[ { "uniprot_canonical_ac": "A0ABZ3NNP9-1", "uniprot_id": [ { "id": "A0ABZ3NNP9_RAT", "url": "https://www.uniprot.org/uniprot/A0ABZ3NNP9", "type": "external" } ], "mass": 97032.0, "length": 862, "protein_name": "Leucine-zipper-like transcriptional regulator 1", "gene_name": "Lztr1", "organism": "Rat", "refseq_name": "leucine-zipper-like transcriptional regulator 1 isoform X1", "refseq_ac": [ { "id": "XP_006248769", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006248769", "type": "external" } ], "gene_names_uniprotkb": "Lztr1", "gene_names_refseq": "Lztr1", "protein_names_uniprotkb": "Leucine-zipper-like transcriptional regulator 1", "protein_names_refseq": "leucine-zipper-like transcriptional regulator 1 isoform X1", "tax_id": 10116, "disease": "Noonan syndrome 2 (Disease Ontology:DOID:0060580); Noonan syndrome 10 (Disease Ontology:DOID:0060588); schwannomatosis 2 (Disease Ontology:DOID:0070481); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068); neurilemmoma (Disease Ontology:DOID:3192); schwannomatosis (Disease Ontology:DOID:3204); Noonan syndrome (Disease Ontology:DOID:3490); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:360745)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0055038 recycling endosome membrane;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0ABZ3NNP9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0ABK0M8C9-1", "uniprot_id": [ { "id": "A0ABK0M8C9_RAT", "url": "https://www.uniprot.org/uniprot/A0ABK0M8C9", "type": "external" } ], "mass": 18911.0, "length": 166, "protein_name": "Trafficking protein particle complex subunit", "gene_name": "Trappc2l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trappc2l", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking protein particle complex subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0030008 TRAPP complex;GO:0005829 cytosol", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0ABK0M8C9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0ABZ3NN98-1", "uniprot_id": [ { "id": "A0ABZ3NN98_RAT", "url": "https://www.uniprot.org/uniprot/A0ABZ3NN98", "type": "external" } ], "mass": 43884.0, "length": 389, "protein_name": "Double C2-like domain-containing protein", "gene_name": "Doc2g", "organism": "Rat", "refseq_name": "double C2-like domain-containing protein gamma isoform X1", "refseq_ac": [ { "id": "XP_006230797", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230797", "type": "external" } ], "gene_names_uniprotkb": "Doc2g; Doc2gp", "gene_names_refseq": "Doc2gp; Doc2g", "protein_names_uniprotkb": "Double C2-like domain-containing protein", "protein_names_refseq": "double C2-like domain-containing protein gamma isoform X1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:293654)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0098793 presynapse", "go_biological_process": "GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0ABZ3NN98-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0ABK0M9J5-1", "uniprot_id": [ { "id": "A0ABK0M9J5_RAT", "url": "https://www.uniprot.org/uniprot/A0ABK0M9J5", "type": "external" } ], "mass": 58815.0, "length": 523, "protein_name": "RAR-related orphan receptor A", "gene_name": "Rora", "organism": "Rat", "refseq_name": "nuclear receptor ROR-alpha isoform 1", "refseq_ac": [ { "id": "NP_001414296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414296", "type": "external" } ], "gene_names_uniprotkb": "Rora", "gene_names_refseq": "Rora", "protein_names_uniprotkb": "RAR-related orphan receptor A", "protein_names_refseq": "RAR-related orphan receptor alpha; nuclear receptor ROR-alpha isoform 1; nuclear receptor ROR-alpha-like; nuclear receptor ROR-alpha", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); childhood-onset asthma (Disease Ontology:DOID:0080815); nocturnal asthma (Disease Ontology:DOID:0080826); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481); myocardial infarction (Disease Ontology:DOID:5844); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0008142 oxysterol binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0ABK0M9J5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0ABK0M8H4-1", "uniprot_id": [ { "id": "A0ABK0M8H4_RAT", "url": "https://www.uniprot.org/uniprot/A0ABK0M8H4", "type": "external" } ], "mass": 96596.0, "length": 852, "protein_name": "Nitric oxide synthase, inducible", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Nitric oxide synthase, inducible; 1.14.13.39; Inducible NO synthase; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0ABK0M8H4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0ABK0M8N4-1", "uniprot_id": [ { "id": "A0ABK0M8N4_RAT", "url": "https://www.uniprot.org/uniprot/A0ABK0M8N4", "type": "external" } ], "mass": 131128.0, "length": 1201, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Hipk2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hipk2", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" 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0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045202 synapse", "go_biological_process": "GO:0071344 diphosphate metabolic process;GO:0051881 regulation of mitochondrial membrane potential;GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AK43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZVP7-1", "uniprot_id": [ { "id": "A0A8I5ZVP7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVP7", "type": "external" } ], "mass": 23232.0, "length": 205, "protein_name": "Golgi apparatus membrane protein TVP23 homolog", "gene_name": "Tvp23b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tvp23b; Fam18b2", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi apparatus membrane protein TVP23 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:687358)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8I5ZVP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48450-1", "uniprot_id": [ { "id": "LSS_RAT", "url": "https://www.uniprot.org/uniprot/P48450", "type": "external" } ], "mass": 83301.0, "length": 733, "protein_name": "Lanosterol synthase", "gene_name": "Lss; Spatc1l", "organism": "Rat", "refseq_name": "lanosterol synthase", "refseq_ac": [ { "id": "NP_112311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112311", "type": "external" } ], "gene_names_uniprotkb": "Lss; Spatc1l; Lss; Osc; Spatc1l", "gene_names_refseq": "Lss", "protein_names_uniprotkb": "Lanosterol synthase; 2,3-epoxysqualene--lanosterol cyclase; 5.4.99.7; OSC; Oxidosqualene--lanosterol cyclase", "protein_names_refseq": "2,3-epoxysqualene--lanosterol cyclase; 2,3-oxidosqualene: lanosterol cyclase; OSC; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); lanosterol synthase; oxidosqualene--lanosterol cyclase", "tax_id": 10116, "disease": "hypotrichosis 14 (Disease Ontology:DOID:0080582); alopecia-mental retardation syndrome 4 (Disease Ontology:DOID:0080950); cataract 44 (Disease Ontology:DOID:0110267); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:499418); (rno:81681); (R-RNO-9969896)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16440058;38079167;7568116;7735243", "class_list": "", "function": "Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:7568116). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis Via Regulating SREBP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62811", "ec_number_list": [ { "id": "5.4.99.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.7", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0000250 lanosterol synthase activity;GO:0042802 identical protein binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0031647 regulation of protein stability;GO:0016125 sterol metabolic process;GO:0006694 steroid biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48450-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE24-1", "uniprot_id": [ { "id": "UBP54_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE24", "type": "external" } ], "mass": 176155.0, "length": 1588, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 54", "gene_name": "Usp54", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 54", "refseq_ac": [ { "id": "NP_001008863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008863", "type": "external" } ], "gene_names_uniprotkb": "Usp54", "gene_names_refseq": "Usp54", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 54; 3.4.19.12; Ubiquitin-specific peptidase 54", "protein_names_refseq": "inactive ubiquitin carboxyl-terminal hydrolase 54; inactive ubiquitin-specific peptidase 54; ubiquitin carboxyl-terminal hydrolase 54; ubiquitin specific protease 54", "tax_id": 10116, "disease": "", "pathway": " (rno:408223)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060002;22673903", "class_list": "", "function": "Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins. Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains. Not able to deubiquitinate substrates with shorter ubiquitin chains. Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQU8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IE24-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LW30-1", "uniprot_id": [ { "id": "UNC5D_RAT", "url": "https://www.uniprot.org/uniprot/F1LW30", "type": "external" } ], "mass": 106520.0, "length": 956, "protein_name": "Netrin receptor UNC5D", "gene_name": "Unc5d", "organism": "Rat", "refseq_name": "netrin receptor UNC5D precursor", "refseq_ac": [ { "id": "NP_001100789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100789", "type": "external" } ], "gene_names_uniprotkb": "Unc5d", "gene_names_refseq": "Unc5d", "protein_names_uniprotkb": "Netrin receptor UNC5D; Protein unc-5 homolog D", "protein_names_refseq": "netrin receptor UNC5D precursor; netrin receptor UNC5D; protein unc-5 homolog D; unc-5 homolog D", "tax_id": 10116, "disease": "", "pathway": " (rno:306534)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25374360", "class_list": "", "function": "Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 2, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 2, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 2, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006915 apoptotic process;GO:0098609 cell-cell adhesion;GO:0007411 axon guidance;GO:2001222 regulation of neuron migration;GO:0021859 pyramidal neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1LW30-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.1010000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ59-1", "uniprot_id": [ { "id": "SH21A_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ59", "type": "external" } ], "mass": 13992.0, "length": 126, "protein_name": "SH2 domain-containing protein 1A", "gene_name": "Sh2d1a", "organism": "Rat", "refseq_name": "SH2 domain-containing protein 1A", "refseq_ac": [ { "id": "NP_001102783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102783", "type": "external" } ], "gene_names_uniprotkb": "Sh2d1a", "gene_names_refseq": "RGD1562408; Sh2d1a", "protein_names_uniprotkb": "SH2 domain-containing protein 1A", "protein_names_refseq": "SH2 domain protein 1A; SH2 domain-containing protein 1A", "tax_id": 10116, "disease": "X-linked lymphoproliferative syndrome 1 (Disease Ontology:DOID:0060705)", "pathway": " (rno:501502)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16223723;22673903", "class_list": "", "function": "Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3 (PubMed:16223723)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; SAP may serve as a negative regulator of Trk receptor activation and downstream signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0045087 innate immune response;GO:0006968 cellular defense response;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RZ59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21463-1", "uniprot_id": [ { "id": "TSHR_RAT", "url": "https://www.uniprot.org/uniprot/P21463", "type": "external" } ], "mass": 86475.0, "length": 764, "protein_name": "Thyrotropin receptor", "gene_name": "Tshr", "organism": "Rat", "refseq_name": "thyrotropin receptor precursor", "refseq_ac": [ { "id": "NP_037020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037020", "type": "external" } ], "gene_names_uniprotkb": "Tshr; TSHR", "gene_names_refseq": "TSHRA; Tshr", "protein_names_uniprotkb": "Thyrotropin receptor; TSH-R; Thyroid-stimulating hormone receptor", "protein_names_refseq": "TSH-R; thyrotropin receptor precursor; thyrotropin receptor", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); cardiomyopathy (Disease Ontology:DOID:0050700); congenital nongoitrous hypothyroidism 1 (Disease Ontology:DOID:0070126); nonautoimmune hyperthyroidism (Disease Ontology:DOID:0081101); familial gestational hyperthyroidism (Disease Ontology:DOID:0081102); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Graves' disease (Disease Ontology:DOID:12361); hyperthyroidism (Disease Ontology:DOID:7998); mitral valve prolapse (Disease Ontology:DOID:988)", "pathway": " (rno:25360); (R-RNO-375281)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12045258;1332945;1696008;27059392;31439949;33191870;36857434", "class_list": "", "function": "Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that functional thyroid-stimulating hormone receptor is present in the caudal brainstem and hypothalamic nuclei of relevance for feeding control as a possibly uncleaved holoreceptor, and highlights a hindbrain component to central thyroid-stimulating hormone inhibition of food intake., [RefSeq, PubMed]; Expression and Role of Thyrotropin Receptors in Proopiomelanocortin-Producing Pituitary Cells., [RefSeq, PubMed]; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:1696008). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (By similarity). Additionally, plays a central role in controlling thyroid cell metabolism (PubMed:12045258)., [UniProtKB, PubMed, PubMed, UniProtKB]; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). Additionally, plays a central role in controlling thyroid cell metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thyroid-stimulating hormone receptor signaling restores skeletal muscle stem cell regeneration in rats with muscular dystrophy., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004996 thyroid-stimulating hormone receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0044877 protein-containing complex binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0008344 adult locomotory behavior;GO:0040012 regulation of locomotion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P21463-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30082-1", "uniprot_id": [ { "id": "GLR_RAT", "url": "https://www.uniprot.org/uniprot/P30082", "type": "external" } ], "mass": 55038.0, "length": 485, "protein_name": "Glucagon receptor", "gene_name": "Gcgr", "organism": "Rat", "refseq_name": "glucagon receptor isoform a precursor", "refseq_ac": [ { "id": "NP_742088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742088", "type": "external" } ], "gene_names_uniprotkb": "Gcgr", "gene_names_refseq": "Gcgr", "protein_names_uniprotkb": "Glucagon receptor; GL-R", "protein_names_refseq": "GL-R; glucagon receptor isoform a precursor; glucagon receptor perhaps same as Niddm3", "tax_id": 10116, "disease": "Mahvash Disease (Disease Ontology:DOID:0112306); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24953); (R-RNO-163359); (R-RNO-416476); (R-RNO-420092)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "22673903;23918690;26975347;8082779;8384375;8384842", "class_list": "", "function": "G protein-coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed]; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB]; Significant higher GluR density (mRNA and proteins) following exercise and fasting than in the control group., [RefSeq, PubMed]; The vasodilatation due to glucagon evokes via the glucagon-receptor, but also via the receptor for GLP-1, and it is endothelium-independent., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30082-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHT6-1", "uniprot_id": [ { "id": "AS3MT_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHT6", "type": "external" } ], "mass": 41056.0, "length": 369, "protein_name": "Arsenite methyltransferase", "gene_name": "As3mt", "organism": "Rat", "refseq_name": "arsenite methyltransferase", "refseq_ac": [ { "id": "NP_543166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543166", "type": "external" } ], "gene_names_uniprotkb": "As3mt; Cyt19", "gene_names_refseq": "As3mt; Cyt19", "protein_names_uniprotkb": "Arsenite methyltransferase; 2.1.1.137; Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase", "protein_names_refseq": "S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; arsenite methyltransferase; methylarsonite methyltransferase; methyltransferase Cyt19", "tax_id": 10116, "disease": "", "pathway": " (rno:140925); (R-RNO-156581)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11790780;15606138;15808521;22673903", "class_list": "", "function": "Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH., [UniProtKB, PubMed]; Enzyme catalyzing the conversion of inorganic arsenic to volatile arsenicals., [RefSeq, PubMed]; In rat AS3MT, Cys156 located in a well-defined cavity structure may be situated to participate in the binding of substrates which contain A(III)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.137", "type": "external" } ], "go_molecular_function": "GO:0008276 protein methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0030791 arsenite methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0009404 toxin metabolic process;GO:0018872 arsonoacetate metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHT6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28647-1", "uniprot_id": [ { "id": "AA3R_RAT", "url": "https://www.uniprot.org/uniprot/P28647", "type": "external" } ], "mass": 36629.0, "length": 320, "protein_name": "Adenosine receptor A3", "gene_name": "Adora3", "organism": "Rat", "refseq_name": "adenosine receptor A3 isoform a", "refseq_ac": [ { "id": "NP_001289679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289679", "type": "external" } ], "gene_names_uniprotkb": "Adora3", "gene_names_refseq": "A3; Adora3; TGPCR1", "protein_names_uniprotkb": "Adenosine receptor A3; TGPCR1", "protein_names_refseq": "Adenosine receptor A3; adenosine receptor A3 isoform a; adenosine receptor A3-like; putative G-protein coupled receptor", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 116 (Disease Ontology:DOID:0112162)", "pathway": " (rno:100911796); (R-RNO-417973); (R-RNO-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10692494;11278110;1323836;16005018;1647979;31556103;32461578;33007835;33472058;35775127;8612733", "class_list": "", "function": "Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure. Publication Status: Online-Only, [RefSeq, PubMed]; Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling., [RefSeq, PubMed]; Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor., [RefSeq, PubMed]; G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:1323836). Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) (PubMed:33472058). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels (By similarity). Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (PubMed:16005018). In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (PubMed:11278110). In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (PubMed:33472058). Highly expressed in inflammatory cells such as neutrophils and mast cells, inhibits neutrophil degranulation and reduces superoxide production, thereby modulating inflammatory responses (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63792", "ec_number_list": [], "go_molecular_function": "GO:0001609 G protein-coupled adenosine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0045202 synapse;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0014061 regulation of norepinephrine secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28647-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZK93-1", "uniprot_id": [ { "id": "GSG1L_RAT", "url": "https://www.uniprot.org/uniprot/D3ZK93", "type": "external" } ], "mass": 35903.0, "length": 322, "protein_name": "Germ cell-specific gene 1-like protein", "gene_name": "Gsg1l", "organism": "Rat", "refseq_name": "germ cell-specific gene 1-like protein", "refseq_ac": [ { "id": "NP_001406591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406591", "type": "external" } ], "gene_names_uniprotkb": "Gsg1l", "gene_names_refseq": "Gsg1l; RGD1562278", "protein_names_uniprotkb": "Germ cell-specific gene 1-like protein; GSG1-like protein", "protein_names_refseq": "GSG1-like protein; germ cell-specific gene 1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:499263)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22632720;22673903;22813734;26932439;27707810", "class_list": "", "function": "As a component of the inner core of AMPAR complexes, modifies AMPA receptor (AMPAR) gating., [UniProtKB, PubMed]; The current work reveals that GSG1L regulates strength of AMPAR-mediated synaptic transmission but not the receptor kinetic properties in hippocampal dentate granule neurons., [RefSeq, PubMed]; The interactomes of native AMPA-Rs and KA-Rs were compared and identified an AMPA-R auxiliary subunit, GSG1L., [RefSeq, PubMed]; These data demonstrate that GSG1L represents a new class of auxiliary subunit with distinct functional properties for AMPA receptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0032279 asymmetric synapse;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0050808 synapse organization;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZK93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G075-1", "uniprot_id": [ { "id": "ILEUA_RAT", "url": "https://www.uniprot.org/uniprot/Q4G075", "type": "external" } ], "mass": 42727.0, "length": 379, "protein_name": "Leukocyte elastase inhibitor A", "gene_name": "Serpinb1a", "organism": "Rat", "refseq_name": "leukocyte elastase inhibitor A", "refseq_ac": [ { "id": "NP_001026812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026812", "type": "external" } ], "gene_names_uniprotkb": "Serpinb1a", "gene_names_refseq": "Serpinb1a; Serpinb1", "protein_names_uniprotkb": "Leukocyte elastase inhibitor A; Serine protease inhibitor EIA; Serpin B1a", "protein_names_refseq": "leukocyte elastase inhibitor A; serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a", "tax_id": 10116, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (rno:291091); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;35291946", "class_list": "", "function": "Regulates the activity of the neutrophil proteases., [UniProtKB]; SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006954 inflammatory response;GO:0019725 cellular homeostasis;GO:0030336 negative regulation of cell migration;GO:0032691 negative regulation of interleukin-1 beta production;GO:0010951 negative regulation of endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G075-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02770-1", "uniprot_id": [ { "id": "ALBU_RAT", "url": "https://www.uniprot.org/uniprot/P02770", "type": "external" } ], "mass": 68731.0, "length": 608, "protein_name": "Albumin", "gene_name": "Alb", "organism": "Rat", "refseq_name": "albumin precursor", "refseq_ac": [ { "id": "NP_599153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599153", "type": "external" } ], "gene_names_uniprotkb": "Alb", "gene_names_refseq": "Alb1; Albza; Alb", "protein_names_uniprotkb": "Albumin", "protein_names_refseq": "albumin precursor; serum albumin", "tax_id": 10116, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); Zollinger-Ellison syndrome (Disease Ontology:DOID:0050782); stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); pre-eclampsia (Disease Ontology:DOID:10591); esophageal varix (Disease Ontology:DOID:112); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); heart disease (Disease Ontology:DOID:114); familial hyperlipidemia (Disease Ontology:DOID:1168); protein-energy malnutrition (Disease Ontology:DOID:11801); nephrotic syndrome (Disease Ontology:DOID:1184); alcoholic hepatitis (Disease Ontology:DOID:12351); leukemia (Disease Ontology:DOID:1240); twin-to-twin transfusion syndrome (Disease Ontology:DOID:13576); cholestasis (Disease Ontology:DOID:13580); obstructive jaundice (Disease Ontology:DOID:13603); root caries (Disease Ontology:DOID:14089); Reye syndrome (Disease Ontology:DOID:14525); pancreatic cancer (Disease Ontology:DOID:1793); hyperthyroxinemia (Disease Ontology:DOID:2855); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); blood protein disease (Disease Ontology:DOID:620); gastric cardia adenocarcinoma (Disease Ontology:DOID:6271); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24186); (R-RNO-114608); (R-RNO-159418); (R-RNO-189451); (R-RNO-189483); (R-RNO-2168880); (R-RNO-381426); (R-RNO-8957275); (R-RNO-8964058); (R-RNO-9707564); (R-RNO-9749641); (R-RNO-9757110); (R-RNO-9793528)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "22673903;2437111;31691325;564345;7017712;7358734;80265;893447;956149", "class_list": "", "function": "Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Predictive value of ischaemia-modified albumin in spermatogenesis in an experimental testicular torsion model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11382;Q5U3X3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005504 fatty acid binding;GO:0008270 zinc ion binding;GO:0015643 toxic substance binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0005604 basement membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0031667 response to nutrient levels;GO:0042311 vasodilation;GO:0009267 cellular response to starvation;GO:0046689 response to mercury ion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02770-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09117-1", "uniprot_id": [ { "id": "ALDOC_RAT", "url": "https://www.uniprot.org/uniprot/P09117", "type": "external" } ], "mass": 39284.0, "length": 363, "protein_name": "Fructose-bisphosphate aldolase C", "gene_name": "Aldoc", "organism": "Rat", "refseq_name": "fructose-bisphosphate aldolase C", "refseq_ac": [ { "id": "NP_036629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036629", "type": "external" } ], "gene_names_uniprotkb": "Aldoc", "gene_names_refseq": "ALDCAA; Aldoc; F16dip7; RATALDCAA", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase C; 4.1.2.13; Brain-type aldolase", "protein_names_refseq": "aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; brain-type aldolase; fructose-bisphosphate aldolase C", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); autoimmune disease of the nervous system (Disease Ontology:DOID:438); borna disease (Disease Ontology:DOID:5154); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24191); (R-RNO-6798695); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "18683930;1993044;21280042;22420779;22673903;2831050;3830170;9443807", "class_list": "", "function": "Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]; Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls. Publication Status: Online-Only, [RefSeq, PubMed]; Dorsal column nuclei (DCN)-cerebellar axons project to multiple compartments with terminals clustered mainly in the conventional spinocerebellar region with a coarse topography, which relates to the cortical compartments defined by aldolase C., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q54AI4;Q63037", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding;GO:0004332 fructose-bisphosphate aldolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0001666 response to hypoxia;GO:0006094 gluconeogenesis;GO:0031100 animal organ regeneration;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09117-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15943-1", "uniprot_id": [ { "id": "APLP2_RAT", "url": "https://www.uniprot.org/uniprot/P15943", "type": "external" } ], "mass": 86883.0, "length": 765, "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "Aplp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aplp2; APPL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Amyloid beta precursor like protein 2; APLP-2; Amyloid beta (A4) precursor-like protein 2; Amyloid protein homolog; Amyloid-like protein 2; CDEBP; CDEI box-binding protein; Sperm membrane protein YWK-II", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:64312); (R-RNO-114608); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1690887;22673903;8086458", "class_list": "", "function": "May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005634 nucleus;GO:0009986 cell surface;GO:0016020 membrane;GO:0097444 spine apparatus", "go_biological_process": "GO:0001967 suckling behavior;GO:0006878 intracellular copper ion homeostasis;GO:0007409 axonogenesis;GO:0007617 mating behavior;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15337-2", "uniprot_id": [ { "id": "CREB1_RAT", "url": "https://www.uniprot.org/uniprot/P15337", "type": "external" } ], "mass": 35081.0, "length": 327, "protein_name": "Cyclic AMP-responsive element-binding protein 1", "gene_name": "Creb1", "organism": "Rat", "refseq_name": "cyclic AMP-responsive element-binding protein 1 isoform B", "refseq_ac": [ { "id": "NP_112279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112279", "type": "external" } ], "gene_names_uniprotkb": "Creb1; Creb-1", "gene_names_refseq": "Creb1; Creb", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1", "protein_names_refseq": "CREB-1; Y protein; cAMP response element binding protein 1; cyclic AMP-responsive element-binding protein 1 isoform B; cyclic AMP-responsive element-binding protein 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); substance dependence (Disease Ontology:DOID:9973); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:81646); (R-RNO-198693); (R-RNO-199920); (R-RNO-375165); (R-RNO-442742); (R-RNO-881907); (R-RNO-9031628); (R-RNO-9634638)", "pathway_count": 8, "publication_count": 24, "publication_id_list": "10222196;11796524;12162494;12769553;1646483;17692820;17696880;1831258;20657584;22267118;22673903;24722832;2521922;30566056;36642184;37891366;38552745;38679120;38838971;38929606;7603449;7612187;7958915;8621702", "class_list": "", "function": "CBP Expression Contributes to Neuropathic Pain via CREB and MeCP2 Regulation in the Spared Nerve Injury Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-kappaB Signaling., [RefSeq, PubMed]; Divergent effects of chronic continuous and intermittent social defeat stress on emotional behaviors: Impact on phosphorylated CREB and BDNF protein levels in the rat hippocampus., [RefSeq, PubMed]; Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB expression in adult female rats., [RefSeq, PubMed]; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters (By similarity). Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation (By similarity). Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (By similarity). Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling (PubMed:30566056)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005759 mitochondrial matrix;GO:0030424 axon;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1990910 response to hypobaric hypoxia;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P15337-2", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50503-1", "uniprot_id": [ { "id": "F10A1_RAT", "url": "https://www.uniprot.org/uniprot/P50503", "type": "external" } ], "mass": 41280.0, "length": 368, "protein_name": "Hsc70-interacting protein", "gene_name": "Slc25a17; St13", "organism": "Rat", "refseq_name": "hsc70-interacting protein", "refseq_ac": [ { "id": "NP_112384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112384", "type": "external" } ], "gene_names_uniprotkb": "Slc25a17; St13; Fam10a1; Hip; Slc25a17", "gene_names_refseq": "St13", "protein_names_uniprotkb": "Hsc70-interacting protein; Hip; Protein FAM10A1; Protein ST13 homolog", "protein_names_refseq": "hip; hsc70-interacting protein; protein ST13 homolog; suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:81800); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22673903;23812373;29393594;7585962", "class_list": "", "function": "One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism., [UniProtKB, UniProtKB]; The tetratricopeptide repeat domain of rat Hip with the Hsp70 ATPase domain through an extensive interface, to form a bracket that locks ADP in the binding cleft., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0032564 dATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903334 positive regulation of protein folding;GO:0009617 response to bacterium;GO:0006457 protein folding;GO:0061084 negative regulation of protein refolding;GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50503-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G005-1", "uniprot_id": [ { "id": "ERCC3_RAT", "url": "https://www.uniprot.org/uniprot/Q4G005", "type": "external" } ], "mass": 89099.0, "length": 782, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB", "gene_name": "Ercc3", "organism": "Rat", "refseq_name": "general transcription and DNA repair factor IIH helicase/translocase subunit XPB", "refseq_ac": [ { "id": "NP_001026814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026814", "type": "external" } ], "gene_names_uniprotkb": "Ercc3", "gene_names_refseq": "Ercc3", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB; 5.6.2.4; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH subunit XPB", "protein_names_refseq": "DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; general transcription and DNA repair factor IIH helicase subunit XPB; general transcription and DNA repair factor IIH helicase/translocase subunit XPB", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group B (Disease Ontology:DOID:0110850); trichothiodystrophy (Disease Ontology:DOID:0111866); photosensitive trichothiodystrophy 2 (Disease Ontology:DOID:0111869); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); Down syndrome (Disease Ontology:DOID:14250); Cockayne syndrome (Disease Ontology:DOID:2962); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:291703); (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075)", "pathway_count": 20, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting and twisting that allows XPD/ERCC2 helicase to anchor. The ATP-dependent helicase activity of XPB/ERCC3 may be required for promoter escape. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G005-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC2-1", "uniprot_id": [ { "id": "ECSIT_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC2", "type": "external" } ], "mass": 49620.0, "length": 434, "protein_name": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "gene_name": "Ecsit", "organism": "Rat", "refseq_name": "evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001006987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006987", "type": "external" } ], "gene_names_uniprotkb": "Ecsit", "gene_names_refseq": "Ecsit", "protein_names_uniprotkb": "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "protein_names_refseq": "ECSIT homolog; ECSIT signalling integrator; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:300447); (R-RNO-166058); (R-RNO-6799198); (R-RNO-975138); (R-RNO-975871)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22982022;38843836", "class_list": "", "function": "Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; As part of the MCIA complex, involved in the assembly of the mitochondrial complex I., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0004857 enzyme inhibitor activity;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0030509 BMP signaling pathway;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XIC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810W9-1", "uniprot_id": [ { "id": "WHRN_RAT", "url": "https://www.uniprot.org/uniprot/Q810W9", "type": "external" } ], "mass": 98345.0, "length": 920, "protein_name": "Whirlin", "gene_name": "Whrn", "organism": "Rat", "refseq_name": "whirlin isoform 1", "refseq_ac": [ { "id": "NP_851602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851602", "type": "external" } ], "gene_names_uniprotkb": "Whrn; Cip98; Dfnb31", "gene_names_refseq": "Cip98; Dfnb31; Whrn", "protein_names_uniprotkb": "Whirlin; CASK-interacting protein CIP98", "protein_names_refseq": "CASK-interacting protein CIP98; deafness, autosomal recessive 31; whirlin isoform 1", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 31 (Disease Ontology:DOID:0110490); Usher syndrome type 2D (Disease Ontology:DOID:0110840); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:313255)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12641734;16434480;17584769;23055499;26516054", "class_list": "", "function": "CIP98, a novel protein (98 kDa) consisting of three PDZ domains and a proline-rich region, is widely expressed in the central nervous system and interacts with CASK (calmodulin-dependent serine kinase), [RefSeq, PubMed]; Findings indicate that Whirlin and TRPV1 are associated in a subset of nociceptors and that TRPV1 protein stability is increased through the interaction with the cytoskeletal scaffold protein., [RefSeq, PubMed]; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030426 growth cone", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0001895 retina homeostasis;GO:0045184 establishment of protein localization;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q810W9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNF0-1", "uniprot_id": [ { "id": "TM86B_RAT", "url": "https://www.uniprot.org/uniprot/B0BNF0", "type": "external" } ], "mass": 25912.0, "length": 233, "protein_name": "Lysoplasmalogenase TMEM86B", "gene_name": "Tmem86b", "organism": "Rat", "refseq_name": "lysoplasmalogenase TMEM86B isoform X1", "refseq_ac": [ { "id": "XP_063130864", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063130864", "type": "external" } ], "gene_names_uniprotkb": "Tmem86b", "gene_names_refseq": "Tmem86b", "protein_names_uniprotkb": "Lysoplasmalogenase TMEM86B; 3.3.2.2; Transmembrane protein 86B", "protein_names_refseq": "lysoplasmalogenase TMEM86B isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1482788)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21515882", "class_list": "", "function": "Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0047408 alkenylglycerophosphocholine hydrolase activity;GO:0042802 identical protein binding;GO:0047826 D-lysine 5,6-aminomutase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BNF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI51-1", "uniprot_id": [ { "id": "VTI1A_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI51", "type": "external" } ], "mass": 26043.0, "length": 224, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1A", "gene_name": "Vti1a", "organism": "Rat", "refseq_name": "vesicle transport through interaction with t-SNAREs homolog 1A", "refseq_ac": [ { "id": "NP_075589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075589", "type": "external" } ], "gene_names_uniprotkb": "Vti1a; Vti1l2", "gene_names_refseq": "DD6A4-2(1); Vti1a; Vti1", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1A; Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2", "protein_names_refseq": "SNARE Vti1a-beta protein; vesicle transport through interaction with t-SNAREs homolog 1A; vesicle transport v-SNARE protein Vti1-like 2; vti1-rp2", "tax_id": 10116, "disease": "", "pathway": " (rno:65277); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10908612;12067063;17159904;9705316", "class_list": "", "function": "Data describe a novel SNARE complex containing vti1a and vti1b, found on small synaptic vesicles and clathrin-coated vesicles isolated from nerve terminals., [RefSeq, PubMed]; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2 (By similarity). May be concerned with increased secretion of cytokines associated with cellular senescence., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI52", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050882 voluntary musculoskeletal movement;GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JI51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHX6-1", "uniprot_id": [ { "id": "TXND2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHX6", "type": "external" } ], "mass": 61103.0, "length": 550, "protein_name": "Thioredoxin domain-containing protein 2", "gene_name": "Txndc2", "organism": "Rat", "refseq_name": "thioredoxin domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001005559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005559", "type": "external" } ], "gene_names_uniprotkb": "Txndc2; Sptrx1; Sptrx", "gene_names_refseq": "Txndc2", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 2; Spermatid-specific thioredoxin-1; Sptrx-1", "protein_names_refseq": "spermatid-specific thioredoxin-1; sptrx-1; thioredoxin domain containing 2 (spermatozoa); thioredoxin domain-containing protein 2 isoform 2; thioredoxin domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316777)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12390887;22673903", "class_list": "", "function": "Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AY11", "ec_number_list": [], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XHX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924B5-1", "uniprot_id": [ { "id": "TX101_RAT", "url": "https://www.uniprot.org/uniprot/Q924B5", "type": "external" } ], "mass": 27004.0, "length": 250, "protein_name": "Testis-expressed protein 101", "gene_name": "Tex101", "organism": "Rat", "refseq_name": "testis-expressed protein 101 precursor", "refseq_ac": [ { "id": "NP_620606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620606", "type": "external" } ], "gene_names_uniprotkb": "Tex101", "gene_names_refseq": "Tec21; Tex101", "protein_names_uniprotkb": "Testis-expressed protein 101; Lipid raft-associated glycoprotein TEC-21", "protein_names_refseq": "36-42 kDa in RBL cells and 30-36 kDa in testicular cells; GPI-anchored surface glycoprotein; heavily glycosylated protein; lipid raft-associated glycoprotein TEC-21; testis expressed gene 101; testis-expressed protein 101 precursor; testis-expressed protein 101; testis-expressed sequence 101 protein-like", "tax_id": 10116, "disease": "", "pathway": " (rno:207113); (R-RNO-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11809740", "class_list": "", "function": "Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (PubMed:11809740)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044853 plasma membrane raft;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0009566 fertilization;GO:0030317 flagellated sperm motility;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0045575 basophil activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924B5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89049-1", "uniprot_id": [ { "id": "TRXR1_RAT", "url": "https://www.uniprot.org/uniprot/O89049", "type": "external" } ], "mass": 54670.0, "length": 499, "protein_name": "Thioredoxin reductase 1, cytoplasmic", "gene_name": "Txnrd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Txnrd1; Trxr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin reductase 1, cytoplasmic; 1.11.1.2; 1.8.1.9; NADPH-dependent thioredoxin reductase; Peroxidase TXNRD1; TR; Thioredoxin reductase TR1", "protein_names_refseq": "", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (R-RNO-3299685); (R-RNO-499943); (R-RNO-5263617); (R-RNO-5628897)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10333487;10849437;11481439;9535831", "class_list": "", "function": "Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis (PubMed:10849437). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U344;Q9JKZ3;Q9JKZ4;Q9R1I3", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042802 identical protein binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0045340 mercury ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008283 cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0010269 response to selenium ion;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O89049-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01134-1", "uniprot_id": [ { "id": "TGFA_RAT", "url": "https://www.uniprot.org/uniprot/P01134", "type": "external" } ], "mass": 16960.0, "length": 159, "protein_name": "Protransforming growth factor alpha", "gene_name": "Tgfa", "organism": "Rat", "refseq_name": "protransforming growth factor alpha preproprotein", "refseq_ac": [ { "id": "NP_036803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036803", "type": "external" } ], "gene_names_uniprotkb": "Tgfa", "gene_names_refseq": "RATTGFAA; TGFAA; Tgfa", "protein_names_uniprotkb": "Protransforming growth factor alpha; EGF-like TGF; ETGF; TGF type 1", "protein_names_refseq": "protransforming growth factor alpha preproprotein; protransforming growth factor alpha", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); pancreatic cancer (Disease Ontology:DOID:1793); gastroenteritis (Disease Ontology:DOID:2326); acute kidney failure (Disease Ontology:DOID:3021); insulinoma (Disease Ontology:DOID:3892); gallbladder carcinoma (Disease Ontology:DOID:4948); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24827); (R-RNO-1257604); (R-RNO-177929); (R-RNO-179812); (R-RNO-180292); (R-RNO-180336); (R-RNO-182971); (R-RNO-204005); (R-RNO-212718); (R-RNO-5673001); (R-RNO-5694530); (R-RNO-6811558); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9009391)", "pathway_count": 15, "publication_count": 7, "publication_id_list": "2325647;24595367;26804134;34968668;3855503;6320373;6605968", "class_list": "", "function": "5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway., [RefSeq, PubMed]; Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. Publication Status: Online-Only, [RefSeq, PubMed]; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transforming Growth Factor-alpha Acts in Hypothalamic Paraventricular Nucleus to Upregulate ERK1/2 Signaling and Expression of Sympathoexcitatory Mediators in Heart Failure Rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63749", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P01134-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GH61-1", "uniprot_id": [ { "id": "XK_RAT", "url": "https://www.uniprot.org/uniprot/Q5GH61", "type": "external" } ], "mass": 51050.0, "length": 445, "protein_name": "Endoplasmic reticulum membrane adapter protein XK", "gene_name": "Xk", "organism": "Rat", "refseq_name": "endoplasmic reticulum membrane adapter protein XK", "refseq_ac": [ { "id": "NP_001012227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012227", "type": "external" } ], "gene_names_uniprotkb": "Xk; Xkh; Xkr1; Xrg1", "gene_names_refseq": "Xk", "protein_names_uniprotkb": "Endoplasmic reticulum membrane adapter protein XK; Membrane transport protein XK; XK homolog; XK-related protein 1", "protein_names_refseq": "Kell blood group precursor (McLeod phenotype) homolog; X-linked Kx blood group (McLeod syndrome) homolog; XK homolog; XK-related protein 1; endoplasmic reticulum membrane adapter protein XK; membrane transport protein XK", "tax_id": 10116, "disease": "McLeod syndrome (Disease Ontology:DOID:0112107); hematopoietic system disease (Disease Ontology:DOID:74)", "pathway": " (rno:497078); (R-RNO-375276)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17379193;22673903", "class_list": "", "function": "Immunohistochemical experiments using adult rat brain indicated widespread XK immunoreactivity in the cerebral cortex, hippocampus, striatum, diencephalon and cerebellum., [RefSeq, PubMed]; Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0042552 myelination;GO:0048741 skeletal muscle fiber development;GO:0006865 amino acid transport;GO:0010961 intracellular magnesium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5GH61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPK6-1", "uniprot_id": [ { "id": "WNK4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPK6", "type": "external" } ], "mass": 132833.0, "length": 1222, "protein_name": "Serine/threonine-protein kinase WNK4", "gene_name": "Wnk4", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase WNK4", "refseq_ac": [ { "id": "NP_783169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783169", "type": "external" } ], "gene_names_uniprotkb": "Wnk4; Prkwnk4", "gene_names_refseq": "Ac2-059; Prkwnk4; Wnk4", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK4; 2.7.11.1; Protein kinase lysine-deficient 4; Protein kinase with no lysine 4", "protein_names_refseq": "WNK4 Ser/Thr kinase; protein kinase lysine-deficient 4; protein kinase with no lysine 4; serine/threonine-protein kinase WNK4", "tax_id": 10116, "disease": "", "pathway": " (rno:287715)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12642508;14608358;15883153;16083423;22513846;22673903;24811174;28493961", "class_list": "", "function": "Gene analysis of rat chromosome 10 suggest that Wnk4 does not have a role in polygenic hypertension., [RefSeq, PubMed]; In addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation., [RefSeq, PubMed]; Serine/threonine-protein kinase component of the WNK4-SPAK/OSR1 kinase cascade, which acts as a key regulator of ion transport in the distal nephron and blood pressure (By similarity). The WNK4-SPAK/OSR1 kinase cascade is composed of WNK4, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16083423). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (By similarity). Acts as a molecular switch that regulates the balance between renal salt reabsorption and K(+) secretion by modulating the activities of renal transporters and channels, including the Na-Cl cotransporter SLC12A3/NCC and the K(+) channel, KCNJ1/ROMK (By similarity). Regulates NaCl reabsorption in the distal nephron by activating the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney: activates SLC12A3/NCC in a OXSR1/OSR1- and STK39/SPAK-dependent process (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels (CFTR, KCNJ1/ROMK, SLC4A4, SLC26A9 and TRPV4) by clathrin-dependent endocytosis (By similarity). Also inhibits the activity of the epithelial Na(+) channel (ENaC) SCNN1A, SCNN1B, SCNN1D in a inase-independent mechanism (By similarity). May also phosphorylate NEDD4L (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q810H4;Q811R5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031404 chloride ion binding;GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0044297 cell body", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0003096 renal sodium ion transport;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TPK6-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99376-1", "uniprot_id": [ { "id": "TFR1_RAT", "url": "https://www.uniprot.org/uniprot/Q99376", "type": "external" } ], "mass": 85876.0, "length": 761, "protein_name": "Transferrin receptor protein 1", "gene_name": "Tfrc", "organism": "Rat", "refseq_name": "transferrin receptor protein 1", "refseq_ac": [ { "id": "NP_073203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073203", "type": "external" } ], "gene_names_uniprotkb": "Tfrc; Trfr", "gene_names_refseq": "Tfrc; Trfr", "protein_names_uniprotkb": "Transferrin receptor protein 1; TR; TfR1; TfR; Trfr", "protein_names_refseq": "TR; tfR1; tfR; transferrin receptor protein 1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); immunodeficiency 46 (Disease Ontology:DOID:0111948); prostate cancer (Disease Ontology:DOID:10283); iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); cervical adenocarcinoma (Disease Ontology:DOID:3702); nutrition disease (Disease Ontology:DOID:374); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:64678); (R-RNO-432722); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-917977); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 16, "publication_count": 8, "publication_id_list": "2126342;21454685;35038133;37105375;37683766;38241836;38843836;39251905", "class_list": "", "function": "Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis., [RefSeq, PubMed]; Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis. Erratum:[Mol Neurobiol. 2022 Aug;59(8):5252. doi: 10.1007/s12035-022-02931-2. PMID: 35727437], [RefSeq, PubMed]; METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the Intracerebral hemorrhage progression., [RefSeq, PubMed]; NAT10-mediated ac[4]C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "G3V679", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0007584 response to nutrient;GO:0010628 positive regulation of gene expression;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99376-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIH7-1", "uniprot_id": [ { "id": "WNK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIH7", "type": "external" } ], "mass": 225112.0, "length": 2126, "protein_name": "Serine/threonine-protein kinase WNK1", "gene_name": "Wnk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase WNK1 isoform 1", "refseq_ac": [ { "id": "NP_001002823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002823", "type": "external" } ], "gene_names_uniprotkb": "Wnk1; Hsn2; Prkwnk1", "gene_names_refseq": "Hsn2; Prkwnk1; Wnk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase WNK1; 2.7.11.1; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1", "protein_names_refseq": "protein kinase with no lysine 1; serine/threonine-protein kinase WNK1 isoform 1", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 2A (Disease Ontology:DOID:0070155); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:116477)", "pathway_count": 1, "publication_count": 30, "publication_id_list": "10828064;12374799;12671053;15060842;15242606;15340146;15350218;16006511;16081417;16083423;16204408;16403833;17673510;17975670;18683930;20525693;22544747;22673903;23376100;24803536;27595330;28771350;29393594;31085334;31561038;32314908;33439774;33689398;36318922;38843836", "class_list": "", "function": "A Phosphorylated Intermediate in the Activation of WNK Kinases., [RefSeq, PubMed]; Kinase-defective isoform produced by alternative promoter usage and alternative splicing., [UniProtKB, PubMed]; Kinase-defective isoform specifically expressed in kidney, which acts as a dominant-negative regulator of the longer isoform 1 (PubMed:16204408). Does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport (PubMed:16204408). Down-regulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity (PubMed:16204408). In kidney, may play an important role regulating sodium and potassium balance (PubMed:16204408)., [UniProtKB, PubMed]; Osmosensing by WNK Kinases., [RefSeq, PubMed]; Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders., [RefSeq, PubMed]; Serine/threonine-protein kinase component of the WNK1-SPAK/OSR1 kinase cascade, which acts as a key regulator of blood pressure and regulatory volume increase by promoting ion influx (PubMed:10828064, PubMed:12374799, PubMed:16083423, PubMed:17975670, PubMed:24803536, PubMed:36318922). WNK1 mediates regulatory volume increase in response to hyperosmotic stress by acting as a molecular crowding sensor, which senses cell shrinkage and mediates formation of a membraneless compartment by undergoing liquid-liquid phase separation (PubMed:36318922). The membraneless compartment concentrates WNK1 with its substrates, OXSR1/OSR1 and STK39/SPAK, promoting WNK1-dependent phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (PubMed:16083423, PubMed:36318922). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A5/KCC2 and SLC12A6/KCC3, regulating their activity (PubMed:22544747, PubMed:36318922). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:36318922). Also acts as a regulator of angiogenesis in endothelial cells (By similarity). Also acts independently of the WNK1-SPAK/OSR1 kinase cascade by catalyzing phosphorylation of other substrates, such as SYT2, PCF11 and NEDD4L (PubMed:15350218, PubMed:20525693). Mediates phosphorylation of SYT2, regulating SYT2 association with phospholipids and membrane-binding (PubMed:15350218). Regulates mRNA export in the nucleus by mediating phosphorylation of PCF11, thereby decreasing the association between PCF11 and POLR2A/RNA polymerase II and promoting mRNA export to the cytoplasm (By similarity). Acts as a negative regulator of autophagy (By similarity). Required for the abscission step during mitosis, independently of the WNK1-SPAK/OSR1 kinase cascade (By similarity). WNK1 may also play a role in actin cytoskeletal reorganization (By similarity). Also acts as a scaffold protein independently of its protein kinase activity: negatively regulates cell membrane localization of various transporters and channels, such as SLC4A4, SLC26A6, SLC26A9, TRPV4 and CFTR (PubMed:16403833, PubMed:17673510). Involved in the regulation of epithelial Na(+) channel (ENaC) by promoting activation of SGK1 in a kinase-independent manner (PubMed:16006511, PubMed:16081417). Probably activates SGK1 by acting as a scaffold protein that promotes the recruitment of SGK1 to the mTORC2 complex in response to chloride, leading to mTORC2-dependent phosphorylation and activation of SGK1 (By similarity). Acts as an assembly factor for the ER membrane protein complex independently of its protein kinase activity: associates with EMC2 in the cytoplasm via its amphipathic alpha-helix, and prevents EMC2 ubiquitination and subsequent degradation, thereby promoting EMC2 stabilization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2., [RefSeq, PubMed]; WNK1 has a role in the sodium regulatory pathway of the distal, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3S2I2;Q6IFS7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0030644 intracellular chloride ion homeostasis;GO:0033633 negative regulation of cell-cell adhesion mediated by integrin;GO:0006468 protein phosphorylation;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9JIH7-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LNJ2-1", "uniprot_id": [ { "id": "U520_RAT", "url": "https://www.uniprot.org/uniprot/F1LNJ2", "type": "external" } ], "mass": 244875.0, "length": 2139, "protein_name": "U5 small nuclear ribonucleoprotein 200 kDa helicase", "gene_name": "Snrnp200", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snrnp200", "gene_names_refseq": "", "protein_names_uniprotkb": "U5 small nuclear ribonucleoprotein 200 kDa helicase; 3.6.4.13; BRR2 homolog; U5 snRNP-specific 200 kDa protein; U5-200KD", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinitis pigmentosa 33 (Disease Ontology:DOID:0110366); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:296126); (R-RNO-72163); (R-RNO-72165)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LNJ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5K6-1", "uniprot_id": [ { "id": "TOB1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5K6", "type": "external" } ], "mass": 40461.0, "length": 365, "protein_name": "Protein Tob1", "gene_name": "Tob1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tob1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Tob1; Transducer of erbB-2 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:170842)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21336257", "class_list": "", "function": "Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0030971 receptor tyrosine kinase binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0060390 regulation of SMAD protein signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0030514 negative regulation of BMP signaling pathway;GO:0017148 negative regulation of translation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5K6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04633-1", "uniprot_id": [ { "id": "UCP1_RAT", "url": "https://www.uniprot.org/uniprot/P04633", "type": "external" } ], "mass": 33212.0, "length": 307, "protein_name": "Mitochondrial brown fat uncoupling protein 1", "gene_name": "Ucp1", "organism": "Rat", "refseq_name": "mitochondrial brown fat uncoupling protein 1", "refseq_ac": [ { "id": "NP_036814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036814", "type": "external" } ], "gene_names_uniprotkb": "Ucp1; Slc25a7; Ucp", "gene_names_refseq": "Ucp1; Ucpa; Ucp; Uncp", "protein_names_uniprotkb": "Mitochondrial brown fat uncoupling protein 1; Solute carrier family 25 member 7; Thermogenin; UCP 1", "protein_names_refseq": "UCP 1; mitochondrial brown fat uncoupling protein 1-like; mitochondrial brown fat uncoupling protein 1; solute carrier family 25 member 7; thermogenin; uncoupling protein 1 (mitochondrial, proton carrier)", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24860); (R-RNO-166187); (R-RNO-167826)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12479871;16814247;22531154;22952235;2421800;3012461;30624981;3202878;33202085;33441773;33815288;36650072;3753702;7691596", "class_list": "", "function": "Instead of UCP1-mediated mitochondrial uncoupling, cold acclimation increased the capacity of Sc Ing adipocytes to export fatty acids., [RefSeq, PubMed]; Maternal Roux-en-Y gastric bypass surgery reduces lipid deposition and increases UCP1 expression in the brown adipose tissue of male offspring. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs (PubMed:12479871, PubMed:16814247, PubMed:22952235). Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge., [RefSeq, PubMed]; Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005525 GTP binding;GO:0022857 transmembrane transporter activity;GO:0019003 GDP binding;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070417 cellular response to cold;GO:0009893 positive regulation of metabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006839 mitochondrial transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P04633-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21643-1", "uniprot_id": [ { "id": "T23O_RAT", "url": "https://www.uniprot.org/uniprot/P21643", "type": "external" } ], "mass": 47857.0, "length": 406, "protein_name": "Tryptophan 2,3-dioxygenase", "gene_name": "Tdo2", "organism": "Rat", "refseq_name": "tryptophan 2,3-dioxygenase", "refseq_ac": [ { "id": "NP_071798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071798", "type": "external" } ], "gene_names_uniprotkb": "Tdo2; Tdo", "gene_names_refseq": "TO; Tdo2; Tdo", "protein_names_uniprotkb": "Tryptophan 2,3-dioxygenase; 1.13.11.11; TDO; TO; TRPO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase", "protein_names_refseq": "TRPO; tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-23-dioxygenase; tryptophanase", "tax_id": 10116, "disease": "familial hypertryptophanemia (Disease Ontology:DOID:0111703); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:64206); (R-RNO-71240)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1511007;22673903;2372286;3582368;6327261", "class_list": "", "function": "Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBC2;Q6LBW3", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" }, { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0020037 heme binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0045471 response to ethanol;GO:0051289 protein homotetramerization;GO:0006568 L-tryptophan metabolic process;GO:0051414 response to cortisol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21643-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63045-1", "uniprot_id": [ { "id": "VAMP2_RAT", "url": "https://www.uniprot.org/uniprot/P63045", "type": "external" } ], "mass": 12691.0, "length": 116, "protein_name": "Vesicle-associated membrane protein 2", "gene_name": "Vamp2", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 2 isoform 1", "refseq_ac": [ { "id": "NP_036795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036795", "type": "external" } ], "gene_names_uniprotkb": "Vamp2; Syb2", "gene_names_refseq": "RATVAMPB; RATVAMPIR; SYB; Syb2; Vamp2", "protein_names_uniprotkb": "Vesicle-associated membrane protein 2; Synaptobrevin-2; VAMP-2", "protein_names_refseq": "Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); VAMP-2; Vesicle-associated membrane protein (synaptobrevin 2); synaptobrevin-2; vesicle-associated membrane protein 2 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:24803); (R-RNO-181429); (R-RNO-181430); (R-RNO-199992); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-432720); (R-RNO-432722); (R-RNO-449836); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-888590); (R-RNO-9609523)", "pathway_count": 14, "publication_count": 15, "publication_id_list": "11832227;12496247;1331807;19196426;19690160;2472388;28770820;32210233;32467162;33513363;34496238;7910017;8175689;8505288;9759724", "class_list": "", "function": "By using in-cell NMR spectroscopy study described the dynamic membrane association of rat VAMP2 SNARE motif in mammalian cells, and the structural change of VAMP2 upon the change of intracellular lipis. In contrast to the non-raft region, the membrane region of cholesterol-rich lipid raft markedly weakens the membrane association of VAMP2 SNARE motif, which releases the SNARE motif and facilitates the SNARE assembly. Publication Status: Online-Only, [RefSeq, PubMed]; Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles., [RefSeq, PubMed]; PI(4,5)P2-dependent regulation of exocytosis by amisyn, the vertebrate-specific competitor of synaptobrevin 2., [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:12496247, PubMed:19690160, PubMed:9759724). VAMP2 is a v-SNARE assembling into a SNARE complex with the t-SNAREs SNAP25 and STX1A to mediate the fusion of synaptic vesicles with the presynaptic plasma membrane in neurotransmitter release (PubMed:1331807). Also functions in compensatory endocytosis for synaptic vesicle recycling (By similarity). In adipocytes, it is involved in the insulin-dependent exocytosis of GLUT4 storage vesicles (By similarity). Independently of its SNARE activity, it could modulate the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19690160)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The vSNAREs VAMP2 and VAMP4 control recycling and intracellular sorting of post-synaptic receptors in neuronal dendrites., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64357", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1902259 regulation of delayed rectifier potassium channel activity;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0045055 regulated exocytosis;GO:0090316 positive regulation of intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P63045-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR2-1", "uniprot_id": [ { "id": "TYPH_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR2", "type": "external" } ], "mass": 49901.0, "length": 476, "protein_name": "Thymidine phosphorylase", "gene_name": "Sco2; Tymp", "organism": "Rat", "refseq_name": "thymidine phosphorylase", "refseq_ac": [ { "id": "NP_001012122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012122", "type": "external" } ], "gene_names_uniprotkb": "Sco2; Tymp; Ecgf1; Tymp", "gene_names_refseq": "Ecgf1; TP; Tymp", "protein_names_uniprotkb": "Thymidine phosphorylase; 2.4.2.4; TP; TdRPase", "protein_names_refseq": "endothelial cell growth factor 1 (platelet-derived); tdRPase; thymidine phosphorylase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); ductal carcinoma in situ (Disease Ontology:DOID:0060074); mitochondrial DNA depletion syndrome 1 (Disease Ontology:DOID:0080119); mitochondrial complex IV deficiency nuclear type 2 (Disease Ontology:DOID:0080357); urinary bladder cancer (Disease Ontology:DOID:11054); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver disease (Disease Ontology:DOID:409); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); common bile duct neoplasm (Disease Ontology:DOID:4608); gallbladder carcinoma (Disease Ontology:DOID:4948); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:315219); (R-RNO-73614); (R-RNO-73621)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)., [UniProtKB]; Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004645 1,4-alpha-oligoglucan phosphorylase activity;GO:0009032 thymidine phosphorylase activity;GO:0005507 copper ion binding;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006213 pyrimidine nucleoside metabolic process;GO:0006206 pyrimidine nucleobase metabolic process;GO:0046074 dTMP catabolic process;GO:0006878 intracellular copper ion homeostasis;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVR2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00406-1", "uniprot_id": [ { "id": "COX2_RAT", "url": "https://www.uniprot.org/uniprot/P00406", "type": "external" } ], "mass": 25928.0, "length": 227, "protein_name": "Cytochrome c oxidase subunit 2", "gene_name": "Mt-co2", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit II", "refseq_ac": [ { "id": "YP_665632", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665632", "type": "external" } ], "gene_names_uniprotkb": "Mt-co2; COX2; Coii; Mtco2", "gene_names_refseq": "COII; COX2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 2; 7.1.1.9; Cytochrome c oxidase polypeptide II", "protein_names_refseq": "cytochrome c oxidase subunit II", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); stomach cancer (Disease Ontology:DOID:10534); Huntington's disease (Disease Ontology:DOID:12858); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:26198); (R-RNO-5419276); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564); (R-RNO-9864848)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "1848093;22673903;2504926;6091655;6285344;7981121", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q37738;Q80WI7", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0045907 positive regulation of vasoconstriction;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P00406-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJK8-1", "uniprot_id": [ { "id": "GOLI4_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJK8", "type": "external" } ], "mass": 76597.0, "length": 653, "protein_name": "Golgi integral membrane protein 4", "gene_name": "Golim4", "organism": "Rat", "refseq_name": "Golgi integral membrane protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001386398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386398", "type": "external" } ], "gene_names_uniprotkb": "Golim4; Gimpc; Golph4", "gene_names_refseq": "Golim4; Golph4", "protein_names_uniprotkb": "Golgi integral membrane protein 4; GIMPc; Golgi integral membrane protein, cis; Golgi phosphoprotein 4", "protein_names_refseq": "GIMPc; Golgi integral membrane protein 4 isoform 2; golgi integral membrane protein, cis; golgi phosphoprotein 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;3301866", "class_list": "", "function": "Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0010008 endosome membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BJK8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AAL4-1", "uniprot_id": [ { "id": "A0A8I6AAL4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AAL4", "type": "external" } ], "mass": 19174.0, "length": 168, "protein_name": "Cilia- and flagella-associated protein HOATZ", "gene_name": "Hoatz", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein HOATZ isoform X1", "refseq_ac": [ { "id": "XP_017451516", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017451516", "type": "external" } ], "gene_names_uniprotkb": "Hoatz; LOC100359479", "gene_names_refseq": "Hoatz", "protein_names_uniprotkb": "Cilia- and flagella-associated protein HOATZ", "protein_names_refseq": "cilia- and flagella-associated protein HOATZ isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:100359479)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AAL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10868-1", "uniprot_id": [ { "id": "GAMT_RAT", "url": "https://www.uniprot.org/uniprot/P10868", "type": "external" } ], "mass": 26407.0, "length": 236, "protein_name": "Guanidinoacetate N-methyltransferase", "gene_name": "Gamt", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gamt", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanidinoacetate N-methyltransferase; 2.1.1.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "guanidinoacetate methyltransferase deficiency (Disease Ontology:DOID:0050799); pre-eclampsia (Disease Ontology:DOID:10591); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (R-RNO-71288)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11165387;12079381;12925789;15533043;15918910;1990977;22673903;3277179;3419933", "class_list": "", "function": "Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0030731 guanidinoacetate N-methyltransferase activity;GO:0042802 identical protein binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1990402 embryonic liver development;GO:0007283 spermatogenesis;GO:0040014 regulation of multicellular organism growth;GO:0009887 animal organ morphogenesis;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10868-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02091-1", "uniprot_id": [ { "id": "HBB1_RAT", "url": "https://www.uniprot.org/uniprot/P02091", "type": "external" } ], "mass": 15979.0, "length": 147, "protein_name": "Hemoglobin subunit beta-1", "gene_name": "Hbb", "organism": "Rat", "refseq_name": "hemoglobin subunit beta-1", "refseq_ac": [ { "id": "NP_150237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150237", "type": "external" } ], "gene_names_uniprotkb": "Hbb", "gene_names_refseq": "Hbb-b1; Hbb", "protein_names_uniprotkb": "Hemoglobin subunit beta-1; Beta-1-globin; Hemoglobin beta chain, major-form; Hemoglobin beta-1 chain", "protein_names_refseq": "III beta-1 globin; III beta-2 globin; beta-1-globin; hemoglobin beta chain complex; hemoglobin beta chain, major-form; hemoglobin beta-1 chain; hemoglobin subunit beta-1; hemoglobin subunit beta; hemoglobin, beta", "tax_id": 10116, "disease": "autosomal dominant beta thalassemia (Disease Ontology:DOID:0080770); delta beta-thalassemia (Disease Ontology:DOID:0080773); sickle cell disease (Disease Ontology:DOID:0081445); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 6 (Disease Ontology:DOID:0111632); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); beta thalassemia (Disease Ontology:DOID:12241); malaria (Disease Ontology:DOID:12365); Parkinson's disease (Disease Ontology:DOID:14330); acute chest syndrome (Disease Ontology:DOID:1584); anemia (Disease Ontology:DOID:2355); hemoglobin C disease (Disease Ontology:DOID:2859); hemoglobinopathy (Disease Ontology:DOID:2860); congenital hemolytic anemia (Disease Ontology:DOID:589); polycythemia (Disease Ontology:DOID:8432)", "pathway": " (rno:24440); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-2168880); (R-RNO-6798695); (R-RNO-9707564); (R-RNO-9707616)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "22673903;2587229;2740220;29393594;3619896;8334153", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P33584", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0030492 hemoglobin binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0042542 response to hydrogen peroxide;GO:0030097 hemopoiesis;GO:0042744 hydrogen peroxide catabolic process;GO:0015670 carbon dioxide transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02091-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C170-1", "uniprot_id": [ { "id": "H2A1E_RAT", "url": "https://www.uniprot.org/uniprot/P0C170", "type": "external" } ], "mass": 14119.0, "length": 130, "protein_name": "Histone H2A type 1-E", "gene_name": "", "organism": "Rat", "refseq_name": "histone H2A type 1-E", "refseq_ac": [ { "id": "NP_001302421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001302421", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "H2A.1; Hist1h2ah", "protein_names_uniprotkb": "Histone H2A type 1-E", "protein_names_refseq": "histone H2A type 1-E; histone cluster 1, H2ah", "tax_id": 10116, "disease": "", "pathway": " (rno:103690190); (rno:502125); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "1268188;19343714;21239733", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C170-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11517-1", "uniprot_id": [ { "id": "HBB2_RAT", "url": "https://www.uniprot.org/uniprot/P11517", "type": "external" } ], "mass": 15982.0, "length": 147, "protein_name": "Hemoglobin subunit beta-2", "gene_name": "", "organism": "Rat", "refseq_name": "hemoglobin subunit beta-2", "refseq_ac": [ { "id": "NP_001104739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104739", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "Hbb-bs; Hbb-bt", "protein_names_uniprotkb": "Hemoglobin subunit beta-2; Beta-2-globin; Hemoglobin beta chain, minor-form; Hemoglobin beta-2 chain", "protein_names_refseq": "III beta-3 globin; beta-2-globin; beta-globin; beta-hemoglobin; hemoglobin beta chain, minor-form; hemoglobin beta-2 chain; hemoglobin subunit beta-2; hemoglobin, beta adult s chain", "tax_id": 10116, "disease": "", "pathway": " (rno:100134871); (rno:120093065); (rno:689064)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "22673903;2587229;2748344;29393594;3357786;3453111", "class_list": "", "function": "Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0045646 regulation of erythrocyte differentiation;GO:0045639 positive regulation of myeloid cell differentiation;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P11517-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31392-1", "uniprot_id": [ { "id": "ACKR5_RAT", "url": "https://www.uniprot.org/uniprot/P31392", "type": "external" } ], "mass": 45188.0, "length": 398, "protein_name": "Atypical chemokine receptor 5", "gene_name": "Ackr5", "organism": "Rat", "refseq_name": "atypical chemokine receptor 5", "refseq_ac": [ { "id": "NP_445754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445754", "type": "external" } ], "gene_names_uniprotkb": "Ackr5; Admr; Gpr182", "gene_names_refseq": "Ackr5; Admr; Gpr182", "protein_names_uniprotkb": "Atypical chemokine receptor 5; G protein-coupled receptor 182; G10D; NOW", "protein_names_refseq": "G protein-coupled receptor 182; G10D; NOW; adrenomedullin receptor; atypical chemokine receptor 5", "tax_id": 10116, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:29307)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11676473;11967020;17898545;17982694;18401014;20431304;21454685;22673903;25061099;29393594;7592696;8382168;8390839;9535752", "class_list": "", "function": "Adrenomedullin inhibits CaCl(2)-induced contraction, without affecting calcium influx, through a CGRP(8-37)-sensitive receptor, but not using the cyclic adenosine monophosphate pathway, probably through activation of protein phosphatases., [RefSeq, PubMed]; Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization. Instead, it mediates chemokine sequestration, transport, or internalization to control their availability. Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and XCL1. Is the only atypical receptor for chemokines CXCL13 and CCL28. Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding. Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively (By similarity). Acts as an important modulator of cellular immunity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that the adrenomedullin receptor subtypes AM1-R and AM2-R are up-regulated in enucleated adrenals, and that this effect depends on the increased local production of AM., [RefSeq, PubMed]; Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2)., [RefSeq, PubMed]; Nitric oxide increases adrenomedullin receptor function in rat mesangial cells, [RefSeq, PubMed]; Study demonstrates that glomerular gene expression of ADM and its receptors are downregulated during anti-Thy1 glomerulonephritis, [RefSeq, PubMed]; The increase in functional adrenomedullin receptor during phenotypic change may in part contribute to the development of vascular lesions, [RefSeq, PubMed]; The presence of ADM and the gene expression of ADM and its receptor components in the female reproductive system suggest a paracrine effect of ADM on ovarian steroidogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6AT50;A1L1I2;A6HQX3;D3ZC02;Q64166", "ec_number_list": [], "go_molecular_function": "GO:0019957 C-C chemokine binding;GO:0019958 C-X-C chemokine binding;GO:0001605 adrenomedullin receptor activity;GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P31392-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64298-1", "uniprot_id": [ { "id": "MCSP_RAT", "url": "https://www.uniprot.org/uniprot/Q64298", "type": "external" } ], "mass": 15148.0, "length": 145, "protein_name": "Sperm mitochondrial-associated cysteine-rich protein", "gene_name": "Smcp", "organism": "Rat", "refseq_name": "sperm mitochondrial-associated cysteine-rich protein", "refseq_ac": [ { "id": "NP_113724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113724", "type": "external" } ], "gene_names_uniprotkb": "Smcp; Mcsp; Mcs", "gene_names_refseq": "Mcsp; Mcs; Smcp", "protein_names_uniprotkb": "Sperm mitochondrial-associated cysteine-rich protein", "protein_names_refseq": "sperm mitochondrial-associated cysteine-rich protein", "tax_id": 10116, "disease": "", "pathway": " (rno:24899)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16159880;19423663;22673903;8634143;8916043", "class_list": "", "function": "Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity)., [UniProtKB, UniProtKB]; PHGPx interacts with SMCP; the cysteine motif of PHGPx is a new substrate of the selenoperoxidase, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0030317 flagellated sperm motility;GO:0007341 penetration of zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64298-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1K8-1", "uniprot_id": [ { "id": "GRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1K8", "type": "external" } ], "mass": 90245.0, "length": 795, "protein_name": "RAS guanyl-releasing protein 1", "gene_name": "Rasgrp1", "organism": "Rat", "refseq_name": "RAS guanyl-releasing protein 1", "refseq_ac": [ { "id": "NP_062084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062084", "type": "external" } ], "gene_names_uniprotkb": "Rasgrp1; Rasgrp", "gene_names_refseq": "Rasgrp1; Rasgrp", "protein_names_uniprotkb": "RAS guanyl-releasing protein 1; CalDAG-GEFII; Calcium and DAG-regulated guanine nucleotide exchange factor II; Ras guanyl-releasing protein", "protein_names_refseq": "CalDAG-GEF1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; calDAG-GEFII; calcium and DAG-regulated guanine nucleotide exchange factor II", "tax_id": 10116, "disease": "immunodeficiency 64 (Disease Ontology:DOID:0111980); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:29434); (R-RNO-1169092); (R-RNO-354192); (R-RNO-392517); (R-RNO-5673001)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10779365;11279364;11738253;12626538;15064353;22673903;9582122;9789079", "class_list": "", "function": "Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9582122, PubMed:9789079). Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity;GO:0003682 chromatin binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AMN9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6B646-1", "uniprot_id": [ { "id": "A0A8I6B646_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6B646", "type": "external" } ], "mass": 28145.0, "length": 251, "protein_name": "Ankyrin repeat domain 66", "gene_name": "Ankrd66", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 66 isoform X1", "refseq_ac": [ { "id": "XP_006244680", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244680", "type": "external" } ], "gene_names_uniprotkb": "Ankrd66", "gene_names_refseq": "Ankrd66", "protein_names_uniprotkb": "Ankyrin repeat domain 66", "protein_names_refseq": "ankyrin repeat domain-containing protein 66 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:501105)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", 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"biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070198 protein localization to chromosome, telomeric region;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1904355 positive regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6B646-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8J8Y7C5-1", "uniprot_id": [ { "id": "A0A8J8Y7C5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8J8Y7C5", "type": "external" } ], "mass": 49435.0, "length": 448, "protein_name": "SPARC related modular calcium binding 1", "gene_name": "Smoc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smoc1", "gene_names_refseq": "", "protein_names_uniprotkb": "SPARC related modular calcium binding 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "microphthalmia with limb anomalies (Disease Ontology:DOID:0060861)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8J8Y7C5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AKZ1-1", "uniprot_id": [ { "id": "A0A8I6AKZ1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AKZ1", "type": "external" } ], "mass": 43970.0, "length": 405, "protein_name": "Potassium channel tetramerization domain containing 17", "gene_name": "Kctd17", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kctd17", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium channel tetramerization domain containing 17", "protein_names_refseq": "", "tax_id": 10116, "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033); myoclonic dystonia 26 (Disease Ontology:DOID:0090036)", "pathway": " (rno:300317)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": 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"glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AKZ1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AK45-1", "uniprot_id": [ { "id": "A0A8I6AK45_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AK45", "type": "external" } ], "mass": 46001.0, "length": 421, "protein_name": "Mitochondrial carrier homolog 2", "gene_name": "Mtch2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mtch2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial carrier homolog 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0090152 establishment of protein localization to mitochondrial membrane involved in mitochondrial fission;GO:0070585 protein localization to mitochondrion;GO:0045040 protein insertion into mitochondrial outer membrane;GO:0043065 positive regulation of apoptotic process;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8I6AK45-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZRW0-1", "uniprot_id": [ { "id": "A0A8I5ZRW0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZRW0", "type": "external" } ], "mass": 8441.0, "length": 76, "protein_name": "Small nuclear ribonucleoprotein G", "gene_name": "Snrpg", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snrpg; LOC687679; Snrpg-ps8; Snrpgl1; Snrpgl2", "gene_names_refseq": "", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein G; snRNP-G", "protein_names_refseq": "", "tax_id": 10116, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:681031); (R-RNO-111367); (R-RNO-191859); (R-RNO-72163); (R-RNO-72165); (R-RNO-73856); (R-RNO-77588); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990446 U1 snRNP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZRW0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G404-1", "uniprot_id": [ { "id": "A0A8I6G404_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G404", "type": "external" } ], "mass": 666761.0, "length": 6192, "protein_name": "Zonadhesin", "gene_name": "Zan", "organism": "Rat", "refseq_name": "zonadhesin isoform X3", "refseq_ac": [ { "id": "XP_038945982", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038945982", "type": "external" } ], "gene_names_uniprotkb": "Zan", "gene_names_refseq": "Zan", "protein_names_uniprotkb": "Zonadhesin", "protein_names_refseq": "zonadhesin isoform X3", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:2000359 regulation of binding of sperm to zona pellucida", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6G404-1", "record_type": "protein", "filter_code": "0000000.0000000.000100.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AK91-1", "uniprot_id": [ { "id": "A0A8I6AK91_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AK91", "type": "external" } ], "mass": 73690.0, "length": 646, "protein_name": "G-protein coupled receptors family 3 profile domain-containing protein", "gene_name": "LOC134484845", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC134484845; LOC134484837; LOC134484840; Vom2r4l1", "gene_names_refseq": "", "protein_names_uniprotkb": "G-protein coupled receptors family 3 profile domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AK91-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALM9-1", "uniprot_id": [ { "id": "A0A8I6ALM9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALM9", "type": "external" } ], "mass": 119177.0, "length": 1079, "protein_name": "Inactive tyrosine-protein kinase 7", "gene_name": "Ptk7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptk7", "gene_names_refseq": "", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "scoliosis (Disease Ontology:DOID:0060249); idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (rno:301242); (R-RNO-8863795)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0016055 Wnt signaling pathway;GO:0007507 heart development;GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALM9-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AKZ2-1", "uniprot_id": [ { "id": "A0A8I6AKZ2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AKZ2", "type": "external" } ], "mass": 63240.0, "length": 553, "protein_name": "TRAF3 interacting protein 3", "gene_name": "Traf3ip3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Traf3ip3", "gene_names_refseq": "", "protein_names_uniprotkb": "TRAF3 interacting protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0044198 zf-TRAF domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0035457 cellular response to interferon-alpha;GO:0035458 cellular response to interferon-beta;GO:0032481 positive regulation of type I interferon production;GO:0032728 positive regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AKZ2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALM7-1", "uniprot_id": [ { "id": "A0A8I6ALM7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALM7", "type": "external" } ], "mass": 51515.0, "length": 470, "protein_name": "UEV and lactate/malate dehyrogenase domains", "gene_name": "Uevld", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Uevld; LOC688000", "gene_names_refseq": "", "protein_names_uniprotkb": "UEV and lactate/malate dehyrogenase domains", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000813 ESCRT I complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031982 vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0008333 endosome to lysosome transport;GO:0019752 carboxylic acid metabolic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALM7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALV4-1", "uniprot_id": [ { "id": "A0A8I6ALV4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALV4", "type": "external" } ], "mass": 41761.0, "length": 372, "protein_name": "Histidine--tRNA ligase, cytoplasmic", "gene_name": "ENSRNOG00000064147", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000064147", "gene_names_refseq": "", "protein_names_uniprotkb": "Histidine--tRNA ligase, cytoplasmic; 6.1.1.21; Histidyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALV4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GA89-1", "uniprot_id": [ { "id": "A0A8I6GA89_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GA89", "type": "external" } ], "mass": 61072.0, "length": 549, "protein_name": "Uridine-cytidine kinase", "gene_name": "Uckl1", "organism": "Rat", "refseq_name": "uridine-cytidine kinase-like 1 isoform X1", "refseq_ac": [ { "id": "XP_038961641", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038961641", "type": "external" } ], "gene_names_uniprotkb": "Uckl1", "gene_names_refseq": "RGD1565465; Uckl1", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GA89-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AP01-1", "uniprot_id": [ { "id": "A0A8I6AP01_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AP01", "type": "external" } ], "mass": 99532.0, "length": 883, "protein_name": "Integrator complex subunit 6", "gene_name": "Ints6", "organism": "Rat", "refseq_name": "integrator complex subunit 6", "refseq_ac": [ { "id": "NP_001258417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258417", "type": "external" } ], "gene_names_uniprotkb": "Ints6", "gene_names_refseq": "Ddx26; 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It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, 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Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. 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(R-RNO-198933); (R-RNO-202733); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2168880); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5690714); (R-RNO-977606); (R-RNO-983695)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GC23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GDH2-1", "uniprot_id": [ { "id": "A0A8I6GDH2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GDH2", "type": "external" } ], "mass": 34295.0, "length": 305, "protein_name": "Olfactory receptor", "gene_name": "LOC120101452", "organism": "Rat", "refseq_name": "olfactory receptor 4A15-like", "refseq_ac": [ { "id": "XP_038962000", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038962000", "type": "external" } ], "gene_names_uniprotkb": "LOC120101452", "gene_names_refseq": "LOC120101452", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 4A15-like", "tax_id": 10116, "disease": "", "pathway": " (rno:120101452)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GDH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GEX2-1", "uniprot_id": [ { "id": "A0A8I6GEX2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GEX2", "type": "external" } ], "mass": 120597.0, "length": 1099, "protein_name": "R3H domain containing 1", "gene_name": "R3hdm1", "organism": "Rat", "refseq_name": "R3H domain-containing protein 1 isoform X3", "refseq_ac": [ { "id": "XP_008767682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008767682", "type": "external" } ], "gene_names_uniprotkb": "R3hdm1", "gene_names_refseq": "R3hdm1; R3hdm", "protein_names_uniprotkb": "R3H domain containing 1", "protein_names_refseq": "R3H domain-containing protein 1 isoform X3", "tax_id": 10116, "disease": "", "pathway": " (rno:304763)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GEX2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GHH3-1", "uniprot_id": [ { "id": "A0A8I6GHH3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GHH3", "type": "external" } ], "mass": 26449.0, "length": 240, "protein_name": "SH3 domain-binding glutamic acid-rich-like protein 1", "gene_name": "Sh3bgrl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh3bgrl; Sh3bgrl1", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3 domain-binding glutamic acid-rich-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs. May function as a ubiquitin ligase-substrate adapter. Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:1904690 positive regulation of cytoplasmic translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GHH3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GHU7-1", "uniprot_id": [ { "id": "A0A8I6GHU7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GHU7", "type": "external" } ], "mass": 115005.0, "length": 1030, "protein_name": "Multimerin-2", "gene_name": "Mmrn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mmrn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Multimerin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5173105)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Extracellular matrix protein that plays significant roles in the vascular system and is required for the maintenance and stability of blood vessel. Affects several essential steps in angiogenesis including endothelial cell proliferation, migration, and tube formation. Positively regulates angiogenesis by acting as a ligand for CD93 receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GHU7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GIL4-1", "uniprot_id": [ { "id": "A0A8I6GIL4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GIL4", "type": "external" } ], "mass": 63852.0, "length": 559, "protein_name": "Transmembrane protein 87A", "gene_name": "Tmem87a", "organism": "Rat", "refseq_name": "transmembrane protein 87A precursor", "refseq_ac": [ { "id": "NP_001414659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414659", "type": "external" } ], "gene_names_uniprotkb": "Tmem87a", "gene_names_refseq": "RGD1309417; Tmem87a", "protein_names_uniprotkb": "Transmembrane protein 87A", "protein_names_refseq": "transmembrane protein 87A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:366170); (R-RNO-8980692)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0071260 cellular response to mechanical stimulus;GO:0042147 retrograde transport, endosome to Golgi;GO:0051452 intracellular pH reduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GIL4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GIV1-1", "uniprot_id": [ { "id": "A0A8I6GIV1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GIV1", "type": "external" } ], "mass": 18875.0, "length": 170, "protein_name": "Alpha-ketoglutarate dehydrogenase subunit 4", "gene_name": "Kgd4", "organism": "Rat", "refseq_name": "alpha-ketoglutarate dehydrogenase component 4 isoform X1", "refseq_ac": [ { "id": "XP_063137571", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063137571", "type": "external" } ], "gene_names_uniprotkb": "Kgd4; Mrps36", "gene_names_refseq": "Kgd4; Mrps36", "protein_names_uniprotkb": "Alpha-ketoglutarate dehydrogenase subunit 4", "protein_names_refseq": "alpha-ketoglutarate dehydrogenase component 4 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5389840); (R-RNO-5419276); (R-RNO-6783984); (R-RNO-9853506); (R-RNO-9937383)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045252 oxoglutarate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GIV1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GJ95-1", "uniprot_id": [ { "id": "DHB14_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ95", "type": "external" } ], "mass": 28157.0, "length": 270, "protein_name": "L-fucose dehydrogenase", "gene_name": "Hsd17b14", "organism": "Rat", "refseq_name": "L-fucose dehydrogenase", "refseq_ac": [ { "id": "NP_001178040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178040", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b14", "gene_names_refseq": "Dhrs10; Hsd17b14", "protein_names_uniprotkb": "L-fucose dehydrogenase; 1.1.1.122; Hydroxysteroid 17-beta dehydrogenase 14", "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase 14; L-fucose dehydrogenase; dehydrogenase/reductase (SDR family) member 10", "tax_id": 10116, "disease": "", "pathway": " (rno:691018); (R-RNO-193144)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38944119", "class_list": "", "function": "Catalyzes the NAD(+)-dependent oxidation of L-fucose, yielding L-fucono-1,5-lactone, which rapidly converts spontaneously to L-fucone-1,4-lactone. Does not use NADPH (PubMed:38944119). Displays low activity on L-fucose, D-arabinose and L-galactose compared with rabbit and human (PubMed:38944119). This is consitent with the low L-fucose metabolism observed in this species (PubMed:38944119)., [UniProtKB, PubMed]; NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0047834 D-threo-aldose 1-dehydrogenase activity;GO:0016491 oxidoreductase activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005777 peroxisome", "go_biological_process": "GO:0042355 L-fucose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GJ95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GJR0-1", "uniprot_id": [ { "id": "A0A8I6GJR0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GJR0", "type": "external" } ], "mass": 42592.0, "length": 379, "protein_name": "Aspartate aminotransferase", "gene_name": "Got2-ps6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Got2-ps6", "gene_names_refseq": "", "protein_names_uniprotkb": "Aspartate aminotransferase; 2.6.1.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 82 (Disease Ontology:DOID:0080715)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" }, { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" } ], "go_molecular_function": "GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006533 L-aspartate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GJR0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GKF2-1", "uniprot_id": [ { "id": "A0A8I6GKF2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GKF2", "type": "external" } ], "mass": 36822.0, "length": 326, "protein_name": "Retinoic acid early-inducible protein 1-gamma-like", "gene_name": "LOC120097698", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC120097698", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid early-inducible protein 1-gamma-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a ligand for KLRK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GKF2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GKT6-1", "uniprot_id": [ { "id": "A0A8I6GKT6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GKT6", "type": "external" } ], "mass": 96555.0, "length": 847, "protein_name": "G-protein coupled receptors family 3 profile domain-containing protein", "gene_name": "Vom2r-ps116", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vom2r-ps116; Vmn2r16", "gene_names_refseq": "", "protein_names_uniprotkb": "G-protein coupled receptors family 3 profile domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GKT6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GL37-1", "uniprot_id": [ { "id": "A0A8I6GL37_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GL37", "type": "external" } ], "mass": 58403.0, "length": 519, "protein_name": "Cerebellar degeneration-related protein 2", "gene_name": "Cdr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cerebellar degeneration-related protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001775 cell activation;GO:0002287 alpha-beta T cell activation involved in immune response;GO:0002870 T cell anergy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GL37-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GLB8-1", "uniprot_id": [ { "id": "A0A8I6GLB8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GLB8", "type": "external" } ], "mass": 21882.0, "length": 198, "protein_name": "Charged multivesicular body protein 1A", "gene_name": "Chmp1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chmp1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Charged multivesicular body protein 1A", "protein_names_refseq": "", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 8 (Disease Ontology:DOID:0060277)", "pathway": " (rno:365024)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0000421 autophagosome membrane;GO:0000794 condensed nuclear chromosome;GO:0005643 nuclear pore", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GLB8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GLR6-1", "uniprot_id": [ { "id": "A0A8I6GLR6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GLR6", "type": "external" } ], "mass": 184677.0, "length": 1646, "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "gene_name": "Prex1", "organism": "Rat", "refseq_name": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "refseq_ac": [ { "id": "NP_001129190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129190", "type": "external" } ], "gene_names_uniprotkb": "Prex1", "gene_names_refseq": "Prex1; RGD1306534", "protein_names_uniprotkb": "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "protein_names_refseq": "phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:311647); (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013409); (R-RNO-9013423)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "18697831;22673903;29393594;33347743", "class_list": "", "function": "Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils., [UniProtKB, UniProtKB, UniProtKB]; P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic beta-Cells., [RefSeq, PubMed]; This study has identified P-Rex1 as a Rac3-guanine nucleotide exchange factor in neuronal cells that localises to, and regulates, actin cytoskeletal dynamics at the axonal growth cone to in turn regulate neurite differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0043198 dendritic shaft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I6GLR6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GLU8-1", "uniprot_id": [ { "id": "A0A8I6GLU8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GLU8", "type": "external" } ], "mass": 44518.0, "length": 414, "protein_name": "TAR DNA-binding protein 43", "gene_name": "Tardbp", "organism": "Rat", "refseq_name": "TAR DNA-binding protein 43 isoform 1", "refseq_ac": [ { "id": "NP_001386034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386034", "type": "external" } ], "gene_names_uniprotkb": "Tardbp", "gene_names_refseq": "Tardbp; Tdp-43", "protein_names_uniprotkb": "TAR DNA-binding protein 43", "protein_names_refseq": "TAR DNA-binding protein 43 isoform 1; TAR DNA-binding protein 43", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); amyotrophic lateral sclerosis type 10 (Disease Ontology:DOID:0060201); frontotemporal dementia 2 (Disease Ontology:DOID:0060672); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Lewy body dementia (Disease Ontology:DOID:12217); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); progressive supranuclear palsy (Disease Ontology:DOID:678); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "32265469;37000196;38235539;38761845", "class_list": "", "function": "Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca(2+) signaling and dysregulated cell metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD., [RefSeq, PubMed]; Inactivation of cGAS signaling pathway mediated by TDP-43 deficiency protects microglia from hypoxia/reoxygenation induced injury., [RefSeq, PubMed]; TDP-43 was Involved in Radiation-induced Neuronal Damage and May Not Through the BDNF/TrkB Pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0010629 negative regulation of gene expression;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I6GLU8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GM73-1", "uniprot_id": [ { "id": "A0A8I6GM73_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GM73", "type": "external" } ], "mass": 97023.0, "length": 855, "protein_name": "Oxysterol-binding protein", "gene_name": "Osbpl3", "organism": "Rat", "refseq_name": "oxysterol-binding protein-related protein 3 isoform X2", "refseq_ac": [ { "id": "XP_008761156", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008761156", "type": "external" } ], "gene_names_uniprotkb": "Osbpl3", "gene_names_refseq": "Osbpl3; RGD1564287", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 3 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:362360); (R-RNO-192105)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Lipid transfer protein that mediates the non-vesicular transport of phosphoinositide 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), or PI(4)P) at the plasma membrane (PM)/ endoplasmic reticulum (ER) contact sites. Extracts PI4P from the PM, in exchange for phosphatidylcholine. Can bind to the ER membrane protein VAPA and recruit VAPA to PM sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120015 sterol transfer activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GM73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GM98-1", "uniprot_id": [ { "id": "A0A8I6GM98_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GM98", "type": "external" } ], "mass": 41246.0, "length": 360, "protein_name": "TDPOZ2", "gene_name": "LOC134485753", "organism": "Rat", "refseq_name": "TD and POZ domain-containing protein 5-like", "refseq_ac": [ { "id": "XP_063138849", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063138849", "type": "external" } ], "gene_names_uniprotkb": "LOC134485753", "gene_names_refseq": "LOC134485753", "protein_names_uniprotkb": "TDPOZ2", "protein_names_refseq": "TD and POZ domain-containing protein 5-like", "tax_id": 10116, "disease": "", "pathway": " (rno:134485753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GM98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8L2QWT0-1", "uniprot_id": [ { "id": "A0A8L2QWT0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8L2QWT0", "type": "external" } ], "mass": 35693.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or1e1fl1", "organism": "Rat", "refseq_name": "olfactory receptor-like protein DTMT", "refseq_ac": [ { "id": "XP_003750902", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003750902", "type": "external" } ], "gene_names_uniprotkb": "Or1e1fl1; LOC687896", "gene_names_refseq": "Or1e1fl1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor-like protein DTMT", "tax_id": 10116, "disease": "", "pathway": " (rno:687896)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8L2QWT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ46-1", "uniprot_id": [ { "id": "B2RZ46_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ46", "type": "external" } ], "mass": 23358.0, "length": 213, "protein_name": "Ras-related protein Rab-17", "gene_name": "Rab17", "organism": "Rat", "refseq_name": "ras-related protein Rab-17", "refseq_ac": [ { "id": "NP_001102833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102833", "type": "external" } ], "gene_names_uniprotkb": "Rab17", "gene_names_refseq": "RGD1562478; Rab17", "protein_names_uniprotkb": "Ras-related protein Rab-17; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-17", "tax_id": 10116, "disease": "", "pathway": " (rno:503269); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24895134;30256711", "class_list": "", "function": "Authors determined that transcytosis of three classes of newly synthesized apical residents showed similar responses to rab17 mutant expression, indicating that rab17 is a general component of the transcytotic machinery required for apically destined vesicle docking and fusion., [RefSeq, PubMed]; These data suggest that Rab17 mediates the dendritic trafficking of Syntaxin-4 to selectively regulate dendritic surface insertion of GluK2-containing KARs in rat hippocampal neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JTD9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0006886 intracellular protein transport;GO:0046847 filopodium assembly;GO:0060271 cilium assembly;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RZ46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EK02-1", "uniprot_id": [ { "id": "F7EK02_RAT", "url": "https://www.uniprot.org/uniprot/F7EK02", "type": "external" } ], "mass": 30995.0, "length": 283, "protein_name": "Mucin 15, cell surface associated", "gene_name": "Muc15", "organism": "Rat", "refseq_name": "mucin-15 isoform X2", "refseq_ac": [ { "id": "XP_038961817", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038961817", "type": "external" } ], "gene_names_uniprotkb": "Muc15", "gene_names_refseq": "Muc15", "protein_names_uniprotkb": "Mucin 15, cell surface associated", "protein_names_refseq": "mucin-15 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-913709); (R-RNO-977068)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, 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"url": "https://www.uniprot.org/uniprot/F7EM91", "type": "external" } ], "mass": 28099.0, "length": 254, "protein_name": "Elongation factor 1 beta central acidic region eukaryote domain-containing protein", "gene_name": "AABR07006688.2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07006688.2", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation factor 1 beta central acidic region eukaryote domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0032991 protein-containing complex;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F2U9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F3E6-1", "uniprot_id": [ { "id": "F7F3E6_RAT", "url": "https://www.uniprot.org/uniprot/F7F3E6", "type": "external" } ], "mass": 113981.0, "length": 1027, "protein_name": "LLGL scribble cell polarity complex component 2", "gene_name": "Llgl2", "organism": "Rat", "refseq_name": "LLGL scribble cell polarity complex component 2 isoform X5", "refseq_ac": [ { "id": "XP_006247790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006247790", "type": "external" } ], 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Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. 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serine/arginine repetitive matrix protein 1 isoform 1; serine/arginine repetitive matrix protein 1", "tax_id": 10116, "disease": "gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (R-RNO-159236); (R-RNO-72163); (R-RNO-9013418); (R-RNO-9013422)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071018 U12-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7FND9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9H2-1", "uniprot_id": [ { "id": "G3V9H2_RAT", "url": "https://www.uniprot.org/uniprot/G3V9H2", "type": "external" } ], "mass": 43047.0, "length": 390, "protein_name": "Coxsackie virus and adenovirus receptor-like 1", "gene_name": "Cxadrl1", "organism": "Rat", "refseq_name": "coxsackie virus and adenovirus receptor-like 1 precursor", "refseq_ac": [ { "id": "NP_955438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955438", "type": "external" } ], "gene_names_uniprotkb": "Cxadrl1", "gene_names_refseq": "Cxadrl1", "protein_names_uniprotkb": "Coxsackie virus and adenovirus receptor-like 1", "protein_names_refseq": "coxsackie virus and adenovirus receptor-like 1 precursor; coxsackievirus and adenovirus receptor homolog; coxsackievirus and adenovirus receptor-like", "tax_id": 10116, "disease": "", "pathway": " (rno:361873)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7H4-1", "uniprot_id": [ { "id": "M0R7H4_RAT", "url": "https://www.uniprot.org/uniprot/M0R7H4", "type": "external" } ], "mass": 16086.0, "length": 137, "protein_name": "KH homology domain-containing protein 1-like", "gene_name": "LOC134483627", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC134483627", "gene_names_refseq": "", "protein_names_uniprotkb": "KH homology domain-containing protein 1-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R7H4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RB77-1", "uniprot_id": [ { "id": "M0RB77_RAT", "url": "https://www.uniprot.org/uniprot/M0RB77", "type": "external" } ], "mass": 16538.0, "length": 145, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000064846", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000064846", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042101 T cell receptor complex;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RB77-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MGB1-1", "uniprot_id": [ { "id": "Q6MGB1_RAT", "url": "https://www.uniprot.org/uniprot/Q6MGB1", "type": "external" } ], "mass": 28562.0, "length": 254, "protein_name": "RT1 class II, locus Ha", "gene_name": "RT1-Ha", "organism": "Rat", "refseq_name": "RT1 class II, locus Ha precursor", "refseq_ac": [ { "id": "NP_001008848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008848", "type": "external" } ], "gene_names_uniprotkb": "RT1-Ha; AABR07044416.1", "gene_names_refseq": "RT1-Ha; RT1.Ha", "protein_names_uniprotkb": "RT1 class II, locus Ha", "protein_names_refseq": "HLA class II histocompatibility antigen, DP alpha 1 chain-like; RLA class II histocompatibility antigen, DP alpha-1 chain-like; RT1 class II, locus Ha precursor; major histocompatibility complex class II H-alpha", "tax_id": 10116, "disease": "onchocerciasis (Disease Ontology:DOID:11678); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); Crohn's disease (Disease Ontology:DOID:8778); allergic asthma (Disease Ontology:DOID:9415); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24986); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-2132295); (R-RNO-389948)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7FN89", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0009986 cell surface;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0032729 positive regulation of type II interferon production;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6MGB1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JU60-1", "uniprot_id": [ { "id": "A0A0G2JU60_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JU60", "type": "external" } ], "mass": 57401.0, "length": 534, "protein_name": "Glucocorticoid-induced transcript 1 protein", "gene_name": "Glcci1; Umad1", "organism": "Rat", "refseq_name": "glucocorticoid-induced transcript 1 protein isoform 1", "refseq_ac": [ { "id": "NP_001426836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426836", "type": "external" } ], "gene_names_uniprotkb": "Glcci1; Umad1; Glcci1", "gene_names_refseq": "Glcci1; RGD1563612", "protein_names_uniprotkb": "Glucocorticoid-induced transcript 1 protein", "protein_names_refseq": "glucocorticoid induced transcript 1; glucocorticoid-induced transcript 1 protein isoform 1; glucocorticoid-induced transcript 1 protein", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;27174202", "class_list": "", "function": "GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098846 podocyte foot", "go_biological_process": "GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JU60-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JV50-1", "uniprot_id": [ { "id": "A0A0G2JV50_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JV50", "type": "external" } ], "mass": 58813.0, "length": 536, "protein_name": "Family with sequence similarity 124 member A", "gene_name": "Fam124a", "organism": "Rat", "refseq_name": "family with sequence similarity 124 member A", "refseq_ac": [ { "id": "NP_001420030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420030", "type": "external" } ], "gene_names_uniprotkb": "Fam124a", "gene_names_refseq": "Fam124a", "protein_names_uniprotkb": "Family with sequence similarity 124 member A", "protein_names_refseq": "family with sequence similarity 124 member A; family with sequence similarity 124A; rCG52099-like", "tax_id": 10116, "disease": "", "pathway": " (rno:691938)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JV50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JYV2-1", "uniprot_id": [ { "id": "A0A0G2JYV2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JYV2", "type": "external" } ], "mass": 165701.0, "length": 1484, "protein_name": "Cleavage and polyadenylation specificity factor subunit 1", "gene_name": "Cpsf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cpsf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 1; Cleavage and polyadenylation specificity factor 160 kDa subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "myopia (Disease Ontology:DOID:11830)", "pathway": " (R-RNO-159231); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. 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0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0035925 mRNA 3'-UTR AU-rich region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JYV2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZR6-1", "uniprot_id": [ { "id": "A0A0G2JZR6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZR6", "type": "external" } ], "mass": 65964.0, "length": 598, "protein_name": "GATA zinc 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RGD1563517", "protein_names_uniprotkb": "C-type lectin domain family 1, member B", "protein_names_refseq": "C-type lectin domain family 1 member B isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:500336); (R-RNO-114604); (R-RNO-9707616)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007165 signal transduction;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GBW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5YBG7-1", "uniprot_id": [ { "id": "A0A8I5YBG7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG7", "type": "external" } ], "mass": 30105.0, "length": 275, "protein_name": "Pyridoxal phosphate homeostasis protein", "gene_name": "Plpbp", "organism": "Rat", "refseq_name": "pyridoxal phosphate homeostasis protein", "refseq_ac": [ { "id": "NP_001100790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100790", "type": "external" } ], "gene_names_uniprotkb": "Plpbp; PROSC; Prosc", "gene_names_refseq": "Plpbp; Prosc", "protein_names_uniprotkb": "Pyridoxal phosphate homeostasis protein; PLP homeostasis protein; Proline synthase co-transcribed bacterial homolog protein", "protein_names_refseq": "proline synthase co-transcribed bacterial homolog protein; proline synthetase co-transcribed homolog; pyridoxal phosphate homeostasis protein", "tax_id": 10116, "disease": "early-onset vitamin B6-dependent epilepsy 1 (Disease Ontology:DOID:0080769)", "pathway": " (rno:306544)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042816 vitamin B6 metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5YBG7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZMK5-1", "uniprot_id": [ { "id": "A0A8I5ZMK5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMK5", "type": "external" } ], "mass": 240221.0, "length": 2171, "protein_name": "ARFGEF family member 3", "gene_name": "Arfgef3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arfgef3; RGD1309903", "gene_names_refseq": "", "protein_names_uniprotkb": "ARFGEF family member 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0032012 regulation of ARF protein signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZMK5-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y786-1", "uniprot_id": [ { "id": "A0A8I5Y786_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y786", "type": "external" } ], "mass": 68732.0, "length": 611, "protein_name": "Ankyrin repeat and SOCS box containing 15", "gene_name": "Asb15", "organism": "Rat", "refseq_name": "ankyrin repeat and SOCS box protein 15 isoform X1", "refseq_ac": [ { "id": "XP_038964544", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038964544", "type": "external" } ], "gene_names_uniprotkb": "Asb15", "gene_names_refseq": "Asb15", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box containing 15", "protein_names_refseq": "ankyrin repeat and SOCS box protein 15 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y786-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6APF4-1", "uniprot_id": [ { "id": "A0A8I6APF4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6APF4", "type": "external" } ], "mass": 64743.0, "length": 590, "protein_name": "Tumor protein p73", "gene_name": "Tp73", "organism": "Rat", "refseq_name": "tumor protein p73 isoform X2", "refseq_ac": [ { "id": "XP_038966383", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038966383", "type": "external" } ], "gene_names_uniprotkb": "Tp73", "gene_names_refseq": "P73; Tp73; Trp73", "protein_names_uniprotkb": "Tumor protein p73", "protein_names_refseq": "tumor protein p73 isoform X2", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:362675); (R-RNO-6804759); (R-RNO-8939236)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression., [UniProtKB, UniProtKB, UniProtKB]; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005886 plasma membrane", "go_biological_process": "GO:1901248 positive regulation of lung ciliated cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6APF4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AFM1-1", "uniprot_id": [ { "id": "A0A8I6AFM1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AFM1", "type": "external" } ], "mass": 101417.0, "length": 887, "protein_name": "Coiled-coil domain containing 110", "gene_name": "Ccdc110", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccdc110", "gene_names_refseq": "", "protein_names_uniprotkb": "Coiled-coil domain containing 110", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:290755)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AFM1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G2R1-1", "uniprot_id": [ { "id": "A0A8I6G2R1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G2R1", "type": "external" } ], "mass": 79273.0, "length": 704, "protein_name": "Beta-transducin repeat containing E3 ubiquitin protein ligase", "gene_name": "Btrc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Btrc", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-transducin repeat containing E3 ubiquitin protein ligase", "protein_names_refseq": "", "tax_id": 10116, "disease": "Menkes disease (Disease Ontology:DOID:1838)", "pathway": " (rno:361765); (R-RNO-1169091); (R-RNO-1170546); (R-RNO-174113); (R-RNO-195253); (R-RNO-202424); (R-RNO-2565942); (R-RNO-2871837); (R-RNO-3769402); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-69601); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9762114); (R-RNO-983168); (R-RNO-9929356)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0008013 beta-catenin binding;GO:0045309 protein phosphorylated amino acid binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0070936 protein K48-linked ubiquitination;GO:0038061 non-canonical NF-kappaB signal transduction;GO:0050860 negative regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6G2R1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AGX8-1", "uniprot_id": [ { "id": "A0A8I6AGX8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AGX8", "type": "external" } ], "mass": 162997.0, "length": 1458, "protein_name": "FA complementation group A", "gene_name": "Fanca", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fanca", "gene_names_refseq": "", "protein_names_uniprotkb": "FA complementation group A", "protein_names_refseq": "", "tax_id": 10116, "disease": "Fanconi anemia complementation group A (Disease Ontology:DOID:0111095); urinary bladder cancer (Disease Ontology:DOID:11054); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cervical cancer (Disease Ontology:DOID:4362); primary ovarian insufficiency (Disease Ontology:DOID:5426); skin melanoma (Disease Ontology:DOID:8923); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-RNO-6783310); (R-RNO-9833482)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0036297 interstrand cross-link repair;GO:2000348 regulation of CD40 signaling pathway;GO:0042127 regulation of cell population proliferation;GO:0008584 male gonad development;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AGX8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZZE0-1", "uniprot_id": [ { "id": "A0A8I5ZZE0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZE0", "type": "external" } ], "mass": 202825.0, "length": 1799, "protein_name": "Bromodomain and WD repeat-containing protein 3", "gene_name": "Brwd3", "organism": "Rat", "refseq_name": "bromodomain and WD repeat-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_008771579", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008771579", "type": "external" } ], "gene_names_uniprotkb": "Brwd3", "gene_names_refseq": "Brwd3", "protein_names_uniprotkb": "Bromodomain and WD repeat-containing protein 3", "protein_names_refseq": "bromodomain and WD repeat-containing protein 3 isoform X1", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 93 (Disease Ontology:DOID:0112045)", "pathway": " (rno:317213)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZZE0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AEJ0-1", "uniprot_id": [ { "id": "A0A8I6AEJ0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AEJ0", "type": "external" } ], "mass": 59592.0, "length": 529, "protein_name": "tRNA splicing endonuclease subunit 54", "gene_name": "Tsen54", "organism": "Rat", "refseq_name": "tRNA-splicing endonuclease subunit Sen54 isoform X4", "refseq_ac": [ { "id": "XP_038942804", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038942804", "type": "external" } ], "gene_names_uniprotkb": "Tsen54", "gene_names_refseq": "Tsen54", "protein_names_uniprotkb": "tRNA splicing endonuclease subunit 54", "protein_names_refseq": "tRNA-splicing endonuclease subunit Sen54 isoform X4", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 2A (Disease Ontology:DOID:0060267); pontocerebellar hypoplasia type 4 (Disease Ontology:DOID:0060273); pontocerebellar hypoplasia type 5 (Disease Ontology:DOID:0060274)", "pathway": " (rno:690308)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AEJ0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A829-1", "uniprot_id": [ { "id": "A0A8I6A829_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A829", "type": "external" } ], "mass": 239498.0, "length": 2102, "protein_name": "Dedicator of cytokinesis 8", "gene_name": "Dock8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dock8", "gene_names_refseq": "", "protein_names_uniprotkb": "Dedicator of cytokinesis 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "hyper IgE recurrent infection syndrome 2 (Disease Ontology:DOID:0080594); immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (Disease Ontology:DOID:0090110); bacterial infectious disease (Disease Ontology:DOID:104); hepatitis B (Disease Ontology:DOID:2043); atopic dermatitis (Disease Ontology:DOID:3310); viral infectious disease (Disease Ontology:DOID:934); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:499337); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013409); (R-RNO-983231)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031252 cell leading edge;GO:0031256 leading edge membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0061485 memory T cell proliferation;GO:1903905 positive regulation of establishment of T cell polarity;GO:1990869 cellular response to chemokine;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A829-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8J8YGA4-1", "uniprot_id": [ { "id": "A0A8J8YGA4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8J8YGA4", "type": "external" } ], "mass": 94708.0, "length": 848, "protein_name": "phosphatidate phosphatase", "gene_name": "Lpin3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lpin3", "gene_names_refseq": "", "protein_names_uniprotkb": "phosphatidate phosphatase; 3.1.3.4", "protein_names_refseq": "", "tax_id": 10116, "disease": "myoglobinuria (Disease Ontology:DOID:0080108); lipid metabolism disorder (Disease Ontology:DOID:3146); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-1483191); (R-RNO-1483213); (R-RNO-4419969); (R-RNO-75109)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8J8YGA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GGV9-1", "uniprot_id": [ { "id": "A0A8I6GGV9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GGV9", "type": "external" } ], "mass": 127248.0, "length": 1164, "protein_name": "ALF transcription elongation factor 4", "gene_name": "Aff4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aff4", "gene_names_refseq": "", "protein_names_uniprotkb": "ALF transcription elongation factor 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:303132); (R-RNO-112382); (R-RNO-674695); (R-RNO-75955)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0001650 fibrillar center;GO:0016604 nuclear body", "go_biological_process": "GO:0007286 spermatid development;GO:0010468 regulation of gene expression;GO:0034976 response to endoplasmic reticulum stress;GO:0006355 regulation of DNA-templated transcription;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GGV9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GH40-1", "uniprot_id": [ { "id": "A0A8I6GH40_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GH40", "type": "external" } ], "mass": 69832.0, "length": 628, "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "Eif2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eif2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2A; eIF-2A", "protein_names_refseq": "", "tax_id": 10116, "disease": "borna disease (Disease Ontology:DOID:5154)", "pathway": " (rno:502531)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0006468 protein phosphorylation;GO:0006413 translational initiation;GO:0006412 translation;GO:1990928 response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GH40-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G4R8-1", "uniprot_id": [ { "id": "A0A8I6G4R8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G4R8", "type": "external" } ], "mass": 121195.0, "length": 1114, "protein_name": "Histone deacetylase", "gene_name": "Hdac5", "organism": "Rat", "refseq_name": "histone deacetylase 5 isoform X2", "refseq_ac": [ { "id": "XP_038942912", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038942912", "type": "external" } ], "gene_names_uniprotkb": "Hdac5", "gene_names_refseq": "Hdac5", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "histone deacetylase 5 isoform X2", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-350054)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010830 regulation of myotube differentiation;GO:2000648 positive regulation of stem cell proliferation;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6G4R8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AM63-1", "uniprot_id": [ { "id": "A0A8I6AM63_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AM63", "type": "external" } ], "mass": 238877.0, "length": 2155, "protein_name": "Synaptotagmin-like protein 2", "gene_name": "Sytl2", "organism": "Rat", "refseq_name": "synaptotagmin-like protein 2", "refseq_ac": [ { "id": "NP_001101962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101962", "type": "external" } ], "gene_names_uniprotkb": "Sytl2", "gene_names_refseq": "Sytl2", "protein_names_uniprotkb": "Synaptotagmin-like protein 2; 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long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:100363276); (R-RNO-8980692); (R-RNO-9013423)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0016004 phospholipase activator activity;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007165 signal transduction;GO:1902533 positive regulation of intracellular signal transduction;GO:0007015 actin filament organization;GO:0048041 focal adhesion assembly;GO:0051895 negative regulation of focal adhesion assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AAE4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A6W3-1", "uniprot_id": [ { "id": "A0A8I6A6W3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A6W3", "type": "external" } ], "mass": 45830.0, "length": 398, "protein_name": "LIM and senescent cell antigen-like-containing domain protein", "gene_name": "Lims1", "organism": "Rat", "refseq_name": "LIM and senescent cell antigen-like-containing domain protein 1 isoform X2", "refseq_ac": [ { "id": "XP_006256447", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256447", "type": "external" } ], "gene_names_uniprotkb": "Lims1", "gene_names_refseq": "Lims1; 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Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A9V6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GLX4-1", "uniprot_id": [ { "id": "A0A8I6GLX4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GLX4", "type": "external" } ], "mass": 214938.0, "length": 1925, "protein_name": "Disks large homolog 5", "gene_name": "Dlg5", "organism": "Rat", "refseq_name": "disks large homolog 5", "refseq_ac": [ { "id": "NP_001358932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001358932", "type": "external" } ], "gene_names_uniprotkb": "Dlg5", "gene_names_refseq": "Dlg5", "protein_names_uniprotkb": "Disks large homolog 5", "protein_names_refseq": "discs, large homolog 5; 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3.2.2.-", "protein_names_refseq": "methyl-CpG-binding domain protein 4", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); lung cancer (Disease Ontology:DOID:1324); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); uveal melanoma (Disease Ontology:DOID:6039); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (R-RNO-110329); (R-RNO-110357)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0032355 response to estradiol;GO:0009314 response to radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AH85-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GH74-1", "uniprot_id": [ { "id": "A0A8I6GH74_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GH74", "type": "external" } ], "mass": 48015.0, "length": 416, "protein_name": "ARB2 cotranscriptional regulator A", "gene_name": "Arb2a", "organism": "Rat", "refseq_name": "cotranscriptional regulator ARB2A isoform 3", "refseq_ac": [ { "id": "NP_001426416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426416", "type": "external" } ], "gene_names_uniprotkb": "Arb2a; Fam172a", "gene_names_refseq": "Arb2a; Fam172a; RGD1305526", "protein_names_uniprotkb": "ARB2 cotranscriptional regulator A", "protein_names_refseq": "cotranscriptional regulator ARB2A isoform 3; cotranscriptional regulator ARB2A; cotranscriptional regulator FAM172A; family with sequence similarity 172, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:294606)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0031048 regulatory ncRNA-mediated heterochromatin formation;GO:0014032 neural crest cell development;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GH74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZYQ6-1", "uniprot_id": [ { "id": "A0A8I5ZYQ6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYQ6", "type": "external" } ], "mass": 303171.0, "length": 2702, "protein_name": "Senataxin", "gene_name": "Setx", "organism": "Rat", "refseq_name": "probable helicase senataxin isoform X1", "refseq_ac": [ { "id": "XP_006233948", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233948", "type": "external" } ], "gene_names_uniprotkb": "Setx", "gene_names_refseq": "RGD1565575; Setx", "protein_names_uniprotkb": "Senataxin", "protein_names_refseq": "probable helicase senataxin isoform X1", "tax_id": 10116, "disease": "spinocerebellar ataxia with axonal neuropathy 2 (Disease Ontology:DOID:0050755); amyotrophic lateral sclerosis type 4 (Disease Ontology:DOID:0060196)", "pathway": " (rno:362096)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0004386 helicase activity;GO:0033677 DNA/RNA helicase activity;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0001147 transcription termination site sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0010976 positive regulation of neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I5ZYQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A2K9-1", "uniprot_id": [ { "id": "A0A8I6A2K9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A2K9", "type": "external" } ], "mass": 28312.0, "length": 246, "protein_name": "HscB mitochondrial iron-sulfur cluster co-chaperone", "gene_name": "Hscb", "organism": "Rat", "refseq_name": "iron-sulfur cluster co-chaperone protein HscB isoform X1", "refseq_ac": [ { "id": "XP_008767562", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008767562", "type": "external" } ], "gene_names_uniprotkb": "Hscb", "gene_names_refseq": "Hscb; RGD1311005", "protein_names_uniprotkb": "HscB mitochondrial iron-sulfur cluster co-chaperone", "protein_names_refseq": "iron-sulfur cluster co-chaperone protein HscB isoform X1", "tax_id": 10116, "disease": "sideroblastic anemia 5 (Disease Ontology:DOID:0061007)", "pathway": " (rno:360826); (R-RNO-1268020); (R-RNO-1362409); (R-RNO-6799198); (R-RNO-9865881)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Plays an essential role in hematopoiesis., [UniProtKB, UniProtKB]; Acts as a co-chaperone in iron-sulfur cluster assembly in the cytoplasm. Also mediates complex formation between components of the cytosolic iron-sulfur biogenesis pathway and the CIA targeting complex composed of CIAO1, DIPK1B/FAM69B and MMS19 by binding directly to the scaffold protein ISCU and to CIAO1. This facilitates iron-sulfur cluster insertion into a number of cytoplasmic and nuclear proteins including POLD1, ELP3, DPYD and PPAT., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0001671 ATPase activator activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0044571 [2Fe-2S] cluster assembly;GO:0016226 iron-sulfur cluster assembly;GO:0060319 primitive erythrocyte differentiation;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A2K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZYP3-1", "uniprot_id": [ { "id": "A0A8I5ZYP3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYP3", "type": "external" } ], "mass": 276545.0, "length": 2448, "protein_name": "Testis expressed gene 16", "gene_name": "Tex16", "organism": "Rat", "refseq_name": "testis expressed gene 16-like isoform 1", "refseq_ac": [ { "id": "NP_001404216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001404216", "type": "external" } ], "gene_names_uniprotkb": "Tex16", "gene_names_refseq": "Tex16", "protein_names_uniprotkb": "Testis expressed gene 16", "protein_names_refseq": "testis expressed gene 16-like isoform 1; testis expressed gene 16-like", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "", "go_biological_process": "GO:0007167 enzyme-linked receptor protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZYP3-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A054-1", "uniprot_id": [ { "id": "A0A8I6A054_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A054", "type": "external" } ], "mass": 56714.0, "length": 538, "protein_name": "Zinc finger protein AEBP2", "gene_name": "Aebp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aebp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein AEBP2; Adipocyte enhancer-binding protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:297705); (R-RNO-212300); (R-RNO-3214841)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. 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0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0048188 Set1C/COMPASS complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6ANV4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ABZ6-1", "uniprot_id": [ { "id": "A0A8I6ABZ6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ6", "type": "external" } ], "mass": 19740.0, "length": 181, "protein_name": "Sterile alpha motif domain-containing protein 5", "gene_name": "Samd5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Samd5", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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"synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ABZ6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AC62-1", "uniprot_id": [ { "id": "A0A8I6AC62_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AC62", "type": "external" } ], "mass": 62548.0, "length": 563, "protein_name": "Solute carrier family 43 member 1", "gene_name": "Slc43a1", "organism": "Rat", "refseq_name": "large neutral amino acids transporter small subunit 3 isoform X2", "refseq_ac": [ { "id": "XP_038960809", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038960809", "type": "external" } ], "gene_names_uniprotkb": "Slc43a1", "gene_names_refseq": "Slc43a1", "protein_names_uniprotkb": "Solute carrier family 43 member 1", "protein_names_refseq": "large neutral amino acids transporter small subunit 3 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:311168); (R-RNO-352230)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015190 L-leucine transmembrane transporter activity;GO:0005304 L-valine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0098846 podocyte foot", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015804 neutral amino acid transport;GO:0015807 L-amino acid transport;GO:0051956 negative regulation of amino acid transport;GO:0015818 isoleucine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AC62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AC66-1", "uniprot_id": [ { "id": "A0A8I6AC66_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AC66", "type": "external" } ], "mass": 26571.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "Eif6-ps1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eif6-ps1; EIF6; ITGB4BP", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; eIF-6", "protein_names_refseq": "", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0000054 ribosomal subunit export from nucleus;GO:0000460 maturation of 5.8S rRNA;GO:0042256 cytosolic ribosome assembly;GO:0000470 maturation of LSU-rRNA;GO:1902626 assembly of large subunit precursor of preribosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AC66-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ACE8-1", "uniprot_id": [ { "id": "A0A8I6ACE8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ACE8", "type": "external" } ], "mass": 57333.0, "length": 509, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LOC100910657; Smokyl-ps1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC100910657; Smokyl-ps1; LOC134482751; LOC134482841; LOC134485014; LOC134485019; LOC134485067; LOC134485068; LOC134485070; LOC134485076; LOC134485084; LOC134485089; LOC134485090; LOC134485091; Smokyl-ps1", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:120098099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, 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In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body;GO:0005886 plasma membrane", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0001765 membrane raft assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AJ79-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AJS5-1", "uniprot_id": [ { "id": "A0A8I6AJS5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AJS5", "type": "external" } ], "mass": 140027.0, "length": 1309, "protein_name": "Rho GTPase-activating protein 33", "gene_name": "Arhgap33", "organism": "Rat", "refseq_name": "Rho GTPase activating protein 33 isoform a", "refseq_ac": [ { "id": "NP_001419669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419669", "type": "external" } ], "gene_names_uniprotkb": "Arhgap33", "gene_names_refseq": "Arhgap33; Snx26", "protein_names_uniprotkb": "Rho GTPase-activating protein 33; Rho-type GTPase-activating protein 33; Sorting nexin-26; Tc10/CDC42 GTPase-activating protein", "protein_names_refseq": "Rho GTPase activating protein 33 isoform a", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013406)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0009636 response to toxic substance;GO:0061001 regulation of dendritic spine morphogenesis;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AJS5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AK73-1", "uniprot_id": [ { "id": "A0A8I6AK73_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AK73", "type": "external" } ], "mass": 20970.0, "length": 187, "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "ENSRNOG00000065084", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000065084", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase; 5.2.1.8; PPIase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000063713", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000063713", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-173623); (R-RNO-198933); (R-RNO-202733); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2168880); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5690714); (R-RNO-977606); (R-RNO-983695)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AKH5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AKP4-1", "uniprot_id": [ { "id": "A0A8I6AKP4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AKP4", "type": "external" } ], "mass": 10123.0, "length": 87, "protein_name": "Immunoglobulin V-set domain-containing protein", "gene_name": "ENSRNOG00000068912", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000068912", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin V-set domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, 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"glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AKP4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AL26-1", "uniprot_id": [ { "id": "A0A8I6AL26_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AL26", "type": "external" } ], "mass": 73348.0, "length": 678, "protein_name": "Growth arrest-specific 2 like 3", "gene_name": "Gas2l3", "organism": "Rat", "refseq_name": "GAS2-like protein 3", "refseq_ac": [ { "id": "NP_001418949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418949", "type": "external" } ], "gene_names_uniprotkb": "Gas2l3", "gene_names_refseq": "Gas2l3", "protein_names_uniprotkb": "Growth arrest-specific 2 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"A0A8I6ALK3-1", "uniprot_id": [ { "id": "A0A8I6ALK3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALK3", "type": "external" } ], "mass": 98585.0, "length": 863, "protein_name": "Pre-mRNA-processing factor 40 homolog B", "gene_name": "Prpf40b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prpf40b", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-mRNA-processing factor 40 homolog B; Huntingtin yeast partner C; Huntingtin-interacting protein C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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nucleus;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0005685 U1 snRNP;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0045292 mRNA cis splicing, via spliceosome;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6ALK3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AM39-1", "uniprot_id": [ { "id": "A0A8I6AM39_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AM39", "type": "external" } ], "mass": 114881.0, "length": 1038, "protein_name": "Bone morphogenetic protein receptor type-2", "gene_name": "Bmpr2", "organism": "Rat", "refseq_name": "bone morphogenetic protein receptor type-2 precursor", "refseq_ac": [ { "id": "NP_536332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536332", "type": "external" } ], "gene_names_uniprotkb": "Bmpr2", "gene_names_refseq": "Bmpr-II; Bmpr2", "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-2; 2.7.11.30; Bone morphogenetic protein receptor type II", "protein_names_refseq": "bone morphogenetic protein receptor type II; bone morphogenetic protein receptor type-2 precursor; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase)", "tax_id": 10116, "disease": "pulmonary venoocclusive disease 1 (Disease Ontology:DOID:0081268); primary pulmonary hypertension (Disease Ontology:DOID:14557); heart septal defect (Disease Ontology:DOID:1681); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:140590); (R-RNO-201451)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;34857612;35037801;35848848;36917778;38979789", "class_list": "", "function": "LncRNA MINCR attenuates osteoarthritis progression via sponging miR-146a-5p to promote BMPR2 expression., [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor beta-induced profibrotic responses in lung fibroblasts., [RefSeq, PubMed]; Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation., [RefSeq, PubMed]; Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes. Publication Status: Online-Only, [RefSeq, PubMed]; Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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gene expression;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A8I6AM39-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ANN9-1", "uniprot_id": [ { "id": "A0A8I6ANN9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ANN9", "type": "external" } ], "mass": 53155.0, "length": 536, "protein_name": "Doublesex- and mab-3-related transcription factor A2", "gene_name": "Dmrta2", "organism": "Rat", "refseq_name": "doublesex- and mab-3-related transcription factor A2", "refseq_ac": [ { "id": "NP_001101421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101421", "type": "external" } ], "gene_names_uniprotkb": "Dmrta2", "gene_names_refseq": "Dmrta2", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related 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cortex regionalization;GO:0035914 skeletal muscle cell differentiation;GO:0048665 neuron fate specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ANN9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6APR7-1", "uniprot_id": [ { "id": "A0A8I6APR7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6APR7", "type": "external" } ], "mass": 65800.0, "length": 595, "protein_name": "ANTXR like 3", "gene_name": "Antxrl3", "organism": "Rat", "refseq_name": "similar to tumor endothelial marker 8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001403907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001403907", "type": "external" } ], "gene_names_uniprotkb": "Antxrl3; LOC681303", "gene_names_refseq": "AABR07024653.1; Antxrl3", "protein_names_uniprotkb": "ANTXR like 3", "protein_names_refseq": "anthrax toxin receptor-like; leucine-rich 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Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031 protein transport;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GES6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GHP4-1", "uniprot_id": [ { "id": "A0A8I6GHP4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GHP4", "type": "external" } ], "mass": 32578.0, "length": 287, "protein_name": "Nuclear receptor-binding factor 2", "gene_name": "Nrbf2l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nrbf2l1; AABR07072761.1; RGD1560263", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor-binding factor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-383280)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation., [UniProtKB, UniProtKB]; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GHP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GHT9-1", "uniprot_id": [ { "id": "A0A8I6GHT9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GHT9", "type": "external" } ], "mass": 125070.0, "length": 1104, "protein_name": "SLIT-ROBO Rho GTPase activating protein 3", "gene_name": "Srgap3", "organism": "Rat", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 3 isoform 3", "refseq_ac": [ { "id": "NP_001430640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001430640", "type": "external" } ], "gene_names_uniprotkb": "Srgap3", "gene_names_refseq": "RGD1563152; Srgap3", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase activating protein 3", "protein_names_refseq": "SLIT-ROBO Rho GTPase-activating protein 3 isoform 3", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:500287); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16641100;17710530;22673903;23311320", "class_list": "", "function": "Results provide strong evidence that srGAP3 is involved in the regulation of biological behavior and the morphological features in neural stem cells/neural progenitor cells in vitro, [RefSeq, PubMed]; Results suggest that srGAPs are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0150052 regulation of postsynapse assembly;GO:0007399 nervous system development;GO:0030336 negative regulation of cell migration;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I6GHT9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GIQ2-1", "uniprot_id": [ { "id": "A0A8I6GIQ2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GIQ2", "type": "external" } ], "mass": 119825.0, "length": 1087, "protein_name": "SECIS binding protein 2-like", "gene_name": "Secisbp2l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Secisbp2l", "gene_names_refseq": "", "protein_names_uniprotkb": "SECIS binding protein 2-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"filter_code": "0000000.0000000.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GKE3-1", "uniprot_id": [ { "id": "A0A8I6GKE3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GKE3", "type": "external" } ], "mass": 14515.0, "length": 132, "protein_name": "Globin domain-containing protein", "gene_name": "ENSRNOG00000070249", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000070249", "gene_names_refseq": "", "protein_names_uniprotkb": "Globin domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, 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"protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A7M0-1", "uniprot_id": [ { "id": "A0A8I6A7M0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A7M0", "type": "external" } ], "mass": 214713.0, "length": 1893, "protein_name": "Transcription initiation factor TFIID subunit", "gene_name": "Taf1", "organism": "Rat", "refseq_name": "transcription initiation factor TFIID subunit 1", "refseq_ac": [ { "id": "NP_001178652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178652", "type": "external" } ], "gene_names_uniprotkb": "Taf1", "gene_names_refseq": "RGD1562050; Taf1", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit", "protein_names_refseq": "TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor; transcription initiation factor TFIID subunit 1-like; transcription initiation factor TFIID subunit 1", "tax_id": 10116, "disease": 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"gene_names_refseq": "Ppp2r5c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4", "tax_id": 10116, "disease": "", "pathway": " (rno:691318)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16603688;17416611;19131648", "class_list": "", "function": "In an established model of sustained JNK activation, a 70% decrease in expression of the targeting subunit of PP2A, B56alpha, was observed in either neonatal or adult cardiomyocytes., [RefSeq, PubMed]; MiR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2., [RefSeq, PubMed]; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a 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"tax_id": 10116, "disease": "sleep disorder (Disease Ontology:DOID:535)", "pathway": " (R-RNO-3232118); (R-RNO-8866904); (R-RNO-8866907); (R-RNO-8866911); (R-RNO-9834899)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021877 forebrain neuron fate commitment;GO:0048733 sebaceous gland development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7EWS2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AFP4-1", "uniprot_id": [ { "id": "A0A8I6AFP4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AFP4", "type": "external" } ], "mass": 37200.0, "length": 334, "protein_name": "E3 ubiquitin-protein ligase RNF144A", "gene_name": "Rnf144a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf144a", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144A; 2.3.2.31; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500636); (R-RNO-8866654)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031090 organelle membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0002221 pattern recognition receptor signaling pathway;GO:0085020 protein K6-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AFP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZVI5-1", "uniprot_id": [ { "id": "A0A8I5ZVI5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVI5", "type": "external" } ], "mass": 56678.0, "length": 515, "protein_name": "Anthrax toxin receptor", "gene_name": "Antxr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Antxr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Anthrax toxin receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "fibroma (Disease Ontology:DOID:0050871); hyaline fibromatosis syndrome (Disease Ontology:DOID:0111669); anthrax disease (Disease Ontology:DOID:7427)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007338 single fertilization;GO:0030199 collagen fibril organization;GO:0060065 uterus development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZVI5-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZUZ1-1", "uniprot_id": [ { "id": "A0A8I5ZUZ1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZUZ1", "type": "external" } ], "mass": 27812.0, "length": 261, "protein_name": "E3 ubiquitin-protein ligase ZNRF1", "gene_name": "Znrf1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase ZNRF1 isoform X1", "refseq_ac": [ { "id": "XP_006255712", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255712", "type": "external" } ], "gene_names_uniprotkb": "Znrf1", "gene_names_refseq": "Znrf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ZNRF1; 2.3.2.27; Nerve injury-induced gene 283 protein; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase ZNRF1 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-983168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0034145 positive regulation of toll-like receptor 4 signaling pathway;GO:0160177 positive regulation of autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZUZ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FAJ9-1", "uniprot_id": [ { "id": "F7FAJ9_RAT", "url": "https://www.uniprot.org/uniprot/F7FAJ9", "type": "external" } ], "mass": 39660.0, "length": 355, "protein_name": "Carbonic anhydrase", "gene_name": "Ca12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ca12; Car12", "gene_names_refseq": "", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); isolated hyperchlorhidrosis (Disease Ontology:DOID:0111371); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); fibrolamellar carcinoma (Disease Ontology:DOID:5015); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-RNO-1475029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0044849 estrous cycle;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FAJ9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A123-1", "uniprot_id": [ { "id": "A0A8I6A123_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A123", "type": "external" } ], "mass": 208941.0, "length": 1884, "protein_name": "Proteasome adapter and scaffold protein ECM29", "gene_name": "Ecpas", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ecpas", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome adapter and scaffold protein ECM29; Proteasome-associated protein ECM29 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0036503 ERAD pathway;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A123-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y571-1", "uniprot_id": [ { "id": "A0A8I5Y571_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y571", "type": "external" } ], "mass": 305638.0, "length": 2731, "protein_name": "Teneurin-1", "gene_name": "Tenm1", "organism": "Rat", "refseq_name": "teneurin-1 isoform X3", "refseq_ac": [ { "id": "XP_038956357", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038956357", "type": "external" } ], "gene_names_uniprotkb": "Tenm1", "gene_names_refseq": "Tenm1", "protein_names_uniprotkb": "Teneurin-1; Protein Odd Oz/ten-m homolog 1; Tenascin-M1; Teneurin transmembrane protein 1", "protein_names_refseq": "teneurin-1 isoform X3", "tax_id": 10116, "disease": "", "pathway": " (rno:298168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Induces gene transcription activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Also acts as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0043005 neuron projection", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007218 neuropeptide signaling pathway;GO:0048666 neuron development;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y571-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZLK5-1", "uniprot_id": [ { "id": "A0A8I5ZLK5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLK5", "type": "external" } ], "mass": 254159.0, "length": 2263, "protein_name": "P-type phospholipid transporter", "gene_name": "Abca1", "organism": "Rat", "refseq_name": "phospholipid-transporting ATPase ABCA1 isoform X1", "refseq_ac": [ { "id": "XP_038965774", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038965774", "type": "external" } ], "gene_names_uniprotkb": "Abca1", "gene_names_refseq": "Abca1", "protein_names_uniprotkb": "P-type phospholipid transporter; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase ABCA1 isoform X1", "tax_id": 10116, "disease": "primary hypoalphalipoproteinemia 1 (Disease Ontology:DOID:0080957); aortic atherosclerosis (Disease Ontology:DOID:10230); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); membranous glomerulonephritis (Disease Ontology:DOID:10976); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); extrahepatic cholestasis (Disease Ontology:DOID:13619); hypolipoproteinemia (Disease Ontology:DOID:1387); Tangier disease (Disease Ontology:DOID:1388); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-8963896); (R-RNO-9029569)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity;GO:0005102 signaling receptor binding;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0016020 membrane;GO:0097708 intracellular vesicle;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8I5ZLK5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F6E7-1", "uniprot_id": [ { "id": "F7F6E7_RAT", "url": "https://www.uniprot.org/uniprot/F7F6E7", "type": "external" } ], "mass": 36902.0, "length": 335, "protein_name": "Apolipoprotein L3 like 1", "gene_name": "LOC120093819", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC120093819; Apol3l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Apolipoprotein L3 like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "kidney disease (Disease Ontology:DOID:557)", "pathway": " (R-RNO-2168880); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006869 lipid transport;GO:0042157 lipoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F6E7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EZM1-1", "uniprot_id": [ { "id": "F7EZM1_RAT", "url": "https://www.uniprot.org/uniprot/F7EZM1", "type": "external" } ], "mass": 16460.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 4C", "gene_name": "Eif1ax", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 1A, X-chromosomal", "refseq_ac": [ { "id": "NP_001100433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100433", "type": "external" } ], "gene_names_uniprotkb": "Eif1ax", "gene_names_refseq": "Eif1ax; Eif1ay; RGD1560198", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4C", "protein_names_refseq": "eukaryotic translation initiation factor 1A, X-chromosomal; eukaryotic translation initiation factor 1A, Y-linked", "tax_id": 10116, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (rno:302697); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0045202 synapse;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7EZM1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZYW3-1", "uniprot_id": [ { "id": "A0A8I5ZYW3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZYW3", "type": "external" } ], "mass": 50217.0, "length": 458, "protein_name": "Lymphocyte-specific protein 1", "gene_name": "Lsp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lsp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lymphocyte-specific protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006935 chemotaxis;GO:0006952 defense response;GO:0098761 cellular response to interleukin-7", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZYW3-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8L2QRU2-1", "uniprot_id": [ { "id": "A0A8L2QRU2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8L2QRU2", "type": "external" } ], "mass": 7554.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "Gng5-ps5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gng5-ps5; Gng5-ps3", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8L2QRU2-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EK08-1", "uniprot_id": [ { "id": "F7EK08_RAT", "url": "https://www.uniprot.org/uniprot/F7EK08", "type": "external" } ], "mass": 55977.0, "length": 493, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp14", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 14", "refseq_ac": [ { "id": "NP_001008302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008302", "type": "external" } ], "gene_names_uniprotkb": "Usp14", "gene_names_refseq": "Usp14", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 14; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ubiquitin specific protease 14", "tax_id": 10116, "disease": "prion disease (Disease Ontology:DOID:649)", "pathway": " (rno:291796); (R-RNO-5689880); (R-RNO-9758274)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "26969276;27545607;28372990", "class_list": "", "function": "Activation of proteasome degradation by IU-1, which is an inhibitor for the deubiquitinating activity of USP14, decreased only the quantity of TH molecules phosphorylated at their Ser19., [RefSeq, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediates the development of cardiac hypertrophy by promoting GSK-3beta phosphorylation., [RefSeq, PubMed]; Pharmacologically inhibiting (with low or high IU1 concentrations) or genetically down-regulating USP14 fail to enhance proteasomal degradation of Ub-proteins or Tau in neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0070628 proteasome binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0007268 chemical synaptic transmission;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050920 regulation of chemotaxis;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F7EK08-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7ETC0-1", "uniprot_id": [ { "id": "F7ETC0_RAT", "url": "https://www.uniprot.org/uniprot/F7ETC0", "type": "external" } ], "mass": 69633.0, "length": 626, "protein_name": "Sphingomyelin phosphodiesterase", "gene_name": "Smpd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smpd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase; 3.1.4.12", "protein_names_refseq": "", "tax_id": 10116, "disease": "Niemann-Pick disease type A (Disease Ontology:DOID:0070111); Niemann-Pick disease type B (Disease Ontology:DOID:0070112); Niemann-Pick disease (Disease Ontology:DOID:14504); Wilson disease (Disease Ontology:DOID:893)", "pathway": " (R-RNO-9769739); (R-RNO-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form., [UniProtKB, UniProtKB]; In the lysosomes, converts sphingomyelin to ceramide. Plays an important role in the export of cholesterol from the intraendolysosomal membranes. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Modulates stress-induced apoptosis through the production of ceramide., [UniProtKB, UniProtKB]; This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection. It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair. Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection., [UniProtKB, UniProtKB]; When secreted, modulates cell signaling with its ability to reorganize the plasma membrane by converting sphingomyelin to ceramide. Secreted form is increased in response to stress and inflammatory mediators such as IL1B, IFNG or TNF as well as upon infection with bacteria and viruses. Produces the release of ceramide in the outer leaflet of the plasma membrane playing a central role in host defense. Ceramide reorganizes these rafts into larger signaling platforms that are required to internalize P.aeruginosa, induce apoptosis and regulate the cytokine response in infected cells. In wounded cells, the lysosomal form is released extracellularly in the presence of Ca(2+) and promotes endocytosis and plasma membrane repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061750 acid sphingomyelin phosphodiesterase activity;GO:0034480 phosphatidylcholine phospholipase C activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0008203 cholesterol metabolic process;GO:0034612 response to tumor necrosis factor;GO:0043065 positive regulation of apoptotic process;GO:0046513 ceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7ETC0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7EWF8-1", "uniprot_id": [ { "id": "F7EWF8_RAT", "url": "https://www.uniprot.org/uniprot/F7EWF8", "type": "external" } ], "mass": 102333.0, "length": 897, "protein_name": "Anaphase-promoting complex subunit 2", "gene_name": "Anapc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Anapc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "aplastic anemia (Disease Ontology:DOID:12449); primary angle-closure glaucoma (Disease Ontology:DOID:1405); lung adenocarcinoma (Disease Ontology:DOID:3910); lung adenoma (Disease Ontology:DOID:5386); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-983168)", "pathway_count": 15, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0031915 positive regulation of synaptic plasticity;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7EWF8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F237-1", "uniprot_id": [ { "id": "F7F237_RAT", "url": "https://www.uniprot.org/uniprot/F7F237", "type": "external" } ], "mass": 18188.0, "length": 163, "protein_name": "Myb/SANT DNA binding domain containing 5", "gene_name": "Msantd5", "organism": "Rat", "refseq_name": "Myb/SANT DNA binding domain containing 5", "refseq_ac": [ { "id": "NP_001017472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017472", "type": "external" } ], "gene_names_uniprotkb": "Msantd5", "gene_names_refseq": "Msantd5", "protein_names_uniprotkb": "Myb/SANT DNA binding domain containing 5", "protein_names_refseq": "Myb/SANT DNA binding domain containing 5", "tax_id": 10116, "disease": "", "pathway": " (rno:497899)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F237-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F3Q2-1", "uniprot_id": [ { "id": "TEKT5_RAT", "url": "https://www.uniprot.org/uniprot/F7F3Q2", "type": "external" } ], "mass": 62842.0, "length": 558, "protein_name": "Tektin-5", "gene_name": "Tekt5", "organism": "Rat", "refseq_name": "tektin-5", "refseq_ac": [ { "id": "NP_001014246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014246", "type": "external" } ], "gene_names_uniprotkb": "Tekt5", "gene_names_refseq": "RGD1307081; Tek5; Tekt5; Tektin5", "protein_names_uniprotkb": "Tektin-5", "protein_names_refseq": "tektin-5", "tax_id": 10116, "disease": "", "pathway": " (rno:363538)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17924527", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility., [UniProtKB, UniProtKB, UniProtKB]; Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme (PubMed:17924527). Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A-tubule of the sperm flagellum (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tektin5 was located in the middle piece of flagella in rat spermatozoa with no immunolabeling in the heads and the principal piece. it might work as a middle piece component requisite for flagellar stability and sperm motility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7F3Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F497-1", "uniprot_id": [ { "id": "F7F497_RAT", "url": "https://www.uniprot.org/uniprot/F7F497", "type": "external" } ], "mass": 58989.0, "length": 561, "protein_name": "Embryonal Fyn-associated substrate", "gene_name": "Efs", "organism": "Rat", "refseq_name": "embryonal Fyn-associated substrate", "refseq_ac": [ { "id": "NP_001099503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099503", "type": "external" } ], "gene_names_uniprotkb": "Efs", "gene_names_refseq": "Efs", "protein_names_uniprotkb": "Embryonal Fyn-associated substrate", "protein_names_refseq": "embryonal Fyn-associated substrate", "tax_id": 10116, "disease": "Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:290212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion", "go_biological_process": "GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F497-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FF61-1", "uniprot_id": [ { "id": "F7FF61_RAT", "url": "https://www.uniprot.org/uniprot/F7FF61", "type": "external" } ], "mass": 37625.0, "length": 332, "protein_name": "Protein RED C-terminal domain-containing protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein RED C-terminal domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FF61-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FL28-1", "uniprot_id": [ { "id": "F7FL28_RAT", "url": "https://www.uniprot.org/uniprot/F7FL28", "type": "external" } ], "mass": 47979.0, "length": 442, "protein_name": "Napsin-A", "gene_name": "Napsa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Napsa", "gene_names_refseq": "", "protein_names_uniprotkb": "Napsin-A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5683826)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in processing of pneumocyte surfactant precursors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0097208 alveolar lamellar body", "go_biological_process": "GO:0006508 proteolysis;GO:0043129 surfactant homeostasis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FL28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FQ81-1", "uniprot_id": [ { "id": "F7FQ81_RAT", "url": "https://www.uniprot.org/uniprot/F7FQ81", "type": "external" } ], "mass": 44779.0, "length": 401, "protein_name": "Uncharacterized protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FQ81-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RCG9-1", "uniprot_id": [ { "id": "M0RCG9_RAT", "url": "https://www.uniprot.org/uniprot/M0RCG9", "type": "external" } ], "mass": 15323.0, "length": 133, "protein_name": "RNA polymerase II subunit I", "gene_name": "Polr2i", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Polr2i", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA polymerase II subunit I", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:292778); (R-RNO-112382); (R-RNO-113418); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 23, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005665 RNA polymerase II, core complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RCG9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K254-1", "uniprot_id": [ { "id": "A0A0G2K254_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K254", "type": "external" } ], "mass": 73605.0, "length": 641, "protein_name": "Kinetochore protein NDC80", "gene_name": "Ndc80", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndc80", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinetochore protein NDC80", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0030332 cyclin binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K254-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K269-1", "uniprot_id": [ { "id": "A0A0G2K269_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K269", "type": "external" } ], "mass": 49816.0, "length": 452, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1", "gene_name": "Dph1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dph1", "gene_names_refseq": "", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; 2.5.1.108; Diphthamide biosynthesis protein 1; Diphtheria toxin resistance protein 1; Ovarian cancer-associated gene 1 protein homolog; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); diphthamide deficiency syndrome (Disease Ontology:DOID:0070476); diphthamide deficiency syndrome 1 (Disease Ontology:DOID:0070477)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.108", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K269-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K6D8-1", "uniprot_id": [ { "id": "A0A0G2K6D8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K6D8", "type": "external" } ], "mass": 36028.0, "length": 319, "protein_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "gene_name": "Sirt4", "organism": "Rat", "refseq_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "refseq_ac": [ { "id": "NP_001100617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100617", "type": "external" } ], "gene_names_uniprotkb": "Sirt4; SIRT4", "gene_names_refseq": "Sirt4", "protein_names_uniprotkb": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; 2.3.1.-; 2.3.1.286; 2.4.2.-; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4", "protein_names_refseq": "NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:304539)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "30661205;32865007;33636397", "class_list": "", "function": "Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion., [UniProtKB, HAMAP]; Physiological profile regulation during weight gain and loss by ovariectomized females: importance of SIRT1 and SIRT4., [RefSeq, PubMed]; SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions., [RefSeq, PubMed]; The association between recovery of olfactory function and the increase in bulbar SIRT1 and SIRT4 expression, is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070403 NAD+ binding;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0061690 lipoamidase activity;GO:0034979 NAD-dependent protein lysine deacetylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0046889 positive regulation of lipid biosynthetic process;GO:0071456 cellular response to hypoxia;GO:0006974 DNA damage response;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2K6D8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K878-1", "uniprot_id": [ { "id": "A0A0G2K878_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K878", "type": "external" } ], "mass": 83153.0, "length": 735, "protein_name": "Leucine rich repeat containing 45", "gene_name": "Lrrc45", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrrc45", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine rich repeat containing 45", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0120329 protein localization to centriolar satellite", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K878-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y0B7-1", "uniprot_id": [ { "id": "A0A8I5Y0B7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y0B7", "type": "external" } ], "mass": 46164.0, "length": 395, "protein_name": "HMG box domain-containing protein", "gene_name": "Ubtfl2", "organism": "Rat", "refseq_name": "upstream-binding factor 1-like protein 1", "refseq_ac": [ { "id": "XP_038938789", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038938789", "type": "external" } ], "gene_names_uniprotkb": "Ubtfl2; LOC120094361; Ubtfl1", "gene_names_refseq": "Ubtfl2", "protein_names_uniprotkb": "HMG box domain-containing protein", "protein_names_refseq": "upstream-binding factor 1-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:120094361)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0045943 positive regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y0B7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y1Z3-1", "uniprot_id": [ { "id": "A0A8I5Y1Z3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1Z3", "type": "external" } ], "mass": 151965.0, "length": 1377, "protein_name": "Attractin-like protein 1", "gene_name": "Atrnl1", "organism": "Rat", "refseq_name": "attractin like 1 isoform 1", "refseq_ac": [ { "id": "NP_001418043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418043", "type": "external" } ], "gene_names_uniprotkb": "Atrnl1", "gene_names_refseq": "Atrnl1; RGD1563485", "protein_names_uniprotkb": "Attractin-like protein 1", "protein_names_refseq": "attractin like 1 isoform 1; attractin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-163125)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "May play a role in melanocortin signaling pathways that regulate energy homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8I5Y1Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AI05-1", "uniprot_id": [ { "id": "A0A8I6AI05_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AI05", "type": "external" } ], "mass": 107610.0, "length": 968, "protein_name": "Trafficking kinesin protein 1", "gene_name": "Trak1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trak1", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking kinesin protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); neurodegenerative disease (Disease Ontology:DOID:1289); Stiff-Person syndrome (Disease Ontology:DOID:13366)", "pathway": " (rno:316085); (R-RNO-9013419)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12435728;22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0017022 myosin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0006605 protein targeting;GO:0048813 dendrite morphogenesis;GO:0050772 positive regulation of axonogenesis;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I6AI05-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y5S4-1", "uniprot_id": [ { "id": "A0A8I5Y5S4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y5S4", "type": "external" } ], "mass": 26850.0, "length": 248, "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "Ppih", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppih", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase; 5.2.1.8; PPIase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone., [UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071001 U4/U6 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006457 protein folding;GO:0045070 positive regulation of viral genome replication;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y5S4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y6Q8-1", "uniprot_id": [ { "id": "A0A8I5Y6Q8_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y6Q8", "type": "external" } ], "mass": 129967.0, "length": 1179, "protein_name": "Ankyrin repeat and FYVE domain-containing protein 1", "gene_name": "Ankfy1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ankfy1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and FYVE domain-containing protein 1; Ankyrin repeats hooked to a zinc finger motif; Rab5-binding and ankyrin repeats-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Charlevoix-Saguenay spastic ataxia (Disease Ontology:DOID:0050946)", "pathway": " (rno:303292)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI[3]P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of clathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. Required for podocyte migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0044354 macropinosome;GO:0030904 retromer complex", "go_biological_process": "GO:0034058 endosomal vesicle fusion;GO:0042147 retrograde transport, endosome to Golgi;GO:0048549 positive regulation of pinocytosis;GO:0090160 Golgi to lysosome transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y6Q8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y871-1", "uniprot_id": [ { "id": "A0A8I5Y871_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y871", "type": "external" } ], "mass": 98763.0, "length": 868, "protein_name": "Protein argonaute-1", "gene_name": "Ago1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ago1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein argonaute-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (R-RNO-203927); (R-RNO-426486); (R-RNO-426496); (R-RNO-5578749)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0035198 miRNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0016525 negative regulation of angiogenesis;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y871-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y928-1", "uniprot_id": [ { "id": "A0A8I5Y928_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y928", "type": "external" } ], "mass": 17225.0, "length": 156, "protein_name": "lysozyme", "gene_name": "Lyc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lyc2", "gene_names_refseq": "", "protein_names_uniprotkb": "lysozyme; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y928-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y949-1", "uniprot_id": [ { "id": "A0A8I5Y949_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y949", "type": "external" } ], "mass": 120221.0, "length": 1047, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform", "gene_name": "Pik3cd", "organism": "Rat", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b", "refseq_ac": [ { "id": "NP_001424206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424206", "type": "external" } ], "gene_names_uniprotkb": "Pik3cd", "gene_names_refseq": "Pik3cd", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; 2.7.1.137; 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta", "protein_names_refseq": "catalytic phosphatidylinositol 3-kinase delta; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b; phosphoinositide-3-kinase, catalytic, delta polypeptide", "tax_id": 10116, "disease": "immunodeficiency 14 (Disease Ontology:DOID:0111936); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:366508); (R-RNO-1257604); (R-RNO-1660499); (R-RNO-389357); (R-RNO-512988); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-9027276); (R-RNO-912526); (R-RNO-912631); (R-RNO-983695); (R-RNO-9927354)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "35130772;37277581", "class_list": "", "function": "Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas., [RefSeq, PubMed]; Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8I5Y949-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5YC17-1", "uniprot_id": [ { "id": "A0A8I5YC17_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5YC17", "type": "external" } ], "mass": 41849.0, "length": 357, "protein_name": "LINE-1 retrotransposable element ORF1 protein", "gene_name": "ENSRNOG00000067098", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000067098", "gene_names_refseq": "", "protein_names_uniprotkb": "LINE-1 retrotransposable element ORF1 protein; LINE retrotransposable element 1; LINE1 retrotransposable element 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032197 retrotransposition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5YC17-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZLC5-1", "uniprot_id": [ { "id": "A0A8I5ZLC5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLC5", "type": "external" } ], "mass": 20423.0, "length": 168, "protein_name": "High mobility group protein B4", "gene_name": "Hmgb4l5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hmgb4l5; LOC103694587; LOC691030", "gene_names_refseq": "", "protein_names_uniprotkb": "High mobility group protein B4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:691030)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZLC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZLE0-1", "uniprot_id": [ { "id": "A0A8I5ZLE0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLE0", "type": "external" } ], "mass": 17480.0, "length": 155, "protein_name": "Riboflavin kinase", "gene_name": "Rfk-ps3", "organism": "Rat", "refseq_name": "riboflavin kinase-like", "refseq_ac": [ { "id": "XP_063141355", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063141355", "type": "external" } ], "gene_names_uniprotkb": "Rfk-ps3; AABR07053065.1", "gene_names_refseq": "Rfk-ps3", "protein_names_uniprotkb": "Riboflavin kinase; 2.7.1.26; ATP:riboflavin 5'-phosphotransferase; Flavokinase", "protein_names_refseq": "riboflavin kinase-like", "tax_id": 10116, "disease": "", "pathway": " (rno:311241)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.26", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008531 riboflavin kinase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009231 riboflavin biosynthetic process;GO:0009398 FMN biosynthetic process;GO:0006771 riboflavin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZLE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZLJ1-1", "uniprot_id": [ { "id": "A0A8I5ZLJ1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZLJ1", "type": "external" } ], "mass": 13985.0, "length": 126, "protein_name": "Ig-like domain-containing protein", "gene_name": "Igkvl4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igkvl4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZLJ1-1", "record_type": "protein", "filter_code": "0000000.1000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZMG2-1", "uniprot_id": [ { "id": "A0A8I5ZMG2_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMG2", "type": "external" } ], "mass": 106628.0, "length": 962, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 1", "gene_name": "Fgd1", "organism": "Rat", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001401661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401661", "type": "external" } ], "gene_names_uniprotkb": "Fgd1", "gene_names_refseq": "Fgd1", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 1; Rho/Rac guanine nucleotide exchange factor FGD1; Zinc finger FYVE domain-containing protein 3", "protein_names_refseq": "FYVE, RhoGEF and PH domain-containing protein 1 isoform 1; FYVE, RhoGEF and PH domain-containing protein 1-like; FYVE, RhoGEF and PH domain-containing protein 1", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); prostate cancer (Disease Ontology:DOID:10283); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); invasive ductal carcinoma (Disease Ontology:DOID:3008); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (rno:363460); (R-RNO-193648); (R-RNO-416482); (R-RNO-9013148)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZMG2-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZMP5-1", "uniprot_id": [ { "id": "A0A8I5ZMP5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMP5", "type": "external" } ], "mass": 29633.0, "length": 282, "protein_name": "Carbonyl reductase 2 like 1", "gene_name": "Cbr2l1", "organism": "Rat", "refseq_name": "carbonyl reductase [NADPH] 2-like isoform X1", "refseq_ac": [ { "id": "XP_038943481", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038943481", "type": "external" } ], "gene_names_uniprotkb": "Cbr2l1; LOC688321", "gene_names_refseq": "Cbr2l1", "protein_names_uniprotkb": "Carbonyl reductase 2 like 1", "protein_names_refseq": "carbonyl reductase [NADPH] 2-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:688321)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050038 L-xylulose reductase (NADPH) activity;GO:0004090 carbonyl reductase (NADPH) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "", "go_biological_process": "GO:0005997 xylulose metabolic process;GO:0006006 glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZMP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZMW9-1", "uniprot_id": [ { "id": "A0A8I5ZMW9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMW9", "type": "external" } ], "mass": 194850.0, "length": 1705, "protein_name": "Protein polybromo-1", "gene_name": "Pbrm1", "organism": "Rat", "refseq_name": "protein polybromo-1", "refseq_ac": [ { "id": "NP_001414614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414614", "type": "external" } ], "gene_names_uniprotkb": "Pbrm1", "gene_names_refseq": "Pbrm1; RGD1565549", "protein_names_uniprotkb": "Protein polybromo-1; BRG1-associated factor 180", "protein_names_refseq": "protein polybromo-1", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); lung small cell carcinoma (Disease Ontology:DOID:5409); Crohn's disease (Disease Ontology:DOID:8778); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-3214858); (R-RNO-8939243); (R-RNO-9933939)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0016586 RSC-type complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0000776 kinetochore", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZMW9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZNM1-1", "uniprot_id": [ { "id": "A0A8I5ZNM1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZNM1", "type": "external" } ], "mass": 12670.0, "length": 110, "protein_name": "Ig-like domain-containing protein", "gene_name": "AABR07017838.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07017838.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0042101 T cell receptor complex", "go_biological_process": "GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZNM1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZP19-1", "uniprot_id": [ { "id": "A0A8I5ZP19_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP19", "type": "external" } ], "mass": 29961.0, "length": 264, "protein_name": "CD99 antigen-like protein 2", "gene_name": "ENSRNOG00000068667", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000068667", "gene_names_refseq": "", "protein_names_uniprotkb": "CD99 antigen-like protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZP19-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZP21-1", "uniprot_id": [ { "id": "A0A8I5ZP21_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP21", "type": "external" } ], "mass": 34560.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or10p22", "organism": "Rat", "refseq_name": "olfactory receptor Olr875", "refseq_ac": [ { "id": "NP_001000054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000054", "type": "external" } ], "gene_names_uniprotkb": "Or10p22; LOC120093833; Olr875; Or10p1l1", "gene_names_refseq": "Olr875; Olr876; Or10p22", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 875; olfactory receptor 876; olfactory receptor Olr875; olfactory receptor Olr876; olfactory receptor gene Olr875; olfactory receptor gene Olr876", "tax_id": 10116, "disease": "", "pathway": " (rno:288789)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZP21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZQD4-1", "uniprot_id": [ { "id": "A0A8I5ZQD4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQD4", "type": "external" } ], "mass": 867852.0, "length": 7701, "protein_name": "Dystonin", "gene_name": "Dst", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dst", "gene_names_refseq": "", "protein_names_uniprotkb": "Dystonin; Bullous pemphigoid antigen 1; Dystonia musculorum protein; Hemidesmosomal plaque protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); hereditary sensory and autonomic neuropathy type 6 (Disease Ontology:DOID:0070151); cancer (Disease Ontology:DOID:162); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (R-RNO-446107); (R-RNO-9013420); (R-RNO-9013424); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "16641100;22673903;38843836", "class_list": "", "function": "Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for bundling actin filaments around the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0008090 retrograde axonal transport;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8I5ZQD4-1", "record_type": "protein", "filter_code": "0000000.1000111.000010.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZQF3-1", "uniprot_id": [ { "id": "A0A8I5ZQF3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQF3", "type": "external" } ], "mass": 35047.0, "length": 313, "protein_name": "Olfactory receptor", "gene_name": "ENSRNOG00000064353", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000064353", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZQF3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZR28-1", "uniprot_id": [ { "id": "A0A8I5ZR28_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR28", "type": "external" } ], "mass": 49176.0, "length": 440, "protein_name": "Protein eva-1 homolog C", "gene_name": "Eva1c", "organism": "Rat", "refseq_name": "eva-1 homolog C isoform 1", "refseq_ac": [ { "id": "NP_001417718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001417718", "type": "external" } ], "gene_names_uniprotkb": "Eva1c; Fam176c", "gene_names_refseq": "Eva1c; Fam176c; RGD1307569", "protein_names_uniprotkb": "Protein eva-1 homolog C; Protein FAM176C", "protein_names_refseq": "eva-1 homolog C isoform 1; family with sequence similarity 176, member C", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds heparin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZR28-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZR32-1", "uniprot_id": [ { "id": "A0A8I5ZR32_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZR32", "type": "external" } ], "mass": 53531.0, "length": 495, "protein_name": "Polypyrimidine tract binding protein 1, pseudogene 3", "gene_name": "Ptbp1-ps3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptbp1-ps3", "gene_names_refseq": "", "protein_names_uniprotkb": "Polypyrimidine tract binding protein 1, pseudogene 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0045595 regulation of cell differentiation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZR32-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSN3-1", "uniprot_id": [ { "id": "A0A8I5ZSN3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSN3", "type": "external" } ], "mass": 10922.0, "length": 99, "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000068163", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000068163", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZSN3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZT32-1", "uniprot_id": [ { "id": "A0A8I5ZT32_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZT32", "type": "external" } ], "mass": 24061.0, "length": 218, "protein_name": "Guanylate kinase", "gene_name": "Guk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Guk1", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate kinase; 2.7.4.8; GMP kinase; Guanylate kinase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome-21 (Disease Ontology:DOID:0051029); cancer (Disease Ontology:DOID:162)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.8", "type": "external" } ], "go_molecular_function": "GO:0004385 GMP kinase activity;GO:0050145 nucleoside monophosphate kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0019673 GDP-mannose metabolic process;GO:0006185 dGDP biosynthetic process;GO:0046054 dGMP metabolic process;GO:0046060 dATP metabolic process;GO:0046711 GDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZT32-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A7V5-1", "uniprot_id": [ { "id": "A0A8I6A7V5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A7V5", "type": "external" } ], "mass": 53345.0, "length": 477, "protein_name": "Cyclin-dependent kinase 14", "gene_name": "Cdk14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk14", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-dependent kinase 14; 2.7.11.22; Cell division protein kinase 14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362316)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": 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Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070889 platelet alpha granule organization;GO:0007596 blood coagulation;GO:0035855 megakaryocyte development;GO:0030220 platelet formation;GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8I6A0G8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A0J6-1", "uniprot_id": [ { "id": "A0A8I6A0J6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A0J6", "type": "external" } ], "mass": 16945.0, "length": 148, "protein_name": "Acyl carrier protein", "gene_name": "ENSRNOG00000070521", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000070521", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl carrier protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carrier of the growing fatty acid chain in fatty acid biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000035 acyl binding;GO:0000036 acyl carrier activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A0J6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A1Q4-1", "uniprot_id": [ { "id": "A0A8I6A1Q4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A1Q4", "type": "external" } ], "mass": 34137.0, "length": 309, "protein_name": "Olfactory receptor", "gene_name": "Or1o11c", "organism": "Rat", "refseq_name": "olfactory receptor Olr1724", "refseq_ac": [ { "id": "NP_001000277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000277", "type": "external" } ], "gene_names_uniprotkb": "Or1o11c; 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6A1Q4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A2R5-1", "uniprot_id": [ { "id": "A0A8I6A2R5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A2R5", "type": "external" } ], "mass": 37073.0, "length": 332, "protein_name": "Ankyrin repeat domain-containing protein 2", "gene_name": "Ankrd2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ankrd2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 2; Skeletal muscle ankyrin repeat protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Functions as a negative regulator of myocyte differentiation. 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Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030891 VCB complex;GO:0070449 elongin complex", "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AJR9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZZR5-1", "uniprot_id": [ { "id": "A0A8I5ZZR5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZR5", "type": "external" } ], "mass": 305858.0, "length": 2688, "protein_name": "Neurobeachin-like 1", "gene_name": "Nbeal1", "organism": "Rat", "refseq_name": "neurobeachin-like protein 1 isoform X2", "refseq_ac": [ { "id": "XP_038940780", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038940780", "type": "external" } ], "gene_names_uniprotkb": "Nbeal1; RGD1311357", "gene_names_refseq": "Nbeal1", "protein_names_uniprotkb": "Neurobeachin-like 1", "protein_names_refseq": "neurobeachin-like protein 1 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:689253)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5ZZR5-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A571-1", "uniprot_id": [ { "id": "A0A8I6A571_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A571", "type": "external" } ], "mass": 159609.0, "length": 1395, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 47", "gene_name": "Usp47", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 47 isoform X1", "refseq_ac": [ { "id": "XP_006230106", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230106", "type": "external" } ], "gene_names_uniprotkb": "Usp47", "gene_names_refseq": "Usp47", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 47; 3.4.19.12; Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 47 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:308896); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity;GO:0071987 WD40-repeat domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006284 base-excision repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6A571-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AGP4-1", "uniprot_id": [ { "id": "A0A8I6AGP4_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AGP4", "type": "external" } ], "mass": 45876.0, "length": 417, "protein_name": "SLX4 interacting protein", "gene_name": "Slx4ip", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slx4ip; AC132740.1", "gene_names_refseq": "", "protein_names_uniprotkb": "SLX4 interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:499895)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032197 retrotransposition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AGP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZMW1-1", "uniprot_id": [ { "id": "A0A8I5ZMW1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZMW1", "type": "external" } ], "mass": 338894.0, "length": 3035, "protein_name": "Dmx-like 2", "gene_name": "Dmxl2", "organism": "Rat", "refseq_name": "dmX-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001414314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414314", "type": "external" } ], "gene_names_uniprotkb": "Dmxl2", "gene_names_refseq": "Dmxl2-ps1; Dmxl2", "protein_names_uniprotkb": "Dmx-like 2", "protein_names_refseq": "Dmx-like 2, pseudogene 1; dmX-like protein 2 isoform 2; dmX-like protein 2", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 71 (Disease Ontology:DOID:0080267); developmental and epileptic encephalopathy 81 (Disease Ontology:DOID:0112217)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "18683930;22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0043291 RAVE complex;GO:0098992 neuronal dense core vesicle;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0007420 brain development;GO:0042593 glucose homeostasis;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I5ZMW1-1", "record_type": "protein", "filter_code": "0000000.0000110.001000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6A540-1", "uniprot_id": [ { "id": "A0A8I6A540_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6A540", "type": "external" } ], "mass": 170526.0, "length": 1516, "protein_name": "peptidylprolyl isomerase", "gene_name": "Nktr", "organism": "Rat", "refseq_name": "NK-tumor recognition protein isoform X1", "refseq_ac": [ { "id": "XP_038938667", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038938667", "type": "external" } ], "gene_names_uniprotkb": "Nktr; 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Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that the IL-1beta-dependent transdifferentiation of VSMCs is associated with the de novo expression of a new family of AC8 isoforms. These isoforms are catalytically inactive with dominant-negative effects, decreasing total cAMP production. 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Mcpt4", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast cell protease 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8L2QF09-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0A0-1", "uniprot_id": [ { "id": "A0A0G2K0A0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0A0", "type": "external" } ], "mass": 47294.0, "length": 411, "protein_name": "Cytohesin 4", "gene_name": "Cyth4", "organism": "Rat", "refseq_name": "cytohesin-4 isoform X2", "refseq_ac": [ { "id": "XP_017450546", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450546", "type": "external" } ], "gene_names_uniprotkb": "Cyth4", "gene_names_refseq": "Cyth4; Pscd4; RGD1564842", "protein_names_uniprotkb": "Cytohesin 4", "protein_names_refseq": "cytohesin-4 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:500906); (R-RNO-6811438)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0030054 cell junction;GO:0005886 plasma membrane;GO:0099243 extrinsic component of synaptic membrane", "go_biological_process": "GO:0032012 regulation of ARF protein signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K0A0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AUV5-1", "uniprot_id": [ { "id": "A0A8I6AUV5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AUV5", "type": "external" } ], "mass": 285218.0, "length": 2535, "protein_name": "Histone-lysine N-methyltransferase SETD2", "gene_name": "Setd2", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase SETD2", "refseq_ac": [ { "id": "NP_001388092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388092", "type": "external" } ], "gene_names_uniprotkb": "Setd2", "gene_names_refseq": "Setd2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETD2; 2.1.1.359; Lysine N-methyltransferase 3A; Protein-lysine N-methyltransferase SETD2; SET domain-containing protein 2", "protein_names_refseq": "histone-lysine N-methyltransferase SETD2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); autosomal dominant intellectual developmental disorder 70 (Disease Ontology:DOID:0061043); stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); malignant mesothelioma (Disease Ontology:DOID:1790); liver cancer (Disease Ontology:DOID:3571); lung adenocarcinoma (Disease Ontology:DOID:3910); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); malignant pleural mesothelioma (Disease Ontology:DOID:7474); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-3214841)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;36260529", "class_list": "", "function": "N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0140955 histone H3K36 trimethyltransferase activity;GO:0046872 metal ion binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0043014 alpha-tubulin binding;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0032259 methylation;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8I6AUV5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6APC0-1", "uniprot_id": [ { "id": "A0A8I6APC0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6APC0", "type": "external" } ], "mass": 64808.0, "length": 590, "protein_name": "Immunoglobulin heavy constant epsilon", "gene_name": "Ighm", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighm; Ighv", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant epsilon", "protein_names_refseq": "", "tax_id": 10116, "disease": "B cell deficiency (Disease Ontology:DOID:2115)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6APC0-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEM8-1", "uniprot_id": [ { "id": "D3ZEM8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEM8", "type": "external" } ], "mass": 92902.0, "length": 812, "protein_name": "Pre-rRNA-processing protein TSR1 homolog", "gene_name": "Tsr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tsr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-rRNA-processing protein TSR1 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040)", "pathway": " (R-RNO-6791226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required during maturation of the 40S ribosomal subunit in the nucleolus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030686 90S preribosome", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEM8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GFU3-1", "uniprot_id": [ { "id": "A0A8I6GFU3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GFU3", "type": "external" } ], "mass": 252017.0, "length": 2252, "protein_name": "Supervillin", "gene_name": "Svil", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Svil", "gene_names_refseq": "", "protein_names_uniprotkb": "Supervillin; Archvillin; p205/p250", "protein_names_refseq": "", "tax_id": 10116, "disease": "myofibrillar myopathy 10 (Disease Ontology:DOID:0112108)", "pathway": " (rno:361256)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0002102 podosome;GO:0032154 cleavage furrow;GO:0030496 midbody;GO:0042995 cell projection", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0061061 muscle structure development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GFU3-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNB9-1", "uniprot_id": [ { "id": "B0BNB9_RAT", "url": "https://www.uniprot.org/uniprot/B0BNB9", "type": "external" } ], "mass": 49094.0, "length": 458, "protein_name": "Serine protease HTRA2, mitochondrial", "gene_name": "Htra2", "organism": "Rat", "refseq_name": "serine protease HTRA2, mitochondrial", "refseq_ac": [ { "id": "NP_001100069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100069", "type": "external" } ], "gene_names_uniprotkb": "Htra2", "gene_names_refseq": "Htra2; Prss25", "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108; High temperature requirement protein A2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI", "protein_names_refseq": "high temperature requirement protein A2; protease, serine, 25; serine protease HTRA2, mitochondrial", "tax_id": 10116, "disease": "3-methylglutaconic aciduria type 8 (Disease Ontology:DOID:0070000); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); asphyxia neonatorum (Disease Ontology:DOID:11088); cryptorchidism (Disease Ontology:DOID:11383); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); middle cerebral artery infarction (Disease Ontology:DOID:3525); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:297376); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "29581019;30286467;32945404;34677809", "class_list": "", "function": "Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharideinduced acute pneumonia in rats., [RefSeq, PubMed]; Local high expression of Apo-J in the peripheral regions may play a neuroprotective role by inhibiting apoptosis via the Omi/HtrA2 pathway after hemorrhage, [RefSeq, PubMed]; Omi inhibition ameliorates neuron apoptosis and neurological deficit after subarachnoid hemorrhage in rats., [RefSeq, PubMed]; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis., [UniProtKB, UniProtKB]; The inhibition of Omi/HtrA2 by UCF-101 leads to neuroprotection by inhibiting the cytosolic translocation of Omi/HtrA2 and antagonizing the caspase-dependent apoptosis pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.108", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:1990948 ubiquitin ligase inhibitor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006508 proteolysis;GO:0008344 adult locomotory behavior;GO:0030900 forebrain development;GO:0035556 intracellular signal transduction;GO:0040014 regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B0BNB9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALM0-1", "uniprot_id": [ { "id": "A0A8I6ALM0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALM0", "type": "external" } ], "mass": 12080.0, "length": 108, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000069828", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000069828", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALM0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA84-1", "uniprot_id": [ { "id": "D3ZA84_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA84", "type": "external" } ], "mass": 273540.0, "length": 2559, "protein_name": "Talin 2", "gene_name": "Tln2", "organism": "Rat", "refseq_name": "talin-2 isoform X1", "refseq_ac": [ { "id": "XP_008764624", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764624", "type": "external" } ], "gene_names_uniprotkb": "Tln2", "gene_names_refseq": "RGD1565416; Tln2", "protein_names_uniprotkb": "Talin 2", "protein_names_refseq": "talin-2 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JUI0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005200 structural constituent of cytoskeleton;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0001726 ruffle", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0007155 cell adhesion;GO:0099140 presynaptic actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZA84-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5ZSJ6-1", "uniprot_id": [ { "id": "A0A8I5ZSJ6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5ZSJ6", "type": "external" } ], "mass": 64017.0, "length": 555, "protein_name": "E3 ubiquitin-protein ligase ARIH1", "gene_name": "Arih1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase ARIH1", "refseq_ac": [ { "id": "NP_001013126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013126", "type": "external" } ], "gene_names_uniprotkb": "Arih1", "gene_names_refseq": "Arih1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase ARIH1; 2.3.2.31; E3 ubiquitin-protein ligase arih1; Protein ariadne-1 homolog; UbcH7-binding protein; Ubiquitin-conjugating enzyme E2-binding protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase ARIH1; ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1; ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:300756); (R-RNO-1169408); (R-RNO-9833482); (R-RNO-9909505)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I5ZSJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G705-1", "uniprot_id": [ { "id": "RBPMS_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G705", "type": "external" } ], "mass": 21816.0, "length": 197, "protein_name": "RNA-binding protein with multiple splicing", "gene_name": "Rbpms", "organism": "Rat", "refseq_name": "RNA-binding protein with multiple splicing isoform 2", "refseq_ac": [ { "id": "NP_001258173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258173", "type": "external" } ], "gene_names_uniprotkb": "Rbpms", "gene_names_refseq": "RBP-MS; RGD1561067; Rbpms", "protein_names_uniprotkb": "RNA-binding protein with multiple splicing; RBP-MS; RBPMS", "protein_names_refseq": "RNA binding protein gene with multiple splicing; RNA binding protein with multiple splicing; RNA-binding protein with multiple splicing isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:498642)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19737887;31283468;37548402", "class_list": "", "function": "Acts as a regulator of pre-mRNA alternative splicing (AS) (PubMed:31283468). Binds mRNA (By similarity). Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform 1 (PubMed:31283468). Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins (By similarity)., [UniProtKB, UniProtKB, PubMed]; Data indicate RNA-Binding Protein with Multiple Splicing (RBPMS) as a critical regulator of numerous alternative splicing (AS) events in vascular smooth muscle cells (SMCs) Publication Status: Online-Only, [RefSeq, PubMed]; RNA binding protein that mediates pre-mRNA alternative splicing (AS) regulation (PubMed:31283468, PubMed:37548402). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets (PubMed:31283468, PubMed:37548402). Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (PubMed:31283468, PubMed:37548402). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (By similarity). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (PubMed:37548402)., [UniProtKB, UniProtKB, PubMed, PubMed]; The data indicate that in the retina RBPMS is selectively expressed in RGCs and therefore could serve as a marker for RGC quantification in normal retinas and for estimation of RGC loss in ocular neuropathies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZR01;F1M9Y9", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0097157 pre-mRNA intronic binding;GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0060395 SMAD protein signal transduction;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8I6G705-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AG33-1", "uniprot_id": [ { "id": "A0A8I6AG33_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AG33", "type": "external" } ], "mass": 101268.0, "length": 890, "protein_name": "Transportin-1", "gene_name": "Tnpo1", "organism": "Rat", "refseq_name": "transportin-1 isoform b", "refseq_ac": [ { "id": "NP_001094162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094162", "type": "external" } ], "gene_names_uniprotkb": "Tnpo1", "gene_names_refseq": "Tnpo1", "protein_names_uniprotkb": "Transportin-1; Importin beta-2; Karyopherin beta-2", "protein_names_refseq": "transportin-1 isoform b", "tax_id": 10116, "disease": "intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (Disease Ontology:DOID:0081262)", "pathway": " (rno:309126); (R-RNO-450513); (R-RNO-5620924)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AG33-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCH6-1", "uniprot_id": [ { "id": "D3ZCH6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCH6", "type": "external" } ], "mass": 29517.0, "length": 256, "protein_name": "Ribonuclease T2", "gene_name": "Rnaset2", "organism": "Rat", "refseq_name": "ribonuclease T2 precursor", "refseq_ac": [ { "id": "NP_001099680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099680", "type": "external" } ], "gene_names_uniprotkb": "Rnaset2", "gene_names_refseq": "Rnaset2", "protein_names_uniprotkb": "Ribonuclease T2", "protein_names_refseq": "ribonuclease T2 precursor", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); RNASET2-deficient cystic leukoencephalopathy (Disease Ontology:DOID:0081007); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); colon adenocarcinoma (Disease Ontology:DOID:234); gastric adenocarcinoma (Disease Ontology:DOID:3717); Lynch syndrome (Disease Ontology:DOID:3883); pulmonary neuroendocrine tumor (Disease Ontology:DOID:5410)", "pathway": " (rno:292306)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29752287", "class_list": "", "function": "RNaseT2 knockout rats exhibited memory deficits. Publication Status: Online-Only, [RefSeq, PubMed]; Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0033897 ribonuclease T2 activity;GO:0016787 hydrolase activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0043202 lysosomal lumen;GO:0005615 extracellular space;GO:0005758 mitochondrial intermembrane space;GO:0005788 endoplasmic reticulum lumen;GO:0005764 lysosome", "go_biological_process": "GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZCH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6APQ3-1", "uniprot_id": [ { "id": "A0A8I6APQ3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6APQ3", "type": "external" } ], "mass": 34016.0, "length": 308, "protein_name": "NFKB inhibitor interacting Ras-like 1", "gene_name": "Nkiras1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nkiras1", "gene_names_refseq": "", "protein_names_uniprotkb": "NFKB inhibitor interacting Ras-like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1810476); (R-RNO-445989); (R-RNO-933542)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0043129 surfactant homeostasis;GO:0048286 lung alveolus development;GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6APQ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALB1-1", "uniprot_id": [ { "id": "A0A8I6ALB1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALB1", "type": "external" } ], "mass": 226598.0, "length": 2040, "protein_name": "Cytoskeleton-associated protein 5", "gene_name": "Ckap5", "organism": "Rat", "refseq_name": "cytoskeleton-associated protein 5 isoform X1", "refseq_ac": [ { "id": "XP_017447664", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017447664", "type": "external" } ], "gene_names_uniprotkb": "Ckap5", "gene_names_refseq": "Ckap5", "protein_names_uniprotkb": "Cytoskeleton-associated protein 5", "protein_names_refseq": "cytoskeleton-associated protein 5 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:311191); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9648025)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "18683930;22673903;38843836", "class_list": "", "function": "Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051010 microtubule plus-end binding;GO:0061863 microtubule plus end polymerase;GO:0008017 microtubule binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030425 dendrite", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0007051 spindle organization;GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity;GO:0046959 habituation;GO:0032289 central nervous system myelin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A8I6ALB1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AU51-1", "uniprot_id": [ { "id": "A0A8I6AU51_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AU51", "type": "external" } ], "mass": 41476.0, "length": 386, "protein_name": "Zinc finger C2HC domain-containing protein 1A", "gene_name": "Zc2hc1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zc2hc1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger C2HC domain-containing protein 1A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A8I6AU51-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6GLI1-1", "uniprot_id": [ { "id": "A0A8I6GLI1_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6GLI1", "type": "external" } ], "mass": 154786.0, "length": 1397, "protein_name": "SAM and SH3 domain-containing protein 1", "gene_name": "Sash1", "organism": "Rat", "refseq_name": "SAM and SH3 domain-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_038957407", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038957407", "type": "external" } ], "gene_names_uniprotkb": "Sash1; RGD1566017", "gene_names_refseq": "RGD1566017; Sash1", "protein_names_uniprotkb": "SAM and SH3 domain-containing protein 1", "protein_names_refseq": "SAM and SH3 domain-containing protein 1 isoform X1", "tax_id": 10116, "disease": "dyschromatosis universalis hereditaria (Disease Ontology:DOID:0060304)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:1900745 positive regulation of p38MAPK cascade;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6GLI1-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFL3-1", "uniprot_id": [ { "id": "D3ZFL3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFL3", "type": "external" } ], "mass": 143205.0, "length": 1292, "protein_name": "mitogen-activated protein kinase kinase kinase", "gene_name": "Map3k6", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 6", "refseq_ac": [ { "id": "NP_001101379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101379", "type": "external" } ], "gene_names_uniprotkb": "Map3k6", "gene_names_refseq": "Map3k6", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase kinase; 2.7.11.25", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 6", "tax_id": 10116, "disease": "alcohol use disorder (Disease 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"reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004709 MAP kinase kinase kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007254 JNK cascade;GO:0038066 p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFL3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F8B8-1", "uniprot_id": [ { "id": "F7F8B8_RAT", "url": "https://www.uniprot.org/uniprot/F7F8B8", "type": "external" } ], "mass": 27180.0, "length": 238, "protein_name": "Max-like protein X", "gene_name": "Mlx", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mlx", "gene_names_refseq": "", "protein_names_uniprotkb": "Max-like protein X; Max-like bHLHZip protein; Protein BigMax; Transcription factor-like protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); Takayasu's arteritis (Disease Ontology:DOID:2508)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006913 nucleocytoplasmic transport;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7F8B8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AQ87-1", "uniprot_id": [ { "id": "A0A8I6AQ87_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AQ87", "type": "external" } ], "mass": 11550.0, "length": 98, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "gene_name": "Uqcc5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Uqcc5", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0034551 mitochondrial respiratory chain complex III assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AQ87-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G604-1", "uniprot_id": [ { "id": "A0A8I6G604_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G604", "type": "external" } ], "mass": 44013.0, "length": 388, "protein_name": "Lectin, mannose-binding 2-like", "gene_name": "Lman2l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lman2l", "gene_names_refseq": "", "protein_names_uniprotkb": "Lectin, mannose-binding 2-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 69 (Disease Ontology:DOID:0061042); autosomal recessive intellectual developmental disorder 52 (Disease Ontology:DOID:0081215)", "pathway": " (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0046872 metal ion binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6G604-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6B3E0-1", "uniprot_id": [ { "id": "A0A8I6B3E0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6B3E0", "type": "external" } ], "mass": 213538.0, "length": 1933, "protein_name": "Protocadherin-15", "gene_name": "Pcdh15", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcdh15", "gene_names_refseq": "", "protein_names_uniprotkb": "Protocadherin-15", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 23 (Disease Ontology:DOID:0110481); Usher syndrome type 1D (Disease Ontology:DOID:0110831); Usher syndrome type 1F (Disease Ontology:DOID:0110832)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032420 stereocilium;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048839 inner ear development;GO:0042491 inner ear auditory receptor cell differentiation;GO:0001964 startle response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6B3E0-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDH4-1", "uniprot_id": [ { "id": "D3ZDH4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDH4", "type": "external" } ], "mass": 108554.0, "length": 977, "protein_name": "Ephrin type-A receptor 1", "gene_name": "Epha1", "organism": "Rat", "refseq_name": "ephrin type-A receptor 1 precursor", "refseq_ac": [ { "id": "NP_001101328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101328", "type": "external" } ], "gene_names_uniprotkb": "Epha1", "gene_names_refseq": "Epha1", "protein_names_uniprotkb": "Ephrin type-A receptor 1; 2.7.10.1", "protein_names_refseq": "ephrin receptor EphA1; ephrin type-A receptor 1 precursor; ephrin type-A receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312279); (R-RNO-2682334); (R-RNO-3928663); (R-RNO-3928665)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "18308734;22673903", "class_list": "", "function": "I 12 acquired a higher affinity toward EphA2 with K(d) 18 nm and inhibited vascular endothelial growth factor-dependent angiogenic invasion in a Matrigel plug assay, [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005003 ephrin receptor activity;GO:0019901 protein kinase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030335 positive regulation of cell migration;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZDH4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8J6-1", "uniprot_id": [ { "id": "D3Z8J6_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8J6", "type": "external" } ], "mass": 72030.0, "length": 670, "protein_name": "Endosomal transmembrane epsin interactor 3", "gene_name": "Entrep3", "organism": "Rat", "refseq_name": "protein ENTREP3 isoform 4", "refseq_ac": [ { "id": "NP_001426691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426691", "type": "external" } ], "gene_names_uniprotkb": "Entrep3; Fam189b", "gene_names_refseq": "Entrep3; Fam189b; RGD1306107", "protein_names_uniprotkb": "Endosomal transmembrane epsin interactor 3", "protein_names_refseq": "family with sequence similarity 189, member B; protein ENTREP3 isoform 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "GO:0016020 membrane;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z8J6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6B1T5-1", "uniprot_id": [ { "id": "A0A8I6B1T5_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6B1T5", "type": "external" } ], "mass": 84364.0, "length": 807, "protein_name": "Mediator of RNA polymerase II transcription subunit 25", "gene_name": "Med25", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Med25", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 25", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001223 transcription coactivator binding;GO:0046965 nuclear retinoid X receptor binding;GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0016592 mediator complex;GO:0005634 nucleus;GO:0070847 core mediator complex", "go_biological_process": "GO:2001178 positive regulation of mediator complex assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6B1T5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AKW0-1", "uniprot_id": [ { "id": "A0A8I6AKW0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AKW0", "type": "external" } ], "mass": 315043.0, "length": 2952, "protein_name": "Trinucleotide repeat-containing gene 18 protein", "gene_name": "Tnrc18", "organism": "Rat", "refseq_name": "trinucleotide repeat-containing gene 18 protein isoform X1", "refseq_ac": [ { "id": "XP_038945299", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038945299", "type": "external" } ], "gene_names_uniprotkb": "Tnrc18", "gene_names_refseq": "Tnrc18; Zfp469", "protein_names_uniprotkb": "Trinucleotide repeat-containing gene 18 protein", "protein_names_refseq": "trinucleotide repeat-containing gene 18 protein isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:304302)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0062072 histone H3K9me2/3 reader activity;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0071168 protein localization to chromatin;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A8I6AKW0-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALP3-1", "uniprot_id": [ { "id": "A0A8I6ALP3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALP3", "type": "external" } ], "mass": 31082.0, "length": 287, "protein_name": "CD83 molecule", "gene_name": "Cd83", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd83", "gene_names_refseq": "", "protein_names_uniprotkb": "CD83 molecule", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032743 positive regulation of interleukin-2 production;GO:0032733 positive regulation of interleukin-10 production;GO:0032713 negative regulation of interleukin-4 production;GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALP3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ALZ6-1", "uniprot_id": [ { "id": "A0A8I6ALZ6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ALZ6", "type": "external" } ], "mass": 11925.0, "length": 107, "protein_name": "Ig-like domain-containing protein", "gene_name": "ENSRNOG00000067516", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000067516", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ALZ6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AM56-1", "uniprot_id": [ { "id": "A0A8I6AM56_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AM56", "type": "external" } ], "mass": 143833.0, "length": 1261, "protein_name": "PTPRF interacting protein alpha 2", "gene_name": "Ppfia2", "organism": "Rat", "refseq_name": "liprin-alpha-2 isoform X12", "refseq_ac": [ { "id": "XP_063119856", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063119856", "type": "external" } ], "gene_names_uniprotkb": "Ppfia2", "gene_names_refseq": "Ppfia2", "protein_names_uniprotkb": "PTPRF interacting protein alpha 2", "protein_names_refseq": "liprin-alpha-2 isoform X12", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-388844)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098919 structural constituent of postsynaptic density;GO:0099181 structural constituent of presynapse", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0060998 regulation of dendritic spine development;GO:0061001 regulation of dendritic spine morphogenesis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099519 dense core granule cytoskeletal transport;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6AM56-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AMG7-1", "uniprot_id": [ { "id": "A0A8I6AMG7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AMG7", "type": "external" } ], "mass": 37324.0, "length": 328, "protein_name": "Olfactory receptor", "gene_name": "Or11h4d", "organism": "Rat", "refseq_name": "olfactory receptor Olr1635", "refseq_ac": [ { "id": "NP_001000970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000970", "type": "external" } ], "gene_names_uniprotkb": "Or11h4d; Or11h4", "gene_names_refseq": "Olr1635; Or11h4", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1635; olfactory receptor Olr1635; olfactory receptor gene Olr1635", "tax_id": 10116, "disease": "", "pathway": " (rno:405325)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Beta-chimerin; Rho GTPase-activating protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase-activating protein for p21-rac., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AP97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6APG6-1", "uniprot_id": [ { "id": "A0A8I6APG6_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6APG6", "type": "external" } ], "mass": 112514.0, "length": 975, "protein_name": "Importin-11", "gene_name": "ENSRNOG00000062438; 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Nulp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome quality control complex subunit TCF25; Nuclear localized protein 1; TCF-25; Transcription factor 25", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9954709)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32805187", "class_list": "", "function": "Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (By similarity). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (PubMed:32805187). 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(R-RNO-5663220); (R-RNO-8980692); (R-RNO-9013106)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016477 cell migration;GO:0046847 filopodium assembly;GO:0030036 actin cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0030866 cortical actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ART4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ARY0-1", "uniprot_id": [ { "id": "A0A8I6ARY0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ARY0", "type": "external" } ], "mass": 27653.0, "length": 236, "protein_name": "Acyltransferase PGAP2", "gene_name": "AABR07038703.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07038703.1; 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"glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0007283 spermatogenesis;GO:0030199 collagen fibril organization;GO:0050821 protein stabilization;GO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MK61-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JSK1-1", "uniprot_id": [ { "id": "A0A0G2JSK1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JSK1", "type": "external" } ], "mass": 46477.0, "length": 416, "protein_name": "Serine (or cysteine) proteinase inhibitor, clade A, member 3C", "gene_name": "Serpina3c", "organism": "Rat", "refseq_name": "serine protease inhibitor A3K precursor", "refseq_ac": [ { "id": "NP_036789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036789", "type": "external" } ], "gene_names_uniprotkb": "Serpina3c", "gene_names_refseq": "CPi-21; GHR-P63; Kbp; Klkbp; SPI-2.3; SPI-2; SPI2; Serpina3c; Serpina3k; Spin2b; Spin2", "protein_names_uniprotkb": "Serine (or cysteine) proteinase inhibitor, clade A, member 3C", "protein_names_refseq": "contrapsin-like protease inhibitor 1; growth hormone-regulated proteinase inhibitor; kallikrein-binding protein; kallistatin; serine (or cysteine) peptidase inhibitor, clade A, member 3K; serine protease inhibitor 2b; serine protease inhibitor A3K precursor; serine protease inhibitor A3K; serpin A3K; thyroid hormone-regulated protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); cystic fibrosis (Disease Ontology:DOID:1485); generalized epilepsy (Disease Ontology:DOID:1827); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung adenocarcinoma (Disease Ontology:DOID:3910); collagen disease (Disease Ontology:DOID:854); vasculitis (Disease Ontology:DOID:865)", "pathway": " (rno:24794)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20299474;20351274;21693707;23129128;35147994", "class_list": "", "function": "KBP suppressed lipopolysaccharide-induced TNF-alpha production via upregulating SOCS3 expression., [RefSeq, PubMed]; Pivotal role for alpha1-antichymotrypsin in skin repair, [RefSeq, PubMed]; SERPINA3K is a high-affinity, endogenous antagonist of LRP6, [RefSeq, PubMed]; SERPINA3K is an antifibrogenic factor, and its antifibrogenic activity is through blocking the Wnt pathway. Decreased SERPINA3K levels may contribute to the fibrosis in diabetic retinopathy., [RefSeq, PubMed]; Transient response of serpinA3 during cellular stress., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001937 negative regulation of endothelial cell proliferation;GO:0034097 response to cytokine;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2JSK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JV25-1", "uniprot_id": [ { "id": "A0A0G2JV25_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JV25", "type": "external" } ], "mass": 9918.0, "length": 82, "protein_name": "Uncharacterized protein", "gene_name": "ENSRNOG00000064690", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENSRNOG00000064690", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JV25-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JW78-1", "uniprot_id": [ { "id": "A0A0G2JW78_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JW78", "type": "external" } ], "mass": 50779.0, "length": 462, "protein_name": "Retinoic acid receptor, alpha", "gene_name": "Rara", "organism": "Rat", "refseq_name": "retinoic acid receptor alpha isoform a", "refseq_ac": [ { "id": "NP_001416905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416905", "type": "external" } ], "gene_names_uniprotkb": "Rara", "gene_names_refseq": "Rara", "protein_names_uniprotkb": "Retinoic acid receptor, alpha", "protein_names_refseq": "retinoic acid receptor alpha isoform a", "tax_id": 10116, "disease": "acute promyelocytic leukemia (Disease Ontology:DOID:0060318); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); mood disorder (Disease Ontology:DOID:3324)", "pathway": " (R-RNO-383280); (R-RNO-4090294); (R-RNO-5362517); (R-RNO-9616222)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "28570942;28645189;32205185;33411644;36768908", "class_list": "", "function": "Activation of the RARalpha Attenuated CSF Hypersecretion to Inhibit Hydrocephalus Development via Regulating the MAFB/MSR1 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that retinoic acid receptor alpha (RARalpha) improved the renal function and attenuated the progression of glomerulosclerosis (GS) that was associated with the over-expression of matrix metalloproteinases MMP2 and MMP9., [RefSeq, PubMed]; Data suggest that marginal vitamin A deficiency in pregnant rats down-regulates expression of Rara in hippocampal neurons of offspring leading to decreases in Src and Nr1 expression and causing learning and memory deficits in offspring. (Rara = retinoic acid receptor alpha; Src = proto-oncogene protein src; Nr1 = N-methyl-D-asparate receptor Nr1a), [RefSeq, PubMed]; Retinoic acid receptor alpha activation is necessary and sufficient for plasticity induced by recurrent central apnea., [RefSeq, PubMed]; Vitamin A regulates neural stem cell proliferation in rats after hypoxic-ischemic brain damage via RARa-mediated modulation of the beta-catenin pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0002068 glandular epithelial cell development;GO:0060010 Sertoli cell fate commitment;GO:0060534 trachea cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2JW78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JY57-1", "uniprot_id": [ { "id": "A0A0G2JY57_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JY57", "type": "external" } ], "mass": 35005.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or5m10", "organism": "Rat", "refseq_name": "olfactory receptor Olr466", "refseq_ac": [ { "id": "NP_001000298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000298", "type": "external" } ], "gene_names_uniprotkb": "Or5m10", "gene_names_refseq": "Olr466; Or5m10", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 466; olfactory receptor Olr466; olfactory receptor gene Olr466", "tax_id": 10116, "disease": "", "pathway": " (rno:295736)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JY57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZF6-1", "uniprot_id": [ { "id": "A0A0G2JZF6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZF6", "type": "external" } ], "mass": 19554.0, "length": 166, "protein_name": "NADH:ubiquinone oxidoreductase complex assembly factor 2", "gene_name": "Ndufaf2", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2", "refseq_ac": [ { "id": "NP_001385981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385981", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf2", "gene_names_refseq": "Ndufa12l; Ndufaf2; RGD1560158", "protein_names_uniprotkb": "NADH:ubiquinone oxidoreductase complex assembly factor 2", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; mimitin, mitochondrial", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 10 (Disease Ontology:DOID:0112075)", "pathway": " (rno:361894); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22587331", "class_list": "", "function": "Mimitin overexpression protected INS1E pancreatic beta cells against cytokine-induced caspase 3 activation, mitochondrial membrane potential reduction and ATP production inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JZF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZJ2-1", "uniprot_id": [ { "id": "A0A0G2JZJ2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZJ2", "type": "external" } ], "mass": 34886.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or4b1d", "organism": "Rat", "refseq_name": "olfactory receptor Olr737", "refseq_ac": [ { "id": "NP_001000616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000616", "type": "external" } ], "gene_names_uniprotkb": "Or4b1d", "gene_names_refseq": "Olr737; Or4b1d; tpcr09", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "odorant receptor; olfactory receptor 737; olfactory receptor Olr737; olfactory receptor gene Olr737", "tax_id": 10116, "disease": "", "pathway": " (rno:404808)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JZJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0M2-1", "uniprot_id": [ { "id": "A0A0G2K0M2_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0M2", "type": "external" } ], "mass": 23773.0, "length": 211, "protein_name": "Claudin 34B4", "gene_name": "Cldn34b4", "organism": "Rat", "refseq_name": "claudin-34-like", "refseq_ac": [ { "id": "XP_002730287", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002730287", "type": "external" } ], "gene_names_uniprotkb": "Cldn34b4; LOC100362173", "gene_names_refseq": "Cldn34b4", "protein_names_uniprotkb": "Claudin 34B4", "protein_names_refseq": "claudin-34-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100362173)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K0M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0U8-1", "uniprot_id": [ { "id": "A0A0G2K0U8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0U8", "type": "external" } ], "mass": 60032.0, "length": 528, "protein_name": "tRNA pseudouridine synthase Pus10", "gene_name": "Pus10", "organism": "Rat", "refseq_name": "tRNA pseudouridine synthase Pus10 isoform 1", "refseq_ac": [ { "id": "NP_001388093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388093", "type": "external" } ], "gene_names_uniprotkb": "Pus10", "gene_names_refseq": "Pus10; RGD1306402", "protein_names_uniprotkb": "tRNA pseudouridine synthase Pus10; 5.4.99.25; Coiled-coil domain-containing protein 139; tRNA pseudouridine 55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase", "protein_names_refseq": "pseudouridylate synthase 10; putative tRNA pseudouridine synthase Pus10-like; putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine synthase Pus10 isoform 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0009982 pseudouridine synthase activity;GO:0070878 primary miRNA binding;GO:0106029 tRNA pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0031053 primary miRNA processing;GO:0008033 tRNA processing;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K0U8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0V7-1", "uniprot_id": [ { "id": "A0A0G2K0V7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0V7", "type": "external" } ], "mass": 51359.0, "length": 463, "protein_name": "Radial spoke head 14 homolog", "gene_name": "Rsph14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rsph14; Rtdr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Radial spoke head 14 homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:365552)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001534 radial spoke", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K0V7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K1A7-1", "uniprot_id": [ { "id": "A0A0G2K1A7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K1A7", "type": "external" } ], "mass": 35316.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or4a73", "organism": "Rat", "refseq_name": "olfactory receptor Olr709", "refseq_ac": [ { "id": "NP_001001066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001066", "type": "external" } ], "gene_names_uniprotkb": "Or4a73", "gene_names_refseq": "Olr709; Or4a73", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 709; olfactory receptor Olr709; olfactory receptor gene Olr709", "tax_id": 10116, "disease": "", "pathway": " (rno:405954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K1A7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K1G6-1", "uniprot_id": [ { "id": "A0A0G2K1G6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K1G6", "type": "external" } ], "mass": 20308.0, "length": 176, "protein_name": "Ferritin", "gene_name": "Fthl17b", "organism": "Rat", "refseq_name": "ferritin, heavy polypeptide-like 17, member B", "refseq_ac": [ { "id": "NP_001103837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103837", "type": "external" } ], "gene_names_uniprotkb": "Fthl17b; Fthl17cl1; LOC120099271; LOC691895", "gene_names_refseq": "Fthl17b", "protein_names_uniprotkb": "Ferritin", "protein_names_refseq": "ferritin, heavy polypeptide-like 17, member B", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:691895)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K1G6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K1V3-1", "uniprot_id": [ { "id": "A0A0G2K1V3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K1V3", "type": "external" } ], "mass": 18543.0, "length": 168, "protein_name": "tRNA-splicing endonuclease subunit SEN15", "gene_name": "Tsen15", "organism": "Rat", "refseq_name": "tRNA-splicing endonuclease subunit Sen15 isoform 1", "refseq_ac": [ { "id": "NP_001388243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388243", "type": "external" } ], "gene_names_uniprotkb": "Tsen15", "gene_names_refseq": "RGD1308584; Tsen15", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit SEN15; tRNA-intron endonuclease SEN15; tRNA-splicing endonuclease subunit Sen15", "protein_names_refseq": "TSEN15 tRNA splicing endonuclease subunit; tRNA splicing endonuclease 15 homolog; tRNA-splicing endonuclease subunit Sen15 isoform 1; tRNA-splicing endonuclease subunit Sen15", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 2F (Disease Ontology:DOID:0112329)", "pathway": " (rno:289083)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000214 tRNA-intron endonuclease complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K1V3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K283-1", "uniprot_id": [ { "id": "A0A0G2K283_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K283", "type": "external" } ], "mass": 142576.0, "length": 1244, "protein_name": "ATP-dependent RNA helicase DHX8", "gene_name": "Dhx8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dhx8", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX8; 3.6.4.13; DEAH box protein 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-72163)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. 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Secreted apoptosis-related protein 1", "protein_names_refseq": "secreted frizzled-related protein 2 precursor", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:310552)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "27113532;30291843;31918758;38101654", "class_list": "", "function": "IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy., [RefSeq, PubMed]; Sfrp2 shows itself to be a therapeutic target for the prevention of irreversible fibrosis., [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis., [UniProtKB, UniProtKB]; Wnt signaling was activated in the nucleus accumbens of rats suffering from morphine withdrawal and that Sfrp2 attenuated the overexpression of Wnt signaling. Similarly, the withdrawal-like symptoms of morphine dependent rats were abrogated by intracerebral Sfrp2 injection. Damage on proximal spine density caused by morphine treatment was restored by intracerebral Sfrp2 injection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008047 enzyme activator activity;GO:0017147 Wnt-protein binding;GO:0061133 endopeptidase activator activity;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1WBV2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV15-1", "uniprot_id": [ { "id": "B2GV15_RAT", "url": "https://www.uniprot.org/uniprot/B2GV15", "type": "external" } ], "mass": 53274.0, "length": 482, "protein_name": "Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex", "gene_name": "Dbt", "organism": "Rat", "refseq_name": "lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "refseq_ac": [ { "id": "NP_445764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445764", "type": "external" } ], "gene_names_uniprotkb": "Dbt", "gene_names_refseq": "Dbt", "protein_names_uniprotkb": "Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; 2.3.1.-", "protein_names_refseq": "lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial", "tax_id": 10116, "disease": "maple syrup urine disease type II (Disease Ontology:DOID:0061207); maple syrup urine disease (Disease Ontology:DOID:9269)", "pathway": " (rno:29611); (R-RNO-70895); (R-RNO-9013407); (R-RNO-9837999); (R-RNO-9857492); (R-RNO-9859138)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.200", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0043754 dihydrolipoamide branched chain acyltransferase activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0042645 mitochondrial nucleoid;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV15-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV72-1", "uniprot_id": [ { "id": "CRB3_RAT", "url": "https://www.uniprot.org/uniprot/B2GV72", "type": "external" } ], "mass": 30841.0, "length": 277, "protein_name": "Carbonyl reductase [NADPH] 3", "gene_name": "Cbr3", "organism": "Rat", "refseq_name": "carbonyl reductase [NADPH] 3", "refseq_ac": [ { "id": "NP_001100580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100580", "type": "external" } ], "gene_names_uniprotkb": "Cbr3", "gene_names_refseq": "Cbr3", "protein_names_uniprotkb": "Carbonyl reductase [NADPH] 3; 1.1.1.184; 1.6.5.10; Monomeric carbonyl reductase 3; Quinone reductase CBR3", "protein_names_refseq": "carbonyl reductase [NADPH] 3; monomeric carbonyl reductase 3; quinone reductase CBR3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:304078); (R-RNO-211945)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18983987", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. Has low NADPH-dependent oxidoreductase activity (PubMed:18983987). Acts on several orthoquinones, as well as on non-quinone compounds, such as isatin or on the anticancer drug oracin. Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones. Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0050890 cognition;GO:0042376 phylloquinone catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GV72-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV96-1", "uniprot_id": [ { "id": "B2GV96_RAT", "url": "https://www.uniprot.org/uniprot/B2GV96", "type": "external" } ], "mass": 19815.0, "length": 180, "protein_name": "Vacuolar ATPase assembly protein VMA22", "gene_name": "Vma22", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 115", "refseq_ac": [ { "id": "NP_001102263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102263", "type": "external" } ], "gene_names_uniprotkb": "Vma22; Ccdc115", "gene_names_refseq": "Ccdc115; RGD1304653; Vma22", "protein_names_uniprotkb": "Vacuolar ATPase assembly protein VMA22; Coiled-coil domain-containing protein 115", "protein_names_refseq": "coiled-coil domain containing 115; coiled-coil domain-containing protein 115", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIo (Disease Ontology:DOID:0070267)", "pathway": " (rno:363213); (R-RNO-8980692)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007042 lysosomal lumen acidification;GO:0036295 cellular response to increased oxygen levels;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV96-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GVC0-1", "uniprot_id": [ { "id": "B2GVC0_RAT", "url": "https://www.uniprot.org/uniprot/B2GVC0", "type": "external" } ], "mass": 21602.0, "length": 193, "protein_name": "p53 apoptosis effector related to PMP-22", "gene_name": "Perp", "organism": "Rat", "refseq_name": "p53 apoptosis effector related to PMP-22", "refseq_ac": [ { "id": "NP_001099735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099735", "type": "external" } ], "gene_names_uniprotkb": "Perp", "gene_names_refseq": "Perp", "protein_names_uniprotkb": "p53 apoptosis effector related to PMP-22; Keratinocyte-associated protein 1", "protein_names_refseq": "PERP, TP53 apoptosis effector; p53 apoptosis effector related to PMP-22", "tax_id": 10116, "disease": "erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112011)", "pathway": " (rno:292949); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0007219 Notch signaling pathway;GO:0001894 tissue homeostasis;GO:0098609 cell-cell adhesion;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GVC0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYM9-1", "uniprot_id": [ { "id": "B2RYM9_RAT", "url": "https://www.uniprot.org/uniprot/B2RYM9", "type": "external" } ], "mass": 40332.0, "length": 364, "protein_name": "Solute carrier family 35 member C2", "gene_name": "Slc35c2", "organism": "Rat", "refseq_name": "solute carrier family 35 member C2 isoform a", "refseq_ac": [ { "id": "NP_001101273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101273", "type": "external" } ], "gene_names_uniprotkb": "Slc35c2", "gene_names_refseq": "Slc35c2", "protein_names_uniprotkb": "Solute carrier family 35 member C2", "protein_names_refseq": "solute carrier family 35 (GDP-fucose transporter), member C2; solute carrier family 35 member C2 isoform a", "tax_id": 10116, "disease": "", "pathway": " (rno:311637)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0045747 positive regulation of Notch signaling pathway;GO:0036066 protein O-linked glycosylation via fucose;GO:0015786 UDP-glucose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYN0-1", "uniprot_id": [ { "id": "B2RYN0_RAT", "url": "https://www.uniprot.org/uniprot/B2RYN0", "type": "external" } ], "mass": 59685.0, "length": 542, "protein_name": "Phosphoacetylglucosamine mutase", "gene_name": "Pgm3", "organism": "Rat", "refseq_name": "phosphoacetylglucosamine mutase", "refseq_ac": [ { "id": "NP_001388122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388122", "type": "external" } ], "gene_names_uniprotkb": "Pgm3", "gene_names_refseq": "Pgm3", "protein_names_uniprotkb": "Phosphoacetylglucosamine mutase; 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; PAGM", "protein_names_refseq": "phosphoacetylglucosamine mutase", "tax_id": 10116, "disease": "immunodeficiency 23 (Disease Ontology:DOID:0111953); cancer (Disease Ontology:DOID:162); teratoma (Disease Ontology:DOID:3307); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:363109); (R-RNO-446210)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZFX4", "ec_number_list": [ { "id": "5.4.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.3", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004610 phosphoacetylglucosamine mutase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030097 hemopoiesis;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0007283 spermatogenesis;GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYN0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ44-1", "uniprot_id": [ { "id": "B2RZ44_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ44", "type": "external" } ], "mass": 20368.0, "length": 178, "protein_name": "N-alpha-acetyltransferase 20", "gene_name": "Naa20", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 20 isoform b", "refseq_ac": [ { "id": "NP_001421284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421284", "type": "external" } ], "gene_names_uniprotkb": "Naa20", "gene_names_refseq": "Naa20; Nat5", "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit", "protein_names_refseq": "N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae); N-alpha-acetyltransferase 20 isoform b", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)", "pathway": " (rno:362228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.254", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254", "type": "external" } ], "go_molecular_function": "GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031416 NatB complex", "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation;GO:0017192 N-terminal peptidyl-glutamine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZ44-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F778-1", "uniprot_id": [ { "id": "B4F778_RAT", "url": "https://www.uniprot.org/uniprot/B4F778", "type": "external" } ], "mass": 39957.0, "length": 364, "protein_name": "Replication factor C subunit 4", "gene_name": "Rfc4", "organism": "Rat", "refseq_name": "replication factor C subunit 4", "refseq_ac": [ { "id": "NP_001099339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099339", "type": "external" } ], "gene_names_uniprotkb": "Rfc4", "gene_names_refseq": "Rfc4", "protein_names_uniprotkb": "Replication factor C subunit 4; Activator 1 subunit 4", "protein_names_refseq": "replication factor C (activator 1) 4; replication factor C subunit 4", "tax_id": 10116, "disease": "", "pathway": " (rno:288003); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-174411); (R-RNO-176187); (R-RNO-5651801); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693607); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6804756); (R-RNO-69091); (R-RNO-69473)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F778-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7C7-1", "uniprot_id": [ { "id": "B4F7C7_RAT", "url": "https://www.uniprot.org/uniprot/B4F7C7", "type": "external" } ], "mass": 21124.0, "length": 190, "protein_name": "Heme-binding protein 1", "gene_name": "Hebp1", "organism": "Rat", "refseq_name": "heme-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001385805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385805", "type": "external" } ], "gene_names_uniprotkb": "Hebp1", "gene_names_refseq": "Hebp1", "protein_names_uniprotkb": "Heme-binding protein 1; p22HBP", "protein_names_refseq": "heme-binding protein 1 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362454); (R-RNO-418594); (R-RNO-444473)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F7EVC6", "ec_number_list": [], "go_molecular_function": "GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F7C7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7E7-1", "uniprot_id": [ { "id": "PALS1_RAT", "url": "https://www.uniprot.org/uniprot/B4F7E7", "type": "external" } ], "mass": 77152.0, "length": 675, "protein_name": "Protein PALS1", "gene_name": "Pals1", "organism": "Rat", "refseq_name": "protein PALS1", "refseq_ac": [ { "id": "NP_001101504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101504", "type": "external" } ], "gene_names_uniprotkb": "Pals1; Mpp5", "gene_names_refseq": "Mpp5; Pals1", "protein_names_uniprotkb": "Protein PALS1; MAGUK p55 subfamily member 5; Protein associated with Lin-7 1", "protein_names_refseq": "MAGUK p55 subfamily member 5; membrane palmitoylated protein 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); protein PALS1; protein associated with LIN7 1, MAGUK family member; protein associated with Lin-7 1", "tax_id": 10116, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:314259)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20237282;22673903", "class_list": "", "function": "Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (PubMed:20237282). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0016332 establishment or maintenance of polarity of embryonic epithelium;GO:0007009 plasma membrane organization;GO:0072659 protein localization to plasma membrane;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B4F7E7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEJ6-1", "uniprot_id": [ { "id": "B5DEJ6_RAT", "url": "https://www.uniprot.org/uniprot/B5DEJ6", "type": "external" } ], "mass": 27207.0, "length": 243, "protein_name": "Thiamine pyrophosphokinase", "gene_name": "Tpk1", "organism": "Rat", "refseq_name": "thiamin pyrophosphokinase 1", "refseq_ac": [ { "id": "NP_001128466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128466", "type": "external" } ], "gene_names_uniprotkb": "Tpk1", "gene_names_refseq": "Tpk1", "protein_names_uniprotkb": "Thiamine pyrophosphokinase; 2.7.6.2", "protein_names_refseq": "thiamin pyrophosphokinase 1; thiamine pyrophosphokinase", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (rno:680668); (R-RNO-196819)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQE3", "ec_number_list": [ { "id": "2.7.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016301 kinase activity;GO:0004788 thiamine diphosphokinase activity;GO:0030975 thiamine binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEJ6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEZ6-1", "uniprot_id": [ { "id": "B5DEZ6_RAT", "url": "https://www.uniprot.org/uniprot/B5DEZ6", "type": "external" } ], "mass": 30836.0, "length": 274, "protein_name": "Glucosamine-6-phosphate deaminase 2", "gene_name": "Gnpda2", "organism": "Rat", "refseq_name": "glucosamine-6-phosphate isomerase 2 isoform X1", "refseq_ac": [ { "id": "XP_006251098", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251098", "type": "external" } ], "gene_names_uniprotkb": "Gnpda2", "gene_names_refseq": "Gnpda2", "protein_names_uniprotkb": "Glucosamine-6-phosphate deaminase 2; 3.5.99.6; Glucosamine-6-phosphate isomerase 2", "protein_names_refseq": "glucosamine-6-phosphate isomerase 2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:289608); (R-RNO-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.99.6", "type": "external" } ], "go_molecular_function": "GO:0004342 glucosamine-6-phosphate deaminase activity;GO:0042802 identical protein binding;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006043 glucosamine catabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0005975 carbohydrate metabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFC3-1", "uniprot_id": [ { "id": "B5DFC3_RAT", "url": "https://www.uniprot.org/uniprot/B5DFC3", "type": "external" } ], "mass": 86162.0, "length": 765, "protein_name": "Protein transport protein SEC23", "gene_name": "Sec23a", "organism": "Rat", "refseq_name": "protein transport protein Sec23A isoform 1", "refseq_ac": [ { "id": "NP_001099202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099202", "type": "external" } ], "gene_names_uniprotkb": "Sec23a", "gene_names_refseq": "Sec23a", "protein_names_uniprotkb": "Protein transport protein SEC23", "protein_names_refseq": "Sec23 homolog A, COPII coat complex component; Sec23 homolog A, coat complex II component; protein transport protein Sec23A isoform 1; protein transport protein Sec23A", "tax_id": 10116, "disease": "craniolenticulosutural dysplasia (Disease Ontology:DOID:0070307); congenital dyserythropoietic anemia type II (Disease Ontology:DOID:0111401); Roberts syndrome (Disease Ontology:DOID:5325)", "pathway": " (rno:58817); (R-RNO-204005); (R-RNO-2132295); (R-RNO-5694530); (R-RNO-983170)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "28801610;38843836", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules., [UniProtKB, UniProtKB, UniProtKB]; Sec23A expression is upregulated via CREB3L2 during hepatic stellate cells activation. Sec23A knockdown abrogated the activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane;GO:0090114 COPII-coated vesicle budding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B5DFC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFG6-1", "uniprot_id": [ { "id": "B5DFG6_RAT", "url": "https://www.uniprot.org/uniprot/B5DFG6", "type": "external" } ], "mass": 29553.0, "length": 262, "protein_name": "Carbonic anhydrase", "gene_name": "Ca13", "organism": "Rat", "refseq_name": "carbonic anhydrase 13", "refseq_ac": [ { "id": "NP_001128465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128465", "type": "external" } ], "gene_names_uniprotkb": "Ca13; Car13", "gene_names_refseq": "Ca13; Car13; RGD1560453", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 13; carbonic anhydrase XIII", "tax_id": 10116, "disease": "", "pathway": " (rno:499566); (R-RNO-1475029)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DFG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFG8-1", "uniprot_id": [ { "id": "B5DFG8_RAT", "url": "https://www.uniprot.org/uniprot/B5DFG8", "type": "external" } ], "mass": 41084.0, "length": 405, "protein_name": "Pygopus family PHD finger 2", "gene_name": "Pygo2", "organism": "Rat", "refseq_name": "pygopus homolog 2", "refseq_ac": [ { "id": "NP_001099917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099917", "type": "external" } ], "gene_names_uniprotkb": "Pygo2", "gene_names_refseq": "Pygo2; RGD1308535", "protein_names_uniprotkb": "Pygopus family PHD finger 2", "protein_names_refseq": "pygopus 2; pygopus homolog 2", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (rno:295251); (R-RNO-201722); (R-RNO-3769402)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20361361;22673903", "class_list": "", "function": "Involved in signal transduction through the Wnt pathway., [UniProtKB, UniProtKB]; Pygo2 is highly expressed in and promotes the growth of glioma cells by, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0035034 histone acetyltransferase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0001822 kidney development;GO:0007286 spermatid development;GO:0007420 brain development;GO:0060021 roof of mouth development;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B5DFG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8A4-1", "uniprot_id": [ { "id": "D3Z8A4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8A4", "type": "external" } ], "mass": 111917.0, "length": 1011, "protein_name": "TRPM8 channel-associated factor 1", "gene_name": "Tcaf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tcaf1; Fam115a", "gene_names_refseq": "", "protein_names_uniprotkb": "TRPM8 channel-associated factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZFL9", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0090314 positive regulation of protein targeting to membrane;GO:1901529 positive regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z8A4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8B6-1", "uniprot_id": [ { "id": "D3Z8B6_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8B6", "type": "external" } ], "mass": 51286.0, "length": 459, "protein_name": "Protein ABHD15", "gene_name": "Abhd15", "organism": "Rat", "refseq_name": "protein ABHD15 precursor", "refseq_ac": [ { "id": "NP_001100495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100495", "type": "external" } ], "gene_names_uniprotkb": "Abhd15", "gene_names_refseq": "Abhd15; RGD1304598", "protein_names_uniprotkb": "Protein ABHD15; Alpha/beta hydrolase domain-containing protein 15", "protein_names_refseq": "abhydrolase domain-containing protein 15; alpha/beta hydrolase-1; lung alpha/beta hydrolase 1; protein ABHD15 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:303343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate adipocyte lipolysis and liver lipid accumulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0034338 short-chain carboxylesterase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0060612 adipose tissue development;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z8B6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8C4-1", "uniprot_id": [ { "id": "D3Z8C4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8C4", "type": "external" } ], "mass": 98983.0, "length": 889, "protein_name": "Protein MCM10 homolog", "gene_name": "Mcm10", "organism": "Rat", "refseq_name": "protein MCM10 homolog", "refseq_ac": [ { "id": "NP_001100836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100836", "type": "external" } ], "gene_names_uniprotkb": "Mcm10", "gene_names_refseq": "Mcm10", "protein_names_uniprotkb": "Protein MCM10 homolog", "protein_names_refseq": "minichromosome maintenance complex component 10; minichromosome maintenance deficient 10; protein MCM10 homolog", "tax_id": 10116, "disease": "immunodeficiency 80 (Disease Ontology:DOID:0061051)", "pathway": " (rno:307126); (R-RNO-176187); (R-RNO-68962)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0008283 cell population proliferation;GO:0006974 DNA damage response;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8C9-1", "uniprot_id": [ { "id": "PDE6A_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8C9", "type": "external" } ], "mass": 99752.0, "length": 860, "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "gene_name": "Pde6a", "organism": "Rat", "refseq_name": "rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "refseq_ac": [ { "id": "NP_001100856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100856", "type": "external" } ], "gene_names_uniprotkb": "Pde6a", "gene_names_refseq": "Pde6a", "protein_names_uniprotkb": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; 3.1.4.35", "protein_names_refseq": "phosphodiesterase 6A, cGMP-specific, rod, alpha; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "tax_id": 10116, "disease": "retinitis pigmentosa 43 (Disease Ontology:DOID:0110379); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:307401); (R-RNO-2485179); (R-RNO-2514859); (R-RNO-4086398)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "1309771", "class_list": "", "function": "Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (By similarity). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8D1-1", "uniprot_id": [ { "id": "D3Z8D1_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8D1", "type": "external" } ], "mass": 40576.0, "length": 369, "protein_name": "SIGLEC family like 1", "gene_name": "Siglecl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Siglecl1; 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Fam86a", "gene_names_refseq": "Eef2kmt; Fam86a; RGD1304969", "protein_names_uniprotkb": "Eukaryotic elongation factor 2 lysine methyltransferase", "protein_names_refseq": "family with sequence similarity 86, member A; protein-lysine N-methyltransferase EEF2KMT", "tax_id": 10116, "disease": "", "pathway": " (rno:302931); (R-RNO-8876725)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0018023 peptidyl-lysine trimethylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8P8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8U4-1", "uniprot_id": [ { "id": "D3Z8U4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8U4", "type": "external" } ], "mass": 16323.0, "length": 145, "protein_name": "LY6/PLAUR domain containing 9", "gene_name": "Lypd9", "organism": "Rat", "refseq_name": "uncharacterized protein LOC691286 isoform 1", "refseq_ac": [ { "id": "NP_001103104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103104", "type": "external" } ], "gene_names_uniprotkb": "Lypd9; 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The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex. The GATOR2 complex is required for brain myelination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032289 central nervous system myelin formation;GO:0031669 cellular response to nutrient levels;GO:0034198 cellular response to amino acid starvation;GO:0031503 protein-containing complex localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9C0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9E9-1", "uniprot_id": [ { "id": "D3Z9E9_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9E9", "type": "external" } ], "mass": 39270.0, "length": 353, "protein_name": "Cell cycle control protein", "gene_name": "Tmem30b", "organism": "Rat", "refseq_name": "cell cycle control protein 50B", "refseq_ac": [ { "id": "NP_001073849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073849", "type": "external" } ], "gene_names_uniprotkb": "Tmem30b", "gene_names_refseq": "Cdc50b; Tmem30b", "protein_names_uniprotkb": "Cell cycle control protein", "protein_names_refseq": "cell cycle control protein 50B; transmembrane protein 30B", "tax_id": 10116, "disease": "", "pathway": " (rno:314224)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:1990531 phospholipid-translocating ATPase complex", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0070863 positive regulation of protein exit from endoplasmic reticulum;GO:0015917 aminophospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9E9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9F9-1", "uniprot_id": [ { "id": "D3Z9F9_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9F9", "type": "external" } ], "mass": 37336.0, "length": 339, "protein_name": "Sperm acrosome associated 1", "gene_name": "Spaca1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spaca1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm acrosome associated 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 85 (Disease Ontology:DOID:0070584)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9F9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9I4-1", "uniprot_id": [ { "id": "D3Z9I4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9I4", "type": "external" } ], "mass": 24438.0, "length": 216, "protein_name": "DNA replication complex GINS protein PSF3", "gene_name": "Gins3", "organism": "Rat", "refseq_name": "DNA replication complex GINS protein PSF3", "refseq_ac": [ { "id": "NP_001100878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100878", "type": "external" } ], "gene_names_uniprotkb": "Gins3", "gene_names_refseq": "Gins3; RGD1308153", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF3", "protein_names_refseq": "DNA replication complex GINS protein PSF3; GINS complex subunit 3 (Psf3 homolog)", "tax_id": 10116, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306)", "pathway": " (rno:307639); (R-RNO-176974)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB, UniProtKB]; The GINS complex plays an essential role in the initiation of DNA replication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0035264 multicellular organism growth;GO:0006260 DNA replication;GO:0090398 cellular senescence;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9I4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9K1-1", "uniprot_id": [ { "id": "D3Z9K1_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9K1", "type": "external" } ], "mass": 54284.0, "length": 492, "protein_name": "Transmembrane protein 200A", "gene_name": "Tmem200a", "organism": "Rat", "refseq_name": "transmembrane protein 200A isoform 2", "refseq_ac": [ { "id": "XP_063126553", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063126553", "type": "external" } ], "gene_names_uniprotkb": "Tmem200a", "gene_names_refseq": "RGD1564024; Tmem200a", "protein_names_uniprotkb": "Transmembrane protein 200A", "protein_names_refseq": "transmembrane protein 200A isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:498987)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9K1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9Z1-1", "uniprot_id": [ { "id": "D3Z9Z1_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9Z1", "type": "external" } ], "mass": 52994.0, "length": 490, "protein_name": "Otoconin-90", "gene_name": "Oc90", "organism": "Rat", "refseq_name": "otoconin-90 precursor", "refseq_ac": [ { "id": "NP_001128237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128237", "type": "external" } ], "gene_names_uniprotkb": "Oc90", "gene_names_refseq": "Oc90", "protein_names_uniprotkb": "Otoconin-90", "protein_names_refseq": "otoconin-90 precursor; otoconin-90-like", "tax_id": 10116, "disease": "", "pathway": " (rno:690625)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34403090", "class_list": "", "function": "Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity., [UniProtKB, UniProtKB]; Molecular Mediators of Estrogen Reduction-induced Otolith Shedding., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005198 structural molecule activity;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process;GO:0045299 otolith mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA31-1", "uniprot_id": [ { "id": "D3ZA31_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA31", "type": "external" } ], "mass": 65780.0, "length": 571, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2", "gene_name": "Mtmr2", "organism": "Rat", "refseq_name": "myotubularin-related protein 2 isoform X1", "refseq_ac": [ { "id": "XP_006242584", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006242584", "type": "external" } ], "gene_names_uniprotkb": "Mtmr2", "gene_names_refseq": "Mtmr2", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; 3.1.3.95; Myotubularin-related protein 2; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "myotubularin-related protein 2 isoform X1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 4B1 (Disease Ontology:DOID:0110191); centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); myopathy (Disease Ontology:DOID:423)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052866 phosphatidylinositol phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030424 axon", "go_biological_process": "GO:0016311 dephosphorylation;GO:0045806 negative regulation of endocytosis;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0048666 neuron development;GO:0002091 negative regulation of receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZA31-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA32-1", "uniprot_id": [ { "id": "D3ZA32_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA32", "type": "external" } ], "mass": 49814.0, "length": 446, "protein_name": "Gasdermin A", "gene_name": "Gsdma", "organism": "Rat", "refseq_name": "gasdermin-A", "refseq_ac": [ { "id": "NP_001101767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101767", "type": "external" } ], "gene_names_uniprotkb": "Gsdma", "gene_names_refseq": "Gsdma1; Gsdma", "protein_names_uniprotkb": "Gasdermin A", "protein_names_refseq": "gasdermin A1; gasdermin-A", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:360619)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZA32-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA38-1", "uniprot_id": [ { "id": "D3ZA38_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA38", "type": "external" } ], "mass": 127949.0, "length": 1143, "protein_name": "Myosin-binding protein C, fast-type", "gene_name": "Mybpc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mybpc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin-binding protein C, fast-type; C-protein, skeletal muscle fast isoform", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); myopathy (Disease Ontology:DOID:423)", "pathway": " (R-RNO-390522)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008307 structural constituent of muscle;GO:0003779 actin binding", "go_cellular_component": "GO:0031430 M band;GO:0032982 myosin filament", "go_biological_process": "GO:0045214 sarcomere organization;GO:0007155 cell adhesion;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZA38-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAE3-1", "uniprot_id": [ { "id": "D3ZAE3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAE3", "type": "external" } ], "mass": 66593.0, "length": 585, "protein_name": "DENN domain containing 6B", "gene_name": "Dennd6b", "organism": "Rat", "refseq_name": "protein DENND6B", "refseq_ac": [ { "id": "NP_001102219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102219", "type": "external" } ], "gene_names_uniprotkb": "Dennd6b", "gene_names_refseq": "Dennd6b; Fam116b; RGD1308012", "protein_names_uniprotkb": "DENN domain containing 6B", "protein_names_refseq": "DENN/MADD domain containing 6B; family with sequence similarity 116, member B; hypothetical protein MGC38041; protein DENND6B; protein FAM116B", "tax_id": 10116, "disease": "", "pathway": " (rno:362983); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0055037 recycling endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAG6-1", "uniprot_id": [ { "id": "D3ZAG6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAG6", "type": "external" } ], "mass": 31959.0, "length": 282, "protein_name": "Limb and CNS expressed 1", "gene_name": "Lix1", "organism": "Rat", "refseq_name": "protein limb expression 1 homolog", "refseq_ac": [ { "id": "NP_001099684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099684", "type": "external" } ], "gene_names_uniprotkb": "Lix1", "gene_names_refseq": "Lix1", "protein_names_uniprotkb": "Limb and CNS expressed 1", "protein_names_refseq": "Lix1 homolog; limb expression 1 homolog; protein limb expression 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097352 autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAM6-1", "uniprot_id": [ { "id": "D3ZAM6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAM6", "type": "external" } ], "mass": 37290.0, "length": 345, "protein_name": "Transmembrane protein 198", "gene_name": "Tmem198b", "organism": "Rat", "refseq_name": "uncharacterized protein LOC500762", "refseq_ac": [ { "id": "NP_001102751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102751", "type": "external" } ], "gene_names_uniprotkb": "Tmem198b", "gene_names_refseq": "RGD1562342; Tmem198b", "protein_names_uniprotkb": "Transmembrane protein 198", "protein_names_refseq": "uncharacterized protein LOC500762", "tax_id": 10116, "disease": "", "pathway": " (rno:500762)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAP1-1", "uniprot_id": [ { "id": "D3ZAP1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAP1", "type": "external" } ], "mass": 26321.0, "length": 244, "protein_name": "Mediator of RNA polymerase II transcription subunit 19", "gene_name": "Med19", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 19", "refseq_ac": [ { "id": "NP_001101211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101211", "type": "external" } ], "gene_names_uniprotkb": "Med19; 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Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB]; Hypoxic Bone Mesenchymal Stem Cell-Derived Exosomes Direct Schwann Cells Proliferation, Migration, and Paracrine to Accelerate Facial Nerve Regeneration via circRNA_Nkd2/miR-214-3p/MED19 Axis. 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Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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LOC679739; Ndufs6l1", "gene_names_refseq": "Ndufs6l1; Ndufs6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH:ubiquinone oxidoreductase subunit S6-like 1", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 9 (Disease Ontology:DOID:0112073); cervical cancer (Disease Ontology:DOID:4362)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A096MK72", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0072359 circulatory system development;GO:0097168 mesenchymal stem cell proliferation;GO:0006631 fatty acid metabolic process;GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCZ9-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD07-1", "uniprot_id": [ { "id": "D3ZD07_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD07", "type": "external" } ], "mass": 61971.0, "length": 543, "protein_name": "Flavin-containing monooxygenase", "gene_name": "Fmo9", "organism": "Rat", "refseq_name": "flavin containing monooxygenase 9", "refseq_ac": [ { "id": "NP_001102936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102936", "type": "external" } ], "gene_names_uniprotkb": "Fmo9", "gene_names_refseq": "Fmo9p; Fmo9", "protein_names_uniprotkb": "Flavin-containing monooxygenase; 1.-.-.-", "protein_names_refseq": "flavin containing monooxygenase 9 pseudogene; flavin containing monooxygenase 9", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (rno:685365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZD07-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD62-1", "uniprot_id": [ { "id": "D3ZD62_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD62", "type": "external" } ], "mass": 101067.0, "length": 883, "protein_name": "[heparan sulfate]-glucosamine N-sulfotransferase", "gene_name": "Ndst2", "organism": "Rat", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2", "refseq_ac": [ { "id": "NP_001099210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099210", "type": "external" } ], "gene_names_uniprotkb": "Ndst2", "gene_names_refseq": "Ndst2", "protein_names_uniprotkb": "[heparan sulfate]-glucosamine N-sulfotransferase; 2.8.2.8", "protein_names_refseq": "N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; N-deacetylase/N-sulfotransferase 2; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994)", "pathway": " (rno:114002); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0030210 heparin proteoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0002448 mast cell mediated immunity;GO:0002002 regulation of angiotensin levels in blood", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZD62-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD73-1", "uniprot_id": [ { "id": "D3ZD73_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD73", "type": "external" } ], "mass": 54245.0, "length": 483, "protein_name": "Probable ATP-dependent RNA helicase DDX6", "gene_name": "Ddx6", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX6", "refseq_ac": [ { "id": "NP_001102762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102762", "type": "external" } ], "gene_names_uniprotkb": "Ddx6", "gene_names_refseq": "Ddx6; RGD1564560", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; DEAD box protein 6; Oncogene RCK homolog; Probable ATP-dependent RNA helicase ddx6", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; probable ATP-dependent RNA helicase DDX6", "tax_id": 10116, "disease": "", "pathway": " (rno:500988); (R-RNO-430039)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0097227 sperm annulus;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019074 viral RNA genome packaging;GO:0007283 spermatogenesis;GO:0045665 negative regulation of neuron differentiation;GO:0017148 negative regulation of translation;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZD73-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDZ2-1", "uniprot_id": [ { "id": "D3ZDZ2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDZ2", "type": "external" } ], "mass": 30814.0, "length": 288, "protein_name": "Membrane spanning 4-domains A8", "gene_name": "Ms4a8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ms4a8", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane spanning 4-domains A8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDZ2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE86-1", "uniprot_id": [ { "id": "D3ZE86_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE86", "type": "external" } ], "mass": 47574.0, "length": 422, "protein_name": "Leucine-rich repeat protein 1", "gene_name": "Lrr1", "organism": "Rat", "refseq_name": "leucine-rich repeat protein 1", "refseq_ac": [ { "id": "NP_001102953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102953", "type": "external" } ], "gene_names_uniprotkb": "Lrr1", "gene_names_refseq": "Lrr1; Ppil5", "protein_names_uniprotkb": "Leucine-rich repeat protein 1", "protein_names_refseq": "leucine-rich repeat protein 1; peptidylprolyl isomerase (cyclophilin) like 5; peptidylprolyl isomerase-like 5", "tax_id": 10116, "disease": "", "pathway": " (rno:685860); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZE86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEH7-1", "uniprot_id": [ { "id": "D3ZEH7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEH7", "type": "external" } ], "mass": 26631.0, "length": 238, "protein_name": "Transmembrane protein 150B", "gene_name": "Tmem150b", "organism": "Rat", "refseq_name": "modulator of macroautophagy TMEM150B", "refseq_ac": [ { "id": "NP_001100946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100946", "type": "external" } ], "gene_names_uniprotkb": "Tmem150b", "gene_names_refseq": "RGD1306181; Tmem150b; Tmem224", "protein_names_uniprotkb": "Transmembrane protein 150B", "protein_names_refseq": "modulator of macroautophagy TMEM150B; transmembrane protein 224", "tax_id": 10116, "disease": "", "pathway": " (rno:308346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFB0-1", "uniprot_id": [ { "id": "D3ZFB0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFB0", "type": "external" } ], "mass": 13970.0, "length": 126, "protein_name": "Golgi transport 1A", "gene_name": "Golt1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Golt1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi transport 1A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in fusion of ER-derived transport vesicles with the Golgi complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFB0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFD3-1", "uniprot_id": [ { "id": "D3ZFD3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFD3", "type": "external" } ], "mass": 16973.0, "length": 157, "protein_name": "Dynactin associated protein-like 1", "gene_name": "Dynapl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dynapl1; Dynap; LOC102552939", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynactin associated protein-like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFD3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFG5-1", "uniprot_id": [ { "id": "D3ZFG5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFG5", "type": "external" } ], "mass": 14952.0, "length": 132, "protein_name": "Myelin P2 protein", "gene_name": "Pmp2", "organism": "Rat", "refseq_name": "myelin P2 protein", "refseq_ac": [ { "id": "NP_001102984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102984", "type": "external" } ], "gene_names_uniprotkb": "Pmp2", "gene_names_refseq": "Pmp2", "protein_names_uniprotkb": "Myelin P2 protein", "protein_names_refseq": "myelin P2 protein", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 1G (Disease Ontology:DOID:0111560)", "pathway": " (rno:688790)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May play a role in lipid transport protein in Schwann cells. May bind cholesterol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0061024 membrane organization;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZFG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFH4-1", "uniprot_id": [ { "id": "D3ZFH4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFH4", "type": "external" } ], "mass": 22565.0, "length": 194, "protein_name": "RD3 like", "gene_name": "Rd3l", "organism": "Rat", "refseq_name": "protein RD3-like", "refseq_ac": [ { "id": "NP_001128032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128032", "type": "external" } ], "gene_names_uniprotkb": "Rd3l; RGD1305627", "gene_names_refseq": "RGD1305627; Rd3l", "protein_names_uniprotkb": "RD3 like", "protein_names_refseq": "protein RD3-like; retinal degeneration 3-like", "tax_id": 10116, "disease": "", "pathway": " (rno:314467)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFM1-1", "uniprot_id": [ { "id": "D3ZFM1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFM1", "type": "external" } ], "mass": 34446.0, "length": 321, "protein_name": "Anti-silencing function 1A histone chaperone", "gene_name": "Asf1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Asf1a", "gene_names_refseq": "", "protein_names_uniprotkb": "Anti-silencing function 1A histone chaperone", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-2559584)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006334 nucleosome assembly;GO:0001649 osteoblast differentiation;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZFM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFP7-1", "uniprot_id": [ { "id": "D3ZFP7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFP7", "type": "external" } ], "mass": 63783.0, "length": 579, "protein_name": "Protein inscuteable homolog", "gene_name": "Insc", "organism": "Rat", "refseq_name": "protein inscuteable homolog", "refseq_ac": [ { "id": "NP_001099755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099755", "type": "external" } ], "gene_names_uniprotkb": "Insc", "gene_names_refseq": "Insc; RGD1311379", "protein_names_uniprotkb": "Protein inscuteable homolog", "protein_names_refseq": "inscuteable homolog; protein inscuteable homolog", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539)", "pathway": " (rno:293166)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009786 regulation of asymmetric cell division;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability;GO:0008356 asymmetric cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFP7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFQ7-1", "uniprot_id": [ { "id": "D3ZFQ7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFQ7", "type": "external" } ], "mass": 28378.0, "length": 252, "protein_name": "Spermatogenesis associated 9", "gene_name": "Spata9", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 9", "refseq_ac": [ { "id": "NP_001099869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099869", "type": "external" } ], "gene_names_uniprotkb": "Spata9", "gene_names_refseq": "Spata9", "protein_names_uniprotkb": "Spermatogenesis associated 9", "protein_names_refseq": "spermatogenesis-associated protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:294594)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZFQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFE0-1", "uniprot_id": [ { "id": "B5DFE0_RAT", "url": "https://www.uniprot.org/uniprot/B5DFE0", "type": "external" } ], "mass": 64006.0, "length": 566, "protein_name": "MAGUK p55 subfamily member 2", "gene_name": "Pals2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pals2; Mpp6", "gene_names_refseq": "", "protein_names_uniprotkb": "MAGUK p55 subfamily member 2; Protein MPP2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362359)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZW03", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DFE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AKY7-1", "uniprot_id": [ { "id": "A0A8I6AKY7_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AKY7", "type": "external" } ], "mass": 62862.0, "length": 555, "protein_name": "Butyrophilin, subfamily 2, member A2", "gene_name": "Btn2a2", "organism": "Rat", "refseq_name": "butyrophilin subfamily 2 member A2 isoform X1", "refseq_ac": [ { "id": "XP_063132510", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063132510", "type": "external" } ], "gene_names_uniprotkb": "Btn2a2", "gene_names_refseq": "Btn2a2", "protein_names_uniprotkb": "Butyrophilin, subfamily 2, member A2", "protein_names_refseq": "butyrophilin subfamily 2 member A2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:306957); (R-RNO-8851680)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane;GO:0009986 cell surface", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0001817 regulation of cytokine production;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AKY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AL96-1", "uniprot_id": [ { "id": "A0A8I6AL96_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AL96", "type": "external" } ], "mass": 113386.0, "length": 1031, "protein_name": "Delphilin", "gene_name": "Grid2ip", "organism": "Rat", "refseq_name": "delphilin isoform 2", "refseq_ac": [ { "id": "NP_001402708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402708", "type": "external" } ], "gene_names_uniprotkb": "Grid2ip", "gene_names_refseq": "Grid2ip", "protein_names_uniprotkb": "Delphilin; Glutamate receptor, ionotropic, delta 2-interacting protein 1", "protein_names_refseq": "delphilin isoform 2; delphilin; glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288484)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16781059;22673903", "class_list": "", "function": "Group II mGluRs may play a significant role in regulating dopamine release in the nucleus accumbens., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0099092 postsynaptic density, intracellular component;GO:0098688 parallel fiber to Purkinje cell synapse;GO:0150048 cerebellar granule cell to Purkinje cell synapse;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A8I6AL96-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XT9-1", "uniprot_id": [ { "id": "ASAH2_RAT", "url": "https://www.uniprot.org/uniprot/Q91XT9", "type": "external" } ], "mass": 83488.0, "length": 761, "protein_name": "Neutral ceramidase", "gene_name": "Asah2", "organism": "Rat", "refseq_name": "neutral ceramidase", "refseq_ac": [ { "id": "NP_446098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446098", "type": "external" } ], "gene_names_uniprotkb": "Asah2", "gene_names_refseq": "Asah2", "protein_names_uniprotkb": "Neutral ceramidase; 3.5.1.-; 3.5.1.23; Acylsphingosine deacylase 2; N-CDase; N-acylsphingosine amidohydrolase 2; NCDase", "protein_names_refseq": "N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; NCDase; acylsphingosine deacylase 2; neutral ceramidase; neutral/alkaline ceramidase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (rno:114104); (R-RNO-9840310)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1039/D0MO00044B;10488143;10781606;11278489;11328816;11330410;11457826;12359735;12482609;12499379;15123644;15217782;21613224;34106099;34610358", "class_list": "", "function": "Low-grade elevation of palmitate and lipopolysaccharide synergistically induced beta-cell damage via inhibition of neutral ceramidase., [RefSeq, PubMed]; Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA., [RefSeq, PubMed]; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10488143, PubMed:11328816, PubMed:15217782). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:11328816). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:15123644). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:15217782). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 3, "predicted_o_glycosites": 13, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0005509 calcium ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006915 apoptotic process;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q91XT9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZC7-1", "uniprot_id": [ { "id": "B2RZC7_RAT", "url": "https://www.uniprot.org/uniprot/B2RZC7", "type": "external" } ], "mass": 44743.0, "length": 392, "protein_name": "Speckle type BTB/POZ protein like", "gene_name": "Spopl", "organism": "Rat", "refseq_name": "speckle-type POZ protein-like isoform b", "refseq_ac": [ { "id": "NP_001127919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127919", "type": "external" } ], "gene_names_uniprotkb": "Spopl", "gene_names_refseq": "RGD1305847; Spopl", "protein_names_uniprotkb": "Speckle type BTB/POZ protein like", "protein_names_refseq": "speckle-type POZ protein-like A; speckle-type POZ protein-like isoform b", "tax_id": 10116, "disease": "", "pathway": " (rno:296532); (R-RNO-5632684)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031397 negative regulation of protein ubiquitination;GO:0030162 regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RZC7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G445-1", "uniprot_id": [ { "id": "A0A8I6G445_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G445", "type": "external" } ], "mass": 113960.0, "length": 1069, "protein_name": "Ataxin 7", "gene_name": "Atxn7", "organism": "Rat", "refseq_name": "ataxin-7 isoform X1", "refseq_ac": [ { "id": "XP_017455330", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017455330", "type": "external" } ], "gene_names_uniprotkb": "Atxn7", "gene_names_refseq": "Atxn7; RGD1562692", "protein_names_uniprotkb": "Ataxin 7", "protein_names_refseq": "ataxin-7 isoform X1", "tax_id": 10116, "disease": "spinocerebellar ataxia 7 (Disease Ontology:DOID:0050958); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:361015); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0042326 negative regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6G445-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ATL0-1", "uniprot_id": [ { "id": "A0A8I6ATL0_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ATL0", "type": "external" } ], "mass": 131620.0, "length": 1206, "protein_name": "Bromodomain-containing protein 8", "gene_name": "Brd8", "organism": "Rat", "refseq_name": "bromodomain-containing protein 8 isoform X1", "refseq_ac": [ { "id": "XP_063133293", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063133293", "type": "external" } ], "gene_names_uniprotkb": "Brd8", "gene_names_refseq": "Brd8; p120", "protein_names_uniprotkb": "Bromodomain-containing protein 8", "protein_names_refseq": "bromodomain-containing protein 8 isoform X1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0005654 nucleoplasm;GO:0000812 Swr1 complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097067 cellular response to thyroid hormone stimulus;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A8I6ATL0-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC57-1", "uniprot_id": [ { "id": "B1WC57_RAT", "url": "https://www.uniprot.org/uniprot/B1WC57", "type": "external" } ], "mass": 25678.0, "length": 228, "protein_name": "Intraflagellar transport protein 25 homolog", "gene_name": "Ift25", "organism": "Rat", "refseq_name": "intraflagellar transport protein 25 homolog isoform X1", "refseq_ac": [ { "id": "XP_006238586", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238586", "type": "external" } ], "gene_names_uniprotkb": "Ift25; Hspb11", "gene_names_refseq": "Hspb11; Ift25", "protein_names_uniprotkb": "Intraflagellar transport protein 25 homolog; Heat shock protein beta-11; Placental protein 25", "protein_names_refseq": "intraflagellar transport protein 25 homolog isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:685284); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A467", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005929 cilium;GO:0030992 intraciliary transport particle B;GO:0005813 centrosome;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0042073 intraciliary transport;GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0001822 kidney development;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE98-1", "uniprot_id": [ { "id": "D3ZE98_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE98", "type": "external" } ], "mass": 25749.0, "length": 225, "protein_name": "Occludin/ELL domain containing 1", "gene_name": "Ocel1", "organism": "Rat", "refseq_name": "occludin/ELL domain-containing protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001423685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423685", "type": "external" } ], "gene_names_uniprotkb": "Ocel1; LOC680815", "gene_names_refseq": "Ocel1; RGD1563236; RGD1565407", "protein_names_uniprotkb": "Occludin/ELL domain containing 1", "protein_names_refseq": "occludin/ELL domain-containing protein 1 isoform 3; occludin/ELL domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290628)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZE98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8P4-1", "uniprot_id": [ { "id": "SACA9_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8P4", "type": "external" } ], "mass": 19465.0, "length": 168, "protein_name": "Sperm acrosome-associated protein 9", "gene_name": "Spaca9", "organism": "Rat", "refseq_name": "sperm acrosome-associated protein 9 isoform 2", "refseq_ac": [ { "id": "NP_859045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859045", "type": "external" } ], "gene_names_uniprotkb": "Spaca9; Rsb66", "gene_names_refseq": "Rsb66; Spaca9", "protein_names_uniprotkb": "Sperm acrosome-associated protein 9", "protein_names_refseq": "Rsb-66 protein; sperm acrosome-associated protein 9 isoform 2; sperm acrosome-associated protein 9; uncharacterized protein C9orf9 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:296610)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18756329", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (By similarity). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (By similarity)., [UniProtKB, UniProtKB]; When being transfected into HeLa cells, RSB-66 and INCA1 were found to be co-localized principally in the cytoplasm. The alpha helix in the RSB-66 C terminal and two amino acid residues (tyr117 and his119) appear to be crucial for its function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSB9", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8P4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04166-1", "uniprot_id": [ { "id": "CYB5B_RAT", "url": "https://www.uniprot.org/uniprot/P04166", "type": "external" } ], "mass": 16265.0, "length": 146, "protein_name": "Cytochrome b5 type B", "gene_name": "Cyb5b", "organism": "Rat", "refseq_name": "cytochrome b5 type B precursor", "refseq_ac": [ { "id": "NP_085075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085075", "type": "external" } ], "gene_names_uniprotkb": "Cyb5b; Cyb5m; Omb5", "gene_names_refseq": "Cyb5b; Cyb5m; omb5", "protein_names_uniprotkb": "Cytochrome b5 type B; Cytochrome b5 outer mitochondrial membrane isoform", "protein_names_refseq": "cytochrome b5 type B (outer mitochondrial membrane); cytochrome b5 type B precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:80773); (R-RNO-1660661); (R-RNO-203615); (R-RNO-211945)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11197480;11583146;16807901;21574570;22203676;6840088;8973214;9484218", "class_list": "", "function": "Comparison of X-ray crystal structures of human and rat CYB5B reveals a striking difference in packing involving the five-strand beta-sheet, which can be attributed to fully buried residue 21 in strand beta4, [RefSeq, PubMed]; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases., [UniProtKB]; Simulations provided qualitative microscopic explanations of many of the differences in physical properties between outer mitochondrial membrane CYB5 isoform and microsomal CYB5 and two mutants in terms of localized changes in structure and flexibility, [RefSeq, PubMed]; The presence of a novel reductive enzyme system of importance for lipid synthesis that is exclusively localized to the outer mitochondrial membrane and is composed of CYB5B, MOSC2, and a third unknown component (a CYB5B reductase)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWG1", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:1903958 nitric-oxide synthase complex;GO:0016020 membrane", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04166-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I5Y792-1", "uniprot_id": [ { "id": "A0A8I5Y792_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I5Y792", "type": "external" } ], "mass": 64296.0, "length": 565, "protein_name": "Phosphodiesterase", "gene_name": "Pde1a", "organism": "Rat", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1", "refseq_ac": [ { "id": "XP_063140682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063140682", "type": "external" } ], "gene_names_uniprotkb": "Pde1a", "gene_names_refseq": "3'-RACEclone8phosphodiesterase1A; 3-RACEclone8phosphodiesterase1A; Pde1a", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:81529); (R-RNO-111957); (R-RNO-418457); (R-RNO-418555)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007165 signal transduction;GO:0048660 regulation of smooth muscle cell proliferation;GO:0034391 regulation of smooth muscle cell apoptotic process;GO:0046069 cGMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I5Y792-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6ATD3-1", "uniprot_id": [ { "id": "A0A8I6ATD3_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6ATD3", "type": "external" } ], "mass": 78783.0, "length": 688, "protein_name": "Band 4.1-like protein 4A", "gene_name": "Epb41l4a", "organism": "Rat", "refseq_name": "band 4.1-like protein 4A isoform 1", "refseq_ac": [ { "id": "NP_001100867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100867", "type": "external" } ], "gene_names_uniprotkb": "Epb41l4a", "gene_names_refseq": "Epb4.1l4a; Epb41l4a", "protein_names_uniprotkb": "Band 4.1-like protein 4A; Erythrocyte membrane protein band 4.1-like 4A; Protein NBL4", "protein_names_refseq": "band 4.1-like protein 4A isoform 1; band 4.1-like protein 4A; erythrocyte protein band 4.1-like 4a", "tax_id": 10116, "disease": "", "pathway": " (rno:307514)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6ATD3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6AV30-1", "uniprot_id": [ { "id": "A0A8I6AV30_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6AV30", "type": "external" } ], "mass": 69695.0, "length": 624, "protein_name": "A-kinase anchoring protein 8 like", "gene_name": "Akap8l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Akap8l", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchoring protein 8 like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:299569); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0042826 histone deacetylase binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016363 nuclear matrix;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0007076 mitotic chromosome condensation;GO:0006397 mRNA processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0044839 cell cycle G2/M phase transition;GO:0010793 regulation of mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6AV30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7ENV6-1", "uniprot_id": [ { "id": "F7ENV6_RAT", "url": "https://www.uniprot.org/uniprot/F7ENV6", "type": "external" } ], "mass": 85796.0, "length": 763, "protein_name": "DNA-binding protein SATB", "gene_name": "Satb1", "organism": "Rat", "refseq_name": "DNA-binding protein SATB1 isoform X5", "refseq_ac": [ { "id": "XP_038939409", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038939409", "type": "external" } ], "gene_names_uniprotkb": "Satb1", "gene_names_refseq": "Satb1", "protein_names_uniprotkb": "DNA-binding protein SATB; Special AT-rich sequence-binding protein", "protein_names_refseq": "DNA-binding protein SATB1 isoform X5", "tax_id": 10116, "disease": "SATB2-associated syndrome (Disease Ontology:DOID:0060428); Sjogren's syndrome (Disease Ontology:DOID:12894)", "pathway": " (R-RNO-111465); (R-RNO-4551638)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0016605 PML body;GO:0000785 chromatin;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0043374 CD8-positive, alpha-beta T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F7ENV6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD47-1", "uniprot_id": [ { "id": "D3ZD47_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD47", "type": "external" } ], "mass": 70056.0, "length": 623, "protein_name": "CBP80/20-dependent translation initiation factor", "gene_name": "Ctif", "organism": "Rat", "refseq_name": "CBP80/20-dependent translation initiation factor isoform X2", "refseq_ac": [ { "id": "XP_038952934", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038952934", "type": "external" } ], "gene_names_uniprotkb": "Ctif", "gene_names_refseq": "Ctif; Gm672", "protein_names_uniprotkb": "CBP80/20-dependent translation initiation factor", "protein_names_refseq": "CBP80/20-dependent translation initiation factor isoform X2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZD47-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8I6G4M9-1", "uniprot_id": [ { "id": "A0A8I6G4M9_RAT", "url": "https://www.uniprot.org/uniprot/A0A8I6G4M9", "type": "external" } ], "mass": 404637.0, "length": 3645, "protein_name": "ALMS1, centrosome and basal body associated protein", "gene_name": "Alms1", "organism": "Rat", "refseq_name": "centrosome-associated protein ALMS1 isoform X2", "refseq_ac": [ { "id": "XP_038963277", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038963277", "type": "external" } ], "gene_names_uniprotkb": "Alms1", "gene_names_refseq": "Alms1", "protein_names_uniprotkb": "ALMS1, centrosome and basal body associated protein", "protein_names_refseq": "centrosome-associated protein ALMS1 isoform X2", "tax_id": 10116, "disease": "Alstrom syndrome (Disease Ontology:DOID:0050473); 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renal agenesis (Disease Ontology:DOID:14766); ovarian cancer (Disease Ontology:DOID:2394); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); schizophrenia (Disease Ontology:DOID:5419); end stage renal disease (Disease Ontology:DOID:783); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (R-RNO-2129379); (R-RNO-216083); (R-RNO-2173789); (R-RNO-3000178)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0008305 integrin complex;GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007399 nervous system development;GO:0007613 memory;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A8I6GID8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A8J8XG97-1", "uniprot_id": [ { "id": "A0A8J8XG97_RAT", "url": "https://www.uniprot.org/uniprot/A0A8J8XG97", "type": "external" } ], "mass": 35760.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or6c1", "organism": "Rat", "refseq_name": "olfactory receptor Olr964", "refseq_ac": [ { "id": "NP_001001073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001073", "type": "external" } ], "gene_names_uniprotkb": "Or6c1", "gene_names_refseq": "Olr964; Or6c1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 6C3-like; olfactory receptor 964; olfactory receptor Olr964; olfactory receptor gene Olr964", "tax_id": 10116, "disease": "", "pathway": " (rno:405963)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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RGD1308009", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 1; adrenal gland protein AD-005", "tax_id": 10116, "disease": "Vissers-Bodmer syndrome (Disease Ontology:DOID:0081397); holoprosencephaly 12 (Disease Ontology:DOID:0081398); heart disease (Disease Ontology:DOID:114)", "pathway": " (rno:291841); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18683930", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0030331 nuclear estrogen receptor binding;GO:0042974 nuclear retinoic acid receptor binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:2000036 regulation of stem cell population maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V7M0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M1H0-1", "uniprot_id": [ { "id": "F1M1H0_RAT", "url": "https://www.uniprot.org/uniprot/F1M1H0", "type": "external" } ], "mass": 35125.0, "length": 318, "protein_name": "Deoxyribose-phosphate aldolase", "gene_name": "Dera", "organism": "Rat", "refseq_name": "deoxyribose-phosphate aldolase", "refseq_ac": [ { "id": "NP_001385935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385935", "type": "external" } ], "gene_names_uniprotkb": "Dera", "gene_names_refseq": "Dera-ps1; 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Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004139 deoxyribose-phosphate aldolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0046386 deoxyribose phosphate catabolic process;GO:0009264 deoxyribonucleotide catabolic process;GO:0016052 carbohydrate catabolic process;GO:0046121 deoxyribonucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M1H0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V810-1", "uniprot_id": [ { "id": "G3V810_RAT", "url": "https://www.uniprot.org/uniprot/G3V810", "type": "external" } ], "mass": 88714.0, "length": 777, "protein_name": "Myotubularin-related protein 10", "gene_name": "Mtmr10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mtmr10", "gene_names_refseq": "", "protein_names_uniprotkb": "Myotubularin-related protein 10; Inactive phosphatidylinositol 3-phosphatase 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:309255)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7L4-1", "uniprot_id": [ { "id": "D4A7L4_RAT", "url": "https://www.uniprot.org/uniprot/D4A7L4", "type": "external" } ], "mass": 17634.0, "length": 151, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "gene_name": "Ndufb11", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "refseq_ac": [ { "id": "NP_001100226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100226", "type": "external" } ], "gene_names_uniprotkb": "Ndufb11", "gene_names_refseq": "Ndufb11; RGD1563698", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; Complex I-ESSS; NADH-ubiquinone oxidoreductase ESSS subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "tax_id": 10116, "disease": "linear skin defects with multiple congenital anomalies 3 (Disease Ontology:DOID:0111876); nuclear type mitochondrial complex I deficiency 30 (Disease Ontology:DOID:0112098)", "pathway": " (rno:299310); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "26446791;29393594", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A7L4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY25-1", "uniprot_id": [ { "id": "D3ZY25_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY25", "type": "external" } ], "mass": 17554.0, "length": 156, "protein_name": "Protein SYS1 homolog", "gene_name": "Dbndd2; Sys1", "organism": "Rat", "refseq_name": "protein SYS1 homolog", "refseq_ac": [ { "id": "NP_001386494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386494", "type": "external" } ], "gene_names_uniprotkb": "Dbndd2; Sys1", "gene_names_refseq": "Sys1", "protein_names_uniprotkb": "Protein SYS1 homolog", "protein_names_refseq": "SYS1 Golgi-localized integral membrane protein homolog; protein SYS1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:685079); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in protein trafficking. May serve as a receptor for ARFRP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0006895 Golgi to endosome transport;GO:0034067 protein localization to Golgi apparatus;GO:0031175 neuron projection development;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZY25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9C9-1", "uniprot_id": [ { "id": "G3V9C9_RAT", "url": "https://www.uniprot.org/uniprot/G3V9C9", "type": "external" } ], "mass": 96454.0, "length": 920, "protein_name": "Zinc finger, MIZ-type containing 2", "gene_name": "Zmiz2", "organism": "Rat", "refseq_name": "zinc finger MIZ domain-containing protein 2", "refseq_ac": [ { "id": "NP_001093977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093977", "type": "external" } ], "gene_names_uniprotkb": "Zmiz2", "gene_names_refseq": "RGD1309256; Zmiz2", "protein_names_uniprotkb": "Zinc finger, MIZ-type containing 2", "protein_names_refseq": "zinc finger MIZ domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:289783)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061665 SUMO ligase activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9C9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ77-1", "uniprot_id": [ { "id": "D3ZJ77_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ77", "type": "external" } ], "mass": 39873.0, "length": 341, "protein_name": "Calcium binding protein 39", "gene_name": "Cab39", "organism": "Rat", "refseq_name": "calcium-binding protein 39 isoform 2", "refseq_ac": [ { "id": "NP_001388554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388554", "type": "external" } ], "gene_names_uniprotkb": "Cab39", "gene_names_refseq": "Cab39; MO25alpha; MO25", "protein_names_uniprotkb": "Calcium binding protein 39", "protein_names_refseq": "calcium-binding protein 39 isoform 2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (rno:301574); (R-RNO-380972); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15292028;18669938;24811174", "class_list": "", "function": "Cab39 differentially interacts with WNK4 and SPAK/OSR1 to switch the classic two kinase cascade into a signal kinase transduction, [RefSeq, PubMed]; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Endurance training markedly increased skeletal muscle LKB1 and MO25 protein without increasing AMPKK activity., [RefSeq, PubMed]; Examine thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0032991 protein-containing complex", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0032147 activation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZJ77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LXU0-1", "uniprot_id": [ { "id": "F1LXU0_RAT", "url": "https://www.uniprot.org/uniprot/F1LXU0", "type": "external" } ], "mass": 238677.0, "length": 2171, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "Med13", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 13", "refseq_ac": [ { "id": "NP_001402014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402014", "type": "external" } ], "gene_names_uniprotkb": "Med13", "gene_names_refseq": "Med13; Thrap1", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 13; thyroid hormone receptor associated protein 1", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 61 (Disease Ontology:DOID:0061034); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:303403); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29746886", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB]; Exercise training can prevent weight gain and pathological cardiac hypertrophy via increased of cardiac MED13 by the regulation of miRNA-208a., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0016592 mediator complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990508 CKM complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LXU0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ56-1", "uniprot_id": [ { "id": "B2RZ56_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ56", "type": "external" } ], "mass": 32233.0, "length": 289, "protein_name": "Mediator of RNA polymerase II transcription subunit 27", "gene_name": "Med27", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Med27", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 27; Cofactor required for Sp1 transcriptional activation subunit 8; Mediator complex subunit 27", "protein_names_refseq": "", 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}, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004672 protein kinase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:1901990 regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3H8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7B4-1", "uniprot_id": [ { "id": "M0R7B4_RAT", "url": "https://www.uniprot.org/uniprot/M0R7B4", "type": "external" } ], "mass": 22234.0, "length": 220, "protein_name": "H1.3 linker histone, cluster member", "gene_name": "H4f3; Hist1h2ai", "organism": "Rat", "refseq_name": "uncharacterized protein LOC684828", "refseq_ac": [ { "id": "NP_001395537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395537", "type": "external" } ], "gene_names_uniprotkb": "H4f3; Hist1h2ai; H2ac10; H2ac13; H2ac23; H4f3; Hist1h1d; Hist1h2ac; Hist1h2af; Hist1h2ail2; Hist1h2an; LOC684773; LOC684828; hist1h2ail2", "gene_names_refseq": "H4f3; Hist1h1d", "protein_names_uniprotkb": "H1.3 linker histone, cluster member", "protein_names_refseq": "histone H1.3; histone cluster 1 H1 family member d; uncharacterized protein LOC684828", "tax_id": 10116, "disease": "", "pathway": " (rno:100360754); (rno:306970); (rno:498753); (rno:684828); (R-RNO-110330); (R-RNO-110331); (R-RNO-140342); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559584); (R-RNO-2559586); (R-RNO-3214815); (R-RNO-3214858); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-5689901); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 38, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. 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"M0R7B4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RC29-1", "uniprot_id": [ { "id": "M0RC29_RAT", "url": "https://www.uniprot.org/uniprot/M0RC29", "type": "external" } ], "mass": 39701.0, "length": 362, "protein_name": "Family with sequence similarity 181, member A", "gene_name": "Fam181a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fam181a", "gene_names_refseq": "", "protein_names_uniprotkb": "Family with sequence similarity 181, member A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:299265)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RC29-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7A9-1", "uniprot_id": [ { "id": "G3V7A9_RAT", "url": "https://www.uniprot.org/uniprot/G3V7A9", "type": "external" } ], "mass": 30374.0, "length": 286, "protein_name": "Claudin 10", "gene_name": "Cldn10", "organism": "Rat", "refseq_name": "claudin-10", "refseq_ac": [ { "id": "NP_001099528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099528", "type": "external" } ], "gene_names_uniprotkb": "Cldn10", "gene_names_refseq": "Cldn10", "protein_names_uniprotkb": "Claudin 10", "protein_names_refseq": "claudin-10", "tax_id": 10116, "disease": "", "pathway": " (rno:290485)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0070160 tight junction", "go_biological_process": "GO:0043269 regulation of monoatomic ion transport;GO:0160184 paracellular transport;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7A9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZT82-1", "uniprot_id": [ { "id": "D3ZT82_RAT", "url": "https://www.uniprot.org/uniprot/D3ZT82", "type": "external" } ], "mass": 40800.0, "length": 360, "protein_name": "Ribosome binding factor A", "gene_name": "Rbfa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rbfa", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome binding factor A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:307235)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, 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"hit_score": 0.1, "record_id": "D3ZT82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZGF3-1", "uniprot_id": [ { "id": "D3ZGF3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZGF3", "type": "external" } ], "mass": 21111.0, "length": 179, "protein_name": "Cilia and flagella associated protein 68", "gene_name": "Cfap68", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 68", "refseq_ac": [ { "id": "NP_001128108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128108", "type": "external" } ], "gene_names_uniprotkb": "Cfap68; C8h11orf1; RGD1564937", "gene_names_refseq": "C8h11orf1; Cfap68; RGD1564937", "protein_names_uniprotkb": "Cilia and flagella associated protein 68", "protein_names_refseq": "UPF0686 protein C11orf1 homolog; cilia- and flagella-associated protein 68", "tax_id": 10116, "disease": "", "pathway": " (rno:500995)", 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"total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZGF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZGK9-1", "uniprot_id": [ { "id": "D3ZGK9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZGK9", "type": "external" } ], "mass": 40521.0, "length": 354, "protein_name": "Nodal growth differentiation factor", "gene_name": "Nodal", "organism": "Rat", "refseq_name": "nodal homolog precursor", "refseq_ac": [ { "id": "NP_001099864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099864", "type": "external" } ], "gene_names_uniprotkb": "Nodal", "gene_names_refseq": "Nodal", "protein_names_uniprotkb": "Nodal growth differentiation factor", "protein_names_refseq": "nodal homolog precursor", "tax_id": 10116, "disease": "anxiety disorder (Disease Ontology:DOID:2030); visceral heterotaxy 5 (Disease Ontology:DOID:758); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (rno:294503)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31298343;31418961;34737126", "class_list": "", "function": "Essential for mesoderm formation and axial patterning during embryonic development., [UniProtKB, UniProtKB]; Nodal mitigates cerebral 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"protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZI74-1", "uniprot_id": [ { "id": "D3ZI74_RAT", "url": "https://www.uniprot.org/uniprot/D3ZI74", "type": "external" } ], "mass": 109633.0, "length": 1039, "protein_name": "Zinc finger protein 628", "gene_name": "Zfp628", "organism": "Rat", "refseq_name": "zinc finger protein 628", "refseq_ac": [ { "id": "NP_001388631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388631", "type": "external" } ], "gene_names_uniprotkb": "Zfp628", "gene_names_refseq": "Zfp628", "protein_names_uniprotkb": "Zinc finger protein 628", "protein_names_refseq": "zinc finger protein 628", "tax_id": 10116, "disease": "", "pathway": " (rno:100359484)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'. Plays a role in spermiogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D4A8F7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZI74-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZI94-1", "uniprot_id": [ { "id": "D3ZI94_RAT", "url": "https://www.uniprot.org/uniprot/D3ZI94", "type": "external" } ], "mass": 25812.0, "length": 235, "protein_name": "Transmembrane protein 215", "gene_name": "Tmem215", "organism": "Rat", "refseq_name": "transmembrane protein 215", "refseq_ac": [ { "id": "NP_001103083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103083", "type": "external" } ], "gene_names_uniprotkb": "Tmem215; LOC690918", "gene_names_refseq": "Tmem215", "protein_names_uniprotkb": "Transmembrane protein 215", "protein_names_refseq": "transmembrane protein 215", "tax_id": 10116, "disease": "", "pathway": " (rno:690918)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001525 angiogenesis;GO:2000352 negative regulation of endothelial cell apoptotic process;GO:0002040 sprouting angiogenesis;GO:0046671 negative regulation of retinal cell programmed cell death;GO:0062099 negative regulation of programmed necrotic cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZI94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIG2-1", "uniprot_id": [ { "id": "D3ZIG2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIG2", "type": "external" } ], "mass": 27986.0, "length": 241, "protein_name": "TP53 target 5", "gene_name": "Tp53tg5", "organism": "Rat", "refseq_name": "TP53-target gene 5 protein", "refseq_ac": [ { "id": "NP_001413916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001413916", "type": "external" } ], "gene_names_uniprotkb": "Tp53tg5; RGD1561934", "gene_names_refseq": "RGD1561934; Tp53tg5", "protein_names_uniprotkb": "TP53 target 5", "protein_names_refseq": "TP53-target gene 5 protein", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZIG2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIQ3-1", "uniprot_id": [ { "id": "D3ZIQ3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIQ3", "type": "external" } ], "mass": 32262.0, "length": 292, "protein_name": "Fat storage-inducing transmembrane protein 1", "gene_name": "Fitm1", "organism": "Rat", "refseq_name": "fat storage-inducing transmembrane protein 1", "refseq_ac": [ { "id": "NP_001099507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099507", "type": "external" } ], "gene_names_uniprotkb": "Fitm1; FIT1; FITM1", "gene_names_refseq": "Fit1; Fitm1; RGD1306911", "protein_names_uniprotkb": "Fat storage-inducing transmembrane protein 1; Fat-inducing protein 1", "protein_names_refseq": "fat storage-inducing transmembrane protein 1; fat-inducing transcript 1", "tax_id": 10116, "disease": "Siddiqi syndrome (Disease Ontology:DOID:0081273); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (rno:290223); (R-RNO-8964572)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0008654 phospholipid biosynthetic process;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZIQ3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIV9-1", "uniprot_id": [ { "id": "D3ZIV9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIV9", "type": "external" } ], "mass": 47412.0, "length": 432, "protein_name": "Cytokine receptor-like factor 1", "gene_name": "Crlf1", "organism": "Rat", "refseq_name": "cytokine receptor-like factor 1 isoform X2", "refseq_ac": [ { "id": "XP_038950259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038950259", "type": "external" } ], "gene_names_uniprotkb": "Crlf1", "gene_names_refseq": "Crlf1", "protein_names_uniprotkb": "Cytokine receptor-like factor 1; Cytokine-like factor 1", "protein_names_refseq": "cytokine receptor-like factor 1 isoform X2", "tax_id": 10116, "disease": "cold-induced sweating syndrome 1 (Disease Ontology:DOID:0080329)", "pathway": " (R-RNO-6788467); (R-RNO-9020956)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity;GO:0005127 ciliary neurotrophic factor receptor binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0097058 CRLF-CLCF1 complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043524 negative regulation of neuron apoptotic process;GO:0009306 protein secretion;GO:0001657 ureteric bud development;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZIV9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIW3-1", "uniprot_id": [ { "id": "D3ZIW3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIW3", "type": "external" } ], "mass": 34466.0, "length": 312, "protein_name": "Olfactory receptor family 10 subfamily D member 3", "gene_name": "Or10d3", "organism": "Rat", "refseq_name": "olfactory receptor Olr1306", "refseq_ac": [ { "id": "NP_001000465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000465", "type": "external" } ], "gene_names_uniprotkb": "Or10d3", "gene_names_refseq": "Olr1306; Or10d3", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily D member 3", "protein_names_refseq": "olfactory receptor 1306; olfactory receptor Olr1306; olfactory receptor gene Olr1306", "tax_id": 10116, "disease": "", "pathway": " (rno:300607)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZIW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ28-1", "uniprot_id": [ { "id": "D3ZJ28_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ28", "type": "external" } ], "mass": 27501.0, "length": 235, "protein_name": "Tripartite motif-containing 52", "gene_name": "Trim52", "organism": "Rat", "refseq_name": "tripartite motif-containing 52", "refseq_ac": [ { "id": "NP_001099526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099526", "type": "external" } ], "gene_names_uniprotkb": "Trim52", "gene_names_refseq": "RGD1565615; Trim52", "protein_names_uniprotkb": "Tripartite motif-containing 52", "protein_names_refseq": "tripartite motif-containing 52", "tax_id": 10116, "disease": "", "pathway": " (rno:290458)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "33122622;38520211", "class_list": "", "function": "TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1beta-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis., [RefSeq, PubMed]; Tripartite Motif Containing 52 Positively Regulates NF-kappaB Signaling by Promoting IkappaBalpha Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, 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"record_id": "D3ZJA7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJR6-1", "uniprot_id": [ { "id": "D3ZJR6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJR6", "type": "external" } ], "mass": 104998.0, "length": 935, "protein_name": "SMCR8-C9orf72 complex subunit", "gene_name": "Smcr8", "organism": "Rat", "refseq_name": "guanine nucleotide exchange protein SMCR8", "refseq_ac": [ { "id": "NP_001178848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178848", "type": "external" } ], "gene_names_uniprotkb": "Smcr8", "gene_names_refseq": "RGD1564621; Smcr8", "protein_names_uniprotkb": "SMCR8-C9orf72 complex subunit", "protein_names_refseq": "Smith-Magenis syndrome chromosome region, candidate 8 homolog; guanine nucleotide exchange protein SMCR8", "tax_id": 10116, "disease": "", "pathway": " (rno:497918)", "pathway_count": 1, "publication_count": 1, 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6AA74", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZL13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZL84-1", "uniprot_id": [ { "id": "D3ZL84_RAT", "url": "https://www.uniprot.org/uniprot/D3ZL84", "type": "external" } ], "mass": 74341.0, "length": 678, "protein_name": "Innate immunity activator", "gene_name": "Inava", "organism": "Rat", "refseq_name": "innate immunity activator protein isoform 1", "refseq_ac": [ { "id": "NP_001421112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421112", "type": "external" } ], "gene_names_uniprotkb": "Inava; RGD1311892", "gene_names_refseq": "Inava; RGD1311892", "protein_names_uniprotkb": "Innate immunity activator", "protein_names_refseq": "innate immunity activator protein isoform 1; uncharacterized protein C1orf106 homolog", "tax_id": 10116, "disease": "inflammatory bowel disease 29 (Disease Ontology:DOID:0112155)", "pathway": " (rno:289399)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0002221 pattern recognition receptor signaling pathway;GO:1903409 reactive oxygen species biosynthetic process;GO:0043410 positive regulation of MAPK cascade;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZL84-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLP0-1", "uniprot_id": [ { "id": "D3ZLP0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLP0", "type": "external" } ], "mass": 56626.0, "length": 515, "protein_name": "Zinc finger and BTB domain-containing protein 8B", "gene_name": "Zbtb8b", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 8B isoform X1", "refseq_ac": [ { "id": "XP_006239029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239029", "type": "external" } ], "gene_names_uniprotkb": "Zbtb8b", "gene_names_refseq": "RGD1562327; Zbtb8b; Zbtb8l; Zbtb8", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 8B", "protein_names_refseq": "zinc finger and BTB domain-containing protein 8B isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLP0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLQ8-1", "uniprot_id": [ { "id": "D3ZLQ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLQ8", "type": "external" } ], "mass": 102130.0, "length": 915, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "Usp20", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 20", "refseq_ac": [ { "id": "NP_001101297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101297", "type": "external" } ], "gene_names_uniprotkb": "Usp20", "gene_names_refseq": "Usp20", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific protease 20", "tax_id": 10116, "disease": "", "pathway": " (rno:311856); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;27156111;29393594", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001664 G protein-coupled receptor binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZLQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLS2-1", "uniprot_id": [ { "id": "D3ZLS2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLS2", "type": "external" } ], "mass": 44768.0, "length": 388, "protein_name": "Sulfotransferase", "gene_name": "Chst4", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 4", "refseq_ac": [ { "id": "NP_001100897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100897", "type": "external" } ], "gene_names_uniprotkb": "Chst4", "gene_names_refseq": "Chst4", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4; carbohydrate (chondroitin 6/keratan) sulfotransferase 4; carbohydrate sulfotransferase 4", "tax_id": 10116, "disease": "macular corneal dystrophy (Disease Ontology:DOID:2565)", "pathway": " (rno:307838); (R-RNO-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006477 protein sulfation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0005975 carbohydrate metabolic process;GO:0050901 leukocyte tethering or rolling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLS2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLV5-1", "uniprot_id": [ { "id": "D3ZLV5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLV5", "type": "external" } ], "mass": 152615.0, "length": 1402, "protein_name": "AT-hook transcription factor", "gene_name": "Akna", "organism": "Rat", "refseq_name": "microtubule organization protein AKNA", "refseq_ac": [ { "id": "NP_001102138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102138", "type": "external" } ], "gene_names_uniprotkb": "Akna", "gene_names_refseq": "Akna", "protein_names_uniprotkb": "AT-hook transcription factor", "protein_names_refseq": "AT-hook-containing transcription factor; microtubule organization protein AKNA", "tax_id": 10116, "disease": "", "pathway": " (rno:362530)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29079362;29393594", "class_list": "", "function": "T-2 toxin activates the PKA/CREB and NF-kappaB/p65 pathways, thereby promoting the direct binding of phospho-CREB and phospho-p65 to the AKNA promoter, thus inhibiting AKNA expression. GH and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) expression were significantly downregulated after AKNA silencing., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0001650 fibrillar center;GO:0005814 centriole", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050727 regulation of inflammatory response;GO:0001837 epithelial to mesenchymal transition;GO:0021849 neuroblast division in subventricular zone;GO:0060232 delamination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZLV5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZM36-1", "uniprot_id": [ { "id": "D3ZM36_RAT", "url": "https://www.uniprot.org/uniprot/D3ZM36", "type": "external" } ], "mass": 41619.0, "length": 362, "protein_name": "Interleukin-10 receptor subunit beta", "gene_name": "Il10rb", "organism": "Rat", "refseq_name": "interleukin-10 receptor subunit beta isoform X2", "refseq_ac": [ { "id": "XP_063126661", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063126661", "type": "external" } ], "gene_names_uniprotkb": "Il10rb", "gene_names_refseq": "Il10rb; RGD1560373", "protein_names_uniprotkb": "Interleukin-10 receptor subunit beta; Coagulation factor III; Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; Interleukin-10 receptor subunit 2; Tissue factor", "protein_names_refseq": "interleukin-10 receptor subunit beta isoform X2", "tax_id": 10116, "disease": "graft-versus-host disease (Disease Ontology:DOID:0081267); inflammatory bowel disease 25 (Disease Ontology:DOID:0110909); hepatitis B (Disease Ontology:DOID:2043); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (R-RNO-6783783); (R-RNO-8854691)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004920 interleukin-10 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:1905571 interleukin-10 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0019221 cytokine-mediated signaling pathway;GO:1901857 positive regulation of cellular respiration;GO:0140105 interleukin-10-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZM36-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZMM8-1", "uniprot_id": [ { "id": "YLAT2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZMM8", "type": "external" } ], "mass": 56815.0, "length": 515, "protein_name": "Y+L amino acid transporter 2", "gene_name": "Slc7a6", "organism": "Rat", "refseq_name": "Y+L amino acid transporter 2", "refseq_ac": [ { "id": "NP_001100894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100894", "type": "external" } ], "gene_names_uniprotkb": "Slc7a6", "gene_names_refseq": "Slc7a6; Y+LAT2; y+LAT-2", "protein_names_uniprotkb": "Y+L amino acid transporter 2; Solute carrier family 7 member 6; Y+LAT2; y(+)L-type amino acid transporter 2; y+LAT-2", "protein_names_refseq": "Y+L amino acid transporter 2; solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; solute carrier family 7 (cationic amino acid transporter, y+ system), member 6; y(+)L-type amino acid transporter 2", "tax_id": 10116, "disease": "", "pathway": " (rno:307811); (R-RNO-210991); (R-RNO-352230)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22401943;22673903;26448619", "class_list": "", "function": "Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:22401943, PubMed:26448619). Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1: 1 (By similarity). Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (PubMed:22401943, PubMed:26448619). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells (By similarity). May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0034618 arginine binding;GO:0015174 basic amino acid transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0106439 L-lysine:L-arginine antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0015820 L-leucine transport;GO:0031460 glycine betaine transport;GO:0015804 neutral amino acid transport;GO:0006809 nitric oxide biosynthetic process;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZMM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZMP7-1", "uniprot_id": [ { "id": "D3ZMP7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZMP7", "type": "external" } ], "mass": 15361.0, "length": 133, "protein_name": "Cystatin domain containing 2", "gene_name": "Cstdc2", "organism": "Rat", "refseq_name": "uncharacterized protein LOC689081 precursor", "refseq_ac": [ { "id": "NP_001102992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102992", "type": "external" } ], "gene_names_uniprotkb": "Cstdc2; LOC689081", "gene_names_refseq": "Cstdc2", "protein_names_uniprotkb": "Cystatin domain containing 2", "protein_names_refseq": "uncharacterized protein LOC689081 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:689081)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019730 antimicrobial humoral response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZMP7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZP23-1", "uniprot_id": [ { "id": "D3ZP23_RAT", "url": "https://www.uniprot.org/uniprot/D3ZP23", "type": "external" } ], "mass": 11479.0, "length": 107, "protein_name": "Dehydrogenase/reductase member 2 like 1", "gene_name": "Dhrs2l1", "organism": "Rat", "refseq_name": "uncharacterized protein LOC290217", "refseq_ac": [ { "id": "NP_001099505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099505", "type": "external" } ], "gene_names_uniprotkb": "Dhrs2l1; RGD1564324", "gene_names_refseq": "Dhrs2l1; RGD1564324", "protein_names_uniprotkb": "Dehydrogenase/reductase member 2 like 1", "protein_names_refseq": "uncharacterized protein LOC290217", "tax_id": 10116, "disease": "", "pathway": " (rno:290217)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZP23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZP29-1", "uniprot_id": [ { "id": "D3ZP29_RAT", "url": "https://www.uniprot.org/uniprot/D3ZP29", "type": "external" } ], "mass": 28727.0, "length": 264, "protein_name": "Intercellular adhesion molecule 4", "gene_name": "Icam4", "organism": "Rat", "refseq_name": "intercellular adhesion molecule 4 precursor", "refseq_ac": [ { "id": "NP_001165548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165548", "type": "external" } ], "gene_names_uniprotkb": "Icam4", "gene_names_refseq": "Icam4", "protein_names_uniprotkb": "Intercellular adhesion molecule 4", "protein_names_refseq": "intercellular adhesion molecule 4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:298702); (R-RNO-198933); (R-RNO-216083)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis. Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion;GO:0006909 phagocytosis;GO:0033631 cell-cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZP29-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPB8-1", "uniprot_id": [ { "id": "D3ZPB8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPB8", "type": "external" } ], "mass": 31555.0, "length": 276, "protein_name": "Transmembrane protein 53", "gene_name": "Tmem53", "organism": "Rat", "refseq_name": "transmembrane protein 53", "refseq_ac": [ { "id": "NP_001101434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101434", "type": "external" } ], "gene_names_uniprotkb": "Tmem53", "gene_names_refseq": "RGD1307066; Tmem53", "protein_names_uniprotkb": "Transmembrane protein 53", "protein_names_refseq": "transmembrane protein 53", "tax_id": 10116, "disease": "craniotubular dysplasia Ikegawa type (Disease Ontology:DOID:0112340)", "pathway": " (rno:313529)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005640 nuclear outer membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0046822 regulation of nucleocytoplasmic transport;GO:0030514 negative regulation of BMP signaling pathway;GO:0045668 negative regulation of osteoblast differentiation;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPB8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPF9-1", "uniprot_id": [ { "id": "D3ZPF9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPF9", "type": "external" } ], "mass": 47531.0, "length": 421, "protein_name": "Serpin B12", "gene_name": "Serpinb12", "organism": "Rat", "refseq_name": "serpin B12", "refseq_ac": [ { "id": "NP_001129339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129339", "type": "external" } ], "gene_names_uniprotkb": "Serpinb12", "gene_names_refseq": "RGD1566382; Serpinb12", "protein_names_uniprotkb": "Serpin B12", "protein_names_refseq": "serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12; serine (or cysteine) peptidase inhibitor, clade B, member 12; serpin B12-like; serpin B12; serpin peptidase inhibitor, clade B (ovalbumin), member 12", "tax_id": 10116, "disease": "", "pathway": " (rno:304692); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. May play a role in cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001533 cornified envelope", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPF9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPV3-1", "uniprot_id": [ { "id": "D3ZPV3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPV3", "type": "external" } ], "mass": 39273.0, "length": 362, "protein_name": "Circadian associated repressor of transcription", "gene_name": "Ciart", "organism": "Rat", "refseq_name": "circadian-associated transcriptional repressor", "refseq_ac": [ { "id": "NP_001128065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128065", "type": "external" } ], "gene_names_uniprotkb": "Ciart; RGD1566380", "gene_names_refseq": "Ciart; RGD1566380", "protein_names_uniprotkb": "Circadian associated repressor of transcription", "protein_names_refseq": "circadian-associated transcriptional repressor; hypothetical gene supported by NM_017187", "tax_id": 10116, "disease": "", "pathway": " (rno:365871)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0045475 locomotor rhythm;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZPV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPX0-1", "uniprot_id": [ { "id": "D3ZPX0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPX0", "type": "external" } ], "mass": 70329.0, "length": 628, "protein_name": "Zinc finger MYM-type containing 5", "gene_name": "Zmym5", "organism": "Rat", "refseq_name": "zinc finger MYM-type containing 5", "refseq_ac": [ { "id": "NP_001419957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419957", "type": "external" } ], "gene_names_uniprotkb": "Zmym5; 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V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZTZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUB3-1", "uniprot_id": [ { "id": "D3ZUB3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUB3", "type": "external" } ], "mass": 39756.0, "length": 359, "protein_name": "Myb/SANT DNA binding domain containing 7", "gene_name": "Msantd7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Msantd7", "gene_names_refseq": "", "protein_names_uniprotkb": "Myb/SANT DNA binding domain containing 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:102547897)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUF1-1", "uniprot_id": [ { "id": "D3ZUF1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUF1", "type": "external" } ], "mass": 19599.0, "length": 172, "protein_name": "Ly6/Plaur domain containing 6B", "gene_name": "Lypd6b", "organism": "Rat", "refseq_name": "ly6/PLAUR domain-containing protein 6B precursor", "refseq_ac": [ { "id": "NP_001382686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382686", "type": "external" } ], "gene_names_uniprotkb": "Lypd6b", "gene_names_refseq": "Lypd6b; RGD1562767", "protein_names_uniprotkb": "Ly6/Plaur domain containing 6B", "protein_names_refseq": "ly6/PLAUR domain-containing protein 6B precursor; ly6/PLAUR domain-containing protein 6B", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-163125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUF1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUJ8-1", "uniprot_id": [ { "id": "D3ZUJ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUJ8", "type": "external" } ], "mass": 104063.0, "length": 920, "protein_name": "Protein O-mannosyl-transferase TMTC3", "gene_name": "Tmtc3", "organism": "Rat", "refseq_name": "protein O-mannosyl-transferase TMTC3", "refseq_ac": [ { "id": "NP_001129330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129330", "type": "external" } ], "gene_names_uniprotkb": "Tmtc3", "gene_names_refseq": "RGD1306351; Tmtc3", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC3; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 3; Transmembrane and tetratricopeptide repeat-containing 3", "protein_names_refseq": "protein O-mannosyl-transferase TMTC3; transmembrane and TPR repeat-containing protein 3; transmembrane and tetratricopeptide repeat containing 3", "tax_id": 10116, "disease": "lissencephaly 8 (Disease Ontology:DOID:0112233); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:314785)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0048286 lung alveolus development;GO:0030324 lung development;GO:0009791 post-embryonic development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZUJ8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUW8-1", "uniprot_id": [ { "id": "D3ZUW8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUW8", "type": "external" } ], "mass": 133492.0, "length": 1189, "protein_name": "Bromodomain containing 1", "gene_name": "Brd1", "organism": "Rat", "refseq_name": "bromodomain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001401875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401875", "type": "external" } ], "gene_names_uniprotkb": "Brd1", "gene_names_refseq": "Brd1", "protein_names_uniprotkb": "Bromodomain containing 1", "protein_names_refseq": "bromodomain-containing protein 1 isoform 1; bromodomain-containing protein 1", "tax_id": 10116, "disease": "bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (R-RNO-3214847); (R-RNO-6804758)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19763615;22341945;22675730", "class_list": "", "function": "Study found a significant 2-fold upregulation of long exon 7 splice variants of the Brd1 gene in hippocampus in both groups of Chronic Restrain Stress rats compared to controls., [RefSeq, PubMed]; These findings indicate that regulation of the Brd1 gene is part of the biological response to ECS and that splice variants are induced differentially in different brain regions., [RefSeq, PubMed]; These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0036408 histone H3K14 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0070776 MOZ/MORF histone acetyltransferase complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045648 positive regulation of erythrocyte differentiation;GO:0051602 response to electrical stimulus;GO:0035902 response to immobilization stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZUW8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUY8-1", "uniprot_id": [ { "id": "D3ZUY8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUY8", "type": "external" } ], "mass": 107666.0, "length": 977, "protein_name": "AP-2 complex subunit alpha", "gene_name": "Ap2a1", "organism": "Rat", "refseq_name": "AP-2 complex subunit alpha-1 isoform 1", "refseq_ac": [ { "id": "NP_001382021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382021", "type": "external" } ], "gene_names_uniprotkb": "Ap2a1", "gene_names_refseq": "Ap2a1", "protein_names_uniprotkb": "AP-2 complex subunit alpha", "protein_names_refseq": "AP-2 complex subunit alpha-1 isoform 1; AP-2 complex subunit alpha-1; adaptor protein complex AP-2, alpha 1 subunit; adaptor-related protein complex 2, alpha 1 subunit; alpha-adaptin A", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (R-RNO-177504); (R-RNO-2132295); (R-RNO-416993); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "16641100;18683930;22673903;26771574;37127089;38843836", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Evidence on differential role for alpha 1 and alpha 2 subtypes of AP-2 adaptin in the central nervous system., [RefSeq, PubMed]; SP-A transiently enhances the basal protein expression of CHC and alpha-adaptin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity;GO:0019901 protein kinase binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0030122 AP-2 adaptor complex;GO:0098978 glutamatergic synapse;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072583 clathrin-dependent endocytosis;GO:0010976 positive regulation of neuron projection development;GO:0048260 positive regulation of receptor-mediated endocytosis;GO:1900126 negative regulation of hyaluronan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "D3ZUY8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVM8-1", "uniprot_id": [ { "id": "D3ZVM8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVM8", "type": "external" } ], "mass": 34851.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or5p60d", "organism": "Rat", "refseq_name": "olfactory receptor Olr257", "refseq_ac": [ { "id": "NP_001001038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001038", "type": "external" } ], "gene_names_uniprotkb": "Or5p60d", "gene_names_refseq": "Olr257; Or5p60d", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 257; olfactory receptor Olr257; olfactory receptor gene Olr257", "tax_id": 10116, "disease": "", "pathway": " (rno:405924)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVM8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVM9-1", "uniprot_id": [ { "id": "D3ZVM9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVM9", "type": "external" } ], "mass": 40213.0, "length": 357, "protein_name": "C-C motif chemokine receptor like 2", "gene_name": "Ccrl2", "organism": "Rat", "refseq_name": "C-C chemokine receptor-like 2 isoform X1", "refseq_ac": [ { "id": "XP_006244028", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244028", "type": "external" } ], "gene_names_uniprotkb": "Ccrl2", "gene_names_refseq": "Ccrl2", "protein_names_uniprotkb": "C-C motif chemokine receptor like 2", "protein_names_refseq": "C-C chemokine receptor-like 2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:316019); 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fascin-2", "tax_id": 10116, "disease": "retinitis pigmentosa 30 (Disease Ontology:DOID:0110406); retinitis pigmentosa (Disease Ontology:DOID:10584); auditory system disease (Disease Ontology:DOID:2742); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:303741)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27989596", "class_list": "", "function": "These data demonstrate that fascin2, a putative target of alpha(E)-catenin, may play important role in preventing cisplatin-induced acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0032420 stereocilium", "go_biological_process": "GO:0016477 cell migration;GO:0051017 actin filament bundle assembly;GO:0007163 establishment or maintenance of cell polarity;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZX02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZX42-1", "uniprot_id": [ { "id": "D3ZX42_RAT", "url": "https://www.uniprot.org/uniprot/D3ZX42", "type": "external" } ], "mass": 120966.0, "length": 1065, "protein_name": "Rab GTPase-activating protein 1", "gene_name": "Rabgap1", "organism": "Rat", "refseq_name": "rab GTPase-activating protein 1", "refseq_ac": [ { "id": "NP_001101311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101311", "type": "external" } ], "gene_names_uniprotkb": "Rabgap1", "gene_names_refseq": "Rabgap1", "protein_names_uniprotkb": "Rab GTPase-activating protein 1; GAP and centrosome-associated protein; Rab6 GTPase-activating protein GAPCenA", "protein_names_refseq": "rab GTPase-activating protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:311911); (R-RNO-8854214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZX42-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXB9-1", "uniprot_id": [ { "id": "D3ZXB9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXB9", "type": "external" } ], "mass": 109741.0, "length": 997, "protein_name": "Sorting nexin-19", "gene_name": "Snx19", "organism": "Rat", "refseq_name": "sorting nexin-19 isoform 1", "refseq_ac": [ { "id": "NP_001101601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101601", "type": "external" } ], "gene_names_uniprotkb": "Snx19", "gene_names_refseq": "Snx19", "protein_names_uniprotkb": "Sorting nexin-19", "protein_names_refseq": "sorting nexin-19 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031901 early endosome membrane", "go_biological_process": "GO:0002062 chondrocyte differentiation;GO:0030073 insulin secretion;GO:1990502 dense core granule maturation;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXB9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXL5-1", "uniprot_id": [ { "id": "D3ZXL5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXL5", "type": "external" } ], "mass": 70086.0, "length": 615, "protein_name": "Nuclear cap-binding protein subunit 3", "gene_name": "Ncbp3", "organism": "Rat", "refseq_name": "nuclear cap-binding protein subunit 3", "refseq_ac": [ { "id": "NP_001101751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101751", "type": "external" } ], "gene_names_uniprotkb": "Ncbp3; RGD1308139", "gene_names_refseq": "Ncbp3; RGD1308139", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 3", "protein_names_refseq": "nuclear cap-binding protein subunit 3; uncharacterized protein C17orf85 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360563)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005846 nuclear cap binding complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0051607 defense response to virus;GO:0006370 7-methylguanosine mRNA capping;GO:0006408 snRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZXL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXN3-1", "uniprot_id": [ { "id": "D3ZXN3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXN3", "type": "external" } ], "mass": 36194.0, "length": 317, "protein_name": "CD209d molecule", "gene_name": "Cd209d", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd209d; Cd209; Clec4m", "gene_names_refseq": "", "protein_names_uniprotkb": "CD209d molecule", "protein_names_refseq": "", "tax_id": 10116, "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); rheumatic heart disease (Disease Ontology:DOID:0050827); Coronavirus infectious disease (Disease Ontology:DOID:0080599); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); aspergillosis (Disease Ontology:DOID:13564); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0038187 pattern recognition receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0001819 positive regulation of cytokine production;GO:0007159 leukocyte cell-cell adhesion;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXN3-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXP8-1", "uniprot_id": [ { "id": "D3ZXP8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXP8", "type": "external" } ], "mass": 13057.0, "length": 120, "protein_name": "Purkinje cell protein 2", "gene_name": "Pcp2", "organism": "Rat", "refseq_name": "Purkinje cell protein 2 homolog", "refseq_ac": [ { "id": "NP_001100586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100586", "type": "external" } ], "gene_names_uniprotkb": "Pcp2", "gene_names_refseq": "Pcp2", "protein_names_uniprotkb": "Purkinje cell protein 2", "protein_names_refseq": "Purkinje cell protein 2 (L7); Purkinje cell protein 2 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:304195); (R-RNO-418594)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function as a cell-type specific modulator for G protein-mediated cell signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0016056 G protein-coupled opsin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZXP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY20-1", "uniprot_id": [ { "id": "D3ZY20_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY20", "type": "external" } ], "mass": 30644.0, "length": 276, "protein_name": "Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2", "gene_name": "Pcmtd2", "organism": "Rat", "refseq_name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X2", "refseq_ac": [ { "id": "XP_038961088", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038961088", "type": "external" } ], "gene_names_uniprotkb": "Pcmtd2", "gene_names_refseq": "Pcmtd2; 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYH6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYM3-1", "uniprot_id": [ { "id": "D3ZYM3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYM3", "type": "external" } ], "mass": 75141.0, "length": 662, "protein_name": "Ecto-NOX disulfide-thiol exchanger 1", "gene_name": "Enox1", "organism": "Rat", "refseq_name": "ecto-NOX disulfide-thiol exchanger 1 isoform X1", "refseq_ac": [ { "id": "XP_038949958", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038949958", "type": "external" } ], "gene_names_uniprotkb": "Enox1", "gene_names_refseq": "Enox1; 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RGD1564228", "protein_names_uniprotkb": "Alpha-N-acetylglucosaminidase; 3.2.1.50", "protein_names_refseq": "N-acetylglucosaminidase, alpha; alpha-N-acetylglucosaminidase", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease axonal type 2V (Disease Ontology:DOID:0110178); mucopolysaccharidosis type IIIB (Disease Ontology:DOID:0111394); otitis media (Disease Ontology:DOID:10754); mucopolysaccharidosis III (Disease Ontology:DOID:12801)", "pathway": " (rno:360630); (R-RNO-2024096)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23360846", "class_list": "", "function": "Urinary KIM-1, NGAL and NAG were compared against serum creatinine and renal histological score in the initiation, maintenance, and recovery phases of cisplatin (CP)-induced acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.50", "type": "external" } ], "go_molecular_function": "GO:0004561 alpha-N-acetylglucosaminidase activity;GO:0140315 iron ion sequestering activity", "go_cellular_component": "GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0043202 lysosomal lumen;GO:0005773 vacuole", "go_biological_process": "GO:0030201 heparan sulfate proteoglycan metabolic process;GO:0048708 astrocyte differentiation;GO:0003170 heart valve development;GO:0001774 microglial cell activation;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZZL3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZR7-1", "uniprot_id": [ { "id": "D3ZZR7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZR7", "type": "external" } ], "mass": 21695.0, "length": 199, "protein_name": "L antigen family member 3", "gene_name": "Ctag2", "organism": "Rat", "refseq_name": "cancer/testis antigen 2", "refseq_ac": [ { "id": "NP_001102792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102792", "type": "external" } ], "gene_names_uniprotkb": "Ctag2", "gene_names_refseq": "Ctag2; RGD1561702", "protein_names_uniprotkb": "L antigen family member 3", "protein_names_refseq": "cancer/testis antigen 2", "tax_id": 10116, "disease": "Galloway-Mowat syndrome 2 (Disease Ontology:DOID:0080244)", "pathway": " (rno:501655)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZR7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A068-1", "uniprot_id": [ { "id": "D4A068_RAT", "url": "https://www.uniprot.org/uniprot/D4A068", "type": "external" } ], "mass": 41248.0, "length": 364, "protein_name": "PNMA family member 2", "gene_name": "Pnma2", "organism": "Rat", "refseq_name": "paraneoplastic antigen Ma2", "refseq_ac": [ { "id": "NP_001100742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100742", "type": "external" } ], "gene_names_uniprotkb": "Pnma2", "gene_names_refseq": "Pnma2", "protein_names_uniprotkb": "PNMA family member 2", "protein_names_refseq": "paraneoplastic Ma antigen 2; paraneoplastic antigen Ma2", "tax_id": 10116, "disease": "", "pathway": " (rno:305977)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A068-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0A9-1", "uniprot_id": [ { "id": "D4A0A9_RAT", "url": "https://www.uniprot.org/uniprot/D4A0A9", "type": "external" } ], "mass": 36053.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or6p1", "organism": "Rat", "refseq_name": "olfactory receptor Olr1601", "refseq_ac": [ { "id": "NP_001000087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000087", "type": "external" } ], "gene_names_uniprotkb": "Or6p1", "gene_names_refseq": "Olr1601; Or6p1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1601; olfactory receptor 6P1; olfactory receptor Olr1601; olfactory receptor gene Olr1601", "tax_id": 10116, "disease": "", "pathway": " (rno:289261)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0A9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0E6-1", "uniprot_id": [ { "id": "D4A0E6_RAT", "url": "https://www.uniprot.org/uniprot/D4A0E6", "type": "external" } ], "mass": 19500.0, "length": 184, "protein_name": "Uroplakin 2", "gene_name": "Upk2", "organism": "Rat", "refseq_name": "uroplakin-2 precursor", "refseq_ac": [ { "id": "NP_001102993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102993", "type": "external" } ], "gene_names_uniprotkb": "Upk2", "gene_names_refseq": "Upk2", "protein_names_uniprotkb": "Uroplakin 2", "protein_names_refseq": "uroplakin-2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:689093)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21301865", "class_list": "", "function": "During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A0E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0I8-1", "uniprot_id": [ { "id": "D4A0I8_RAT", "url": "https://www.uniprot.org/uniprot/D4A0I8", "type": "external" } ], "mass": 100158.0, "length": 930, "protein_name": "Nuclear factor of activated T-cells 2", "gene_name": "Nfatc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nfatc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor of activated T-cells 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:311658); 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"reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0005938 cell cortex", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0007163 establishment or maintenance of cell polarity;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A2F2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2T4-1", "uniprot_id": [ { "id": "D4A2T4_RAT", "url": "https://www.uniprot.org/uniprot/D4A2T4", "type": "external" } ], "mass": 47513.0, "length": 415, "protein_name": "Interferon-gamma-inducible GTPase 4 like", "gene_name": "Ifgga4l", "organism": "Rat", "refseq_name": "interferon-gamma-inducible GTPase Ifgga4 protein", "refseq_ac": [ { "id": "NP_001381913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381913", "type": "external" } ], "gene_names_uniprotkb": "Ifgga4l; RGD1305184", "gene_names_refseq": "Ifgga4l; Ifgga4; RGD1305184", "protein_names_uniprotkb": "Interferon-gamma-inducible GTPase 4 like", "protein_names_refseq": "interferon-gamma-inducible GTPase Ifgga4 protein; interferon-inducible GTPase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:307412)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "J7NUP5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2T4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A304-1", "uniprot_id": [ { "id": "D4A304_RAT", "url": "https://www.uniprot.org/uniprot/D4A304", "type": "external" } ], "mass": 22292.0, "length": 198, "protein_name": "DIRAS family GTPase 1", "gene_name": "Diras1", "organism": "Rat", "refseq_name": "GTP-binding protein Di-Ras1", "refseq_ac": [ { "id": "NP_001102457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102457", "type": "external" } ], "gene_names_uniprotkb": "Diras1", "gene_names_refseq": "Diras1", "protein_names_uniprotkb": "DIRAS family GTPase 1", "protein_names_refseq": "DIRAS family, GTP-binding RAS-like 1; GTP-binding protein Di-Ras1", "tax_id": 10116, "disease": "", "pathway": " (rno:366826)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Displays low GTPase activity and exists predominantly in the GTP-bound form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A304-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A307-1", "uniprot_id": [ { "id": "D4A307_RAT", "url": "https://www.uniprot.org/uniprot/D4A307", "type": "external" } ], "mass": 41749.0, "length": 375, "protein_name": "Protein arginine N-methyltransferase 6", "gene_name": "Prmt6", "organism": "Rat", "refseq_name": "protein arginine N-methyltransferase 6", "refseq_ac": [ { "id": "NP_001380787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380787", "type": "external" } ], "gene_names_uniprotkb": "Prmt6", "gene_names_refseq": "Hrmt1l6; Prmt6", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 6; 2.1.1.319; Histone-arginine N-methyltransferase PRMT6", "protein_names_refseq": "HMT1 hnRNP methyltransferase-like 6; protein arginine N-methyltransferase 6", "tax_id": 10116, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:295384); (R-RNO-3214858); (R-RNO-8936459)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A307-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3B5-1", "uniprot_id": [ { "id": "D4A3B5_RAT", "url": "https://www.uniprot.org/uniprot/D4A3B5", "type": "external" } ], "mass": 51028.0, "length": 466, "protein_name": "Monocarboxylate transporter 6", "gene_name": "Slc16a5", "organism": "Rat", "refseq_name": "monocarboxylate transporter 6", "refseq_ac": [ { "id": "NP_001103038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103038", "type": "external" } ], "gene_names_uniprotkb": "Slc16a5", "gene_names_refseq": "Slc16a5", "protein_names_uniprotkb": "Monocarboxylate transporter 6; Monocarboxylate transporter 5; Solute carrier family 16 member 5", "protein_names_refseq": "monocarboxylate transporter 6; solute carrier family 16 (monocarboxylate transporter), member 5; solute carrier family 16 (monocarboxylic acid transporters), member 5; solute carrier family 16, member 5 (monocarboxylic acid transporter 6)", "tax_id": 10116, "disease": "", "pathway": " (rno:690212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3B5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3E2-1", "uniprot_id": [ { "id": "D4A3E2_RAT", "url": "https://www.uniprot.org/uniprot/D4A3E2", "type": "external" } ], "mass": 56951.0, "length": 535, "protein_name": "Probable aminopeptidase NPEPL1", "gene_name": "Npepl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Npepl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable aminopeptidase NPEPL1; Aminopeptidase-like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311671)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3I5-1", "uniprot_id": [ { "id": "D4A3I5_RAT", "url": "https://www.uniprot.org/uniprot/D4A3I5", "type": "external" } ], "mass": 90120.0, "length": 796, "protein_name": "FHF complex subunit HOOK interacting protein 2A", "gene_name": "Fhip2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fhip2a; Fam160b1", "gene_names_refseq": "", "protein_names_uniprotkb": "FHF complex subunit HOOK interacting protein 2A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361774)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3I5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3T5-1", "uniprot_id": [ { "id": "D4A3T5_RAT", "url": "https://www.uniprot.org/uniprot/D4A3T5", "type": "external" } ], "mass": 26687.0, "length": 255, "protein_name": "Complement C1q like 3", "gene_name": "C1ql3", "organism": "Rat", "refseq_name": "complement C1q-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001102873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102873", "type": "external" } ], "gene_names_uniprotkb": "C1ql3", "gene_names_refseq": "Adij; C1ql3", "protein_names_uniprotkb": "Complement C1q like 3", "protein_names_refseq": "adiponectin j; complement C1q-like protein 3 precursor; complement C1q-like protein 3; complement component 1, q subcomponent-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:680404)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32554851", "class_list": "", "function": "CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKbeta/AMPK pathway in rLSECs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0043083 synaptic cleft;GO:0098978 glutamatergic synapse;GO:0005576 extracellular region", "go_biological_process": "GO:0099558 maintenance of synapse structure;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0097107 postsynaptic density assembly;GO:0050807 regulation of synapse organization;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A3T5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3W9-1", "uniprot_id": [ { "id": "D4A3W9_RAT", "url": "https://www.uniprot.org/uniprot/D4A3W9", "type": "external" } ], "mass": 39658.0, "length": 365, "protein_name": "Protein Wnt", "gene_name": "Wnt6", "organism": "Rat", "refseq_name": "protein Wnt-6 precursor", "refseq_ac": [ { "id": "NP_001101696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101696", "type": "external" } ], "gene_names_uniprotkb": "Wnt6", "gene_names_refseq": "Wnt6", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-6 precursor; protein Wnt-6; wingless-related MMTV integration site 6; wingless-type MMTV integration site family, member 6", "tax_id": 10116, "disease": "", "pathway": " (rno:316526); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0009798 axis specification;GO:0010628 positive regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3W9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3X8-1", "uniprot_id": [ { "id": "D4A3X8_RAT", "url": "https://www.uniprot.org/uniprot/D4A3X8", "type": "external" } ], "mass": 53366.0, "length": 472, "protein_name": "Interleukin-7 receptor subunit alpha", "gene_name": "Il7r", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il7r", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-7 receptor subunit alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); severe combined immunodeficiency (Disease Ontology:DOID:627); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (rno:294797); (R-RNO-1266695); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004917 interleukin-7 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0019725 cellular homeostasis;GO:0050830 defense response to Gram-positive bacterium;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3X8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A409-1", "uniprot_id": [ { "id": "D4A409_RAT", "url": "https://www.uniprot.org/uniprot/D4A409", "type": "external" } ], "mass": 338195.0, "length": 3083, "protein_name": "Basement membrane-specific heparan sulfate proteoglycan core protein", "gene_name": "Lama1", "organism": "Rat", "refseq_name": "laminin subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_001101707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101707", "type": "external" } ], "gene_names_uniprotkb": "Lama1", "gene_names_refseq": "Lama1", "protein_names_uniprotkb": "Basement membrane-specific heparan sulfate proteoglycan core protein; Laminin A chain; Laminin M chain; Laminin subunit alpha-2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain; Perlecan", "protein_names_refseq": "laminin subunit alpha-1 precursor; laminin, alpha 1; laminin-1", "tax_id": 10116, "disease": "muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:316758)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21519634;30153280", "class_list": "", "function": "Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6., [UniProtKB, UniProtKB]; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB, UniProtKB]; Data confirmed aquaporin-4 and laminin-alpha1 induction in cMVs., [RefSeq, PubMed]; Has anti-angiogenic properties that require binding of calcium ions for full activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0046872 metal ion binding;GO:0048018 receptor ligand activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0005911 cell-cell junction;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007166 cell surface receptor signaling pathway;GO:0030155 regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A409-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A488-1", "uniprot_id": [ { "id": "D4A488_RAT", "url": "https://www.uniprot.org/uniprot/D4A488", "type": "external" } ], "mass": 29557.0, "length": 271, "protein_name": "Elastase, neutrophil expressed", "gene_name": "Elane", "organism": "Rat", "refseq_name": "neutrophil elastase precursor", "refseq_ac": [ { "id": "NP_001100237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100237", "type": "external" } ], "gene_names_uniprotkb": "Elane", "gene_names_refseq": "Ela2; Elane", "protein_names_uniprotkb": "Elastase, neutrophil expressed", "protein_names_refseq": "elastase 2, neutrophil; neutrophil elastase precursor; neutrophil elastase", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); mucositis (Disease Ontology:DOID:0080178); COVID-19 (Disease Ontology:DOID:0080600); severe congenital neutropenia 1 (Disease Ontology:DOID:0080625); pleurisy (Disease Ontology:DOID:10247); disseminated intravascular coagulation (Disease Ontology:DOID:11247); toxic shock syndrome (Disease Ontology:DOID:14115); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); suppurative periapical periodontitis (Disease Ontology:DOID:2562); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); cyclic hematopoiesis (Disease Ontology:DOID:5339); periodontitis (Disease Ontology:DOID:824); polycythemia vera (Disease Ontology:DOID:8997); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:299606); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-5620971); (R-RNO-6798695); (R-RNO-6803157); (R-RNO-977606)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "25915831;27430552;31640144;37393835", "class_list": "", "function": "Data show that sivelestat decreases neutrophil elastase (NE) expression in sepsis., [RefSeq, PubMed]; Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats. Erratum:[Int Immunopharmacol. 2024 Feb 15;128:111577. PMID: 38281885], [RefSeq, PubMed]; SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase, [RefSeq, PubMed]; Study provides evidence that an increase in the activity of elastase to cleave PGRN, and to produce GRN, was involved in an inflammatory response at the early stages after cerebral ischemia. 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The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A816-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8A3-1", "uniprot_id": [ { "id": "D4A8A3_RAT", "url": "https://www.uniprot.org/uniprot/D4A8A3", "type": "external" } ], "mass": 35831.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or51b6b", "organism": "Rat", "refseq_name": "olfactory receptor Olr119", "refseq_ac": [ { "id": "NP_001000153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000153", "type": "external" } ], "gene_names_uniprotkb": "Or51b6b", "gene_names_refseq": "Olr119; Or51b6b; ratchr1-161513590-161512637_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 119; olfactory receptor Olr119; olfactory receptor gene Olr119", "tax_id": 10116, "disease": "", "pathway": " (rno:293255)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8A3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8G6-1", "uniprot_id": [ { "id": "D4A8G6_RAT", "url": "https://www.uniprot.org/uniprot/D4A8G6", "type": "external" } ], "mass": 61246.0, "length": 563, "protein_name": "DDB1- and CUL4-associated factor 10", "gene_name": "Dcaf10", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 10", "refseq_ac": [ { "id": "NP_001101405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101405", "type": "external" } ], "gene_names_uniprotkb": "Dcaf10", "gene_names_refseq": "Dcaf10; 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Fdx1l", "gene_names_refseq": "Fdx1l; Fdx2; RGD1561264", "protein_names_uniprotkb": "Ferredoxin-2, mitochondrial; Adrenodoxin-like protein; Ferredoxin-1-like protein", "protein_names_refseq": "adrenodoxin-like protein, mitochondrial; ferredoxin 1-like; ferredoxin-2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:313786); (R-RNO-1362409); (R-RNO-196108); (R-RNO-211976); (R-RNO-2395516)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1904322 cellular response to forskolin;GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain;GO:0044571 [2Fe-2S] cluster assembly;GO:0140647 P450-containing electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A8N2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A8S5-1", "uniprot_id": [ { "id": "D4A8S5_RAT", "url": "https://www.uniprot.org/uniprot/D4A8S5", "type": "external" } ], "mass": 62401.0, "length": 565, "protein_name": "Cell division cycle 7-related protein kinase", "gene_name": "Cdc7", "organism": "Rat", "refseq_name": "cell division cycle 7-related protein kinase", "refseq_ac": [ { "id": "NP_001101822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101822", "type": "external" } ], "gene_names_uniprotkb": "Cdc7", "gene_names_refseq": "Cdc7", "protein_names_uniprotkb": "Cell division cycle 7-related protein kinase; 2.7.11.1", "protein_names_refseq": "cell division cycle 7 homolog; cell division cycle 7-related protein kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:360908); (R-RNO-176187); (R-RNO-68962)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "31819079", "class_list": "", "function": "Cdc7 kinase stimulates Aurora B kinase in M-phase. Publication Status: Online-Only, [RefSeq, PubMed]; Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, 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Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. 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Required to target TOM1 to endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 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RGD1565521; RGD1565561", "protein_names_uniprotkb": "Membrane bound O-acyltransferase domain containing 1", "protein_names_refseq": "lysophospholipid acyltransferase 1; membrane bound O-acyltransferase domain containing 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498741); (R-RNO-1482801); (R-RNO-1482839)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0010975 regulation of neuron projection development;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LV18-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LVF9-1", "uniprot_id": [ { "id": "F1LVF9_RAT", "url": "https://www.uniprot.org/uniprot/F1LVF9", "type": "external" } ], "mass": 27237.0, "length": 246, "protein_name": "Ubiquitin domain containing 2", "gene_name": "Ubtd2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubtd2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin domain containing 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LVF9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LXP8-1", "uniprot_id": [ { "id": "F1LXP8_RAT", "url": "https://www.uniprot.org/uniprot/F1LXP8", "type": "external" } ], "mass": 74941.0, "length": 665, "protein_name": "Rho GTPase-activating protein 18", "gene_name": "Arhgap18", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 18", "refseq_ac": [ { "id": "NP_001164046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164046", "type": "external" } ], "gene_names_uniprotkb": "Arhgap18", "gene_names_refseq": "Arhgap18", "protein_names_uniprotkb": "Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18", "protein_names_refseq": "rho GTPase-activating protein 18", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:293947); (R-RNO-8980692); (R-RNO-9013106)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001726 ruffle;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0051056 regulation of small GTPase mediated signal transduction;GO:2000145 regulation of cell motility;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LXP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LYE0-1", "uniprot_id": [ { "id": "F1LYE0_RAT", "url": "https://www.uniprot.org/uniprot/F1LYE0", "type": "external" } ], "mass": 23276.0, "length": 205, "protein_name": "Ectodysplasin-A receptor-associated adapter protein", "gene_name": "Edaradd", "organism": "Rat", "refseq_name": "ectodysplasin-A receptor-associated adapter protein", "refseq_ac": [ { "id": "NP_001419240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419240", "type": "external" } ], "gene_names_uniprotkb": "Edaradd", "gene_names_refseq": "Edaradd; RGD1564010", "protein_names_uniprotkb": "Ectodysplasin-A receptor-associated adapter protein", "protein_names_refseq": "EDAR (ectodysplasin-A receptor)-associated death domain; EDAR-associated death domain; ectodysplasin-A receptor-associated adapter protein", "tax_id": 10116, "disease": "ectodermal dysplasia 11A (Disease Ontology:DOID:0111653); ectodermal dysplasia 11B (Disease Ontology:DOID:0111654); otitis media (Disease Ontology:DOID:10754); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793)", "pathway": " (rno:498769); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22013926;29393594", "class_list": "", "function": "Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings suggest that sparse-and-wavy (swh) is a loss-of-function mutation in the rat Edaradd gene Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0030154 cell differentiation;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0001942 hair follicle development;GO:0042475 odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LYE0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M0C0-1", "uniprot_id": [ { "id": "F1M0C0_RAT", "url": "https://www.uniprot.org/uniprot/F1M0C0", "type": "external" } ], "mass": 75100.0, "length": 711, "protein_name": "T-box transcription factor 2", "gene_name": "Tbx2", "organism": "Rat", "refseq_name": "T-box transcription factor TBX2", "refseq_ac": [ { "id": "NP_001388735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388735", "type": "external" } ], "gene_names_uniprotkb": "Tbx2", "gene_names_refseq": "Tbx2", "protein_names_uniprotkb": "T-box transcription factor 2", "protein_names_refseq": "T-box 2; T-box transcription factor TBX2", "tax_id": 10116, "disease": "vertebral anomalies and variable endocrine and T-cell dysfunction (Disease Ontology:DOID:0070345); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); heart septal defect (Disease Ontology:DOID:1681); atrial heart septal defect (Disease Ontology:DOID:1882)", "pathway": " (rno:303398)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12733958", "class_list": "", "function": "Tbx2 is a negative regulator of connexin 43 expression at the transcriptional level in cranial sutures [Tbx2][cx43], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0036302 atrioventricular canal development;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0097325 melanocyte proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M0C0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M1Y4-1", "uniprot_id": [ { "id": "F1M1Y4_RAT", "url": "https://www.uniprot.org/uniprot/F1M1Y4", "type": "external" } ], "mass": 65215.0, "length": 578, "protein_name": "PHD finger protein 19", "gene_name": "Phf19", "organism": "Rat", "refseq_name": "PHD finger protein 19", "refseq_ac": [ { "id": "NP_001100040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100040", "type": "external" } ], "gene_names_uniprotkb": "Phf19", "gene_names_refseq": "Phf19", "protein_names_uniprotkb": "PHD finger protein 19; Polycomb-like protein 3", "protein_names_refseq": "PHD finger protein 19", "tax_id": 10116, "disease": "", "pathway": " (rno:296653); (R-RNO-212300)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "33611744", "class_list": "", "function": "PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically Regulating SIRT2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0048863 stem cell differentiation;GO:0019827 stem cell population maintenance;GO:0045814 negative regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M1Y4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M2T9-1", "uniprot_id": [ { "id": "F1M2T9_RAT", "url": "https://www.uniprot.org/uniprot/F1M2T9", "type": "external" } ], "mass": 35009.0, "length": 314, "protein_name": "Olfactory receptor family 10 subfamily D member 4B", "gene_name": "Or10d4b; Or10d4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or10d4b; Or10d4; Or10d4", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor family 10 subfamily D member 4B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300613); (rno:405078)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M2T9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M443-1", "uniprot_id": [ { "id": "F1M443_RAT", "url": "https://www.uniprot.org/uniprot/F1M443", "type": "external" } ], "mass": 474984.0, "length": 4243, "protein_name": "Low-density lipoprotein receptor-related protein 1B", "gene_name": "Lrp1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrp1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 1B; Low-density lipoprotein receptor-related protein-deleted in tumor", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); epilepsy (Disease Ontology:DOID:1826); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gallbladder cancer (Disease Ontology:DOID:3121); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0043235 receptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M443-1", "record_type": "protein", "filter_code": "0000000.0000010.001000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M6E7-1", "uniprot_id": [ { "id": "F1M6E7_RAT", "url": "https://www.uniprot.org/uniprot/F1M6E7", "type": "external" } ], "mass": 18304.0, "length": 163, "protein_name": "Sperm acrosome membrane-associated protein 3", "gene_name": "Spaca3", "organism": "Rat", "refseq_name": "sperm acrosome membrane-associated protein 3 precursor", "refseq_ac": [ { "id": "NP_001099290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099290", "type": "external" } ], "gene_names_uniprotkb": "Spaca3", "gene_names_refseq": "Lyzc; Spaca3", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 3", "protein_names_refseq": "lysozyme c; sperm acrosome membrane-associated protein 3 precursor; sperm acrosome membrane-associated protein 3", "tax_id": 10116, "disease": "viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (rno:287557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030141 secretory granule;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0002080 acrosomal membrane;GO:0043159 acrosomal matrix", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M6E7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M9W9-1", "uniprot_id": [ { "id": "F1M9W9_RAT", "url": "https://www.uniprot.org/uniprot/F1M9W9", "type": "external" } ], "mass": 161178.0, "length": 1440, "protein_name": "Trafficking protein particle complex subunit 8", "gene_name": "Trappc8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trappc8", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8876198)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:1990072 TRAPPIII protein complex;GO:0030008 TRAPP complex", "go_biological_process": "GO:0007030 Golgi organization;GO:0032964 collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M9W9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q5K7-1", "uniprot_id": [ { "id": "F6Q5K7_RAT", "url": "https://www.uniprot.org/uniprot/F6Q5K7", "type": "external" } ], "mass": 29159.0, "length": 257, "protein_name": "Small ribosomal subunit protein mS40", "gene_name": "Mrps18b", "organism": "Rat", "refseq_name": "small ribosomal subunit protein mS40", "refseq_ac": [ { "id": "NP_997699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997699", "type": "external" } ], "gene_names_uniprotkb": "Mrps18b", "gene_names_refseq": "Mrps18b; Ptd017", "protein_names_uniprotkb": "Small ribosomal subunit protein mS40; 28S ribosomal protein S18-2, mitochondrial; 28S ribosomal protein S18b, mitochondrial", "protein_names_refseq": "28S ribosomal protein S18b, mitochondrial; small ribosomal subunit protein mS40", "tax_id": 10116, "disease": "", "pathway": " (rno:294230); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q5K7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FG68-1", "uniprot_id": [ { "id": "F7FG68_RAT", "url": "https://www.uniprot.org/uniprot/F7FG68", "type": "external" } ], "mass": 67257.0, "length": 612, "protein_name": "E3 ubiquitin-protein ligase synoviolin", "gene_name": "Syvn1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase synoviolin isoform 1", "refseq_ac": [ { "id": "NP_001426924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426924", "type": "external" } ], "gene_names_uniprotkb": "Syvn1", "gene_names_refseq": "RGD1310488; Syvn1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase synoviolin; 2.3.2.27; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1", "protein_names_refseq": "E3 ubiquitin-protein ligase synoviolin isoform 1; E3 ubiquitin-protein ligase synoviolin; HRD1 protein; synovial apoptosis inhibitor 1, synoviolin", "tax_id": 10116, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372)", "pathway": " (rno:361712); (R-RNO-5358346)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "28992619;30248386;36193086;37591122", "class_list": "", "function": "Endoplasmic reticulum stress induces HRD1 to protect alveolar type II epithelial cells from apoptosis induced by cigarette smoke extract., [RefSeq, PubMed]; Hrd1 might mediate the ubiquitination of IGF-1R through sema3a and then participate in the regulation of cardiomyocyte apoptosis., [RefSeq, PubMed]; SYVN1 attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury in rats by regulating the HMGB1/NRF2/HO-1 axis., [RefSeq, PubMed]; The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission. 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spliceosome;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V6I3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6I6-1", "uniprot_id": [ { "id": "G3V6I6_RAT", "url": "https://www.uniprot.org/uniprot/G3V6I6", "type": "external" } ], "mass": 42408.0, "length": 375, "protein_name": "Adiponectin receptor 1", "gene_name": "Adipor1", "organism": "Rat", "refseq_name": "adiponectin receptor protein 1", "refseq_ac": [ { "id": "NP_997470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997470", "type": "external" } ], "gene_names_uniprotkb": "Adipor1", "gene_names_refseq": "Adipor1", "protein_names_uniprotkb": "Adiponectin receptor 1", "protein_names_refseq": "adiponectin receptor protein 1", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); hyperinsulinism (Disease Ontology:DOID:2018); prostate adenocarcinoma (Disease Ontology:DOID:2526); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); end stage renal disease (Disease Ontology:DOID:783); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:289036); (R-RNO-163680)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16415076;16483885;32940654;34973346;34973951;35271883;37758935", "class_list": "", "function": "AdipoR1 might play a role in the pathogenesis of endothelin-1-related cardiomyocyte hypertrophy after myocardial infarction, [RefSeq, PubMed]; Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; Crosstalk relationship between adiponectin receptors, PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic WKYs., [RefSeq, PubMed]; GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension., [RefSeq, PubMed]; Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats., [RefSeq, PubMed]; Results do not support an important role for the expression of AdipoR1 and AdipoR2 in the modulation of sensitivity to insulin., [RefSeq, PubMed]; The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0055100 adiponectin binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0010906 regulation of glucose metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0019395 fatty acid oxidation;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "G3V6I6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6K4-1", "uniprot_id": [ { "id": "G3V6K4_RAT", "url": "https://www.uniprot.org/uniprot/G3V6K4", "type": "external" } ], "mass": 103892.0, "length": 945, "protein_name": "DDB1- and CUL4-associated factor 5", "gene_name": "Dcaf5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dcaf5", "gene_names_refseq": "", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 5; WD repeat-containing protein 22", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:314273); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V6K4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V6K9-1", "uniprot_id": [ { "id": "G3V6K9_RAT", "url": "https://www.uniprot.org/uniprot/G3V6K9", "type": "external" } ], "mass": 119141.0, "length": 1040, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "Rag1", "organism": "Rat", "refseq_name": "V(D)J recombination-activating protein 1", "refseq_ac": [ { "id": "NP_445920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445920", "type": "external" } ], "gene_names_uniprotkb": "Rag1", "gene_names_refseq": "Rag1", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; 2.3.2.27; 3.1.-.-", "protein_names_refseq": "V(D)J recombination-activating protein 1; recombination activating gene 1; recombination activation protein 1; recombination-activating protein 1", "tax_id": 10116, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (Disease Ontology:DOID:0090013); combined cellular and humoral immune defects with granulomas (Disease Ontology:DOID:0112253); hypertension (Disease Ontology:DOID:10763); severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (rno:84600)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23364523;29537860", "class_list": "", "function": "Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends., [UniProtKB, UniProtKB]; Rag1-null Dahl SS rats provide evidence that adaptive immune mechanisms contribute to the exacerbation of salt-induced hypertension and renal injury mediated by increased dietary protein intake., [RefSeq, PubMed]; The infiltration of T cells into the kidney following high-salt intake was significantly blunted in the Rag1-null rats, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7A2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7A7-1", "uniprot_id": [ { "id": "G3V7A7_RAT", "url": "https://www.uniprot.org/uniprot/G3V7A7", "type": "external" } ], "mass": 41239.0, "length": 365, "protein_name": "Similar to human chromosome 2 open reading frame 69", "gene_name": "C9h2orf69", "organism": "Rat", "refseq_name": "mitochondrial protein C2orf69 homolog precursor", "refseq_ac": [ { "id": "NP_001101689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101689", "type": "external" } ], "gene_names_uniprotkb": "C9h2orf69; RGD1306941", "gene_names_refseq": "C9h2orf69; RGD1306941", "protein_names_uniprotkb": "Similar to human chromosome 2 open reading frame 69", "protein_names_refseq": "UPF0565 protein C2orf69 homolog; mitochondrial protein C2orf69 homolog precursor; mitochondrial protein C2orf69 homolog", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 53 (Disease Ontology:DOID:0070426)", "pathway": " (rno:316406)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7A7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7D4-1", "uniprot_id": [ { "id": "G3V7D4_RAT", "url": "https://www.uniprot.org/uniprot/G3V7D4", "type": "external" } ], "mass": 35793.0, "length": 340, "protein_name": "Ephrin-B3", "gene_name": "Efnb3", "organism": "Rat", "refseq_name": "ephrin-B3 precursor", "refseq_ac": [ { "id": "NP_001094450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094450", "type": "external" } ], "gene_names_uniprotkb": "Efnb3; Wrap53", "gene_names_refseq": "ELK-L3; Efnb3", "protein_names_uniprotkb": "Ephrin-B3", "protein_names_refseq": "ephrin ligand B3; ephrin-B3 precursor", "tax_id": 10116, "disease": "movement disease (Disease Ontology:DOID:480)", "pathway": " (rno:360546); (R-RNO-2682334); (R-RNO-3928662); (R-RNO-3928664); (R-RNO-3928665)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "12383247;24604122;26479588;26687980;26930615;37924857;38843836", "class_list": "", "function": "Axonal growth was inhibited in cells from the lateral thalamus exposed to ephrin B3 but not from the medial thalamus, suggesting that ephrin-B3 contributes to regional specificity by suppressing axonal growth of lateral thalamic neurons., [RefSeq, PubMed]; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ephrin-B3 specifies the synaptic localization of PSD-95 and likely links the synaptic stability of PSD-95 to changes in neuronal activity, [RefSeq, PubMed]; EphrinB3 silencing contributes to axonal growth regeneration and improves recovery from spinal cord injury (SCI)., [RefSeq, PubMed]; Findings suggest that EphrinB3 may be a relevant target for promoting remyelination in demyelinating disease Erratum:[Acta Neuropathol. 2016 Jul;132(1):157. PMID: 27161252], [RefSeq, PubMed]; In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals., [RefSeq, PubMed]; Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0016020 membrane;GO:0005829 cytosol", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance;GO:0016198 axon choice point recognition;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "G3V7D4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7F8-1", "uniprot_id": [ { "id": "G3V7F8_RAT", "url": "https://www.uniprot.org/uniprot/G3V7F8", "type": "external" } ], "mass": 9675.0, "length": 81, "protein_name": "Uncharacterized protein", "gene_name": "AABR07012054.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07012054.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7F8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7G9-1", "uniprot_id": [ { "id": "G3V7G9_RAT", "url": "https://www.uniprot.org/uniprot/G3V7G9", "type": "external" } ], "mass": 66711.0, "length": 564, "protein_name": "Eukaryotic translation initiation factor 3 subunit L", "gene_name": "Eif3l", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit L", "refseq_ac": [ { "id": "NP_001029306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029306", "type": "external" } ], "gene_names_uniprotkb": "Eif3l; EIF3EIP; EIF3L; EIF3S6IP; Eif3s6ip", "gene_names_refseq": "Eif3l; Eif3s6ip", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit L; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic translation initiation factor 3 subunit E-interacting protein; eIF3l", "protein_names_refseq": "eukaryotic translation initiation factor 3 subunit L; eukaryotic translation initiation factor 3, subunit 6 interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300069); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q498D2", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0016282 eukaryotic 43S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7G9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7K5-1", "uniprot_id": [ { "id": "G3V7K5_RAT", "url": "https://www.uniprot.org/uniprot/G3V7K5", "type": "external" } ], "mass": 142951.0, "length": 1278, "protein_name": "NPC intracellular cholesterol transporter 1", "gene_name": "Npc1", "organism": "Rat", "refseq_name": "NPC intracellular cholesterol transporter 1 precursor", "refseq_ac": [ { "id": "NP_705888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705888", "type": "external" } ], "gene_names_uniprotkb": "Npc1", "gene_names_refseq": "Cdig2; Npc1; SLC66A1", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 1", "protein_names_refseq": "NPC intracellular cholesterol transporter 1 precursor; Niemann-Pick disease, type C1; solute carrier family 66 member 1", "tax_id": 10116, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (rno:266732); (R-RNO-8964038)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27466344;34183444;38843836", "class_list": "", "function": "Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC disease and uncovers new targets for therapeutic approaches., [RefSeq, PubMed]; Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity;GO:0005319 lipid transporter activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031579 membrane raft organization;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0001889 liver development;GO:0006897 endocytosis;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V7K5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7N0-1", "uniprot_id": [ { "id": "G3V7N0_RAT", "url": "https://www.uniprot.org/uniprot/G3V7N0", "type": "external" } ], "mass": 41851.0, "length": 356, "protein_name": "Heparan sulfate 2-O-sulfotransferase 1", "gene_name": "Hs2st1", "organism": "Rat", "refseq_name": "heparan sulfate 2-O-sulfotransferase 1", "refseq_ac": [ { "id": "NP_001093988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093988", "type": "external" } ], "gene_names_uniprotkb": "Hs2st1", "gene_names_refseq": "Hs2st1", "protein_names_uniprotkb": "Heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; HS 2-O-sulfotransferase; Heparan sulfate 2-sulfotransferase", "protein_names_refseq": "heparan sulfate 2-O-sulfotransferase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292155); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "33161775;38843836", "class_list": "", "function": "Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme., [UniProtKB, UniProtKB]; Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004394 heparan sulfate 2-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0010467 gene expression;GO:0030202 heparin proteoglycan metabolic process;GO:0060676 ureteric bud formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "G3V7N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7N6-1", "uniprot_id": [ { "id": "G3V7N6_RAT", "url": "https://www.uniprot.org/uniprot/G3V7N6", "type": "external" } ], "mass": 53380.0, "length": 473, "protein_name": "Leukocyte receptor cluster member 4", "gene_name": "Mboat7", "organism": "Rat", "refseq_name": "lysophospholipid acyltransferase 7", "refseq_ac": [ { "id": "NP_001128450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128450", "type": "external" } ], "gene_names_uniprotkb": "Mboat7", "gene_names_refseq": "Leng4; Mboat7l1; Mboat7; RGD1306945", "protein_names_uniprotkb": "Leukocyte receptor cluster member 4; Lysophospholipid acyltransferase 7; Membrane-bound O-acyltransferase domain-containing protein 7", "protein_names_refseq": "leukocyte receptor cluster (LRC) member 4; lysophospholipid acyltransferase 7; membrane bound O-acyltransferase domain containing 7-like 1; membrane bound O-acyltransferase domain containing 7", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 57 (Disease Ontology:DOID:0081219); hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:308309); (R-RNO-1482922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, 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"go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006661 phosphatidylinositol biosynthetic process;GO:0021819 layer formation in cerebral cortex;GO:0021591 ventricular system development;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7N6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7T2-1", "uniprot_id": [ { "id": "G3V7T2_RAT", "url": "https://www.uniprot.org/uniprot/G3V7T2", "type": "external" } ], "mass": 40428.0, "length": 356, "protein_name": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "gene_name": "St8sia1", "organism": "Rat", "refseq_name": "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase", "refseq_ac": [ { "id": "NP_036945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036945", "type": "external" } ], "gene_names_uniprotkb": "St8sia1", "gene_names_refseq": "Siat8a; Siat8; St8sia1", "protein_names_uniprotkb": "Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; 2.4.3.8; Alpha-2,8-sialyltransferase 8A; Ganglioside GD3 synthase; Ganglioside GT3 synthase; Sialyltransferase 8A; Sialyltransferase St8Sia I", "protein_names_refseq": "ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1; Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase); Sialyltransferase 8 A (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) GenBank no: U53883; alpha-2, 8-sialytransferase; alpha-2,8-sialyltransferase; alpha-N-acetylneuraminate: alpha-2,8-sialytransferase; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; sialyltransferase 8 (alpha-2 8-sialytransferase) A", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (rno:25280); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15645117", "class_list": "", "function": "Alpha2,8-sialyltransferase has roles in cell proliferation and mobility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.8", "type": "external" }, { "id": "2.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.-", "type": "external" }, { "id": "2.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006665 sphingolipid metabolic process;GO:0034605 cellular response to heat;GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing", "synthesized_glycan_count": 21, "hit_score": 0.2, "record_id": "G3V7T2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7W9-1", "uniprot_id": [ { "id": "G3V7W9_RAT", "url": "https://www.uniprot.org/uniprot/G3V7W9", "type": "external" } ], "mass": 14586.0, "length": 134, "protein_name": "Interferon induced transmembrane protein 5", "gene_name": "Ifitm5", "organism": "Rat", "refseq_name": "interferon-induced transmembrane protein 5", "refseq_ac": [ { "id": "XP_002728878", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002728878", "type": "external" } ], "gene_names_uniprotkb": "Ifitm5", "gene_names_refseq": "Ifitm5", "protein_names_uniprotkb": "Interferon induced transmembrane protein 5", "protein_names_refseq": "interferon-induced transmembrane protein 5", "tax_id": 10116, "disease": "osteogenesis imperfecta type 5 (Disease Ontology:DOID:0110344)", "pathway": " (rno:293617)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, 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"uniprot_canonical_ac": "G3V7Y6-1", "uniprot_id": [ { "id": "G3V7Y6_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Y6", "type": "external" } ], "mass": 44341.0, "length": 401, "protein_name": "Forkhead box protein H1", "gene_name": "Foxh1", "organism": "Rat", "refseq_name": "forkhead box protein H1", "refseq_ac": [ { "id": "NP_001123965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123965", "type": "external" } ], "gene_names_uniprotkb": "Foxh1", "gene_names_refseq": "Foxh1", "protein_names_uniprotkb": "Forkhead box protein H1; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2", "protein_names_refseq": "forkhead box protein H1", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); agnathia-otocephaly complex (Disease Ontology:DOID:0060341)", "pathway": " (rno:300054)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032444 activin responsive factor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7Y6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V816-1", "uniprot_id": [ { "id": "G3V816_RAT", "url": "https://www.uniprot.org/uniprot/G3V816", "type": "external" } ], "mass": 19119.0, "length": 169, "protein_name": "Nucleoside diphosphate kinase", "gene_name": "Nme3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nme3", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoside diphosphate kinase; 2.7.4.6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-499943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis. In vitro, can also use other phosphate donors such as UTP and GTP. Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization. Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity. Inhibits granulocyte differentiation. 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In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex", "go_biological_process": "GO:0070682 proteasome regulatory particle assembly;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8G2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8L1-1", "uniprot_id": [ { "id": "G3V8L1_RAT", "url": "https://www.uniprot.org/uniprot/G3V8L1", "type": "external" } ], "mass": 21673.0, "length": 193, "protein_name": "Apoptosis-associated speck-like protein containing a CARD", "gene_name": "Pycard", "organism": "Rat", "refseq_name": "apoptosis-associated speck-like protein containing a CARD", "refseq_ac": [ { "id": "NP_758825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758825", "type": "external" } ], "gene_names_uniprotkb": "Pycard", "gene_names_refseq": "Asc; 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pcdh-T5", "protein_names_uniprotkb": "Protocadherin beta 22", "protein_names_refseq": "protocadherin beta-15; protocadherin-T5", "tax_id": 10116, "disease": "", "pathway": " (rno:307486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8N1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8N7-1", "uniprot_id": [ { "id": "G3V8N7_RAT", "url": "https://www.uniprot.org/uniprot/G3V8N7", "type": "external" } ], "mass": 85279.0, "length": 779, "protein_name": "Protocadherin beta 4", "gene_name": "Pcdhb8", "organism": "Rat", "refseq_name": "protocadherin beta 4", "refseq_ac": [ { "id": "NP_001108073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108073", "type": "external" } ], "gene_names_uniprotkb": "Pcdhb8; Pcdhb4", "gene_names_refseq": "Pcdhb4", "protein_names_uniprotkb": "Protocadherin beta 4", "protein_names_refseq": "protocadherin beta 4", "tax_id": 10116, "disease": "", "pathway": " (rno:291655); (rno:680020)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8N7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8U0-1", "uniprot_id": [ { "id": "G3V8U0_RAT", "url": "https://www.uniprot.org/uniprot/G3V8U0", "type": "external" } ], "mass": 76450.0, "length": 698, "protein_name": "T-cell differentiation antigen CD6", "gene_name": "Cd6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd6", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell differentiation antigen CD6", "protein_names_refseq": "", "tax_id": 10116, "disease": "carboxypeptidase N deficiency (Disease Ontology:DOID:0111583)", "pathway": " (rno:25752)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0042101 T cell receptor complex;GO:0001772 immunological synapse", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0042102 positive regulation of T cell proliferation;GO:0031663 lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8U0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Y2-1", "uniprot_id": [ { "id": "G3V8Y2_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Y2", "type": "external" } ], "mass": 122592.0, "length": 1116, "protein_name": "Leucine-rich repeats and immunoglobulin-like domains 3", "gene_name": "Lrig3", "organism": "Rat", "refseq_name": "leucine-rich repeats and immunoglobulin-like domains protein 3 precursor", "refseq_ac": [ { "id": "NP_001419387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419387", "type": "external" } ], "gene_names_uniprotkb": "Lrig3", "gene_names_refseq": "Lrig3; RGD1561255", "protein_names_uniprotkb": "Leucine-rich repeats and immunoglobulin-like domains 3", "protein_names_refseq": "leucine-rich repeats and immunoglobulin-like domains protein 3 precursor; leucine-rich repeats and immunoglobulin-like domains protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:299830)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31119777", "class_list": "", "function": "Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DEJ0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032474 otolith morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8Y2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Y5-1", "uniprot_id": [ { "id": "G3V8Y5_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Y5", "type": "external" } ], "mass": 133897.0, "length": 1174, "protein_name": "DNA-directed RNA polymerase subunit beta", "gene_name": "Polr2b", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerase II subunit RPB2", "refseq_ac": [ { "id": "NP_001099472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099472", "type": "external" } ], "gene_names_uniprotkb": "Polr2b", "gene_names_refseq": "Polr2b; RpB2", "protein_names_uniprotkb": "DNA-directed RNA polymerase subunit beta; 2.7.7.6", "protein_names_refseq": "DNA directed RNA polymerase II polypeptide B; DNA-directed RNA polymerase II subunit RPB2; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; polymerase (RNA) II subunit B", "tax_id": 10116, "disease": "", "pathway": " (rno:289561); (R-RNO-112382); (R-RNO-113418); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 23, "publication_count": 1, "publication_id_list": "25568312", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that activation of RNA polymerase II and p70 S6 kinase (P70S6K) are increased in apoptotic neurons, and their inhibition prevents apoptosis., [RefSeq, PubMed]; RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" } ], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0000781 chromosome, telomeric region;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006354 DNA-templated transcription elongation;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8Y5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Z3-1", "uniprot_id": [ { "id": "G3V8Z3_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Z3", "type": "external" } ], "mass": 53259.0, "length": 487, "protein_name": "G-patch domain and KOW motifs-containing protein", "gene_name": "Gpkow", "organism": "Rat", "refseq_name": "G-patch domain and KOW motifs-containing protein", "refseq_ac": [ { "id": "NP_001102851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102851", "type": "external" } ], "gene_names_uniprotkb": "Gpkow", "gene_names_refseq": "Gpkow", "protein_names_uniprotkb": "G-patch domain and KOW motifs-containing protein", "protein_names_refseq": "G patch domain and KOW motifs-containing protein; G-patch domain and KOW motifs-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:679890); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071018 U12-type catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V901-1", "uniprot_id": [ { "id": "G3V901_RAT", "url": "https://www.uniprot.org/uniprot/G3V901", "type": "external" } ], "mass": 86308.0, "length": 746, "protein_name": "Exostosin-1", "gene_name": "Ext1", "organism": "Rat", "refseq_name": "exostosin-1", "refseq_ac": [ { "id": "NP_001124012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124012", "type": "external" } ], "gene_names_uniprotkb": "Ext1", "gene_names_refseq": "Ext1", "protein_names_uniprotkb": "Exostosin-1; 2.4.1.225; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase", "protein_names_refseq": "exostoses (multiple) 1; exostosin-1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994); chondrosarcoma (Disease Ontology:DOID:3371)", "pathway": " (rno:299907); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22339633", "class_list": "", "function": "Ext1 gene is involved in heparan sulfate proteoglycans metabolism., [RefSeq, PubMed]; Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.224", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224", "type": "external" }, { "id": "2.4.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0051923 sulfation;GO:0060429 epithelium development;GO:0043931 ossification involved in bone maturation;GO:0000271 polysaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V901-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V918-1", "uniprot_id": [ { "id": "G3V918_RAT", "url": "https://www.uniprot.org/uniprot/G3V918", "type": "external" } ], "mass": 107580.0, "length": 1010, "protein_name": "Trifunctional purine biosynthetic protein adenosine-3", "gene_name": "Gart", "organism": "Rat", "refseq_name": "trifunctional purine biosynthetic protein adenosine-3", "refseq_ac": [ { "id": "NP_001011899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011899", "type": "external" } ], "gene_names_uniprotkb": "Gart", "gene_names_refseq": "Gart", "protein_names_uniprotkb": "Trifunctional purine biosynthetic protein adenosine-3; 5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GART; Glycinamide ribonucleotide synthetase; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide synthetase", "protein_names_refseq": "trifunctional purine biosynthetic protein adenosine-3", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:288259); (R-RNO-73817)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "24709117;29393594", "class_list": "", "function": "After spinal cord injury, GART expression was increased in astrocytes, correlated with the highly expressed proliferating cell nuclear antigen. Knockdown of GART expression in astrocytes revealed that it plays a role in pro-inflammatory factors., [RefSeq, PubMed]; Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.2", "type": "external" }, { "id": "6.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.3.1", "type": "external" }, { "id": "6.3.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004637 phosphoribosylamine-glycine ligase activity;GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644 phosphoribosylglycinamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0003360 brainstem development;GO:0021987 cerebral cortex development;GO:0021549 cerebellum development;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V918-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V953-1", "uniprot_id": [ { "id": "G3V953_RAT", "url": "https://www.uniprot.org/uniprot/G3V953", "type": "external" } ], "mass": 199849.0, "length": 1789, "protein_name": "E3 ubiquitin-protein ligase RBBP6", "gene_name": "Rbbp6", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RBBP6 isoform X2", "refseq_ac": [ { "id": "XP_219296", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_219296", "type": "external" } ], "gene_names_uniprotkb": "Rbbp6", "gene_names_refseq": "Rbbp6", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RBBP6; 2.3.2.27; Proliferation potential-related protein; Protein P2P-R; RING-type E3 ubiquitin transferase RBBP6; Retinoblastoma-binding protein 6; p53-associated cellular protein of testis", "protein_names_refseq": "E3 ubiquitin-protein ligase RBBP6 isoform X2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (R-RNO-9013422); (R-RNO-9770562); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0061630 ubiquitin protein ligase activity;GO:0019901 protein kinase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0016567 protein ubiquitination;GO:0006275 regulation of DNA replication;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V953-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V970-1", "uniprot_id": [ { "id": "G3V970_RAT", "url": "https://www.uniprot.org/uniprot/G3V970", "type": "external" } ], "mass": 32210.0, "length": 284, "protein_name": "SIX homeobox 1", "gene_name": "Six1", "organism": "Rat", "refseq_name": "homeobox protein SIX1", "refseq_ac": [ { "id": "NP_446211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446211", "type": "external" } ], "gene_names_uniprotkb": "Six1", "gene_names_refseq": "Six1", "protein_names_uniprotkb": "SIX homeobox 1", "protein_names_refseq": "homeobox protein SIX1; sine oculis homeobox homolog 1; sine oculis-related homeobox 1 homolog", "tax_id": 10116, "disease": "branchiootic syndrome 3 (Disease Ontology:DOID:0061210); autosomal dominant nonsyndromic deafness 23 (Disease Ontology:DOID:0110553); branchiootorenal syndrome (Disease Ontology:DOID:14702); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); neurilemmoma (Disease Ontology:DOID:3192); ovarian carcinoma (Disease Ontology:DOID:4001); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:114634)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "35180623;37479098", "class_list": "", "function": "SIX1 attenuates inflammation and rheumatoid arthritis by silencing MyD88-dependent TLR1/2 signaling., [RefSeq, PubMed]; SIX1 induced HULC modulates neuropathic pain and Schwann cell oxidative stress after sciatic nerve injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0001759 organ induction;GO:0050678 regulation of epithelial cell proliferation;GO:0086100 endothelin receptor signaling pathway;GO:0061055 myotome development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V970-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V972-1", "uniprot_id": [ { "id": "G3V972_RAT", "url": "https://www.uniprot.org/uniprot/G3V972", "type": "external" } ], "mass": 18766.0, "length": 166, "protein_name": "Gem-associated protein 6", "gene_name": "Gemin6", "organism": "Rat", "refseq_name": "gem-associated protein 6 isoform 1", "refseq_ac": [ { "id": "NP_001009466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009466", "type": "external" } ], "gene_names_uniprotkb": "Gemin6", "gene_names_refseq": "Gemin6", "protein_names_uniprotkb": "Gem-associated protein 6", "protein_names_refseq": "gem-associated protein 6 isoform 1; gem-associated protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:362688); (R-RNO-191859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0032797 SMN complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V972-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V977-1", "uniprot_id": [ { "id": "G3V977_RAT", "url": "https://www.uniprot.org/uniprot/G3V977", "type": "external" } ], "mass": 20437.0, "length": 175, "protein_name": "Bcl-2-related protein A1", "gene_name": "Bcl2a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bcl2a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Bcl-2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0044877 protein-containing complex binding;GO:0051400 BH domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0021987 cerebral cortex development;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0001836 release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V977-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V979-1", "uniprot_id": [ { "id": "G3V979_RAT", "url": "https://www.uniprot.org/uniprot/G3V979", "type": "external" } ], "mass": 54714.0, "length": 494, "protein_name": "Transmembrane and coiled-coil domains 6", "gene_name": "Tmco6", "organism": "Rat", "refseq_name": "transmembrane and coiled-coil domain-containing protein 6", "refseq_ac": [ { "id": "NP_001099624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099624", "type": "external" } ], "gene_names_uniprotkb": "Tmco6", "gene_names_refseq": "RGD1309263; Tmco6", "protein_names_uniprotkb": "Transmembrane and coiled-coil domains 6", "protein_names_refseq": "transmembrane and coiled-coil domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:291661)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V979-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V996-1", "uniprot_id": [ { "id": "G3V996_RAT", "url": "https://www.uniprot.org/uniprot/G3V996", "type": "external" } ], "mass": 41967.0, "length": 360, "protein_name": "LETM1 domain containing 1", "gene_name": "Letmd1", "organism": "Rat", "refseq_name": "LETM1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001116253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116253", "type": "external" } ], "gene_names_uniprotkb": "Letmd1", "gene_names_refseq": "Letmd1; RGD1310591", "protein_names_uniprotkb": "LETM1 domain containing 1", "protein_names_refseq": "LETM1 domain-containing protein 1", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); uterine cancer (Disease Ontology:DOID:363); ovarian carcinoma (Disease Ontology:DOID:4001); renal carcinoma (Disease Ontology:DOID:4451); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:681352)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1903409 reactive oxygen species biosynthetic process;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0006754 ATP biosynthetic process;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V996-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9E2-1", "uniprot_id": [ { "id": "G3V9E2_RAT", "url": "https://www.uniprot.org/uniprot/G3V9E2", "type": "external" } ], "mass": 26747.0, "length": 238, "protein_name": "Probable RNA/DNA demethylase ALKBH6", "gene_name": "Alkbh6", "organism": "Rat", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase alkB homolog 6", "refseq_ac": [ { "id": "NP_001120922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120922", "type": "external" } ], "gene_names_uniprotkb": "Alkbh6; LOC100912458", "gene_names_refseq": "Alkbh6", "protein_names_uniprotkb": "Probable RNA/DNA demethylase ALKBH6; Alkylated DNA repair protein alkB homolog 6; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6", "protein_names_refseq": "alkB, alkylation repair homolog 6; alkylated DNA repair protein alkB homolog 6; alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; probable alpha-ketoglutarate-dependent dioxygenase ABH6", "tax_id": 10116, "disease": "", "pathway": " (rno:292780)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids. Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs. May play a role in nucleic acid damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9G8-1", "uniprot_id": [ { "id": "G3V9G8_RAT", "url": "https://www.uniprot.org/uniprot/G3V9G8", "type": "external" } ], "mass": 44715.0, "length": 395, "protein_name": "NFKB activating protein-like", "gene_name": "Nkapl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nkapl", "gene_names_refseq": "", "protein_names_uniprotkb": "NFKB activating protein-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "carcinoma (Disease Ontology:DOID:305)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9G8-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9L9-1", "uniprot_id": [ { "id": "G3V9L9_RAT", "url": "https://www.uniprot.org/uniprot/G3V9L9", "type": "external" } ], "mass": 100047.0, "length": 905, "protein_name": "Chloride channel 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"gene_name": "Oxld1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Oxld1; LOC688310", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxidoreductase-like domain containing 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R3T0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R3W2-1", "uniprot_id": [ { "id": "M0R3W2_RAT", "url": "https://www.uniprot.org/uniprot/M0R3W2", "type": "external" } ], "mass": 25306.0, "length": 236, "protein_name": "Membrane spanning 4-domains A4A", "gene_name": "Ms4a4a", "organism": "Rat", "refseq_name": "membrane-spanning 4-domains subfamily A member 4A isoform 1", "refseq_ac": [ { "id": "NP_001419262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419262", "type": "external" } ], "gene_names_uniprotkb": "Ms4a4a", "gene_names_refseq": "Ms4a4a; Ms4a4e", "protein_names_uniprotkb": "Membrane spanning 4-domains A4A", "protein_names_refseq": "membrane spanning 4-domains A4E; membrane-spanning 4-domains subfamily A member 4A isoform 1; membrane-spanning 4-domains subfamily A member 4A-like; membrane-spanning 4-domains, subfamily A, member 4A; membrane-spanning 4-domains, subfamily A, member 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, 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"ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R3W2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R469-1", "uniprot_id": [ { "id": "M0R469_RAT", "url": "https://www.uniprot.org/uniprot/M0R469", "type": "external" } ], "mass": 20080.0, "length": 189, "protein_name": "Similar to human chromosome 5 open reading frame 24", "gene_name": "C17h5orf24", "organism": "Rat", "refseq_name": "UPF0461 protein C5orf24 homolog", "refseq_ac": [ { "id": "NP_001387699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387699", "type": "external" } ], "gene_names_uniprotkb": "C17h5orf24; RGD1566359", "gene_names_refseq": "C17h5orf24; RGD1566359", "protein_names_uniprotkb": "Similar to human chromosome 5 open reading frame 24", "protein_names_refseq": "UPF0461 protein C5orf24 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498701)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, 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"gene_name": "Krtap31-2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krtap31-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin associated protein 31-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6805567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4V6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R719-1", "uniprot_id": [ { "id": "M0R719_RAT", "url": "https://www.uniprot.org/uniprot/M0R719", "type": "external" } ], "mass": 13359.0, "length": 119, "protein_name": "MICOS complex subunit MIC13", "gene_name": "Micos13", "organism": "Rat", "refseq_name": "MICOS complex subunit MIC13 precursor", "refseq_ac": [ { "id": "NP_001386131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386131", "type": "external" } ], "gene_names_uniprotkb": "Micos13; LOC301124", "gene_names_refseq": "Micos13", "protein_names_uniprotkb": "MICOS complex subunit MIC13", "protein_names_refseq": "MICOS complex subunit MIC13 precursor; MICOS complex subunit MIC13", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 37 (Disease Ontology:DOID:0111499)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R719-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7T2-1", "uniprot_id": [ { "id": "M0R7T2_RAT", "url": "https://www.uniprot.org/uniprot/M0R7T2", "type": "external" } ], "mass": 25016.0, "length": 221, "protein_name": "RNA demethylase ALKBH7, mitochondrial", "gene_name": "Alkbh7", "organism": "Rat", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial", "refseq_ac": [ { "id": "NP_001102854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102854", "type": "external" } ], "gene_names_uniprotkb": "Alkbh7", "gene_names_refseq": "Alkbh7", "protein_names_uniprotkb": "RNA demethylase ALKBH7, mitochondrial; Alkylated DNA repair protein alkB homolog 7; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial", "protein_names_refseq": "AlkB-like protein 7; alkB, alkylation repair homolog 7; alkylated DNA repair protein alkB homolog 7; alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:679944)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity. In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. Involved in fatty acid metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990984 tRNA demethylase activity;GO:0035515 oxidative RNA demethylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006974 DNA damage response;GO:0010883 regulation of lipid storage;GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:0035513 oxidative RNA demethylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R7T2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7U1-1", "uniprot_id": [ { "id": "M0R7U1_RAT", "url": "https://www.uniprot.org/uniprot/M0R7U1", "type": "external" } ], "mass": 63156.0, "length": 562, "protein_name": "Adenylate kinase isoenzyme 5", "gene_name": "Ak5", "organism": "Rat", "refseq_name": "adenylate kinase isoenzyme 5", "refseq_ac": [ { "id": "NP_001102421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102421", "type": "external" } ], "gene_names_uniprotkb": "Ak5", "gene_names_refseq": "Ak5", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 5; 2.7.4.3; 2.7.4.4; 2.7.4.6; ATP-AMP transphosphorylase 5", "protein_names_refseq": "adenylate kinase isoenzyme 5", "tax_id": 10116, "disease": "", "pathway": " (rno:365985); (R-RNO-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP., [UniProtKB, UniProtKB]; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0009188 ribonucleoside diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0R7U1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R7V6-1", "uniprot_id": [ { "id": "M0R7V6_RAT", "url": "https://www.uniprot.org/uniprot/M0R7V6", "type": "external" } ], "mass": 14413.0, "length": 123, "protein_name": "H2B.L histone variant 1", "gene_name": "H2bl1", "organism": "Rat", "refseq_name": "uncharacterized protein LOC684444", "refseq_ac": [ { "id": "NP_001396034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396034", "type": "external" } ], "gene_names_uniprotkb": "H2bl1; LOC684444", "gene_names_refseq": "H2bl1", "protein_names_uniprotkb": "H2B.L histone variant 1", "protein_names_refseq": "histone H2B subacrosomal; uncharacterized protein LOC684444", "tax_id": 10116, "disease": "", "pathway": " (rno:684444)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R7V6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R8J7-1", "uniprot_id": [ { "id": "M0R8J7_RAT", "url": "https://www.uniprot.org/uniprot/M0R8J7", "type": "external" } ], "mass": 63363.0, "length": 574, "protein_name": "Interactor of HORMAD1 1", "gene_name": "Iho1", "organism": "Rat", "refseq_name": "interactor of HORMAD1 protein 1 isoform X1", "refseq_ac": [ { "id": "XP_001055346", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001055346", "type": "external" } ], "gene_names_uniprotkb": "Iho1; Ccdc36", "gene_names_refseq": "Iho1", "protein_names_uniprotkb": "Interactor of HORMAD1 1", "protein_names_refseq": "interactor of HORMAD1 protein 1 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:680018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome", "go_biological_process": "GO:0060629 regulation of homologous chromosome segregation;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R8J7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R8V1-1", "uniprot_id": [ { "id": "M0R8V1_RAT", "url": "https://www.uniprot.org/uniprot/M0R8V1", "type": "external" } ], "mass": 10757.0, "length": 100, "protein_name": "Prostate and testis expressed 14 like 1", "gene_name": "Pate14l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pate14l1; RGD1560112", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostate and testis expressed 14 like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:363044)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R8V1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R967-1", "uniprot_id": [ { "id": "M0R967_RAT", "url": "https://www.uniprot.org/uniprot/M0R967", "type": "external" } ], "mass": 29128.0, "length": 251, "protein_name": "Prolactin family 7, subfamily c, member 1", "gene_name": "Prl7c1", "organism": "Rat", "refseq_name": "prolactin family 7, subfamily c, member 1 precursor", "refseq_ac": [ { "id": "NP_001304727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304727", "type": "external" } ], "gene_names_uniprotkb": "Prl7c1; LOC684107", "gene_names_refseq": "Ghd6; Prl7c1", "protein_names_uniprotkb": "Prolactin family 7, subfamily c, member 1", "protein_names_refseq": "growth hormone d6; prolactin family 7, subfamily c, member 1 precursor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:684107)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0046872 metal ion binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R967-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R9B9-1", "uniprot_id": [ { "id": "M0R9B9_RAT", "url": "https://www.uniprot.org/uniprot/M0R9B9", "type": "external" } ], "mass": 54837.0, "length": 490, "protein_name": "UBX domain-containing protein 7", "gene_name": "AABR07034438.1; Ubxn7", "organism": "Rat", "refseq_name": "UBX domain-containing protein 7", "refseq_ac": [ { "id": "NP_001420429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420429", "type": "external" } ], "gene_names_uniprotkb": "AABR07034438.1; Ubxn7; AABR07034438.1; Ubxn7", "gene_names_refseq": "RGD1306346; Ubxd7; Ubxn7", "protein_names_uniprotkb": "UBX domain-containing protein 7", "protein_names_refseq": "UBX domain containing 7; UBX domain-containing protein 7", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664); (R-RNO-9755511)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R9B9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R9D3-1", "uniprot_id": [ { "id": "M0R9D3_RAT", "url": "https://www.uniprot.org/uniprot/M0R9D3", "type": "external" } ], "mass": 39032.0, "length": 349, "protein_name": "Protein Wnt", "gene_name": "Wnt7a", "organism": "Rat", "refseq_name": "protein Wnt-7a", "refseq_ac": [ { "id": "NP_001093943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093943", "type": "external" } ], "gene_names_uniprotkb": "Wnt7a", "gene_names_refseq": "Wnt7a", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "protein Wnt-7a; wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family, member 7A", "tax_id": 10116, "disease": "Fuhrmann syndrome (Disease Ontology:DOID:0090067); Schinzel type phocomelia (Disease Ontology:DOID:0112181); leiomyoma (Disease Ontology:DOID:127)", "pathway": " (rno:114850); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "31852613;32949181;38597273", "class_list": "", "function": "Differential changes in Wnt7 and Dkk1 levels in astrocytes exposed to glutamate or TNFalpha., [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5., [UniProtKB, UniProtKB]; Wingless ligands and beta-catenin expression in the rat endometrium: The role of Wnt3 and Wnt7a/beta-catenin pathway at the embryo-uterine interface., [RefSeq, PubMed]; Wnt7a regulates high autophagic and inflammatory response of epidermis in high-glucose environment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0098793 presynapse", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0000578 embryonic axis specification;GO:0060856 establishment of blood-brain barrier;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0R9D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAN3-1", "uniprot_id": [ { "id": "M0RAN3_RAT", "url": "https://www.uniprot.org/uniprot/M0RAN3", "type": "external" } ], "mass": 35163.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or8b51b", "organism": "Rat", "refseq_name": "olfactory receptor Olr1239", "refseq_ac": [ { "id": "NP_001000811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000811", "type": "external" } ], "gene_names_uniprotkb": "Or8b51b; LOC100912022", "gene_names_refseq": "Olr1239; Or8b51b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1239; olfactory receptor 8B3-like; olfactory receptor Olr1239; olfactory receptor gene Olr1239", "tax_id": 10116, "disease": "", "pathway": " (rno:405097)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RAN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAP1-1", "uniprot_id": [ { "id": "M0RAP1_RAT", "url": "https://www.uniprot.org/uniprot/M0RAP1", "type": "external" } ], "mass": 36110.0, "length": 338, "protein_name": "Undifferentiated embryonic cell transcription factor 1", "gene_name": "Utf1", "organism": "Rat", "refseq_name": "undifferentiated embryonic cell transcription factor 1", "refseq_ac": [ { "id": "NP_001124504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124504", "type": "external" } ], "gene_names_uniprotkb": "Utf1", "gene_names_refseq": "Utf1", "protein_names_uniprotkb": "Undifferentiated embryonic cell transcription factor 1", "protein_names_refseq": "undifferentiated embryonic cell transcription factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:681901)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0071837 HMG box domain binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RAP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RB48-1", "uniprot_id": [ { "id": "M0RB48_RAT", "url": "https://www.uniprot.org/uniprot/M0RB48", "type": "external" } ], "mass": 35087.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "Or51h1", "organism": "Rat", "refseq_name": "similar to olfactory receptor 555", "refseq_ac": [ { "id": "NP_001396070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396070", "type": "external" } ], "gene_names_uniprotkb": "Or51h1", "gene_names_refseq": "Or51h1", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 51H1; 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LOC498122", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:1900272 negative regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RBE6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RBF6-1", "uniprot_id": [ { "id": "M0RBF6_RAT", "url": "https://www.uniprot.org/uniprot/M0RBF6", "type": "external" } ], "mass": 34599.0, "length": 310, "protein_name": "Olfactory receptor", "gene_name": "Or10j2", "organism": "Rat", "refseq_name": "similar to olfactory receptor 1403", "refseq_ac": [ { "id": "NP_001396068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396068", "type": "external" } ], "gene_names_uniprotkb": "Or10j2", "gene_names_refseq": "Or10j2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 10J1; 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frizzled-3 precursor; frizzled-3", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (R-RNO-4086398); (R-RNO-4086400); (R-RNO-4608870)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "31145996", "class_list": "", "function": "Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3. Erratum:[Cell Signal. 2019 Dec;64:109396. 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