_037059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037059", "type": "external" } ], "gene_names_uniprotkb": "Cdh6; Kcad", "gene_names_refseq": "Cdh6; KCAD", "protein_names_uniprotkb": "Cadherin-6; K-cadherin; Kidney cadherin", "protein_names_refseq": "K-cadherin; cadherin 6, type 2, K-cadherin; cadherin-6 precursor; kidney cadherin", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:25409); (R-RNO-418990)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1039/D0MO00044B;11803548;22673903;34106099;8187093", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB, UniProtKB]; Expressed throughout prepubertal ovarian development, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0030054 cell junction;GO:0045202 synapse", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55280-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06760-1", "uniprot_id": [ { "id": "BGLR_RAT", "url": "https://www.uniprot.org/uniprot/P06760", "type": "external" } ], "mass": 74793.0, "length": 648, "protein_name": "Beta-glucuronidase", "gene_name": "Gusb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gusb; Gus", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-glucuronidase; 3.2.1.31", "protein_names_refseq": "", "tax_id": 10116, "disease": "mucopolysaccharidosis (Disease Ontology:DOID:12798); mucopolysaccharidosis type VII (Disease Ontology:DOID:12803); peritonitis (Disease Ontology:DOID:8283)", "pathway": " (rno:24434); (R-RNO-2024101); (R-RNO-2160916); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "3355537;3463967", "class_list": "glycogene;glycosylhydrolase", "function": "Plays an important role in the degradation of dermatan and keratan sulfates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding;GO:0030246 carbohydrate binding;GO:0004566 beta-glucuronidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1904888 cranial skeletal system development;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003415 chondrocyte hypertrophy;GO:0001523 retinoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P06760-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30551-1", "uniprot_id": [ { "id": "CCKAR_RAT", "url": "https://www.uniprot.org/uniprot/P30551", "type": "external" } ], "mass": 49657.0, "length": 444, "protein_name": "Cholecystokinin receptor type A", "gene_name": "Cckar", "organism": "Rat", "refseq_name": "cholecystokinin receptor type A", "refseq_ac": [ { "id": "NP_036820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036820", "type": "external" } ], "gene_names_uniprotkb": "Cckar", "gene_names_refseq": "Cck-ar; Cckar", "protein_names_uniprotkb": "Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; CCK1-R; Cholecystokinin-1 receptor", "protein_names_refseq": "CCK-A receptor; CCK1-R; cholecystokinin receptor type A; cholecystokinin-1 receptor", "tax_id": 10116, "disease": "cholelithiasis (Disease Ontology:DOID:10211); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24889); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12916469;1313582;24978951;32699194;33422646;35691467;37298724;7654260;8024583", "class_list": "", "function": "Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Satiety induced by bile acids is mediated via vagal afferent pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade. Erratum:[J Pain. 2024 Nov;25(11):104650. doi: 10.1016/j.jpain.2024.104650. PMID: 39283282], [RefSeq, PubMed]; The critical role of CCK in the regulation of food intake and diet-induced obesity. Review article, [RefSeq, PubMed]; This study demonistrated that Cckar and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004951 cholecystokinin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0001659 temperature homeostasis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30551-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43527-1", "uniprot_id": [ { "id": "CASP1_RAT", "url": "https://www.uniprot.org/uniprot/P43527", "type": "external" } ], "mass": 45576.0, "length": 402, "protein_name": "Caspase-1", "gene_name": "Casp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Casp1; Il1bce; Il1bc", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase-1; 3.4.22.36; CASP-1; ICE; IL-1 beta-converting enzyme; IL-1BC; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (R-RNO-168638); (R-RNO-448706); (R-RNO-5620971); (R-RNO-9968551)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "7588240;7780029", "class_list": "", "function": "Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0097110 scaffold protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0032741 positive regulation of interleukin-18 production;GO:0001774 microglial cell activation;GO:0006508 proteolysis;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43527-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35859-1", "uniprot_id": [ { "id": "ALS_RAT", "url": "https://www.uniprot.org/uniprot/P35859", "type": "external" } ], "mass": 66812.0, "length": 603, "protein_name": "Insulin-like growth factor-binding protein complex acid labile subunit", "gene_name": "Igfals", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein complex acid labile subunit precursor", "refseq_ac": [ { "id": "NP_445781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445781", "type": "external" } ], "gene_names_uniprotkb": "Igfals; Als", "gene_names_refseq": "Als; Igfals", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein complex acid labile subunit; ALS", "protein_names_refseq": "insulin-like growth factor-binding protein complex acid labile chain; insulin-like growth factor-binding protein complex acid labile subunit precursor; insulin-like growth factor-binding protein complex acid labile subunit", "tax_id": 10116, "disease": "isolated growth hormone deficiency (Disease Ontology:DOID:0060870); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); nephrotic syndrome (Disease Ontology:DOID:1184); Noonan syndrome (Disease Ontology:DOID:3490); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (rno:79438); (R-RNO-381426)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1384485;7507839", "class_list": "", "function": "May have an important role in regulating the access of circulating IGFs to the tissues., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0042567 insulin-like growth factor ternary complex", "go_biological_process": "GO:0071378 cellular response to growth hormone stimulus;GO:0007155 cell adhesion;GO:0031667 response to nutrient levels;GO:0071549 cellular response to dexamethasone stimulus;GO:0071364 cellular response to epidermal growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35859-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97528-1", "uniprot_id": [ { "id": "CNTN6_RAT", "url": "https://www.uniprot.org/uniprot/P97528", "type": "external" } ], "mass": 114065.0, "length": 1028, "protein_name": "Contactin-6", "gene_name": "Cntn6", "organism": "Rat", "refseq_name": "contactin-6 precursor", "refseq_ac": [ { "id": "NP_037357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037357", "type": "external" } ], "gene_names_uniprotkb": "Cntn6", "gene_names_refseq": "Cntn6; NB-3", "protein_names_uniprotkb": "Contactin-6; Neural recognition molecule NB-3", "protein_names_refseq": "contactin-6 precursor; neural adhesion molecule; neural recognition molecule NB-3", "tax_id": 10116, "disease": "", "pathway": " (rno:27256)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12884264;15082708;8945756", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. May be involved in motor coordination., [UniProtKB, PubMed]; Immunohistochemistry of the cerebellum from 3-month-old rats demonstrates that lobules 1-8 are distinct from lobules 9 and 10 with respect to localization of NB-3 protein., [RefSeq, PubMed]; NB-3/Notch1 pathway promotes neural progenitor cell differentiation into oligodendrocytes via Deltex1., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0042734 presynaptic membrane;GO:0098793 presynapse;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007219 Notch signaling pathway;GO:0031175 neuron projection development;GO:0045747 positive regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97528-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C927-1", "uniprot_id": [ { "id": "ASB14_RAT", "url": "https://www.uniprot.org/uniprot/P0C927", "type": "external" } ], "mass": 66181.0, "length": 596, "protein_name": "Ankyrin repeat and SOCS box protein 14", "gene_name": "Asb14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Asb14", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box protein 14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:680076); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a role in the inhibition of cardiomyocyte nuclear proliferation by mediating the ubiquitination and degradation of MAPRE2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C927-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1WIM1-1", "uniprot_id": [ { "id": "CADM4_RAT", "url": "https://www.uniprot.org/uniprot/Q1WIM1", "type": "external" } ], "mass": 42781.0, "length": 388, "protein_name": "Cell adhesion molecule 4", "gene_name": "Cadm4", "organism": "Rat", "refseq_name": "cell adhesion molecule 4 precursor", "refseq_ac": [ { "id": "NP_001040572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040572", "type": "external" } ], "gene_names_uniprotkb": "Cadm4; Igsf4c; Necl4", "gene_names_refseq": "Cadm4; Igsf4c; Necl-4; Upar", "protein_names_uniprotkb": "Cell adhesion molecule 4; IgSF4C; Immunoglobulin superfamily member 4C; NECL-4; Nectin-like protein 4", "protein_names_refseq": "cell adhesion molecule 4 precursor; immunoglobulin superfamily, member 4C; nectin-like protein 4; urokinase plasminogen activator receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:365216)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17558405;17724124;22673903;24090084;28119456", "class_list": "", "function": "Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity. In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG. May have tumor-suppressor activity., [UniProtKB, UniProtKB, UniProtKB]; Intracellular choline levels are significantly elevated in NECL4-deficient Schwann cells., [RefSeq, PubMed]; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Necl4 protein is important for mediating axon-glia contact during myelination in peripheral nerves, [RefSeq, PubMed]; These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 164, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding;GO:0043184 vascular endothelial growth factor receptor 2 binding", "go_cellular_component": "GO:0031252 cell leading edge;GO:0097060 synaptic membrane;GO:0044291 cell-cell contact zone;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0061041 regulation of wound healing;GO:0042127 regulation of cell population proliferation;GO:2000145 regulation of cell motility;GO:0001933 negative regulation of protein phosphorylation;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q1WIM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8C8-1", "uniprot_id": [ { "id": "CDC73_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8C8", "type": "external" } ], "mass": 60603.0, "length": 531, "protein_name": "Parafibromin", "gene_name": "Cdc73", "organism": "Rat", "refseq_name": "parafibromin", "refseq_ac": [ { "id": "NP_001019940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019940", "type": "external" } ], "gene_names_uniprotkb": "Cdc73; Hrpt2", "gene_names_refseq": "Cdc73; Hrpt2", "protein_names_uniprotkb": "Parafibromin; Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein homolog", "protein_names_refseq": "cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 protein homolog; parafibromin", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hyperparathyroidism (Disease Ontology:DOID:13543); parathyroid carcinoma (Disease Ontology:DOID:1540); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:304832); (R-RNO-112382); (R-RNO-201722); (R-RNO-5632684); (R-RNO-674695); (R-RNO-75955); (R-RNO-8866654); (R-RNO-9943411)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8C8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37996-1", "uniprot_id": [ { "id": "ARL3_RAT", "url": "https://www.uniprot.org/uniprot/P37996", "type": "external" } ], "mass": 20457.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "Arl3", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 3", "refseq_ac": [ { "id": "NP_073191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073191", "type": "external" } ], "gene_names_uniprotkb": "Arl3", "gene_names_refseq": "Arl3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3; ARD3", "protein_names_refseq": "ADP ribosylation factor like GTPase 3; ADP-ribosylation factor-like 3; ADP-ribosylation factor-like protein 3; ADP-ribosylation-like 3; ARD3", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); retinitis pigmentosa 83 (Disease Ontology:DOID:0112140)", "pathway": " (rno:64664); (R-RNO-5624138)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8034651", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0001822 kidney development;GO:0007264 small GTPase-mediated signal transduction;GO:0060271 cilium assembly;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P37996-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30940-1", "uniprot_id": [ { "id": "5HT1F_RAT", "url": "https://www.uniprot.org/uniprot/P30940", "type": "external" } ], "mass": 41880.0, "length": 366, "protein_name": "5-hydroxytryptamine receptor 1F", "gene_name": "Htr1f", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Htr1f; 5ht1f", "gene_names_refseq": "", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1F; 5-HT-1F; 5-HT1F; Serotonin receptor 1F", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:60448); (R-RNO-390666); (R-RNO-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8384716", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8384716). Also functions as a receptor for various alkaloids and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001586 Gi/o-coupled serotonin receptor activity;GO:0099589 serotonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30940-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97707-1", "uniprot_id": [ { "id": "CCG1_RAT", "url": "https://www.uniprot.org/uniprot/P97707", "type": "external" } ], "mass": 25119.0, "length": 223, "protein_name": "Voltage-dependent calcium channel gamma-1 subunit", "gene_name": "Cacng1", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-1 subunit", "refseq_ac": [ { "id": "NP_062128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062128", "type": "external" } ], "gene_names_uniprotkb": "Cacng1", "gene_names_refseq": "Cacng1; Cacng", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma", "protein_names_refseq": "calcium channel, voltage-dependent, gamma subunit 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; voltage-dependent calcium channel gamma-1 subunit", "tax_id": 10116, "disease": "malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (rno:29658)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9049149", "class_list": "", "function": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0030315 T-tubule;GO:1990454 L-type voltage-gated calcium channel complex;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0070588 calcium ion transmembrane transport;GO:0070296 sarcoplasmic reticulum calcium ion transport;GO:0034762 regulation of transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97707-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48769-1", "uniprot_id": [ { "id": "DCK_RAT", "url": "https://www.uniprot.org/uniprot/P48769", "type": "external" } ], "mass": 30406.0, "length": 260, "protein_name": "Deoxycytidine kinase", "gene_name": "Dck", "organism": "Rat", "refseq_name": "deoxycytidine kinase", "refseq_ac": [ { "id": "NP_077072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077072", "type": "external" } ], "gene_names_uniprotkb": "Dck", "gene_names_refseq": "Dck", "protein_names_uniprotkb": "Deoxycytidine kinase; 2.7.1.113; 2.7.1.74; 2.7.1.76; Deoxyadenosine kinase; Deoxyguanosine kinase; dCK", "protein_names_refseq": "deoxyadenosine kinase; deoxycytidine kinase; deoxyguanosine kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:79127); (R-RNO-73614); (R-RNO-74217)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20544526;22673903;7821805", "class_list": "", "function": "A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts., [RefSeq, PubMed]; Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.113", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.113", "type": "external" }, { "id": "2.7.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.76", "type": "external" }, { "id": "2.7.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.74", "type": "external" } ], "go_molecular_function": "GO:0004138 deoxyguanosine kinase activity;GO:0032548 pyrimidine deoxyribonucleoside binding;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046092 deoxycytidine metabolic process;GO:0032261 purine nucleotide salvage;GO:0006220 pyrimidine nucleotide metabolic process;GO:1901293 nucleoside phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97876-1", "uniprot_id": [ { "id": "BATF3_RAT", "url": "https://www.uniprot.org/uniprot/P97876", "type": "external" } ], "mass": 15129.0, "length": 133, "protein_name": "Basic leucine zipper transcriptional factor ATF-like 3", "gene_name": "Batf3", "organism": "Rat", "refseq_name": "basic leucine zipper transcriptional factor ATF-like 3", "refseq_ac": [ { "id": "NP_068637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068637", "type": "external" } ], "gene_names_uniprotkb": "Batf3; Jdp1", "gene_names_refseq": "Batf3; Jdp1", "protein_names_uniprotkb": "Basic leucine zipper transcriptional factor ATF-like 3; B-ATF-3; JDP-1; Jun dimerization protein 1", "protein_names_refseq": "B-ATF-3; JDP-1; Jun dimerization protein 1; basic leucine zipper transcription factor, ATF-like 3; basic leucine zipper transcriptional factor ATF-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:60462)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9154808", "class_list": "", "function": "AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0044877 protein-containing complex binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009615 response to virus;GO:0043011 myeloid dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41738-1", "uniprot_id": [ { "id": "AHR_RAT", "url": "https://www.uniprot.org/uniprot/P41738", "type": "external" } ], "mass": 96227.0, "length": 853, "protein_name": "Aryl hydrocarbon receptor", "gene_name": "Ahr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ahr", "gene_names_refseq": "", "protein_names_uniprotkb": "Aryl hydrocarbon receptor; Ah receptor; AhR", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); traumatic brain injury (Disease Ontology:DOID:0081292); neuronal ceroid lipofuscinosis 1 (Disease Ontology:DOID:0110721); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); retinitis pigmentosa 85 (Disease Ontology:DOID:0112142); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcoholic hepatitis (Disease Ontology:DOID:12351); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary hypertension (Disease Ontology:DOID:6432); congenital nystagmus (Disease Ontology:DOID:9649)", "pathway": " (rno:25690); (R-RNO-211945); (R-RNO-211976); (R-RNO-211981); (R-RNO-8937144)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11755109;12213388;7812217;8065918;9658193", "class_list": "", "function": "Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:7812217). Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation. Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists. Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands. Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-BMAL1 heterodimer mediated transcriptional activation of PER1.The heterodimer ARNT:AHR binds to the dioxin response element (DRE) of target gene promoters and activates their transcription (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88930;O89105", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0015643 toxic substance binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0097267 omega-hydroxylase P450 pathway;GO:0060242 contact inhibition;GO:0046685 response to arsenic-containing substance;GO:0060993 kidney morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41738-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05541-1", "uniprot_id": [ { "id": "CD8B_RAT", "url": "https://www.uniprot.org/uniprot/P05541", "type": "external" } ], "mass": 23400.0, "length": 208, "protein_name": "T-cell surface glycoprotein CD8 beta chain", "gene_name": "Cd8b", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD8 beta chain precursor", "refseq_ac": [ { "id": "NP_113727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113727", "type": "external" } ], "gene_names_uniprotkb": "Cd8b; Cd8b1", "gene_names_refseq": "Cd8b1; Cd8b", "protein_names_uniprotkb": "T-cell surface glycoprotein CD8 beta chain; CD8 antigen 37 kDa chain; OX-8 membrane antigen", "protein_names_refseq": "CD8 antigen 37 kDa chain; CD8 antigen beta-chain; CD8b molecule; OX-8 membrane antigen; T-cell surface glycoprotein CD8 beta chain precursor; T-cell surface glycoprotein CD8 beta chain", "tax_id": 10116, "disease": "", "pathway": " (rno:24931); (R-RNO-198933)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18089392;3092111", "class_list": "", "function": "CD8 positive T suppressor cells protect allogenic recipients from acute rejection in rats liver transplantation., [RefSeq, PubMed]; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05541-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27682-1", "uniprot_id": [ { "id": "7B2_RAT", "url": "https://www.uniprot.org/uniprot/P27682", "type": "external" } ], "mass": 23684.0, "length": 210, "protein_name": "Neuroendocrine protein 7B2", "gene_name": "Scg5", "organism": "Rat", "refseq_name": "neuroendocrine protein 7B2 precursor", "refseq_ac": [ { "id": "NP_037307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037307", "type": "external" } ], "gene_names_uniprotkb": "Scg5; Sgne1", "gene_names_refseq": "7B2; Scg5; Sgne1", "protein_names_uniprotkb": "Neuroendocrine protein 7B2; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein I", "protein_names_refseq": "Secretory granule neuroendocrine, protein 1 (7B2 protein); neuroendocrine protein 7B2 precursor; neuroendocrine protein 7B2; secretogranin V (7B2 protein); secretogranin-5; secretory granule endocrine protein I; secretory granule neuroendocrine protein 1", "tax_id": 10116, "disease": "pituitary-dependent Cushing's disease (Disease Ontology:DOID:3946)", "pathway": " (rno:25719)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11439082;16286464;1709861;21805245;22673903", "class_list": "", "function": "Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro., [UniProtKB, UniProtKB, UniProtKB]; Acute exposure of MIN6 cells transduced with rat 7B2 to high glucose increased endogenous 7B2 biosynthesis without affecting the levels of its mRNA., [RefSeq, PubMed]; Phosphorylation of 7B2 functionally inactivates this protein in a manner analogous to the phosphorylating inactivation of BiP, which impairs its ability to bind substrate, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0051082 unfolded protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0030141 secretory granule", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007218 neuropeptide signaling pathway;GO:0016486 peptide hormone processing;GO:0046883 regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P27682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39947-1", "uniprot_id": [ { "id": "CCNC_RAT", "url": "https://www.uniprot.org/uniprot/P39947", "type": "external" } ], "mass": 32514.0, "length": 278, "protein_name": "Cyclin-C", "gene_name": "Ccnc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccnc", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114839); (R-RNO-2173796); (R-RNO-9841922)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8336937", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0016592 mediator complex;GO:1990508 CKM complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0090209 negative regulation of triglyceride metabolic process;GO:0016567 protein ubiquitination;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P39947-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03070-1", "uniprot_id": [ { "id": "CHIO_RAT", "url": "https://www.uniprot.org/uniprot/Q03070", "type": "external" } ], "mass": 33837.0, "length": 295, "protein_name": "Beta-chimaerin", "gene_name": "Chn2", "organism": "Rat", "refseq_name": "beta-chimaerin", "refseq_ac": [ { "id": "NP_114473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114473", "type": "external" } ], "gene_names_uniprotkb": "Chn2; Arhgap3; Bch", "gene_names_refseq": "Chn2", "protein_names_uniprotkb": "Beta-chimaerin; Beta-chimerin; Rho GTPase-activating protein 3", "protein_names_refseq": "beta-chimaerin; beta-chimerin; chimerin (chimaerin) 2; rho GTPase-activating protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:84031); (R-RNO-9013149)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8440677", "class_list": "", "function": "GTPase-activating protein for p21-rac., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0001565 phorbol ester receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q03070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19327-1", "uniprot_id": [ { "id": "5HT1A_RAT", "url": "https://www.uniprot.org/uniprot/P19327", "type": "external" } ], "mass": 46429.0, "length": 422, "protein_name": "5-hydroxytryptamine receptor 1A", "gene_name": "Htr1a", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 1A", "refseq_ac": [ { "id": "NP_036717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036717", "type": "external" } ], "gene_names_uniprotkb": "Htr1a; 5ht1a", "gene_names_refseq": "5HT1A; Htr1a; RAT5HT1A", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A", "protein_names_refseq": "5-HT-1A; 5-HT1A; 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; 5-hydroxytryptamine receptor 1A; serotonin 1A receptor; serotonin 5-HT1A receptor; serotonin receptor 1A", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652); generalized anxiety disorder (Disease Ontology:DOID:14320); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); panic disorder (Disease Ontology:DOID:594); cocaine abuse (Disease Ontology:DOID:809); subacute delirium (Disease Ontology:DOID:8645)", "pathway": " (rno:24473); (R-RNO-390666)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18685031;2140514;2156831;2167416;37762636;37874340;38552745;38777263;38906512", "class_list": "", "function": "5-HT1A and 5-HT2A receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat., [RefSeq, PubMed]; Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain. Publication Status: Online-Only, [RefSeq, PubMed]; Effects of the suppression of 5-HT1A receptors in the left, right, or bilateral basolateral amygdala on memory consolidation in chronic stress in male rats., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:2140514, PubMed:2156831). Also functions as a receptor for various drugs and psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB expression in adult female rats., [RefSeq, PubMed]; Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0097305 response to alcohol;GO:0031117 positive regulation of microtubule depolymerization;GO:0007186 G protein-coupled receptor signaling pathway;GO:0035095 behavioral response to nicotine;GO:0046883 regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07882-1", "uniprot_id": [ { "id": "CEL_RAT", "url": "https://www.uniprot.org/uniprot/P07882", "type": "external" } ], "mass": 67040.0, "length": 612, "protein_name": "Bile salt-activated lipase", "gene_name": "Cel", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cel", "gene_names_refseq": "", "protein_names_uniprotkb": "Bile salt-activated lipase; 3.1.1.13; 3.1.1.3; 3.1.1.6; BAL; BSSL; Bile salt-stimulated lipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase", "protein_names_refseq": "", "tax_id": 10116, "disease": "maturity-onset diabetes of the young type 8 (Disease Ontology:DOID:0111105); lipomatosis (Disease Ontology:DOID:3153); pancreatitis (Disease Ontology:DOID:4989); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24254); (R-RNO-192456)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1999399;2069957;2211595;2688744;3593682", "class_list": "", "function": "Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:1999399, PubMed:2211595). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P14722", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0004771 sterol ester esterase activity;GO:0044877 protein-containing complex binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046514 ceramide catabolic process;GO:0030299 intestinal cholesterol absorption;GO:0030157 pancreatic juice secretion;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07882-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32038-1", "uniprot_id": [ { "id": "CFAD_RAT", "url": "https://www.uniprot.org/uniprot/P32038", "type": "external" } ], "mass": 28442.0, "length": 263, "protein_name": "Complement factor D", "gene_name": "Cfd", "organism": "Rat", "refseq_name": "complement factor D precursor", "refseq_ac": [ { "id": "NP_001071110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071110", "type": "external" } ], "gene_names_uniprotkb": "Cfd; Adn; Df", "gene_names_refseq": "Adn; Cfd; Df; EVE", "protein_names_uniprotkb": "Complement factor D; 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D", "protein_names_refseq": "C3 convertase activator; D component of complement (adipsin); adipsin; complement factor D precursor; endogenous vascular elastase; properdin factor D", "tax_id": 10116, "disease": "arthus reaction (Disease Ontology:DOID:1556); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54249); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1953671;8083356", "class_list": "", "function": "Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035886 vascular associated smooth muscle cell differentiation;GO:0007219 Notch signaling pathway;GO:0009617 response to bacterium;GO:0060041 retina development in camera-type eye;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P32038-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50230-1", "uniprot_id": [ { "id": "CCL4_RAT", "url": "https://www.uniprot.org/uniprot/P50230", "type": "external" } ], "mass": 10234.0, "length": 92, "protein_name": "C-C motif chemokine 4", "gene_name": "Ccl4", "organism": "Rat", "refseq_name": "C-C motif chemokine 4 precursor", "refseq_ac": [ { "id": "NP_446310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446310", "type": "external" } ], "gene_names_uniprotkb": "Ccl4; Mip1b; Scya4", "gene_names_refseq": "Ccl4; Mip1-b; Scya4", "protein_names_uniprotkb": "C-C motif chemokine 4; MIP-1-beta; Macrophage inflammatory protein 1-beta; Small-inducible cytokine A4", "protein_names_refseq": "C-C motif chemokine 4 precursor; C-C motif chemokine 4; MIP-1-beta; chemokine (C-C motif) ligand 4; macrophage inflammatory protein 1-beta; small-inducible cytokine A4", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); COVID-19 (Disease Ontology:DOID:0080600); dry eye syndrome (Disease Ontology:DOID:10140); viral pneumonia (Disease Ontology:DOID:10533); mastitis (Disease Ontology:DOID:10690); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); septic arthritis (Disease Ontology:DOID:813); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); visceral leishmaniasis (Disease Ontology:DOID:9146); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116637); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "17218081", "class_list": "", "function": "Monokine with inflammatory and chemokinetic properties., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1EC89", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031726 CCR1 chemokine receptor binding;GO:0031730 CCR5 chemokine receptor binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43143-1", "uniprot_id": [ { "id": "ACHA6_RAT", "url": "https://www.uniprot.org/uniprot/P43143", "type": "external" } ], "mass": 56947.0, "length": 493, "protein_name": "Neuronal acetylcholine receptor subunit alpha-6", "gene_name": "Chrna6", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-6 precursor", "refseq_ac": [ { "id": "NP_476532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476532", "type": "external" } ], "gene_names_uniprotkb": "Chrna6; Acra6", "gene_names_refseq": "Chrna6", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-6", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 6 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 6; neuronal acetylcholine receptor subunit alpha-6 precursor; neuronal acetylcholine receptor subunit alpha-6", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); alcohol use disorder (Disease Ontology:DOID:1574); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (rno:81721); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "18266937;21325521;24398291;28666811", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA6 forms pentameric channels with CHRNB2 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (By similarity). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (PubMed:21325521)., [UniProtKB, PubMed, UniProtKB]; Data indicate that the affinity of alpha-CTxLvIA selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors., [RefSeq, PubMed]; Study shows that alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty., [RefSeq, PubMed]; The concentration of alpha6- and beta3-containing neuronal nicotinic acetylcholine receptors (nAChRs) is higher in the optic nerve than in any other area of the rat brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20294-1", "uniprot_id": [ { "id": "CNTF_RAT", "url": "https://www.uniprot.org/uniprot/P20294", "type": "external" } ], "mass": 22854.0, "length": 200, "protein_name": "Ciliary neurotrophic factor", "gene_name": "Cntf", "organism": "Rat", "refseq_name": "ciliary neurotrophic factor", "refseq_ac": [ { "id": "NP_037298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037298", "type": "external" } ], "gene_names_uniprotkb": "Cntf", "gene_names_refseq": "Cntf", "protein_names_uniprotkb": "Ciliary neurotrophic factor; CNTF", "protein_names_refseq": "ciliary neurotrophic factor; ciliary neurotropic factor", "tax_id": 10116, "disease": "keratoconus (Disease Ontology:DOID:10126); retinitis pigmentosa (Disease Ontology:DOID:10584); Huntington's disease (Disease Ontology:DOID:12858); disease of mental health (Disease Ontology:DOID:150); glaucoma (Disease Ontology:DOID:1686); multiple sclerosis (Disease Ontology:DOID:2377); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25707); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "2342575;2594085;30504707;32313077;35925584;37408083;38334594", "class_list": "", "function": "CNTF activates Akt-Nrf2 signaling to protect myocardial cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation., [RefSeq, PubMed]; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy., [UniProtKB, UniProtKB]; Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways., [RefSeq, PubMed]; Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex. The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation (Probable). Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Can also signal via trans-signaling using soluble forms of CNTFR (By similarity). Seems to prevent the degeneration of motor axons after axotomy (PubMed:2342575)., [UniProtKB, PubMed, UniProtKB, PubMed]; Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum. Publication Status: Online-Only, [RefSeq, PubMed]; Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0032838 plasma membrane bounded cell projection cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0046668 regulation of retinal cell programmed cell death;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20294-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31721-1", "uniprot_id": [ { "id": "C1QB_RAT", "url": "https://www.uniprot.org/uniprot/P31721", "type": "external" } ], "mass": 26589.0, "length": 253, "protein_name": "Complement C1q subcomponent subunit B", "gene_name": "C1qb", "organism": "Rat", "refseq_name": "complement C1q subcomponent subunit B precursor", "refseq_ac": [ { "id": "NP_062135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062135", "type": "external" } ], "gene_names_uniprotkb": "C1qb", "gene_names_refseq": "Adia; C1qb", "protein_names_uniprotkb": "Complement C1q subcomponent subunit B", "protein_names_refseq": "adiponectin a; complement C1q subcomponent subunit B precursor; complement C1q subcomponent subunit B; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); severe acute respiratory syndrome (Disease Ontology:DOID:2945); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:29687); (R-RNO-173623); (R-RNO-977606)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "24939307;36464147;7594503;8464426", "class_list": "", "function": "Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]; Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion., [RefSeq, PubMed]; Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0051384 response to glucocorticoid;GO:0048839 inner ear development;GO:0098883 synapse pruning", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31721-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54258-1", "uniprot_id": [ { "id": "ATN1_RAT", "url": "https://www.uniprot.org/uniprot/P54258", "type": "external" } ], "mass": 124779.0, "length": 1183, "protein_name": "Atrophin-1", "gene_name": "Atn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atn1; Drpla", "gene_names_refseq": "", "protein_names_uniprotkb": "Atrophin-1; Dentatorubral-pallidoluysian atrophy protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29515)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19131340;22673903;8541849;9173996", "class_list": "", "function": "Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0016477 cell migration;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54258-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DWV1-1", "uniprot_id": [ { "id": "CAD20_RAT", "url": "https://www.uniprot.org/uniprot/Q5DWV1", "type": "external" } ], "mass": 89057.0, "length": 801, "protein_name": "Cadherin-20", "gene_name": "Cdh20", "organism": "Rat", "refseq_name": "cadherin-20 precursor", "refseq_ac": [ { "id": "NP_001012766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012766", "type": "external" } ], "gene_names_uniprotkb": "Cdh20; Cad20", "gene_names_refseq": "Cad20; Cdh20", "protein_names_uniprotkb": "Cadherin-20", "protein_names_refseq": "cadherin-20 precursor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:363948)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18801203;34240415", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expression of cad7 and cad20 demarcates the compartments, boundaries, progenitor domains, specific nuclei and specific neural circuits during mammalian brain development. Publication Status: Online-Only, [RefSeq, PubMed]; The distribution of Cdh20 mRNA demarcates somatotopic subregions and subpopulations of spiny projection neurons in the rat dorsolateral striatum., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5DWV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08485-1", "uniprot_id": [ { "id": "ACM4_RAT", "url": "https://www.uniprot.org/uniprot/P08485", "type": "external" } ], "mass": 52921.0, "length": 478, "protein_name": "Muscarinic acetylcholine receptor M4", "gene_name": "Chrm4", "organism": "Rat", "refseq_name": "muscarinic acetylcholine receptor M4", "refseq_ac": [ { "id": "NP_113735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113735", "type": "external" } ], "gene_names_uniprotkb": "Chrm4; Chrm-4", "gene_names_refseq": "Chrm4; M4", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M4", "protein_names_refseq": "cholinergic receptor, muscarin 4; muscarinic acetylcholine receptor M4", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25111); (R-RNO-390648); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22803069;29577888;3037705;31325565;32798726", "class_list": "", "function": "M1 and M4 muscarinic receptors are involved in shock-limiting and shock-activating processes, respectively, on the course of posthemorrhagic abnormalities in systemic and hepatic portal circulation., [RefSeq, PubMed]; Our data suggest that the changes in respiratory frequency and tidal volume produced by muscarinic cholinergic stimulation of the pedunculopontine tegmental nucleus is presumably mediated through a Gi-coupled M4 muscarinic receptors., [RefSeq, PubMed]; Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats., [RefSeq, PubMed]; Study showed that the muscarinic M4 receptor-preferring antagonist tropicamide consistently increased ERK phosphorylation in the striatum and medial prefrontal cortex., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P08485-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85971-1", "uniprot_id": [ { "id": "6PGL_RAT", "url": "https://www.uniprot.org/uniprot/P85971", "type": "external" } ], "mass": 27234.0, "length": 257, "protein_name": "6-phosphogluconolactonase", "gene_name": "Pgls", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pgls", "gene_names_refseq": "", "protein_names_uniprotkb": "6-phosphogluconolactonase; 3.1.1.31; 6PGL", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:290636); (R-RNO-71336)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19343716;22673903", "class_list": "", "function": "Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.31", "type": "external" }, { "id": "1.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.47", "type": "external" }, { "id": "1.1.1.363", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.363", "type": "external" } ], "go_molecular_function": "GO:0017057 6-phosphogluconolactonase activity;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P85971-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54708-1", "uniprot_id": [ { "id": "AT12A_RAT", "url": "https://www.uniprot.org/uniprot/P54708", "type": "external" } ], "mass": 114975.0, "length": 1036, "protein_name": "Potassium-transporting ATPase alpha chain 2", "gene_name": "Atp12a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp12a; Atp1al1", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium-transporting ATPase alpha chain 2; 7.2.2.13; 7.2.2.19; HK alpha 2; Non-gastric H(+)/K(+) ATPase subunit alpha; Non-gastric Na(+)/K(+) ATPase subunit alpha; Proton pump; Sodium pump", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); epilepsy (Disease Ontology:DOID:1826); hypokalemia (Disease Ontology:DOID:4500); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (R-RNO-936837)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10644526;1320029;14749213;38843836;7560093;9446555;9872395;9950762", "class_list": "", "function": "The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (PubMed:10644526, PubMed:7560093). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (By similarity). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0008900 P-type potassium:proton transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0055075 potassium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P54708-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49001-1", "uniprot_id": [ { "id": "BMP2_RAT", "url": "https://www.uniprot.org/uniprot/P49001", "type": "external" } ], "mass": 44383.0, "length": 393, "protein_name": "Bone morphogenetic protein 2", "gene_name": "Bmp2", "organism": "Rat", "refseq_name": "bone morphogenetic protein 2 precursor", "refseq_ac": [ { "id": "NP_058874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058874", "type": "external" } ], "gene_names_uniprotkb": "Bmp2; Bmp-2", "gene_names_refseq": "Bmp2", "protein_names_uniprotkb": "Bone morphogenetic protein 2; BMP-2A; BMP-2; Bone morphogenetic protein 2A", "protein_names_refseq": "BMP-2A; BMP-2; bone morphogenetic protein 2 precursor; bone morphogenetic protein 2A", "tax_id": 10116, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); Ullrich congenital muscular dystrophy (Disease Ontology:DOID:0050558); tooth agenesis (Disease Ontology:DOID:0050591); Bethlem myopathy (Disease Ontology:DOID:0050663); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); Ullrich congenital muscular dystrophy 1A (Disease Ontology:DOID:0060946); short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1 (Disease Ontology:DOID:0060989); Bethlem myopathy 1A (Disease Ontology:DOID:0061198); brachydactyly type A2 (Disease Ontology:DOID:0110965); hemochromatosis type 1 (Disease Ontology:DOID:0111029); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); Marfan syndrome (Disease Ontology:DOID:14323); osteoarthritis (Disease Ontology:DOID:8398); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:29373); (R-RNO-201451); (R-RNO-2129379)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "35981926;36421043;36613483;37331163;38063098", "class_list": "", "function": "Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (By similarity). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia., [RefSeq, PubMed]; Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-20 promotes cartilage repair in knee osteoarthritis rats via BMP2/Smad1 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Sustained release of BMP-2 using self-assembled layer-by-layer film-coated implants enhances bone regeneration over burst release., [RefSeq, PubMed]; The impact of IGF-1 on alveolar bone remodeling and BMP-2 expression in orthodontic tooth movement in diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031982 vesicle", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:1901331 positive regulation of odontoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49001-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49002-1", "uniprot_id": [ { "id": "BMP3_RAT", "url": "https://www.uniprot.org/uniprot/P49002", "type": "external" } ], "mass": 52675.0, "length": 468, "protein_name": "Bone morphogenetic protein 3", "gene_name": "Bmp3", "organism": "Rat", "refseq_name": "bone morphogenetic protein 3 precursor", "refseq_ac": [ { "id": "NP_058801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058801", "type": "external" } ], "gene_names_uniprotkb": "Bmp3; Bmp-3", "gene_names_refseq": "Bmp3; PBMP3", "protein_names_uniprotkb": "Bone morphogenetic protein 3; BMP-3", "protein_names_refseq": "BMP-3; bone morphogenetic protein 3 precursor", "tax_id": 10116, "disease": "Ullrich congenital muscular dystrophy 1B (Disease Ontology:DOID:0060942); Bethlem myopathy 1A (Disease Ontology:DOID:0061198); Bethlem myopathy 1B (Disease Ontology:DOID:0061199); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25667)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12689682;21415150;27130896;32568738;7880444;8605043", "class_list": "", "function": "Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis., [RefSeq, PubMed]; Data indicate that bone morphogenetic protein-3 (BMP3) is widely expressed throughout the adult central nervous system, and its abundant expression in the adult brain strongly supports the idea that BMP3 plays important roles in the adult brain., [RefSeq, PubMed]; Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis., [RefSeq, PubMed]; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031982 vesicle;GO:0005576 extracellular region", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0001649 osteoblast differentiation;GO:0051216 cartilage development;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49002-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23593-1", "uniprot_id": [ { "id": "APOD_RAT", "url": "https://www.uniprot.org/uniprot/P23593", "type": "external" } ], "mass": 21635.0, "length": 189, "protein_name": "Apolipoprotein D", "gene_name": "Apod", "organism": "Rat", "refseq_name": "apolipoprotein D precursor", "refseq_ac": [ { "id": "NP_036909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036909", "type": "external" } ], "gene_names_uniprotkb": "Apod", "gene_names_refseq": "AOPDGN; Apod", "protein_names_uniprotkb": "Apolipoprotein D; Apo-D; ApoD", "protein_names_refseq": "apo-D; apolipoprotein D precursor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); status epilepticus (Disease Ontology:DOID:1824); vasculogenic impotence (Disease Ontology:DOID:4762); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25239); (R-RNO-804914)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1695148;2090718;24082102;27566528", "class_list": "", "function": "APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ApoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity., [RefSeq, PubMed]; Collectively, results of this study suggest that Apod is a novel regulatory gene in the male reproductive system, especially in penises of rats fed a high-cholesterol diet, and that expression of Apod is regulated at the posttranscriptional level by target microRNAs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0007420 brain development;GO:0006006 glucose metabolic process;GO:0051895 negative regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23593-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05540-1", "uniprot_id": [ { "id": "CD4_RAT", "url": "https://www.uniprot.org/uniprot/P05540", "type": "external" } ], "mass": 51438.0, "length": 457, "protein_name": "T-cell surface glycoprotein CD4", "gene_name": "Cd4", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD4 precursor", "refseq_ac": [ { "id": "NP_036837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036837", "type": "external" } ], "gene_names_uniprotkb": "Cd4", "gene_names_refseq": "Cd4; W3/25; p55", "protein_names_uniprotkb": "T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; W3/25 antigen", "protein_names_refseq": "CD4 antigen; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 precursor; T-cell surface glycoprotein CD4; W3/25 antigen", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); immunodeficiency 79 (Disease Ontology:DOID:0112277); sialadenitis (Disease Ontology:DOID:10303); severe acute respiratory syndrome (Disease Ontology:DOID:2945); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); amphetamine abuse (Disease Ontology:DOID:670); septic arthritis (Disease Ontology:DOID:813)", "pathway": " (rno:24932); (R-RNO-1462054); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-389948); (R-RNO-449836); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "10207177;2113054;26467126;29393594;29772575;3104900;34944007;8429003;8493535", "class_list": "", "function": "Adoptive transfusion of CD4+CD25+ Regulatory T Cells into Experimental Autoimmune Neuritis model rats has significant therapeutic effects., [RefSeq, PubMed]; C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance. Publication Status: Online-Only, [RefSeq, PubMed]; Increased C4d deposition may be amenable to identify early myocardial infarction after cardiac arrest., [RefSeq, PubMed]; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 8, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 19, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0015026 coreceptor activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0045471 response to ethanol;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P05540-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100011001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06238-1", "uniprot_id": [ { "id": "A2MG_RAT", "url": "https://www.uniprot.org/uniprot/P06238", "type": "external" } ], "mass": 163785.0, "length": 1472, "protein_name": "Alpha-2-macroglobulin", "gene_name": "A2m", "organism": "Rat", "refseq_name": "alpha-2-macroglobulin precursor", "refseq_ac": [ { "id": "NP_036620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036620", "type": "external" } ], "gene_names_uniprotkb": "A2m; A2m1", "gene_names_refseq": "A2MAC1; A2m1; A2maa; A2mb; A2m; Mam", "protein_names_uniprotkb": "Alpha-2-macroglobulin; Alpha-2-M", "protein_names_refseq": "alpha-2-M; alpha-2-macroglobulin precursor; alpha-2-macroglobulin-P", "tax_id": 10116, "disease": "hepatocellular adenoma (Disease Ontology:DOID:0050868); COVID-19 (Disease Ontology:DOID:0080600); trypanosomiasis (Disease Ontology:DOID:10113); osteonecrosis (Disease Ontology:DOID:10159); Alzheimer's disease (Disease Ontology:DOID:10652); membranous glomerulonephritis (Disease Ontology:DOID:10976); heart disease (Disease Ontology:DOID:114); nephrotic syndrome (Disease Ontology:DOID:1184); background diabetic retinopathy (Disease Ontology:DOID:13208); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); obstructive lung disease (Disease Ontology:DOID:2320); multiple sclerosis (Disease Ontology:DOID:2377); cerebral infarction (Disease Ontology:DOID:3526); hemolytic anemia (Disease Ontology:DOID:583); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283)", "pathway": " (rno:24153); (R-RNO-114608); (R-RNO-1474228); (R-RNO-8963896); (R-RNO-9855719)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "1725450;21454685;2414291;2432068;2466233;26895739;27301375;36894970", "class_list": "", "function": "Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Elevated serum level correlated to glucocorticoid treatment and may represent a form of reparative response to glucocorticoid-associated damage of bone, [RefSeq, PubMed]; Gastric contents-induced acute lung injury elicits a liver acute phase response characterized by increased mRNA expression of alpha 2 macroglobulin and alpha1-antitrypsin. Publication Status: Online-Only, [RefSeq, PubMed]; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZY3", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1990402 embryonic liver development;GO:0001869 negative regulation of complement activation, lectin pathway;GO:0007584 response to nutrient;GO:0048863 stem cell differentiation;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06238-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07171-1", "uniprot_id": [ { "id": "CALB1_RAT", "url": "https://www.uniprot.org/uniprot/P07171", "type": "external" } ], "mass": 29994.0, "length": 261, "protein_name": "Calbindin", "gene_name": "Calb1", "organism": "Rat", "refseq_name": "calbindin", "refseq_ac": [ { "id": "NP_114190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114190", "type": "external" } ], "gene_names_uniprotkb": "Calb1", "gene_names_refseq": "CaBP28K; Calb1", "protein_names_uniprotkb": "Calbindin; Calbindin D28; D-28K; Spot 35 protein; Vitamin D-dependent calcium-binding protein, avian-type", "protein_names_refseq": "D-28K; calbindin 1, 28 kD; calbindin D28; calbindin; cerebellar Ca-binding protein, spot 35 protein; vitamin D-dependent calcium-binding protein, avian-type", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); alcohol use disorder (Disease Ontology:DOID:1574); bilirubin metabolic disorder (Disease Ontology:DOID:2741)", "pathway": " (rno:83839)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16799559;1988053;26975894;2792772;2843757;3031218;3049577;33040447;3755822", "class_list": "", "function": "Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Calbindin D-28K does not appear to associate with any particular neuronal phenotype in the spinal dorsal horn, which may reflect that fact that most morphological types can be excitatory or inhibitory Its expression and distribution is unaffected by chronic constriction injury and increased excitatory synaptic drive to Cal+ neurons is unlikely to play a role in chronic constriction injury-induced central sensitization, [RefSeq, PubMed]; Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding;GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042359 vitamin D metabolic process;GO:0007611 learning or memory;GO:0007626 locomotory behavior;GO:0007614 short-term memory;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07171-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07448-1", "uniprot_id": [ { "id": "DFTS_RAT", "url": "https://www.uniprot.org/uniprot/P07448", "type": "external" } ], "mass": 2165.0, "length": 20, "protein_name": "Dentinal fluid transport-stimulating peptide", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Dentinal fluid transport-stimulating peptide; DFT-stimulating peptide", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "3815601;5297832", "class_list": "", "function": "This peptide stimulates the transport of dentinal fluid, which is important for the prevention of dental caries., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P07448-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07725-1", "uniprot_id": [ { "id": "CD8A_RAT", "url": "https://www.uniprot.org/uniprot/P07725", "type": "external" } ], "mass": 26196.0, "length": 236, "protein_name": "T-cell surface glycoprotein CD8 alpha chain", "gene_name": "Cd8a", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD8 alpha chain precursor", "refseq_ac": [ { "id": "NP_113726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113726", "type": "external" } ], "gene_names_uniprotkb": "Cd8a", "gene_names_refseq": "Cd8a", "protein_names_uniprotkb": "T-cell surface glycoprotein CD8 alpha chain; CD8 antigen 32 kDa chain; OX-8 membrane antigen", "protein_names_refseq": "CD8 antigen 32 kDa chain; CD8 antigen, alpha-chain; CD8a molecule; OX-8 membrane antigen; T-cell surface glycoprotein CD8 alpha chain precursor; T-cell surface glycoprotein CD8 alpha chain", "tax_id": 10116, "disease": "erythema multiforme (Disease Ontology:DOID:0050185); immunodeficiency 116 (Disease Ontology:DOID:0061082); COVID-19 (Disease Ontology:DOID:0080600); stomach cancer (Disease Ontology:DOID:10534); brain infarction (Disease Ontology:DOID:3454); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (rno:24930); (R-RNO-198933)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1908233;31681288;3932064", "class_list": "", "function": "Alloactivation of Naive CD4(+)CD8(-)CD25(+)T Regulatory Cells: Expression of CD8alpha Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction. Publication Status: Online-Only, [RefSeq, PubMed]; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 5, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0044853 plasma membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07824-1", "uniprot_id": [ { "id": "ARGI1_RAT", "url": "https://www.uniprot.org/uniprot/P07824", "type": "external" } ], "mass": 34973.0, "length": 323, "protein_name": "Arginase-1", "gene_name": "Arg1", "organism": "Rat", "refseq_name": "arginase-1", "refseq_ac": [ { "id": "NP_058830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058830", "type": "external" } ], "gene_names_uniprotkb": "Arg1", "gene_names_refseq": "Arg1", "protein_names_uniprotkb": "Arginase-1; 3.5.3.1; Liver-type arginase; Type I arginase", "protein_names_refseq": "AI type I arginase; arginase, liver; arginase-1; liver-type arginase; type I arginase", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); achromatopsia 2 (Disease Ontology:DOID:0110007); silicosis (Disease Ontology:DOID:10325); hypertension (Disease Ontology:DOID:10763); uveitis (Disease Ontology:DOID:13141); color blindness (Disease Ontology:DOID:13399); cholestasis (Disease Ontology:DOID:13580); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); liver disease (Disease Ontology:DOID:409); ureteral obstruction (Disease Ontology:DOID:5199); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperargininemia (Disease Ontology:DOID:9278)", "pathway": " (rno:29221); (R-RNO-6798695); (R-RNO-70635)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10542097;11883902;12820884;15315440;16266687;21454685;22673903;2892837;3571256;37042199;8849731;9265637", "class_list": "", "function": "Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis., [RefSeq, PubMed]; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (By similarity). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific. In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity., [UniProtKB, UniProtKB, UniProtKB]; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK93", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.5.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.-", "type": "external" }, { "id": "3.5.3.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.17", "type": "external" }, { "id": "3.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.7", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0004053 arginase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001889 liver development;GO:0010043 response to zinc ion;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0071377 cellular response to glucagon stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07824-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08082-1", "uniprot_id": [ { "id": "CLCB_RAT", "url": "https://www.uniprot.org/uniprot/P08082", "type": "external" } ], "mass": 25117.0, "length": 229, "protein_name": "Clathrin light chain B", "gene_name": "Cltb", "organism": "Rat", "refseq_name": "clathrin light chain B isoform 1", "refseq_ac": [ { "id": "NP_446287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446287", "type": "external" } ], "gene_names_uniprotkb": "Cltb", "gene_names_refseq": "Cltb", "protein_names_uniprotkb": "Clathrin light chain B; Lcb", "protein_names_refseq": "clathrin light chain B isoform 1; clathrin, light chain (Lcb); clathrin, light polypeptide (Lcb); lcb", "tax_id": 10116, "disease": "", "pathway": " (rno:116561); (R-RNO-190873); (R-RNO-196025); (R-RNO-432720); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "3563513", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005198 structural molecule activity;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0007269 neurotransmitter secretion;GO:0048488 synaptic vesicle endocytosis;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08082-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08483-1", "uniprot_id": [ { "id": "ACM3_RAT", "url": "https://www.uniprot.org/uniprot/P08483", "type": "external" } ], "mass": 66066.0, "length": 589, "protein_name": "Muscarinic acetylcholine receptor M3", "gene_name": "Chrm3", "organism": "Rat", "refseq_name": "muscarinic acetylcholine receptor M3", "refseq_ac": [ { "id": "NP_036659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036659", "type": "external" } ], "gene_names_uniprotkb": "Chrm3; Chrm-3", "gene_names_refseq": "Chrm3", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M3", "protein_names_refseq": "cholinergic receptor, muscarinic 3, cardiac; muscarinic acetylcholine receptor M3", "tax_id": 10116, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); small cell carcinoma (Disease Ontology:DOID:0050685); megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); prune belly syndrome (Disease Ontology:DOID:0060889); Leber congenital amaurosis 8 (Disease Ontology:DOID:0110079); retinitis pigmentosa 12 (Disease Ontology:DOID:0110358); pigmented paravenous chorioretinal atrophy (Disease Ontology:DOID:0111541); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bladder disease (Disease Ontology:DOID:365); pulmonary fibrosis (Disease Ontology:DOID:3770); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:24260); (R-RNO-390648); (R-RNO-416476)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "1527051;1657592;20461055;22358844;2380182;26626425;27858307;30354759;3037705;3120722;32534071;3272174;36445617;9972520", "class_list": "", "function": "Data suggest that, in atrial myocardium (or isolated cardiomyocytes), activation of muscarinic receptors M3 (Chrm3) leads to shortening of action potentials via suppression of L-type calcium channels; the major potassium channels are not affected, but inwardly rectifying potassium channels are suppressed., [RefSeq, PubMed]; Eliminating muscarinic cholinergic 3 receptor (M3R) from Dahl salt sensitive (DSS) rats Improves diastolic dysfunction., [RefSeq, PubMed]; Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs., [RefSeq, PubMed]; M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product. Publication Status: Online-Only, [RefSeq, PubMed]; M3 but not M4 muscarinic receptors in the rostromedial tegmental nucleus are involved in the acquisition of morphine-induced conditioned place preference., [RefSeq, PubMed]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWK9", "ec_number_list": [], "go_molecular_function": "GO:0016907 G protein-coupled acetylcholine receptor activity;GO:0042166 acetylcholine binding;GO:0031789 G protein-coupled acetylcholine receptor binding;GO:0050997 quaternary ammonium group binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0032279 asymmetric synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P08483-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08649-1", "uniprot_id": [ { "id": "CO4_RAT", "url": "https://www.uniprot.org/uniprot/P08649", "type": "external" } ], "mass": 192163.0, "length": 1737, "protein_name": "Complement C4", "gene_name": "C4a; C4b; C4", "organism": "Rat", "refseq_name": "complement C4 precursor", "refseq_ac": [ { "id": "NP_113692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113692", "type": "external" } ], "gene_names_uniprotkb": "C4a; C4b; C4; C4a; C4b", "gene_names_refseq": "C4-1; C4a; C4b; C4", "protein_names_uniprotkb": "Complement C4", "protein_names_refseq": "complement C4 precursor; complement C4-like; complement C4; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group)", "tax_id": 10116, "disease": "complement component 4a deficiency (Disease Ontology:DOID:0060297); complement component 4b deficiency (Disease Ontology:DOID:0060298); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); autistic disorder (Disease Ontology:DOID:12849); renal cell carcinoma (Disease Ontology:DOID:4450); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:24233); (rno:406161); (R-RNO-166663); (R-RNO-174577); (R-RNO-381426); (R-RNO-8957275); (R-RNO-977606)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "12136338;21454685;23613499;26219954;29393594;3262196;8805663", "class_list": "", "function": "Non-enzymatic component of C3 and C5 convertases. Generated following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway), it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. It then recruits the serine protease complement C2b to form the C3 and C5 convertases, which cleave and activate C3 and C5, respectively, the next components of the complement pathways. Complement C4b-A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while complement C4b-B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our study provides the first evidence that sustained selective EPAC activation leads to an increase in TRPC3 and C4 protein expression and induces a proarrhythmic SOCE-like activity in adult rat ventricular cardiomyocytes, [RefSeq, PubMed]; Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The expression of the complement component C3f and complement component 4A have potential for use in post-transplant diagnosis of rejection., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q62895;Q8R403", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0030246 carbohydrate binding;GO:0003823 antigen binding;GO:0001849 complement component C1q complex binding;GO:0001848 complement binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006954 inflammatory response;GO:0001867 complement activation, lectin pathway;GO:0016064 immunoglobulin mediated immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08649-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08650-1", "uniprot_id": [ { "id": "CO5_RAT", "url": "https://www.uniprot.org/uniprot/P08650", "type": "external" } ], "mass": 189081.0, "length": 1681, "protein_name": "Complement C5", "gene_name": "C5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C5", "gene_names_refseq": "", "protein_names_uniprotkb": "Complement C5; Complement C5 alpha' chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); adult respiratory distress syndrome (Disease Ontology:DOID:11394); factor VIII deficiency (Disease Ontology:DOID:12134); neutropenia (Disease Ontology:DOID:1227); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); complement component 5 deficiency (Disease Ontology:DOID:8158)", "pathway": " (rno:362119); (R-RNO-166665); (R-RNO-174577); (R-RNO-375276); (R-RNO-418594); (R-RNO-977606)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "7987212;9116048", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. Complement C5b is generated following cleavage by C5 convertase and initiates formation of the MAC complex: C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. During MAC complex assembly, the C5b6 subcomplex, composed of complement C5b and C6, associates with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediator of local inflammatory process released following cleavage by C5 convertase. Acts by binding to its receptor (C5AR1 or C5AR2), activating G protein-coupled receptor signaling and inducing a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated downstream of classical, alternative, lectin and GZMK complement pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A096P6L9;Q63078", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0008009 chemokine activity;GO:0031714 C5a anaphylatoxin chemotactic receptor binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0055085 transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0010575 positive regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08650-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09057-1", "uniprot_id": [ { "id": "DCOR_RAT", "url": "https://www.uniprot.org/uniprot/P09057", "type": "external" } ], "mass": 51047.0, "length": 461, "protein_name": "Ornithine decarboxylase", "gene_name": "Odc1", "organism": "Rat", "refseq_name": "ornithine decarboxylase", "refseq_ac": [ { "id": "NP_001289012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289012", "type": "external" } ], "gene_names_uniprotkb": "Odc1; Odc", "gene_names_refseq": "Odc1; Odc", "protein_names_uniprotkb": "Ornithine decarboxylase; 4.1.1.17; ODC", "protein_names_refseq": "Ornitine decarboxylase; ornithine decarboxylase", "tax_id": 10116, "disease": "atrichia with papular lesions (Disease Ontology:DOID:0060689); colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); colon carcinoma (Disease Ontology:DOID:1520); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); varicose veins (Disease Ontology:DOID:799); nasopharynx carcinoma (Disease Ontology:DOID:9261); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:24609); (R-RNO-350562); (R-RNO-351202)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2006916;22230191;24464033;2722815;28986097;3419906;3443298", "class_list": "", "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, UniProtKB]; The modulation of ODC activity by AMPK represents a mechanism that may contribute to control cell growth processes., [RefSeq, PubMed]; The results indicated that overexpression of ODC gene promotes the proliferation while suppressing apoptosis of fibroblast-like synoviocytes in rats with rheumatoid arthritis., [RefSeq, PubMed]; These results suggest that IPC upregulates the Ornithine decarboxylase/polyamine system and mediates preconditioning cardioprotection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042803 protein homodimerization activity;GO:0042978 ornithine decarboxylase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0001822 kidney development;GO:0009615 response to virus;GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09057-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5I0-1", "uniprot_id": [ { "id": "CDNF_RAT", "url": "https://www.uniprot.org/uniprot/P0C5I0", "type": "external" } ], "mass": 21361.0, "length": 187, "protein_name": "Cerebral dopamine neurotrophic factor", "gene_name": "Cdnf", "organism": "Rat", "refseq_name": "cerebral dopamine neurotrophic factor precursor", "refseq_ac": [ { "id": "NP_001032632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032632", "type": "external" } ], "gene_names_uniprotkb": "Cdnf; Armetl1", "gene_names_refseq": "Armetl1; Cdnf", "protein_names_uniprotkb": "Cerebral dopamine neurotrophic factor; ARMET-like protein 1; Arginine-rich protein mutated in early stage tumors-like 1; Conserved dopamine neurotrophic factor", "protein_names_refseq": "ARMET-like protein 1; arginine-rich protein mutated in early stage tumors-like 1; arginine-rich, mutated in early stage tumors-like 1; cerebral dopamine neurotrophic factor precursor; conserved dopamine neurotrophic factor", "tax_id": 10116, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:361276)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17611540;21235575;23624196;26271594;28553166;33154393", "class_list": "", "function": "Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviated cell damage and proinflammatory cytokine secretion, which may represent a promising strategy for neuroprotection in the central nervous system (CNS)., [RefSeq, PubMed]; Disruption of the helix-1 domain of cerebral dopamine neurotrophic factor significantly reduces its secretion in endoplasmic reticulum., [RefSeq, PubMed]; In all, these findings suggest that helix-7 in the C-terminal is important for CDNF secretion, which maybe potential affect CDNF function in ER stress., [RefSeq, PubMed]; Results demonstrated that CDNF overexpression in the brain could attenuate the METH-induced dopamine and tyrosine hydroxylase loss in the striatum but could not lower METH-induced hyperthermia. Publication Status: Online-Only, [RefSeq, PubMed]; Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005576 extracellular region", "go_biological_process": "GO:0031175 neuron projection development;GO:0032502 developmental process;GO:0071542 dopaminergic neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0C5I0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11348-1", "uniprot_id": [ { "id": "DHPR_RAT", "url": "https://www.uniprot.org/uniprot/P11348", "type": "external" } ], "mass": 25552.0, "length": 241, "protein_name": "Dihydropteridine reductase", "gene_name": "Qdpr", "organism": "Rat", "refseq_name": "dihydropteridine reductase", "refseq_ac": [ { "id": "NP_071785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071785", "type": "external" } ], "gene_names_uniprotkb": "Qdpr; Dhpr", "gene_names_refseq": "Qdpr", "protein_names_uniprotkb": "Dihydropteridine reductase; 1.5.1.34; HDHPR; Quinoid dihydropteridine reductase", "protein_names_refseq": "HDHPR; dihydropteridine reductase", "tax_id": 10116, "disease": "BH4-deficient hyperphenylalaninemia C (Disease Ontology:DOID:0081130); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:64192); (R-RNO-8964208)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1631094;1898002;19743417;20643204;22673903;3566737;3680258;8304094", "class_list": "", "function": "Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data show that intrauterine growth restriction increases serotonin biosynthesis in the brainstem, which is accompanied by an increase in dihydropteridine reductase activity that may be a compensatory mechanism to maintain sufficient tetrahydrobiopterin., [RefSeq, PubMed]; Results suggest that the deficiency in tetrahydrobiopterin regeneration produced by diminished dihydrobiopterin reductase expression is involved in vascular disorders in hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.34", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070402 NADPH binding;GO:0004155 6,7-dihydropteridine reductase activity;GO:0070404 NADH binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001889 liver development;GO:0010288 response to lead ion;GO:0071466 cellular response to xenobiotic stimulus;GO:0010044 response to aluminum ion;GO:0006559 L-phenylalanine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11348-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11608-1", "uniprot_id": [ { "id": "ATP8_RAT", "url": "https://www.uniprot.org/uniprot/P11608", "type": "external" } ], "mass": 7630.0, "length": 67, "protein_name": "ATP synthase F(0) complex subunit 8", "gene_name": "Mt-atp8", "organism": "Rat", "refseq_name": "ATP synthase F0 subunit 8", "refseq_ac": [ { "id": "YP_665633", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665633", "type": "external" } ], "gene_names_uniprotkb": "Mt-atp8; Atp8; Atpase8; Mtatp8", "gene_names_refseq": "ATP8", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit 8; A6L; Chargerin II; F-ATPase subunit 8", "protein_names_refseq": "ATP synthase F0 subunit 8", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (rno:26196); (R-RNO-163210); (R-RNO-5419276); (R-RNO-8949613)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17575325;24185961;2504926;3360805;8529844", "class_list": "", "function": "Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q35736", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0055093 response to hyperoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11608-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12075-1", "uniprot_id": [ { "id": "COX5B_RAT", "url": "https://www.uniprot.org/uniprot/P12075", "type": "external" } ], "mass": 13915.0, "length": 129, "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "Cox5b", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 5B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_446038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446038", "type": "external" } ], "gene_names_uniprotkb": "Cox5b", "gene_names_refseq": "Cox5b", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase polypeptide Vb; Cytochrome c oxidase subunit VIA*", "protein_names_refseq": "cytochrome c oxidase polypeptide Vb; cytochrome c oxidase subunit 5B, mitochondrial precursor; cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase subunit VIA*; cytochrome c oxidase subunit Vb", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (rno:94194); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564); (R-RNO-9837999)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "18408135;2549512;28246552;7601105;8206867", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]; Decreased Tissue COX5B Expression is associated with Mitochondrial Dysfunction during Sepsis-Induced Kidney Injury, [RefSeq, PubMed]; Report loss of Cox5b subunits in ischemia-reperfusion injury and exacerbation of subunit loss by PKC-epsilon inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0097066 response to thyroid hormone;GO:0043434 response to peptide hormone;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P12075-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12389-1", "uniprot_id": [ { "id": "ACHA2_RAT", "url": "https://www.uniprot.org/uniprot/P12389", "type": "external" } ], "mass": 58611.0, "length": 511, "protein_name": "Neuronal acetylcholine receptor subunit alpha-2", "gene_name": "Chrna2", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_596911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596911", "type": "external" } ], "gene_names_uniprotkb": "Chrna2; Acra2", "gene_names_refseq": "ACHR; Chrna2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-2", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2 precursor; neuronal acetylcholine receptor subunit alpha-2; nicotinic acetylcholine receptor", "tax_id": 10116, "disease": "autosomal dominant nocturnal frontal lobe epilepsy 4 (Disease Ontology:DOID:0060685); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (rno:170945); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15026122;19385992;2832952;7678806", "class_list": "", "function": "At least two different affinity sites for acetylcholine. Sensitivity to block of alpha4beta2 channels by dihydro-beta-erythroidine was higher than that for alpha2beta2. Current-voltage for alpha2beta2 more strongly rectified than for alpha4beta2., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence., [UniProtKB, UniProtKB]; Results suggest that nicotine alters the normal operation of hippocampal circuits by gating inhibitory circuits through activating a non-desensitizing alpha2 nAChR subtype on a distinct population of interneurons., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08952;Q53YK3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1901363 heterocyclic compound binding;GO:0050997 quaternary ammonium group binding;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0098828 modulation of inhibitory postsynaptic potential;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12389-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12391-1", "uniprot_id": [ { "id": "ACHB3_RAT", "url": "https://www.uniprot.org/uniprot/P12391", "type": "external" } ], "mass": 53261.0, "length": 464, "protein_name": "Neuronal acetylcholine receptor subunit beta-3", "gene_name": "Chrnb3", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit beta-3 precursor", "refseq_ac": [ { "id": "NP_598281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598281", "type": "external" } ], "gene_names_uniprotkb": "Chrnb3; Acrb3", "gene_names_refseq": "Chrnb3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-3", "protein_names_refseq": "cholinergic receptor, nicotinic beta 3; cholinergic receptor, nicotinic, beta 3 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 3; neuronal acetylcholine receptor subunit beta-3 precursor; neuronal acetylcholine receptor subunit beta-3", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); bipolar disorder (Disease Ontology:DOID:3312); congenital myasthenic syndrome (Disease Ontology:DOID:3635); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:171131); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18266937;2703489", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4. Seems to play a role in nicotine addiction., [UniProtKB, UniProtKB]; The concentration of beta3- and alpha6- containing neuronal nicotinic acetylcholine receptors (nAChRs) is higher in the optic nerve than in any other area of the rat brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P12391-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12711-1", "uniprot_id": [ { "id": "ADHX_RAT", "url": "https://www.uniprot.org/uniprot/P12711", "type": "external" } ], "mass": 39576.0, "length": 374, "protein_name": "Alcohol dehydrogenase class-3", "gene_name": "Adh4; Adh5", "organism": "Rat", "refseq_name": "alcohol dehydrogenase class-3", "refseq_ac": [ { "id": "NP_001119592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119592", "type": "external" } ], "gene_names_uniprotkb": "Adh4; Adh5; Adh-2; Adh2; Adh5", "gene_names_refseq": "Adh5", "protein_names_uniprotkb": "Alcohol dehydrogenase class-3; 1.1.1.-; 1.1.1.1; 1.1.1.284; ADH-B2; Alcohol dehydrogenase 2; Alcohol dehydrogenase 5; Alcohol dehydrogenase B2; Alcohol dehydrogenase class-III; FALDH; FDH; GSH-FDH; Glutathione-dependent formaldehyde dehydrogenase; S-(hydroxymethyl)glutathione dehydrogenase", "protein_names_refseq": "ADH-B2; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase; alcohol dehydrogenase 2; alcohol dehydrogenase B2; alcohol dehydrogenase class-3; alcohol dehydrogenase class-III; class III alcohol dehydrogenase, chi subunit; glutathione-dependent formaldehyde dehydrogenase", "tax_id": 10116, "disease": "AMED syndrome (Disease Ontology:DOID:0080952); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:100145871); (R-RNO-71384)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1888714;23159888;24654711;26746429;29393594;3278908;3653405", "class_list": "", "function": "ADH5, while readily expressed at the mRNA level, does not behave similarly to other mammalian ADHs investigated., [RefSeq, PubMed]; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione., [RefSeq, PubMed]; We have defined a novel role of GSNOR in neurite development and provide molecular insights into the control of neurite growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIF8", "ec_number_list": [ { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0005504 fatty acid binding;GO:0008270 zinc ion binding;GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0003016 respiratory system process;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12711-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13941-1", "uniprot_id": [ { "id": "CO3A1_RAT", "url": "https://www.uniprot.org/uniprot/P13941", "type": "external" } ], "mass": 138936.0, "length": 1463, "protein_name": "Collagen alpha-1(III) chain", "gene_name": "Col3a1", "organism": "Rat", "refseq_name": "collagen alpha-1(III) chain precursor", "refseq_ac": [ { "id": "NP_114474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114474", "type": "external" } ], "gene_names_uniprotkb": "Col3a1", "gene_names_refseq": "Col3a1", "protein_names_uniprotkb": "Collagen alpha-1(III) chain", "protein_names_refseq": "collagen alpha-1(III) chain precursor; collagen alpha-1(III) chain; collagen, type III, alpha 1; procollagen, type III, alpha 1", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); renal fibrosis (Disease Ontology:DOID:0050855); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); bladder neck obstruction (Disease Ontology:DOID:13948); vascular type Ehlers-Danlos syndrome (Disease Ontology:DOID:14756); Ehlers-Danlos syndrome hypermobility type (Disease Ontology:DOID:14757); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84032); (R-RNO-1442490); (R-RNO-1566977); (R-RNO-1650814); (R-RNO-186797); (R-RNO-2022090); (R-RNO-216083); (R-RNO-3000171); (R-RNO-3000178); (R-RNO-419037); (R-RNO-8874081); (R-RNO-8948216)", "pathway_count": 12, "publication_count": 4, "publication_id_list": "2456904;29286102;32328952;8286415", "class_list": "", "function": "Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12 (By similarity)., [UniProtKB]; Expression of Metalloproteinases and Type I and III Collagens during Healing of Excisional Skin Wound on the Abdomen and Back in Rats., [RefSeq, PubMed]; The activation of Pin1 promoted cardiac extracellular matrix deposition and oxidative stress damage by regulating the phosphorylation of the MEK1/2ERK1/2 signaling pathway and the expression of alphaSMA., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70604;Q5PQT6", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0046332 SMAD binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0005586 collagen type III trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007229 integrin-mediated signaling pathway;GO:0007507 heart development;GO:0030198 extracellular matrix organization;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13941-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14056-1", "uniprot_id": [ { "id": "ARAF_RAT", "url": "https://www.uniprot.org/uniprot/P14056", "type": "external" } ], "mass": 67551.0, "length": 604, "protein_name": "Serine/threonine-protein kinase A-Raf", "gene_name": "Araf", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase A-Raf isoform 1", "refseq_ac": [ { "id": "NP_071977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071977", "type": "external" } ], "gene_names_uniprotkb": "Araf; A-raf; Araf1", "gene_names_refseq": "Araf1; Araf", "protein_names_uniprotkb": "Serine/threonine-protein kinase A-Raf; 2.7.11.1; Proto-oncogene A-Raf-1; Proto-oncogene A-Raf", "protein_names_refseq": "A-Raf proto-oncogene serine/threonine-protein kinase; Raf related protein; Ras-binding protein; proto-oncogene A-Raf-1; proto-oncogene A-Raf; serine/threonine-protein kinase A-Raf isoform 1; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf oncogene homolog 1 (murine sarcoma 3611 virus)", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); retinitis pigmentosa 49 (Disease Ontology:DOID:0110377); retinitis pigmentosa (Disease Ontology:DOID:10584); cancer (Disease Ontology:DOID:162); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:64363); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5675221)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;3449797", "class_list": "", "function": "Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). Phosphorylates PFKFB2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0035556 intracellular signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14056-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14844-1", "uniprot_id": [ { "id": "CCL2_RAT", "url": "https://www.uniprot.org/uniprot/P14844", "type": "external" } ], "mass": 16460.0, "length": 148, "protein_name": "C-C motif chemokine 2", "gene_name": "Ccl2", "organism": "Rat", "refseq_name": "C-C motif chemokine 2 precursor", "refseq_ac": [ { "id": "NP_113718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113718", "type": "external" } ], "gene_names_uniprotkb": "Ccl2; Je; Mcp1; Scya2", "gene_names_refseq": "Ccl2; MCP-1; MCP1; Scya2; Sigje", "protein_names_uniprotkb": "C-C motif chemokine 2; Immediate-early serum-responsive protein JE; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; Small-inducible cytokine A2", "protein_names_refseq": "C-C motif chemokine 2 precursor; C-C motif chemokine 2; chemokine (C-C motif) ligand 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; monocyte chemoattractant protein 1; monocyte chemotactic protein 1; small inducible cytokine A2; small inducible gene JE", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoma (Disease Ontology:DOID:1115); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); Chagas disease (Disease Ontology:DOID:12140); alcoholic hepatitis (Disease Ontology:DOID:12351); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Guillain-Barre syndrome (Disease Ontology:DOID:12842); autistic disorder (Disease Ontology:DOID:12849); cardiovascular system disease (Disease Ontology:DOID:1287); endomyocardial fibrosis (Disease Ontology:DOID:12932); intracranial vasospasm (Disease Ontology:DOID:13100); crescentic glomerulonephritis (Disease Ontology:DOID:13139); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); hepatic encephalopathy (Disease Ontology:DOID:13413); obstructive jaundice (Disease Ontology:DOID:13603); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); fungal infectious disease (Disease Ontology:DOID:1564); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); orchitis (Disease Ontology:DOID:2518); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); fibromyalgia (Disease Ontology:DOID:631); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); lipodystrophy (Disease Ontology:DOID:811); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); periodontitis (Disease Ontology:DOID:824); lung disease (Disease Ontology:DOID:850); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cholangitis (Disease Ontology:DOID:9446); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24770)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1704226;2106664;23955712;37437927;37497210;38148075;39136140;39478585", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic Pelvic Pain Model., [RefSeq, PubMed]; Ethanol-activated microglial exosomes induce MCP1 signaling mediated death of stress-regulatory proopiomelanocortin neurons in the developing hypothalamus. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA PCBP1-AS1 Induces Cerebral Ischemia/Reperfusion Injury via the miR-506-3p/CCL2 Axis., [RefSeq, PubMed]; Spinal nerve transection-induced upregulation of KDM4A in the dorsal root ganglia contributes to the development and maintenance of neuropathic pain via promoting CCL2 expression in rats., [RefSeq, PubMed]; Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 100, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q549R5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0001664 G protein-coupled receptor binding;GO:0005125 cytokine activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0030316 osteoclast differentiation;GO:0042466 chemokinesis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16228-1", "uniprot_id": [ { "id": "CATE_RAT", "url": "https://www.uniprot.org/uniprot/P16228", "type": "external" } ], "mass": 43021.0, "length": 398, "protein_name": "Cathepsin E", "gene_name": "Ctse", "organism": "Rat", "refseq_name": "cathepsin E isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001388196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388196", "type": "external" } ], "gene_names_uniprotkb": "Ctse", "gene_names_refseq": "CEA; CEB; Ctsea; Ctse", "protein_names_uniprotkb": "Cathepsin E; 3.4.23.34", "protein_names_refseq": "cathepsin E isoform 2 preproprotein", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:25424); (R-RNO-2132295)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16367762;2105725;22730688;27116544;7574663;8157122;8339772;8346912;8491674;8809073;9572291", "class_list": "", "function": "May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity)., [UniProtKB]; The mRNA and protein expression levels of MMP-12 and Cathepsin E were significantly up-regulated in lung tissues of rats with silicotic pulmonary fibrosis., [RefSeq, PubMed]; These data indicate that the catalytic activity, propeptides, and N-glycosylation of this protein are all essential for its processing, maturation, and trafficking., [RefSeq, PubMed]; These observations suggest that the overexpression of CatE interferes with neuronal differentiation of P19 cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63701", "ec_number_list": [ { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "GO:0006508 proteolysis;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P16228-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16232-1", "uniprot_id": [ { "id": "DHI1_RAT", "url": "https://www.uniprot.org/uniprot/P16232", "type": "external" } ], "mass": 31883.0, "length": 288, "protein_name": "11-beta-hydroxysteroid dehydrogenase 1", "gene_name": "Hsd11b1", "organism": "Rat", "refseq_name": "11-beta-hydroxysteroid dehydrogenase 1 isoform 1", "refseq_ac": [ { "id": "NP_058776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058776", "type": "external" } ], "gene_names_uniprotkb": "Hsd11b1; Hsd11", "gene_names_refseq": "Hsd11b1; LRRGT00065", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase 1; 1.1.1.146; 1.1.1.201; 11-DH; 11-beta-HSD1; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1", "protein_names_refseq": "11-DH; 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1 isoform 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase, type 1; 11beta-HSD1; 7-oxosteroid reductase; corticosteroid 11-beta-dehydrogenase isozyme 1; cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase, 11 beta type 1", "tax_id": 10116, "disease": "cortisone reductase deficiency (Disease Ontology:DOID:0090139); cortisone reductase deficiency 2 (Disease Ontology:DOID:0090140); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); status epilepticus (Disease Ontology:DOID:1824); coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25116); (R-RNO-194002); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10906322;12460758;1417845;14973125;1508221;1733955;21453287;2387261;2808402;33722534;3460996;35563271;37300580;38712392;8613810", "class_list": "", "function": "Addressing the role of 11beta-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model. Erratum:[Metabolism. 2026 Feb;175:156437. doi: 10.1016/j.metabol.2025.156437. PMID: 41242134], [RefSeq, PubMed]; Beta-Adrenergic Stimulation-Induced PVAT Dysfunction in Male Sex: A Role for 11beta-Hydroxysteroid Dehydrogenase-1., [RefSeq, PubMed]; Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone using NADP(H) (PubMed:12460758, PubMed:14973125, PubMed:8613810). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:12460758). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:14973125). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:14973125). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11beta-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency., [RefSeq, PubMed]; The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O09170;Q6LDH6", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0005496 steroid binding;GO:0050661 NADP binding;GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043456 regulation of pentose-phosphate shunt;GO:0006713 glucocorticoid catabolic process;GO:0030324 lung development;GO:0031667 response to nutrient levels;GO:0006704 glucocorticoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P16232-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16443-1", "uniprot_id": [ { "id": "DBP_RAT", "url": "https://www.uniprot.org/uniprot/P16443", "type": "external" } ], "mass": 34436.0, "length": 325, "protein_name": "D site-binding protein", "gene_name": "Dbp", "organism": "Rat", "refseq_name": "D site-binding protein isoform 1", "refseq_ac": [ { "id": "NP_036675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036675", "type": "external" } ], "gene_names_uniprotkb": "Dbp", "gene_names_refseq": "Dbp", "protein_names_uniprotkb": "D site-binding protein; Albumin D box-binding protein; Albumin D-element-binding protein; D site albumin promoter-binding protein 1", "protein_names_refseq": "D site albumin promoter binding protein; D site of albumin promoter (albumin D-box) binding protein; D site-binding protein isoform 1; albumin D box-binding protein; albumin D-element-binding protein; d site albumin promoter-binding protein 1; d site-binding protein", "tax_id": 10116, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24309)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10508692;12372249;21458520;21635892;22673903;2331750;23738784;25068868;31759405", "class_list": "", "function": "DBP effectively inhibits the proliferation of mesangial cells through G1 phase arrest., [RefSeq, PubMed]; Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP., [RefSeq, PubMed]; Data show that the expression of clock genes Per2, Bmal1 and Dbp follow a diurnal rhythm in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleu but the phase and amplitude of the rhythms of each gene vary across the 3 regions. Publication Status: Online-Only, [RefSeq, PubMed]; Dbp and estrogen regulate the expression of Kiss1 in the anteroventral periventricular nucleus, [RefSeq, PubMed]; Natural body temperature rhythms can affect circadian gene expression, [RefSeq, PubMed]; The localization and diurnal variation of BMAL1, DBP and PER2 are changed in remnant kidney of 5/6 nephrectomy rats and are involved in diurnal rhythm of renal function., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P16443-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16453-1", "uniprot_id": [ { "id": "DCHS_RAT", "url": "https://www.uniprot.org/uniprot/P16453", "type": "external" } ], "mass": 73636.0, "length": 656, "protein_name": "Histidine decarboxylase", "gene_name": "Hdc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hdc", "gene_names_refseq": "", "protein_names_uniprotkb": "Histidine decarboxylase; 4.1.1.22; HDC", "protein_names_refseq": "", "tax_id": 10116, "disease": "Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (rno:24443); (R-RNO-70921)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1702422;2300558", "class_list": "", "function": "Catalyzes the biosynthesis of histamine from histidine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63029", "ec_number_list": [ { "id": "4.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004398 histidine decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006548 L-histidine catabolic process;GO:0001694 histamine biosynthetic process;GO:0006547 L-histidine metabolic process;GO:0042423 catecholamine biosynthetic process;GO:0001692 histamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P16453-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17708-1", "uniprot_id": [ { "id": "DCAM_RAT", "url": "https://www.uniprot.org/uniprot/P17708", "type": "external" } ], "mass": 38137.0, "length": 333, "protein_name": "S-adenosylmethionine decarboxylase proenzyme", "gene_name": "Amd1", "organism": "Rat", "refseq_name": "S-adenosylmethionine decarboxylase proenzyme", "refseq_ac": [ { "id": "NP_112273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112273", "type": "external" } ], "gene_names_uniprotkb": "Amd1", "gene_names_refseq": "Amd1a; Amd1b; Amd1", "protein_names_uniprotkb": "S-adenosylmethionine decarboxylase proenzyme; 4.1.1.50; AdoMetDC; SAMDC", "protein_names_refseq": "S-Adenosylmethionine decarboxylase 1B; S-adenosylmethionine decarboxylase 1A; S-adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme; SAMDC; adoMetDC", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:81640); (R-RNO-351202)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1936275;2323572;2460457;8314573", "class_list": "", "function": "Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.50", "type": "external" } ], "go_molecular_function": "GO:0019810 putrescine binding;GO:0042802 identical protein binding;GO:0004014 adenosylmethionine decarboxylase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006597 spermine biosynthetic process;GO:0008295 spermidine biosynthetic process;GO:0046500 S-adenosylmethionine metabolic process;GO:0006595 polyamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17708-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17977-1", "uniprot_id": [ { "id": "CATG_RAT", "url": "https://www.uniprot.org/uniprot/P17977", "type": "external" } ], "mass": 27804.0, "length": 250, "protein_name": "Cathepsin G", "gene_name": "Ctsg", "organism": "Rat", "refseq_name": "cathepsin G precursor", "refseq_ac": [ { "id": "NP_001099511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099511", "type": "external" } ], "gene_names_uniprotkb": "Ctsg", "gene_names_refseq": "Ctsg", "protein_names_uniprotkb": "Cathepsin G; 3.4.21.20", "protein_names_refseq": "cathepsin G precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:290257); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-2022377); (R-RNO-381426); (R-RNO-448706); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "21904640;2222858;26270939", "class_list": "", "function": "CTSG is a pronociceptive mediator in animal models of chronic postsurgical pain., [RefSeq, PubMed]; Serine protease with trypsin- and chymotrypsin-like specificity. Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity. Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu. Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site. Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor. Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells. Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity. Cleaves complement C3 (By similarity). Cleaves vimentin (By similarity). Cleaves thrombin receptor F2R/PAR1. Cleaves the synovial mucin-type protein PRG4/lubricin. Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes. Cleaves IL33 into mature forms which have greater activity than the unprocessed form. Cleaves coagulation factor F8 to produce a partially activated form. Also cleaves and activates coagulation factor F10. Cleaves leukocyte cell surface protein SPN/CD43 to release its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol. Cleaves MBP in B cell lysosomes at '88-Phe-|-Lys-89' and '112-Phe-|-Ser-113', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells. Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis. Has antibacterial activity against the Gram-negative bacteria N.gonorrhoeae and P.aeruginosa. Likely to act against N.gonorrhoeae by interacting with N.gonorrhoeae penA/PBP2. Exhibits potent antimicrobial activity against the Gram-positive bacterium L.monocytogenes. Has antibacterial activity against the Gram-positive bacterium S.aureus and degrades S.aureus biofilms, allowing polymorphonuclear leukocytes to penetrate the biofilm and phagocytose bacteria. Has antibacterial activity against M.tuberculosis (By similarity). Induces platelet aggregation which is strongly potentiated in the presence of ELANE (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The results suggest that cathepsin G plays a crucial role in the degradation of 4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3V9Q7", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0008233 peptidase activity;GO:0048018 receptor ligand activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17977-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18598-1", "uniprot_id": [ { "id": "ATP4B_RAT", "url": "https://www.uniprot.org/uniprot/P18598", "type": "external" } ], "mass": 33689.0, "length": 294, "protein_name": "Potassium-transporting ATPase subunit beta", "gene_name": "Atp4b", "organism": "Rat", "refseq_name": "potassium-transporting ATPase subunit beta", "refseq_ac": [ { "id": "NP_036642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036642", "type": "external" } ], "gene_names_uniprotkb": "Atp4b", "gene_names_refseq": "Atp4b; S76401S1", "protein_names_uniprotkb": "Potassium-transporting ATPase subunit beta; Gastric H(+)/K(+) ATPase subunit beta; Proton pump beta chain", "protein_names_refseq": "ATPase H+/K+ transporting beta subunit; ATPase H+K+-transporting beta / (gastric HK-ATPase beta subunit) defined by SSR; ATPase, H+,K+-transporting, beta / (gastric H,K-ATPase beta subunit), defined by SSR; ATPase, H+/K+ exchanging, beta polypeptide; ATPase, H+/K+ transporting, beta polypeptide; gastric H(+)/K(+) ATPase subunit beta; potassium-transporting ATPase subunit beta; proton pump beta chain", "tax_id": 10116, "disease": "autoimmune gastritis (Disease Ontology:DOID:0040090); stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); atrophic gastritis (Disease Ontology:DOID:8929); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24217); (R-RNO-936837)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1657972;1663070;1978834;2165052", "class_list": "", "function": "The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0005889 potassium:proton exchanging ATPase complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0032496 response to lipopolysaccharide;GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18598-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19359-1", "uniprot_id": [ { "id": "ASCL1_RAT", "url": "https://www.uniprot.org/uniprot/P19359", "type": "external" } ], "mass": 24972.0, "length": 233, "protein_name": "Achaete-scute homolog 1", "gene_name": "Ascl1", "organism": "Rat", "refseq_name": "achaete-scute homolog 1", "refseq_ac": [ { "id": "NP_071779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071779", "type": "external" } ], "gene_names_uniprotkb": "Ascl1; Ash1; Mash-1", "gene_names_refseq": "Ascl1; Mash1", "protein_names_uniprotkb": "Achaete-scute homolog 1", "protein_names_refseq": "achaete-scute complex homolog 1; achaete-scute complex homolog-like 1; achaete-scute homolog 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:64186)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10648228;2392153;26437572;28276447;31317490;33631250;37385615", "class_list": "", "function": "Data found that Ascl1 promoted tangential migration along the ventricular zone/subventricular zone (VZ/SVZ) and intermediate zone (IZ) of the dorsal telencephalon. Also, Ascl1 induces Ephb2 expression in the telencephalon. Publication Status: Online-Only, [RefSeq, PubMed]; MASH1 induces neuron transdifferentiation of adrenal medulla chromaffin cells., [RefSeq, PubMed]; Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats., [RefSeq, PubMed]; MiR-34a appears to play an important role in the process of liver fibrosis by targeting ACSL1 and may show promise as a therapeutic molecular target for hepatic fibrosis Publication Status: Online-Only, [RefSeq, PubMed]; Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons., [RefSeq, PubMed]; Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:10648228). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043025 neuronal cell body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P19359-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19360-1", "uniprot_id": [ { "id": "ASCL2_RAT", "url": "https://www.uniprot.org/uniprot/P19360", "type": "external" } ], "mass": 27695.0, "length": 260, "protein_name": "Achaete-scute homolog 2", "gene_name": "Ascl2", "organism": "Rat", "refseq_name": "achaete-scute homolog 2", "refseq_ac": [ { "id": "NP_113691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113691", "type": "external" } ], "gene_names_uniprotkb": "Ascl2; Ash2; Mash-2; Mash2", "gene_names_refseq": "Ascl2", "protein_names_uniprotkb": "Achaete-scute homolog 2; Mash2", "protein_names_refseq": "achaete-scute complex homolog 2; achaete-scute complex homolog-like 2; achaete-scute homolog 2; mash2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); focal epilepsy (Disease Ontology:DOID:2234); schizophrenia (Disease Ontology:DOID:5419); peptic ulcer disease (Disease Ontology:DOID:750); type 2 diabetes mellitus (Disease Ontology:DOID:9352); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24209)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12196582;1314394;2392153;33649217", "class_list": "", "function": "ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development., [RefSeq, PubMed]; Transcription factor (PubMed:1314394). Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells (PubMed:12196582). May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (PubMed:12196582). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (PubMed:2392153)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0045626 negative regulation of T-helper 1 cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19360-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19377-1", "uniprot_id": [ { "id": "CD3D_RAT", "url": "https://www.uniprot.org/uniprot/P19377", "type": "external" } ], "mass": 19356.0, "length": 173, "protein_name": "T-cell surface glycoprotein CD3 delta chain", "gene_name": "Cd3d", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD3 delta chain precursor", "refseq_ac": [ { "id": "NP_037301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037301", "type": "external" } ], "gene_names_uniprotkb": "Cd3d; T3d", "gene_names_refseq": "Cd3d", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain", "protein_names_refseq": "CD3 antigen delta polypeptide; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3d molecule; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain precursor; T-cell surface glycoprotein CD3 delta chain", "tax_id": 10116, "disease": "immunodeficiency 19 (Disease Ontology:DOID:0111972); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (rno:25710); (R-RNO-198933); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-389948); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "2143819;29393594", "class_list": "", "function": "Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042101 T cell receptor complex;GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0045059 positive thymic T cell selection", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19377-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19643-1", "uniprot_id": [ { "id": "AOFB_RAT", "url": "https://www.uniprot.org/uniprot/P19643", "type": "external" } ], "mass": 58459.0, "length": 520, "protein_name": "Amine oxidase [flavin-containing] B", "gene_name": "Maob", "organism": "Rat", "refseq_name": "amine oxidase [flavin-containing] B", "refseq_ac": [ { "id": "NP_037330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037330", "type": "external" } ], "gene_names_uniprotkb": "Maob", "gene_names_refseq": "Maob", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] B; 1.4.3.21; 1.4.3.4; MAO-B; Monoamine oxidase type B", "protein_names_refseq": "MAO-B; amine oxidase [flavin-containing] B; monoamine oxidase type B", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cholestasis (Disease Ontology:DOID:13580); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:25750); (R-RNO-141333)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "20493079;27503749;2974701;34244591;34290084;35723772;4156831;6428396;9162023", "class_list": "", "function": "Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm, [RefSeq, PubMed]; Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:20493079)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Monoamine Oxidase-B Inhibition Facilitates alpha-Synuclein Secretion In Vitro and Delays Its Aggregation in rAAV-Based Rat Models of Parkinson's Disease., [RefSeq, PubMed]; Monoamine oxidase is a source of cardiac oxidative stress in obese rats: the beneficial role of metformin., [RefSeq, PubMed]; Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB5", "ec_number_list": [ { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol;GO:0048545 response to steroid hormone;GO:0009636 response to toxic substance;GO:0014063 negative regulation of serotonin secretion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19643-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19939-1", "uniprot_id": [ { "id": "APOC1_RAT", "url": "https://www.uniprot.org/uniprot/P19939", "type": "external" } ], "mass": 9861.0, "length": 88, "protein_name": "Apolipoprotein C-I", "gene_name": "Apoc1", "organism": "Rat", "refseq_name": "apolipoprotein C-I precursor", "refseq_ac": [ { "id": "NP_001103466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103466", "type": "external" } ], "gene_names_uniprotkb": "Apoc1", "gene_names_refseq": "ALPCI; Apo-CIB; ApoC-IB; Apoc1; LRRG04", "protein_names_uniprotkb": "Apolipoprotein C-I; Apo-CI; ApoC-I; Apolipoprotein C1; Liver regeneration-related protein LRRG04", "protein_names_refseq": "apo-CI; apoC-I; apolipoprotein C-I precursor; apolipoprotein C-I; liver regeneration-related protein LRRG04", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); gastric adenocarcinoma (Disease Ontology:DOID:3717); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25292); (R-RNO-8866423); (R-RNO-8964046)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2771655", "class_list": "", "function": "Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZD8", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0055102 lipase inhibitor activity;GO:0004859 phospholipase inhibitor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0005576 extracellular region", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22072-1", "uniprot_id": [ { "id": "3BHS2_RAT", "url": "https://www.uniprot.org/uniprot/P22072", "type": "external" } ], "mass": 42277.0, "length": 373, "protein_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2", "gene_name": "Hsd3b3; Hsd3b", "organism": "Rat", "refseq_name": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2", "refseq_ac": [ { "id": "NP_001036084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036084", "type": "external" } ], "gene_names_uniprotkb": "Hsd3b3; Hsd3b", "gene_names_refseq": "Hsd3b3; Hsd3b", "protein_names_uniprotkb": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; Delta-5-3-ketosteroid isomerase; Progesterone reductase", "protein_names_refseq": "3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type 3; 3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type II; 3-beta-HSD II", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (rno:682974); (R-RNO-193048); (R-RNO-193993); (R-RNO-194002)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1944305;19698287;1985917", "class_list": "", "function": "3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids., [UniProtKB]; Letrozole-induced polycystic ovaries showed increased 3beta-HSD expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" } ], "go_molecular_function": "GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity;GO:0004769 steroid Delta-isomerase activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0008207 C21-steroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22072-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22283-1", "uniprot_id": [ { "id": "22P2_RAT", "url": "https://www.uniprot.org/uniprot/P22283", "type": "external" } ], "mass": 21013.0, "length": 176, "protein_name": "Cystatin-related protein 2", "gene_name": "Crp2; P22k15", "organism": "Rat", "refseq_name": "cystatin-related protein 2 precursor", "refseq_ac": [ { "id": "NP_954887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954887", "type": "external" } ], "gene_names_uniprotkb": "Crp2; P22k15; P22k15", "gene_names_refseq": "Crp2; P22k15", "protein_names_uniprotkb": "Cystatin-related protein 2; Prostatic 22 kDa glycoprotein P22K15", "protein_names_refseq": "cystatin-related protein 2 precursor; prostatic 22 kDa glycoprotein P22K15; prostatic 22-kD glycoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:296229)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2280780;7679983;8462870", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497B4", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22283-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23457-1", "uniprot_id": [ { "id": "DIDH_RAT", "url": "https://www.uniprot.org/uniprot/P23457", "type": "external" } ], "mass": 37028.0, "length": 322, "protein_name": "3-alpha-hydroxysteroid dehydrogenase", "gene_name": "Akr1c9", "organism": "Rat", "refseq_name": "3-alpha-hydroxysteroid dehydrogenase", "refseq_ac": [ { "id": "NP_612556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612556", "type": "external" } ], "gene_names_uniprotkb": "Akr1c9", "gene_names_refseq": "Akr1c14; Akr1c9", "protein_names_uniprotkb": "3-alpha-hydroxysteroid dehydrogenase; 1.1.1.50; 3-alpha-HSD; Hydroxyprostaglandin dehydrogenase", "protein_names_refseq": "3-alpha-HSD; 3-alpha-hydroxysteroid dehydrogenase; hydroxyprostaglandin dehydrogenase; steroid 3-alpha-dehydrogenase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); ductal carcinoma in situ (Disease Ontology:DOID:0060074); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); 46,XY sex reversal 8 (Disease Ontology:DOID:0111773); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); leukemia (Disease Ontology:DOID:1240); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:191574); (R-RNO-193368); (R-RNO-193775); (R-RNO-193807); (R-RNO-2162123); (R-RNO-5365859); (R-RNO-975634); (R-RNO-9757110)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10619355;1714456;1793046;1840601;1922097;2026597;22217852;28552457;28707553;7515872;7626489;7998972;8146147;8718859;9261071", "class_list": "", "function": "Besides being a 3-alpha-hydroxysteroid dehydrogenase, the enzyme can accomplish diverse functions: as quinone reductase, as an aromatic alcohol dehydrogenase, as dihydrodiol dehydrogenase, and as 9-, 11-, and 15-hydroxyprostaglandin dehydrogenase., [UniProtKB]; Butylated hydroxyanisole alters rat 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase: Implications for influences of neurosteroidogenesis., [RefSeq, PubMed]; Characterization of recombinant 3-alpha-hydroxysteroid dehydrogenase from liver: molecular weight; amino acid sequence; sequence alignment and homology with similar enzymes; inhibition by indomethacin, [RefSeq, PubMed]; Ziram inhibited SRD5A1 and AKR1C14 activities, thus possibly interfering with neurosteroid production in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKC8;Q6LDE6;Q6LDE7", "ec_number_list": [ { "id": "1.1.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.50", "type": "external" }, { "id": "1.1.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.149", "type": "external" }, { "id": "1.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.-.-", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004032 aldose reductase (NADPH) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0032052 bile acid binding;GO:0047086 ketosteroid monooxygenase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006710 androgen catabolic process;GO:0021766 hippocampus development;GO:0006693 prostaglandin metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P23457-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23571-1", "uniprot_id": [ { "id": "3MG_RAT", "url": "https://www.uniprot.org/uniprot/P23571", "type": "external" } ], "mass": 34814.0, "length": 317, "protein_name": "DNA-3-methyladenine glycosylase", "gene_name": "Mpg", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mpg", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-3-methyladenine glycosylase; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3.2.2.21; ADPG; N-methylpurine-DNA glycosylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24561); (R-RNO-110331); (R-RNO-110357)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1698614", "class_list": "", "function": "Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.21", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003905 alkylbase DNA N-glycosylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23571-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24268-1", "uniprot_id": [ { "id": "CATD_RAT", "url": "https://www.uniprot.org/uniprot/P24268", "type": "external" } ], "mass": 44681.0, "length": 407, "protein_name": "Cathepsin D", "gene_name": "Ctsd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctsd", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathepsin D; 3.4.23.5", "protein_names_refseq": "", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); neuronal ceroid lipofuscinosis 10 (Disease Ontology:DOID:0110725); Alzheimer's disease (Disease Ontology:DOID:10652); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:171293); (R-RNO-1442490); (R-RNO-2022377); (R-RNO-2132295); (R-RNO-6798695); (R-RNO-77387)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1039/D0MO00044B;1883350;2243802;24090084;3182800;34106099;37442287;38843836", "class_list": "", "function": "Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.4.22.38", "url": 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"go_molecular_function": "GO:0004175 endopeptidase activity;GO:0016787 hydrolase activity;GO:0042277 peptide binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031904 endosome lumen;GO:0045121 membrane raft", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0031667 response to nutrient levels;GO:0097194 execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P24268-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24338-1", "uniprot_id": [ { "id": "AREG_RAT", "url": "https://www.uniprot.org/uniprot/P24338", "type": "external" } ], "mass": 26633.0, "length": 243, "protein_name": "Amphiregulin", "gene_name": "Areg", "organism": "Rat", "refseq_name": "amphiregulin preproprotein", "refseq_ac": [ { "id": "NP_058819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058819", "type": "external" } ], "gene_names_uniprotkb": "Areg; Sdgf", "gene_names_refseq": "Areg", "protein_names_uniprotkb": "Amphiregulin; AR; SDGF; Schwannoma-derived growth factor", "protein_names_refseq": "AR; SDGF; amphiregulin preproprotein; schwannoma-derived growth factor", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:29183); (R-RNO-1257604); (R-RNO-177929); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-204005); (R-RNO-212718); (R-RNO-5673001); (R-RNO-5694530); (R-RNO-6811558); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9009391)", "pathway_count": 15, "publication_count": 5, "publication_id_list": "21258428;2234093;24816162;30773606;35996142", "class_list": "", "function": "Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Estrogen and progeterone increased cell proliferation in normal gland and mammary cancers through the increased production of amphiregulin, [RefSeq, PubMed]; Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts., [UniProtKB]; Report increased AREG transcript and protein levels in the lungs of rodents with DA-induced bronchiolitis obliterans., [RefSeq, PubMed]; Study demonstrated that miR-449a was downregulated while AREG was upregulated in cerebral ischemic injury, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0042542 response to hydrogen peroxide;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P24338-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24485-1", "uniprot_id": [ { "id": "CD53_RAT", "url": "https://www.uniprot.org/uniprot/P24485", "type": "external" } ], "mass": 24168.0, "length": 219, "protein_name": "Leukocyte surface antigen CD53", "gene_name": "Cd53", "organism": "Rat", "refseq_name": "leukocyte surface antigen CD53", "refseq_ac": [ { "id": "NP_036655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036655", "type": "external" } ], "gene_names_uniprotkb": "Cd53; Ox-44", "gene_names_refseq": "Cd53; OX44; Ox-44", "protein_names_uniprotkb": "Leukocyte surface antigen CD53; Cell surface glycoprotein CD53; Leukocyte antigen MRC OX-44", "protein_names_refseq": "CD53 antigen; cell surface glycoprotein CD53; leukocyte antigen MRC OX-44; leukocyte surface antigen CD53", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:24251); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2017181;2466944;24832104", "class_list": "", "function": "CD53 may shift natural killer cell responses from effector functions towards a proliferation phase. Publication Status: Online-Only, [RefSeq, PubMed]; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0001772 immunological synapse;GO:0016020 membrane", "go_biological_process": "GO:0040008 regulation of growth;GO:1901741 positive regulation of myoblast fusion;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24485-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25108-1", "uniprot_id": [ { "id": "ACHA_RAT", "url": "https://www.uniprot.org/uniprot/P25108", "type": "external" } ], "mass": 51867.0, "length": 457, "protein_name": "Acetylcholine receptor subunit alpha", "gene_name": "Chrna1", "organism": "Rat", "refseq_name": "acetylcholine receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_077811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077811", "type": "external" } ], "gene_names_uniprotkb": "Chrna1; Acra", "gene_names_refseq": "Chrna1", "protein_names_uniprotkb": "Acetylcholine receptor subunit alpha", "protein_names_refseq": "acetylcholine receptor subunit alpha precursor; acetylcholine receptor subunit alpha; cholinergic receptor nicotinic alpha polypeptide 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)", "tax_id": 10116, "disease": "congenital myasthenic syndrome 1B (Disease Ontology:DOID:0110662); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); alcohol use disorder (Disease Ontology:DOID:1574); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (rno:79557); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1702709", "class_list": "", "function": "Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0009986 cell surface;GO:0016020 membrane;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007528 neuromuscular junction development;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25108-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25109-1", "uniprot_id": [ { "id": "ACHB_RAT", "url": "https://www.uniprot.org/uniprot/P25109", "type": "external" } ], "mass": 57027.0, "length": 501, "protein_name": "Acetylcholine receptor subunit beta", "gene_name": "Chrnb1", "organism": "Rat", "refseq_name": "acetylcholine receptor subunit beta isoform 2 precursor", "refseq_ac": [ { "id": "NP_036660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036660", "type": "external" } ], "gene_names_uniprotkb": "Chrnb1; Acrb", "gene_names_refseq": "Acrb; Chrnb1; RNACRB1; nAChR", "protein_names_uniprotkb": "Acetylcholine receptor subunit beta", "protein_names_refseq": "Acetylcholine receptor beta; acetylcholine receptor subunit beta isoform 2 precursor; acetylcholine receptor subunit beta; cholinergic receptor nicotinic beta polypeptide 1; cholinergic receptor, nicotinic beta 1; cholinergic receptor, nicotinic, beta 1 (muscle); cholinergic receptor, nicotinic, beta polypeptide 1 (muscle); n acetylcholine receptor", "tax_id": 10116, "disease": "congenital myasthenic syndrome 2C (Disease Ontology:DOID:0110680); congenital myasthenic syndrome 2A (Disease Ontology:DOID:0110681)", "pathway": " (rno:24261)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1702709;31172341", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB]; Inhibition of p38 can post-transcriptionally inhibit beta-AChR upregulation via HuR in denervated skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0015267 channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P25109-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25110-1", "uniprot_id": [ { "id": "ACHD_RAT", "url": "https://www.uniprot.org/uniprot/P25110", "type": "external" } ], "mass": 58884.0, "length": 517, "protein_name": "Acetylcholine receptor subunit delta", "gene_name": "Chrnd", "organism": "Rat", "refseq_name": "acetylcholine receptor subunit delta precursor", "refseq_ac": [ { "id": "NP_062171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062171", "type": "external" } ], "gene_names_uniprotkb": "Chrnd; Acrd", "gene_names_refseq": "Chrnd", "protein_names_uniprotkb": "Acetylcholine receptor subunit delta", "protein_names_refseq": "acetylcholine receptor subunit delta precursor; acetylcholine receptor subunit delta; cholinergic receptor, nicotinic delta; cholinergic receptor, nicotinic, delta (muscle); cholinergic receptor, nicotinic, delta polypeptide; nicotinic acetylcholine receptor delta-subunit", "tax_id": 10116, "disease": "congenital myasthenic syndrome 3C (Disease Ontology:DOID:0110664); congenital myasthenic syndrome 3B (Disease Ontology:DOID:0110665); congenital myasthenic syndrome 3A (Disease Ontology:DOID:0110666); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); congenital myasthenic syndrome (Disease Ontology:DOID:3635); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:54240); (R-RNO-629587)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10201407;1638981;1702709", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0042391 regulation of membrane potential;GO:0048630 skeletal muscle tissue growth;GO:0050881 musculoskeletal movement;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P25110-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26255-1", "uniprot_id": [ { "id": "ADRB3_RAT", "url": "https://www.uniprot.org/uniprot/P26255", "type": "external" } ], "mass": 43146.0, "length": 400, "protein_name": "Beta-3 adrenergic receptor", "gene_name": "Adrb3", "organism": "Rat", "refseq_name": "beta-3 adrenergic receptor", "refseq_ac": [ { "id": "NP_037240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037240", "type": "external" } ], "gene_names_uniprotkb": "Adrb3; Adrb3r", "gene_names_refseq": "ADRB; Adrb3", "protein_names_uniprotkb": "Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor", "protein_names_refseq": "adrenergic receptor, beta 3; adrenergic, beta-3-, receptor; beta-3 adrenergic receptor; beta-3 adrenoceptor; beta-3 adrenoreceptor", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); polycystic ovary syndrome (Disease Ontology:DOID:11612); gout (Disease Ontology:DOID:13189); endometrial cancer (Disease Ontology:DOID:1380); cystic fibrosis (Disease Ontology:DOID:1485); coronary artery disease (Disease Ontology:DOID:3393); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25645); (R-RNO-390696)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10207024;1684635;1721063;30613975;31295748;36884028;38278068;38662592;8382630", "class_list": "", "function": "Beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure., [RefSeq, PubMed]; Blocking brown adipocyte beta3-adrenoceptor attenuates blood-spinal cord barrier impairment and chronic postsurgical pain in a rat model of preoperative stress., [RefSeq, PubMed]; ENDOGENOUS beta 3 -ADRENERGIC RECEPTOR ACTIVATION ALLEVIATES SEPSIS-INDUCED CARDIOMYOCYTE APOPTOSIS VIA PI3K/AKT SIGNALING PATHWAY., [RefSeq, PubMed]; G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:10207024). The rank order of potency for physiological agonists is norepinephrine > epinephrine (By similarity). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (PubMed:10207024). Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade (PubMed:10207024). Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling (By similarity)., [UniProtKB, UniProtKB, PubMed]; Present data can emphasize the important deleterious effect of beta3 -AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between beta3 -AR activation, NO-signaling, and [Zn(2+) ]i pathways., [RefSeq, PubMed]; Voluntary exercise induced opposite changes in the gene expression of beta3-adrenergic receptors in the white and in the brown adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051379 epinephrine binding;GO:0051380 norepinephrine binding;GO:0004939 beta-adrenergic receptor activity;GO:0015052 beta3-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0009409 response to cold;GO:0043410 positive regulation of MAPK cascade;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P26255-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27867-1", "uniprot_id": [ { "id": "DHSO_RAT", "url": "https://www.uniprot.org/uniprot/P27867", "type": "external" } ], "mass": 38235.0, "length": 357, "protein_name": "Sorbitol dehydrogenase", "gene_name": "Sord", "organism": "Rat", "refseq_name": "sorbitol dehydrogenase", "refseq_ac": [ { "id": "NP_058748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058748", "type": "external" } ], "gene_names_uniprotkb": "Sord; Sdh1", "gene_names_refseq": "SDH; Sord; XDH", "protein_names_uniprotkb": "Sorbitol dehydrogenase; 1.1.1.-; 1.1.1.14; 1.1.1.9; L-iditol 2-dehydrogenase; Polyol dehydrogenase; SDH; XDH; Xylitol dehydrogenase", "protein_names_refseq": "L-iditol 2-dehydrogenase; polyol dehydrogenase; sorbitol dehydrogenase; xylitol dehydrogenase", "tax_id": 10116, "disease": "autosomal recessive distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0081427); cataract (Disease Ontology:DOID:83); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:24788); (R-RNO-5652227); (R-RNO-5661270)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11306057;2050152;22673903;38538210;6862079;8223590", "class_list": "", "function": "Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6862079). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SORD-deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VCV9;Q4FZY4;Q5I0F3", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.1.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.14", "type": "external" }, { "id": "1.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.9", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity;GO:0046526 D-xylulose reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane;GO:0031514 motile cilium;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006060 sorbitol metabolic process;GO:0030317 flagellated sperm motility;GO:0031667 response to nutrient levels;GO:0046686 response to cadmium ion;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P27867-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28470-1", "uniprot_id": [ { "id": "CANB2_RAT", "url": "https://www.uniprot.org/uniprot/P28470", "type": "external" } ], "mass": 20291.0, "length": 176, "protein_name": "Calcineurin subunit B type 2", "gene_name": "Ppp3r2", "organism": "Rat", "refseq_name": "calcineurin subunit B type 2", "refseq_ac": [ { "id": "NP_067733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067733", "type": "external" } ], "gene_names_uniprotkb": "Ppp3r2; Cblp", "gene_names_refseq": "Cblp; Ppp3r2", "protein_names_uniprotkb": "Calcineurin subunit B type 2; CBLP; Calcineurin B-like protein; Protein phosphatase 2B regulatory subunit 2; Protein phosphatase 3 regulatory subunit B beta isoform", "protein_names_refseq": "calcineurin B, type II; calcineurin B-like protein; calcineurin subunit B type 2; protein phosphatase 2B regulatory subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29749)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16903851;1718268;17324936;17827263", "class_list": "", "function": "Calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation, [RefSeq, PubMed]; In conclusion, CsA normalized the blunted beta-AR responsiveness associated with hypertension., [RefSeq, PubMed]; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity., [UniProtKB, UniProtKB]; These data suggest that BK(Ca) channel activity is inhibited by calcineurin, an effect mediated by the association of the calcineurin B subunit with the carboxyl terminus of the channel., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63878", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019902 phosphatase binding;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28470-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28564-1", "uniprot_id": [ { "id": "5HT1B_RAT", "url": "https://www.uniprot.org/uniprot/P28564", "type": "external" } ], "mass": 43163.0, "length": 386, "protein_name": "5-hydroxytryptamine receptor 1B", "gene_name": "Htr1b", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 1B", "refseq_ac": [ { "id": "NP_071561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071561", "type": "external" } ], "gene_names_uniprotkb": "Htr1b; 5ht1b", "gene_names_refseq": "Htr1b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; Serotonin receptor 1B", "protein_names_refseq": "5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine receptor 1B; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); antisocial personality disorder (Disease Ontology:DOID:10939); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); substance abuse (Disease Ontology:DOID:302); ischemia (Disease Ontology:DOID:326); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25075); (R-RNO-390666); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1836757;31468338;32574671;34061415;38750961", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1836757, Ref.1). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (By similarity). Besides, plays a role in vasoconstriction of cerebral arteries (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats., [RefSeq, PubMed]; Lateral habenula 5-HT1B receptors are involved in regulation of anxiety-like behaviors in parkinsonian rats., [RefSeq, PubMed]; Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias., [RefSeq, PubMed]; The protective effect of alpha7-nACh receptor and its interaction with 5-HT1B/1D receptors in acute intestinal ischemia-reperfusion injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045471 response to ethanol;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0014059 regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28564-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29276-1", "uniprot_id": [ { "id": "AA2BR_RAT", "url": "https://www.uniprot.org/uniprot/P29276", "type": "external" } ], "mass": 36367.0, "length": 332, "protein_name": "Adenosine receptor A2b", "gene_name": "Adora2b", "organism": "Rat", "refseq_name": "adenosine receptor A2b", "refseq_ac": [ { "id": "NP_058857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058857", "type": "external" } ], "gene_names_uniprotkb": "Adora2b", "gene_names_refseq": "Adora2b", "protein_names_uniprotkb": "Adenosine receptor A2b", "protein_names_refseq": "adenosine receptor A2b", "tax_id": 10116, "disease": "", "pathway": " (rno:29316); (R-RNO-417973); (R-RNO-5683826)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1333049;1584214;34288817;35653908;36330948;37402944;38874549", "class_list": "", "function": "A1 and A2b adenosine receptors regulate GPX4 against ferroptosis of cardiomyocytes in myocardial infarction rat model and in vitro., [RefSeq, PubMed]; Activation of basal forebrain cholinergic neurons improves colonic hyperpermeability through the vagus nerve and adenosine A2B receptors in rats., [RefSeq, PubMed]; Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension., [RefSeq, PubMed]; Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor., [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB]; Targeting Adenosine A2b Receptor Promotes Penile Rehabilitation of Refractory Erectile Dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001609 G protein-coupled adenosine receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0098793 presynapse", "go_biological_process": "GO:0010701 positive regulation of norepinephrine secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0002882 positive regulation of chronic inflammatory response to non-antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29276-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30099-1", "uniprot_id": [ { "id": "C11B2_RAT", "url": "https://www.uniprot.org/uniprot/P30099", "type": "external" } ], "mass": 58241.0, "length": 510, "protein_name": "Cytochrome P450 11B2, mitochondrial", "gene_name": "Cyp11b2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp11b2; Cyp11b-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 11B2, mitochondrial; 1.14.15.4; 1.14.15.5; ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; CYPXIB2; Corticosterone 18-monooxygenase, CYP11B2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450(11beta,aldo); Cytochrome P450-Aldo-1; P450(11beta,aldo); Steroid 11-beta-hydroxylase, CYP11B2; Steroid 18-hydroxylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); glucocorticoid-remediable aldosteronism (Disease Ontology:DOID:14080); renal tubular acidosis (Disease Ontology:DOID:14219); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); myocarditis (Disease Ontology:DOID:820)", "pathway": " (R-RNO-194002); (R-RNO-211976)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1562515;1765101;2350348;2738055;8333830;8468320", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid responsible for salt and water homeostasis (PubMed:1562515, PubMed:1765101, PubMed:2350348, PubMed:2738055). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone (21-hydroxyprogesterone), namely 11-beta hydroxylation, followed by two successive oxidations at C18 yielding 18-hydroxy and then 18-oxo intermediates (that do not leave the enzyme active site during the consecutive hydroxylation reactions), and end with the formation of aldosterone (PubMed:1765101, PubMed:2350348, PubMed:2738055, PubMed:8333830). Can also produce 18-hydroxycortisol and 18-oxocortisol, derived from successive oxidations of cortisol at C18, normally found at very low levels, but significantly increased in primary aldosteronism, the most common form of secondary hypertension (By similarity) (PubMed:1562515). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Besides its role in the biosynthesis of mineralocorticoids and glucocorticoids, it can also participate in the androgen metabolic pathway, converting testosterone (17beta-hydroxy-4-androsten-3-one) to 11beta,17beta-dihydroxyandrost-4-ene-3-one (By similarity). Can also use progesterone as substrate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64540", "ec_number_list": [ { "id": "1.14.15.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0051365 cellular response to potassium ion starvation;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30099-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30100-1", "uniprot_id": [ { "id": "C11B3_RAT", "url": "https://www.uniprot.org/uniprot/P30100", "type": "external" } ], "mass": 57122.0, "length": 500, "protein_name": "Cytochrome P450 11B3, mitochondrial", "gene_name": "Cyp11b3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp11b3; Cyp11b-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 11B3, mitochondrial; 1.14.15.4; CYP11B3; CYPXIB3; Cytochrome P-450 11B3; Cytochrome P450-Aldo-2; Steroid 11-beta-hydroxylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); stroke (Disease Ontology:DOID:0051061); corticosterone methyloxidase deficiency 1 (Disease Ontology:DOID:0080626); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); glucocorticoid-remediable aldosteronism (Disease Ontology:DOID:14080); primary hyperaldosteronism (Disease Ontology:DOID:446); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-193993); (R-RNO-194002); (R-RNO-211976)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1562515;2129527;2350348;2738055;8468320;8473352;8674838", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:8674838). Catalyzes the hydroxylation of steroids at 11beta, 18- or 19-positions, with preferred regioselectivity at 11beta and 18 (PubMed:8674838). Converts 11-deoxycorticosterone into corticosterone, 18-hydroxy-11-deoxycorticosterone, and/or 19-hydroxy-11-deoxycorticosterone, but not to 18-hydroxycorticosterone or aldosterone (PubMed:8674838). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0030425 dendrite", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0051365 cellular response to potassium ion starvation;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31211-1", "uniprot_id": [ { "id": "CBG_RAT", "url": "https://www.uniprot.org/uniprot/P31211", "type": "external" } ], "mass": 44671.0, "length": 396, "protein_name": "Corticosteroid-binding globulin", "gene_name": "Serpina6", "organism": "Rat", "refseq_name": "corticosteroid-binding globulin precursor", "refseq_ac": [ { "id": "NP_001009663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009663", "type": "external" } ], "gene_names_uniprotkb": "Serpina6; Cbg", "gene_names_refseq": "Cbg; Serpina6", "protein_names_uniprotkb": "Corticosteroid-binding globulin; CBG; Serpin A6; Transcortin", "protein_names_refseq": "Corticosteroid binding globulin; corticosteroid-binding globulin precursor; corticosteroid-binding globulin; serine (or cysteine) peptidase inhibitor, clade A, member 6; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin A6; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; serpin peptidase inhibitor, clade A, member 6; transcortin", "tax_id": 10116, "disease": "corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030)", "pathway": " (rno:299270); (R-RNO-194002); (R-RNO-9757110)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17644521;21454685;23279724;2710140;27418032;29273683;3347061;36112420;38015819", "class_list": "", "function": "Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual Dimorphism of Adult Rat Liver., [RefSeq, PubMed]; Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development., [RefSeq, PubMed]; It is most likely that CBG in the brain may be involved in the response to changing systemic glucocorticoid levels., [RefSeq, PubMed]; Levels and integrity of plasma CBG are biomarkers of the onset and severity of inflammation, [RefSeq, PubMed]; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species., [UniProtKB, PubMed]; N-glycans at other sites also appear to protect CBG from neutrophil elastase or chymotrypsin., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5M822", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005496 steroid binding;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008211 glucocorticoid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31211-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31399-1", "uniprot_id": [ { "id": "ATP5H_RAT", "url": "https://www.uniprot.org/uniprot/P31399", "type": "external" } ], "mass": 18763.0, "length": 161, "protein_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "gene_name": "Atp5pd", "organism": "Rat", "refseq_name": "ATP synthase peripheral stalk subunit d, mitochondrial", "refseq_ac": [ { "id": "NP_062256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062256", "type": "external" } ], "gene_names_uniprotkb": "Atp5pd; Atp5h; Atp5jd", "gene_names_refseq": "Atp5h; Atp5jd; Atp5pd; Atpq", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase peripheral stalk subunit d; ATPase subunit d", "protein_names_refseq": "ATP synthase peripheral stalk subunit d, mitochondrial; ATP synthase subunit d, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d; ATPase subunit d", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:641434); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1531750;17575325;26446791;26519110;34502162;38843836;7509337", "class_list": "", "function": "Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The deltaPKC-dF1Fo inhibitor attenuated co-immunoprecipitation of deltaPKC with dF1Fo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:1901653 cellular response to peptide;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31399-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31720-1", "uniprot_id": [ { "id": "C1QA_RAT", "url": "https://www.uniprot.org/uniprot/P31720", "type": "external" } ], "mass": 25917.0, "length": 245, "protein_name": "Complement C1q subcomponent subunit A", "gene_name": "C1qa", "organism": "Rat", "refseq_name": "complement C1q subcomponent subunit A precursor", "refseq_ac": [ { "id": "NP_001008515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008515", "type": "external" } ], "gene_names_uniprotkb": "C1qa", "gene_names_refseq": "Adic; C1qa", "protein_names_uniprotkb": "Complement C1q subcomponent subunit A", "protein_names_refseq": "adiponectin c; complement C1q subcomponent subunit A precursor; complement C1q subcomponent subunit A; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide", "tax_id": 10116, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:298566); (R-RNO-173623); (R-RNO-977606)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "23150673;24939307;29393594;8464426", "class_list": "", "function": "C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity, [RefSeq, PubMed]; Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]; Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJK1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0001774 microglial cell activation;GO:0016322 neuron remodeling;GO:0045087 innate immune response;GO:0048143 astrocyte activation;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31720-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31722-1", "uniprot_id": [ { "id": "C1QC_RAT", "url": "https://www.uniprot.org/uniprot/P31722", "type": "external" } ], "mass": 25686.0, "length": 245, "protein_name": "Complement C1q subcomponent subunit C", "gene_name": "C1qc", "organism": "Rat", "refseq_name": "complement C1q subcomponent subunit C precursor", "refseq_ac": [ { "id": "NP_001008524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008524", "type": "external" } ], "gene_names_uniprotkb": "C1qc; C1qg", "gene_names_refseq": "Adib; C1qc; C1qg", "protein_names_uniprotkb": "Complement C1q subcomponent subunit C", "protein_names_refseq": "adiponectin b; complement C1q subcomponent subunit C precursor; complement C1q subcomponent subunit C; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide", "tax_id": 10116, "disease": "", "pathway": " (rno:362634); (R-RNO-173623); (R-RNO-977606)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21454685;24939307;8464426", "class_list": "", "function": "Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system., [UniProtKB, UniProtKB]; Data suggest that complement C1q expression may play a principal role in hepatic ischemia-reperfusion (I/R) injury, particularly at the early stage of perfusion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJZ8", "ec_number_list": [], "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0001791 IgM binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0030853 negative regulation of granulocyte differentiation;GO:0045650 negative regulation of macrophage differentiation;GO:0098883 synapse pruning;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35213-1", "uniprot_id": [ { "id": "1433B_RAT", "url": "https://www.uniprot.org/uniprot/P35213", "type": "external" } ], "mass": 28054.0, "length": 246, "protein_name": "14-3-3 protein beta/alpha", "gene_name": "Ywhab", "organism": "Rat", "refseq_name": "14-3-3 protein beta/alpha", "refseq_ac": [ { "id": "NP_062250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062250", "type": "external" } ], "gene_names_uniprotkb": "Ywhab", "gene_names_refseq": "Ywhab", "protein_names_uniprotkb": "14-3-3 protein beta/alpha; KCIP-1; Prepronerve growth factor RNH-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; KCIP-1; prepronerve growth factor RNH-1; protein kinase C inhibitor protein 1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:56011); (R-RNO-111447); (R-RNO-165159); (R-RNO-170968); (R-RNO-2028269); (R-RNO-392517); (R-RNO-450385); (R-RNO-450513); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5675221); (R-RNO-75035); (R-RNO-9614399)", "pathway_count": 15, "publication_count": 9, "publication_id_list": "11427721;11555644;18683930;26438180;28684312;29749466;34502162;8381897;8749325", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13., [UniProtKB, UniProtKB]; The expression of YWHAB was upregulated by oleic acid in a concentrationdependent manner in vascular smooth muscle cells., [RefSeq, PubMed]; The results indicate that hyperglycemia-induced up-regulation of YWHAB in endothelial cell plays a significant role in intimal hyperplasia following carotid artery injury by enhancing endothelial cell proliferation and migration., [RefSeq, PubMed]; This study reveals that 14-3-3 gamma protein is present in oligodendroglial cells and that 14-3-3 gamma deficiency leads to more severe chronic EAE with enhanced demyelination. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0050815 phosphoserine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006605 protein targeting;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P35213-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36576-1", "uniprot_id": [ { "id": "ARRC_RAT", "url": "https://www.uniprot.org/uniprot/P36576", "type": "external" } ], "mass": 9878.0, "length": 92, "protein_name": "Arrestin-C", "gene_name": "Arr3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arr3; Car", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin-C; Cone arrestin; Retinal cone arrestin-3; cArr", "protein_names_refseq": "", "tax_id": 10116, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (rno:171107)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8308033", "class_list": "", "function": "May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0051219 phosphoprotein binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0045202 synapse;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007601 visual perception;GO:0009968 negative regulation of signal transduction;GO:0001932 regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36576-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36577-1", "uniprot_id": [ { "id": "ARRD_RAT", "url": "https://www.uniprot.org/uniprot/P36577", "type": "external" } ], "mass": 7755.0, "length": 71, "protein_name": "Arrestin-D", "gene_name": "Dar", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dar", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin-D", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8308033", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36577-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37136-1", "uniprot_id": [ { "id": "ACES_RAT", "url": "https://www.uniprot.org/uniprot/P37136", "type": "external" } ], "mass": 68196.0, "length": 614, "protein_name": "Acetylcholinesterase", "gene_name": "Ache", "organism": "Rat", "refseq_name": "acetylcholinesterase precursor", "refseq_ac": [ { "id": "NP_742006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742006", "type": "external" } ], "gene_names_uniprotkb": "Ache", "gene_names_refseq": "Ache", "protein_names_uniprotkb": "Acetylcholinesterase; 3.1.1.7; AChE", "protein_names_refseq": "acetylcholinesterase precursor; glycolipid-anchored form of acetylcholinesterase", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); Hirschsprung's disease (Disease Ontology:DOID:10487); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); leptospirosis (Disease Ontology:DOID:2297); multiple sclerosis (Disease Ontology:DOID:2377); myasthenia gravis (Disease Ontology:DOID:437); acute stress disorder (Disease Ontology:DOID:6088); subacute delirium (Disease Ontology:DOID:8645); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:83817)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "28849127;28916328;8417155;8417973", "class_list": "", "function": "Paraquat-induced death of hippocampal neurons was partially mediated by AChE variants inducing and cholinergic and gultamatergic transmission disruption., [RefSeq, PubMed]; Sepsis decreased AChE activity by reducing its expression at the neuromuscular junction., [RefSeq, PubMed]; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.7", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042166 acetylcholine binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019695 choline metabolic process;GO:0007155 cell adhesion;GO:0031623 receptor internalization;GO:0035094 response to nicotine;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P37136-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37200-1", "uniprot_id": [ { "id": "ARRE_RAT", "url": "https://www.uniprot.org/uniprot/P37200", "type": "external" } ], "mass": 8133.0, "length": 72, "protein_name": "Arrestin-E", "gene_name": "Ear", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ear", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin-E", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8308033", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P37200-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38483-1", "uniprot_id": [ { "id": "ABEC1_RAT", "url": "https://www.uniprot.org/uniprot/P38483", "type": "external" } ], "mass": 27274.0, "length": 229, "protein_name": "C->U-editing enzyme APOBEC-1", "gene_name": "Apobec1", "organism": "Rat", "refseq_name": "C->U-editing enzyme APOBEC-1", "refseq_ac": [ { "id": "NP_037039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037039", "type": "external" } ], "gene_names_uniprotkb": "Apobec1", "gene_names_refseq": "Apobec1; REPR; apobec-1", "protein_names_uniprotkb": "C->U-editing enzyme APOBEC-1; 3.5.4.-; 3.5.4.36; APOBEC-1; Apo B messenger RNA-editing protein; Apolipoprotein B mRNA-editing enzyme 1; Apolipoprotein B mRNA-editing enzyme catalytic subunit 1; REPR; mRNA(cytosine(6666)) deaminase 1", "protein_names_refseq": "Apolipoprotein B editing protein; C->U-editing enzyme APOBEC-1; apo B messenger RNA-editing protein; apolipoprotein B editing complex 1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; apolipoprotein B mRNA-editing enzyme 1; mRNA(cytosine(6666)) deaminase 1", "tax_id": 10116, "disease": "familial hyperlipidemia (Disease Ontology:DOID:1168); colon cancer (Disease Ontology:DOID:219); liver benign neoplasm (Disease Ontology:DOID:916); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25383); (R-RNO-72200); (R-RNO-75094)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10669759;11134005;23609497;25085003;29553573;8511591", "class_list": "", "function": "Apobec-1 increased COX-2 expression and COX-2 mRNA stabilization in neurogenic cells, and failed to catalyze C-to-U editing of COX-2 mRNA, [RefSeq, PubMed]; Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs. Form complexes with cofactors that confer differential editing activity and selectivity. Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:8511591). Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (By similarity). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. Erratum:[Genome Biol. 2014;15(11):497] Publication Status: Online-Only, [RefSeq, PubMed]; To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.-", "type": "external" }, { "id": "3.5.4.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.36", "type": "external" }, { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0004126 cytidine deaminase activity;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030895 apolipoprotein B mRNA editing enzyme complex", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006397 mRNA processing;GO:0006641 triglyceride metabolic process;GO:0010043 response to zinc ion;GO:0010332 response to gamma radiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P38483-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39948-1", "uniprot_id": [ { "id": "CCND1_RAT", "url": "https://www.uniprot.org/uniprot/P39948", "type": "external" } ], "mass": 33483.0, "length": 295, "protein_name": "G1/S-specific cyclin-D1", "gene_name": "Ccnd1", "organism": "Rat", "refseq_name": "G1/S-specific cyclin-D1", "refseq_ac": [ { "id": "NP_741989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741989", "type": "external" } ], "gene_names_uniprotkb": "Ccnd1", "gene_names_refseq": "Ccnd1", "protein_names_uniprotkb": "G1/S-specific cyclin-D1", "protein_names_refseq": "G1/S-specific cyclin-D1", "tax_id": 10116, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon adenoma (Disease Ontology:DOID:0050912); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); penile benign neoplasm (Disease Ontology:DOID:11624); interstitial cystitis (Disease Ontology:DOID:13949); von Hippel-Lindau disease (Disease Ontology:DOID:14175); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); transitional cell carcinoma (Disease Ontology:DOID:2671); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); invasive lobular carcinoma (Disease Ontology:DOID:3457); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cancer (Disease Ontology:DOID:3571); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); lung small cell carcinoma (Disease Ontology:DOID:5409); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pancreatic solid pseudopapillary carcinoma (Disease Ontology:DOID:6827); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:58919); (R-RNO-187577); (R-RNO-3214858); (R-RNO-69231); (R-RNO-75815); (R-RNO-8849470); (R-RNO-8934593); (R-RNO-8951936); (R-RNO-9754119); (R-RNO-9929491)", "pathway_count": 10, "publication_count": 7, "publication_id_list": "10910956;24231000;33811247;34309628;37684532;7980531;8336937", "class_list": "", "function": "Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1., [RefSeq, PubMed]; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner., [UniProtKB, UniProtKB]; Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P39948-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39949-1", "uniprot_id": [ { "id": "CCNE1_RAT", "url": "https://www.uniprot.org/uniprot/P39949", "type": "external" } ], "mass": 47482.0, "length": 411, "protein_name": "G1/S-specific cyclin-E1", "gene_name": "Ccne1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccne1; Ccne", "gene_names_refseq": "", "protein_names_uniprotkb": "G1/S-specific cyclin-E1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 15 (Disease Ontology:DOID:0070500); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); breast adenocarcinoma (Disease Ontology:DOID:3458); liver cancer (Disease Ontology:DOID:3571); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (R-RNO-1538133); (R-RNO-187577); (R-RNO-2559586); (R-RNO-6804116); (R-RNO-69017); (R-RNO-69200); (R-RNO-69202); (R-RNO-69231); (R-RNO-69563); (R-RNO-8849470); (R-RNO-9706019)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "8336937;8673024", "class_list": "", "function": "Essential for the control of the cell cycle at the G1/S (start) transition., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09138", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0016301 kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0001547 antral ovarian follicle growth;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P39949-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39950-1", "uniprot_id": [ { "id": "CCNG1_RAT", "url": "https://www.uniprot.org/uniprot/P39950", "type": "external" } ], "mass": 33934.0, "length": 294, "protein_name": "Cyclin-G1", "gene_name": "Ccng1", "organism": "Rat", "refseq_name": "cyclin-G1", "refseq_ac": [ { "id": "NP_037055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037055", "type": "external" } ], "gene_names_uniprotkb": "Ccng1; Ccng", "gene_names_refseq": "CYCG; Ccng1; Ccng", "protein_names_uniprotkb": "Cyclin-G1; Cyclin-G", "protein_names_refseq": "cyclin-G1; cyclin-G", "tax_id": 10116, "disease": "aceruloplasminemia (Disease Ontology:DOID:0050711); ovarian serous carcinoma (Disease Ontology:DOID:0050933); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); heart disease (Disease Ontology:DOID:114); head and neck cancer (Disease Ontology:DOID:11934); hemosiderosis (Disease Ontology:DOID:12119); leiomyoma (Disease Ontology:DOID:127); lung cancer (Disease Ontology:DOID:1324); cholestasis (Disease Ontology:DOID:13580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); ovary epithelial cancer (Disease Ontology:DOID:2152); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); localized osteosarcoma (Disease Ontology:DOID:3356); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); brain edema (Disease Ontology:DOID:4724); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); hyperthyroidism (Disease Ontology:DOID:7998); Wilson disease (Disease Ontology:DOID:893); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25405); (R-RNO-6804757)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "7784084;8336937;8954786;9464250", "class_list": "", "function": "May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006949 syncytium formation;GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P39950-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40241-1", "uniprot_id": [ { "id": "CD9_RAT", "url": "https://www.uniprot.org/uniprot/P40241", "type": "external" } ], "mass": 25215.0, "length": 226, "protein_name": "CD9 antigen", "gene_name": "Cd9", "organism": "Rat", "refseq_name": "CD9 antigen", "refseq_ac": [ { "id": "NP_444177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444177", "type": "external" } ], "gene_names_uniprotkb": "Cd9", "gene_names_refseq": "Cd9", "protein_names_uniprotkb": "CD9 antigen", "protein_names_refseq": "CD9 antigen (p24); CD9 antigen", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); severe acute respiratory syndrome (Disease Ontology:DOID:2945); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:24936); (R-RNO-114608); (R-RNO-1300645)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "32830152;34185148;37778977;7823164", "class_list": "", "function": "CD9-positive cells in the intermediate lobe migrate into the anterior lobe to supply endocrine cells., [RefSeq, PubMed]; Expression and functions of cluster of differentiation 9 and 81 in rat mammary epithelial cells., [RefSeq, PubMed]; Fluctuation of CD9/SOX2-positive cell populations during the turnover of GH- and TSH-producing cells in the adult anterior pituitary gland., [RefSeq, PubMed]; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (By similarity). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (By similarity). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008285 negative regulation of cell population proliferation;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P40241-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43165-1", "uniprot_id": [ { "id": "CAH5A_RAT", "url": "https://www.uniprot.org/uniprot/P43165", "type": "external" } ], "mass": 34499.0, "length": 304, "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "Ca5a", "organism": "Rat", "refseq_name": "carbonic anhydrase 5A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_062166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062166", "type": "external" } ], "gene_names_uniprotkb": "Ca5a; Ca5", "gene_names_refseq": "Ca5a; Ca5; Car5a", "protein_names_uniprotkb": "Carbonic anhydrase 5A, mitochondrial; 4.2.1.1; CA-VA; Carbonate dehydratase VA; Carbonic anhydrase VA", "protein_names_refseq": "CA-VA; carbonate dehydratase VA; carbonic anhydrase 5 mitochondrial; carbonic anhydrase 5A, mitochondrial precursor; carbonic anhydrase 5a, mitochondrial; carbonic anhydrase Va, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:54233); (R-RNO-1475029)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7937950", "class_list": "", "function": "Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:7937950). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P43165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45953-1", "uniprot_id": [ { "id": "ACADV_RAT", "url": "https://www.uniprot.org/uniprot/P45953", "type": "external" } ], "mass": 70749.0, "length": 655, "protein_name": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadvl", "organism": "Rat", "refseq_name": "very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_037023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037023", "type": "external" } ], "gene_names_uniprotkb": "Acadvl", "gene_names_refseq": "Acadvl; VLCAD", "protein_names_uniprotkb": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.8; 1.3.8.9; Long-chain specific acyl-CoA dehydrogenase, mitochondrial; VLCAD", "protein_names_refseq": "VLCAD very-long-chain acyl-CoA dehydrogenase; Very long chain Acyl-Coa dehydrogenase; acyl-Coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "very long chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080155); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:25363); (R-RNO-77305)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1730632;26446791;34502162;8034667", "class_list": "", "function": "Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production) (By similarity) (PubMed:1730632, PubMed:8034667). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains, but can also catalyze monounsaturated fatty acids such as oleate ((9Z)-octadecenoate), (9Z)-hexadecenoate, and others (By similarity) (PubMed:1730632, PubMed:8034667). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACAD9 and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0006635 fatty acid beta-oxidation;GO:0009062 fatty acid catabolic process;GO:0009409 response to cold;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P45953-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47864-1", "uniprot_id": [ { "id": "AQP5_RAT", "url": "https://www.uniprot.org/uniprot/P47864", "type": "external" } ], "mass": 28421.0, "length": 265, "protein_name": "Aquaporin-5", "gene_name": "Aqp5", "organism": "Rat", "refseq_name": "aquaporin-5", "refseq_ac": [ { "id": "NP_036911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036911", "type": "external" } ], "gene_names_uniprotkb": "Aqp5", "gene_names_refseq": "Aqp5", "protein_names_uniprotkb": "Aquaporin-5; AQP-5", "protein_names_refseq": "AQP-5; aquaporin-5", "tax_id": 10116, "disease": "Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); dry eye syndrome (Disease Ontology:DOID:10140); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:25241); (R-RNO-432047)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "33840298;35324416;36210422;37005283;38453769;7530250;8621489", "class_list": "", "function": "Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:7530250, PubMed:8621489). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Evaluation of the Content of Aquaporin-5 and Epithelial Sodium Channel in the Lungs of Rats during the Development of Toxic Pulmonary Edema Caused by Intoxication with Acylating Pulmonotoxicants., [RefSeq, PubMed]; FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland., [RefSeq, PubMed]; Role of aquaporin 5 and glandular blood flow in the acetylcholine-induced secretion of saliva in rats., [RefSeq, PubMed]; Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats., [RefSeq, PubMed]; Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDV0;Q569C5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005902 microvillus", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0046541 saliva secretion;GO:0051289 protein homotetramerization;GO:0030157 pancreatic juice secretion;GO:0042476 odontogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47864-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49088-1", "uniprot_id": [ { "id": "ASNS_RAT", "url": "https://www.uniprot.org/uniprot/P49088", "type": "external" } ], "mass": 64247.0, "length": 561, "protein_name": "Asparagine synthetase [glutamine-hydrolyzing]", "gene_name": "Asns", "organism": "Rat", "refseq_name": "asparagine synthetase [glutamine-hydrolyzing]", "refseq_ac": [ { "id": "NP_037211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037211", "type": "external" } ], "gene_names_uniprotkb": "Asns", "gene_names_refseq": "Asns", "protein_names_uniprotkb": "Asparagine synthetase [glutamine-hydrolyzing]; 6.3.5.4; Glutamine-dependent asparagine synthetase", "protein_names_refseq": "asparagine synthetase [glutamine-hydrolyzing]; glutamine-dependent asparagine synthetase", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25612); (R-RNO-8963693)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7818476", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HR8", "ec_number_list": [ { "id": "6.3.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle;GO:0031667 response to nutrient levels;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49088-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49620-1", "uniprot_id": [ { "id": "DGKG_RAT", "url": "https://www.uniprot.org/uniprot/P49620", "type": "external" } ], "mass": 88521.0, "length": 788, "protein_name": "Diacylglycerol kinase gamma", "gene_name": "Dgkg", "organism": "Rat", "refseq_name": "diacylglycerol kinase gamma", "refseq_ac": [ { "id": "NP_037258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037258", "type": "external" } ], "gene_names_uniprotkb": "Dgkg; Dagk3", "gene_names_refseq": "DGK-III; DGKIII; Dagk3; Dgkg", "protein_names_uniprotkb": "Diacylglycerol kinase gamma; 2.7.1.107; 88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-III; DGK-gamma; Diglyceride kinase gamma", "protein_names_refseq": "88 kDa diacylglycerol kinase; DAG kinase gamma; DGK-gamma; Diacylglycerol kinase 3 (gamma); diacylglycerol kinase gamma; diglyceride kinase gamma", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25666); (R-RNO-114508)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16019106;16905533;24513282;33563877;7809169", "class_list": "", "function": "Cellular expression and subcellular localization of diacylglycerol kinase gamma in rat brain., [RefSeq, PubMed]; Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7809169). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In brain, DGKgamma showed sustained expression throughout the postnatal developmental periods. And In the hippocampal pyramidal cell, Dgkg localized in the cytosol., [RefSeq, PubMed]; Knockdown of Dgkg, but not DGK-alpha, inhibited degranulation in mast cells., [RefSeq, PubMed]; Localization and activation of the functionally correlated kinases, gammaPKC and DGKgamma, are spatio-temporally orchestrated by their direct association and phosphorylation, contributing to subtype-specific regulation of DGKgamma and DAG signaling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49620-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50229-1", "uniprot_id": [ { "id": "CCL3_RAT", "url": "https://www.uniprot.org/uniprot/P50229", "type": "external" } ], "mass": 10335.0, "length": 92, "protein_name": "C-C motif chemokine 3", "gene_name": "Ccl3", "organism": "Rat", "refseq_name": "C-C motif chemokine 3 precursor", "refseq_ac": [ { "id": "NP_037157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037157", "type": "external" } ], "gene_names_uniprotkb": "Ccl3; Mip1a; Scya3", "gene_names_refseq": "Ccl3; MIP-1a; Scya3", "protein_names_uniprotkb": "C-C motif chemokine 3; MIP-1-alpha; Macrophage inflammatory protein 1-alpha; Small-inducible cytokine A3", "protein_names_refseq": "C-C motif chemokine 3 precursor; C-C motif chemokine 3; MIP-1-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); chemokine (C-C motif) ligand 3; macrophage inflammatory protein 1-alpha; small-inducible cytokine A3", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); COVID-19 (Disease Ontology:DOID:0080600); nephritis (Disease Ontology:DOID:10952); Chagas disease (Disease Ontology:DOID:12140); alcoholic hepatitis (Disease Ontology:DOID:12351); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); crescentic glomerulonephritis (Disease Ontology:DOID:13139); erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271); anterior uveitis (Disease Ontology:DOID:1407); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); acute kidney failure (Disease Ontology:DOID:3021); systemic scleroderma (Disease Ontology:DOID:418); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:25542); (R-RNO-380108)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17218081;32306124;7722328;7779098;8607872", "class_list": "", "function": "MiR-21 protects neonatal rats from hypoxic-ischemic brain damage by targeting CCL3., [RefSeq, PubMed]; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1EC87", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50229-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50298-1", "uniprot_id": [ { "id": "ARY2_RAT", "url": "https://www.uniprot.org/uniprot/P50298", "type": "external" } ], "mass": 33756.0, "length": 290, "protein_name": "Arylamine N-acetyltransferase 2", "gene_name": "Nat2", "organism": "Rat", "refseq_name": "arylamine N-acetyltransferase 2", "refseq_ac": [ { "id": "NP_446306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446306", "type": "external" } ], "gene_names_uniprotkb": "Nat2; Aac2", "gene_names_refseq": "Nat2a; Nat2", "protein_names_uniprotkb": "Arylamine N-acetyltransferase 2; 2.3.1.118; 2.3.1.5; AT-2; Arylamide acetylase 2; N-acetyltransferase type 2; N-hydroxyarylamine O-acetyltransferase; NAT-2", "protein_names_refseq": "AT-2; N-Acetyltransferase-2 (arylamine N-acetyltransferase); N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; N-hydroxyarylamine O-acetyltransferase; NAT-2; arylamide acetylase 2; arylamine N-acetyltransferase 2", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); leukemia (Disease Ontology:DOID:1240); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); pulmonary tuberculosis (Disease Ontology:DOID:2957); adenocarcinoma (Disease Ontology:DOID:299); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); occupational dermatitis (Disease Ontology:DOID:4404); cholangiocarcinoma (Disease Ontology:DOID:4947); progressive supranuclear palsy (Disease Ontology:DOID:678); end stage renal disease (Disease Ontology:DOID:783); lung disease (Disease Ontology:DOID:850); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:116632); (R-RNO-156582); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24557547;28359264;7882993;8528272;8761433", "class_list": "", "function": "Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates. Participates in the detoxification of a plethora of hydrazine and arylamine drugs., [UniProtKB, PubMed, PubMed]; High NAT2 expression is associated with mammary tumor susceptibility. Publication Status: Online-Only, [RefSeq, PubMed]; High-altitude hypoxia decreases the activity and expression of CYP1A1 and NAT2, but increases that of CYP2D6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.5", "type": "external" }, { "id": "2.3.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.118", "type": "external" } ], "go_molecular_function": "GO:0004060 arylamine N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity;GO:0046990 N-hydroxyarylamine O-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0048565 digestive tract development;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50339-1", "uniprot_id": [ { "id": "CMA1_RAT", "url": "https://www.uniprot.org/uniprot/P50339", "type": "external" } ], "mass": 27569.0, "length": 247, "protein_name": "Chymase", "gene_name": "Cma1", "organism": "Rat", "refseq_name": "chymase precursor", "refseq_ac": [ { "id": "NP_037224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037224", "type": "external" } ], "gene_names_uniprotkb": "Cma1; Mcpt3", "gene_names_refseq": "Cma1; MCP3P; Mcpt5", "protein_names_uniprotkb": "Chymase; 3.4.21.39; Alpha-chymase; Mast cell protease 3; Mast cell protease 5; Mast cell protease III; rMCP-3; rMCP-5; rMCP-III", "protein_names_refseq": "alpha-chymase; chymase 1, mast cell; chymase precursor; mast cell protease 3; mast cell protease 5; mast cell protease III; rMCP-3; rMCP-5; rMCP-III", "tax_id": 10116, "disease": "sarcoidosis (Disease Ontology:DOID:11335); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); renovascular hypertension (Disease Ontology:DOID:1591); congenital heart disease (Disease Ontology:DOID:1682); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:25627); (R-RNO-1433557); (R-RNO-1592389); (R-RNO-2022377)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "27465904;28748720;31036322;7487912;8996238", "class_list": "", "function": "Chymase activity in synovial fluids of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway., [RefSeq, PubMed]; Compared to chymase, ACE-mediated angiotensin-(1-12) metabolism in the heart was several fold lower. Overall our findings suggest that angiotensin-(1-12), not Ang I, is the better substrate for Ang II formation by chymase in adult rats., [RefSeq, PubMed]; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion., [UniProtKB]; The pathobiologic response in WKY rats was directly linked to increases in cardiac gene expression and enzymatic activity of chymase and modest reductions in ACE2 activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R2C8", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042277 peptide binding;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0016485 protein processing;GO:0022617 extracellular matrix disassembly;GO:0071333 cellular response to glucose stimulus;GO:0045766 positive regulation of angiogenesis;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50339-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51556-1", "uniprot_id": [ { "id": "DGKA_RAT", "url": "https://www.uniprot.org/uniprot/P51556", "type": "external" } ], "mass": 82199.0, "length": 727, "protein_name": "Diacylglycerol kinase alpha", "gene_name": "Dgka", "organism": "Rat", "refseq_name": "diacylglycerol kinase alpha", "refseq_ac": [ { "id": "NP_542965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542965", "type": "external" } ], "gene_names_uniprotkb": "Dgka; Dagk1; Dagk", "gene_names_refseq": "Dagk1; Dgka", "protein_names_uniprotkb": "Diacylglycerol kinase alpha; 2.7.1.107; 2.7.1.93; 80 kDa diacylglycerol kinase; DAG kinase alpha; DGK-alpha; Diglyceride kinase alpha", "protein_names_refseq": "80 kDa diacylglycerol kinase; DAG kinase alpha; DGK-alpha; diacylglycerol kinase alpha; diglyceride kinase alpha", "tax_id": 10116, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:140866); (R-RNO-114508)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1339302;22627129;23467923;34312706", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:22627129). Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (By similarity). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The DGKalpha localize predominantly to the nucleus of ganglion cells., [RefSeq, PubMed]; The expression of diacylglycerol kinase isoforms alpha and zeta correlates with the progression of experimental autoimmune encephalomyelitis in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51556-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51646-1", "uniprot_id": [ { "id": "ARL5A_RAT", "url": "https://www.uniprot.org/uniprot/P51646", "type": "external" } ], "mass": 20714.0, "length": 179, "protein_name": "ADP-ribosylation factor-like protein 5A", "gene_name": "Arl5a", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 5A", "refseq_ac": [ { "id": "NP_446431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446431", "type": "external" } ], "gene_names_uniprotkb": "Arl5a; Arl5", "gene_names_refseq": "Arl5a; Arl5", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 5A", "protein_names_refseq": "ADP-ribosylation factor like GTPase 5A; ADP-ribosylation factor-like 5A; ADP-ribosylation factor-like 5; ADP-ribosylation factor-like protein 5A", "tax_id": 10116, "disease": "", "pathway": " (rno:117050)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8765741", "class_list": "", "function": "Lacks ADP-ribosylation enhancing activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8N2", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51646-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53369-1", "uniprot_id": [ { "id": "8ODP_RAT", "url": "https://www.uniprot.org/uniprot/P53369", "type": "external" } ], "mass": 18018.0, "length": 156, "protein_name": "Oxidized purine nucleoside triphosphate hydrolase", "gene_name": "Nudt1", "organism": "Rat", "refseq_name": "oxidized purine nucleoside triphosphate hydrolase", "refseq_ac": [ { "id": "NP_476461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476461", "type": "external" } ], "gene_names_uniprotkb": "Nudt1; Mth1", "gene_names_refseq": "Mth1; Nudt1", "protein_names_uniprotkb": "Oxidized purine nucleoside triphosphate hydrolase; 2-hydroxy-dATP diphosphatase; 3.6.1.-; 3.6.1.56; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; Methylated purine nucleoside triphosphate hydrolase; Nucleoside diphosphate-linked moiety X motif 1; Nudix motif 1", "protein_names_refseq": "2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; methylated purine nucleoside triphosphate hydrolase; mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1; nudix-type motif 1; oxidized purine nucleoside triphosphate hydrolase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:117260); (R-RNO-2393930)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11817101;28261604;30304478;32144205;33021405;7586133", "class_list": "", "function": "MTH1 is downregulated by HS-1200, which inhibits hepatocarcinogenesis and improves liver function, [RefSeq, PubMed]; Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension., [RefSeq, PubMed]; Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:7586133). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:7586133). Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (By similarity). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:7586133). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:30304478, PubMed:32144205, PubMed:7586133)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0030515 snoRNA binding;GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0047693 ATP diphosphatase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008584 male gonad development;GO:0042262 DNA protection;GO:0046686 response to cadmium ion;GO:0006152 purine nucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P53369-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54690-1", "uniprot_id": [ { "id": "BCAT1_RAT", "url": "https://www.uniprot.org/uniprot/P54690", "type": "external" } ], "mass": 46046.0, "length": 411, "protein_name": "Branched-chain-amino-acid aminotransferase, cytosolic", "gene_name": "Bcat1", "organism": "Rat", "refseq_name": "branched-chain-amino-acid aminotransferase, cytosolic isoform 1", "refseq_ac": [ { "id": "NP_058949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058949", "type": "external" } ], "gene_names_uniprotkb": "Bcat1", "gene_names_refseq": "Bcat1; Bcatc", "protein_names_uniprotkb": "Branched-chain-amino-acid aminotransferase, cytosolic; 2.6.1.42; BCAT(c)", "protein_names_refseq": "BCAT(c); branched chain amino acid transaminase 1, cytosolic; branched chain aminotransferase 1, cytosolic; branched-chain-amino-acid aminotransferase, cytosolic isoform 1; branched-chain-amino-acid aminotransferase, cytosolic", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pigment dispersion syndrome (Disease Ontology:DOID:0060680); gastric ulcer (Disease Ontology:DOID:10808); dilated cardiomyopathy (Disease Ontology:DOID:12930); primary angle-closure glaucoma (Disease Ontology:DOID:1405); myopathy (Disease Ontology:DOID:423); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial myopathy (Disease Ontology:DOID:699); ulcerative colitis (Disease Ontology:DOID:8577); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:29592); (R-RNO-70895)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17348860;38871197;8381418;8530459", "class_list": "", "function": "BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage., [RefSeq, PubMed]; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This metabolic enzyme is expressed throughout the brain and spinal cord, with distinct differences in regional and intracellular patterns of expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.42", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004084 branched-chain-amino-acid transaminase activity;GO:0052654 L-leucine-2-oxoglutarate transaminase activity;GO:0052655 L-valine-2-oxoglutarate transaminase activity;GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009083 branched-chain amino acid catabolic process;GO:0009098 L-leucine biosynthetic process;GO:0009099 L-valine biosynthetic process;GO:0008652 amino acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54690-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55213-1", "uniprot_id": [ { "id": "CASP3_RAT", "url": "https://www.uniprot.org/uniprot/P55213", "type": "external" } ], "mass": 31492.0, "length": 277, "protein_name": "Caspase-3", "gene_name": "Casp3", "organism": "Rat", "refseq_name": "caspase-3", "refseq_ac": [ { "id": "NP_037054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037054", "type": "external" } ], "gene_names_uniprotkb": "Casp3; Cpp32", "gene_names_refseq": "CPP32-beta; Casp3; Lice; Yama", "protein_names_uniprotkb": "Caspase-3; 3.4.22.56; Apopain; CASP-3; CPP-32; Cysteine protease CPP32; IRP; LICE; Protein Yama; SCA-1; SREBP cleavage activity 1", "protein_names_refseq": "CASP-3; CPP-32; CPP32beta; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); IRP; SCA-1; SREBP cleavage activity 1; apopain; caspase-3; cysteine protease CPP32; cysteine protease p32-beta; protein Yama", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); traumatic brain injury (Disease Ontology:DOID:0081292); endometritis (Disease Ontology:DOID:1002); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); cryptorchidism (Disease Ontology:DOID:11383); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); spermatic cord torsion (Disease Ontology:DOID:11996); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); transitional cell carcinoma (Disease Ontology:DOID:2671); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); intestinal disease (Disease Ontology:DOID:5295); kidney disease (Disease Ontology:DOID:557); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25402); (R-RNO-111459); (R-RNO-111465); (R-RNO-111469); (R-RNO-140342); (R-RNO-2028269); (R-RNO-205025); (R-RNO-264870); (R-RNO-351906); (R-RNO-418889); (R-RNO-449836); (R-RNO-5620971)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "37938347;37955688;38254051;38375595;38396011;7588240;8761296;9030616", "class_list": "", "function": "A novel interaction between aquaporin 1 and caspase-3 in pulmonary arterial smooth muscle cells., [RefSeq, PubMed]; Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling., [RefSeq, PubMed]; Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life., [RefSeq, PubMed]; Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of active caspase 3 in the rat lens after in vivo exposure to subthreshold dose of UVR-B. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively). Cleaves and inactivates interleukin-18 (IL18). Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Also involved in axon pruning during brain development (By similarity). Cleaves DSG2 in response to apoptosis resulting in a loss of full length DSG2 at desmosome cell junctions and subsequent loss of cell-cell adhesion (By similarity). Also cleaves JUP in response to apoptosis (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 57, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70543;P97699;Q62993", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0008047 enzyme activator activity;GO:0044877 protein-containing complex binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006508 proteolysis;GO:0007507 heart development;GO:0007611 learning or memory;GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55213-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55260-1", "uniprot_id": [ { "id": "ANXA4_RAT", "url": "https://www.uniprot.org/uniprot/P55260", "type": "external" } ], "mass": 35849.0, "length": 319, "protein_name": "Annexin A4", "gene_name": "Anxa4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Anxa4; Anx4", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin A4; 36 kDa zymogen granule membrane-associated protein; Annexin IV; Annexin-4; Lipocortin IV; ZAP36", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "12020832;18047804", "class_list": "", "function": "Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031965 nuclear membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0030855 epithelial cell differentiation;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55260-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55281-1", "uniprot_id": [ { "id": "CAD17_RAT", "url": "https://www.uniprot.org/uniprot/P55281", "type": "external" } ], "mass": 91863.0, "length": 827, "protein_name": "Cadherin-17", "gene_name": "Cdh17", "organism": "Rat", "refseq_name": "cadherin-17 precursor", "refseq_ac": [ { "id": "NP_446429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446429", "type": "external" } ], "gene_names_uniprotkb": "Cdh17", "gene_names_refseq": "Cdh17", "protein_names_uniprotkb": "Cadherin-17; LI-cadherin; Liver-intestine cadherin", "protein_names_refseq": "LI-cadherin; cadherin-17 precursor; liver-intestine cadherin", "tax_id": 10116, "disease": "", "pathway": " (rno:117048); (R-RNO-418990)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8207063", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0002314 germinal center B cell differentiation;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55281-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55314-1", "uniprot_id": [ { "id": "CO8B_RAT", "url": "https://www.uniprot.org/uniprot/P55314", "type": "external" } ], "mass": 66667.0, "length": 589, "protein_name": "Complement component C8 beta chain", "gene_name": "C8b", "organism": "Rat", "refseq_name": "complement component C8 beta chain precursor", "refseq_ac": [ { "id": "NP_001178688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178688", "type": "external" } ], "gene_names_uniprotkb": "C8b", "gene_names_refseq": "C8b", "protein_names_uniprotkb": "Complement component C8 beta chain; Complement component 8 subunit beta", "protein_names_refseq": "complement component 8 subunit beta; complement component 8, beta polypeptide; complement component 8, beta subunit; complement component C8 beta chain precursor; complement component C8 beta chain", "tax_id": 10116, "disease": "type II complement component 8 deficiency (Disease Ontology:DOID:0060302); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:313421)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21454685;7665162", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 4, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5EB58", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0006957 complement activation, alternative pathway;GO:0160257 complement activation, GZMK pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55314-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010101.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55797-1", "uniprot_id": [ { "id": "APOC4_RAT", "url": "https://www.uniprot.org/uniprot/P55797", "type": "external" } ], "mass": 14532.0, "length": 124, "protein_name": "Apolipoprotein C-IV", "gene_name": "Apoc4", "organism": "Rat", "refseq_name": "apolipoprotein C-IV precursor", "refseq_ac": [ { "id": "NP_001102889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102889", "type": "external" } ], "gene_names_uniprotkb": "Apoc4; Ecl", "gene_names_refseq": "Acl; Apoc4", "protein_names_uniprotkb": "Apolipoprotein C-IV; Apo-CIV; ApoC-IV; Apolipoprotein C4; Apolipoprotein E-linked; ECL", "protein_names_refseq": "ECL; apo-CIV; apoC-IV; apolipoprotein C-IV precursor; apolipoprotein C-IV; apolipoprotein C2 linked; apolipoprotein CIV; apolipoprotein E-linked", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:680551); (R-RNO-8866423); (R-RNO-8964046)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "1379790", "class_list": "", "function": "May participate in lipoprotein metabolism., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:0006869 lipid transport;GO:0070328 triglyceride homeostasis;GO:0019915 lipid storage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55797-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56522-1", "uniprot_id": [ { "id": "ADRO_RAT", "url": "https://www.uniprot.org/uniprot/P56522", "type": "external" } ], "mass": 54363.0, "length": 494, "protein_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial", "gene_name": "Fdxr", "organism": "Rat", "refseq_name": "NADPH:adrenodoxin oxidoreductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077067", "type": "external" } ], "gene_names_uniprotkb": "Fdxr", "gene_names_refseq": "AR; Fdxr", "protein_names_uniprotkb": "NADPH:adrenodoxin oxidoreductase, mitochondrial; 1.18.1.6; AR; Adrenodoxin reductase; Ferredoxin reductase; Ferredoxin--NADP(+) reductase", "protein_names_refseq": "NADPH:adrenodoxin oxidoreductase, mitochondrial precursor; NADPH:adrenodoxin oxidoreductase, mitochondrial; adrenodoxin reductase; ferredoxin--NADP(+) reductase", "tax_id": 10116, "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Parkinson's disease (Disease Ontology:DOID:14330); auditory system disease (Disease Ontology:DOID:2742); optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (rno:79122); (R-RNO-196108); (R-RNO-211976); (R-RNO-2395516)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10525147;16641100;2170421", "class_list": "", "function": "Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (PubMed:10525147). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.6", "type": "external" }, { "id": "1.18.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.18.1.6", "type": "external" } ], "go_molecular_function": "GO:0004324 ferredoxin-NADP+ reductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56522-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56627-1", "uniprot_id": [ { "id": "AQP9_RAT", "url": "https://www.uniprot.org/uniprot/P56627", "type": "external" } ], "mass": 31871.0, "length": 295, "protein_name": "Aquaporin-9", "gene_name": "Aqp9", "organism": "Rat", "refseq_name": "aquaporin-9", "refseq_ac": [ { "id": "NP_075249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075249", "type": "external" } ], "gene_names_uniprotkb": "Aqp9; Aqp9l", "gene_names_refseq": "Aqp9", "protein_names_uniprotkb": "Aquaporin-9; AQP-9; Aquaglyceroporin-9", "protein_names_refseq": "AQP-9; aquaglyceroporin-9; aquaporin-9; neutral solute channel aquaporin 9", "tax_id": 10116, "disease": "", "pathway": " (rno:65054); (R-RNO-432030); (R-RNO-432047)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10205677;11972053;15988592;30266683;31218464;31533210;31746418;9733774", "class_list": "", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10205677, PubMed:9733774). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:9733774). AQP9 may also facilitate hepatic urea extrusion. Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy. Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:11972053). It is also permeable to H2O2 in vivo (By similarity). Could also be permeable to ammonium (PubMed:15988592)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer's disease models in vitro and in vivo., [RefSeq, PubMed]; LncRNA MALAT1 promotes neuropathic pain progression through the miR1545p/AQP9 axis in CCI rat models., [RefSeq, PubMed]; The combination of AQP9 gene knock-down and U0126 showed no further effect. Silencing AQP9 gene can inhibit the activation of ERK1/2 signaling pathway, attenuate the inflammatory response in rats with MI, inhibit apoptosis of myocardial cells, and improve cardiac function, [RefSeq, PubMed]; The maternal low-protein diet decreased AQP9 and VEGFr-2 expression, decreased epididymal microvascularity and altered the morphometric features of the epididymal epithelium. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88815", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015265 urea channel activity;GO:0005345 purine nucleobase transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0006970 response to osmotic stress;GO:0071320 cellular response to cAMP;GO:0015722 canalicular bile acid transport;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56745-1", "uniprot_id": [ { "id": "CLD1_RAT", "url": "https://www.uniprot.org/uniprot/P56745", "type": "external" } ], "mass": 22843.0, "length": 211, "protein_name": "Claudin-1", "gene_name": "Cldn1", "organism": "Rat", "refseq_name": "claudin-1", "refseq_ac": [ { "id": "NP_113887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113887", "type": "external" } ], "gene_names_uniprotkb": "Cldn1", "gene_names_refseq": "Cldn1", "protein_names_uniprotkb": "Claudin-1", "protein_names_refseq": "claudin-1", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); atopic dermatitis (Disease Ontology:DOID:3310); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); periodontitis (Disease Ontology:DOID:824); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:65129)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11159859;15051488;34018017;34789399;35370461;37277581", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity)., [UniProtKB]; EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in PPI-refractory gastroesophageal reflux disease., [RefSeq, PubMed]; MiR-3571 modulates the proliferation and migration of vascular smooth muscle cells by targeting claudin 1. Publication Status: Online-Only, [RefSeq, PubMed]; Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy., [RefSeq, PubMed]; Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6V9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol;GO:0051259 protein complex oligomerization;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56745-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58428-3", "uniprot_id": [ { "id": "ABCG8_RAT", "url": "https://www.uniprot.org/uniprot/P58428", "type": "external" } ], "mass": 78236.0, "length": 694, "protein_name": "ATP-binding cassette sub-family G member 8", "gene_name": "Abcg8", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family G member 8", "refseq_ac": [ { "id": "NP_569098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569098", "type": "external" } ], "gene_names_uniprotkb": "Abcg8", "gene_names_refseq": "Abcg8", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 8; 7.6.2.-; Sterolin-2", "protein_names_refseq": "ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G (WHITE), member 8; sterolin 2", "tax_id": 10116, "disease": "sitosterolemia 1 (Disease Ontology:DOID:0070634); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sitosterolemia (Disease Ontology:DOID:0090019); familial hyperlipidemia (Disease Ontology:DOID:1168); cholestasis (Disease Ontology:DOID:13580); arteriosclerosis (Disease Ontology:DOID:2349); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:155192); (R-RNO-1369062)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11452359;12783625;25912874", "class_list": "", "function": "ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity., [UniProtKB, UniProtKB]; In contrast, the marked reduction of hepatic Abcg5/8 observed is an effect of the high sugar content of the diets., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIQ5;Q923R7", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0055085 transmembrane transport;GO:0031667 response to nutrient levels;GO:0010949 negative regulation of intestinal phytosterol absorption;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58428-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58821-1", "uniprot_id": [ { "id": "CALY_RAT", "url": "https://www.uniprot.org/uniprot/P58821", "type": "external" } ], "mass": 24718.0, "length": 226, "protein_name": "Neuron-specific vesicular protein calcyon", "gene_name": "Caly", "organism": "Rat", "refseq_name": "neuron-specific vesicular protein calcyon", "refseq_ac": [ { "id": "NP_001177328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177328", "type": "external" } ], "gene_names_uniprotkb": "Caly; Drd1ip", "gene_names_refseq": "Calcyon; Caly; Drd1ip", "protein_names_uniprotkb": "Neuron-specific vesicular protein calcyon", "protein_names_refseq": "D1 dopamine receptor-interacting protein; calcyon; dopamine receptor D1 interacting protein; neuron-specific vesicular protein calcyon", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:192349)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11920718;16595675;17623072;17885599;22843680;28734834;29949458", "class_list": "", "function": "Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization, [RefSeq, PubMed]; Caly is a multifunctional scaffolding protein that regulates axonal transport of late endosomes and lysosome-related organelles by coordinately interacting with motor and vesicle coat proteins., [RefSeq, PubMed]; Endocytic and cargo sorting functions of Caly in neurons, [RefSeq, PubMed]; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0016197 endosomal transport;GO:0008089 anterograde axonal transport;GO:0048268 clathrin coat assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P58821-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60486-1", "uniprot_id": [ { "id": "DAZP2_RAT", "url": "https://www.uniprot.org/uniprot/P60486", "type": "external" } ], "mass": 17292.0, "length": 168, "protein_name": "DAZ-associated protein 2", "gene_name": "Dazap2", "organism": "Rat", "refseq_name": "DAZ-associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001382601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382601", "type": "external" } ], "gene_names_uniprotkb": "Dazap2; Prtb", "gene_names_refseq": "Dazap2", "protein_names_uniprotkb": "DAZ-associated protein 2; Deleted in azoospermia-associated protein 2; Proline-rich transcript in brain protein", "protein_names_refseq": "DAZ-associated protein 2 isoform 1; deleted in azoospermia-associated protein 2; proline-rich transcript in brain protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHD1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0050699 WW domain binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0031648 protein destabilization;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P60486-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61214-1", "uniprot_id": [ { "id": "ARL4A_RAT", "url": "https://www.uniprot.org/uniprot/P61214", "type": "external" } ], "mass": 22588.0, "length": 200, "protein_name": "ADP-ribosylation factor-like protein 4A", "gene_name": "Arl4a", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 4A", "refseq_ac": [ { "id": "NP_062059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062059", "type": "external" } ], "gene_names_uniprotkb": "Arl4a; Arl4", "gene_names_refseq": "Arl4a; Arl4", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 4A", "protein_names_refseq": "ADP-ribosylation factor like GTPase 4A; ADP-ribosylation factor-like 4A; ADP-ribosylation factor-like 4; ADP-ribosylation factor-like protein 4A; ADP-ribosylation-like 4", "tax_id": 10116, "disease": "", "pathway": " (rno:29308)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10980193;8195219", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P41275", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0050873 brown fat cell differentiation;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61250-1", "uniprot_id": [ { "id": "CNCG_RAT", "url": "https://www.uniprot.org/uniprot/P61250", "type": "external" } ], "mass": 9044.0, "length": 83, "protein_name": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "Pde6h", "organism": "Rat", "refseq_name": "retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "refseq_ac": [ { "id": "NP_446140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446140", "type": "external" } ], "gene_names_uniprotkb": "Pde6h", "gene_names_refseq": "Pde6g; Pde6h", "protein_names_uniprotkb": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; 3.1.4.35; GMP-PDE gamma", "protein_names_refseq": "GMP-PDE gamma; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase 6H, cGMP-specific, cone, gamma; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "tax_id": 10116, "disease": "achromatopsia 6 (Disease Ontology:DOID:0081025)", "pathway": " (rno:114248)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15494017", "class_list": "", "function": "PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development [review] Review article, [RefSeq, PubMed]; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1Y6;Q9EP63", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61250-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62332-1", "uniprot_id": [ { "id": "ARF6_RAT", "url": "https://www.uniprot.org/uniprot/P62332", "type": "external" } ], "mass": 20082.0, "length": 175, "protein_name": "ADP-ribosylation factor 6", "gene_name": "Arf6", "organism": "Rat", "refseq_name": "ADP-ribosylation factor 6", "refseq_ac": [ { "id": "NP_077066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077066", "type": "external" } ], "gene_names_uniprotkb": "Arf6", "gene_names_refseq": "Arf6", "protein_names_uniprotkb": "ADP-ribosylation factor 6; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor 6", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:79121); (R-RNO-8854214); (R-RNO-8856828); (R-RNO-8875656)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10022920;16672654;26446845;31206670;31907062;8813705", "class_list": "", "function": "GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:26446845). Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:16672654). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes (PubMed:26446845)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; High glucose-induced cholesterol accumulation and cellular injury in podocytes may be related to the recycling disorder of ABCA1 caused by the downexpression of Arf6 in diabetic kidney disease., [RefSeq, PubMed]; The small GTPase ARF6 regulates GABAergic synapse development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P26438;Q5BKA5", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0031996 thioesterase binding;GO:0035591 signaling adaptor activity;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1903438 positive regulation of mitotic cytokinetic process;GO:0001889 liver development;GO:0006886 intracellular protein transport;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62332-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62634-1", "uniprot_id": [ { "id": "CNBP_RAT", "url": "https://www.uniprot.org/uniprot/P62634", "type": "external" } ], "mass": 19463.0, "length": 177, "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "Cnbp", "organism": "Rat", "refseq_name": "CCHC-type zinc finger nucleic acid binding protein", "refseq_ac": [ { "id": "NP_072120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072120", "type": "external" } ], "gene_names_uniprotkb": "Cnbp; Znf9", "gene_names_refseq": "Cnbp1; Cnbp; Znf9", "protein_names_uniprotkb": "CCHC-type zinc finger nucleic acid binding protein; CNBP; Cellular nucleic acid-binding protein; Zinc finger protein 9", "protein_names_refseq": "CCHC-type zinc finger nucleic acid binding protein; cellular nucleic acid binding protein 1; cellular nucleic acid-binding protein; zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)", "tax_id": 10116, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (rno:64530)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14505273;15978772;17335846;20102514;7788528", "class_list": "", "function": "Findings showed that ZNF9 is ubiquitously expressed in mammalian tissues, and that its signal is not substantially modified in myotonic dystrophy type 2 muscles, [RefSeq, PubMed]; Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (By similarity). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (PubMed:7788528). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20694;Q5QJQ8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding;GO:0045182 translation regulator activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62775-1", "uniprot_id": [ { "id": "MTPN_RAT", "url": "https://www.uniprot.org/uniprot/P62775", "type": "external" } ], "mass": 12861.0, "length": 118, "protein_name": "Myotrophin", "gene_name": "Mtpn", "organism": "Rat", "refseq_name": "myotrophin", "refseq_ac": [ { "id": "NP_077350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077350", "type": "external" } ], "gene_names_uniprotkb": "Mtpn; Gcdp", "gene_names_refseq": "Gcdp; Mtpn", "protein_names_uniprotkb": "Myotrophin; Granule cell differentiation protein; Protein V-1", "protein_names_refseq": "V-1 protein; granule cell differentiation protein; growth factor; myotrophin; protein V-1; stimulates myocyte growth", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:79215)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15946807;1633812;17041682;17113103;18693253;8144589;8576259;9194197;9634699", "class_list": "", "function": "After internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to stimulate myocyte growth., [RefSeq, PubMed]; Characterisation of the small ankyrin repeat protein myotrophin, [RefSeq, PubMed]; Data strongly suggest that myotrophin appears to be a candidate gene for cardiac hypertrophy and heart failure., [RefSeq, PubMed]; Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity). Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy., [UniProtKB, PubMed, PubMed]; Results suggest that myotrophin V1 is a predominantly cytosolic protein that could regulate the NFkappa-beta mediated transcription process., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P80144;Q58HB3;Q9DCN8", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0010557 positive regulation of macromolecule biosynthetic process;GO:2000812 regulation of barbed-end actin filament capping;GO:0030307 positive regulation of cell growth;GO:0051247 positive regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62775-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62957-1", "uniprot_id": [ { "id": "CCG7_RAT", "url": "https://www.uniprot.org/uniprot/P62957", "type": "external" } ], "mass": 31003.0, "length": 275, "protein_name": "Voltage-dependent calcium channel gamma-7 subunit", "gene_name": "Cacng7", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-7 subunit", "refseq_ac": [ { "id": "NP_542426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542426", "type": "external" } ], "gene_names_uniprotkb": "Cacng7", "gene_names_refseq": "Cacng7", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-7 subunit; Neuronal voltage-gated calcium channel gamma-7 subunit; TARP gamma-7; Transmembrane AMPAR regulatory protein gamma-7", "protein_names_refseq": "TARP gamma-7; calcium channel, voltage-dependent, gamma subunit 7; neuronal voltage-gated calcium channel gamma-7 subunit; transmembrane AMPAR regulatory protein gamma-7; voltage-dependent calcium channel gamma-7 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:140728); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11738816;18817736;19234459;19265014;21127204;22673903", "class_list": "", "function": "Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:18817736, PubMed:19234459). Shows specificity only for GRIA1 and GRIA2 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VBX3;Q8WXS6;Q9BXT1", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0043025 neuronal cell body;GO:0032281 AMPA glutamate receptor complex;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0043488 regulation of mRNA stability;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62957-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63039-1", "uniprot_id": [ { "id": "CH60_RAT", "url": "https://www.uniprot.org/uniprot/P63039", "type": "external" } ], "mass": 60955.0, "length": 573, "protein_name": "60 kDa heat shock protein, mitochondrial", "gene_name": "Hspd1", "organism": "Rat", "refseq_name": "60 kDa heat shock protein, mitochondrial", "refseq_ac": [ { "id": "NP_071565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071565", "type": "external" } ], "gene_names_uniprotkb": "Hspd1; Hsp60", "gene_names_refseq": "Hsp60; Hspd1-30p; Hspd1", "protein_names_uniprotkb": "60 kDa heat shock protein, mitochondrial; 5.6.1.7; 60 kDa chaperonin; CPN60; Chaperonin 60; HSP-60; HSP-65; Heat shock protein 60; Hsp60; Mitochondrial matrix protein P1", "protein_names_refseq": "60 kDa chaperonin; 60 kDa heat shock protein, mitochondrial; CPN60; HSP-60; HSP-65; chaperonin 60; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock protein 1 (chaperonin); heat shock protein 60 (liver); heat shock protein family D member 1; mitochondrial matrix protein P1", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 4 (Disease Ontology:DOID:0060789); hereditary spastic paraplegia 13 (Disease Ontology:DOID:0110766); glucose intolerance (Disease Ontology:DOID:10603); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); varicocele (Disease Ontology:DOID:12337); autistic disorder (Disease Ontology:DOID:12849); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); arteriosclerosis (Disease Ontology:DOID:2349); hereditary spastic paraplegia (Disease Ontology:DOID:2476); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); systemic lupus erythematosus (Disease Ontology:DOID:9074); aphthous stomatitis (Disease Ontology:DOID:9663)", "pathway": " (rno:63868); (R-RNO-1268020); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10882416;14978079;16579988;17082575;18047804;18683930;1976241;1979858;21914624;22673903;26446791;27213235;30196524;30896796;31802366;32892424;33219889;34502162;41549750", "class_list": "", "function": "Abnormal lipid metabolism induced apoptosis of spermatogenic cells by increasing testicular HSP60 protein expression., [RefSeq, PubMed]; Biodistribution and pharmacokinetic profiles of an altered peptide ligand derived from heat-shock proteins 60 in Lewis rats., [RefSeq, PubMed]; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB]; Heat Shock Protein HSP60 in Left Ventricular Cardiomyocytes of Hypertensive Rats with and without Insulin-Dependent Diabetes Mellitus., [RefSeq, PubMed]; The present study revealed that carvedilol protected cardiomyocytes from apoptosis by inhibiting miR-1 expression in cardiomyocytes; this cardioprotective effect was associated with increased HSP60 expression within cardiomyocytes in ischemia., [RefSeq, PubMed]; This research suggests that HSP60 may play an important role in auditory function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 23, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P19226;P19227;P97602", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0034185 apolipoprotein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0030135 coated vesicle;GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0032727 positive regulation of interferon-alpha production;GO:0043032 positive regulation of macrophage activation;GO:0045041 protein import into mitochondrial intermembrane space", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P63039-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63116-1", "uniprot_id": [ { "id": "AAA1_RAT", "url": "https://www.uniprot.org/uniprot/P63116", "type": "external" } ], "mass": 57549.0, "length": 530, "protein_name": "Asc-type amino acid transporter 1", "gene_name": "Slc7a10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc7a10; Asc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-210991); (R-RNO-352230)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23426681", "class_list": "", "function": "Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:23426681). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (PubMed:23426681). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW25;Q9JMH8", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0097440 apical dendrite;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0015804 neutral amino acid transport;GO:0042941 D-alanine transmembrane transport;GO:0042942 D-serine transmembrane transport;GO:1903444 negative regulation of brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63116-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63259-1", "uniprot_id": [ { "id": "ACTG_RAT", "url": "https://www.uniprot.org/uniprot/P63259", "type": "external" } ], "mass": 41793.0, "length": 375, "protein_name": "Actin, cytoplasmic 2", "gene_name": "Actg1", "organism": "Rat", "refseq_name": "actin, cytoplasmic 2", "refseq_ac": [ { "id": "NP_001120921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120921", "type": "external" } ], "gene_names_uniprotkb": "Actg1; Actg", "gene_names_refseq": "Actg1; Actg", "protein_names_uniprotkb": "Actin, cytoplasmic 2; 3.6.4.-; Gamma-actin", "protein_names_refseq": "actin, cytoplasmic 2; actin, gamma, cytoplasmic 1; gamma-actin", "tax_id": 10116, "disease": "", "pathway": " (rno:287876); (R-RNO-114608); (R-RNO-190873); (R-RNO-196025); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-418990); (R-RNO-437239); (R-RNO-4420097); (R-RNO-445095); (R-RNO-446353); (R-RNO-5250924); (R-RNO-5626467); (R-RNO-5663213); (R-RNO-5663220); (R-RNO-5674135); (R-RNO-5689603); (R-RNO-5696394); (R-RNO-8856828); (R-RNO-9035034); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9933937); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9933947); (R-RNO-9934037); (R-RNO-9953170); (R-RNO-9958825)", "pathway_count": 29, "publication_count": 3, "publication_id_list": "18047804;2372296;2402472", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02571;P14104;P99022", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0120192 tight junction assembly;GO:0001525 angiogenesis;GO:0007409 axonogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63259-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63278-4", "uniprot_id": [ { "id": "AMELX_RAT", "url": "https://www.uniprot.org/uniprot/P63278", "type": "external" } ], "mass": 23483.0, "length": 210, "protein_name": "Amelogenin, X isoform", "gene_name": "Amelx", "organism": "Rat", "refseq_name": "amelogenin, X isoform isoform 2 precursor", "refseq_ac": [ { "id": "NP_001258002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258002", "type": "external" } ], "gene_names_uniprotkb": "Amelx; Amel; Amgx", "gene_names_refseq": "Amelx; Amel; LRAP", "protein_names_uniprotkb": "Amelogenin, X isoform; LRAP; Leucine-rich amelogenin peptide", "protein_names_refseq": "amelogenin X chromosome; amelogenin, X isoform isoform 2 precursor; leucine-rich amelogenin peptide", "tax_id": 10116, "disease": "autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); amelogenesis imperfecta type 1E (Disease Ontology:DOID:0110058); amelogenesis imperfecta (Disease Ontology:DOID:2187)", "pathway": " (rno:29160); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "20387077;20404336;7948026;8297387;8600184", "class_list": "", "function": "Interactions between collagen and amelogenin might play an important role in the formation of the DEB providing structural continuity between dentin and enamel, [RefSeq, PubMed]; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel., [UniProtKB]; The aim of this study was to verify the expression, distribution and role of Rho GTPases in ameloblasts and odontoblasts during tooth development in correlation with actin and tubulin arrangements and amelogenin and dentin sialophosphoprotein expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P45559;Q62945;Q63640;Q78E56", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0008083 growth factor activity;GO:0030345 structural constituent of tooth enamel", "go_cellular_component": "GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0030139 endocytic vesicle;GO:0005604 basement membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007584 response to nutrient;GO:0042127 regulation of cell population proliferation;GO:0051592 response to calcium ion;GO:0042475 odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63278-4", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68035-1", "uniprot_id": [ { "id": "ACTC_RAT", "url": "https://www.uniprot.org/uniprot/P68035", "type": "external" } ], "mass": 42019.0, "length": 377, "protein_name": "Actin, alpha cardiac muscle 1", "gene_name": "Actc1", "organism": "Rat", "refseq_name": "actin, alpha cardiac muscle 1", "refseq_ac": [ { "id": "NP_062056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062056", "type": "external" } ], "gene_names_uniprotkb": "Actc1; Actc", "gene_names_refseq": "Actc1", "protein_names_uniprotkb": "Actin, alpha cardiac muscle 1; 3.6.4.-; Alpha-cardiac actin", "protein_names_refseq": "actin, alpha cardiac muscle 1; actin, alpha, cardiac 1; alpha-actin cardiac; alpha-cardiac actin", "tax_id": 10116, "disease": "Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); atrial heart septal defect 5 (Disease Ontology:DOID:0110110); Bartter disease type 3 (Disease Ontology:DOID:0110144); Bartter disease type 4b (Disease Ontology:DOID:0110146); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); dilated cardiomyopathy 1R (Disease Ontology:DOID:0110456); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); sensorineural hearing loss (Disease Ontology:DOID:10003); intestinal atresia (Disease Ontology:DOID:10486); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); dilated cardiomyopathy (Disease Ontology:DOID:12930); Moyamoya disease (Disease Ontology:DOID:13099); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); myopathy (Disease Ontology:DOID:423); Bartter disease (Disease Ontology:DOID:445)", "pathway": " (rno:29275); (R-RNO-390522); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9958825)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "18988896;26109417;34502162;38843836", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A0JPJ4;P04270", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0017022 myosin binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium", "go_biological_process": "GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0007015 actin filament organization;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P68035-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68136-1", "uniprot_id": [ { "id": "ACTS_RAT", "url": "https://www.uniprot.org/uniprot/P68136", "type": "external" } ], "mass": 42051.0, "length": 377, "protein_name": "Actin, alpha skeletal muscle", "gene_name": "Acta1", "organism": "Rat", "refseq_name": "actin, alpha skeletal muscle", "refseq_ac": [ { "id": "NP_062085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062085", "type": "external" } ], "gene_names_uniprotkb": "Acta1; Acta", "gene_names_refseq": "Acta1", "protein_names_uniprotkb": "Actin, alpha skeletal muscle; 3.6.4.-; Alpha-actin-1", "protein_names_refseq": "actin alpha 1; actin, alpha skeletal muscle; alpha-actin-1", "tax_id": 10116, "disease": "aortic dissection (Disease Ontology:DOID:0080685); Baraitser-Winter syndrome 1 (Disease Ontology:DOID:0081112); congenital myopathy 2B (Disease Ontology:DOID:0081339); congenital myopathy 2C (Disease Ontology:DOID:0081340); hypertrophic cardiomyopathy 11 (Disease Ontology:DOID:0110317); autosomal dominant nonsyndromic deafness 20 (Disease Ontology:DOID:0110550); nemaline myopathy 3 (Disease Ontology:DOID:0110927); autosomal dominant osteopetrosis 2 (Disease Ontology:DOID:0110938); autosomal recessive osteopetrosis 4 (Disease Ontology:DOID:0110944); intestinal atresia (Disease Ontology:DOID:10486); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Moyamoya disease (Disease Ontology:DOID:13099); osteopetrosis (Disease Ontology:DOID:13533); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); nemaline myopathy (Disease Ontology:DOID:3191); lysosomal storage disease (Disease Ontology:DOID:3211); congenital structural myopathy (Disease Ontology:DOID:422); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:29437); (R-RNO-390522); (R-RNO-9764561); (R-RNO-9913351); (R-RNO-9958825)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "17289664;19322778;23110217;23420843;6287276;6894330", "class_list": "", "function": "Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; Analysis of the pattern of of evolutionarily conserved basic and acidic residues that constitutes the binding interface of actin-tropomyosin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02568;P99020", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0009612 response to mechanical stimulus;GO:0030240 skeletal muscle thin filament assembly;GO:0043503 skeletal muscle fiber adaptation;GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P68136-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69478-1", "uniprot_id": [ { "id": "CHSTB_RAT", "url": "https://www.uniprot.org/uniprot/P69478", "type": "external" } ], "mass": 41626.0, "length": 352, "protein_name": "Carbohydrate sulfotransferase 11", "gene_name": "Chst11", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 11", "refseq_ac": [ { "id": "NP_001101549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101549", "type": "external" } ], "gene_names_uniprotkb": "Chst11", "gene_names_refseq": "C4ST1; Chst11", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 11; 2.8.2.5; C4S-1; C4ST-1; C4ST1; Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1", "protein_names_refseq": "C4S-1; C4ST-1; C4ST; carbohydrate (chondroitin 4) sulfotransferase 11; carbohydrate sulfotransferase 11; chondroitin 4-O-sulfotransferase 1; chondroitin 4-sulfotransferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314694); (R-RNO-2022870)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10722746", "class_list": "", "function": "Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.5", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity;GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0001701 in utero embryonic development;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P69478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70500-1", "uniprot_id": [ { "id": "CDIPT_RAT", "url": "https://www.uniprot.org/uniprot/P70500", "type": "external" } ], "mass": 23613.0, "length": 213, "protein_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "gene_name": "Cdipt", "organism": "Rat", "refseq_name": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase", "refseq_ac": [ { "id": "NP_620254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620254", "type": "external" } ], "gene_names_uniprotkb": "Cdipt; Pis1", "gene_names_refseq": "Cdipt; Pis1; Pis", "protein_names_uniprotkb": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase; 2.7.8.11; PI synthase; Phosphatidylinositol synthase; PtdIns synthase", "protein_names_refseq": "CDP-diacylglycerol--inositol 3-phosphatidyltransferase; PI synthase; phosphatidylinositol synthase; ptdIns synthase", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:192260); (R-RNO-1483226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16641100;3032971;7998949;8804431", "class_list": "", "function": "Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.11", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity;GO:0019992 diacylglycerol binding;GO:0043178 alcohol binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process;GO:0046341 CDP-diacylglycerol metabolic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70500-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70673-1", "uniprot_id": [ { "id": "KCJ11_RAT", "url": "https://www.uniprot.org/uniprot/P70673", "type": "external" } ], "mass": 43608.0, "length": 390, "protein_name": "ATP-sensitive inward rectifier potassium channel 11", "gene_name": "Kcnj11", "organism": "Rat", "refseq_name": "ATP-sensitive inward rectifier potassium channel 11", "refseq_ac": [ { "id": "NP_112648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112648", "type": "external" } ], "gene_names_uniprotkb": "Kcnj11", "gene_names_refseq": "Kcnj11; Kir6.2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 11; BIR; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium voltage-gated channel subfamily J member 11", "tax_id": 10116, "disease": "permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); transient neonatal diabetes mellitus 3 (Disease Ontology:DOID:0061172); familial hyperinsulinemic hypoglycemia 2 (Disease Ontology:DOID:0070218); Parkinsonism (Disease Ontology:DOID:0080855); maturity-onset diabetes of the young type 13 (Disease Ontology:DOID:0111110); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hyperinsulinism (Disease Ontology:DOID:2018); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:83535); (R-RNO-1296025); (R-RNO-382556); (R-RNO-422356); (R-RNO-5578775)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "19357830;28082085;28092267;28842488;30074836;30868916;38509107;8607800;8798681", "class_list": "", "function": "Both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations., [RefSeq, PubMed]; Intricate interactions between TMD0, the loop following TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP density is observed, suggest SUR1 may contribute to ATP and PIP2 binding to enhance Kir6.2 sensitivity to both. Publication Status: Online-Only, [RefSeq, PubMed]; Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). In pancreatic cells, it forms KATP channels with ABCC8/SUR1 (By similarity). Can form cardiac and smooth muscle-type KATP channels with ABCC9 (By similarity)., [UniProtKB, UniProtKB]; Our findings suggest that the NF-kappaB, p38 MAPK, and PKC signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of Alzheimer's disease., [RefSeq, PubMed]; The E23K variant of the KATP channel increased the susceptibility to ventricular arrhythmia under acute ischemia stress., [RefSeq, PubMed]; Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62906;Q9JM48", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031072 heat shock protein binding;GO:0044325 transmembrane transporter binding;GO:0015272 ATP-activated inward rectifier potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0071333 cellular response to glucose stimulus;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70673-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80067-1", "uniprot_id": [ { "id": "CATC_RAT", "url": "https://www.uniprot.org/uniprot/P80067", "type": "external" } ], "mass": 52235.0, "length": 462, "protein_name": "Dipeptidyl peptidase 1", "gene_name": "Ctsc", "organism": "Rat", "refseq_name": "dipeptidyl peptidase 1 precursor", "refseq_ac": [ { "id": "NP_058793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058793", "type": "external" } ], "gene_names_uniprotkb": "Ctsc", "gene_names_refseq": "CATC; Ctsc; DPP-I; DPPI", "protein_names_uniprotkb": "Dipeptidyl peptidase 1; 3.4.14.1; Cathepsin C; Cathepsin J; DPP-I; DPPI; Dipeptidyl peptidase I exclusion domain chain; Dipeptidyl peptidase I heavy chain; Dipeptidyl peptidase I light chain; Dipeptidyl peptidase I; Dipeptidyl transferase", "protein_names_refseq": "cathepsin J; dipeptidyl peptidase 1 precursor; dipeptidyl peptidase 1; dipeptidyl peptidase I; dipeptidyl transferase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); brain ischemia (Disease Ontology:DOID:2316); Papillon-Lefevre disease (Disease Ontology:DOID:3389); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25423); (R-RNO-204005); (R-RNO-2132295); (R-RNO-5694530); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "11602245;1515062;1740150;1885565;26884336;28665049;29393594;32302668;34828301", "class_list": "", "function": "Cathepsin C Regulates Cytokine-Induced Apoptosis in beta-Cell Model Systems. Publication Status: Online-Only, [RefSeq, PubMed]; Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia., [RefSeq, PubMed]; Findings demonstrate the role of DPPI in regulating MCs and NPs activation, and modulating proteolysis in the process of RA., [RefSeq, PubMed]; Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases., [RefSeq, PubMed]; Thiol protease (PubMed:1740150). Has dipeptidylpeptidase activity (PubMed:1740150). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate (PubMed:1740150). Can act as both an exopeptidase and endopeptidase (By similarity). Activates serine proteases such as elastase, cathepsin G and granzymes A and B (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P80068", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031404 chloride ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:1903980 positive regulation of microglial cell activation;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0051603 proteolysis involved in protein catabolic process;GO:1903052 positive regulation of proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P80067-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80202-1", "uniprot_id": [ { "id": "ACV1B_RAT", "url": "https://www.uniprot.org/uniprot/P80202", "type": "external" } ], "mass": 56805.0, "length": 505, "protein_name": "Activin receptor type-1B", "gene_name": "Acvr1b", "organism": "Rat", "refseq_name": "activin receptor type-1B precursor", "refseq_ac": [ { "id": "NP_954700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954700", "type": "external" } ], "gene_names_uniprotkb": "Acvr1b; Acvrlk4; Alk4", "gene_names_refseq": "Acvr1b; Skr2", "protein_names_uniprotkb": "Activin receptor type-1B; 2.7.11.30; ACTR-IB; ALK-4; Activin receptor type IB; Activin receptor-like kinase 4; SKR2; Serine/threonine-protein kinase receptor R2", "protein_names_refseq": "ACTR-IB; ALK-4; Serine/threonine-protein kinase receptor R2; activin A receptor, type IB; activin receptor type IB; activin receptor type-1B precursor; activin receptor type-1B; activin receptor-like kinase 4", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (rno:29381); (R-RNO-1502540)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7813622;8395914", "class_list": "", "function": "Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048179 activin receptor complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80202-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80432-1", "uniprot_id": [ { "id": "COX7C_RAT", "url": "https://www.uniprot.org/uniprot/P80432", "type": "external" } ], "mass": 7375.0, "length": 63, "protein_name": "Cytochrome c oxidase subunit 7C, mitochondrial", "gene_name": "Cox7c", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 7C, mitochondrial", "refseq_ac": [ { "id": "NP_001128177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128177", "type": "external" } ], "gene_names_uniprotkb": "Cox7c; Cox7c1", "gene_names_refseq": "Cox7c1; Cox7c", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7C, mitochondrial; Cytochrome c oxidase polypeptide VIIIA; Cytochrome c oxidase polypeptide VIIc", "protein_names_refseq": "Cytochrome c oxidase polypeptide VIIIA; Cytochrome c oxidase polypeptide VIIc; cytochrome c oxidase subunit 7C, mitochondrial; cytochrome c oxidase, subunit VIIc", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:100188937); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RYT3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80432-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82106-1", "uniprot_id": [ { "id": "DEF5_RAT", "url": "https://www.uniprot.org/uniprot/P82106", "type": "external" } ], "mass": 10242.0, "length": 93, "protein_name": "Defensin 5", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Defensin 5; Enteric defensin; RD-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10456932", "class_list": "", "function": "Probably contributes to the antimicrobial barrier function of the small intestine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82106-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85968-1", "uniprot_id": [ { "id": "6PGD_RAT", "url": "https://www.uniprot.org/uniprot/P85968", "type": "external" } ], "mass": 53236.0, "length": 483, "protein_name": "6-phosphogluconate dehydrogenase, decarboxylating", "gene_name": "Pgd", "organism": "Rat", "refseq_name": "6-phosphogluconate dehydrogenase, decarboxylating", "refseq_ac": [ { "id": "NP_001292364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292364", "type": "external" } ], "gene_names_uniprotkb": "Pgd", "gene_names_refseq": "Cc2-27; Pgd", "protein_names_uniprotkb": "6-phosphogluconate dehydrogenase, decarboxylating; 1.1.1.44", "protein_names_refseq": "6-phosphogluconate dehydrogenase, decarboxylating-like; 6-phosphogluconate dehydrogenase, decarboxylating", "tax_id": 10116, "disease": "", "pathway": " (rno:100360180); (R-RNO-71336)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19343716;21930213;25228019", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH., [UniProtKB]; Examination of changes in enzyme activities of erythrocyte glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rats given Naringenin and Lead acetate., [RefSeq, PubMed]; The enzymes of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase,and glutathione reductase were purified from rat kidney in one chromatographic step consisting of the use of the 2',5'-ADP Sepharose 4B by using different elution buffers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.44", "type": "external" } ], "go_molecular_function": "GO:0031406 carboxylic acid binding;GO:0030246 carbohydrate binding;GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006098 pentose-phosphate shunt;GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0019322 pentose biosynthetic process;GO:0019521 D-gluconate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P85968-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97520-1", "uniprot_id": [ { "id": "C5AR1_RAT", "url": "https://www.uniprot.org/uniprot/P97520", "type": "external" } ], "mass": 39417.0, "length": 352, "protein_name": "C5a anaphylatoxin chemotactic receptor 1", "gene_name": "C5ar1", "organism": "Rat", "refseq_name": "C5a anaphylatoxin chemotactic receptor 1", "refseq_ac": [ { "id": "NP_446071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446071", "type": "external" } ], "gene_names_uniprotkb": "C5ar1; C5r1", "gene_names_refseq": "C5a-R; C5aR; C5ar1; C5r1", "protein_names_uniprotkb": "C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR", "protein_names_refseq": "C5a anaphylatoxin chemotactic receptor 1; complement component 5, receptor 1; complement component 5a receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:113959); (R-RNO-375276); (R-RNO-418594); (R-RNO-6798695); (R-RNO-977606)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "12464600;22673903;28690033;29393594;34637270;38165570;38326494;9272704;9464523", "class_list": "", "function": "C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms. Publication Status: Online-Only, [RefSeq, PubMed]; C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion., [RefSeq, PubMed]; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:9464523). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (By similarity). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (By similarity)., [UniProtKB, PubMed, UniProtKB]; Silenced-C5ar1 improved multiple organ injury in sepsis rats via inhibiting neutrophil extracellular trap., [RefSeq, PubMed]; Study concludes, Toll-like receptor 4 (TLR4) and C5aR1 played a vital role during ischemia and reperfusion brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09088", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004878 complement component C5a receptor activity;GO:0001856 complement component C5a binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0038178 complement component C5a signaling pathway;GO:0001774 microglial cell activation;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97520-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97545-1", "uniprot_id": [ { "id": "CCL11_RAT", "url": "https://www.uniprot.org/uniprot/P97545", "type": "external" } ], "mass": 10851.0, "length": 97, "protein_name": "Eotaxin", "gene_name": "Ccl11", "organism": "Rat", "refseq_name": "eotaxin precursor", "refseq_ac": [ { "id": "NP_062078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062078", "type": "external" } ], "gene_names_uniprotkb": "Ccl11; Scya11", "gene_names_refseq": "Ccl11; Scya11", "protein_names_uniprotkb": "Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11", "protein_names_refseq": "C-C motif chemokine 11; chemokine (C-C motif) ligand 11; eosinophil chemotactic protein; eotaxin precursor; eotaxin; small inducible cytokine subfamily A11; small-inducible cytokine A11", "tax_id": 10116, "disease": "nephrotic syndrome type 1 (Disease Ontology:DOID:0080390); pleurisy (Disease Ontology:DOID:10247); viral pneumonia (Disease Ontology:DOID:10533); interstitial nephritis (Disease Ontology:DOID:1063); allergic conjunctivitis (Disease Ontology:DOID:11204); mucopolysaccharidosis IV (Disease Ontology:DOID:12804); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); bronchiolitis (Disease Ontology:DOID:2942); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); hyperglycemia (Disease Ontology:DOID:4195); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); cataract (Disease Ontology:DOID:83); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29397); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24646746;28279120;34830041;9396866;9458816", "class_list": "", "function": "Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions., [RefSeq, PubMed]; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (PubMed:9458816). Binds to CCR3 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08780", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0048018 receptor ligand activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding;GO:0031728 CCR3 chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007015 actin filament organization;GO:0007611 learning or memory;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97545-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97776-1", "uniprot_id": [ { "id": "ADA18_RAT", "url": "https://www.uniprot.org/uniprot/P97776", "type": "external" } ], "mass": 48200.0, "length": 445, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 18", "gene_name": "Adam18", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adam18; Tmdc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 18; ADAM 18; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III; tMDC III", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9291465", "class_list": "", "function": "Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97776-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97884-1", "uniprot_id": [ { "id": "CCL20_RAT", "url": "https://www.uniprot.org/uniprot/P97884", "type": "external" } ], "mass": 10875.0, "length": 96, "protein_name": "C-C motif chemokine 20", "gene_name": "Ccl20", "organism": "Rat", "refseq_name": "C-C motif chemokine 20 precursor", "refseq_ac": [ { "id": "NP_062106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062106", "type": "external" } ], "gene_names_uniprotkb": "Ccl20; Scya20; St38", "gene_names_refseq": "Ccl20; MIP3A; ST38; Scya20", "protein_names_uniprotkb": "C-C motif chemokine 20; Beta-chemokine exodus-1; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; MIP-3-alpha; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20", "protein_names_refseq": "C-C motif chemokine 20 precursor; C-C motif chemokine 20; CC chemokine LARC; CC chemokine ST38; MIP-3-alpha; beta-chemokine exodus-1; chemokine (C-C motif) ligand 20; liver and activation-regulated chemokine; macrophage inflammatory protein 3 alpha; small inducible cytokine subfamily A20; small-inducible cytokine A20", "tax_id": 10116, "disease": "exanthem (Disease Ontology:DOID:0050486); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); anogenital venereal wart (Disease Ontology:DOID:11168); Lyme disease (Disease Ontology:DOID:11729); fungal infectious disease (Disease Ontology:DOID:1564); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); acrodermatitis (Disease Ontology:DOID:2722); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); skin papilloma (Disease Ontology:DOID:3178); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); ulcerative colitis (Disease Ontology:DOID:8577); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:29538); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "26704184;30619251;9916893", "class_list": "", "function": "Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells., [UniProtKB, UniProtKB, UniProtKB]; Ginkgolide B could alleviate MI/RI-induced inflammatory response through A20-NF-kappaB signal pathway, which may give us new insights into the preventive strategies for myocardial ischemia/reperfusion injury disease. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest a potential mechanism for the recruitment of IL-17-producing cells to degenerated intervertebral discs via a CCL20/CCR6 axis in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008009 chemokine activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0019722 calcium-mediated signaling;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00195-1", "uniprot_id": [ { "id": "CNGA2_RAT", "url": "https://www.uniprot.org/uniprot/Q00195", "type": "external" } ], "mass": 76177.0, "length": 664, "protein_name": "Cyclic nucleotide-gated channel alpha-2", "gene_name": "Cnga2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cnga2; Cncg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-2; CNCalpha3; CNG channel alpha-2; CNG-2; CNG2; Cyclic nucleotide-gated channel alpha 3; OCNC1; Olfactory cyclic nucleotide-gated channel subunit 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mevalonic aciduria (Disease Ontology:DOID:0050452); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); atrial fibrillation (Disease Ontology:DOID:0060224); mastoiditis (Disease Ontology:DOID:0060322); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); pelvic inflammatory disease (Disease Ontology:DOID:1003); bacterial infectious disease (Disease Ontology:DOID:104); interstitial nephritis (Disease Ontology:DOID:1063); renal hypertension (Disease Ontology:DOID:1073); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); heart disease (Disease Ontology:DOID:114); pyelonephritis (Disease Ontology:DOID:11400); hypertensive retinopathy (Disease Ontology:DOID:11561); familial hyperlipidemia (Disease Ontology:DOID:1168); iron deficiency anemia (Disease Ontology:DOID:11758); vestibular neuronitis (Disease Ontology:DOID:12683); cardiovascular system disease (Disease Ontology:DOID:1287); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); low tension glaucoma (Disease Ontology:DOID:13544); aspergillosis (Disease Ontology:DOID:13564); pharyngoconjunctival fever (Disease Ontology:DOID:13801); interstitial cystitis (Disease Ontology:DOID:13949); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); Parkinson's disease (Disease Ontology:DOID:14330); aggressive periodontitis (Disease Ontology:DOID:1474); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); mouth disease (Disease Ontology:DOID:403); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); acute stress disorder (Disease Ontology:DOID:6088); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); arthritis (Disease Ontology:DOID:848); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); intermediate coronary syndrome (Disease Ontology:DOID:8805); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); otitis externa (Disease Ontology:DOID:9463); bacterial meningitis (Disease Ontology:DOID:9470); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25411); (R-RNO-5620916)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10377344;10594674;11764791;1697649;27405959;7522325;9878057", "class_list": "", "function": "Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 85, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549G7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0060170 ciliary membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051899 membrane depolarization;GO:0098655 monoatomic cation transmembrane transport;GO:0006813 potassium ion transport;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q00195-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00969-1", "uniprot_id": [ { "id": "ATF2_RAT", "url": "https://www.uniprot.org/uniprot/Q00969", "type": "external" } ], "mass": 52287.0, "length": 487, "protein_name": "Cyclic AMP-dependent transcription factor ATF-2", "gene_name": "Atf2", "organism": "Rat", "refseq_name": "cyclic AMP-dependent transcription factor ATF-2", "refseq_ac": [ { "id": "NP_112280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112280", "type": "external" } ], "gene_names_uniprotkb": "Atf2", "gene_names_refseq": "Atf2", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-2; Activating transcription factor 2; cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2", "protein_names_refseq": "cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2; cyclic AMP-dependent transcription factor ATF-2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); meconium aspiration syndrome (Disease Ontology:DOID:11049); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); osteochondrodysplasia (Disease Ontology:DOID:2256); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:81647); (R-RNO-3214847); (R-RNO-450341); (R-RNO-9018519)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15340146;1714459;22673903;26601778;26781764;29921170", "class_list": "", "function": "Following unilateral intracochlear stimulation, study quantified an increase of Fos expression with a simultaneous and locally corresponding decrease of pATF2 expression in major auditory brainstem regions of both hearing and deaf rats, [RefSeq, PubMed]; The results suggest that the increase in uncoupling protein 1 (UCP1) content may occur via p38 MAPK and ATF2., [RefSeq, PubMed]; This study demonstrated that ATF2 participates in nerve injury-induced tactile allodynia and thermal hyperalgesia in rats., [RefSeq, PubMed]; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62870", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0003360 brainstem development;GO:0021754 facial nucleus development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q00969-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02589-1", "uniprot_id": [ { "id": "ADPRH_RAT", "url": "https://www.uniprot.org/uniprot/Q02589", "type": "external" } ], "mass": 39961.0, "length": 362, "protein_name": "ADP-ribosylhydrolase ARH1", "gene_name": "Adprh", "organism": "Rat", "refseq_name": "ADP-ribosylhydrolase ARH1", "refseq_ac": [ { "id": "NP_899154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899154", "type": "external" } ], "gene_names_uniprotkb": "Adprh; Arh1", "gene_names_refseq": "ADPRHA; Adprh", "protein_names_uniprotkb": "ADP-ribosylhydrolase ARH1; 3.2.2.19; ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylarginine hydrolase; [Protein ADP-ribosylarginine] hydrolase", "protein_names_refseq": "ADP-ribose-L-arginine cleaving enzyme; ADP-ribosylhydrolase ARH1; [Protein ADP-ribosylarginine] hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:25371)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1375222", "class_list": "", "function": "Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66H27", "ec_number_list": [ { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.106", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003875 ADP-ribosylarginine hydrolase activity;GO:0030955 potassium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0036211 protein modification process;GO:0051725 protein de-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q02589-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03344-1", "uniprot_id": [ { "id": "ATIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q03344", "type": "external" } ], "mass": 12248.0, "length": 107, "protein_name": "ATPase inhibitor, mitochondrial", "gene_name": "Atp5if1", "organism": "Rat", "refseq_name": "ATPase inhibitor, mitochondrial precursor", "refseq_ac": [ { "id": "NP_037047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037047", "type": "external" } ], "gene_names_uniprotkb": "Atp5if1; Atpif1; Atpi; If1", "gene_names_refseq": "Atp5if1; Atpif1; Atpi; IF1PA", "protein_names_uniprotkb": "ATPase inhibitor, mitochondrial; ATP synthase F1 subunit epsilon; IF(1); IF1; Inhibitor of F(1)F(o)-ATPase", "protein_names_refseq": "ATP synthase F1 subunit epsilon; ATPase inhibitor (rat mitochondrial IF1 protein); ATPase inhibitor, mitochondrial precursor; ATPase inhibitor, mitochondrial; ATPase inhibitory factor 1; IF(1); IF1; inhibitor of F(1)F(o)-ATPase", "tax_id": 10116, "disease": "blindness (Disease Ontology:DOID:1432)", "pathway": " (rno:25392)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "29380352;29393594;32005857;33922643;36657294;36881363;7612645;8442667;8448208", "class_list": "", "function": "ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced astrocyte injury in vitro: A rat model of ischemic brain injury., [RefSeq, PubMed]; ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIdelta. Publication Status: Online-Only, [RefSeq, PubMed]; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expression and function of mitochondrial inhibitor factor-1 and TASK channels in adrenal cells., [RefSeq, PubMed]; Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that IF1 is a negative regulator of insulin secretion involved in pancreatic beta-cell glucose sensing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JMZ8", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0002931 response to ischemia;GO:0030218 erythrocyte differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0051882 mitochondrial depolarization;GO:0072593 reactive oxygen species metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03344-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03484-1", "uniprot_id": [ { "id": "CEBPD_RAT", "url": "https://www.uniprot.org/uniprot/Q03484", "type": "external" } ], "mass": 28600.0, "length": 268, "protein_name": "CCAAT/enhancer-binding protein delta", "gene_name": "Cebpd", "organism": "Rat", "refseq_name": "CCAAT/enhancer-binding protein delta", "refseq_ac": [ { "id": "NP_037286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037286", "type": "external" } ], "gene_names_uniprotkb": "Cebpd; Celf", "gene_names_refseq": "C/EBPd; CELF; Cebpd", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein delta; C/EBP delta; Transcription factor CELF", "protein_names_refseq": "C/EBP-delta; C/EBPdelta; CCAAT/enhancer binding protein (C/EBP), delta; CCAAT/enhancer-binding protein delta; c/EBP delta; transcription factor CELF", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); carnitine palmitoyltransferase I deficiency (Disease Ontology:DOID:0090129); alcoholic hepatitis (Disease Ontology:DOID:12351); lipid metabolism disorder (Disease Ontology:DOID:3146); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); prolactinoma (Disease Ontology:DOID:5394); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25695)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12145301;1714459;23426691;26187065;29482641;38857839", "class_list": "", "function": "C/EBPdelta plays a critical role in both memory consolidation and reconsolidation., [RefSeq, PubMed]; CEBPB and CEBPD regulate PI3K inflammatory gene expression, [RefSeq, PubMed]; CEBPD aggravates apoptosis and oxidative stress of neuron after ischemic stroke by Nrf2/HO-1 pathway., [RefSeq, PubMed]; DHT activated AR inhibits gene transactivation by C/EBPdelta, and transgenic C/EBPdelta expression inhibits AR activity, [RefSeq, PubMed]; Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03484-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04827-1", "uniprot_id": [ { "id": "CCND2_RAT", "url": "https://www.uniprot.org/uniprot/Q04827", "type": "external" } ], "mass": 32826.0, "length": 288, "protein_name": "G1/S-specific cyclin-D2", "gene_name": "Ccnd2", "organism": "Rat", "refseq_name": "G1/S-specific cyclin-D2", "refseq_ac": [ { "id": "NP_071603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071603", "type": "external" } ], "gene_names_uniprotkb": "Ccnd2; Vin-1", "gene_names_refseq": "Ccnd2", "protein_names_uniprotkb": "G1/S-specific cyclin-D2; Vin-1 proto-oncogene", "protein_names_refseq": "G1/S-specific cyclin-D2; vin-1 proto-oncogene", "tax_id": 10116, "disease": "", "pathway": " (rno:64033); (R-RNO-69231); (R-RNO-8934593); (R-RNO-9754119)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;7926809;8502486", "class_list": "", "function": "Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071378 cellular response to growth hormone stimulus;GO:0001889 liver development;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q04827-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05683-1", "uniprot_id": [ { "id": "DCE2_RAT", "url": "https://www.uniprot.org/uniprot/Q05683", "type": "external" } ], "mass": 65402.0, "length": 585, "protein_name": "Glutamate decarboxylase 2", "gene_name": "Apbb1ip; Gad2", "organism": "Rat", "refseq_name": "glutamate decarboxylase 2", "refseq_ac": [ { "id": "NP_036695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036695", "type": "external" } ], "gene_names_uniprotkb": "Apbb1ip; Gad2; Gad2; Gad65", "gene_names_refseq": "Gad2; gad65", "protein_names_uniprotkb": "Glutamate decarboxylase 2; 4.1.1.15; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform", "protein_names_refseq": "65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 2; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65", "tax_id": 10116, "disease": "spastic cerebral palsy (Disease Ontology:DOID:0050669); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); gestational diabetes (Disease Ontology:DOID:11714); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); type 1 diabetes mellitus (Disease Ontology:DOID:9744); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24380); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-5674135); (R-RNO-888568); (R-RNO-888590)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "12657523;1321158;15728483;18305140;2069816;22673903;33236473;3385490;34972242;36587827;38194067;8132714;8999827", "class_list": "", "function": "Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the production of GABA., [UniProtKB, PubMed]; Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging., [RefSeq, PubMed]; Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats., [RefSeq, PubMed]; Parvalbumin in the metabolic pathway of glutamate and gamma-aminobutyric acid: Influence on expression of GAD65 and GAD67., [RefSeq, PubMed]; Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0044877 protein-containing complex binding;GO:0004351 glutamate decarboxylase activity;GO:0016595 glutamate binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0007268 chemical synaptic transmission;GO:0071456 cellular response to hypoxia;GO:0032570 response to progesterone;GO:0042220 response to cocaine", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q05683-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06393-1", "uniprot_id": [ { "id": "CLCKA_RAT", "url": "https://www.uniprot.org/uniprot/Q06393", "type": "external" } ], "mass": 75569.0, "length": 687, "protein_name": "Chloride channel protein ClC-Ka", "gene_name": "Clcnka", "organism": "Rat", "refseq_name": "chloride channel protein ClC-Ka", "refseq_ac": [ { "id": "NP_445779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445779", "type": "external" } ], "gene_names_uniprotkb": "Clcnka; Clcnk1", "gene_names_refseq": "Clcnk1; Clcnka", "protein_names_uniprotkb": "Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1", "protein_names_refseq": "chloride channel K1; chloride channel Ka; chloride channel protein ClC-Ka; chloride channel, voltage-sensitive Ka; clC-K1", "tax_id": 10116, "disease": "Bartter disease type 4b (Disease Ontology:DOID:0110146); sensorineural hearing loss (Disease Ontology:DOID:10003); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:79425); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12111250;12759757;16849430;18945830;20538786;7680033;8034678;8041726", "class_list": "", "function": "Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:12111250, PubMed:16849430, PubMed:20538786). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain. CLCNKA:BSND channels are activated upon membrane hyperpolarization mostly controlled by fast gating (PubMed:12111250, PubMed:16849430, PubMed:20538786). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis., [RefSeq, PubMed]; This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 5. This gene is syntenic with human CLCNKB (geneID:1188).[provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97709", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0051592 response to calcium ion;GO:0001822 kidney development;GO:0009268 response to pH;GO:0006821 chloride transport;GO:0007589 body fluid secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q06393-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06647-1", "uniprot_id": [ { "id": "ATPO_RAT", "url": "https://www.uniprot.org/uniprot/Q06647", "type": "external" } ], "mass": 23398.0, "length": 213, "protein_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial", "gene_name": "Atp5po", "organism": "Rat", "refseq_name": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor", "refseq_ac": [ { "id": "NP_620238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620238", "type": "external" } ], "gene_names_uniprotkb": "Atp5po; Atp5o", "gene_names_refseq": "Atp5o; Atp5po; Atpo; Oscp", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O; OSCP; Oligomycin sensitivity conferral protein; Sperm flagella protein 4", "protein_names_refseq": "ATP synthase peripheral stalk subunit OSCP, mitochondrial precursor; ATP synthase peripheral stalk subunit OSCP, mitochondrial; ATP synthase subunit O, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein); oligomycin sensitivity conferral protein; sperm flagella protein 4", "tax_id": 10116, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 7 (Disease Ontology:DOID:0070464); Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (rno:192241); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "17575325;19423663;26446791;27213235;34502162;38007588;38843836;8448208", "class_list": "", "function": "Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:1903924 estradiol binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0071345 cellular response to cytokine stimulus;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q06647-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06826-1", "uniprot_id": [ { "id": "BMP4_RAT", "url": "https://www.uniprot.org/uniprot/Q06826", "type": "external" } ], "mass": 46541.0, "length": 408, "protein_name": "Bone morphogenetic protein 4", "gene_name": "Bmp4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bmp4; Bmp-4; Dvr-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Bone morphogenetic protein 4; BMP-2B; BMP-4; Bone morphogenetic protein 2B", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); Ullrich congenital muscular dystrophy (Disease Ontology:DOID:0050558); tooth agenesis (Disease Ontology:DOID:0050591); atrioventricular septal defect (Disease Ontology:DOID:0050651); juvenile polyposis syndrome (Disease Ontology:DOID:0050787); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); Ullrich congenital muscular dystrophy 1C (Disease Ontology:DOID:0060943); Bethlem myopathy 1C (Disease Ontology:DOID:0061200); physical disorder (Disease Ontology:DOID:0080015); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); cleft palate-lateral synechia syndrome (Disease Ontology:DOID:0080313); orofacial cleft 11 (Disease Ontology:DOID:0080404); dystonia 27 (Disease Ontology:DOID:0090050); Axenfeld-Rieger syndrome type 3 (Disease Ontology:DOID:0110122); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); syndromic microphthalmia 6 (Disease Ontology:DOID:0111805); keratoconus (Disease Ontology:DOID:10126); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); esophagitis (Disease Ontology:DOID:11963); otosclerosis (Disease Ontology:DOID:12185); cartilage disease (Disease Ontology:DOID:1222); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); uterine fibroid (Disease Ontology:DOID:13223); fibrodysplasia ossificans progressiva (Disease Ontology:DOID:13374); tuberous sclerosis (Disease Ontology:DOID:13515); peptic esophagitis (Disease Ontology:DOID:13976); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); breast cancer (Disease Ontology:DOID:1612); urinary system disease (Disease Ontology:DOID:18); calcinosis (Disease Ontology:DOID:182); epilepsy (Disease Ontology:DOID:1826); atrial heart septal defect (Disease Ontology:DOID:1882); melanoma (Disease Ontology:DOID:1909); communication disorder (Disease Ontology:DOID:2033); colon cancer (Disease Ontology:DOID:219); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); prolactinoma (Disease Ontology:DOID:5394); strabismus (Disease Ontology:DOID:540); myocardial infarction (Disease Ontology:DOID:5844); myositis ossificans (Disease Ontology:DOID:668); chronic kidney disease (Disease Ontology:DOID:784); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); Barrett's esophagus (Disease Ontology:DOID:9206); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:25296); (R-RNO-2129379); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8373807", "class_list": "", "function": "Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 55, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0001759 organ induction;GO:0060429 epithelium development;GO:1901331 positive regulation of odontoblast differentiation;GO:1901341 positive regulation of store-operated calcium channel activity;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06826-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06BI3-1", "uniprot_id": [ { "id": "CABP8_RAT", "url": "https://www.uniprot.org/uniprot/Q06BI3", "type": "external" } ], "mass": 29625.0, "length": 261, "protein_name": "Calcium-binding protein 8", "gene_name": "Caln1", "organism": "Rat", "refseq_name": "calcium-binding protein 8", "refseq_ac": [ { "id": "NP_001070669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070669", "type": "external" } ], "gene_names_uniprotkb": "Caln1; Cabp8", "gene_names_refseq": "Caln1", "protein_names_uniprotkb": "Calcium-binding protein 8; CaBP8; Calneuron I; Calneuron-1", "protein_names_refseq": "caBP8; calcium-binding protein 8; calneuron I", "tax_id": 10116, "disease": "", "pathway": " (rno:363909)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17055077;19458041;19682431;22688515;26116628", "class_list": "", "function": "Calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking., [RefSeq, PubMed]; Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin. Review article, [RefSeq, PubMed]; NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy, [RefSeq, PubMed]; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning., [UniProtKB, PubMed]; The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent., [RefSeq, PubMed]; These results suggest that CalnI attenuates Ca(2+) channel activity and that its subcellular localization is important for this effect., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06BI2", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060291 long-term synaptic potentiation;GO:0007030 Golgi organization;GO:1990743 protein sialylation;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q06BI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08163-1", "uniprot_id": [ { "id": "CAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q08163", "type": "external" } ], "mass": 51589.0, "length": 474, "protein_name": "Adenylyl cyclase-associated protein 1", "gene_name": "Cap1", "organism": "Rat", "refseq_name": "adenylyl cyclase-associated protein 1", "refseq_ac": [ { "id": "NP_071778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071778", "type": "external" } ], "gene_names_uniprotkb": "Cap1; Cap; Mch1", "gene_names_refseq": "Cap1; Mch1", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein 1; CAP 1", "protein_names_refseq": "CAP 1; CAP, adenylate cyclase-associated protein 1; adenylate cyclase associated protein 1; adenylyl cyclase-associated protein 1; cyclase-associated protein homologue", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:64185); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "24272071;25060335;30682386;34099549;8514780", "class_list": "", "function": "CAP1 binds and activates adenylyl cyclase in mammalian cells., [RefSeq, PubMed]; CAP1 was associated with actin and involved in Schwann cell differentiation and motility after sciatic nerve injury., [RefSeq, PubMed]; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity., [UniProtKB, UniProtKB, UniProtKB]; Hippocampal Cap1 levels is sensitive to different exercise intensities.Highest corticosterone level and lactate production leads to reduction and induction of hippocampal Cap1., [RefSeq, PubMed]; Upregulation of CAP1 protein expression was associated with astrocyte proliferation after the trauma of the central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVS8", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0007015 actin filament organization;GO:0000902 cell morphogenesis;GO:0030036 actin cytoskeleton organization;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08163-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09429-1", "uniprot_id": [ { "id": "ABCC8_RAT", "url": "https://www.uniprot.org/uniprot/Q09429", "type": "external" } ], "mass": 177185.0, "length": 1582, "protein_name": "ATP-binding cassette sub-family C member 8", "gene_name": "Abcc8", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 8 isoform 1", "refseq_ac": [ { "id": "NP_037171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037171", "type": "external" } ], "gene_names_uniprotkb": "Abcc8; Sur1; Sur", "gene_names_refseq": "Abcc8; Sur1; Sur", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 8; Sulfonylurea receptor 1", "protein_names_refseq": "ATP-binding cassette sub-family C member 8 isoform 1; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; sulfonylurea receptor 1; sulphonylurea receptor 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); cardiac arrest (Disease Ontology:DOID:0060319); transient neonatal diabetes mellitus (Disease Ontology:DOID:0060334); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); transient neonatal diabetes mellitus 2 (Disease Ontology:DOID:0061174); familial hyperinsulinemic hypoglycemia 1 (Disease Ontology:DOID:0070219); Parkinsonism (Disease Ontology:DOID:0080855); leucine-sensitive hypoglycemia of infancy (Disease Ontology:DOID:0112262); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); hyperinsulinemic hypoglycemia (Disease Ontology:DOID:13317); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hyperinsulinism (Disease Ontology:DOID:2018); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:25559); (R-RNO-1296025); (R-RNO-422356)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "27560494;28092267;30868916;7716547;8942641", "class_list": "", "function": "Despite its importance in central nervous system (CNS) injuries, sulfonylurea receptor 1 (SUR1) upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury. Publication Status: Online-Only, [RefSeq, PubMed]; Intricate interactions between TMD0, the loop following TMD0, and Kir6.2 near the proposed PIP2 binding site, and where ATP density is observed, suggest SUR1 may contribute to ATP and PIP2 binding to enhance Kir6.2 sensitivity to both. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings suggest that the NF-kappaB, p38 MAPK, and PKC signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Abeta1-42 cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of Alzheimer's disease., [RefSeq, PubMed]; Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O54989;P70532;Q9EQT0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043531 ADP binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008282 inward rectifying potassium channel;GO:0030672 synaptic vesicle membrane;GO:0042383 sarcolemma;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0010043 response to zinc ion;GO:0032496 response to lipopolysaccharide;GO:0050905 neuromuscular process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q09429-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10468-1", "uniprot_id": [ { "id": "B4GN1_RAT", "url": "https://www.uniprot.org/uniprot/Q10468", "type": "external" } ], "mass": 59279.0, "length": 533, "protein_name": "Beta-1,4 N-acetylgalactosaminyltransferase 1", "gene_name": "B4galnt1", "organism": "Rat", "refseq_name": "beta-1,4 N-acetylgalactosaminyltransferase 1", "refseq_ac": [ { "id": "NP_074051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074051", "type": "external" } ], "gene_names_uniprotkb": "B4galnt1; Galgt1; Galgt", "gene_names_refseq": "B4galnt1; GalNAc-T; Galgt1", "protein_names_uniprotkb": "Beta-1,4 N-acetylgalactosaminyltransferase 1; (N-acetylneuraminyl)-galactosylglucosylceramide; 2.4.1.-; 2.4.1.92; GA2 synthase; GD2 synthase; GM2 synthase; GalNAc-T", "protein_names_refseq": "(N-acetylneuraminyl)-galactosylglucosylceramide; GA2 synthase; GM2 synthase; GM2/GD2 synthase; UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)- galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase; beta-1,4 N-acetylgalactosaminyltransferase 1; beta-4N-acetylgalactosaminyltransferase", "tax_id": 10116, "disease": "hereditary spastic paraplegia 26 (Disease Ontology:DOID:0110777)", "pathway": " (rno:64828); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1606358;3140234;7980468", "class_list": "glycogene;glycosyltransferase", "function": "Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.92", "type": "external" } ], "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0007283 spermatogenesis;GO:0060173 limb development;GO:0006687 glycosphingolipid metabolic process;GO:0019915 lipid storage", "synthesized_glycan_count": 72, "hit_score": 0.4, "record_id": "Q10468-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1M168-1", "uniprot_id": [ { "id": "ATCAY_RAT", "url": "https://www.uniprot.org/uniprot/Q1M168", "type": "external" } ], "mass": 42117.0, "length": 372, "protein_name": "Caytaxin", "gene_name": "Atcay", "organism": "Rat", "refseq_name": "caytaxin", "refseq_ac": [ { "id": "NP_001035280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035280", "type": "external" } ], "gene_names_uniprotkb": "Atcay", "gene_names_refseq": "Atcay", "protein_names_uniprotkb": "Caytaxin", "protein_names_refseq": "ATCAY, caytaxin; ataxia, cerebellar, Cayman type; caytaxin", "tax_id": 10116, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); Cayman type cerebellar ataxia (Disease Ontology:DOID:0060694); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:362826)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16246457;16899818;17092653;17157273;18628984;19861499;26343454", "class_list": "", "function": "Atcay mRNA is found in all brain neuronal populations.In cerebellum, it is in the molecular, Purkinje & granular layers. It may have a vital role in the development & neurophysiology of cerebellar cortex., [RefSeq, PubMed]; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites., [UniProtKB, PubMed, PubMed]; Nerve growth factor may stimulate the interaction of BNIP-H with Pin1 by releasing its intramolecular inhibition Publication Status: Online-Only, [RefSeq, PubMed]; Precise targeting of the cholinergic machinery through BNIP-H is essential for the local production of acetylcholine for morphogenesis and neurotransmission, [RefSeq, PubMed]; The above data, disease phenotypes, and mutant animals suggest that Caytaxin may be essential for synaptic function., [RefSeq, PubMed]; The data of this study indicate that caytaxin plays a critical role in the molecular response of Purkinje cells to climbing fiber input. Caytaxin may also contribute to maturational events in cerebellar cortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0006915 apoptotic process;GO:0032880 regulation of protein localization;GO:0048311 mitochondrion distribution;GO:2000212 negative regulation of glutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q1M168-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q30KJ2-1", "uniprot_id": [ { "id": "DFB50_RAT", "url": "https://www.uniprot.org/uniprot/Q30KJ2", "type": "external" } ], "mass": 7900.0, "length": 73, "protein_name": "Beta-defensin 50", "gene_name": "Defb50", "organism": "Rat", "refseq_name": "beta-defensin 50 precursor", "refseq_ac": [ { "id": "NP_001032602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032602", "type": "external" } ], "gene_names_uniprotkb": "Defb50", "gene_names_refseq": "Defb50", "protein_names_uniprotkb": "Beta-defensin 50; BD-50; Defensin, beta 50", "protein_names_refseq": "BD-50; beta-defensin 50 precursor; beta-defensin 50", "tax_id": 10116, "disease": "", "pathway": " (rno:641639)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has bactericidal activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q30KJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KJ2-1", "uniprot_id": [ { "id": "ARSK_RAT", "url": "https://www.uniprot.org/uniprot/Q32KJ2", "type": "external" } ], "mass": 64273.0, "length": 563, "protein_name": "Arylsulfatase K", "gene_name": "Arsk", "organism": "Rat", "refseq_name": "arylsulfatase K precursor", "refseq_ac": [ { "id": "NP_001041382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041382", "type": "external" } ], "gene_names_uniprotkb": "Arsk", "gene_names_refseq": "Arsk; RGD1310182", "protein_names_uniprotkb": "Arylsulfatase K; 3.1.6.18; 3.1.6.1; ASK; Glucuronate-2-sulfatase", "protein_names_refseq": "ASK; arylsulfatase K precursor; arylsulfatase K; glucuronate-2-sulfatase", "tax_id": 10116, "disease": "mucopolysaccharidosis X (Disease Ontology:DOID:0061128); mucopolysaccharidosis (Disease Ontology:DOID:12798)", "pathway": " (rno:365619); (R-RNO-1663150); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16174644", "class_list": "", "function": "Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0015024 glucuronate-2-sulfatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32KJ2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KJ8-1", "uniprot_id": [ { "id": "ARSI_RAT", "url": "https://www.uniprot.org/uniprot/Q32KJ8", "type": "external" } ], "mass": 64424.0, "length": 573, "protein_name": "Arylsulfatase I", "gene_name": "Arsi", "organism": "Rat", "refseq_name": "arylsulfatase I precursor", "refseq_ac": [ { "id": "NP_001041346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041346", "type": "external" } ], "gene_names_uniprotkb": "Arsi", "gene_names_refseq": "Arsi; RGD1310242", "protein_names_uniprotkb": "Arylsulfatase I; 3.1.6.-; ASI", "protein_names_refseq": "ASI; arylsulfatase I precursor; arylsulfatase i", "tax_id": 10116, "disease": "", "pathway": " (rno:307404); (R-RNO-1663150); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16174644", "class_list": "", "function": "Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32KJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32KJ9-1", "uniprot_id": [ { "id": "ARSG_RAT", "url": "https://www.uniprot.org/uniprot/Q32KJ9", "type": "external" } ], "mass": 57269.0, "length": 526, "protein_name": "Arylsulfatase G", "gene_name": "Arsg", "organism": "Rat", "refseq_name": "arylsulfatase G precursor", "refseq_ac": [ { "id": "NP_001041342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041342", "type": "external" } ], "gene_names_uniprotkb": "Arsg", "gene_names_refseq": "Arsg; RGD1306571", "protein_names_uniprotkb": "Arylsulfatase G; 3.1.6.15; 3.1.6.1; ASG; N-sulfoglucosamine-3-sulfatase", "protein_names_refseq": "ASG; N-sulfoglucosamine-3-sulfatase; arylsulfatase G precursor", "tax_id": 10116, "disease": "Usher syndrome (Disease Ontology:DOID:0050439); mucopolysaccharidosis (Disease Ontology:DOID:12798)", "pathway": " (rno:303631); (R-RNO-1663150); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16174644", "class_list": "", "function": "Displays arylsulfatase activity at acidic pH towards the artificial substrate p-nitrocatechol sulfate (By similarity). Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0033889 N-sulfoglucosamine-3-sulfatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0060041 retina development in camera-type eye;GO:0007040 lysosome organization;GO:0006790 sulfur compound metabolic process;GO:0048872 homeostasis of number of cells", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32KJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32WR5-1", "uniprot_id": [ { "id": "BL1S2_RAT", "url": "https://www.uniprot.org/uniprot/Q32WR5", "type": "external" } ], "mass": 16067.0, "length": 142, "protein_name": "Biogenesis of lysosome-related organelles complex-1 subunit 2", "gene_name": "Bloc1s2", "organism": "Rat", "refseq_name": "biogenesis of lysosome-related organelles complex-1 subunit 2", "refseq_ac": [ { "id": "NP_001032426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032426", "type": "external" } ], "gene_names_uniprotkb": "Bloc1s2; Rsep1; Sep1", "gene_names_refseq": "Bloc1s2; RSEP1; Sep1", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex-1 subunit 2; BLOC-1 subunit 2; Spinal cord-expressed protein 1", "protein_names_refseq": "BLOC-1 subunit 2; biogenesis of lysosome-related organelles complex-1 subunit 2; spinal cord-expressed protein 1", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (rno:293938)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16176350;17552904;20308062;29393594", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation., [UniProtKB, UniProtKB, UniProtKB]; In search of novel interaction partners of AATF, we identified BLOS2 (BLOC1S2, also termed Ceap) from a rat cDNA library; BLOS2 is extremely conserved with a high degree of homology to yeast She3p., [RefSeq, PubMed]; Rat spinal cord expression protein 1 is a novel gene with functional involvement in neuropathic pain behaviour., [RefSeq, PubMed]; WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0031175 neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q32WR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32ZF3-1", "uniprot_id": [ { "id": "DFB43_RAT", "url": "https://www.uniprot.org/uniprot/Q32ZF3", "type": "external" } ], "mass": 8329.0, "length": 70, "protein_name": "Beta-defensin 43", "gene_name": "Defb43", "organism": "Rat", "refseq_name": "beta-defensin 43 precursor", "refseq_ac": [ { "id": "NP_001032617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032617", "type": "external" } ], "gene_names_uniprotkb": "Defb43", "gene_names_refseq": "BD-43; 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Dullard", "gene_names_refseq": "Ctdnep1; Dullard", "protein_names_uniprotkb": "CTD nuclear envelope phosphatase 1; 3.1.3.16; Serine/threonine-protein phosphatase dullard", "protein_names_refseq": "CTD nuclear envelope phosphatase 1; serine/threonine-protein phosphatase dullard", "tax_id": 10116, "disease": "", "pathway": " (rno:287447); (R-RNO-4419969)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M952", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0034504 protein localization to nucleus;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006998 nuclear envelope organization;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7T6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR54-1", "uniprot_id": [ { "id": "ADAD1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR54", "type": "external" } ], "mass": 67816.0, "length": 619, "protein_name": "Adenosine deaminase domain-containing protein 1", "gene_name": "Adad1", "organism": "Rat", "refseq_name": "adenosine deaminase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001006978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006978", "type": "external" } ], "gene_names_uniprotkb": "Adad1; Tenr", "gene_names_refseq": "Adad1; Tenr", "protein_names_uniprotkb": "Adenosine deaminase domain-containing protein 1; Testis nuclear RNA-binding protein", "protein_names_refseq": "adenosine deaminase domain containing 1 (testis specific); adenosine deaminase domain-containing protein 1; testis nuclear RNA-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:294979)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for male fertility and normal male germ cell differentiation (By similarity). Plays a role in spermatogenesis (By similarity). Binds to RNA but not to DNA (By similarity)., [UniProtKB, UniProtKB]; Required for male fertility and normal male germ cell differentiation. Plays a role in spermatogenesis. Binds to RNA but not to DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0003725 double-stranded RNA binding;GO:0003726 double-stranded RNA adenosine deaminase activity;GO:0004000 adenosine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006396 RNA processing;GO:0007286 spermatid development;GO:0006382 adenosine to inosine editing;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3KR54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR97-1", "uniprot_id": [ { "id": "BI2L1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR97", "type": "external" } ], "mass": 57468.0, "length": 516, "protein_name": "BAR/IMD domain-containing adapter protein 2-like 1", "gene_name": "Baiap2l1", "organism": "Rat", "refseq_name": "BAR/IMD domain-containing adapter protein 2-like 1", "refseq_ac": [ { "id": "NP_001029312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029312", "type": "external" } ], "gene_names_uniprotkb": "Baiap2l1", "gene_names_refseq": "Baiap2l1; RGD1308452", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 1; BAI1-associated protein 2-like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1", "protein_names_refseq": "BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304282); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWT2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRE0-1", "uniprot_id": [ { "id": "ATD3A_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRE0", "type": "external" } ], "mass": 66759.0, "length": 591, "protein_name": "ATPase family AAA domain-containing protein 3A", "gene_name": "Atad3a", "organism": "Rat", "refseq_name": "ATPase family AAA domain-containing protein 3A", "refseq_ac": [ { "id": "NP_001030094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030094", "type": "external" } ], "gene_names_uniprotkb": "Atad3a; Atad3", "gene_names_refseq": "Atad3a; Atad3", "protein_names_uniprotkb": "ATPase family AAA domain-containing protein 3A; 3.6.1.-", "protein_names_refseq": "ATPase family AAA domain-containing protein 3A; ATPase family AAA domain-containing protein 3", "tax_id": 10116, "disease": "Harel-Yoon syndrome (Disease Ontology:DOID:0081395); neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome (Disease Ontology:DOID:0081396)", "pathway": " (rno:298682); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17210950;20351179;25375035;28100784;38843836", "class_list": "", "function": "Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR)., [UniProtKB, UniProtKB]; These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0001558 regulation of cell growth;GO:0007005 mitochondrion organization;GO:1903898 negative regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3KRE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRF3-1", "uniprot_id": [ { "id": "FSAF1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRF3", "type": "external" } ], "mass": 31829.0, "length": 282, "protein_name": "40S small subunit processome assembly factor 1", "gene_name": "Fsaf1", "organism": "Rat", "refseq_name": "40S small subunit processome assembly factor 1", "refseq_ac": [ { "id": "NP_001030091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030091", "type": "external" } ], "gene_names_uniprotkb": "Fsaf1; C19h1orf131", "gene_names_refseq": "C19h1orf131; Fsaf1; RGD1562218", "protein_names_uniprotkb": "40S small subunit processome assembly factor 1", "protein_names_refseq": "40S small subunit processome assembly factor 1; uncharacterized protein C1orf131 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292100)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Prevents helicase DHX37 to be recruited before post-A1 state., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005694 chromosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3KRF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MID3-1", "uniprot_id": [ { "id": "ARFG2_RAT", "url": "https://www.uniprot.org/uniprot/Q3MID3", "type": "external" } ], "mass": 56556.0, "length": 520, "protein_name": "ADP-ribosylation factor GTPase-activating protein 2", "gene_name": "Arfgap2", "organism": "Rat", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 2", "refseq_ac": [ { "id": "NP_001028879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028879", "type": "external" } ], "gene_names_uniprotkb": "Arfgap2; Zfp289; Znf289", "gene_names_refseq": "Arfgap2; Zfp289", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; GTPase-activating protein ZNF289; Zinc finger protein 289", "protein_names_refseq": "ADP-ribosylation factor GTPase activating protein 2; ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; GTPase-activating protein ZNF289; zinc finger protein 289", "tax_id": 10116, "disease": "", "pathway": " (rno:362162); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19015319;22673903", "class_list": "", "function": "Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking, [RefSeq, PubMed]; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MID3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MKQ1-1", "uniprot_id": [ { "id": "BEX2_RAT", "url": "https://www.uniprot.org/uniprot/Q3MKQ1", "type": "external" } ], "mass": 15541.0, "length": 129, "protein_name": "Protein BEX2", "gene_name": "Bex2", "organism": "Rat", "refseq_name": "protein BEX1", "refseq_ac": [ { "id": "NP_001070903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070903", "type": "external" } ], "gene_names_uniprotkb": "Bex2", "gene_names_refseq": "Bex1; Bex22; Bex2; EG2RVC", "protein_names_uniprotkb": "Protein BEX2; Brain-expressed X-linked protein 2 homolog", "protein_names_refseq": "brain expressed X-linked 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; expression gene 2 in rat visual cortex; protein BEX1; protein BEX2", "tax_id": 10116, "disease": "", "pathway": " (rno:363498)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15958283", "class_list": "", "function": "Regulator of mitochondrial apoptosis and G1 cell cycle. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0035591 signaling adaptor activity;GO:0001223 transcription coactivator binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007165 signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MKQ1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1G7-1", "uniprot_id": [ { "id": "COG7_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1G7", "type": "external" } ], "mass": 86212.0, "length": 770, "protein_name": "Conserved oligomeric Golgi complex subunit 7", "gene_name": "Cog7", "organism": "Rat", "refseq_name": "conserved oligomeric Golgi complex subunit 7", "refseq_ac": [ { "id": "NP_001029061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029061", "type": "external" } ], "gene_names_uniprotkb": "Cog7", "gene_names_refseq": "Cog7", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 7; COG complex subunit 7; Component of oligomeric Golgi complex 7", "protein_names_refseq": "COG complex subunit 7; conserved oligomeric Golgi complex subunit 7", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIe (Disease Ontology:DOID:0070257); genetic disease (Disease Ontology:DOID:630)", "pathway": " (rno:293456); (R-RNO-6807878); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0009101 glycoprotein biosynthetic process;GO:0050821 protein stabilization;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1G7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZCQ0-1", "uniprot_id": [ { "id": "RDD1_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZCQ0", "type": "external" } ], "mass": 15343.0, "length": 140, "protein_name": "Required for drug-induced death protein 1", "gene_name": "C13h1orf115", "organism": "Rat", "refseq_name": "required for drug-induced death protein 1", "refseq_ac": [ { "id": "NP_001094327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094327", "type": "external" } ], "gene_names_uniprotkb": "C13h1orf115; RGD1310587", "gene_names_refseq": "C13h1orf115; RGD1310587", "protein_names_uniprotkb": "Required for drug-induced death protein 1", "protein_names_refseq": "required for drug-induced death protein 1; uncharacterized protein C1orf115 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360894)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates drug efflux through modulation of ABCB1 localization and activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:2001023 regulation of response to drug", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZCQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q400C9-1", "uniprot_id": [ { "id": "AMZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q400C9", "type": "external" } ], "mass": 55323.0, "length": 501, "protein_name": "Archaemetzincin-1", "gene_name": "Amz1", "organism": "Rat", "refseq_name": "archaemetzincin-1", "refseq_ac": [ { "id": "NP_001040557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040557", "type": "external" } ], "gene_names_uniprotkb": "Amz1", "gene_names_refseq": "Amz1; RGD1311314", "protein_names_uniprotkb": "Archaemetzincin-1; 3.4.-.-; Archeobacterial metalloproteinase-like protein 1", "protein_names_refseq": "archaemetzincin-1; archeobacterial metalloproteinase-like 1; archeobacterial metalloproteinase-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15972818", "class_list": "", "function": "Probable zinc metalloprotease., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1H214", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q400C9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499N5-1", "uniprot_id": [ { "id": "ACSF2_RAT", "url": "https://www.uniprot.org/uniprot/Q499N5", "type": "external" } ], "mass": 67886.0, "length": 615, "protein_name": "Medium-chain acyl-CoA ligase ACSF2, mitochondrial", "gene_name": "Acsf2", "organism": "Rat", "refseq_name": "medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001030123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030123", "type": "external" } ], "gene_names_uniprotkb": "Acsf2", "gene_names_refseq": "Acsf2", "protein_names_uniprotkb": "Medium-chain acyl-CoA ligase ACSF2, mitochondrial; 6.2.1.2", "protein_names_refseq": "acyl-CoA synthetase family member 2, mitochondrial; medium-chain acyl-CoA ligase ACSF2, mitochondrial precursor; medium-chain acyl-CoA ligase ACSF2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:619561); (R-RNO-77289)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "26446791;27213235;34502162", "class_list": "", "function": "Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031956 medium-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q499N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499P3-1", "uniprot_id": [ { "id": "C1GLC_RAT", "url": "https://www.uniprot.org/uniprot/Q499P3", "type": "external" } ], "mass": 36035.0, "length": 316, "protein_name": "C1GALT1-specific chaperone 1", "gene_name": "C1galt1c1", "organism": "Rat", "refseq_name": "C1GALT1-specific chaperone 1", "refseq_ac": [ { "id": "NP_001025204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025204", "type": "external" } ], "gene_names_uniprotkb": "C1galt1c1", "gene_names_refseq": "C1galt1c1; RGD1311230", "protein_names_uniprotkb": "C1GALT1-specific chaperone 1", "protein_names_refseq": "C1GALT1-specific chaperone 1; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2", "tax_id": 10116, "disease": "Tn polyagglutination syndrome (Disease Ontology:DOID:0080520); hemolytic-uremic syndrome (Disease Ontology:DOID:12554)", "pathway": " (rno:302499); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12464682", "class_list": "glycogene;glycosyltransferase", "function": "Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0030168 platelet activation;GO:0036344 platelet morphogenesis", "synthesized_glycan_count": 3300, "hit_score": 0.2, "record_id": "Q499P3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4AE70-1", "uniprot_id": [ { "id": "CARM1_RAT", "url": "https://www.uniprot.org/uniprot/Q4AE70", "type": "external" } ], "mass": 70341.0, "length": 651, "protein_name": "Histone-arginine methyltransferase CARM1", "gene_name": "Carm1; Timm29", "organism": "Rat", "refseq_name": "histone-arginine methyltransferase CARM1 isoform a", "refseq_ac": [ { "id": "NP_001025212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025212", "type": "external" } ], "gene_names_uniprotkb": "Carm1; Timm29; Prmt4", "gene_names_refseq": "Carm1; Prmt4", "protein_names_uniprotkb": "Histone-arginine methyltransferase CARM1; 2.1.1.319; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4", "protein_names_refseq": "histone-arginine methyltransferase CARM1 isoform a; histone-arginine methyltransferase CARM1; protein arginine N-methyltransferase 4", "tax_id": 10116, "disease": "hepatocellular adenoma (Disease Ontology:DOID:0050868); estrogen-receptor positive breast cancer (Disease Ontology:DOID:0060075); asthma (Disease Ontology:DOID:2841); hepatocellular carcinoma (Disease Ontology:DOID:684); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:315463); (rno:363026); (R-RNO-3214858); (R-RNO-400206); (R-RNO-9018519); (R-RNO-9707564)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "15944154;16508003;17882262;18683930;24726896;25072916;28264928;29393594;31627895;33415686;38843836", "class_list": "", "function": "Blocking the Spinal Fbxo3/CARM1/K(+) Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief., [RefSeq, PubMed]; High-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation, [RefSeq, PubMed]; Isoform 3 specifically affects pre-mRNA splicing (PubMed:15944154). This activity is independent from methyltransferase activity (PubMed:15944154)., [UniProtKB, PubMed]; Mechanistically, PRMT4 overexpression promoted hypoxia-induced cardiomyocytes apoptosis, while its inhibition abolished these effects., [RefSeq, PubMed]; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:16508003). Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activation of transcription via chromatin remodeling (By similarity). During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription (By similarity). During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C (By similarity). During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B (By similarity). Acts as a coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue (By similarity). Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors (By similarity). Also seems to be involved in p53/TP53 transcriptional activation (By similarity). Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation (By similarity). Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs (PubMed:16508003). Acts as a transcriptional coactivator of ACACA/acetyl-CoA carboxylase by enriching H3R17 methylation at its promoter, thereby positively regulating fatty acid synthesis (By similarity). Independently of its methyltransferase activity, involved in replication fork progression: promotes PARP1 recruitment to replication forks, leading to poly-ADP-ribosylation of chromatin at replication forks and reduced fork speed (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The silencing of CARM1 using siRNA increased Notch1 expression, the transcriptional activity of Hes, and podocyte apoptosis., [RefSeq, PubMed]; These results suggest that CARM1 is a post-synaptic protein that plays roles in dendritic maturation and synaptic formation and that spatiotemporal regulation of CARM1 activity modulates neuronal connectivity and improves synaptic dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4AE68;Q4AE69;Q4AE71", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000976 transcription cis-regulatory region binding;GO:0008276 protein methyltransferase activity;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008284 positive regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q4AE70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4JEI2-1", "uniprot_id": [ { "id": "DFAL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4JEI2", "type": "external" } ], "mass": 9702.0, "length": 87, "protein_name": "Defensin alpha-like protein 1", "gene_name": "Defal1", "organism": "Rat", "refseq_name": "defensin alpha-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001028245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028245", "type": "external" } ], "gene_names_uniprotkb": "Defal1; Defa-rs1", "gene_names_refseq": "Defa-rs1; Defal1", "protein_names_uniprotkb": "Defensin alpha-like protein 1; Defensin alpha-related sequence 1; Rattusin", "protein_names_refseq": "alpha-defensin-related sequence 1; defensin alpha-like protein 1 precursor; defensin alpha-like protein 1; defensin alpha-related sequence 1; rattusin", "tax_id": 10116, "disease": "", "pathway": " (rno:613220); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15494476;23380721;28345637;29454031", "class_list": "", "function": "Intestinal defense peptide (PubMed:23380721, PubMed:28345637). Has potent antibacterial activity against Gram-negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin-resistant S.aureus and L.monocytogenes (PubMed:23380721, PubMed:28345637). Remains active in the presence of NaCl and Mg(2+) (PubMed:23380721). Probably functions by disrupting bacterial membrane integrity (PubMed:28345637). However, does not show cytotoxic activity towards human intestinal cells (PubMed:23380721)., [UniProtKB, PubMed, PubMed]; The primary sequence of linear rattusin (Defal1) is composed of 31 amino acids containing five cysteines with a unique spacing pattern., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4JEI2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLY2-1", "uniprot_id": [ { "id": "FBX46_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLY2", "type": "external" } ], "mass": 65239.0, "length": 603, "protein_name": "F-box only protein 46", "gene_name": "Fbxo46", "organism": "Rat", "refseq_name": "F-box only protein 46", "refseq_ac": [ { "id": "NP_001020813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020813", "type": "external" } ], "gene_names_uniprotkb": "Fbxo46", "gene_names_refseq": "Fbxo46", "protein_names_uniprotkb": "F-box only protein 46", "protein_names_refseq": "F-box only protein 46", "tax_id": 10116, "disease": "", "pathway": " (rno:292686)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of the SCF(FBXO46) protein ligase complex, which mediates the ubiquitination and degradation of target proteins. In absence of stress, the SCF(FBXO46) complex catalyzes ubiquitination and degradation of MTOR-phosphorylated FBXO31., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM30-1", "uniprot_id": [ { "id": "DESI1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM30", "type": "external" } ], "mass": 18385.0, "length": 168, "protein_name": "Desumoylating isopeptidase 1", "gene_name": "Desi1", "organism": "Rat", "refseq_name": "desumoylating isopeptidase 1", "refseq_ac": [ { "id": "NP_001020874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020874", "type": "external" } ], "gene_names_uniprotkb": "Desi1; Fam152b; Pppde2", "gene_names_refseq": "DeSI-1; Desi1; Fam152b; Pppde2; RGD1305776", "protein_names_uniprotkb": "Desumoylating isopeptidase 1; 3.1.2.22; 3.4.-.-; DeSI-1; PPPDE peptidase domain-containing protein 2; Palmitoyl protein thioesterase DESI1; S-depalmitoylase DESI1", "protein_names_refseq": "PPPDE peptidase domain containing 2; PPPDE peptidase domain-containing protein 2; S-depalmitoylase DESI1; desumoylating isopeptidase 1; family with sequence similarity 152, member B; palmitoyl protein thioesterase DESI1", "tax_id": 10116, "disease": "", "pathway": " (rno:315160)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0061676 importin-alpha family protein binding;GO:0042802 identical protein binding;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006611 protein export from nucleus;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQT4-1", "uniprot_id": [ { "id": "2AAB_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQT4", "type": "external" } ], "mass": 66006.0, "length": 601, "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "Ppp2r1b", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "refseq_ac": [ { "id": "NP_001020589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020589", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r1b", "gene_names_refseq": "Ppp2r1b", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta", "protein_names_refseq": "protein phosphatase 2, regulatory subunit A, beta; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "tax_id": 10116, "disease": "lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:315648); (R-RNO-113501); (R-RNO-141430); (R-RNO-141444); (R-RNO-180024); (R-RNO-195253); (R-RNO-196299); (R-RNO-198753); (R-RNO-202670); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-389356); (R-RNO-389513); (R-RNO-432142); (R-RNO-4641262); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-5675221); (R-RNO-6804757); (R-RNO-6811558); (R-RNO-68877); (R-RNO-69231); (R-RNO-69273); (R-RNO-9648025); (R-RNO-9833482); (R-RNO-9860927)", "pathway_count": 26, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0060561 apoptotic process involved in morphogenesis;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQT4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQV7-1", "uniprot_id": [ { "id": "CH25H_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQV7", "type": "external" } ], "mass": 34414.0, "length": 298, "protein_name": "Cholesterol 25-hydroxylase", "gene_name": "Ch25h", "organism": "Rat", "refseq_name": "cholesterol 25-hydroxylase", "refseq_ac": [ { "id": "NP_001020586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020586", "type": "external" } ], "gene_names_uniprotkb": "Ch25h", "gene_names_refseq": "Ch25h", "protein_names_uniprotkb": "Cholesterol 25-hydroxylase; 1.14.99.38; Cholesterol 25-monooxygenase", "protein_names_refseq": "cholesterol 25-hydroxylase; cholesterol 25-monooxygenase", "tax_id": 10116, "disease": "", "pathway": " (rno:309527); (R-RNO-192105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11207193;11967195;12390873;38331303", "class_list": "", "function": "Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:11207193, PubMed:11967195). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (PubMed:11207193, PubMed:11967195). Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity). Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.99.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.38", "type": "external" } ], "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding;GO:0008395 steroid hydroxylase activity;GO:0001567 cholesterol 25-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0016126 sterol biosynthetic process;GO:0035754 B cell chemotaxis;GO:0034340 response to type I interferon;GO:1903914 negative regulation of fusion of virus membrane with host plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QQV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQW5-1", "uniprot_id": [ { "id": "CCNQ_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQW5", "type": "external" } ], "mass": 28947.0, "length": 250, "protein_name": "Cyclin-Q", "gene_name": "Ccnq", "organism": "Rat", "refseq_name": "cyclin-Q", "refseq_ac": [ { "id": "NP_001020583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020583", "type": "external" } ], "gene_names_uniprotkb": "Ccnq; Fam58a", "gene_names_refseq": "Ccnq; Fam58a; Fam58b; RGD1305651", "protein_names_uniprotkb": "Cyclin-Q; CDK10-activating cyclin; Cyclin-M; Cyclin-related protein FAM58A", "protein_names_refseq": "CDK10-activating cyclin; cyclin-M; cyclin-Q; cyclin-related protein FAM58A; family with sequence similarity 58, member B", "tax_id": 10116, "disease": "syndactyly-telecanthus-anogenital and renal malformations syndrome (Disease Ontology:DOID:0111931)", "pathway": " (rno:303321)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activating cyclin for the cyclin-associated kinase CDK10., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJY7", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043410 positive regulation of MAPK cascade;GO:1902749 regulation of cell cycle G2/M phase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQW5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7C4-1", "uniprot_id": [ { "id": "CCD71_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7C4", "type": "external" } ], "mass": 46462.0, "length": 436, "protein_name": "Coiled-coil domain-containing protein 71", "gene_name": "Ccdc71", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 71", "refseq_ac": [ { "id": "NP_001020075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020075", "type": "external" } ], "gene_names_uniprotkb": "Ccdc71", "gene_names_refseq": "Ccdc71", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 71", "protein_names_refseq": "coiled-coil domain-containing protein 71", "tax_id": 10116, "disease": "", "pathway": " (rno:498678)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7C4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V897-1", "uniprot_id": [ { "id": "CC90B_RAT", "url": "https://www.uniprot.org/uniprot/Q4V897", "type": "external" } ], "mass": 29800.0, "length": 256, "protein_name": "Coiled-coil domain-containing protein 90B, mitochondrial", "gene_name": "Ccdc90b", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 90B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001020056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020056", "type": "external" } ], "gene_names_uniprotkb": "Ccdc90b", "gene_names_refseq": "Ccdc90b; RGD1308637", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 90B, mitochondrial", "protein_names_refseq": "coiled-coil domain-containing protein 90B, mitochondrial precursor; coiled-coil domain-containing protein 90B, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:308820)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V897-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8E4-1", "uniprot_id": [ { "id": "CFA36_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8E4", "type": "external" } ], "mass": 39590.0, "length": 343, "protein_name": "Cilia- and flagella-associated protein 36", "gene_name": "Cfap36", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 36", "refseq_ac": [ { "id": "NP_001020037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020037", "type": "external" } ], "gene_names_uniprotkb": "Cfap36; Ccdc104", "gene_names_refseq": "Ccdc104; Cfap36; RGD1311732", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 36; Coiled-coil domain-containing protein 104", "protein_names_refseq": "cilia- and flagella-associated protein 36; coiled-coil domain containing 104; coiled-coil domain-containing protein 104", "tax_id": 10116, "disease": "", "pathway": " (rno:289859)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19680650;22673903", "class_list": "", "function": "May act as an effector for ARL3., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031514 motile cilium;GO:0005930 axoneme;GO:0097546 ciliary base;GO:0035869 ciliary transition zone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V8E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8F1-1", "uniprot_id": [ { "id": "CC184_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8F1", "type": "external" } ], "mass": 20390.0, "length": 193, "protein_name": "Coiled-coil domain-containing protein 184", "gene_name": "Ccdc184", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 184", "refseq_ac": [ { "id": "NP_001020080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020080", "type": "external" } ], "gene_names_uniprotkb": "Ccdc184", "gene_names_refseq": "Ccdc184", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 184", "protein_names_refseq": "coiled-coil domain-containing protein 184; uncharacterized protein C12orf68 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500925)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8F1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8I4-1", "uniprot_id": [ { "id": "DEFI8_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8I4", "type": "external" } ], "mass": 52697.0, "length": 451, "protein_name": "Differentially expressed in FDCP 8 homolog", "gene_name": "Def8", "organism": "Rat", "refseq_name": "differentially expressed in FDCP 8 homolog", "refseq_ac": [ { "id": "NP_001019945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019945", "type": "external" } ], "gene_names_uniprotkb": "Def8", "gene_names_refseq": "Def8", "protein_names_uniprotkb": "Differentially expressed in FDCP 8 homolog; DEF-8", "protein_names_refseq": "DEF-8; differentially expressed in FDCP 8 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307973)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0045780 positive regulation of bone resorption;GO:0032418 lysosome localization;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8I5-1", "uniprot_id": [ { "id": "AR6P4_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8I5", "type": "external" } ], "mass": 25769.0, "length": 231, "protein_name": "ADP-ribosylation factor-like protein 6-interacting protein 4", "gene_name": "Arl6ip4", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 6-interacting protein 4", "refseq_ac": [ { "id": "NP_001020801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020801", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip4", "gene_names_refseq": "Arl6ip4", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6-interacting protein 4; ARL-6-interacting protein 4; Aip-4; Splicing factor SRrp37", "protein_names_refseq": "ADP-ribosylation factor like GTPase 6 interacting protein 4; ADP-ribosylation factor-like 6 interacting protein 4; ADP-ribosylation factor-like protein 6-interacting protein 4; ADP-ribosylation-like factor 6 interacting protein 4; ARL-6-interacting protein 4; aip-4; splicing factor SRrp37", "tax_id": 10116, "disease": "", "pathway": " (rno:288656)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499T6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8I5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R8-1", "uniprot_id": [ { "id": "CAHM6_RAT", "url": "https://www.uniprot.org/uniprot/Q561R8", "type": "external" } ], "mass": 34730.0, "length": 315, "protein_name": "Calcium homeostasis modulator protein 6", "gene_name": "Calhm6", "organism": "Rat", "refseq_name": "calcium homeostasis modulator protein 6", "refseq_ac": [ { "id": "NP_001020147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020147", "type": "external" } ], "gene_names_uniprotkb": "Calhm6; Fam26f", "gene_names_refseq": "Calhm6; Fam26f; RGD1304835", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 6; Protein FAM26F", "protein_names_refseq": "calcium homeostasis modulator protein 6; family with sequence similarity 26, member F; protein FAM26F", "tax_id": 10116, "disease": "", "pathway": " (rno:294430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Pore-forming subunit of an ATP-permeable channel. In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0022832 voltage-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001772 immunological synapse", "go_biological_process": "GO:1904669 ATP export;GO:0002727 regulation of natural killer cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q561R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562C2-1", "uniprot_id": [ { "id": "BOP1_RAT", "url": "https://www.uniprot.org/uniprot/Q562C2", "type": "external" } ], "mass": 82640.0, "length": 731, "protein_name": "Ribosome biogenesis protein BOP1", "gene_name": "Bop1", "organism": "Rat", "refseq_name": "ribosome biogenesis protein BOP1", "refseq_ac": [ { "id": "NP_001019421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019421", "type": "external" } ], "gene_names_uniprotkb": "Bop1", "gene_names_refseq": "Bop1", "protein_names_uniprotkb": "Ribosome biogenesis protein BOP1; Block of proliferation 1 protein", "protein_names_refseq": "block of proliferation 1 protein; ribosome biogenesis protein BOP1", "tax_id": 10116, "disease": "", "pathway": " (rno:300050); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0006364 rRNA processing;GO:0000460 maturation of 5.8S rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q562C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Z7-1", "uniprot_id": [ { "id": "CIB2_RAT", "url": "https://www.uniprot.org/uniprot/Q568Z7", "type": "external" } ], "mass": 21672.0, "length": 187, "protein_name": "Calcium and integrin-binding family member 2", "gene_name": "Cib2", "organism": "Rat", "refseq_name": "calcium and integrin-binding family member 2", "refseq_ac": [ { "id": "NP_001015010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015010", "type": "external" } ], "gene_names_uniprotkb": "Cib2", "gene_names_refseq": "Cib2", "protein_names_uniprotkb": "Calcium and integrin-binding family member 2", "protein_names_refseq": "calcium and integrin-binding family member 2", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 48 (Disease Ontology:DOID:0110505)", "pathway": " (rno:300719)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19433056;28663585", "class_list": "", "function": "CaMy2 binds Ca2+ and exhibits Ca2+/conformational switch. Moreover, CaMy2 undergoes N-myristoylation without Ca2+/myristoyl switch, is membrane-associated and localizes in neurons together with Golgi apparatus and dendrite markers., [RefSeq, PubMed]; Calcium- and integrin-binding protein that plays a role in intracellular calcium homeostasis (By similarity). Acts as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells (By similarity). Essential for mechanoelectrical transduction (MET) currents in auditory hair cells and thereby required for hearing (By similarity). Regulates the function of hair cell mechanotransduction by controlling the distribution of transmembrane channel-like proteins TMC1 and TMC2, and by regulating the function of the MET channels in hair cells (By similarity). Required for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). Critical for proper photoreceptor cell maintenance and function (By similarity). Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0001917 photoreceptor inner segment;GO:0071944 cell periphery", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045494 photoreceptor cell maintenance;GO:0055074 calcium ion homeostasis;GO:0071318 cellular response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q568Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJM7-1", "uniprot_id": [ { "id": "C42S1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJM7", "type": "external" } ], "mass": 8967.0, "length": 79, "protein_name": "CDC42 small effector protein 1", "gene_name": "Cdc42se1", "organism": "Rat", "refseq_name": "CDC42 small effector protein 1", "refseq_ac": [ { "id": "NP_001034133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034133", "type": "external" } ], "gene_names_uniprotkb": "Cdc42se1", "gene_names_refseq": "Cdc42se1", "protein_names_uniprotkb": "CDC42 small effector protein 1", "protein_names_refseq": "CDC42 small effector protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:499672)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006909 phagocytosis;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJT0-1", "uniprot_id": [ { "id": "ARGL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJT0", "type": "external" } ], "mass": 32887.0, "length": 271, "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "Arglu1", "organism": "Rat", "refseq_name": "arginine and glutamate-rich protein 1", "refseq_ac": [ { "id": "NP_001020143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020143", "type": "external" } ], "gene_names_uniprotkb": "Arglu1", "gene_names_refseq": "Arglu1; RGD1310061", "protein_names_uniprotkb": "Arginine and glutamate-rich protein 1", "protein_names_refseq": "arginine and glutamate-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290912)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1. Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (By similarity). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (By similarity). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (By similarity). May also indirectly modulate alternative splicing (By similarity). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization. Regulates splicing of genes involved in neurogenesis and chromatin organization. Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPJ8", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJU5-1", "uniprot_id": [ { "id": "CNIH2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJU5", "type": "external" } ], "mass": 18931.0, "length": 160, "protein_name": "Protein cornichon homolog 2", "gene_name": "Cnih2", "organism": "Rat", "refseq_name": "protein cornichon homolog 2", "refseq_ac": [ { "id": "NP_001020303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020303", "type": "external" } ], "gene_names_uniprotkb": "Cnih2", "gene_names_refseq": "CNIH-2; Cnih2; Cnih3; RGD1304930", "protein_names_uniprotkb": "Protein cornichon homolog 2; CNIH-2; Cornichon family AMPA receptor auxiliary protein 2; Cornichon-like protein", "protein_names_refseq": "cornichon homolog 2; cornichon homolog 3; cornichon-like protein; protein cornichon homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361705); (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19265014;20805473;21543622;22292017", "class_list": "", "function": "CNIH-2 modulates neuronal AMPA receptor auxiliary subunit assembly by regulating the number of transmembrane AMPA receptor regulatory proteins within an AMPA receptor complex to modulate receptor gating and pharmacology., [RefSeq, PubMed]; Findings show that the majority of AMPARs in the brain are coassembled with CNIH-2 & CNIH-3; cornichons increase surface expression of AMPARs, & alter channel gating by markedly slowing deactivation & desensitization kinetics, [RefSeq, PubMed]; Mammalian AMPARs commandeer CNIH-2 for use as a bona fide auxiliary subunit that is able to modify receptor signaling., [RefSeq, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:2000310 regulation of NMDA receptor activity;GO:0035249 synaptic transmission, glutamatergic;GO:0016192 vesicle-mediated transport;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5BJU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJZ0-1", "uniprot_id": [ { "id": "CAST1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJZ0", "type": "external" } ], "mass": 36476.0, "length": 331, "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "Castor1", "organism": "Rat", "refseq_name": "cytosolic arginine sensor for mTORC1 subunit 1", "refseq_ac": [ { "id": "NP_001020299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020299", "type": "external" } ], "gene_names_uniprotkb": "Castor1; Gatsl3", "gene_names_refseq": "Castor1; Gatsl3; RGD1304774", "protein_names_uniprotkb": "Cytosolic arginine sensor for mTORC1 subunit 1; GATS-like protein 3", "protein_names_refseq": "GATS protein-like 3; GATS-like protein 3; Gats protein; cytosolic arginine sensor for mTORC1 subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360969); (R-RNO-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034618 arginine binding;GO:0140299 molecular sensor activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005829 cytosol;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0034198 cellular response to amino acid starvation;GO:1903577 cellular response to L-arginine;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK10-1", "uniprot_id": [ { "id": "CAN13_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK10", "type": "external" } ], "mass": 76939.0, "length": 668, "protein_name": "Calpain-13", "gene_name": "Capn13", "organism": "Rat", "refseq_name": "calpain-13", "refseq_ac": [ { "id": "NP_001020304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020304", "type": "external" } ], "gene_names_uniprotkb": "Capn13", "gene_names_refseq": "CANP 13; Capn13", "protein_names_uniprotkb": "Calpain-13; 3.4.22.-; CANP 13; Calcium-activated neutral proteinase 13", "protein_names_refseq": "calcium-activated neutral proteinase 13; calpain-13", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:362701); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Probable non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK10-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK71-1", "uniprot_id": [ { "id": "ARL11_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK71", "type": "external" } ], "mass": 19156.0, "length": 173, "protein_name": "ADP-ribosylation factor-like protein 11", "gene_name": "Arl11", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 11", "refseq_ac": [ { "id": "NP_001013451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013451", "type": "external" } ], "gene_names_uniprotkb": "Arl11", "gene_names_refseq": "Arl11", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 11", "protein_names_refseq": "ADP-ribosylation factor like GTPase 11; ADP-ribosylation factor-like 11; ADP-ribosylation factor-like protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:364396)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May play a role in apoptosis. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BQE6-1", "uniprot_id": [ { "id": "DHC24_RAT", "url": "https://www.uniprot.org/uniprot/Q5BQE6", "type": "external" } ], "mass": 60047.0, "length": 516, "protein_name": "Delta(24)-sterol reductase", "gene_name": "Dhcr24", "organism": "Rat", "refseq_name": "delta(24)-sterol reductase precursor", "refseq_ac": [ { "id": "NP_001073617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073617", "type": "external" } ], "gene_names_uniprotkb": "Dhcr24", "gene_names_refseq": "Dhcr24", "protein_names_uniprotkb": "Delta(24)-sterol reductase; 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase", "protein_names_refseq": "3-beta-hydroxysterol delta-24-reductase; delta(24)-sterol reductase precursor; delta(24)-sterol reductase; seladin-1", "tax_id": 10116, "disease": "desmosterolosis (Disease Ontology:DOID:0070654); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (rno:298298); (R-RNO-6807047); (R-RNO-6807062); (R-RNO-9969901)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19520779;24842139;24916565;34338991", "class_list": "", "function": "Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis., [UniProtKB, UniProtKB]; Data suggest that expression of Dhcr24 is up-/down-regulated in rat striatal precursor cell line during oxidative stress depending on co-expression level of wild-type/mutant human huntingtin., [RefSeq, PubMed]; Expression of the seladin-1 gene (DHCR24) on days 9, 10, and 11 may contribute to the development of hair follicle stem cells., [RefSeq, PubMed]; Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons., [RefSeq, PubMed]; Seladin-1 expression and intracellular localization are correlated with both the intensity and nature of ACTH-induced steroidogenesis and resultant oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.72", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.72", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0071949 FAD binding;GO:0042605 peptide antigen binding;GO:0016491 oxidoreductase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0061024 membrane organization;GO:0006695 cholesterol biosynthetic process;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5BQE6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVH0-1", "uniprot_id": [ { "id": "C1QT5_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVH0", "type": "external" } ], "mass": 25334.0, "length": 243, "protein_name": "Complement C1q tumor necrosis factor-related protein 5", "gene_name": "C1qtnf5", "organism": "Rat", "refseq_name": "complement C1q tumor necrosis factor-related protein 5 precursor", "refseq_ac": [ { "id": "NP_001012123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012123", "type": "external" } ], "gene_names_uniprotkb": "C1qtnf5; Ctrp5", "gene_names_refseq": "Adie; C1qtnf5", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 5", "protein_names_refseq": "C1q and tumor necrosis factor related protein 5; adiponectin e; complement C1q tumor necrosis factor-related protein 5 precursor; complement C1q tumor necrosis factor-related protein 5", "tax_id": 10116, "disease": "late-onset retinal degeneration (Disease Ontology:DOID:0060869)", "pathway": " (rno:315598)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19651784;25195818", "class_list": "", "function": "CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation., [RefSeq, PubMed]; These results highlight C1QTNF5 as a putative biomarker for mitochondrial dysfunction and a potent activator of AMPK., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane", "go_biological_process": "GO:0009306 protein secretion;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVK6-1", "uniprot_id": [ { "id": "C2D1B_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVK6", "type": "external" } ], "mass": 93534.0, "length": 850, "protein_name": "Coiled-coil and C2 domain-containing protein 1B", "gene_name": "Cc2d1b", "organism": "Rat", "refseq_name": "coiled-coil and C2 domain-containing protein 1B", "refseq_ac": [ { "id": "NP_001257913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257913", "type": "external" } ], "gene_names_uniprotkb": "Cc2d1b", "gene_names_refseq": "Cc2d1b; RGD1306630", "protein_names_uniprotkb": "Coiled-coil and C2 domain-containing protein 1B; FRE under dual repression-binding protein 2; Five prime repressor element under dual repression-binding protein 2; Freud-2", "protein_names_refseq": "FRE under dual repression-binding protein 2; coiled-coil and C2 domain-containing protein 1B; five prime repressor element under dual repression-binding protein 2; freud-2", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:313478); (R-RNO-9668328)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20966424;27150226", "class_list": "", "function": "Freud-1 and Freud-2 levels were different in rats selectively bred for 85 generations for either high level of fear-induced aggression or its absence. Freud-1 protein level was decreased in the hippocampus, whereas Freud-2 protein level was increased in the frontal cortex of highly aggressive rats. There no differences in 5-HT1A receptor gene expression were found in the brains of highly aggressive and nonaggressive rats., [RefSeq, PubMed]; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5FVK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVL3-1", "uniprot_id": [ { "id": "DIK1B_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVL3", "type": "external" } ], "mass": 48838.0, "length": 431, "protein_name": "Divergent protein kinase domain 1B", "gene_name": "Dipk1b", "organism": "Rat", "refseq_name": "divergent protein kinase domain 1B", "refseq_ac": [ { "id": "NP_001014200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014200", "type": "external" } ], "gene_names_uniprotkb": "Dipk1b; Fam69b", "gene_names_refseq": "Dipk1b; Fam69b; PIP49; RGD1308600", "protein_names_uniprotkb": "Divergent protein kinase domain 1B; PIP49; Pancreatitis-induced protein 49; Protein FAM69B", "protein_names_refseq": "divergent protein kinase domain 1B; family with sequence similarity 69, member B; pancreatitis-induced protein 49; protein FAM69B", "tax_id": 10116, "disease": "", "pathway": " (rno:362090)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWS4-1", "uniprot_id": [ { "id": "CAHM5_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWS4", "type": "external" } ], "mass": 35363.0, "length": 309, "protein_name": "Calcium homeostasis modulator protein 5", "gene_name": "Calhm5", "organism": "Rat", "refseq_name": "calcium homeostasis modulator protein 5", "refseq_ac": [ { "id": "NP_001020148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020148", "type": "external" } ], "gene_names_uniprotkb": "Calhm5; Fam26e", "gene_names_refseq": "Calhm5; Fam26e; RGD1310405", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 5; Protein FAM26E", "protein_names_refseq": "calcium homeostasis modulator protein 5; family with sequence similarity 26, member E; protein FAM26E", "tax_id": 10116, "disease": "", "pathway": " (rno:294431)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWS4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWU3-1", "uniprot_id": [ { "id": "ATG9A_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWU3", "type": "external" } ], "mass": 94488.0, "length": 839, "protein_name": "Autophagy-related protein 9A", "gene_name": "Atg9a", "organism": "Rat", "refseq_name": "autophagy-related protein 9A", "refseq_ac": [ { "id": "NP_001014240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014240", "type": "external" } ], "gene_names_uniprotkb": "Atg9a; Apg9l1", "gene_names_refseq": "Atg9a; RGD1310450", "protein_names_uniprotkb": "Autophagy-related protein 9A; APG9-like 1", "protein_names_refseq": "APG9-like 1; ATG9 autophagy related 9 homolog A; autophagy-related protein 9A", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:363254); (R-RNO-1632852); (R-RNO-5205685)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0031667 response to nutrient levels;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FWU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZW3-1", "uniprot_id": [ { "id": "ASPH2_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZW3", "type": "external" } ], "mass": 38727.0, "length": 343, "protein_name": "Aspartate beta-hydroxylase domain-containing protein 2", "gene_name": "Asphd2", "organism": "Rat", "refseq_name": "aspartate beta-hydroxylase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001009716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009716", "type": "external" } ], "gene_names_uniprotkb": "Asphd2", "gene_names_refseq": "Asphd2; RGD1306020", "protein_names_uniprotkb": "Aspartate beta-hydroxylase domain-containing protein 2; 1.14.11.-", "protein_names_refseq": "3110001L23Rik; aspartate beta-hydroxylase domain-containing protein 2; calsequestrin-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:364948)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as 2-oxoglutarate-dependent dioxygenase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051213 dioxygenase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0K3-1", "uniprot_id": [ { "id": "CLYBL_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0K3", "type": "external" } ], "mass": 37321.0, "length": 338, "protein_name": "Citramalyl-CoA lyase, mitochondrial", "gene_name": "Clybl", "organism": "Rat", "refseq_name": "citramalyl-CoA lyase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001094155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094155", "type": "external" } ], "gene_names_uniprotkb": "Clybl", "gene_names_refseq": "Clybl", "protein_names_uniprotkb": "Citramalyl-CoA lyase, mitochondrial; (3S)-malyl-CoA thioesterase; 2.3.3.-; 2.3.3.9; 3.1.2.30; 4.1.3.25; Beta-methylmalate synthase; Citrate lyase beta-like; Citrate lyase subunit beta-like protein, mitochondrial; Malate synthase", "protein_names_refseq": "(3S)-malyl-CoA thioesterase; beta-methylmalate synthase; citramalyl-CoA lyase, mitochondrial precursor; citramalyl-CoA lyase, mitochondrial; citrate lyase beta like; citrate lyase subunit beta-like protein, mitochondrial; malate synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:306198)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites. Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.-", "type": "external" }, { "id": "2.3.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.9", "type": "external" }, { "id": "4.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.25", "type": "external" }, { "id": "3.1.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.30", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016289 acyl-CoA hydrolase activity;GO:0004474 malate synthase activity;GO:0047777 (S)-citramalyl-CoA lyase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0070207 protein homotrimerization;GO:0106064 regulation of cobalamin metabolic process;GO:0106121 positive regulation of cobalamin metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0K3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE0-1", "uniprot_id": [ { "id": "AN32E_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE0", "type": "external" } ], "mass": 29418.0, "length": 258, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "gene_name": "Anp32e", "organism": "Rat", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member E", "refseq_ac": [ { "id": "NP_001013218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013218", "type": "external" } ], "gene_names_uniprotkb": "Anp32e", "gene_names_refseq": "Anp32e", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member E", "protein_names_refseq": "acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; acidic leucine-rich nuclear phosphoprotein 32 family member E", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:361999)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15895553", "class_list": "", "function": "Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019212 phosphatase inhibitor activity;GO:0042393 histone binding;GO:0044183 protein folding chaperone;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1Z7-1", "uniprot_id": [ { "id": "CENPR_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1Z7", "type": "external" } ], "mass": 19917.0, "length": 176, "protein_name": "Centromere protein R", "gene_name": "Itgb3bp", "organism": "Rat", "refseq_name": "centromere protein R", "refseq_ac": [ { "id": "NP_001013231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013231", "type": "external" } ], "gene_names_uniprotkb": "Itgb3bp; Cenpr; Nrif3", "gene_names_refseq": "Itgb3bp", "protein_names_uniprotkb": "Centromere protein R; CENP-R; Nuclear receptor-interacting factor 3", "protein_names_refseq": "CENP-R; beta3-endonexin; centromere protein R; integrin beta 3 binding protein (beta3-endonexin); nuclear receptor-interacting factor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362548); (R-RNO-141430); (R-RNO-141444); (R-RNO-205043); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription coregulator that can have both coactivator and corepressor functions., [UniProtKB, UniProtKB, UniProtKB]; Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0005634 nucleus", "go_biological_process": "GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1Z7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXM5-1", "uniprot_id": [ { "id": "CEPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXM5", "type": "external" } ], "mass": 46498.0, "length": 416, "protein_name": "Choline/ethanolaminephosphotransferase 1", "gene_name": "Cept1", "organism": "Rat", "refseq_name": "choline/ethanolaminephosphotransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_001007700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007700", "type": "external" } ], "gene_names_uniprotkb": "Cept1", "gene_names_refseq": "Cept1", "protein_names_uniprotkb": "Choline/ethanolaminephosphotransferase 1; 1-alkenyl-2-acylglycerol choline phosphotransferase; 2.7.8.1; 2.7.8.22; 2.7.8.2", "protein_names_refseq": "1-alkenyl-2-acylglycerol choline phosphotransferase; choline/ethanolaminephosphotransferase 1 isoform 1", "tax_id": 10116, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:310773); (R-RNO-1483191); (R-RNO-1483213)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups;GO:0004307 ethanolaminephosphotransferase activity;GO:0047359 1-alkenyl-2-acylglycerol choline phosphotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006656 phosphatidylcholine biosynthetic process;GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXM5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPB4-1", "uniprot_id": [ { "id": "CD276_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPB4", "type": "external" } ], "mass": 34075.0, "length": 316, "protein_name": "CD276 antigen", "gene_name": "Cd276", "organism": "Rat", "refseq_name": "CD276 antigen precursor", "refseq_ac": [ { "id": "NP_877976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877976", "type": "external" } ], "gene_names_uniprotkb": "Cd276; B7h3", "gene_names_refseq": "B7RP-2; B7h3; Cd276", "protein_names_uniprotkb": "CD276 antigen; B7 homolog 3; B7-H3; Costimulatory molecule", "protein_names_refseq": "B7 homolog 3; B7-H3; CD276 antigen precursor; CD276 antigen; costimulatory molecule", "tax_id": 10116, "disease": "", "pathway": " (rno:315716)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12925852", "class_list": "", "function": "Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. May play a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0032689 negative regulation of type II interferon production;GO:0042110 T cell activation;GO:0042130 negative regulation of T cell proliferation;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TPB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HA6-1", "uniprot_id": [ { "id": "ARL8B_RAT", "url": "https://www.uniprot.org/uniprot/Q66HA6", "type": "external" } ], "mass": 21539.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 8B", "gene_name": "Arl8b", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 8B", "refseq_ac": [ { "id": "NP_001019503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019503", "type": "external" } ], "gene_names_uniprotkb": "Arl8b", "gene_names_refseq": "Arl8b", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8B; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor like GTPase 8B; ADP-ribosylation factor-like 8B; ADP-ribosylation factor-like protein 8B", "tax_id": 10116, "disease": "", "pathway": " (rno:500282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (By similarity). Recruits RUFY1 onto early endosomes regulating endosomes to trans-Golgi network proteins retrieval (By similarity). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0048487 beta-tubulin binding;GO:0019003 GDP binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse;GO:0051233 spindle midzone", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HA6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M888-1", "uniprot_id": [ { "id": "CG025_RAT", "url": "https://www.uniprot.org/uniprot/Q5M888", "type": "external" } ], "mass": 46464.0, "length": 421, "protein_name": "UPF0415 protein C7orf25 homolog", "gene_name": "C17h7orf25", "organism": "Rat", "refseq_name": "UPF0415 protein C7orf25 homolog", "refseq_ac": [ { "id": "NP_001014032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014032", "type": "external" } ], "gene_names_uniprotkb": "C17h7orf25; RGD1308147", "gene_names_refseq": "C17h7orf25; RGD1308147", "protein_names_uniprotkb": "UPF0415 protein C7orf25 homolog", "protein_names_refseq": "UPF0415 protein C7orf25 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M888-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUW3-1", "uniprot_id": [ { "id": "CFAI_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUW3", "type": "external" } ], "mass": 67298.0, "length": 604, "protein_name": "Complement factor I", "gene_name": "Cfi", "organism": "Rat", "refseq_name": "complement factor I precursor", "refseq_ac": [ { "id": "NP_077071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077071", "type": "external" } ], "gene_names_uniprotkb": "Cfi; If", "gene_names_refseq": "Cfi; FI", "protein_names_uniprotkb": "Complement factor I; 3.4.21.45; C3B/C4B inactivator", "protein_names_refseq": "C3B/C4B inactivator; complement factor I precursor", "tax_id": 10116, "disease": "complement factor I deficiency (Disease Ontology:DOID:0050419); atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); age related macular degeneration 13 (Disease Ontology:DOID:0110025); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); nephrotic syndrome (Disease Ontology:DOID:1184); glomerulonephritis (Disease Ontology:DOID:2921); macular degeneration (Disease Ontology:DOID:4448); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:79126); (R-RNO-977606)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10583609", "class_list": "", "function": "Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBC4", "ec_number_list": [ { "id": "3.4.21.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.45", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:1905370 serine-type endopeptidase complex;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0045087 innate immune response;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WUW3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI53-1", "uniprot_id": [ { "id": "CACL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI53", "type": "external" } ], "mass": 38826.0, "length": 347, "protein_name": "CDK2-associated and cullin domain-containing protein 1", "gene_name": "Cacul1", "organism": "Rat", "refseq_name": "CDK2-associated and cullin domain-containing protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001014270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014270", "type": "external" } ], "gene_names_uniprotkb": "Cacul1", "gene_names_refseq": "Cacul1; RGD1308127", "protein_names_uniprotkb": "CDK2-associated and cullin domain-containing protein 1", "protein_names_refseq": "CDK2-associated and cullin domain-containing protein 1 isoform 2; CDK2-associated and cullin domain-containing protein 1; uncharacterized protein C10orf46 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:365493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045860 positive regulation of protein kinase activity;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTY0-1", "uniprot_id": [ { "id": "AQP6_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTY0", "type": "external" } ], "mass": 28860.0, "length": 276, "protein_name": "Aquaporin-6", "gene_name": "Aqp6", "organism": "Rat", "refseq_name": "aquaporin-6", "refseq_ac": [ { "id": "NP_071517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071517", "type": "external" } ], "gene_names_uniprotkb": "Aqp6", "gene_names_refseq": "Aqp6", "protein_names_uniprotkb": "Aquaporin-6; AQP-6", "protein_names_refseq": "AQP-6; aquaporin 6, kidney specific; aquaporin-6", "tax_id": 10116, "disease": "", "pathway": " (rno:29170)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10318966;10647010;12034750;12177001;21851171;23183829;23485707;26526333;34211055", "class_list": "", "function": "A region within the third extracellular loop of rat Aquaporin 6 precludes trafficking to plasma membrane in a heterologous cell line. Publication Status: Online-Only, [RefSeq, PubMed]; AQP6 is involved in osmoregulation to maintain both the acid-base and osmotic balance of parotid secretory granules., [RefSeq, PubMed]; AQP6 labeling of the outer plexiform layer was decreased in retinal slices from diabetic rats in comparison to slices from control rats., [RefSeq, PubMed]; Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:10647010, PubMed:12034750, PubMed:12177001). Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability (PubMed:10647010, PubMed:12034750, PubMed:23485707). It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro (PubMed:23485707)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Confirmed AQP6 expression in retinal ganglion cells and Muller cells in vitro, [RefSeq, PubMed]; The primary role of AQP6 may be in cellular regulation, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005253 monoatomic anion channel activity;GO:0015112 nitrate transmembrane transporter activity;GO:0015250 water channel activity;GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity", "go_cellular_component": "GO:0030658 transport vesicle membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042476 odontogenesis;GO:0003097 renal water transport;GO:0015706 nitrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WTY0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CF82-1", "uniprot_id": [ { "id": "ABCA5_RAT", "url": "https://www.uniprot.org/uniprot/Q8CF82", "type": "external" } ], "mass": 185811.0, "length": 1642, "protein_name": "Cholesterol transporter ABCA5", "gene_name": "Abca5", "organism": "Rat", "refseq_name": "cholesterol transporter ABCA5", "refseq_ac": [ { "id": "NP_775429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775429", "type": "external" } ], "gene_names_uniprotkb": "Abca5", "gene_names_refseq": "Abca5", "protein_names_uniprotkb": "Cholesterol transporter ABCA5; 7.6.2.-; ATP-binding cassette sub-family A member 5", "protein_names_refseq": "ATP-binding cassette sub-family A member 5; ATP-binding cassette, sub-family A (ABC1), member 5; ATP-binding cassette, subfamily A (ABC1), member 5; cholesterol transporter ABCA5", "tax_id": 10116, "disease": "", "pathway": " (rno:286970); (R-RNO-1369062)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12504089;16162093", "class_list": "", "function": "Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes., [UniProtKB, UniProtKB]; Expression of rAbca5 mRNA in Leydig cells, intracellular localization of rAbca5-EGFP/rAbca5-V5 and involvement of rAbca5-related proteins in lipid transport suggest that rAbca5 may participate in intracellular sterol/steroid trafficking., [RefSeq, PubMed]; Molecular cloning of Abca5., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80Z07", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0010745 negative regulation of macrophage derived foam cell differentiation;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CF82-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B959-1", "uniprot_id": [ { "id": "APLD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6B959", "type": "external" } ], "mass": 26829.0, "length": 246, "protein_name": "Apolipoprotein L domain-containing protein 1", "gene_name": "Apold1", "organism": "Rat", "refseq_name": "apolipoprotein L domain-containing protein 1", "refseq_ac": [ { "id": "NP_001003403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003403", "type": "external" } ], "gene_names_uniprotkb": "Apold1; Verge", "gene_names_refseq": "Apold1; Verge", "protein_names_uniprotkb": "Apolipoprotein L domain-containing protein 1; Vascular early response gene protein", "protein_names_refseq": "apolipoprotein L domain-containing protein 1; vascular early response gene protein", "tax_id": 10116, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:444983)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15102925", "class_list": "", "function": "Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton. It also plays a role in the modulation of secretory autophagy (By similarity). May affect blood-brain barrier permeability., [UniProtKB, PubMed, UniProtKB]; We describe a novel immediate early gene that is expressed selectively in vascular endothelial cells. These studies suggest that Verge functions as a dynamic regulator of endothelial cell signaling and vascular function. [Verge], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030133 transport vesicle", "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0001525 angiogenesis;GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6B959-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ50-1", "uniprot_id": [ { "id": "ATG3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ50", "type": "external" } ], "mass": 35822.0, "length": 314, "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "Atg3", "organism": "Rat", "refseq_name": "ubiquitin-like-conjugating enzyme ATG3", "refseq_ac": [ { "id": "NP_599221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599221", "type": "external" } ], "gene_names_uniprotkb": "Atg3; Apg3l", "gene_names_refseq": "Apg3l; Atg3; PIG-1; Pig1", "protein_names_uniprotkb": "Ubiquitin-like-conjugating enzyme ATG3; 2.3.2.-; APG3-like; Autophagy-related protein 3; Preconditioning-inducible gene 1 protein", "protein_names_refseq": "APG3 autophagy 3-like; ATG3 autophagy related 3 homolog; autophagy-related protein 3; preconditioning-inducible gene 1 protein; ubiquitin-like-conjugating enzyme ATG3", "tax_id": 10116, "disease": "", "pathway": " (rno:171415); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26061804;29311554", "class_list": "", "function": "A thiol-dependent process is being reported that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7. Publication Status: Online-Only, [RefSeq, PubMed]; ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells, [RefSeq, PubMed]; E2 conjugating enzyme that catalyzes the covalent conjugation of the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to the amino group of phosphatidylethanolamine (PE)-containing lipids in the membrane resulting in membrane-bound ATG8-like proteins which is one of the key steps in the development of autophagic isolation membranes during autophagosome formation. Cycles back and forth between binding to ATG7 for loading with the ATG8-like proteins and binding to E3 enzyme, composed of ATG12, ATG5 and ATG16L1 to promote ATG8-like proteins lipidation (By similarity). Also plays a role as a membrane curvature sensor that facilitates LC3/GABARAP lipidation by sensing local membrane stress associated with lipid-packing defects as occurs with high molar proportions of conical lipids or strident membrane curvature (By similarity). Interacts with negatively-charged membranes promoting membrane tethering and enhancing LC3/GABARAP lipidation (By similarity). Also acts as an autocatalytic E2-like enzyme by catalyzing the conjugation of ATG12 to itself in an ATG7-dependent manner, this complex thus formed, plays a role in mitochondrial homeostasis but not in autophagy. ATG12-ATG3 conjugation promotes late endosome to lysosome trafficking and basal autophagosome maturation via its interaction with PDCD6IP. ATG12-ATG3 conjugate is also formed upon viccina virus infection, leading to the disruption the cellular autophagy which is not necessary for vaccinia survival and proliferation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESH2", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019787 ubiquitin-like protein transferase activity;GO:0019776 Atg8-family ligase activity;GO:0019777 Atg12 transferase activity;GO:0141046 Atg8-family conjugating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000407 phagophore assembly site;GO:0034274 Atg12-Atg5-Atg16 complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0006914 autophagy;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AZ50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC40-1", "uniprot_id": [ { "id": "NCBP2_RAT", "url": "https://www.uniprot.org/uniprot/B1WC40", "type": "external" } ], "mass": 18017.0, "length": 156, "protein_name": "Nuclear cap-binding protein subunit 2", "gene_name": "Ncbp2", "organism": "Rat", "refseq_name": "nuclear cap-binding protein subunit 2", "refseq_ac": [ { "id": "NP_001102995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102995", "type": "external" } ], "gene_names_uniprotkb": "Ncbp2; Cbp20", "gene_names_refseq": "CBP20; Ncbp2; Pigz", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 2; 20 kDa nuclear cap-binding protein; CBP20; NCBP 20 kDa subunit", "protein_names_refseq": "20 kDa nuclear cap-binding protein; NCBP 20 kDa subunit; nuclear cap-binding protein subunit 2-like; nuclear cap-binding protein subunit 2; phosphatidylinositol glycan anchor biosynthesis, class Z", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (rno:689116); (R-RNO-111367); (R-RNO-112382); (R-RNO-113418); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-674695); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73856); (R-RNO-77588); (R-RNO-77595); (R-RNO-975956); (R-RNO-975957); (R-RNO-9770562); (R-RNO-9930044)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0017069 snRNA binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0046833 positive regulation of RNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1WC40-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2W4-1", "uniprot_id": [ { "id": "CENPN_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2W4", "type": "external" } ], "mass": 39459.0, "length": 340, "protein_name": "Centromere protein N", "gene_name": "Cenpn", "organism": "Rat", "refseq_name": "centromere protein N", "refseq_ac": [ { "id": "NP_001008367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008367", "type": "external" } ], "gene_names_uniprotkb": "Cenpn", "gene_names_refseq": "Cenpn; Da2-27; Da2-4; RGD1310953", "protein_names_uniprotkb": "Centromere protein N; CENP-N", "protein_names_refseq": "CENP-N; centromere protein N", "tax_id": 10116, "disease": "", "pathway": " (rno:361416); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0007059 chromosome segregation;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2W4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62745-1", "uniprot_id": [ { "id": "CD81_RAT", "url": "https://www.uniprot.org/uniprot/Q62745", "type": "external" } ], "mass": 25889.0, "length": 236, "protein_name": "CD81 antigen", "gene_name": "Cd81", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd81; Tapa1", "gene_names_refseq": "", "protein_names_uniprotkb": "CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "common variable immunodeficiency 6 (Disease Ontology:DOID:0081149)", "pathway": " (R-RNO-198933); (R-RNO-977606)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8757260", "class_list": "", "function": "Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation (By similarity). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction. In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (By similarity). Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels (By similarity). Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0015485 cholesterol binding;GO:0001618 virus receptor activity;GO:1990459 transferrin receptor binding;GO:0042289 MHC class II protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:1903911 positive regulation of receptor clustering;GO:0031623 receptor internalization;GO:0040008 regulation of growth;GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62745-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z5-1", "uniprot_id": [ { "id": "CHAC2_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z5", "type": "external" } ], "mass": 20167.0, "length": 178, "protein_name": "Putative glutathione-specific gamma-glutamylcyclotransferase 2", "gene_name": "Chac2", "organism": "Rat", "refseq_name": "putative glutathione-specific gamma-glutamylcyclotransferase 2", "refseq_ac": [ { "id": "NP_001020187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020187", "type": "external" } ], "gene_names_uniprotkb": "Chac2", "gene_names_refseq": "Chac2; RGD1309120", "protein_names_uniprotkb": "Putative glutathione-specific gamma-glutamylcyclotransferase 2; 4.3.2.7; Cation transport regulator-like protein 2; Gamma-GCG 2", "protein_names_refseq": "ChaC cation transport regulator 2; ChaC, cation transport regulator homolog 2; cation transport regulator-like protein 2; gamma-GCG 2; putative glutathione-specific gamma-glutamylcyclotransferase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360994); (R-RNO-174403)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity;GO:0003839 gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006751 glutathione catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641Z5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ05-1", "uniprot_id": [ { "id": "C1GLT_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ05", "type": "external" } ], "mass": 42311.0, "length": 363, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "gene_name": "C1galt1", "organism": "Rat", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 2", "refseq_ac": [ { "id": "NP_075239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075239", "type": "external" } ], "gene_names_uniprotkb": "C1galt1", "gene_names_refseq": "C1galt1", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; 2.4.1.122; C1GalT1; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1; Core 1 beta3-Gal-T1", "protein_names_refseq": "core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core 1 beta1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; core 1 beta3-Gal-T; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase (C1galt1); core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 13-galactosyltransferase (C1galt1); glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 2; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "tax_id": 10116, "disease": "autoimmune disease of blood (Disease Ontology:DOID:0060050)", "pathway": " (rno:65044); (R-RNO-913709)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11673471;11677243", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins (PubMed:11673471). Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.122", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001822 kidney development;GO:0006493 protein O-linked glycosylation;GO:0060576 intestinal epithelial cell development", "synthesized_glycan_count": 3300, "hit_score": 0.3, "record_id": "Q9JJ05-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU49-1", "uniprot_id": [ { "id": "CHSP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU49", "type": "external" } ], "mass": 15906.0, "length": 147, "protein_name": "Calcium-regulated heat stable protein 1", "gene_name": "Carhsp1", "organism": "Rat", "refseq_name": "calcium-regulated heat stable protein 1", "refseq_ac": [ { "id": "NP_690003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690003", "type": "external" } ], "gene_names_uniprotkb": "Carhsp1", "gene_names_refseq": "Carhsp1; Crhsp-24; Crhsp24", "protein_names_uniprotkb": "Calcium-regulated heat stable protein 1; CRHSP-24; Calcium-regulated heat-stable protein of 24 kDa", "protein_names_refseq": "calcium-regulated heat stable protein 1; calcium-regulated heat-stable protein (24kD); calcium-regulated heat-stable protein of 24 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:260416)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12801884;15910284;16396499;16641100;19477163;22673903;7515049;9712905", "class_list": "", "function": "Binds mRNA and regulates the stability of target mRNA., [UniProtKB]; Coordinate phosphorylation of four serines explains the multiple phosphorylated isoforms of CRHSP-24 present in acinar cells., [RefSeq, PubMed]; Data indicate that calcium-regulated heat-stable protein-24 is regulated by diverse and physiologically relevant signaling pathways in pancreatic acinar cells, [RefSeq, PubMed]; The purification and identification of CRHSP24 in rat liver extracts, and its role as a substrate for multiple enzymes are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0000177 cytoplasmic exosome (RNase complex);GO:0043186 P granule", "go_biological_process": "GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WU49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FW8-1", "uniprot_id": [ { "id": "BIN3_RAT", "url": "https://www.uniprot.org/uniprot/Q68FW8", "type": "external" } ], "mass": 29691.0, "length": 253, "protein_name": "Bridging integrator 3", "gene_name": "Bin3", "organism": "Rat", "refseq_name": "bridging integrator 3", "refseq_ac": [ { "id": "NP_001013204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013204", "type": "external" } ], "gene_names_uniprotkb": "Bin3", "gene_names_refseq": "Bin3", "protein_names_uniprotkb": "Bridging integrator 3", "protein_names_refseq": "bridging integrator 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361065)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Involved in cytokinesis and septation where it has a role in the localization of F-actin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006897 endocytosis;GO:0051301 cell division;GO:0048741 skeletal muscle fiber development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H62-1", "uniprot_id": [ { "id": "CYLD_RAT", "url": "https://www.uniprot.org/uniprot/Q66H62", "type": "external" } ], "mass": 106713.0, "length": 953, "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "Cyld", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase CYLD", "refseq_ac": [ { "id": "NP_001017380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017380", "type": "external" } ], "gene_names_uniprotkb": "Cyld; Cyld1", "gene_names_refseq": "Cyld; LRRGT00003; Rp1h; Rp1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase CYLD; 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD", "protein_names_refseq": "40S ribosomal protein S3a-like; cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD-like; probable ubiquitin carboxyl-terminal hydrolase CYLD; retinitis pigmentosa 1 homolog; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD", "tax_id": 10116, "disease": "Brooke-Spiegler syndrome (Disease Ontology:DOID:0050693); multiple familial trichoepithelioma 1 (Disease Ontology:DOID:0061187)", "pathway": " (rno:312937); (R-RNO-168638); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5689880); (R-RNO-936440)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "22673903;28751569;34216581;35435104", "class_list": "", "function": "Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-kappaB signaling., [RefSeq, PubMed]; CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling., [RefSeq, PubMed]; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins. Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (By similarity). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; LncRNA growth arrest specific transcript 5 inhibits the growth of pituitary neuroendocrine tumors via miR-27a-5p/cylindromatosis axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0070064 proline-rich region binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66H62-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M883-1", "uniprot_id": [ { "id": "CLIC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M883", "type": "external" } ], "mass": 28161.0, "length": 245, "protein_name": "Chloride intracellular channel protein 2", "gene_name": "Clic2", "organism": "Rat", "refseq_name": "chloride intracellular channel protein 2", "refseq_ac": [ { "id": "NP_001009651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009651", "type": "external" } ], "gene_names_uniprotkb": "Clic2", "gene_names_refseq": "Clic2", "protein_names_uniprotkb": "Chloride intracellular channel protein 2; 1.11.1.-; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC2; Glutaredoxin-like peroxidase CLIC2", "protein_names_refseq": "chloride intracellular channel 2; chloride intracellular channel protein 2; glutaredoxin-like oxidoreductase CLIC2; glutaredoxin-like peroxidase CLIC2", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:294141); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "34229297", "class_list": "", "function": "Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (By similarity). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004602 glutathione peroxidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M883-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP48-1", "uniprot_id": [ { "id": "APMAP_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP48", "type": "external" } ], "mass": 42062.0, "length": 376, "protein_name": "Adipocyte plasma membrane-associated protein", "gene_name": "Apmap", "organism": "Rat", "refseq_name": "adipocyte plasma membrane-associated protein isoform 3", "refseq_ac": [ { "id": "NP_001029175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029175", "type": "external" } ], "gene_names_uniprotkb": "Apmap; Ab2-305", "gene_names_refseq": "Ab2-305; Apmap; RGD1308874", "protein_names_uniprotkb": "Adipocyte plasma membrane-associated protein", "protein_names_refseq": "adipocyte plasma membrane-associated protein isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:366227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KR93", "ec_number_list": [], "go_molecular_function": "GO:0004064 arylesterase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TP48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R010-1", "uniprot_id": [ { "id": "CIB1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R010", "type": "external" } ], "mass": 21800.0, "length": 191, "protein_name": "Calcium and integrin-binding protein 1", "gene_name": "Cib1", "organism": "Rat", "refseq_name": "calcium and integrin-binding protein 1", "refseq_ac": [ { "id": "NP_112407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112407", "type": "external" } ], "gene_names_uniprotkb": "Cib1; Cib; Kip; Prkdcip", "gene_names_refseq": "Cib1; Cib; Sip2-28", "protein_names_uniprotkb": "Calcium and integrin-binding protein 1; CIB; Calmyrin; DNA-PKcs-interacting protein; KIP; Kinase-interacting protein", "protein_names_refseq": "DNA-PKcs-interacting protein; KIP; calcium and integrin-binding protein 1; calcium- and integrin-binding protein; calmyrin; kinase-interacting protein", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); epidermodysplasia verruciformis (Disease Ontology:DOID:13777)", "pathway": " (rno:81823)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10523297;18627437;20639889;21215777", "class_list": "", "function": "CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain., [RefSeq, PubMed]; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKA8", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R010-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1A0-1", "uniprot_id": [ { "id": "CCNH_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1A0", "type": "external" } ], "mass": 37610.0, "length": 323, "protein_name": "Cyclin-H", "gene_name": "Ccnh", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccnh", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-H", "protein_names_refseq": "", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:84389); (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-69200); (R-RNO-69202); (R-RNO-69231); (R-RNO-69273); (R-RNO-69656); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-8939236)", "pathway_count": 25, "publication_count": 3, "publication_id_list": "10501206;11252168;22673903", "class_list": "", "function": "Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalyzing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK (By similarity). CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression (By similarity). CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts (By similarity). Involved in cell cycle control and in RNA transcription by RNA polymerase II (By similarity). Its expression and activity are constant throughout the cell cycle., [UniProtKB, UniProtKB]; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JE5", "ec_number_list": [], "go_molecular_function": "GO:0016301 kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0070985 transcription factor TFIIK complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1A0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63151-1", "uniprot_id": [ { "id": "ACSL3_RAT", "url": "https://www.uniprot.org/uniprot/Q63151", "type": "external" } ], "mass": 80458.0, "length": 720, "protein_name": "Fatty acid CoA ligase Acsl3", "gene_name": "Acsl3", "organism": "Rat", "refseq_name": "fatty acid CoA ligase Acsl3", "refseq_ac": [ { "id": "NP_476448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476448", "type": "external" } ], "gene_names_uniprotkb": "Acsl3; Acs3; Facl3", "gene_names_refseq": "Acs3; Acsl3; Facl3; LACS 3", "protein_names_uniprotkb": "Fatty acid CoA ligase Acsl3; 6.2.1.15; 6.2.1.2; 6.2.1.3; Arachidonate--CoA ligase Acsl3; Brain acyl-CoA synthetase II; LACS 3; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; Medium-chain acyl-CoA ligase Acsl3", "protein_names_refseq": "arachidonate--CoA ligase Acsl3; arachidonate--CoA ligase; brain acyl-CoA synthetase II; fatty acid CoA ligase Acsl3; fatty acid Coenzyme A ligase, long chain 3; long-chain acyl-CoA synthetase 3; long-chain-fatty-acid--CoA ligase 3; medium-chain acyl-CoA ligase Acsl3", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:114024); (R-RNO-434313); (R-RNO-75876)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15683247;19737935;28209804;8663269;9276691", "class_list": "", "function": "Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:15683247, PubMed:19737935, PubMed:28209804). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis (PubMed:19737935). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (PubMed:8663269, PubMed:9276691). Both isoforms exhibit the same level of activity (PubMed:9276691)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0007584 response to nutrient;GO:0006633 fatty acid biosynthetic process;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042998 positive regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63151-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHU5-1", "uniprot_id": [ { "id": "ARFP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHU5", "type": "external" } ], "mass": 40779.0, "length": 366, "protein_name": "Arfaptin-1", "gene_name": "Arfip1", "organism": "Rat", "refseq_name": "arfaptin-1 isoform 2", "refseq_ac": [ { "id": "NP_068531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068531", "type": "external" } ], "gene_names_uniprotkb": "Arfip1", "gene_names_refseq": "Arfip1", "protein_names_uniprotkb": "Arfaptin-1; ADP-ribosylation factor-interacting protein 1", "protein_names_refseq": "ADP-ribosylation factor interacting protein 1; arfaptin-1 isoform 2; arfaptin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:60382)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;22981988", "class_list": "", "function": "Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells., [UniProtKB, UniProtKB]; The protein kinase D (PKD) phosphorylates Arfaptin-1 at serine 132, which disrupts the ability of Arfaptin-1 to inhibit the activity of ADP ribosylation factor, an important component of the vesicle scission machinery., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:1905280 negative regulation of retrograde transport, endosome to Golgi;GO:0006886 intracellular protein transport;GO:0050708 regulation of protein secretion;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ60-1", "uniprot_id": [ { "id": "CAC1H_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQ60", "type": "external" } ], "mass": 261113.0, "length": 2359, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha-1H", "gene_name": "Cacna1h", "organism": "Rat", "refseq_name": "voltage-dependent T-type calcium channel subunit alpha-1H", "refseq_ac": [ { "id": "NP_722521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722521", "type": "external" } ], "gene_names_uniprotkb": "Cacna1h", "gene_names_refseq": "Cacna1h", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-gated calcium channel subunit alpha Cav3.2", "protein_names_refseq": "calcium channel, voltage-dependent, T type, alpha 1H subunit; voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel subunit alpha Cav3.2", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); childhood absence epilepsy (Disease Ontology:DOID:1825); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (rno:114862)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11073957;12530678;14729682;15616581;29684385;31744861;32971090;37391087;38325845", "class_list": "", "function": "Activation of native 5-HT7 receptors stimulates cAMP formation, which in turn provokes calcium influx through T-type calcium channels. Both activation of AC/PKA pathway and calcium influx are involved in 5-HT-induced aldosterone secretion., [RefSeq, PubMed]; Ca(v)3.2 has a role in calcium influx during physiological activation and mutations may be causative in the propensity for seizures in patients with childhood absence epilepsy, [RefSeq, PubMed]; Cav3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain., [RefSeq, PubMed]; Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models., [RefSeq, PubMed]; Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission., [RefSeq, PubMed]; Results provide direct evidence linking CaV3.2 T-type channels to pain perception and suggest that CaV3.2 may offer a specific molecular target for the treatment of pain., [RefSeq, PubMed]; Study shows that the membrane expression and the function of Cav3.2 T-type calcium channels are increased in the intact L4 dorsal root ganglion neurons in neuropathic pain rats with peripheral nerve injury like spinal nerve ligation., [RefSeq, PubMed]; The present work shows that the exacerbated expression of Cdk5 in a preclinical model of neuropathic pain increases the functional expression of CaV3.2 channels, [RefSeq, PubMed]; Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 3, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0097110 scaffold protein binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0005245 voltage-gated calcium channel activity;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQ60-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G0-1", "uniprot_id": [ { "id": "DCTD_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G0", "type": "external" } ], "mass": 20059.0, "length": 178, "protein_name": "Deoxycytidylate deaminase", "gene_name": "Dctd", "organism": "Rat", "refseq_name": "deoxycytidylate deaminase isoform 1", "refseq_ac": [ { "id": "NP_001013904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013904", "type": "external" } ], "gene_names_uniprotkb": "Dctd", "gene_names_refseq": "Dctd", "protein_names_uniprotkb": "Deoxycytidylate deaminase; 3.5.4.12; dCMP deaminase", "protein_names_refseq": "deoxycytidylate deaminase isoform 1; deoxycytidylate deaminase", "tax_id": 10116, "disease": "", "pathway": " (rno:290741); (R-RNO-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0070694 5-hydroxymethyl-dUMP N-hydrolase activity;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0043174 nucleoside salvage;GO:0009165 nucleotide biosynthetic process;GO:0006220 pyrimidine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M9G0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY2-1", "uniprot_id": [ { "id": "TEX56_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY2", "type": "external" } ], "mass": 25319.0, "length": 218, "protein_name": "Testis expressed protein 56", "gene_name": "Tex56p; Tex56", "organism": "Rat", "refseq_name": "testis expressed protein 56", "refseq_ac": [ { "id": "NP_001013907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013907", "type": "external" } ], "gene_names_uniprotkb": "Tex56p; Tex56; C17h6orf201; RGD1307537", "gene_names_refseq": "C17h6orf201; RGD1307537; Tex56p; Tex56", "protein_names_uniprotkb": "Testis expressed protein 56", "protein_names_refseq": "testis expressed protein 56; uncharacterized protein C6orf201 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:291077)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQ46", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7U6-1", "uniprot_id": [ { "id": "ARP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7U6", "type": "external" } ], "mass": 44734.0, "length": 394, "protein_name": "Actin-related protein 2", "gene_name": "Actr2", "organism": "Rat", "refseq_name": "actin-related protein 2", "refseq_ac": [ { "id": "NP_001009268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009268", "type": "external" } ], "gene_names_uniprotkb": "Actr2; Arp2", "gene_names_refseq": "Actr2", "protein_names_uniprotkb": "Actin-related protein 2; Actin-like protein 2", "protein_names_refseq": "ARP2 actin related protein 2 homolog; actin-like protein 2; actin-related protein 2", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:289820); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213); (R-RNO-6798695); (R-RNO-8856828)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding;GO:0008092 cytoskeletal protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0008306 associative learning;GO:0045471 response to ethanol;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7U6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62840-1", "uniprot_id": [ { "id": "AMBN_RAT", "url": "https://www.uniprot.org/uniprot/Q62840", "type": "external" } ], "mass": 45206.0, "length": 422, "protein_name": "Ameloblastin", "gene_name": "Ambn", "organism": "Rat", "refseq_name": "ameloblastin precursor", "refseq_ac": [ { "id": "NP_037032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037032", "type": "external" } ], "gene_names_uniprotkb": "Ambn", "gene_names_refseq": "Ambn", "protein_names_uniprotkb": "Ameloblastin; Amelin", "protein_names_refseq": "amelin; ameloblastin precursor", "tax_id": 10116, "disease": "amelogenesis imperfecta type 1F (Disease Ontology:DOID:0110065)", "pathway": " (rno:25376); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12803485;17184233;18281204;19648121;20854943;21149578;27193486;8626794;8797107", "class_list": "", "function": "AMBN promotes cell binding through the heparin binding sites and plays an important role in preventing odontogenic tumor development by suppressing cell proliferation and maintaining differentiation phenotype through Msx2, p21, and p27., [RefSeq, PubMed]; Ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1, [RefSeq, PubMed]; Exon 3a and 11 are potential alternative splicing sites, producing 4 types of ameloblastin mRNA, from which ameloblastin I and II could be translated, [RefSeq, PubMed]; Express[ed] during craniofacial bone development in rats, [RefSeq, PubMed]; Findings suggest a role for this protein in early bone formation and repair., [RefSeq, PubMed]; Fluoride could decrease ameloblast viability, induce ameloblast apoptosis via activating FasL/Fas signaling pathway, and reduce AMBN secretion., [RefSeq, PubMed]; Involved in the mineralization and structural organization of enamel., [UniProtKB, UniProtKB, UniProtKB]; Subpopulation of granules containing only AMBN could be responsible for augmenting its local concentration along secretory surfaces against which hydroxyapatite crystals actively elongate, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q540J9;Q63043", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0030345 structural constituent of tooth enamel", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion;GO:0042127 regulation of cell population proliferation;GO:0042475 odontogenesis of dentin-containing tooth;GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62840-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7T3-1", "uniprot_id": [ { "id": "BRMS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7T3", "type": "external" } ], "mass": 28306.0, "length": 246, "protein_name": "Breast cancer metastasis-suppressor 1 homolog", "gene_name": "Brms1", "organism": "Rat", "refseq_name": "breast cancer metastasis-suppressor 1 homolog isoform 1", "refseq_ac": [ { "id": "NP_001009605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009605", "type": "external" } ], "gene_names_uniprotkb": "Brms1", "gene_names_refseq": "Brms1", "protein_names_uniprotkb": "Breast cancer metastasis-suppressor 1 homolog", "protein_names_refseq": "breast cancer metastasis suppressor 1; breast cancer metastasis-suppressor 1 homolog isoform 1; breast cancer metastasis-suppressor 1 homolog", "tax_id": 10116, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008)", "pathway": " (rno:293668); (R-RNO-3214815)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070822 Sin3-type complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7T3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TXF1-1", "uniprot_id": [ { "id": "ARRD3_RAT", "url": "https://www.uniprot.org/uniprot/Q6TXF1", "type": "external" } ], "mass": 46301.0, "length": 414, "protein_name": "Arrestin domain-containing protein 3", "gene_name": "Arrdc3", "organism": "Rat", "refseq_name": "arrestin domain-containing protein 3", "refseq_ac": [ { "id": "NP_001007798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007798", "type": "external" } ], "gene_names_uniprotkb": "Arrdc3", "gene_names_refseq": "Arrdc3; LRRGT00048", "protein_names_uniprotkb": "Arrestin domain-containing protein 3; Liver regeneration-related protein LRRG00048", "protein_names_refseq": "arrestin domain-containing protein 3; liver regeneration-related protein LRRG00048", "tax_id": 10116, "disease": "", "pathway": " (rno:309945)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36154540", "class_list": "", "function": "ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway., [RefSeq, PubMed]; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0031699 beta-3 adrenergic receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0009612 response to mechanical stimulus;GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0043588 skin development;GO:0031651 negative regulation of heat generation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6TXF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0K5-1", "uniprot_id": [ { "id": "ABHDA_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0K5", "type": "external" } ], "mass": 33153.0, "length": 297, "protein_name": "Palmitoyl-protein thioesterase ABHD10, mitochondrial", "gene_name": "Abhd10", "organism": "Rat", "refseq_name": "palmitoyl-protein thioesterase ABHD10, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001116824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116824", "type": "external" } ], "gene_names_uniprotkb": "Abhd10", "gene_names_refseq": "Abhd10; RGD1308084", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase ABHD10, mitochondrial; 3.1.1.93; 3.1.2.22; Abhydrolase domain-containing protein 10; Acyl-protein thioesterase ABHD10; Alpha/beta hydrolase domain-containing protein 10; Mycophenolic acid acyl-glucuronide esterase, mitochondrial", "protein_names_refseq": "abhydrolase domain-containing protein 10, mitochondrial; acyl-protein thioesterase ABHD10; alpha/beta hydrolase domain-containing protein 10, mitochondrial; mycophenolic acid acyl-glucuronide esterase, mitochondrial; palmitoyl-protein thioesterase ABHD10, mitochondrial precursor; palmitoyl-protein thioesterase ABHD10, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:303953); (R-RNO-156588)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20966424", "class_list": "", "function": "Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0102390 mycophenolic acid acyl-glucuronide esterase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0002084 protein depalmitoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI64-1", "uniprot_id": [ { "id": "ABHD6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI64", "type": "external" } ], "mass": 38312.0, "length": 337, "protein_name": "Monoacylglycerol lipase ABHD6", "gene_name": "Abhd6", "organism": "Rat", "refseq_name": "monoacylglycerol lipase ABHD6", "refseq_ac": [ { "id": "NP_001007681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007681", "type": "external" } ], "gene_names_uniprotkb": "Abhd6", "gene_names_refseq": "Abhd6", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; 3.1.1.23; Abhydrolase domain-containing protein 6", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 6; monoacylglycerol lipase ABHD6", "tax_id": 10116, "disease": "", "pathway": " (rno:305795); (R-RNO-426048)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "34468198", "class_list": "", "function": "Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha/Beta-Hydrolase Domain 6 Knockout Rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:2001311 lysobisphosphatidic acid metabolic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0009395 phospholipid catabolic process;GO:0030336 negative regulation of cell migration;GO:0046464 acylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIA4-1", "uniprot_id": [ { "id": "CNO10_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIA4", "type": "external" } ], "mass": 81819.0, "length": 744, "protein_name": "CCR4-NOT transcription complex subunit 10", "gene_name": "Cnot10", "organism": "Rat", "refseq_name": "CCR4-NOT transcription complex subunit 10", "refseq_ac": [ { "id": "NP_001007004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007004", "type": "external" } ], "gene_names_uniprotkb": "Cnot10", "gene_names_refseq": "Cnot10", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 10", "protein_names_refseq": "CCR4-NOT transcription complex subunit 10", "tax_id": 10116, "disease": "", "pathway": " (rno:316034); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQL2-1", "uniprot_id": [ { "id": "CNOT9_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQL2", "type": "external" } ], "mass": 33601.0, "length": 299, "protein_name": "CCR4-NOT transcription complex subunit 9", "gene_name": "Cnot9", "organism": "Rat", "refseq_name": "CCR4-NOT transcription complex subunit 9", "refseq_ac": [ { "id": "NP_001009357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009357", "type": "external" } ], "gene_names_uniprotkb": "Cnot9; Rcd1; Rqcd1", "gene_names_refseq": "Cnot9; Rqcd1", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 9; Cell differentiation protein RQCD1 homolog; Rcd-1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 9; cell differentiation protein RCD1 homolog; cell differentiation protein RQCD1 homolog; rcd-1; rcd1 (required for cell differentiation) homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:301513); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12356739;18180299", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0019900 kinase binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0032991 protein-containing complex;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV87-1", "uniprot_id": [ { "id": "PTPRE_RAT", "url": "https://www.uniprot.org/uniprot/B2GV87", "type": "external" } ], "mass": 80734.0, "length": 699, "protein_name": "Receptor-type tyrosine-protein phosphatase epsilon", "gene_name": "Ptpre", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase epsilon precursor", "refseq_ac": [ { "id": "NP_446219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446219", "type": "external" } ], "gene_names_uniprotkb": "Ptpre; Ptpe", "gene_names_refseq": "PTPepsilon; Ptpre", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase epsilon; 3.1.3.48; Protein-tyrosine phosphatase epsilon; R-PTP-epsilon", "protein_names_refseq": "R-PTP-epsilon; protein tyrosine phosphatase epsilon-like 1; protein tyrosine phosphatase epsilon-like 2; protein tyrosine phosphatase, receptor type, epsilon; receptor-type tyrosine-protein phosphatase epsilon precursor; receptor-type tyrosine-protein phosphatase epsilon", "tax_id": 10116, "disease": "", "pathway": " (rno:114767)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15738637;16990553;20686073;38843836;8579581;9914474", "class_list": "", "function": "Antioxidants inhibited neointima formation and reduced PDGF receptor phosphorylation in the neointima and also increased PTP activity., [RefSeq, PubMed]; Data show that PTPepsilonM negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTPepsilonM may be involved in diabetes-accelerated atherosclerosis., [RefSeq, PubMed]; Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver., [UniProtKB]; Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63476;Q63477", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway;GO:0007165 signal transduction;GO:0033003 regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "B2GV87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1G0-1", "uniprot_id": [ { "id": "CLMP_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1G0", "type": "external" } ], "mass": 41148.0, "length": 372, "protein_name": "CXADR-like membrane protein", "gene_name": "Clmp", "organism": "Rat", "refseq_name": "CXADR-like membrane protein precursor", "refseq_ac": [ { "id": "NP_775177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775177", "type": "external" } ], "gene_names_uniprotkb": "Clmp; Acam; Asam", "gene_names_refseq": "ACAM; Asam; Clmp; Ol16", "protein_names_uniprotkb": "CXADR-like membrane protein; Adipocyte adhesion molecule; CAR-like membrane protein; Coxsackie- and adenovirus receptor-like membrane protein", "protein_names_refseq": "CAR-like membrane protein; CXADR-like membrane protein precursor; CXADR-like membrane protein; adipocyte adhesion molecule; adipocyte-specific adhesion molecule; coxsackie- and adenovirus receptor-like membrane protein; visceral adipose tissue-specific transmembrane protein OL-16", "tax_id": 10116, "disease": "short bowel syndrome (Disease Ontology:DOID:10605)", "pathway": " (rno:286939)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15563274;25400132;33259866", "class_list": "", "function": "Data suggest that expression of Clmp in ovary during ovulation can be up-regulated by chorionic gonadotrophin; human chorionic gonadotrophin, a fertility agent, was used in these studies. Up-regulation of Clmp in ovary may be important in cell adhesion events during ovulation and luteal formation such as maintaining the structure and communication of ovarian follicular and luteal cells., [RefSeq, PubMed]; Enhanced expression of coxsackievirus and adenovirus receptor in lipopolysaccharide-induced inflammatory macrophages is through TRIF-dependent innate immunity pathway., [RefSeq, PubMed]; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; We identified ACAM (adipocyte adhesion molecule), a novel homologue of the CTX (cortical thymocyte marker in Xenopus) gene family, which may be the critical adhesion molecule in adipocyte differentiation and development of obesity., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0045211 postsynaptic membrane;GO:0005881 cytoplasmic microtubule;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0060612 adipose tissue development;GO:0030041 actin filament polymerization;GO:0048565 digestive tract development;GO:0034333 adherens junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K1G0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTT2-1", "uniprot_id": [ { "id": "CLPB_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTT2", "type": "external" } ], "mass": 75702.0, "length": 677, "protein_name": "Mitochondrial disaggregase", "gene_name": "Clpb", "organism": "Rat", "refseq_name": "mitochondrial disaggregase", "refseq_ac": [ { "id": "NP_075236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075236", "type": "external" } ], "gene_names_uniprotkb": "Clpb; Skd3", "gene_names_refseq": "Clpb; Skd3", "protein_names_uniprotkb": "Mitochondrial disaggregase; 3.6.1.-; Suppressor of potassium transport defect 3", "protein_names_refseq": "ClpB caseinolytic peptidase B homolog; ClpB homolog, mitochondrial AAA ATPase chaperonin; caseinolytic mitochondrial matrix peptidase chaperone subunit B; caseinolytic peptidase B protein homolog; mitochondrial disaggregase; suppressor of K+ transport defect 3; suppressor of potassium transport defect 3", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); 3-methylglutaconic aciduria type 7a (Disease Ontology:DOID:0081133); 3-methylglutaconic aciduria type 7b (Disease Ontology:DOID:0081134)", "pathway": " (rno:65041)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140545 ATP-dependent protein disaggregase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0034605 cellular response to heat;GO:0039529 RIG-I signaling pathway;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WTT2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY65-1", "uniprot_id": [ { "id": "ARFP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY65", "type": "external" } ], "mass": 37773.0, "length": 341, "protein_name": "Arfaptin-2", "gene_name": "Arfip2", "organism": "Rat", "refseq_name": "arfaptin-2", "refseq_ac": [ { "id": "NP_001004222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004222", "type": "external" } ], "gene_names_uniprotkb": "Arfip2", "gene_names_refseq": "Arfip2; POR", "protein_names_uniprotkb": "Arfaptin-2; ADP-ribosylation factor-interacting protein 2", "protein_names_refseq": "ADP-ribosylation factor interacting protein 2 (arfaptin 2); ADP-ribosylation factor-interacting protein 2; arfaptin-2; partner of Rac1", "tax_id": 10116, "disease": "", "pathway": " (rno:293344); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15809304", "class_list": "", "function": "Arfaptin 2 phosphorylation at Ser260 by Akt inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment, [RefSeq, PubMed]; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0030742 GTP-dependent protein binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0030036 actin cytoskeleton organization;GO:0034497 protein localization to phagophore assembly site;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2P1-1", "uniprot_id": [ { "id": "CNNM2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2P1", "type": "external" } ], "mass": 96609.0, "length": 875, "protein_name": "Metal transporter CNNM2", "gene_name": "Cnnm2", "organism": "Rat", "refseq_name": "metal transporter CNNM2", "refseq_ac": [ { "id": "NP_001011942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011942", "type": "external" } ], "gene_names_uniprotkb": "Cnnm2; Acdp2", "gene_names_refseq": "Cnnm2", "protein_names_uniprotkb": "Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2", "protein_names_refseq": "ancient conserved domain-containing protein 2; cyclin-M2; metal transporter CNNM2", "tax_id": 10116, "disease": "renal hypomagnesemia 6 (Disease Ontology:DOID:0060884); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:294014)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+)., [UniProtKB]; Metal transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015095 magnesium ion transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0010960 magnesium ion homeostasis;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2P1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62845-1", "uniprot_id": [ { "id": "CNTN4_RAT", "url": "https://www.uniprot.org/uniprot/Q62845", "type": "external" } ], "mass": 113393.0, "length": 1026, "protein_name": "Contactin-4", "gene_name": "Cntn4", "organism": "Rat", "refseq_name": "contactin-4 precursor", "refseq_ac": [ { "id": "NP_446331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446331", "type": "external" } ], "gene_names_uniprotkb": "Cntn4", "gene_names_refseq": "Axcam; Big-2; Cntn4", "protein_names_uniprotkb": "Contactin-4; BIG-2; Brain-derived immunoglobulin superfamily protein 2", "protein_names_refseq": "axonal-associated cell adhesion molecule; brain-derived immunoglobulin superfamily protein 2; contactin-4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:116658); (R-RNO-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16806532;38843836;8586965", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0031175 neuron projection development;GO:0045665 negative regulation of neuron differentiation;GO:0050808 synapse organization;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62845-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q712U5-1", "uniprot_id": [ { "id": "ARP19_RAT", "url": "https://www.uniprot.org/uniprot/Q712U5", "type": "external" } ], "mass": 12293.0, "length": 112, "protein_name": "cAMP-regulated phosphoprotein 19", "gene_name": "Arpp19", "organism": "Rat", "refseq_name": "cAMP-regulated phosphoprotein 19 isoform b", "refseq_ac": [ { "id": "NP_113848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113848", "type": "external" } ], "gene_names_uniprotkb": "Arpp19", "gene_names_refseq": "Arpp-19; Arpp19", "protein_names_uniprotkb": "cAMP-regulated phosphoprotein 19; ARPP-19", "protein_names_refseq": "cAMP-regulated phosphoprotein 19 isoform b; cyclic AMP phosphoprotein, 19 kDa; cyclic AMP phosphoprotein, 19kD", "tax_id": 10116, "disease": "", "pathway": " (rno:60336); (R-RNO-2465910)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11279279;12221279;12944371;2158525;22673903", "class_list": "", "function": "ARPP-19 is an important link between NGF signaling and post-transcriptional control of neuronal gene expression., [RefSeq, PubMed]; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (By similarity). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (By similarity). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP43 expression by binding to the NGF-regulatory region of its mRNA (PubMed:12221279)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015459 potassium channel regulator activity;GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045722 positive regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q712U5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62736-1", "uniprot_id": [ { "id": "CALD1_RAT", "url": "https://www.uniprot.org/uniprot/Q62736", "type": "external" } ], "mass": 60584.0, "length": 531, "protein_name": "Non-muscle caldesmon", "gene_name": "Cald1", "organism": "Rat", "refseq_name": "non-muscle caldesmon isoform 2", "refseq_ac": [ { "id": "NP_037278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037278", "type": "external" } ], "gene_names_uniprotkb": "Cald1", "gene_names_refseq": "Cald1; l-Cad", "protein_names_uniprotkb": "Non-muscle caldesmon; CDM; L-caldesmon", "protein_names_refseq": "CDM; L-caldesmon; h-caldesmon; non-muscle caldesmon isoform 2; non-muscle caldesmon", "tax_id": 10116, "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207)", "pathway": " (rno:25687); (R-RNO-445355)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16289153;17200138;1986309;22158623;22673903;23077044;7876150", "class_list": "", "function": "Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration., [UniProtKB, PubMed]; CaD stabilizes the F-actin dynamics in spines, thereby enlarging the spine heads, whereas CaD knockdown decreases the spine-head size via destabilization of the F-actin dynamics., [RefSeq, PubMed]; Caldesmon is an important regulator of axon development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0006936 muscle contraction;GO:0051017 actin filament bundle assembly;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62736-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PT0-1", "uniprot_id": [ { "id": "DDX52_RAT", "url": "https://www.uniprot.org/uniprot/Q99PT0", "type": "external" } ], "mass": 67240.0, "length": 598, "protein_name": "Probable ATP-dependent RNA helicase DDX52", "gene_name": "AC105531.1; Ddx52; Synrg", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX52", "refseq_ac": [ { "id": "NP_445977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445977", "type": "external" } ], "gene_names_uniprotkb": "AC105531.1; Ddx52; Synrg; AC105531.1; Ddx52; Rok1; Synrg", "gene_names_refseq": "Ddx52; Rok1", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX52; 3.6.4.13; ATP-dependent RNA helicase ROK1-like; DEAD box protein 52; rROK1L", "protein_names_refseq": "ATP-dependent, RNA helicase; DEAD (Asp-Glu-Ala-Asp) box polypeptide 52; DEAD box protein 52; DEAD-box helicase 52; probable ATP-dependent RNA helicase DDX52; rROK1L", "tax_id": 10116, "disease": "", "pathway": " (rno:85432); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for efficient ribosome biogenesis. May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0048471 perinuclear region of cytoplasm;GO:0030130 clathrin coat of trans-Golgi network vesicle", "go_biological_process": "GO:0006364 rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0006897 endocytosis;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99PT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI94-1", "uniprot_id": [ { "id": "FIRRM_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI94", "type": "external" } ], "mass": 101794.0, "length": 905, "protein_name": "FIGNL1-interacting regulator of recombination and mitosis", "gene_name": "Firrm", "organism": "Rat", "refseq_name": "FIGNL1-interacting regulator of recombination and mitosis isoform 1", "refseq_ac": [ { "id": "NP_001017493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017493", "type": "external" } ], "gene_names_uniprotkb": "Firrm; LOC498265", "gene_names_refseq": "FLIP; Firrm", "protein_names_uniprotkb": "FIGNL1-interacting regulator of recombination and mitosis", "protein_names_refseq": "FIDGETIN-like-1 interacting protein; FIGNL1-interacting regulator of recombination and mitosis isoform 1; POLO1-associating protein; uncharacterized protein C1orf112 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498265); (R-RNO-2500257); (R-RNO-5693568); (R-RNO-912446)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms a complex with FIGL1, which regulates DNA double-strand break (DSB) repair via homologous recombination (HR). The FIGNL1-FIRRM complex is essential for resolution of homologous recombination intermediates in response to DNA interstrand cross-links (ICLs). The complex regulates HR by promoting disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (By similarity). It also regulates HR during meiosis by promoting dissociation of DMC1 filaments from DNA (By similarity). Within the complex, provides the ATPase activity to disassemble DMC1 and RAD51 filaments, while FIRRM directly binds single-stranded DNA to facilitate this unloading. Independently of FIRRM, slso acts as a regulator of PLK1 kinase activity at kinetochores that promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities. Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0051233 spindle midzone;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0036297 interstrand cross-link repair;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI94-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7B2-1", "uniprot_id": [ { "id": "CNPD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7B2", "type": "external" } ], "mass": 45544.0, "length": 408, "protein_name": "Protein CNPPD1", "gene_name": "Cnppd1", "organism": "Rat", "refseq_name": "protein CNPPD1", "refseq_ac": [ { "id": "NP_954543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954543", "type": "external" } ], "gene_names_uniprotkb": "Cnppd1", "gene_names_refseq": "Cnppd1; RGD735175", "protein_names_uniprotkb": "Protein CNPPD1", "protein_names_refseq": "hypothetical protein MGC:72616; protein CNPPD1", "tax_id": 10116, "disease": "", "pathway": " (rno:316530)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7S1-1", "uniprot_id": [ { "id": "ASAH1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7S1", "type": "external" } ], "mass": 44443.0, "length": 394, "protein_name": "Acid ceramidase", "gene_name": "Asah1", "organism": "Rat", "refseq_name": "acid ceramidase precursor", "refseq_ac": [ { "id": "NP_445859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445859", "type": "external" } ], "gene_names_uniprotkb": "Asah1", "gene_names_refseq": "Asah1; Asah", "protein_names_uniprotkb": "Acid ceramidase; 3.5.1.-; 3.5.1.23; ACDase; AC; Acid CDase; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase", "protein_names_refseq": "ACDase; AC; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; acid CDase; acid ceramidase precursor; acid ceramidase; acylsphingosine deacylase", "tax_id": 10116, "disease": "Farber lipogranulomatosis (Disease Ontology:DOID:0050464); spinal muscular atrophy with progressive myoclonic epilepsy (Disease Ontology:DOID:0111527); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (rno:84431); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1039/D0MO00044B;24090084;29393594;34106099", "class_list": "", "function": "Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Also has an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQJ6", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0003714 transcription corepressor activity;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0016922 nuclear receptor binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0016020 membrane;GO:0005764 lysosome;GO:0005576 extracellular region", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0030324 lung development;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6P7S1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HR5-1", "uniprot_id": [ { "id": "CACO1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HR5", "type": "external" } ], "mass": 77275.0, "length": 691, "protein_name": "Calcium-binding and coiled-coil domain-containing protein 1", "gene_name": "Calcoco1", "organism": "Rat", "refseq_name": "calcium-binding and coiled-coil domain-containing protein 1", "refseq_ac": [ { "id": "NP_631929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631929", "type": "external" } ], "gene_names_uniprotkb": "Calcoco1", "gene_names_refseq": "Calcoco1", "protein_names_uniprotkb": "Calcium-binding and coiled-coil domain-containing protein 1", "protein_names_refseq": "calcium-binding and coiled-coil domain-containing protein 1-like; calcium-binding and coiled-coil domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:246047)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R443", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6S3-1", "uniprot_id": [ { "id": "BSPRY_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6S3", "type": "external" } ], "mass": 49704.0, "length": 448, "protein_name": "B box and SPRY domain-containing protein", "gene_name": "Bspry; C5h9orf43", "organism": "Rat", "refseq_name": "B box and SPRY domain-containing protein isoform 1", "refseq_ac": [ { "id": "NP_071597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071597", "type": "external" } ], "gene_names_uniprotkb": "Bspry; C5h9orf43; Bspry; LOC500475", "gene_names_refseq": "Bspry", "protein_names_uniprotkb": "B box and SPRY domain-containing protein; Zetin-1", "protein_names_refseq": "B box and SPRY domain-containing protein isoform 1; b box and SPRY domain-containing protein; zetin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:500475); (rno:64027)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12615066", "class_list": "", "function": "May regulate epithelial calcium transport by inhibiting TRPV5 activity., [UniProtKB]; Zetin 1/rBSPRY and 14-3-3 protein interactions have a role at specialized submembrane domains, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBG7;Q9JKB6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0006816 calcium ion transport;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P6S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63149-1", "uniprot_id": [ { "id": "CADH4_RAT", "url": "https://www.uniprot.org/uniprot/Q63149", "type": "external" } ], "mass": 32912.0, "length": 296, "protein_name": "Cadherin-4", "gene_name": "Cdh4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdh4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-4; R-CAD; R-cadherin; Retinal cadherin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114588)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0045773 positive regulation of axon extension;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63149-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62698-1", "uniprot_id": [ { "id": "DC1L2_RAT", "url": "https://www.uniprot.org/uniprot/Q62698", "type": "external" } ], "mass": 54745.0, "length": 497, "protein_name": "Cytoplasmic dynein 1 light intermediate chain 2", "gene_name": "Dync1li2", "organism": "Rat", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 2 isoform 2", "refseq_ac": [ { "id": "NP_112288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112288", "type": "external" } ], "gene_names_uniprotkb": "Dync1li2; Dncli2", "gene_names_refseq": "Dncli2; Dync1li2; Lic2", "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 2; Dynein light intermediate chain 2, cytosolic; LIC-2; LIC53/55", "protein_names_refseq": "LIC-2 dynein light intermediate chain 53/55; LIC53/55; cytoplasmic dynein 1 light intermediate chain 2 isoform 2; cytoplasmic dynein 1 light intermediate chain 2; dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81655); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 13, "publication_count": 5, "publication_id_list": "10893222;22673903;26227614;30674581;7738094", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that both microtubule-associated DYNLT (dynein light chain Tctex-type 1) and cytoplasmic DYNLT (dynein 1 intermediate chain 2 DYNC1LI2) are equally able to bind to small GTPases Rab3D (Rab3d GTPase) and RagA (Ras-related GTP binding A)., [RefSeq, PubMed]; LIC1, through BicD2, is required for apical nuclear migration in neural progenitors. In newborn neurons, we observe specific roles for LIC1 in the multipolar to bipolar transition and glial-guided neuronal migration. In contrast, LIC2 contributes to a novel dynein role in the little-studied mode of migration, terminal somal translocation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005770 late endosome;GO:0000776 kinetochore;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:1990090 cellular response to nerve growth factor stimulus;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization;GO:0051642 centrosome localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62698-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PD4-1", "uniprot_id": [ { "id": "ARC1A_RAT", "url": "https://www.uniprot.org/uniprot/Q99PD4", "type": "external" } ], "mass": 41599.0, "length": 370, "protein_name": "Actin-related protein 2/3 complex subunit 1A", "gene_name": "Arpc1a", "organism": "Rat", "refseq_name": "actin-related protein 2/3 complex subunit 1A", "refseq_ac": [ { "id": "NP_112408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112408", "type": "external" } ], "gene_names_uniprotkb": "Arpc1a", "gene_names_refseq": "Arpc1a", "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 1A", "protein_names_refseq": "actin-related protein 2/3 complex subunit 1A; suppressor of profilin/p41 of actin-related complex 2/3", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:81824); (R-RNO-2029482); (R-RNO-3928662); (R-RNO-5663213); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0045202 synapse;GO:0035861 site of double-strand break;GO:0005885 Arp2/3 protein complex", "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99PD4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG97-1", "uniprot_id": [ { "id": "BTNL2_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG97", "type": "external" } ], "mass": 50767.0, "length": 454, "protein_name": "Butyrophilin-like protein 2", "gene_name": "Btnl2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Btnl2", "gene_names_refseq": "", "protein_names_uniprotkb": "Butyrophilin-like protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "berylliosis (Disease Ontology:DOID:10322); sarcoidosis (Disease Ontology:DOID:11335); Graves' disease (Disease Ontology:DOID:12361); Kawasaki disease (Disease Ontology:DOID:13378); coronary artery disease (Disease Ontology:DOID:3393); tuberculosis (Disease Ontology:DOID:399); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:309620); (R-RNO-8851680)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "Negative regulator of T-cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0042102 positive regulation of T cell proliferation;GO:0032743 positive regulation of interleukin-2 production;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG97-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64640-1", "uniprot_id": [ { "id": "ADK_RAT", "url": "https://www.uniprot.org/uniprot/Q64640", "type": "external" } ], "mass": 40134.0, "length": 361, "protein_name": "Adenosine kinase", "gene_name": "Adk", "organism": "Rat", "refseq_name": "adenosine kinase", "refseq_ac": [ { "id": "NP_037027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037027", "type": "external" } ], "gene_names_uniprotkb": "Adk", "gene_names_refseq": "AK; Adk", "protein_names_uniprotkb": "Adenosine kinase; 2.7.1.-; 2.7.1.20; AK; Adenosine 5'-phosphotransferase; N6,N6-dimethyladenosine kinase; N6-isopentenyladenosine kinase; N6-methyladenosine kinase", "protein_names_refseq": "N6,N6-dimethyladenosine kinase; N6-isopentenyladenosine kinase; N6-methyladenosine kinase; adenosine 5'-phosphotransferase; adenosine kinase", "tax_id": 10116, "disease": "hypermethioninemia due to adenosine kinase deficiency (Disease Ontology:DOID:0111038); peptic esophagitis (Disease Ontology:DOID:13976); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:25368); (R-RNO-74217); (R-RNO-9755088)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11833783;22345561;26983602;8917457;9070863", "class_list": "", "function": "ADK was associated with astrogliosis after TBI, its inhibition in reactive astrocytes ameliorated astrogliosis-induced neuronal death. Our findings extended the current knowledge on the role of ADK in astrogliosis, and also provided new evidence for the TBI treatment., [RefSeq, PubMed]; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives., [UniProtKB, UniProtKB]; Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication, [RefSeq, PubMed]; Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines. Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09162;Q642G1", "ec_number_list": [ { "id": "2.7.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.20", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004001 adenosine kinase activity;GO:0004136 deoxyadenosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046085 adenosine metabolic process;GO:0032261 purine nucleotide salvage;GO:0006175 dATP biosynthetic process;GO:0044209 AMP salvage;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64640-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZS3-1", "uniprot_id": [ { "id": "CAB45_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZS3", "type": "external" } ], "mass": 42075.0, "length": 361, "protein_name": "45 kDa calcium-binding protein", "gene_name": "Sdf4", "organism": "Rat", "refseq_name": "45 kDa calcium-binding protein", "refseq_ac": [ { "id": "NP_569096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569096", "type": "external" } ], "gene_names_uniprotkb": "Sdf4; Cab45", "gene_names_refseq": "Sdf4", "protein_names_uniprotkb": "45 kDa calcium-binding protein; Cab45; SDF-4; Stromal cell-derived factor 4", "protein_names_refseq": "45 kDa calcium-binding protein; SDF-4; cab45", "tax_id": 10116, "disease": "", "pathway": " (rno:155173)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17442889;18355758;19487699;22673903", "class_list": "", "function": "A membrane-associated isoform may be involved in the exocytosis of zymogens by pancreatic acini. May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment., [UniProtKB, PubMed]; In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b., [RefSeq, PubMed]; The results suggest a mechanism for Cab45b action that involves regulating the dynamic association of Munc18b with SNAREs to impact beta-cell granule exocytosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQW3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005770 late endosome", "go_biological_process": "GO:0045471 response to ethanol;GO:0045444 fat cell differentiation;GO:0099558 maintenance of synapse structure;GO:0017156 calcium-ion regulated exocytosis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91ZS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ9-1", "uniprot_id": [ { "id": "CEP70_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ9", "type": "external" } ], "mass": 68893.0, "length": 598, "protein_name": "Centrosomal protein of 70 kDa", "gene_name": "Cep70", "organism": "Rat", "refseq_name": "centrosomal protein of 70 kDa isoform 2", "refseq_ac": [ { "id": "NP_001415802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001415802", "type": "external" } ], "gene_names_uniprotkb": "Cep70", "gene_names_refseq": "Cep70", "protein_names_uniprotkb": "Centrosomal protein of 70 kDa; Cep70", "protein_names_refseq": "centrosomal protein 70kDa; centrosomal protein of 70 kDa isoform 2; centrosomal protein of 70 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:367153); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0006915 apoptotic process;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0060271 cilium assembly;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQQ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1I6-1", "uniprot_id": [ { "id": "ARHG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1I6", "type": "external" } ], "mass": 102597.0, "length": 919, "protein_name": "Rho guanine nucleotide exchange factor 1", "gene_name": "Arhgef1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arhgef1; Lsc", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 1; Lbc's second cousin", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 62 (Disease Ontology:DOID:0111991)", "pathway": " (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "20098430", "class_list": "", "function": "Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12 (By similarity). Mediates angiotensin-2-induced RhoA activation. In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001664 G protein-coupled receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007019 microtubule depolymerization;GO:0160221 Rho-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1I6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811A2-1", "uniprot_id": [ { "id": "BST2_RAT", "url": "https://www.uniprot.org/uniprot/Q811A2", "type": "external" } ], "mass": 19674.0, "length": 172, "protein_name": "Bone marrow stromal antigen 2", "gene_name": "Bst2", "organism": "Rat", "refseq_name": "bone marrow stromal antigen 2", "refseq_ac": [ { "id": "NP_937767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937767", "type": "external" } ], "gene_names_uniprotkb": "Bst2; Damp1", "gene_names_refseq": "Bst2; DAMP-1; Damp1", "protein_names_uniprotkb": "Bone marrow stromal antigen 2; BST-2; Protein DAMP-1", "protein_names_refseq": "BST-2; bone marrow stromal antigen 2; protein DAMP-1", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stomach cancer (Disease Ontology:DOID:10534); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); malignant astrocytoma (Disease Ontology:DOID:3069); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); acquired immunodeficiency syndrome (Disease Ontology:DOID:635)", "pathway": " (rno:378947); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12956872;19273615;20702620", "class_list": "", "function": "IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (By similarity). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0030336 negative regulation of cell migration;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811A2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIT6-1", "uniprot_id": [ { "id": "DESI2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIT6", "type": "external" } ], "mass": 21418.0, "length": 194, "protein_name": "Deubiquitinase DESI2", "gene_name": "Desi2", "organism": "Rat", "refseq_name": "deubiquitinase DESI2", "refseq_ac": [ { "id": "NP_001013895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013895", "type": "external" } ], "gene_names_uniprotkb": "Desi2; Fam152a; Pppde1", "gene_names_refseq": "CGI-146; DeSI-2; Desi2; Fam152a; PNAS-4; Pppde1", "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; DeSI-2; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2", "protein_names_refseq": "PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; S-depalmitoylase DESI2; deubiquitinase DESI2; family with sequence similarity 152, member A; palmitoyl protein thioesterase DESI2", "tax_id": 10116, "disease": "", "pathway": " (rno:289277)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;33794264", "class_list": "", "function": "Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Upregulation of PPPDE1 contributes to anorectal malformations via the mitochondrial apoptosis pathway during hindgut development in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH5-1", "uniprot_id": [ { "id": "DCTN2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH5", "type": "external" } ], "mass": 44148.0, "length": 402, "protein_name": "Dynactin subunit 2", "gene_name": "Dctn2", "organism": "Rat", "refseq_name": "dynactin subunit 2", "refseq_ac": [ { "id": "NP_001004239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004239", "type": "external" } ], "gene_names_uniprotkb": "Dctn2", "gene_names_refseq": "Dctn2", "protein_names_uniprotkb": "Dynactin subunit 2", "protein_names_refseq": "dynactin 2 (p50); dynactin subunit 2", "tax_id": 10116, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:299850); (R-RNO-2132295); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-8854518)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0007080 mitotic metaphase chromosome alignment;GO:0032402 melanosome transport;GO:0007052 mitotic spindle organization;GO:0071539 protein localization to centrosome;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VH46-1", "uniprot_id": [ { "id": "AFAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VH46", "type": "external" } ], "mass": 80752.0, "length": 731, "protein_name": "Actin filament-associated protein 1", "gene_name": "Afap1", "organism": "Rat", "refseq_name": "actin filament-associated protein 1", "refseq_ac": [ { "id": "NP_543176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543176", "type": "external" } ], "gene_names_uniprotkb": "Afap1; Afap", "gene_names_refseq": "Afap1; Afap", "protein_names_uniprotkb": "Actin filament-associated protein 1; 110 kDa actin filament-associated protein; AFAP-110", "protein_names_refseq": "110 kDa actin filament-associated protein; AFAP-110; actin filament-associated protein 1", "tax_id": 10116, "disease": "open-angle glaucoma (Disease Ontology:DOID:1067)", "pathway": " (rno:140935)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12114187;18577577;19540230;22673903;26340021;38843836", "class_list": "", "function": "AFAP-110 phosphorylation and/or dephosphorylation is involved in the regulation of podosome stability and lifespan., [RefSeq, PubMed]; AFAP1 is an essential downstream signaling component of TGF-beta1 for Src activation, CCN2 induction and collagen XIIa in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that Tks5 plays a central role in the recruitment of AFAP-110, p190RhoGAP, and cortactin to drive podosome formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0009966 regulation of signal transduction;GO:0007595 lactation;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VH46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6G2-1", "uniprot_id": [ { "id": "CF089_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6G2", "type": "external" } ], "mass": 39572.0, "length": 348, "protein_name": "Bombesin receptor-activated protein C6orf89 homolog", "gene_name": "C20h6orf89", "organism": "Rat", "refseq_name": "bombesin receptor-activated protein C6orf89 homolog", "refseq_ac": [ { "id": "NP_955411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955411", "type": "external" } ], "gene_names_uniprotkb": "C20h6orf89; RGD735065", "gene_names_refseq": "C20h6orf89; RGD735065", "protein_names_uniprotkb": "Bombesin receptor-activated protein C6orf89 homolog", "protein_names_refseq": "bombesin receptor-activated protein C6orf89 homolog; uncharacterized protein C6orf89 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:294311)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045787 positive regulation of cell cycle;GO:0042060 wound healing;GO:0050673 epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6G2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI03-1", "uniprot_id": [ { "id": "CO5A1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI03", "type": "external" } ], "mass": 183987.0, "length": 1840, "protein_name": "Collagen alpha-1(V) chain", "gene_name": "Col5a1", "organism": "Rat", "refseq_name": "collagen alpha-1(V) chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_604447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604447", "type": "external" } ], "gene_names_uniprotkb": "Col5a1", "gene_names_refseq": "Col5a1", "protein_names_uniprotkb": "Collagen alpha-1(V) chain", "protein_names_refseq": "collagen alpha 1 (V); collagen alpha-1(V) chain isoform 1 precursor; collagen alpha-1(V) chain; collagen, type V, alpha 1; procollagen, type V, alpha 1", "tax_id": 10116, "disease": "Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720)", "pathway": " (rno:85490); (R-RNO-1442490); (R-RNO-1566977); (R-RNO-1650814); (R-RNO-186797); (R-RNO-2022090); (R-RNO-216083); (R-RNO-3000171); (R-RNO-3000178); (R-RNO-419037); (R-RNO-8874081); (R-RNO-8948216)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "10852920;22673903", "class_list": "", "function": "Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0043394 proteoglycan binding;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005581 collagen trimer;GO:0005588 collagen type V trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0030199 collagen fibril organization;GO:0001568 blood vessel development;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JI03-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIG2-1", "uniprot_id": [ { "id": "C1QT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIG2", "type": "external" } ], "mass": 32042.0, "length": 281, "protein_name": "Complement C1q tumor necrosis factor-related protein 1", "gene_name": "C1qtnf1", "organism": "Rat", "refseq_name": "complement C1q tumor necrosis factor-related protein 1 precursor", "refseq_ac": [ { "id": "NP_001007676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007676", "type": "external" } ], "gene_names_uniprotkb": "C1qtnf1", "gene_names_refseq": "C1qtnf1; Ctrp1", "protein_names_uniprotkb": "Complement C1q tumor necrosis factor-related protein 1", "protein_names_refseq": "C1q and tumor necrosis factor related protein 1; complement C1q tumor necrosis factor-related protein 1 precursor; complement C1q tumor necrosis factor-related protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:303701)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16806199", "class_list": "", "function": "These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.[Ctrp1], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI32-1", "uniprot_id": [ { "id": "CAPZB_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI32", "type": "external" } ], "mass": 30629.0, "length": 272, "protein_name": "F-actin-capping protein subunit beta", "gene_name": "Capzb", "organism": "Rat", "refseq_name": "F-actin-capping protein subunit beta isoform 6", "refseq_ac": [ { "id": "NP_001005903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005903", "type": "external" } ], "gene_names_uniprotkb": "Capzb", "gene_names_refseq": "Capzb", "protein_names_uniprotkb": "F-actin-capping protein subunit beta; CapZ beta", "protein_names_refseq": "F-actin capping protein beta subunit; F-actin-capping protein subunit beta isoform 6; F-actin-capping protein subunit beta; capZ beta; capping actin protein of muscle Z-line beta subunit; capping protein (actin filament) muscle Z-line, beta", "tax_id": 10116, "disease": "dementia (Disease Ontology:DOID:1307); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:298584)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18683930;19343716;22673903;26237647;26429793;27185186", "class_list": "", "function": "Binding of CapZ to PtdIns(3)P, which is enriched in omegasomes, stimulates actin polymerization., [RefSeq, PubMed]; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The goal of this study was to test the hypothesis that actin filament assembly during cardiomyocyte growth is regulated by post-translational modifications (PTMs) of CapZbeta1., [RefSeq, PubMed]; With strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin, which was quantified on confocal images., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005903 brush border;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0031175 neuron projection development;GO:0000902 cell morphogenesis;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5XI32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4C0-1", "uniprot_id": [ { "id": "CAN5_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4C0", "type": "external" } ], "mass": 73065.0, "length": 640, "protein_name": "Calpain-5", "gene_name": "Capn5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Capn5", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpain-5; 3.4.22.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (rno:171495); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0006508 proteolysis;GO:0001541 ovarian follicle development;GO:0001553 luteinization;GO:0060014 granulosa cell differentiation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R4C0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SGD7-1", "uniprot_id": [ { "id": "CNKR3_RAT", "url": "https://www.uniprot.org/uniprot/Q5SGD7", "type": "external" } ], "mass": 61851.0, "length": 555, "protein_name": "Connector enhancer of kinase suppressor of ras 3", "gene_name": "Cnksr3", "organism": "Rat", "refseq_name": "connector enhancer of kinase suppressor of ras 3", "refseq_ac": [ { "id": "NP_001012061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012061", "type": "external" } ], "gene_names_uniprotkb": "Cnksr3; Prp4", "gene_names_refseq": "Cnksr3; Magi1; Prp4", "protein_names_uniprotkb": "Connector enhancer of kinase suppressor of ras 3; CNK homolog protein 3; CNK3; Connector enhancer of KSR 3; Maguin-like protein; Parturition-related protein 4", "protein_names_refseq": "CNK homolog protein 3; CNK3; connector enhancer of KSR 3; connector enhancer of kinase suppressor of ras 3; maguin-like protein; membrane-associated guanylate kinase-interacting protein-like 1; parturition-related protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:308113)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6VPP2", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0050808 synapse organization;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0010765 positive regulation of sodium ion transport;GO:2000651 positive regulation of sodium ion transmembrane transporter activity;GO:0033137 negative regulation of peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5SGD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC3-1", "uniprot_id": [ { "id": "CD37L_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC3", "type": "external" } ], "mass": 38315.0, "length": 335, "protein_name": "Hsp90 co-chaperone Cdc37-like 1", "gene_name": "Cdc37l1", "organism": "Rat", "refseq_name": "hsp90 co-chaperone Cdc37-like 1", "refseq_ac": [ { "id": "NP_001011941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011941", "type": "external" } ], "gene_names_uniprotkb": "Cdc37l1", "gene_names_refseq": "Cdc37l1; Cdc37l", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37-like 1", "protein_names_refseq": "cell division cycle 37 homolog-like 1; hsp90 co-chaperone Cdc37-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:293886); (R-RNO-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIC3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2M6-1", "uniprot_id": [ { "id": "DCAF8_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2M6", "type": "external" } ], "mass": 66156.0, "length": 591, "protein_name": "DDB1- and CUL4-associated factor 8", "gene_name": "Dcaf8", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 8 isoform 1", "refseq_ac": [ { "id": "NP_001014253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014253", "type": "external" } ], "gene_names_uniprotkb": "Dcaf8; Wdr42a", "gene_names_refseq": "Dcaf8; RGD1308513; Wdr42a", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 8; WD repeat-containing protein 42A", "protein_names_refseq": "DDB1- and CUL4-associated factor 8 isoform 1; WD repeat domain 42A; WD repeat-containing protein 42A", "tax_id": 10116, "disease": "giant axonal neuropathy 2 (Disease Ontology:DOID:0090069)", "pathway": " (rno:364050); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0014904 myotube cell development;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2M6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2X5-1", "uniprot_id": [ { "id": "ACK1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2X5", "type": "external" } ], "mass": 115068.0, "length": 1040, "protein_name": "Activated CDC42 kinase 1", "gene_name": "Tnk2", "organism": "Rat", "refseq_name": "activated CDC42 kinase 1 isoform 1", "refseq_ac": [ { "id": "NP_001008337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008337", "type": "external" } ], "gene_names_uniprotkb": "Tnk2; Ack1", "gene_names_refseq": "Tnk2", "protein_names_uniprotkb": "Activated CDC42 kinase 1; 2.7.10.2; 2.7.11.1; ACK-1; Tyrosine kinase non-receptor protein 2", "protein_names_refseq": "ACK-1; activated CDC42 kinase 1 isoform 1; activated CDC42 kinase 1; activated p21cdc42Hs kinase; tyrosine kinase non-receptor protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:303882); (R-RNO-9842663)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363', thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007286 spermatid development;GO:2000369 regulation of clathrin-dependent endocytosis;GO:0016310 phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2X5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFG6-1", "uniprot_id": [ { "id": "CA2D2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFG6", "type": "external" } ], "mass": 130776.0, "length": 1157, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-2", "gene_name": "Cacna2d2", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_783182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783182", "type": "external" } ], "gene_names_uniprotkb": "Cacna2d2", "gene_names_refseq": "Cacna2d2", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2", "protein_names_refseq": "calcium channel, voltage dependent, alpha2/delta subunit 2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform 1 precursor; voltage-dependent calcium channel subunit alpha-2/delta-2; voltage-gated calcium channel subunit alpha-2/delta-2", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:300992); (R-RNO-112308); (R-RNO-422356); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "12606261;16134135;16636499;24055266", "class_list": "", "function": "The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis (By similarity)., [UniProtKB]; The alpha2delta-2 subunit is also found in brain regions known to be involved in olfaction, somatic motor control, fluid homeostasis, ingestive and defensive behaviors, neuroendocrine functions, and circadian rhythm., [RefSeq, PubMed]; The level of the alpha1C (Cacna1c) (Cav1.2) protein was decreased (approximately 0.5-fold) and that of alpha2 delta-1 (Cacna2d1) was increased (approximately 2-fold) in the atrium compared with the ventricle, [RefSeq, PubMed]; There was no difference in the mRNA expression of alpha2delta-2 (Cacna2d2) between the BRL group and CHF control group (0.264 +/- 0.005 vs. 0.243 +/- 0.017, P>0.05), which was also higher than in the normal control group (0.137 +/- 0.013, P<0.01)., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005891 voltage-gated calcium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0007528 neuromuscular junction development;GO:0040014 regulation of multicellular organism growth;GO:0006816 calcium ion transport;GO:0046622 positive regulation of organ growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CFG6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N4-1", "uniprot_id": [ { "id": "BPNT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1N4", "type": "external" } ], "mass": 33174.0, "length": 308, "protein_name": "3'(2'),5'-bisphosphate nucleotidase 1", "gene_name": "Bpnt1", "organism": "Rat", "refseq_name": "3'(2'),5'-bisphosphate nucleotidase 1", "refseq_ac": [ { "id": "NP_741987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741987", "type": "external" } ], "gene_names_uniprotkb": "Bpnt1; Sal3", "gene_names_refseq": "Bpnt1; RnPIP; Sal3", "protein_names_uniprotkb": "3'(2'),5'-bisphosphate nucleotidase 1; 3'-phosphoadenosine 5'-phosphate phosphatase; 3.1.3.57; 3.1.3.7; BPntase 1; Bisphosphate 3'-nucleotidase 1; Inositol-polyphosphate 1-phosphatase; PAP phosphatase; RnPIP; scHAL2 analogous 3", "protein_names_refseq": "3'(2'),5'-bisphosphate nucleotidase 1; 3'-phosphoadenosine 5'-phosphate phosphatase; BPntase 1; PAP phosphatase; PAP-inositol 1,4-phosphatase; PIP; bisphosphate 3'-nucleotidase 1; inositol-polyphosphate 1-phosphatase; scHAL2 analogous 3", "tax_id": 10116, "disease": "", "pathway": " (rno:64473); (R-RNO-156584)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10347153;11812139", "class_list": "", "function": "Phosphatase that converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Is also able to hydrolyze inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but is not active on AMP, 3'-AMP, fructose-1,6-bisphosphate, Ins(1)P, Ins(2)P and Ins(1,4,5)P3. Probably prevents the toxic accumulation of PAP, a compound which inhibits a variety of proteins, including PAPS-utilizing enzymes such as sulfotransferases, and RNA processing enzymes. Could also play a role in inositol recycling and phosphoinositide metabolism., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.57", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.57", "type": "external" }, { "id": "3.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.7", "type": "external" } ], "go_molecular_function": "GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity;GO:0000287 magnesium ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MGA9-1", "uniprot_id": [ { "id": "BRD2_RAT", "url": "https://www.uniprot.org/uniprot/Q6MGA9", "type": "external" } ], "mass": 88051.0, "length": 798, "protein_name": "Bromodomain-containing protein 2", "gene_name": "Brd2", "organism": "Rat", "refseq_name": "bromodomain-containing protein 2", "refseq_ac": [ { "id": "NP_997660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997660", "type": "external" } ], "gene_names_uniprotkb": "Brd2; Ring3", "gene_names_refseq": "Brd2; Ring3", "protein_names_uniprotkb": "Bromodomain-containing protein 2; Protein RING3", "protein_names_refseq": "bromodomain-containing protein 2", "tax_id": 10116, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma (Disease Ontology:DOID:1909); photosensitivity disease (Disease Ontology:DOID:3159); juvenile myoclonic epilepsy (Disease Ontology:DOID:4890); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (rno:294276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin. In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation. Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0140033 acetylation-dependent protein binding;GO:0140566 histone reader activity;GO:0140011 histone H4K12ac reader activity;GO:0140012 histone H4K5ac reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MGA9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZZ9-1", "uniprot_id": [ { "id": "ARF_RAT", "url": "https://www.uniprot.org/uniprot/Q8QZZ9", "type": "external" } ], "mass": 17307.0, "length": 160, "protein_name": "Tumor suppressor ARF", "gene_name": "Cdkn2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdkn2a; P16ink4a", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor suppressor ARF; ARF; Alternative reading frame; Cyclin-dependent kinase inhibitor 2A; p19ARF", "protein_names_refseq": "", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); pre-malignant neoplasm (Disease Ontology:DOID:0060071); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma and neural system tumor syndrome (Disease Ontology:DOID:0111511); dysplastic nevus syndrome (Disease Ontology:DOID:10041); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); leukemia (Disease Ontology:DOID:1240); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); vascular disease (Disease Ontology:DOID:178); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); neurilemmoma (Disease Ontology:DOID:3192); rhabdomyosarcoma (Disease Ontology:DOID:3247); germinoma (Disease Ontology:DOID:3304); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); sarcomatoid mesothelioma (Disease Ontology:DOID:4488); pancreatic carcinoma (Disease Ontology:DOID:4905); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); uterine carcinosarcoma (Disease Ontology:DOID:6171); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); neuroblastoma (Disease Ontology:DOID:769); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25163)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9032263", "class_list": "", "function": "Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity)., [UniProtKB, UniProtKB]; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0051059 NF-kappaB binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:1904750 negative regulation of protein localization to nucleolus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QZZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIU7-1", "uniprot_id": [ { "id": "CA105_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIU7", "type": "external" } ], "mass": 23080.0, "length": 199, "protein_name": "Uncharacterized protein C1orf105 homolog", "gene_name": "C13h1orf105", "organism": "Rat", "refseq_name": "uncharacterized protein C1orf105 homolog isoform 1", "refseq_ac": [ { "id": "NP_001014152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014152", "type": "external" } ], "gene_names_uniprotkb": "C13h1orf105; RGD1309106", "gene_names_refseq": "C13h1orf105; RGD1309106", "protein_names_uniprotkb": "Uncharacterized protein C1orf105 homolog", "protein_names_refseq": "uncharacterized protein C1orf105 homolog isoform 1; uncharacterized protein C1orf105 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360864)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIU7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG45-1", "uniprot_id": [ { "id": "ARK72_RAT", "url": "https://www.uniprot.org/uniprot/Q8CG45", "type": "external" } ], "mass": 40675.0, "length": 367, "protein_name": "Aflatoxin B1 aldehyde reductase member 2", "gene_name": "Akr7a2", "organism": "Rat", "refseq_name": "aflatoxin B1 aldehyde reductase member 2", "refseq_ac": [ { "id": "NP_599234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599234", "type": "external" } ], "gene_names_uniprotkb": "Akr7a2; Afar2; Aiar", "gene_names_refseq": "Aiar; Akr7a2", "protein_names_uniprotkb": "Aflatoxin B1 aldehyde reductase member 2; 1.1.1.n11; SSA reductase; Succinic semialdehyde reductase; rAFAR2", "protein_names_refseq": "SSA reductase; aflatoxin B1 aldehyde reductase member 2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); rAFAR2; succinic semialdehyde reductase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (rno:171445); (R-RNO-5423646)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10965890;12071861;12879023;22673903", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Acts as a 2-carboxybenzaldehyde reductase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P765;Q8K435;Q9JM82", "ec_number_list": [ { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.n11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n11", "type": "external" } ], "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0019119 phenanthrene-9,10-epoxide hydrolase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005790 smooth endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CG45-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIT0-1", "uniprot_id": [ { "id": "CDKL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIT0", "type": "external" } ], "mass": 57135.0, "length": 507, "protein_name": "Cyclin-dependent kinase-like 2", "gene_name": "Cdkl2", "organism": "Rat", "refseq_name": "cyclin-dependent kinase-like 2", "refseq_ac": [ { "id": "NP_001012035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012035", "type": "external" } ], "gene_names_uniprotkb": "Cdkl2", "gene_names_refseq": "Cdkl2", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 2; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase-like 2 (CDC2-related kinase); cyclin-dependent kinase-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:305242)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP90-1", "uniprot_id": [ { "id": "ARRD4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP90", "type": "external" } ], "mass": 33275.0, "length": 300, "protein_name": "Arrestin domain-containing protein 4", "gene_name": "Arrdc4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arrdc4; Ab1-209", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin domain-containing protein 4; Liver regeneration-related protein LRRG041/LRRGT00117", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:293019)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0051443 positive regulation of ubiquitin-protein transferase activity;GO:0032728 positive regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TP90-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI33-1", "uniprot_id": [ { "id": "CIDEC_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI33", "type": "external" } ], "mass": 27214.0, "length": 238, "protein_name": "Lipid transferase CIDEC", "gene_name": "Cidec", "organism": "Rat", "refseq_name": "lipid transferase CIDEC isoform 1", "refseq_ac": [ { "id": "NP_001019504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019504", "type": "external" } ], "gene_names_uniprotkb": "Cidec; Fsp27", "gene_names_refseq": "Cidec", "protein_names_uniprotkb": "Lipid transferase CIDEC; Cell death-inducing DFFA-like effector protein C; Fat-specific protein FSP27", "protein_names_refseq": "cell death activator CIDE-3; cell death-inducing DFFA-like effector protein C; fat-specific protein FSP27; lipid transferase CIDEC isoform 1; lipid transferase CIDEC", "tax_id": 10116, "disease": "familial partial lipodystrophy type 5 (Disease Ontology:DOID:0070203)", "pathway": " (rno:500292); (R-RNO-8964572)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21996045;22752386;23233732;27716232;29078040;31205943;33655702", "class_list": "", "function": "CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy., [RefSeq, PubMed]; Esveratrol can correct fat formation and storage imbalance status by up-regulating FSP27 and down-regulating PPAR-gamma expression level, ameliorating insulin sensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; FSP27 is associated with rat lipid metabolism and its expression varies with energy and nutrient supply. It can inhibit excessive hydrolysis and fat accumulation by regulating HSL and ATGL expression and by mediating LDs formation. Publication Status: Online-Only, [RefSeq, PubMed]; From these findings, it can be concluded that Fsp27 expression suppressed HSC activation in vitro and liver fibrogenesis in vivo, [RefSeq, PubMed]; Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (By similarity). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (By similarity). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (By similarity). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (PubMed:23233732). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Long-term intermittent fasting, in contrast to other dietary manipulations, significantly up-regulated Fsp27 gene expression in white adipose tissue., [RefSeq, PubMed]; Study shows that cell death-inducing DFF45-like effector C gene silencing alleviates pulmonary vascular remodeling in a type 2 diabetic rat model. The CIDEC/5' monophosphate-activated protein kinase signaling pathway could be a potential therapeutic candidate against pulmonary vascular diseases in type 2 diabetes patients., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding;GO:0070300 phosphatidic acid binding;GO:0120013 lipid transfer activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0090209 negative regulation of triglyceride metabolic process;GO:0006915 apoptotic process;GO:0050995 negative regulation of lipid catabolic process;GO:0097194 execution phase of apoptosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5XI33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MGB5-1", "uniprot_id": [ { "id": "DHB8_RAT", "url": "https://www.uniprot.org/uniprot/Q6MGB5", "type": "external" } ], "mass": 26791.0, "length": 259, "protein_name": "(3R)-3-hydroxyacyl-CoA dehydrogenase", "gene_name": "Hsd17b8", "organism": "Rat", "refseq_name": "(3R)-3-hydroxyacyl-CoA dehydrogenase", "refseq_ac": [ { "id": "NP_997694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997694", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b8", "gene_names_refseq": "Fabgl; Hsd17b8; Ke6; RING2", "protein_names_uniprotkb": "(3R)-3-hydroxyacyl-CoA dehydrogenase; 1.1.1.239; 1.1.1.62; 1.1.1.n12; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; Estradiol 17-beta-dehydrogenase 8; KAR alpha subunit; Testosterone 17-beta-dehydrogenase 8", "protein_names_refseq": "(3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; KAR alpha subunit; estradiol 17-beta-dehydrogenase 8; testosterone 17-beta-dehydrogenase 8", "tax_id": 10116, "disease": "", "pathway": " (rno:361802); (R-RNO-75105)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15060004;22673903;9712896", "class_list": "", "function": "Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "4.2.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107", "type": "external" }, { "id": "4.2.1.119", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" } ], "go_molecular_function": "GO:0048038 quinone binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0070404 NADH binding;GO:0106386 (3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0016020 membrane;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0006703 estrogen biosynthetic process;GO:0008209 androgen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MGB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63517-1", "uniprot_id": [ { "id": "CENPI_RAT", "url": "https://www.uniprot.org/uniprot/Q63517", "type": "external" } ], "mass": 85651.0, "length": 745, "protein_name": "Centromere protein I", "gene_name": "Cenpi", "organism": "Rat", "refseq_name": "centromere protein I", "refseq_ac": [ { "id": "NP_037087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037087", "type": "external" } ], "gene_names_uniprotkb": "Cenpi; Fshprh1; Lrpr1", "gene_names_refseq": "Cenpi; Fshprh1; LRPR1; RNALRP", "protein_names_uniprotkb": "Centromere protein I; CENP-I; FSH primary response protein 1; Follicle-stimulating hormone primary response protein; Leucine-rich primary response protein 1", "protein_names_refseq": "CENP-I; FSH primary response 1; FSH primary response protein 1; Follicle stimulating hormone primary response gene 1 (Leucine - rich primary resonse gene 1); centromere protein I; follicle-stimulating hormone primary response protein; leucine-rich primary response protein 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hepatocellular adenoma (Disease Ontology:DOID:0050868); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); asbestosis (Disease Ontology:DOID:10320); stomach cancer (Disease Ontology:DOID:10534); familial hyperlipidemia (Disease Ontology:DOID:1168); morbid obesity (Disease Ontology:DOID:11981); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug-induced hepatitis (Disease Ontology:DOID:2044); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); extrinsic allergic alveolitis (Disease Ontology:DOID:841); oral cavity cancer (Disease Ontology:DOID:8618); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25448); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "7758824", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0005634 nucleus", "go_biological_process": "GO:0042699 follicle-stimulating hormone signaling pathway;GO:0034080 CENP-A containing chromatin assembly;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63517-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU9-1", "uniprot_id": [ { "id": "CNOT6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU9", "type": "external" } ], "mass": 63304.0, "length": 557, "protein_name": "CCR4-NOT transcription complex subunit 6", "gene_name": "Cnot6", "organism": "Rat", "refseq_name": "CCR4-NOT transcription complex subunit 6", "refseq_ac": [ { "id": "NP_001380807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380807", "type": "external" } ], "gene_names_uniprotkb": "Cnot6; Ccr4", "gene_names_refseq": "CCR4; Cnot6; RGD1310783", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 6; 3.1.13.4; CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase", "protein_names_refseq": "CCR4-NOT transcription complex subunit 6; carbon catabolite repressor protein 4 homolog; cytoplasmic deadenylase", "tax_id": 10116, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": " (rno:287249); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004532 RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030014 CCR4-NOT complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0008284 positive regulation of cell population proliferation;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXU9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y55-1", "uniprot_id": [ { "id": "CLD16_RAT", "url": "https://www.uniprot.org/uniprot/Q91Y55", "type": "external" } ], "mass": 26091.0, "length": 235, "protein_name": "Claudin-16", "gene_name": "Cldn16", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cldn16", "gene_names_refseq": "", "protein_names_uniprotkb": "Claudin-16; PLCN-1; Paracellin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "renal hypomagnesemia 3 (Disease Ontology:DOID:0060880); hypertension (Disease Ontology:DOID:10763); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (rno:155268)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11729235;15496416", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:15496416). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0030165 PDZ domain binding;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0051928 positive regulation of calcium ion transport;GO:0070293 renal absorption;GO:0070633 transepithelial transport;GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91Y55-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVS9-1", "uniprot_id": [ { "id": "CLOCK_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVS9", "type": "external" } ], "mass": 97004.0, "length": 862, "protein_name": "Circadian locomoter output cycles protein kaput", "gene_name": "Clock", "organism": "Rat", "refseq_name": "circadian locomoter output cycles protein kaput isoform S", "refseq_ac": [ { "id": "NP_001276761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276761", "type": "external" } ], "gene_names_uniprotkb": "Clock; LOC100911602", "gene_names_refseq": "Clock", "protein_names_uniprotkb": "Circadian locomoter output cycles protein kaput; 2.3.1.48; rCLOCK", "protein_names_refseq": "circadian locomoter output cycles kaput; circadian locomoter output cycles protein kaput isoform S; circadian locomoter output cycles protein kaput; rCLOCK", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); cholestasis (Disease Ontology:DOID:13580); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312); sleep disorder (Disease Ontology:DOID:535); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:60447)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10095082;34440369;34906901;35870088;37381033;38035406", "class_list": "", "function": "Rhythmic Regulation of DNA Methylation Factors and Core-Clock Genes in Brain Structures Activated by Cocaine or Sucrose: Potential Role of Chromatin Remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Rs2253820 Variant Controls Blood Pressure Dip After Stroke by Increasing CLOCK-BMAL1 Expression., [RefSeq, PubMed]; Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression., [RefSeq, PubMed]; The CLOCK protein regulates insulin secretion related with L-type calcium channels in rat pancreatic beta cells. Erratum:[Biochem Biophys Res Commun. 2022 Mar 5;595:96. doi: 10.1016/j.bbrc.2022.01.031. PMID: 35101272], [RefSeq, PubMed]; The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates the circadian expression of ICAM1, VCAM1, CCL2, THPO and MPL and also acts as an enhancer of the transactivation potential of NF-kappaB. Plays an important role in the homeostatic regulation of sleep. The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3'. The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3'. CLOCK has an intrinsic acetyltransferase activity, which enables circadian chromatin remodeling by acetylating histones and nonhistone proteins, including its own partner BMAL1. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) via the acetylation of multiple lysine residues located in its hinge region. The acetyltransferase activity of CLOCK is as important as its transcription activity in circadian control. Acetylates metabolic enzymes IMPDH2 and NDUFA9 in a circadian manner. Facilitated by BMAL1, rhythmically interacts and acetylates argininosuccinate synthase 1 (ASS1) leading to enzymatic inhibition of ASS1 as well as the circadian oscillation of arginine biosynthesis and subsequent ureagenesis (By similarity). Drives the circadian rhythm of blood pressure through transcriptional activation of ATP1B1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ziwuliuzhu Acupuncture Modulates Clock mRNA, Bmal1 mRNA and Melatonin in Insomnia Rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920Y1", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:1990513 CLOCK-BMAL transcription complex;GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051775 response to redox state", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XID7-1", "uniprot_id": [ { "id": "ARMX3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XID7", "type": "external" } ], "mass": 42553.0, "length": 379, "protein_name": "Armadillo repeat-containing X-linked protein 3", "gene_name": "Armcx3", "organism": "Rat", "refseq_name": "armadillo repeat-containing X-linked protein 3", "refseq_ac": [ { "id": "NP_001014295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014295", "type": "external" } ], "gene_names_uniprotkb": "Armcx3", "gene_names_refseq": "Armcx3", "protein_names_uniprotkb": "Armadillo repeat-containing X-linked protein 3", "protein_names_refseq": "armadillo repeat-containing X-linked protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:367902); (R-RNO-9013404)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19304657;22673903", "class_list": "", "function": "Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sox10 is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008104 intracellular protein localization;GO:0007005 mitochondrion organization;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XID7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ4-1", "uniprot_id": [ { "id": "CE57L_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ4", "type": "external" } ], "mass": 50274.0, "length": 430, "protein_name": "Centrosomal protein CEP57L1", "gene_name": "Cep57l1", "organism": "Rat", "refseq_name": "centrosomal protein CEP57L1 isoform X3", "refseq_ac": [ { "id": "XP_006256627", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256627", "type": "external" } ], "gene_names_uniprotkb": "Cep57l1; Cep57r", "gene_names_refseq": "Cep57l1; cep57R", "protein_names_uniprotkb": "Centrosomal protein CEP57L1; Centrosomal protein 57kDa-like protein 1; Centrosomal protein of 57 kDa-related protein; Cep57-related protein; Cep57R", "protein_names_refseq": "centrosomal protein CEP57L1 isoform X3", "tax_id": 10116, "disease": "", "pathway": " (rno:294519)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Centrosomal protein which may be required for microtubule attachment to centrosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUH3-1", "uniprot_id": [ { "id": "APOA5_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUH3", "type": "external" } ], "mass": 41427.0, "length": 367, "protein_name": "Apolipoprotein A-V", "gene_name": "Apoa5", "organism": "Rat", "refseq_name": "apolipoprotein A-V precursor", "refseq_ac": [ { "id": "NP_001264193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264193", "type": "external" } ], "gene_names_uniprotkb": "Apoa5; Rap3", "gene_names_refseq": "Apoa5; apo-AV; apoA-V", "protein_names_uniprotkb": "Apolipoprotein A-V; Apo-AV; ApoA-V; Apolipoprotein A5; Regeneration-associated protein 3", "protein_names_refseq": "apolipoprotein A-V precursor; apolipoprotein A-V; regeneration-associated protein 3", "tax_id": 10116, "disease": "hyperlipoproteinemia type V (Disease Ontology:DOID:1171); hyperlipoproteinemia type IV (Disease Ontology:DOID:1172); hypothyroidism (Disease Ontology:DOID:1459); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:140638); (R-RNO-381426); (R-RNO-8957275); (R-RNO-8963901)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "11577099;21115968;22673903;25938357;26505974;32602585", "class_list": "", "function": "ApoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion., [RefSeq, PubMed]; Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen., [RefSeq, PubMed]; Expression of ApoA5 and its function in the right ventricular failing and remodeling secondary to pulmonary hypertension., [RefSeq, PubMed]; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL (By similarity). May also be associated with chylomicrons (By similarity). Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVT8", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0019899 enzyme binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QUH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYJ2-1", "uniprot_id": [ { "id": "BOD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYJ2", "type": "external" } ], "mass": 18352.0, "length": 173, "protein_name": "Biorientation of chromosomes in cell division protein 1", "gene_name": "Bod1", "organism": "Rat", "refseq_name": "biorientation of chromosomes in cell division protein 1", "refseq_ac": [ { "id": "NP_001013876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013876", "type": "external" } ], "gene_names_uniprotkb": "Bod1; Fam44b", "gene_names_refseq": "Bod1; Fam44b; RGD1305622", "protein_names_uniprotkb": "Biorientation of chromosomes in cell division protein 1; Biorientation defective protein 1; Protein FAM44B", "protein_names_refseq": "biorientation defective protein 1; biorientation of chromosomes in cell division protein 1; family with sequence similarity 44, member B", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:287173)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005876 spindle microtubule;GO:0048188 Set1C/COMPASS complex;GO:0000940 outer kinetochore", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:1990758 mitotic sister chromatid biorientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYJ2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N34-1", "uniprot_id": [ { "id": "DFFB_RAT", "url": "https://www.uniprot.org/uniprot/Q99N34", "type": "external" } ], "mass": 40097.0, "length": 349, "protein_name": "DNA fragmentation factor subunit beta", "gene_name": "Dffb", "organism": "Rat", "refseq_name": "DNA fragmentation factor subunit beta", "refseq_ac": [ { "id": "NP_445814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445814", "type": "external" } ], "gene_names_uniprotkb": "Dffb; Cad", "gene_names_refseq": "Cad; Dffb", "protein_names_uniprotkb": "DNA fragmentation factor subunit beta; 3.-.-.-; CAD; Caspase-activated DNase; Caspase-activated deoxyribonuclease; DFF-40; DNA fragmentation factor 40 kDa subunit", "protein_names_refseq": "DFF-40; DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor subunit beta; DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, beta subunit; caspase-activated DNase; caspase-activated deoxyribonuclease", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:84359); (R-RNO-140342)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11425895;15167901;16642037;16767516", "class_list": "", "function": "DNA fragmentation in neuronal apoptosis is catalyzed by either CAD or DNase gamma depending on the differentiation state, [RefSeq, PubMed]; Data indicate increases in the nuclear levels of caspase-activated acinus and DNase and Endonuclease G (a caspase-independent endonuclease) in CA1 and CA3 pyramidal cell nuclei with different temporal patterns following an AMPA-insult., [RefSeq, PubMed]; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that Ebp1 contributes to inhibition of DNA fragmentation by caspase-activated DNase, and that nuclear Akt might contribute to suppressing apoptosis through interaction with Ebp1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0004520 DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0030263 apoptotic chromosome condensation;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process;GO:1902511 negative regulation of apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHY1-1", "uniprot_id": [ { "id": "CARL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHY1", "type": "external" } ], "mass": 149898.0, "length": 1373, "protein_name": "Capping protein, Arp2/3 and myosin-I linker protein 3", "gene_name": "Carmil3", "organism": "Rat", "refseq_name": "capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7", "refseq_ac": [ { "id": "XP_008768907", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768907", "type": "external" } ], "gene_names_uniprotkb": "Carmil3; Lrrc16b", "gene_names_refseq": "Carmil3; Lrrc16b", "protein_names_uniprotkb": "Capping protein, Arp2/3 and myosin-I linker protein 3; Capping protein regulator and myosin 1 linker protein 3; Leucine-rich repeat-containing protein 16B", "protein_names_refseq": "capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "21102520", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0098794 postsynapse", "go_biological_process": "GO:0016477 cell migration;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHY1-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T5-1", "uniprot_id": [ { "id": "ACY2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1T5", "type": "external" } ], "mass": 35314.0, "length": 312, "protein_name": "Aspartoacylase", "gene_name": "Aspa", "organism": "Rat", "refseq_name": "aspartoacylase", "refseq_ac": [ { "id": "NP_077375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077375", "type": "external" } ], "gene_names_uniprotkb": "Aspa", "gene_names_refseq": "Aspa", "protein_names_uniprotkb": "Aspartoacylase; 3.5.1.15; ACY-2; Aminoacylase-2", "protein_names_refseq": "ACY-2; aminoacylase-2; aspartoacylase", "tax_id": 10116, "disease": "Canavan disease (Disease Ontology:DOID:3613)", "pathway": " (rno:79251); (R-RNO-8963693)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12524181;15065127;16935940;17194761;21598311;24515258;27026062;38538326", "class_list": "", "function": "ASPA colocalized throughout the brain with CC1, a marker for oligodendrocytes, with 92-98% of CC1-positive cells also reactive with the ASPA antibody., [RefSeq, PubMed]; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids., [UniProtKB, PubMed]; Interaction of N-acetyl-L-aspartate accumulation due to ASPA deficiency with an unstable neuronal membrane potential caused by HCN1 deficiency was involved in tremor development., [RefSeq, PubMed]; Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease., [RefSeq, PubMed]; The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels. Publication Status: Online-Only, [RefSeq, PubMed]; The develomental increase of this enzyme in oligodendrocytes parallels CNS myelination., [RefSeq, PubMed]; This study demonistrated that aspartoacylase expression in the rat white matter central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ03", "ec_number_list": [ { "id": "3.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0019807 aspartoacylase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006083 acetate metabolic process;GO:0022010 central nervous system myelination;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R1T5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M828-1", "uniprot_id": [ { "id": "ADTRP_RAT", "url": "https://www.uniprot.org/uniprot/Q5M828", "type": "external" } ], "mass": 26904.0, "length": 230, "protein_name": "Androgen-dependent TFPI-regulating protein", "gene_name": "Adtrp", "organism": "Rat", "refseq_name": "androgen-dependent TFPI-regulating protein", "refseq_ac": [ { "id": "NP_001014166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014166", "type": "external" } ], "gene_names_uniprotkb": "Adtrp; Aa2-020", "gene_names_refseq": "Aa2-020; Adtrp; RGD1305679", "protein_names_uniprotkb": "Androgen-dependent TFPI-regulating protein; 3.1.-.-; FAHFA hydrolase ADTRP; Fatty acid esters of hydroxy fatty acids hydrolase ADTRP; Liver regeneration-related protein LRRG140", "protein_names_refseq": "FAHFA hydrolase ADTRP; androgen-dependent TFPI-regulating protein; androgen-dependent TPF1-regulating protein; fatty acid esters of hydroxy fatty acids hydrolase ADTRP; liver regeneration-related protein LRRG140", "tax_id": 10116, "disease": "", "pathway": " (rno:361228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP74", "ec_number_list": [ { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005901 caveola", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002686 negative regulation of leukocyte migration;GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M828-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q704S8-1", "uniprot_id": [ { "id": "CACP_RAT", "url": "https://www.uniprot.org/uniprot/Q704S8", "type": "external" } ], "mass": 70801.0, "length": 626, "protein_name": "Carnitine O-acetyltransferase", "gene_name": "Crat", "organism": "Rat", "refseq_name": "carnitine O-acetyltransferase", "refseq_ac": [ { "id": "NP_001004085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004085", "type": "external" } ], "gene_names_uniprotkb": "Crat", "gene_names_refseq": "Crat", "protein_names_uniprotkb": "Carnitine O-acetyltransferase; 2.3.1.137; 2.3.1.7; CAT; Carnitine acetylase; Carnitine acetyltransferase; CrAT", "protein_names_refseq": "CAT; carnitine O-acetyltransferase; carnitine acetylase; carnitine acetyltransferase", "tax_id": 10116, "disease": "neurodegeneration with brain iron accumulation (Disease Ontology:DOID:0110734)", "pathway": " (rno:311849); (R-RNO-389887); (R-RNO-70895); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15155769;16681386;19423663;22607230;24395925;26446791;27213235;34502162", "class_list": "", "function": "By performing two amino acid replacements a carnitine acetyltransferase can be converted into a pseudo carnitine palmitoyltransferase in terms of substrate specificity, [RefSeq, PubMed]; Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lipid-induced antagonism of CrAT might contribute to decreased PDH activity and glucose disposal in the context of obesity and diabetes., [RefSeq, PubMed]; Show for the first time that a single amino acid is able to determine the substrate specificity of carnitine acetyltransferase (CrAT), [RefSeq, PubMed]; This assay can be used to measure carnitine acetyltransferase activity in the same samples, and assays comparing choline O-acetyltransferase and CrAT show that carnitine acetyltransferase is highly active in neuronal tissues and in neuronal cell cultures, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0003997 acyl-CoA oxidase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0004092 carnitine O-acetyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase;GO:0046459 short-chain fatty acid metabolic process;GO:0051791 medium-chain fatty acid metabolic process;GO:0019254 carnitine metabolic process, CoA-linked", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q704S8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU61-1", "uniprot_id": [ { "id": "CLCC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU61", "type": "external" } ], "mass": 61174.0, "length": 541, "protein_name": "Chloride channel CLIC-like protein 1", "gene_name": "Clcc1", "organism": "Rat", "refseq_name": "chloride channel CLIC-like protein 1 precursor", "refseq_ac": [ { "id": "NP_596905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596905", "type": "external" } ], "gene_names_uniprotkb": "Clcc1; Mclc", "gene_names_refseq": "Clcc1; ERAC1; Mclc", "protein_names_uniprotkb": "Chloride channel CLIC-like protein 1; ER anion channel 1; ERAC1; Mid-1-related chloride channel protein 1", "protein_names_refseq": "ER anion channel 1; Mid-1-related chloride channel 1; chloride channel CLIC-like protein 1 precursor; chloride channel CLIC-like protein 1; mid-1-related chloride channel protein 1", "tax_id": 10116, "disease": "retinitis pigmentosa 32 (Disease Ontology:DOID:0110355)", "pathway": " (rno:170927)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11279057", "class_list": "", "function": "Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:11279057)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HQ5;Q8VIE8;Q8VIE9;Q8VIF0;Q8VIF1", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0006821 chloride transport;GO:0032469 endoplasmic reticulum calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WU61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2M4-1", "uniprot_id": [ { "id": "DECR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2M4", "type": "external" } ], "mass": 31292.0, "length": 292, "protein_name": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]", "gene_name": "Decr2; Nme4; Rab11fip3", "organism": "Rat", "refseq_name": "peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]", "refseq_ac": [ { "id": "NP_741993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741993", "type": "external" } ], "gene_names_uniprotkb": "Decr2; Nme4; Rab11fip3; Decr2; Nme4; Rab11fip3", "gene_names_refseq": "Dcrakl; Decr2; putativeperoxisomal24-dienoyl-CoAreductase", "protein_names_uniprotkb": "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; 1.3.1.124; 2,4-dienoyl-CoA reductase 2; DCR-AKL; pVI-AKL", "protein_names_refseq": "2,4-dienoyl CoA reductase 2, peroxisomal; 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal; DCR-AKL; pVI-AKL; peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; putative peroxisomal 2,4-dienoyl-CoA reductase; putative peroxisomal 24-dienoyl-CoA reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:303002); (rno:64461); (rno:685679); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10333503;11514237;29393594", "class_list": "", "function": "Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" } ], "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0009062 fatty acid catabolic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0006869 lipid transport;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7R8-1", "uniprot_id": [ { "id": "DHB12_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7R8", "type": "external" } ], "mass": 34841.0, "length": 312, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase", "gene_name": "Hsd17b12", "organism": "Rat", "refseq_name": "very-long-chain 3-oxoacyl-CoA reductase", "refseq_ac": [ { "id": "NP_114455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114455", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b12", "gene_names_refseq": "Hsd17b12", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase; 1.1.1.330; 1.1.1.62; 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12; KAR", "protein_names_refseq": "17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; KAR; estradiol 17-beta-dehydrogenase 12; smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3; very-long-chain 3-oxoacyl-CoA reductase", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84013); (R-RNO-193048); (R-RNO-75876)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21454685;38843836", "class_list": "", "function": "Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1B9", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0016491 oxidoreductase activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0009923 fatty acid elongase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0010811 positive regulation of cell-substrate adhesion;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P7R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XXR3-1", "uniprot_id": [ { "id": "ARHG6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XXR3", "type": "external" } ], "mass": 87013.0, "length": 772, "protein_name": "Rho guanine nucleotide exchange factor 6", "gene_name": "Arhgef6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arhgef6", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 6; Rac/Cdc42 guanine nucleotide exchange factor 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:363509); (R-RNO-193648); (R-RNO-416482); (R-RNO-446388); (R-RNO-8964616); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013420)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Acts as a RAC1 guanine nucleotide exchange factor (GEF)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0030027 lamellipodium", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XXR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63563-1", "uniprot_id": [ { "id": "ABCC9_RAT", "url": "https://www.uniprot.org/uniprot/Q63563", "type": "external" } ], "mass": 174118.0, "length": 1545, "protein_name": "ATP-binding cassette sub-family C member 9", "gene_name": "Abcc9", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 9", "refseq_ac": [ { "id": "NP_037172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037172", "type": "external" } ], "gene_names_uniprotkb": "Abcc9; Sur2", "gene_names_refseq": "Abcc9; Sur2", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 9; Sulfonylurea receptor 2", "protein_names_refseq": "ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; ATP-binding cassette, sub-family C, member 9-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 9; Sulfonylurea receptor 2", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); hypertrichotic osteochondrodysplasia Cantu type (Disease Ontology:DOID:0060569); intellectual disability and myopathy syndrome (Disease Ontology:DOID:0070600); Parkinsonism (Disease Ontology:DOID:0080855); dilated cardiomyopathy 1O (Disease Ontology:DOID:0110451); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:25560); (R-RNO-1296025); (R-RNO-382556); (R-RNO-5578775)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11927600;11967023;29275331;30074836;34455535;36336713;8630239", "class_list": "", "function": "Cardiac dysfunction in spontaneously hypertensive old rats is associated with a significant decrease of SUR2 expression., [RefSeq, PubMed]; D207E of Sue2 increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation., [RefSeq, PubMed]; Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B., [RefSeq, PubMed]; Lymphedema as first clinical presentation of Cantu Syndrome: reversed phenotyping after identification of gain-of-function variant in ABCC9., [RefSeq, PubMed]; Mesangial SUR2B as the possible first link in a chain of cellular events that culminates in MC contraction and altered extracellular matrix metabolism following exposure to sulfonylureas., [RefSeq, PubMed]; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Up-regulation of the KATP channel accelerates repolarization and shortens action potential duration during stress and exercise., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O89115", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0030017 sarcomere", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0072359 circulatory system development;GO:1903409 reactive oxygen species biosynthetic process;GO:0086003 cardiac muscle cell contraction;GO:1904880 response to hydrogen sulfide", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63563-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6T1-1", "uniprot_id": [ { "id": "C1S_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6T1", "type": "external" } ], "mass": 77071.0, "length": 688, "protein_name": "Complement C1s subcomponent", "gene_name": "C1s", "organism": "Rat", "refseq_name": "complement C1s subcomponent precursor", "refseq_ac": [ { "id": "NP_620255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620255", "type": "external" } ], "gene_names_uniprotkb": "C1s; r-gsp", "gene_names_refseq": "C1s; r-gsp", "protein_names_uniprotkb": "Complement C1s subcomponent; 3.4.21.42; C1 esterase; Complement component 1 subcomponent s", "protein_names_refseq": "C1 esterase; complement C1s subcomponent precursor; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent", "tax_id": 10116, "disease": "Ehlers-Danlos syndrome periodontal type 2 (Disease Ontology:DOID:0080987)", "pathway": " (rno:192262); (R-RNO-173623); (R-RNO-977606)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12393260;9524231", "class_list": "", "function": "Component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1S is activated following association of the C1 complex with immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. C1S is cleaved and activated by C1R to generate C1s subcomponent heavy and light chains. C1s subcomponent light chain then cleaves and activates C2 and C4, the next components of the classical complement pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine protease component of the complement C1 complex, which catalyzes cleavage and activation of C2 and C4, the next components of the classical complement pathway. Also cleaves IGFBP5 and thereby inhibits the trophic effects of IGF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that r-Gsp protein could not induce glial differentiation alone, and suggest that r-Gsp protein was secreted as a proenzyme and processed in culture medium [rGsp protein]., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O70542;Q8R099", "ec_number_list": [ { "id": "3.4.21.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.42", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005602 complement component C1 complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0051591 response to cAMP;GO:0051604 protein maturation;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P6T1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG7-1", "uniprot_id": [ { "id": "DDX59_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG7", "type": "external" } ], "mass": 65066.0, "length": 589, "protein_name": "Probable ATP-dependent RNA helicase DDX59", "gene_name": "Ddx59", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX59 isoform 2", "refseq_ac": [ { "id": "NP_001005535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005535", "type": "external" } ], "gene_names_uniprotkb": "Ddx59; Znhit5", "gene_names_refseq": "Ddx59", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX59; 3.6.4.13; DEAD box protein 59; Zinc finger HIT domain-containing protein 5", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 59; DEAD box protein 59; probable ATP-dependent RNA helicase DDX59 isoform 2; probable ATP-dependent RNA helicase DDX59; zinc finger HIT domain-containing protein 5", "tax_id": 10116, "disease": "orofaciodigital syndrome V (Disease Ontology:DOID:0060375)", "pathway": " (rno:289402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HG7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0L4-1", "uniprot_id": [ { "id": "CAND2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0L4", "type": "external" } ], "mass": 139673.0, "length": 1273, "protein_name": "Cullin-associated NEDD8-dissociated protein 2", "gene_name": "Cand2", "organism": "Rat", "refseq_name": "cullin-associated NEDD8-dissociated protein 2", "refseq_ac": [ { "id": "NP_852027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852027", "type": "external" } ], "gene_names_uniprotkb": "Cand2; Tip120b", "gene_names_refseq": "Cand2; Tip120B", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 2; Cullin-associated and neddylation-dissociated protein 2; TBP-interacting protein 120B; TBP-interacting protein b; TBP-interacting protein of 120 kDa B; p120 CAND2", "protein_names_refseq": "TBP-interacting protein 120B; TBP-interacting protein Tip120B; TBP-interacting protein b; TBP-interacting protein of 120 kDa B; cullin-associated NEDD8-dissociated protein 2; cullin-associated and neddylation-dissociated protein 2; p120 CAND2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:192226)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10441524;12692129", "class_list": "", "function": "Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0L3;Q9R0L5", "ec_number_list": [], "go_molecular_function": "GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R0L4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZL2-1", "uniprot_id": [ { "id": "CHST3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZL2", "type": "external" } ], "mass": 54018.0, "length": 474, "protein_name": "Carbohydrate sulfotransferase 3", "gene_name": "Chst3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chst3", "gene_names_refseq": "", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 3; 2.8.2.17; 2.8.2.21; C6ST-1; Chondroitin 6-O-sulfotransferase 1; GST-0; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0", "protein_names_refseq": "", "tax_id": 10116, "disease": "spondyloepiphyseal dysplasia with congenital joint dislocations (Disease Ontology:DOID:0050813); osteochondrodysplasia (Disease Ontology:DOID:2256); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:84468); (R-RNO-2022854); (R-RNO-2022870)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Catalyzes with a lower efficiency the sulfation of Gal residues of keratan sulfate, another glycosaminoglycan (By similarity). Can also catalyze the sulfation of the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides (By similarity). May play a role in the maintenance of naive T-lymphocytes in the spleen (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.17", "type": "external" }, { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008459 chondroitin 6-sulfotransferase activity;GO:0050698 proteoglycan sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0014012 peripheral nervous system axon regeneration;GO:0048678 response to axon injury;GO:0043029 T cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9QZL2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923K9-1", "uniprot_id": [ { "id": "A1CF_RAT", "url": "https://www.uniprot.org/uniprot/Q923K9", "type": "external" } ], "mass": 65620.0, "length": 594, "protein_name": "APOBEC1 complementation factor", "gene_name": "A1cf", "organism": "Rat", "refseq_name": "APOBEC1 complementation factor", "refseq_ac": [ { "id": "NP_596891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596891", "type": "external" } ], "gene_names_uniprotkb": "A1cf; Acf; Asp", "gene_names_refseq": "A1cft; A1cf; Acf; Apobec-1", "protein_names_uniprotkb": "APOBEC1 complementation factor; APOBEC1-stimulating protein", "protein_names_refseq": "APOBEC1 complementation factort; APOBEC1 complementation factor; APOBEC1-stimulating protein; Apobec-1 complementation factor, APOBEC-1 stimulating protein", "tax_id": 10116, "disease": "gout (Disease Ontology:DOID:13189)", "pathway": " (rno:170912); (R-RNO-72200); (R-RNO-75094)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10781591;11870221;14570923;17229474;20541536", "class_list": "", "function": "Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; N-terminal 320 amino acids of ACF retained RNA-binding selectivity and supported complementation of editing activity and in addition demonstrate a novel RNA-bridged multimerization of ACF., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH55;Q8CH56;Q8CH57;Q8CH58;Q924K3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003727 single-stranded RNA binding;GO:0140767 enzyme-substrate adaptor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030895 apolipoprotein B mRNA editing enzyme complex", "go_biological_process": "GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression;GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0016556 mRNA modification;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q923K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE64-1", "uniprot_id": [ { "id": "C1RL_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE64", "type": "external" } ], "mass": 51107.0, "length": 461, "protein_name": "Complement C1r subcomponent-like protein", "gene_name": "C1rl", "organism": "Rat", "refseq_name": "complement C1r subcomponent-like protein precursor", "refseq_ac": [ { "id": "NP_001002804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002804", "type": "external" } ], "gene_names_uniprotkb": "C1rl", "gene_names_refseq": "C1rl", "protein_names_uniprotkb": "Complement C1r subcomponent-like protein; 3.4.21.-; C1r-LP; C1r-like protein", "protein_names_refseq": "C1r-LP; C1r-like protein; complement C1r subcomponent-like protein precursor; complement C1r subcomponent-like protein; complement component 1, r subcomponent-like", "tax_id": 10116, "disease": "", "pathway": " (rno:408246)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0072562 blood microparticle", "go_biological_process": "GO:0045087 innate immune response;GO:0031638 zymogen activation;GO:0006958 complement activation, classical pathway;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62927-1", "uniprot_id": [ { "id": "CNGA1_RAT", "url": "https://www.uniprot.org/uniprot/Q62927", "type": "external" } ], "mass": 79228.0, "length": 683, "protein_name": "Cyclic nucleotide-gated channel alpha-1", "gene_name": "Cnga1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cnga1; Cncg1; Cncg", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated cation channel subunit alpha; cGMP-gated cation channel alpha-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinitis pigmentosa 49 (Disease Ontology:DOID:0110377); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:85259); (R-RNO-2485179); (R-RNO-2514859)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11764791;9045728;9142860", "class_list": "", "function": "Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08659", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005272 sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043195 terminal bouton;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051899 membrane depolarization;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62927-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNJ2-1", "uniprot_id": [ { "id": "ABCA7_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNJ2", "type": "external" } ], "mass": 237720.0, "length": 2170, "protein_name": "ATP-binding cassette sub-family A member 7", "gene_name": "Abca7", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family A member 7", "refseq_ac": [ { "id": "NP_997481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997481", "type": "external" } ], "gene_names_uniprotkb": "Abca7", "gene_names_refseq": "Abca7", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 7", "protein_names_refseq": "ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette, sub-family A, member 7; ATP-binding cassette, subfamily A (ABC1), member 7", "tax_id": 10116, "disease": "Alzheimer's disease 9 (Disease Ontology:DOID:0111364)", "pathway": " (rno:299609); (R-RNO-1369062)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12727224", "class_list": "", "function": "ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (By similarity). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (By similarity). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Rat ABCA7 is preferentially expressed in platelets and that its apparent molecular mass is 250kDa GeneRIF: Data show that rat ABCA7 is preferentially expressed in platelets and that its apparent molecular mass is 250kDa., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0005548 phospholipid transporter activity;GO:0034188 apolipoprotein A-I receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0007613 memory;GO:0008542 visual learning;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ81-1", "uniprot_id": [ { "id": "AGO2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZ81", "type": "external" } ], "mass": 97318.0, "length": 860, "protein_name": "Protein argonaute-2", "gene_name": "Ago2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ago2; AGO2; EIF2C2; Eif2c2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein argonaute-2; 3.1.26.n2; Argonaute RISC catalytic component 2; Argonaute2; Eukaryotic translation initiation factor 2C 2; GERp95; Golgi ER protein 95 kDa; Protein slicer; eIF-2C 2; eIF2C 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); glaucoma (Disease Ontology:DOID:1686); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (rno:59117); (R-RNO-203927); (R-RNO-426486); (R-RNO-426496); (R-RNO-5578749)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10512872;24882364", "class_list": "", "function": "Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.26.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" } ], "go_molecular_function": "GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZ81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64566-1", "uniprot_id": [ { "id": "AT2C1_RAT", "url": "https://www.uniprot.org/uniprot/Q64566", "type": "external" } ], "mass": 100500.0, "length": 919, "protein_name": "Calcium-transporting ATPase type 2C member 1", "gene_name": "Atp2c1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp2c1", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-transporting ATPase type 2C member 1; 7.2.2.10; ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; Ca(2+)/Mn(2+)-ATPase 2C1; SPCA1; Secretory pathway Ca(2+)-transporting ATPase type 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429)", "pathway": " (R-RNO-936837)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1380825", "class_list": "", "function": "ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64567", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0008544 epidermis development;GO:0030036 actin cytoskeleton organization;GO:0042998 positive regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64566-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGG1-1", "uniprot_id": [ { "id": "ABHEB_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGG1", "type": "external" } ], "mass": 22618.0, "length": 210, "protein_name": "Putative protein-lysine deacylase ABHD14B", "gene_name": "Abhd14b", "organism": "Rat", "refseq_name": "putative protein-lysine deacylase ABHD14B", "refseq_ac": [ { "id": "NP_001007665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007665", "type": "external" } ], "gene_names_uniprotkb": "Abhd14b", "gene_names_refseq": "Abhd14b", "protein_names_uniprotkb": "Putative protein-lysine deacylase ABHD14B; 2.3.1.-; Abhydrolase domain-containing protein 14B; Alpha/beta hydrolase domain-containing protein 14B", "protein_names_refseq": "abhydrolase domain-containing protein 14B; alpha/beta hydrolase domain-containing protein 14B; protein ABHD14B; putative protein-lysine deacylase ABHD14B", "tax_id": 10116, "disease": "", "pathway": " (rno:300983); (R-RNO-156584)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an atypical protein-lysine deacetylase in vitro. Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues. Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo. Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate. May activate transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0016787 hydrolase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DGG1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMA5-1", "uniprot_id": [ { "id": "APOB_RAT", "url": "https://www.uniprot.org/uniprot/Q7TMA5", "type": "external" } ], "mass": 536024.0, "length": 4743, "protein_name": "Apolipoprotein B-100", "gene_name": "Apob", "organism": "Rat", "refseq_name": "apolipoprotein B-100 precursor", "refseq_ac": [ { "id": "NP_062160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062160", "type": "external" } ], "gene_names_uniprotkb": "Apob; Aa1064; Ac1-060", "gene_names_refseq": "Aa1064; Ac1-060; Apo B-100; ApoB-100; ApoB-48; Apob", "protein_names_uniprotkb": "Apolipoprotein B-100; Apo B-100", "protein_names_refseq": "apolipoprotein B (including Ag(x) antigen); apolipoprotein B PI; apolipoprotein B-100 precursor; apolipoprotein B-100; apolipoprotein B-48", "tax_id": 10116, "disease": "familial hypobetalipoproteinemia 2 (Disease Ontology:DOID:0111061); familial hypobetalipoproteinemia 1 (Disease Ontology:DOID:0111062); sickle cell anemia (Disease Ontology:DOID:10923); familial hyperlipidemia (Disease Ontology:DOID:1168); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); beta thalassemia (Disease Ontology:DOID:12241); cardiovascular system disease (Disease Ontology:DOID:1287); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390); aortic valve stenosis (Disease Ontology:DOID:1712); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); bile duct cancer (Disease Ontology:DOID:4606); biliary tract cancer (Disease Ontology:DOID:4607); common bile duct neoplasm (Disease Ontology:DOID:4608); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54225); (R-RNO-202733); (R-RNO-3000471); (R-RNO-3000480); (R-RNO-3000497); (R-RNO-381426); (R-RNO-432142); (R-RNO-5686938); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866423); (R-RNO-8957275); (R-RNO-8963888); (R-RNO-8963901); (R-RNO-8964026); (R-RNO-8964038); (R-RNO-8964046); (R-RNO-9707616); (R-RNO-975634)", "pathway_count": 19, "publication_count": 8, "publication_id_list": "12493769;21454685;22673903;28694219;2911593;31176989;632283;6948299", "class_list": "", "function": "Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Enhanced VLDL TG secretion in the absence of hepatocyte ABCA1 is due to altered intracellular trafficking of apolipoprotein B (apoB), resulting in augmented TG addition to nascent VLDL., [RefSeq, PubMed]; Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats., [RefSeq, PubMed]; The developmental regulation of apoB mRNA editing is an autonomous cytodifferentiation function of small intestine and involves Cdx1, [RefSeq, PubMed]; This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-L and apoB-H. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the rat apoBL isoform is also found in rat liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-L protein is produced after RNA editing of the apoB-H transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 22, "predicted_n_glycosites": 21, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0035473 lipase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006629 lipid metabolic process;GO:0007283 spermatogenesis;GO:0007399 nervous system development;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TMA5-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811M5-1", "uniprot_id": [ { "id": "CO6_RAT", "url": "https://www.uniprot.org/uniprot/Q811M5", "type": "external" } ], "mass": 105114.0, "length": 934, "protein_name": "Complement component C6", "gene_name": "C6", "organism": "Rat", "refseq_name": "complement component C6 precursor", "refseq_ac": [ { "id": "NP_788263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788263", "type": "external" } ], "gene_names_uniprotkb": "C6", "gene_names_refseq": "C6", "protein_names_uniprotkb": "Complement component C6", "protein_names_refseq": "complement component 6; complement component C6 precursor; complement component C6", "tax_id": 10116, "disease": "complement component 6 deficiency (Disease Ontology:DOID:0060299); alcohol-associated liver disease (Disease Ontology:DOID:0070658); glomerulonephritis (Disease Ontology:DOID:2921); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:24237); (R-RNO-166665)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11870622;15568620;19833392;21575686;25011063", "class_list": "", "function": "C6 deficiency did not lead to neuroprotection after status epilepticus, [RefSeq, PubMed]; Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury., [RefSeq, PubMed]; Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes., [RefSeq, PubMed]; The membrane attack complex of complement induces caspase activation and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 6, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0043065 positive regulation of apoptotic process;GO:0055085 transmembrane transport;GO:0045766 positive regulation of angiogenesis;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q811M5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQR2-1", "uniprot_id": [ { "id": "ADAS_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQR2", "type": "external" } ], "mass": 71587.0, "length": 644, "protein_name": "Alkyldihydroxyacetonephosphate synthase, peroxisomal", "gene_name": "Agps", "organism": "Rat", "refseq_name": "alkyldihydroxyacetonephosphate synthase, peroxisomal", "refseq_ac": [ { "id": "NP_445802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445802", "type": "external" } ], "gene_names_uniprotkb": "Agps; Ads", "gene_names_refseq": "Adap-s; Adps; Ads; Agps", "protein_names_uniprotkb": "Alkyldihydroxyacetonephosphate synthase, peroxisomal; 2.5.1.26; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase", "protein_names_refseq": "alkyl-DHAP synthase; alkyl-dihydroxyacetonephosphate synthase; alkyldihydroxyacetone phosphate synthase; alkyldihydroxyacetonephosphate synthase, peroxisomal", "tax_id": 10116, "disease": "rhizomelic chondrodysplasia punctata type 3 (Disease Ontology:DOID:0110853); rhizomelic chondrodysplasia punctata (Disease Ontology:DOID:2580)", "pathway": " (rno:84114); (R-RNO-75896); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2340111;8399344", "class_list": "", "function": "Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" } ], "go_molecular_function": "GO:0008609 alkylglycerone-phosphate synthase activity;GO:0071949 FAD binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1M8-1", "uniprot_id": [ { "id": "BRNP2_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1M8", "type": "external" } ], "mass": 89139.0, "length": 783, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 2", "gene_name": "Brinp2", "organism": "Rat", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 2 precursor", "refseq_ac": [ { "id": "NP_775138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775138", "type": "external" } ], "gene_names_uniprotkb": "Brinp2; Fam5b", "gene_names_refseq": "Brinp2; Fam5b", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 2", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 2 precursor; BMP/retinoic acid-inducible neural-specific protein 2; bone morphogenetic protein/retinoic acid inducible neural-specific 2; bone morphogenic protein/retinoic acid inducible neural-specific 2; family with sequence similarity 5, member B; protein FAM5B", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866)", "pathway": " (rno:286895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15193423;38843836", "class_list": "", "function": "Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition., [UniProtKB]; Results describe BRINP1, 2, and 3 genes, which have distinct regulatory mechanisms of expression within the nervous system and which suppress the cell cycle progression in nonneuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0035264 multicellular organism growth;GO:0045930 negative regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K1M8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62930-1", "uniprot_id": [ { "id": "CO9_RAT", "url": "https://www.uniprot.org/uniprot/Q62930", "type": "external" } ], "mass": 62281.0, "length": 554, "protein_name": "Complement component C9", "gene_name": "C9", "organism": "Rat", "refseq_name": "complement component C9 precursor", "refseq_ac": [ { "id": "NP_476487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476487", "type": "external" } ], "gene_names_uniprotkb": "C9", "gene_names_refseq": "C9", "protein_names_uniprotkb": "Complement component C9", "protein_names_refseq": "complement component 9; complement component C9 precursor; complement component C9", "tax_id": 10116, "disease": "complement component 9 deficiency (Disease Ontology:DOID:0060303); polycystic kidney disease (Disease Ontology:DOID:0080322); age related macular degeneration 15 (Disease Ontology:DOID:0110027); opiate dependence (Disease Ontology:DOID:2559); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:117512); (R-RNO-977606)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11870622;18178252;21454685;9212048", "class_list": "", "function": "Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:9212048). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (By similarity). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (By similarity). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; The membrane attack complex of complement induces caspase activation and apoptosis., [RefSeq, PubMed]; The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62957", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0055085 transmembrane transport;GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62930-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5M5-1", "uniprot_id": [ { "id": "ACMSD_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5M5", "type": "external" } ], "mass": 38091.0, "length": 336, "protein_name": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase", "gene_name": "Acmsd", "organism": "Rat", "refseq_name": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase", "refseq_ac": [ { "id": "NP_599199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599199", "type": "external" } ], "gene_names_uniprotkb": "Acmsd", "gene_names_refseq": "Acmsd", "protein_names_uniprotkb": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; 4.1.1.45; Picolinate carboxylase", "protein_names_refseq": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase", "tax_id": 10116, "disease": "kidney failure (Disease Ontology:DOID:1074)", "pathway": " (rno:171385)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11802786;12140278;25289390", "class_list": "", "function": "Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Results provide the first evidence that alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is associated with cholesterol metabolism, and ACMSD gene expression may be upregulated by sterol regulatory element-binding protein-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:1904985 negative regulation of quinolinate biosynthetic process;GO:0019748 secondary metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R5M5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925T8-1", "uniprot_id": [ { "id": "BRNP1_RAT", "url": "https://www.uniprot.org/uniprot/Q925T8", "type": "external" } ], "mass": 88654.0, "length": 760, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 1", "gene_name": "Brinp1", "organism": "Rat", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 1 precursor", "refseq_ac": [ { "id": "NP_536730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536730", "type": "external" } ], "gene_names_uniprotkb": "Brinp1; Brinp; Dbc1; Dbccr1; Fam5a", "gene_names_refseq": "Brinp1; Dbc1; Dbccr1", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 1; Deleted in bladder cancer protein 1 homolog", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 1 precursor; BMP/retinoic acid-inducible neural-specific protein 1; bone morphogenetic protein/retinoic acid inducible neural-specific 1; bone morphogenic protein/retinoic acid inducible neural-specific 1; deleted in bladder cancer 1; deleted in bladder cancer chromosome region candidate 1; deleted in bladder cancer protein 1 homolog", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:140610)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15193423;22161971;38843836", "class_list": "", "function": "Plays a role in neurogenesis and brain development. May suppress cell cycle progression in postmitotic neurons by inhibiting G1/S transition., [UniProtKB, UniProtKB]; The findings of this study identify a role for RLR signaling and type I IFN in regulating astrocyte innate immune responses after SCI. (c) 2011 Wiley Periodicals, Inc., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0008283 cell population proliferation;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0007614 short-term memory;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q925T8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R193-1", "uniprot_id": [ { "id": "AT1B4_RAT", "url": "https://www.uniprot.org/uniprot/Q9R193", "type": "external" } ], "mass": 41518.0, "length": 356, "protein_name": "Protein ATP1B4", "gene_name": "Atp1b4", "organism": "Rat", "refseq_name": "protein ATP1B4 isoform 2", "refseq_ac": [ { "id": "NP_445833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445833", "type": "external" } ], "gene_names_uniprotkb": "Atp1b4", "gene_names_refseq": "Ac2-628; Atp1b4", "protein_names_uniprotkb": "Protein ATP1B4; X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m", "protein_names_refseq": "ATPase, (Na+)/K+ transporting, beta 4 polypeptide; protein ATP1B4 isoform 2; protein ATP1B4; x,K-ATPase subunit beta-m; x/potassium-transporting ATPase subunit beta-m", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:84396); (R-RNO-2173795)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10456317;14656723;17592128", "class_list": "", "function": "Eutherian Atp1b4 has lost its ancestral function as a Na,K-ATPase beta-subunit and associates with transcriptional coregulator Ski-interacting protein (SKIP)., [RefSeq, PubMed]; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R192", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0000785 chromatin;GO:0005637 nuclear inner membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R193-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64591-1", "uniprot_id": [ { "id": "DECR_RAT", "url": "https://www.uniprot.org/uniprot/Q64591", "type": "external" } ], "mass": 36133.0, "length": 335, "protein_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial", "gene_name": "Decr1", "organism": "Rat", "refseq_name": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor", "refseq_ac": [ { "id": "NP_476545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476545", "type": "external" } ], "gene_names_uniprotkb": "Decr1; Decr", "gene_names_refseq": "Decr1", "protein_names_uniprotkb": "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 1.3.1.124; 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]", "protein_names_refseq": "2,4-dienoyl CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase", "tax_id": 10116, "disease": "", "pathway": " (rno:117543); (R-RNO-77288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17636013;23486364;2383590", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the Enoyl-CoA delta isomerase 1 (ECI1) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Acts primarily on polyunsaturated fatty acids. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally., [UniProtKB, UniProtKB]; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA., [UniProtKB, UniProtKB]; Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats., [RefSeq, PubMed]; Elevated expression of Decr1 impairs ErbB2/Neu-induced mammary tumor development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCV4", "ec_number_list": [ { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" } ], "go_molecular_function": "GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0070402 NADPH binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:1902494 catalytic complex", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64591-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63100-1", "uniprot_id": [ { "id": "DC1I1_RAT", "url": "https://www.uniprot.org/uniprot/Q63100", "type": "external" } ], "mass": 72754.0, "length": 643, "protein_name": "Cytoplasmic dynein 1 intermediate chain 1", "gene_name": "Dync1i1", "organism": "Rat", "refseq_name": "cytoplasmic dynein 1 intermediate chain 1 isoform 1", "refseq_ac": [ { "id": "NP_062107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062107", "type": "external" } ], "gene_names_uniprotkb": "Dync1i1; Dnci1; Dncic1", "gene_names_refseq": "Dnci1; Dncic1; Dync1i1; IC74-1A; IC74-1B", "protein_names_uniprotkb": "Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; DH IC-1; Dynein intermediate chain 1, cytosolic", "protein_names_refseq": "DH IC-1; cytoplasmic dynein 1 intermediate chain 1 isoform 1; cytoplasmic dynein 1 intermediate chain 1; cytoplasmic dynein intermediate chain 1; dynein cytoplasmic 1 intermediate chain 1A; dynein cytoplasmic 1 intermediate chain 1B; dynein cytoplasmic 1 intermediate chain 1C; dynein cytoplasmic 1 intermediate chain 1D; dynein intermediate chain 1, cytosolic; dynein, cytoplasmic, intermediate chain 1", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:29564); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 13, "publication_count": 11, "publication_id_list": "1387402;14985359;15240697;17279546;17965411;22673903;23577064;7499404;8522607;8688562;9790665", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The dynein-dynactin interaction proceeds through a disorder-to-order transition Erratum:[PLoS One. 2024 Jun 4;19(6):e0304916. doi: 10.1371/journal.pone.0304916. PMID: 38833489], [RefSeq, PubMed]; The intermediate chain of dynein binds to kinesin light chains 1 and 2. The interaction is both direct and specific, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0003777 microtubule motor activity;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0043657 host cell", "go_biological_process": "GO:0075733 intracellular transport of virus;GO:0047496 vesicle transport along microtubule;GO:0010970 transport along microtubule;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63100-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3X0-1", "uniprot_id": [ { "id": "CASC3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3X0", "type": "external" } ], "mass": 75904.0, "length": 699, "protein_name": "Protein CASC3", "gene_name": "Casc3", "organism": "Rat", "refseq_name": "protein CASC3", "refseq_ac": [ { "id": "NP_671485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671485", "type": "external" } ], "gene_names_uniprotkb": "Casc3; Mln51", "gene_names_refseq": "Btz; Casc3; Mln51", "protein_names_uniprotkb": "Protein CASC3; Btz; Cancer susceptibility candidate gene 3 protein homolog; Metastatic lymph node gene 51 protein homolog; Protein barentsz", "protein_names_refseq": "barentsz protein; cancer susceptibility 3; cancer susceptibility candidate 3; cancer susceptibility candidate gene 3 protein homolog; metastatic lymph node 51; metastatic lymph node gene 51 protein homolog; protein CASC3; protein barentsz", "tax_id": 10116, "disease": "", "pathway": " (rno:259170); (R-RNO-159236); (R-RNO-72163); (R-RNO-975957)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12843282;22673903", "class_list": "", "function": "Data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic ribonucleoprotein particles in hippocampal neurons, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer (By similarity). Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0008298 intracellular mRNA localization;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K3X0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS7-1", "uniprot_id": [ { "id": "CC174_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS7", "type": "external" } ], "mass": 54449.0, "length": 474, "protein_name": "Coiled-coil domain-containing protein 174", "gene_name": "Ccdc174", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 174", "refseq_ac": [ { "id": "NP_001009659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009659", "type": "external" } ], "gene_names_uniprotkb": "Ccdc174", "gene_names_refseq": "Ccdc174; RGD1305225", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 174", "protein_names_refseq": "coiled-coil domain-containing protein 174; uncharacterized protein C3orf19 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:297458)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in neuronal development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQS7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXU8-1", "uniprot_id": [ { "id": "DC1L1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXU8", "type": "external" } ], "mass": 56792.0, "length": 523, "protein_name": "Cytoplasmic dynein 1 light intermediate chain 1", "gene_name": "Dync1li1", "organism": "Rat", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 1 isoform 1", "refseq_ac": [ { "id": "NP_665715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665715", "type": "external" } ], "gene_names_uniprotkb": "Dync1li1; Dncli1", "gene_names_refseq": "Dncli1; Dnclic1; Dync1li1; LIC1", "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 1; DLC-A; Dynein light chain A; Dynein light intermediate chain 1, cytosolic", "protein_names_refseq": "DLC-A; cytoplasmic dynein 1 light intermediate chain 1 isoform 1; cytoplasmic dynein 1 light intermediate chain 1-like; cytoplasmic dynein 1 light intermediate chain 1; dynein light chain A; dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1; dynein, cytoplasmic, light intermediate polypeptide 1", "tax_id": 10116, "disease": "", "pathway": " (rno:252902); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-5663220); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "10545494;10893222;10893223;22673903;24778311;30674581", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LIC1, through BicD2, is required for apical nuclear migration in neural progenitors. In newborn neurons, we observe specific roles for LIC1 in the multipolar to bipolar transition and glial-guided neuronal migration. In contrast, LIC2 contributes to a novel dynein role in the little-studied mode of migration, terminal somal translocation., [RefSeq, PubMed]; PKA-mediated LIC1 phosphorylation causes only partial lyso/LE dispersal, suggesting a role for additional, parallel mechanisms for dynein recruitment to lyso/LEs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0030666 endocytic vesicle membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0051301 cell division;GO:1990090 cellular response to nerve growth factor stimulus;GO:0060627 regulation of vesicle-mediated transport;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QXU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XT5-1", "uniprot_id": [ { "id": "BCDO1_RAT", "url": "https://www.uniprot.org/uniprot/Q91XT5", "type": "external" } ], "mass": 63637.0, "length": 566, "protein_name": "Beta,beta-carotene 15,15'-dioxygenase", "gene_name": "Bco1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bco1; Bcdo1; Bcdo; Bcmo1", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta,beta-carotene 15,15'-dioxygenase; 1.13.11.63; Beta-carotene dioxygenase 1; Beta-carotene oxygenase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114106); (R-RNO-975634)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.63", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.63", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0042574 retinal metabolic process;GO:1901810 beta-carotene metabolic process;GO:0016121 carotene catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91XT5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESR9-1", "uniprot_id": [ { "id": "ABCA2_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESR9", "type": "external" } ], "mass": 270928.0, "length": 2434, "protein_name": "ATP-binding cassette sub-family A member 2", "gene_name": "Abca2", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family A member 2", "refseq_ac": [ { "id": "NP_077372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077372", "type": "external" } ], "gene_names_uniprotkb": "Abca2; Abc2", "gene_names_refseq": "Abc2; Abca2", "protein_names_uniprotkb": "ATP-binding cassette sub-family A member 2; 7.6.2.-; ATP-binding cassette 2; ATP-binding cassette transporter 2", "protein_names_refseq": "ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A (ABC1), member 2; ATP-binding cassette, subfamily A (ABC1), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:79248); (R-RNO-1369062)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10970803;11157071;12210128;17240058;22086926;22673903;24090084;24201375;38843836", "class_list": "", "function": "ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination., [RefSeq, PubMed]; Control of ABCA2 expression level may be a key locus of regulation for esterification of plasma membrane-derived cholesterol through modulation of sphingolipid metabolism., [RefSeq, PubMed]; Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization., [RefSeq, PubMed]; Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (By similarity). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926). May play a role in myelin formation (PubMed:12210128)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. May play a role in myelination, perhaps as a transporter for certain kinds of myelin chemical components (PubMed:12210128). May play an important role in gamma-secretase processing of APP and thus in amyloid-beta peptide generation (PubMed:22086926). Regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism (PubMed:24201375)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 25, "predicted_n_glycosites": 24, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 26, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0099038 ceramide floppase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0006869 lipid transport;GO:0007626 locomotory behavior;GO:0055085 transmembrane transport;GO:1902004 positive regulation of amyloid-beta formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ESR9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63064-1", "uniprot_id": [ { "id": "CD52_RAT", "url": "https://www.uniprot.org/uniprot/Q63064", "type": "external" } ], "mass": 9829.0, "length": 96, "protein_name": "CAMPATH-1 antigen", "gene_name": "Cd52", "organism": "Rat", "refseq_name": "CAMPATH-1 antigen precursor", "refseq_ac": [ { "id": "NP_446435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446435", "type": "external" } ], "gene_names_uniprotkb": "Cd52; Cdw52; Rb7", "gene_names_refseq": "B7; Cd52", "protein_names_uniprotkb": "CAMPATH-1 antigen; Lymphocyte differentiation antigen B7", "protein_names_refseq": "CAMPATH-1 antigen precursor; CAMPATH-1 antigen; CD52 antigen; lymphocyte differentiation antigen B7", "tax_id": 10116, "disease": "", "pathway": " (rno:117054); (R-RNO-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19238728;7515288", "class_list": "", "function": "CD52+ cells were found in areas active in vasculogenesis at early embryo stages and in the walls of the vessels in the liver at mid gestation., [RefSeq, PubMed]; May play a role in carrying and orienting carbohydrate, as well as having a more specific role., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097225 sperm midpiece;GO:0098552 side of membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63064-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64359-1", "uniprot_id": [ { "id": "CNGA4_RAT", "url": "https://www.uniprot.org/uniprot/Q64359", "type": "external" } ], "mass": 65675.0, "length": 575, "protein_name": "Cyclic nucleotide-gated channel alpha-4", "gene_name": "Cnga4", "organism": "Rat", "refseq_name": "cyclic nucleotide-gated channel alpha-4", "refseq_ac": [ { "id": "NP_445948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445948", "type": "external" } ], "gene_names_uniprotkb": "Cnga4; Cgn2", "gene_names_refseq": "CNG-4; CNG4; CNG5; Cgn2; Cnga4; OCNC2; rOCNC2", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNGa4; OCNC2; Olfactory cyclic nucleotide-gated channel subunit 2", "protein_names_refseq": "CNCalpha4 C; CNG channel alpha-4; cyclic nucleotide gated cation channel; cyclic nucleotide gated channel alpha 4; cyclic nucleotide-gated cation channel alpha-4; cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated olfactory channel subunit OCNC2; olfactory cyclic nucleotide-gated channel subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:85258); (R-RNO-5620916)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10377344;11764791;15134638;15195096;22786723;27405959;7522325;7522482;9208862;9878057", "class_list": "", "function": "CGMP activated olfactory CNG channels by binding to the two CNGA2 subunits and the CNGA4 subunit. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations (PubMed:10377344, PubMed:15134638, PubMed:27405959, PubMed:7522325, PubMed:7522482, PubMed:9878057). May conduct nitric oxide-gated Ca(2+) currents relevant to neurons of vomeronasal organ, a system involved in the perception of pheromones (PubMed:9208862)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6Q2I4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006813 potassium ion transport;GO:0007608 sensory perception of smell;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64359-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0W7-1", "uniprot_id": [ { "id": "CLIC4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0W7", "type": "external" } ], "mass": 28633.0, "length": 253, "protein_name": "Chloride intracellular channel protein 4", "gene_name": "Clic4", "organism": "Rat", "refseq_name": "chloride intracellular channel protein 4", "refseq_ac": [ { "id": "NP_114006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114006", "type": "external" } ], "gene_names_uniprotkb": "Clic4", "gene_names_refseq": "Clic4", "protein_names_uniprotkb": "Chloride intracellular channel protein 4; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC4; Intracellular chloride ion channel protein p64H1", "protein_names_refseq": "chloride intracellular channel 4 (mitochondrial); chloride intracellular channel protein 4; glutaredoxin-like oxidoreductase CLIC4; intracellular chloride ion channel protein p64H1; mitochondrial chloride intracellular channel 4", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:83718)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17453412;18302930;20610659;22673903;24503951;26777142;29131056;29518790;9295337", "class_list": "", "function": "CLIC4 plays an important role in retinal pigment epithelium-photoreceptor adhesion, perhaps by modulating the activity of cell surface channels/transporters., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (PubMed:17453412, PubMed:9295337). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension., [RefSeq, PubMed]; Overexpression of CLIC4 suggests that alterations in the proximal tubular compartment during hypertension should be further examined and that CLIC4 may be a useful early marker of renal tubular alterations due to elevated blood pressure, [RefSeq, PubMed]; The authors report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria., [RefSeq, PubMed]; Xenon decreased neuronal apoptosis via Bcl-2- and CLIC4-mediated pathways in white matter damage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0009566 fertilization;GO:0030336 negative regulation of cell migration;GO:0030216 keratinocyte differentiation;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0W7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHS6-1", "uniprot_id": [ { "id": "ASIC4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHS6", "type": "external" } ], "mass": 59325.0, "length": 539, "protein_name": "Acid-sensing ion channel 4", "gene_name": "Asic4", "organism": "Rat", "refseq_name": "acid-sensing ion channel 4", "refseq_ac": [ { "id": "NP_071570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071570", "type": "external" } ], "gene_names_uniprotkb": "Asic4; Accn4; Spasic", "gene_names_refseq": "Accn4; Asic4; Spasic", "protein_names_uniprotkb": "Acid-sensing ion channel 4; ASIC4; Amiloride-sensitive cation channel 4; Spinal cord ASIC", "protein_names_refseq": "acid sensing ion channel 4; acid-sensing (proton-gated) ion channel family member 4; acid-sensing ion channel 4; amiloride-sensitive cation channel 4, pituitary; putative acid-sensing ion channel; spinal chord ASIC; spinal cord ASIC", "tax_id": 10116, "disease": "", "pathway": " (rno:63882); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1039/D0MO00044B;10852210;10923674;16085050;34106099", "class_list": "", "function": "Acid-sensing ion channel currents are susceptible to regulation by redox agents. (Acid-sensing ion channels), [RefSeq, PubMed]; Does not exhibit measurable stand-alone pH-gated sodium channel activity but may form pH-gated heterotrimeric sodium channels. Its activity could also depend on alternative gating mechanisms., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYV9", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0001662 behavioral fear response;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHS6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63690-1", "uniprot_id": [ { "id": "BAX_RAT", "url": "https://www.uniprot.org/uniprot/Q63690", "type": "external" } ], "mass": 21351.0, "length": 192, "protein_name": "Apoptosis regulator BAX", "gene_name": "Bax", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bax", "gene_names_refseq": "", "protein_names_uniprotkb": "Apoptosis regulator BAX", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); rheumatic heart disease (Disease Ontology:DOID:0050827); pre-malignant neoplasm (Disease Ontology:DOID:0060071); brain glioma (Disease Ontology:DOID:0060108); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); leiomyoma (Disease Ontology:DOID:127); ataxia telangiectasia (Disease Ontology:DOID:12704); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); dementia (Disease Ontology:DOID:1307); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); morphine dependence (Disease Ontology:DOID:2560); endometriosis (Disease Ontology:DOID:289); acute kidney failure (Disease Ontology:DOID:3021); teratoma (Disease Ontology:DOID:3307); middle cerebral artery infarction (Disease Ontology:DOID:3525); intermittent claudication (Disease Ontology:DOID:3669); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myopathy (Disease Ontology:DOID:423); macular degeneration (Disease Ontology:DOID:4448); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); intestinal disease (Disease Ontology:DOID:5295); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial myopathy (Disease Ontology:DOID:699); thyroiditis (Disease Ontology:DOID:7166); osteoarthritis (Disease Ontology:DOID:8398); retinal degeneration (Disease Ontology:DOID:8466); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); toxoplasmosis (Disease Ontology:DOID:9965)", "pathway": " (rno:24887); (R-RNO-111457); (R-RNO-111458); (R-RNO-111461); (R-RNO-111463); (R-RNO-111469); (R-RNO-114294); (R-RNO-5620971); (R-RNO-6804114)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "15383280;7828536;8600029;8994223", "class_list": "", "function": "Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62995;Q64383", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0007283 spermatogenesis;GO:0007399 nervous system development;GO:0008283 cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63690-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XU8-1", "uniprot_id": [ { "id": "CDS2_RAT", "url": "https://www.uniprot.org/uniprot/Q91XU8", "type": "external" } ], "mass": 51323.0, "length": 443, "protein_name": "Phosphatidate cytidylyltransferase 2", "gene_name": "Cds2", "organism": "Rat", "refseq_name": "phosphatidate cytidylyltransferase 2", "refseq_ac": [ { "id": "NP_446095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446095", "type": "external" } ], "gene_names_uniprotkb": "Cds2", "gene_names_refseq": "Cds2", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase 2; 2.7.7.41; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2", "protein_names_refseq": "CDP-DAG synthase 2; CDP-DG synthase 2; CDP-DG synthetase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2; phosphatidate cytidylyltransferase 2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:114101); (R-RNO-1483148)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29253589", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:29253589). Exhibits specificity for the nature of the acyl chains at the sn-1 and sn-2 positions in the substrate, PA and the preferred acyl chain composition is 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid (By similarity). Plays an important role in regulating the growth and maturation of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91XU8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true } ]