[ { "uniprot_canonical_ac": "Q8C7K6-1", "uniprot_id": [ { "id": "PCYXL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C7K6", "type": "external" } ], "mass": 54875.0, "length": 495, "protein_name": "Prenylcysteine oxidase 1-like", "gene_name": "Pcyox1l", "organism": "Mouse", "refseq_name": "prenylcysteine oxidase 1-like isoform 1 precursor", "refseq_ac": [ { "id": "NP_766420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766420", "type": "external" } ], "gene_names_uniprotkb": "Pcyox1l", "gene_names_refseq": "C630049M13; Pcyox1l", "protein_names_uniprotkb": "Prenylcysteine oxidase 1-like; 1.8.3.5", "protein_names_refseq": "prenylcysteine oxidase 1-like isoform 1 precursor; prenylcysteine oxidase-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:240334); (R-MMU-114608)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;37179332;40712023", "class_list": "", "function": "Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities. Publication Status: Online-Only, [RefSeq, PubMed]; Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Does not metabolize shorter prenyl chain compounds (By similarity). Required in the mevalonate pathway to regulate prenylation and enhances the bactericidal activity of neutrophils (PubMed:37179332). Promotes the assembly of the postsynaptic ion channel ASIC1a (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0001735 prenylcysteine oxidase activity;GO:0102149 farnesylcysteine lyase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0070944 neutrophil-mediated killing of bacterium;GO:0030328 prenylcysteine catabolic process;GO:0030327 prenylated protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C7K6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2F7-1", "uniprot_id": [ { "id": "P210L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2F7", "type": "external" } ], "mass": 208700.0, "length": 1881, "protein_name": "Nuclear pore membrane glycoprotein 210-like", "gene_name": "Nup210l", "organism": "Mouse", "refseq_name": "nuclear pore membrane glycoprotein 210-like precursor", "refseq_ac": [ { "id": "NP_084213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084213", "type": "external" } ], "gene_names_uniprotkb": "Nup210l", "gene_names_refseq": "4930548O11Rik; Nup210l; R26-EGFP; Tg(Gt(ROSA)26Sor-EGFP)130910Eps", "protein_names_uniprotkb": "Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 kDa-like; Nucleoporin Nup210-like", "protein_names_refseq": "nuclear pore membrane glycoprotein 210-like precursor; nuclear pore membrane glycoprotein 210-like; nucleoporin 210 kDa-like; nucleoporin Nup210-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:77595)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26495903;38129135", "class_list": "", "function": "Spermatozoa in mice lacking the nucleoporin NUP210L show defects in head shape and motility but not in nuclear compaction or histone replacement., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007286 spermatid development;GO:0060009 Sertoli cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D2F7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08003-1", "uniprot_id": [ { "id": "PDIA4_MOUSE", "url": "https://www.uniprot.org/uniprot/P08003", "type": "external" } ], "mass": 71982.0, "length": 638, "protein_name": "Protein disulfide-isomerase A4", "gene_name": "Pdia4", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase A4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_033917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033917", "type": "external" } ], "gene_names_uniprotkb": "Pdia4; Cai; Erp72", "gene_names_refseq": "Cai; ERp-72; Erp72; Pdia4", "protein_names_uniprotkb": "Protein disulfide-isomerase A4; 5.3.4.1; ER protein 72; ERp-72; ERp72; Endoplasmic reticulum resident protein 72", "protein_names_refseq": "ER protein 72; calcium binding protein, intestinal; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 72; protein disulfide-isomerase A4 isoform 2 precursor; protein disulfide-isomerase A4", "tax_id": 10090, "disease": "", "pathway": " (mmu:12304)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "12475965;20173027;21750661;22872234;2295602;23956175;25428506;26495903;30779550;3320970;34203471;34428180;35820727;35984892;37453647;37507081;37828378;38205640", "class_list": "", "function": "Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P15841;Q3TT79;Q3UJW0;Q6NXW4;Q8BMT8", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:1903334 positive regulation of protein folding;GO:0006457 protein folding;GO:0070527 platelet aggregation;GO:0034976 response to endoplasmic reticulum stress;GO:0072378 blood coagulation, fibrin clot formation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P08003-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAN1-1", "uniprot_id": [ { "id": "PDILT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAN1", "type": "external" } ], "mass": 67759.0, "length": 588, "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "Pdilt", "organism": "Mouse", "refseq_name": "protein disulfide-isomerase-like protein of the testis precursor", "refseq_ac": [ { "id": "NP_082219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082219", "type": "external" } ], "gene_names_uniprotkb": "Pdilt", "gene_names_refseq": "1700007B13Rik; Pdilt", "protein_names_uniprotkb": "Protein disulfide-isomerase-like protein of the testis", "protein_names_refseq": "protein disulfide-isomerase-like protein of the testis precursor; protein disulfide-isomerase-like protein of the testis", "tax_id": 10090, "disease": "", "pathway": " (mmu:71830)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15475357;17507649;21750661;22357757", "class_list": "", "function": "Probable redox-inactive chaperone involved in spermatogenesis., [UniProtKB]; Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility Erratum:[Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5905], [RefSeq, PubMed]; The expression of PDILT, in addition to PDI in the testis, suggests that PDILT performs a specialized chaperone function in testicular cells. [PDILT], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016477 cell migration;GO:0007286 spermatid development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DAN1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61139-1", "uniprot_id": [ { "id": "PCSK7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61139", "type": "external" } ], "mass": 84358.0, "length": 770, "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "Pcsk7", "organism": "Mouse", "refseq_name": "proprotein convertase subtilisin/kexin type 7 precursor", "refseq_ac": [ { "id": "NP_001268863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268863", "type": "external" } ], "gene_names_uniprotkb": "Pcsk7; Pc7", "gene_names_refseq": "PC7; Pcsk7; SPC7", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 7; 3.4.21.-; PC7; Prohormone convertase 7; Proprotein convertase 7; SPC7; Subtilisin-like proprotein convertase 7; Subtilisin/kexin-like protease PC7", "protein_names_refseq": "prohormone convertase 7; prohormone convertase PC7; proprotein convertase PC7; proprotein convertase subtilisin/kexin type 7 precursor; subtilisin-like proprotein convertase 7; subtilisin/kexin-like protease PC7", "tax_id": 10090, "disease": "", "pathway": " (mmu:18554); (R-MMU-9768727)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;24101515;26416966;27923657;31219806;34428180;37967646;8698813", "class_list": "", "function": "Data show that BDNF and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice., [RefSeq, PubMed]; PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation., [RefSeq, PubMed]; PC7 has a critical role in normal processing of cholecystokinin in mouse brain, [RefSeq, PubMed]; PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Erratum:[Metabolism. 2024 Dec;161:156032. doi: 10.1016/j.metabol.2024.156032. PMID: 39298889], [RefSeq, PubMed]; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O08577;Q922W4", "ec_number_list": [ { "id": "3.4.21.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.94", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005788 endoplasmic reticulum lumen;GO:0005802 trans-Golgi network;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q61139-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMM8-1", "uniprot_id": [ { "id": "PAR16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMM8", "type": "external" } ], "mass": 36764.0, "length": 322, "protein_name": "Protein mono-ADP-ribosyltransferase PARP16", "gene_name": "Parp16", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP16", "refseq_ac": [ { "id": "NP_803411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803411", "type": "external" } ], "gene_names_uniprotkb": "Parp16; Artd15", "gene_names_refseq": "ARTD15; PARP-16; Parp16", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP16; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; Poly [ADP-ribose] polymerase 16", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 15; mono [ADP-ribose] polymerase PARP16; poly [ADP-ribose] polymerase 16; protein mono-ADP-ribosyltransferase PARP16", "tax_id": 10090, "disease": "", "pathway": " (mmu:214424)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22661712;25605945;34428180;36692424", "class_list": "", "function": "ADP-ribose transferase PARP16 mediated-unfolded protein response contributes to neuronal cell damage in cerebral ischemia/reperfusion., [RefSeq, PubMed]; ARTD15 features an alpha-helical domain that packs against its transferase domain without making direct contact with the NAD(+)-binding crevice or the donor loop., [RefSeq, PubMed]; Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V031;Q8CC71", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0036498 IRE1-mediated unfolded protein response;GO:1990830 cellular response to leukemia inhibitory factor;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TMM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922E4-1", "uniprot_id": [ { "id": "PCY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922E4", "type": "external" } ], "mass": 45235.0, "length": 404, "protein_name": "Ethanolamine-phosphate cytidylyltransferase", "gene_name": "Pcyt2", "organism": "Mouse", "refseq_name": "ethanolamine-phosphate cytidylyltransferase isoform 1", "refseq_ac": [ { "id": "NP_077191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077191", "type": "external" } ], "gene_names_uniprotkb": "Pcyt2", "gene_names_refseq": "1110033E03Rik; ET; Pcyt2", "protein_names_uniprotkb": "Ethanolamine-phosphate cytidylyltransferase; 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase", "protein_names_refseq": "CTP:phosphoethanolamine cytidylyltransferase; ethanolamine-phosphate cytidylyltransferase isoform 1; ethanolamine-phosphate cytidylyltransferase; phosphorylethanolamine transferase", "tax_id": 10090, "disease": "hereditary spastic paraplegia 82 (Disease Ontology:DOID:0112343)", "pathway": " (mmu:68671); (R-MMU-1483213)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17325045;17646670;21750661;30084848;34428180;35058529;36379282;36941451;37828378;40684658", "class_list": "", "function": "Alternative splicing of the mPcyt2 transcript is ubiquitous but could also be regulated in a tissue-specific manner, producing a variable ratio of mPcyt2alpha/mPcyt2beta mRNAs, [RefSeq, PubMed]; Ethanolamine-phosphate cytidylyltransferase that catalyzes the second step in the synthesis of phosphatidylethanolamine (PE) from ethanolamine via the CDP-ethanolamine pathway (PubMed:17325045). Phosphatidylethanolamine is a dominant inner-leaflet phospholipid in cell membranes, where it plays a role in membrane function by structurally stabilizing membrane-anchored proteins, and participates in important cellular processes such as cell division, cell fusion, blood coagulation, and apoptosis (PubMed:17325045)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; P75NTR enhances cognitive dysfunction in a mouse Alzheimer's disease model by inhibiting microRNA-210-3p-mediated PCYT2 through activation of NF-kappaB., [RefSeq, PubMed]; PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Erratum:[Nat Metab. 2023 Apr;5(4):711. doi: 10.1038/s42255-023-00791-1. PMID: 37024756], [RefSeq, PubMed]; Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphoethanolamine. Erratum:[Sci Rep. 2023 Jun 22;13(1):10175. doi: 10.1038/s41598-023-36725-w. PMID: 37349480] Publication Status: Online-Only, [RefSeq, PubMed]; Single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99J50", "ec_number_list": [ { "id": "2.7.7.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.14", "type": "external" } ], "go_molecular_function": "GO:0004306 ethanolamine-phosphate cytidylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q922E4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQM4-1", "uniprot_id": [ { "id": "P5I11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4QQM4", "type": "external" } ], "mass": 20911.0, "length": 189, "protein_name": "Tumor protein p53-inducible protein 11", "gene_name": "Trp53i11", "organism": "Mouse", "refseq_name": "tumor protein p53-inducible protein 11 isoform b", "refseq_ac": [ { "id": "NP_001020417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020417", "type": "external" } ], "gene_names_uniprotkb": "Trp53i11; Pig11; Tp53i11", "gene_names_refseq": "Tp53i11; Trp53i11", "protein_names_uniprotkb": "Tumor protein p53-inducible protein 11; Transformation related protein 53 inducible protein 11; p53-induced gene 11 protein", "protein_names_refseq": "Trp53 inducible protein 11 (Trp53i11); p53-induced gene 11 protein; tumor protein p53-inducible protein 11 isoform b; tumor protein p53-inducible protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:277414)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQL4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4QQM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0Y7-1", "uniprot_id": [ { "id": "PAXX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0Y7", "type": "external" } ], "mass": 21977.0, "length": 205, "protein_name": "Protein PAXX", "gene_name": "Paxx", "organism": "Mouse", "refseq_name": "protein PAXX", "refseq_ac": [ { "id": "NP_705785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705785", "type": "external" } ], "gene_names_uniprotkb": "Paxx; BC029214", "gene_names_refseq": "D930050G13Rik; Paxx", "protein_names_uniprotkb": "Protein PAXX; Paralog of XRCC4 and XLF", "protein_names_refseq": "paralog of XRCC4 and XLF; protein PAXX", "tax_id": 10090, "disease": "", "pathway": " (mmu:227622)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "21750661;27601299;27601633;27798842;27830975;28051062;29077092;29511619;29511621;33379193", "class_list": "", "function": "Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population. Publication Status: Online-Only, [RefSeq, PubMed]; Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:27601299, PubMed:27601633, PubMed:27798842, PubMed:27830975, PubMed:28051062, PubMed:29077092). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:28051062). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (By similarity). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (By similarity). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27601299, PubMed:27798842, PubMed:27830975, PubMed:28051062)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PAXX and XLF proteins may have redundant functions during Non-homologous end joining., [RefSeq, PubMed]; Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, [RefSeq, PubMed]; Study reports that PAXX is dispensable for physiological non-homologous end-joining (NHEJ) in otherwise wild-type mice. Yet Paxx(-/-) mice require XLF and Xlf(-/-) mice require PAXX for end-ligation revealing distinct, yet critically complementary functions of PAXX and XLF during NHEJ. Publication Status: Online-Only, [RefSeq, PubMed]; We also find that PAXX deficiency has no impact on V(D)J recombination DSB joining in ATM-deficient pro-B lines. We discuss implications of these findings with respect to potential PAXX and XLF functions in C-NHEJ., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C6V7", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0043564 Ku70:Ku80 complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K0Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09084-1", "uniprot_id": [ { "id": "PAX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P09084", "type": "external" } ], "mass": 46263.0, "length": 446, "protein_name": "Paired box protein Pax-1", "gene_name": "Pax1", "organism": "Mouse", "refseq_name": "paired box protein Pax-1", "refseq_ac": [ { "id": "NP_032806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032806", "type": "external" } ], "gene_names_uniprotkb": "Pax1; Pax-1", "gene_names_refseq": "Pax-1; Pax1; hbs; hunchback; undulated; un; wt", "protein_names_uniprotkb": "Paired box protein Pax-1", "protein_names_refseq": "paired box gene 1; paired box protein Pax-1; wavy tail", "tax_id": 10090, "disease": "branchiootorenal syndrome (Disease Ontology:DOID:14702)", "pathway": " (mmu:18503)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1889089;21750661;2453291;31219806;3180219;38461417", "class_list": "", "function": "Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality., [RefSeq, PubMed]; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ALJ9;Q9R2B1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0009792 embryo development ending in birth or egg hatching;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0060017 parathyroid gland development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09084-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48076-1", "uniprot_id": [ { "id": "PA2GC_MOUSE", "url": "https://www.uniprot.org/uniprot/P48076", "type": "external" } ], "mass": 16983.0, "length": 150, "protein_name": "Group IIC secretory phospholipase A2", "gene_name": "Pla2g2c", "organism": "Mouse", "refseq_name": "group IIC secretory phospholipase A2 precursor", "refseq_ac": [ { "id": "NP_032894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032894", "type": "external" } ], "gene_names_uniprotkb": "Pla2g2c", "gene_names_refseq": "Pla2g2c", "protein_names_uniprotkb": "Group IIC secretory phospholipase A2; 14 kDa phospholipase A2; 3.1.1.4; GIIC sPLA2; PLA2-8; Phosphatidylcholine 2-acylhydrolase 2C; sPLA2-IIC", "protein_names_refseq": "14 kDa phospholipase A2; GIIC sPLA2; PLA2-8; group IIC secretory phospholipase A2 precursor; group IIC secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2C; sPLA2-IIC", "tax_id": 10090, "disease": "", "pathway": " (mmu:18781)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;8083202;9057094", "class_list": "", "function": "PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Testis PA2 may be important in the production of prostaglandins, by the release of arachidonic acid, which in turn are necessary for the contractions of the seminiferous tubules and the testicular capsule; they also seem to decrease sperm transit time through the male reproductive tract., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48076-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08976-1", "uniprot_id": [ { "id": "PBAS_MOUSE", "url": "https://www.uniprot.org/uniprot/O08976", "type": "external" } ], "mass": 20372.0, "length": 174, "protein_name": "Probasin", "gene_name": "Pbsn", "organism": "Mouse", "refseq_name": "probasin precursor", "refseq_ac": [ { "id": "NP_059499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059499", "type": "external" } ], "gene_names_uniprotkb": "Pbsn; Prbs", "gene_names_refseq": "PB; Pbsn; Prbs", "protein_names_uniprotkb": "Probasin; PB", "protein_names_refseq": "probasin precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:54192)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17316977;21750661", "class_list": "", "function": "Androgen receptor DNA binding domain is able to bind to its cognate sequences within the probasin promoter in a way that is indifferent to the presence or absence of histones and nucleosomal structure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08976-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7R7-1", "uniprot_id": [ { "id": "PEPC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7R7", "type": "external" } ], "mass": 42849.0, "length": 392, "protein_name": "Gastricsin", "gene_name": "Pgc", "organism": "Mouse", "refseq_name": "gastricsin precursor", "refseq_ac": [ { "id": "NP_080249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080249", "type": "external" } ], "gene_names_uniprotkb": "Pgc; Upg1", "gene_names_refseq": "2210410L06Rik; Pgc; Upg-1; Upg1", "protein_names_uniprotkb": "Gastricsin; 3.4.23.3; Pepsinogen C", "protein_names_refseq": "gastricsin precursor; gastricsin; pepsinogen C; urinary pepsinogen 1", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:109820)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;37291517", "class_list": "", "function": "Hydrolyzes a variety of proteins., [UniProtKB]; The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7T2", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion;GO:0002803 positive regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7R7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQX0-1", "uniprot_id": [ { "id": "OTUB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQX0", "type": "external" } ], "mass": 27300.0, "length": 234, "protein_name": "Ubiquitin thioesterase OTUB2", "gene_name": "Otub2", "organism": "Mouse", "refseq_name": "ubiquitin thioesterase OTUB2 isoform 1", "refseq_ac": [ { "id": "NP_001171312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171312", "type": "external" } ], "gene_names_uniprotkb": "Otub2", "gene_names_refseq": "2010015L18Rik; 4930586I02Rik; OTB2; OTU2; Otub2", "protein_names_uniprotkb": "Ubiquitin thioesterase OTUB2; 3.4.19.12; Deubiquitinating enzyme OTUB2; OTU domain-containing ubiquitin aldehyde-binding protein 2; Otubain-2; Ubiquitin-specific-processing protease OTUB2", "protein_names_refseq": "OTU domain-containing ubiquitin aldehyde-binding protein 2; deubiquitinating enzyme OTUB2; otubain-2; ubiquitin thioesterase OTUB2 isoform 1; ubiquitin thioesterase OTUB2; ubiquitin-specific-processing protease OTUB2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68149); (R-MMU-5689896)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;23515685", "class_list": "", "function": "Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity)., [UniProtKB]; SiRNAs of OTUB2 impaired insulin secretion both under basal conditions and in cytokine-treated MIN6 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUZ2;Q9D4K8", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0070536 protein K63-linked deubiquitination;GO:0071108 protein K48-linked deubiquitination;GO:0035871 protein K11-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSQ8-1", "uniprot_id": [ { "id": "PDPR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSQ8", "type": "external" } ], "mass": 99230.0, "length": 878, "protein_name": "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "gene_name": "Pdpr", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_938050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_938050", "type": "external" } ], "gene_names_uniprotkb": "Pdpr; Kiaa1990", "gene_names_refseq": "4930402E16Rik; Pdpr; mKIAA1990", "protein_names_uniprotkb": "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr", "protein_names_refseq": "pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor; pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:319518); (R-MMU-204174)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25428506;30084848;31219806;34428180", "class_list": "", "function": "Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0140176 positive regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TSQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60963-1", "uniprot_id": [ { "id": "PAFA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60963", "type": "external" } ], "mass": 49258.0, "length": 440, "protein_name": "Platelet-activating factor acetylhydrolase", "gene_name": "Pla2g7", "organism": "Mouse", "refseq_name": "platelet-activating factor acetylhydrolase precursor", "refseq_ac": [ { "id": "NP_038765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038765", "type": "external" } ], "gene_names_uniprotkb": "Pla2g7; Pafah", "gene_names_refseq": "PAF-AH; Pla2g7", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; 3.1.1.47; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase", "protein_names_refseq": "1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase; platelet-activating factor acetylhydrolase precursor; platelet-activating factor acetylhydrolase", "tax_id": 10090, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); nephrotic syndrome (Disease Ontology:DOID:1184); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); carotid stenosis (Disease Ontology:DOID:13001); dementia (Disease Ontology:DOID:1307); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); cerebral infarction (Disease Ontology:DOID:3526); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:27226); (R-MMU-422085)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10066756;11833932;12551946;16371369;18250455;18434304;20531249;21750661;25428506;26495903;27802388;34428180;35662628;37397012;37828378;7592717", "class_list": "", "function": "Deletion of both subunits induces a marked loss of germ cells at an early spermatogenic stage., [RefSeq, PubMed]; Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis., [RefSeq, PubMed]; Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:18434304). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10066756, PubMed:18434304). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:18434304). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in lipoprotein particles and uncontrolled pro-inflammatory effects (By similarity). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PAF acetylhydrolase activity in the uterus in early pregnancy was not produced locally but probably resulted from the influx of the plasma form of the enzyme, [RefSeq, PubMed]; PAF acetylhydrolases play key roles in the hydrolysis of F2-isoprostanes esterified on phospholipids in vivo, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 24, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKM3;Q921T4", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0004623 phospholipase A2 activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034362 low-density lipoprotein particle;GO:0005576 extracellular region", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0034440 lipid oxidation;GO:0034441 plasma lipoprotein particle oxidation;GO:0006954 inflammatory response;GO:0090026 positive regulation of monocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q60963-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IRT3-1", "uniprot_id": [ { "id": "PARI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IRT3", "type": "external" } ], "mass": 64105.0, "length": 573, "protein_name": "PCNA-interacting partner", "gene_name": "Parpbp", "organism": "Mouse", "refseq_name": "PCNA-interacting partner", "refseq_ac": [ { "id": "NP_083525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083525", "type": "external" } ], "gene_names_uniprotkb": "Parpbp; 4930547N16Rik; Pari", "gene_names_refseq": "4930547N16Rik; PARI; Parpbp", "protein_names_uniprotkb": "PCNA-interacting partner; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP", "protein_names_refseq": "PARP-1 binding protein; PCNA-interacting partner", "tax_id": 10090, "disease": "", "pathway": " (mmu:75317)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;23039964;28894029;31112734;31219806;31599954", "class_list": "", "function": "PARI is a latent modulator of stalled fork processing, which is required for stable genome inheritance under both endogenous and exogenous replication stress Publication Status: Online-Only, [RefSeq, PubMed]; Parpbp(4930547N16Rik) is strongly co-expressed with known cancer-associated genes. Publication Status: Online-Only, [RefSeq, PubMed]; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAQ9;Q3V278;Q8C0J4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005634 nucleus", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IRT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCL9-1", "uniprot_id": [ { "id": "PAPOG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PCL9", "type": "external" } ], "mass": 82957.0, "length": 739, "protein_name": "Poly(A) polymerase gamma", "gene_name": "Papolg", "organism": "Mouse", "refseq_name": "poly(A) polymerase gamma", "refseq_ac": [ { "id": "NP_766143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766143", "type": "external" } ], "gene_names_uniprotkb": "Papolg", "gene_names_refseq": "9630006B20Rik; Papolg", "protein_names_uniprotkb": "Poly(A) polymerase gamma; 2.7.7.19; PAP-gamma; Polynucleotide adenylyltransferase gamma; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme; Signal recognition particle RNA-adenylating enzyme", "protein_names_refseq": "PAP-gamma; SRP 3'-adenylating protein; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme; poly(A) polymerase gamma; polynucleotide adenylyltransferase gamma; signal recognition particle RNA-adenylating enzyme", "tax_id": 10090, "disease": "", "pathway": " (mmu:216578); (R-MMU-9770562); (R-MMU-9930044)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17242355;19144319;21750661;34428180", "class_list": "", "function": "Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZC9", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PCL9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZR7-1", "uniprot_id": [ { "id": "PDK1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZR7", "type": "external" } ], "mass": 38550.0, "length": 341, "protein_name": "Serine/threonine-protein kinase PDIK1L", "gene_name": "Pdik1l", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase PDIK1L", "refseq_ac": [ { "id": "NP_001157266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157266", "type": "external" } ], "gene_names_uniprotkb": "Pdik1l", "gene_names_refseq": "Pdik1l; stk35l2", "protein_names_uniprotkb": "Serine/threonine-protein kinase PDIK1L; 2.7.11.1; PDLIM1-interacting kinase 1-like", "protein_names_refseq": "serine/threonine-protein kinase PDIK1L", "tax_id": 10090, "disease": "", "pathway": " (mmu:230809)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9L0;Q3URF0;Q8BKB3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010972 negative regulation of G2/M transition of mitotic cell cycle;GO:0110031 negative regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8QZR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQF9-1", "uniprot_id": [ { "id": "PCYOX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQF9", "type": "external" } ], "mass": 56495.0, "length": 505, "protein_name": "Prenylcysteine oxidase 1", "gene_name": "Pcyox1", "organism": "Mouse", "refseq_name": "prenylcysteine oxidase 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080099", "type": "external" } ], "gene_names_uniprotkb": "Pcyox1; Kiaa0908; Pcly", "gene_names_refseq": "1200015P13Rik; PCL1; Pcly; Pcyox1", "protein_names_uniprotkb": "Prenylcysteine oxidase 1; 1.8.3.5; Prenylcysteine lyase", "protein_names_refseq": "prenylcysteine lyase; prenylcysteine oxidase 1 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66881)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;12151402;16944957;19349973;21750661;30899004;31219806;34428180;34548610;36210013;37453647;40885482;40997131", "class_list": "", "function": "Prenylcysteine oxidase 1, an emerging player in atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:12151402). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:12151402)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHV6;Q69ZW0;Q8BZX1", "ec_number_list": [ { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0001735 prenylcysteine oxidase activity;GO:0102149 farnesylcysteine lyase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0030328 prenylcysteine catabolic process;GO:0030327 prenylated protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q9CQF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C966-1", "uniprot_id": [ { "id": "PF21B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C966", "type": "external" } ], "mass": 53002.0, "length": 487, "protein_name": "PHD finger protein 21B", "gene_name": "Phf21b", "organism": "Mouse", "refseq_name": "PHD finger protein 21B isoform 1", "refseq_ac": [ { "id": "NP_001074635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074635", "type": "external" } ], "gene_names_uniprotkb": "Phf21b", "gene_names_refseq": "A730032D07Rik; Phf21b", "protein_names_uniprotkb": "PHD finger protein 21B", "protein_names_refseq": "PHD finger protein 21B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:271305)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;32820037;35866480", "class_list": "", "function": "Phf21b imprints the spatiotemporal epigenetic switch essential for neural stem cell differentiation., [RefSeq, PubMed]; The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C966-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80205-1", "uniprot_id": [ { "id": "OTX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P80205", "type": "external" } ], "mass": 37532.0, "length": 355, "protein_name": "Homeobox protein OTX1", "gene_name": "Otx1", "organism": "Mouse", "refseq_name": "homeobox protein OTX1", "refseq_ac": [ { "id": "NP_035153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035153", "type": "external" } ], "gene_names_uniprotkb": "Otx1; Otx-1", "gene_names_refseq": "A730044F23Rik; Otx1; jv", "protein_names_uniprotkb": "Homeobox protein OTX1; Orthodenticle homolog 1", "protein_names_refseq": "homeobox protein OTX1; orthodenticle homolog 1", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (mmu:18423)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1353865;21750661;8101484", "class_list": "", "function": "Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'., [UniProtKB]; This gene encodes a member of the bicoid subfamily of the paired homeobox transcription factor family. The encoded protein is critical to the maintenance and regionalization of the forebrain and midbrain during development. It may also have important functions in sense organ development, pituitary function, and in the regulation of blood cell production. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048852 diencephalon morphogenesis;GO:0022037 metencephalon development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P80205-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H9-1", "uniprot_id": [ { "id": "PHOP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2H9", "type": "external" } ], "mass": 29911.0, "length": 267, "protein_name": "Phosphoethanolamine/phosphocholine phosphatase", "gene_name": "Phospho1", "organism": "Mouse", "refseq_name": "phosphoethanolamine/phosphocholine phosphatase", "refseq_ac": [ { "id": "NP_694744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694744", "type": "external" } ], "gene_names_uniprotkb": "Phospho1", "gene_names_refseq": "D11Moh36; Phospho1; Phospo1", "protein_names_uniprotkb": "Phosphoethanolamine/phosphocholine phosphatase; 3.1.3.75", "protein_names_refseq": "phosphoethanolamine/phosphocholine phosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:237928); (R-MMU-1483191); (R-MMU-1483213)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12464021;17227223;20684022;21750661;26457330;32554489;33140469;35900032;36540015", "class_list": "", "function": "Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery., [RefSeq, PubMed]; Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy. Publication Status: Online-Only, [RefSeq, PubMed]; PHOSPHO1 localization is restricted to mineralizing regions of bone and growth plate, [RefSeq, PubMed]; Phosphatase orphan 1 inhibits myoblast proliferation and promotes myogenic differentiation., [RefSeq, PubMed]; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:17227223). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:20684022, PubMed:26457330)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A619", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.75", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0052731 phosphocholine phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0031012 extracellular matrix;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0035630 bone mineralization involved in bone maturation;GO:0030500 regulation of bone mineralization;GO:0030282 bone mineralization;GO:0001958 endochondral ossification", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R2H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27664-1", "uniprot_id": [ { "id": "PDE6A_MOUSE", "url": "https://www.uniprot.org/uniprot/P27664", "type": "external" } ], "mass": 99530.0, "length": 859, "protein_name": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha", "gene_name": "Pde6a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pde6a; Mpa; Pdea", "gene_names_refseq": "", "protein_names_uniprotkb": "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; 3.1.4.35; GMP-PDE alpha", "protein_names_refseq": "", "tax_id": 10090, "disease": "retinitis pigmentosa 43 (Disease Ontology:DOID:0110379); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (R-MMU-2485179); (R-MMU-2514859); (R-MMU-4086398)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1847109;21750661;30779550", "class_list": "", "function": "Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (By similarity). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q673", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P27664-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47242-1", "uniprot_id": [ { "id": "PAX9_MOUSE", "url": "https://www.uniprot.org/uniprot/P47242", "type": "external" } ], "mass": 36389.0, "length": 342, "protein_name": "Paired box protein Pax-9", "gene_name": "Pax9", "organism": "Mouse", "refseq_name": "paired box protein Pax-9", "refseq_ac": [ { "id": "NP_035171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035171", "type": "external" } ], "gene_names_uniprotkb": "Pax9; Pax-9", "gene_names_refseq": "Pax-9; Pax9", "protein_names_uniprotkb": "Paired box protein Pax-9", "protein_names_refseq": "paired box gene 9; paired box protein Pax-9", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591)", "pathway": " (mmu:18511)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "7649395;8358169;9732271", "class_list": "", "function": "This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P47242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59913-1", "uniprot_id": [ { "id": "PCMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P59913", "type": "external" } ], "mass": 40693.0, "length": 357, "protein_name": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "gene_name": "Pcmtd1", "organism": "Mouse", "refseq_name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "NP_898849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898849", "type": "external" } ], "gene_names_uniprotkb": "Pcmtd1", "gene_names_refseq": "8430411F12Rik; A030012M09Rik; Pcmtd1", "protein_names_uniprotkb": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "protein_names_refseq": "protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:319263)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59913-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86547-1", "uniprot_id": [ { "id": "OSTC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P86547", "type": "external" } ], "mass": 10459.0, "length": 95, "protein_name": "Osteocalcin-2", "gene_name": "Bglap2", "organism": "Mouse", "refseq_name": "osteocalcin-2 preproprotein", "refseq_ac": [ { "id": "NP_001027469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027469", "type": "external" } ], "gene_names_uniprotkb": "Bglap2", "gene_names_refseq": "BGP2; Bglap1; Bglap2; Bgp; Og2; mOC-B", "protein_names_uniprotkb": "Osteocalcin-2; BGP2; Bone Gla protein 2; Gamma-carboxyglutamic acid-containing protein 2; OG2", "protein_names_refseq": "bone Gla protein 2; gamma-carboxyglutamic acid-containing protein 2; osteocalcin-2 preproprotein; osteocalcin-2", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); polycystic kidney disease (Disease Ontology:DOID:0080322); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); neurofibromatosis 1 (Disease Ontology:DOID:0111253); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); vitamin K deficiency bleeding (Disease Ontology:DOID:11249); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); calcinosis (Disease Ontology:DOID:182); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetes insipidus (Disease Ontology:DOID:9409); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:12097); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17693256;20655470;20655471;21333348;24074871;28851741;3019668;8243336;8288580;8684484", "class_list": "", "function": "The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). The carboxylated form binds strongly to apatite and calcium (PubMed:17693256)., [UniProtKB, PubMed, PubMed]; The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a hormone that is secreted by osteoblasts and may function in bone remodeling and energy metabolism. Homozygous knockout mice for this gene exhibit a gradual increase in bone size, density and strength, as well as elevated adiposity and impaired glucose tolerance. This gene is present in a gene cluster with other related genes on chromosome 3. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04641", "ec_number_list": [], "go_molecular_function": "GO:0008147 structural constituent of bone;GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0016311 dephosphorylation;GO:1900076 regulation of cellular response to insulin stimulus;GO:1903011 negative regulation of bone development;GO:0007611 learning or memory;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P86547-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09098-1", "uniprot_id": [ { "id": "PATE4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q09098", "type": "external" } ], "mass": 11058.0, "length": 99, "protein_name": "Prostate and testis expressed protein 4", "gene_name": "Pate4", "organism": "Mouse", "refseq_name": "prostate and testis expressed protein 4 precursor", "refseq_ac": [ { "id": "NP_064660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064660", "type": "external" } ], "gene_names_uniprotkb": "Pate4; Svs7", "gene_names_refseq": "9530004K16Rik; Pate-B; Pate4; Svs7", "protein_names_uniprotkb": "Prostate and testis expressed protein 4; Calcium transport inhibitor; Caltrin; PATE-B; PATE-like protein B; SVS VII; Seminal vesicle protein 7; Seminal vesicle protein VII", "protein_names_refseq": "PATE-like protein B; SVS VII; calcium transport inhibitor; caltrin; prostate and testis expressed protein 4 precursor; prostate and testis expressed protein 4; seminal vesicle protein 7; seminal vesicle protein VII; seminal vesicle protein, secretion 7; seminal vesicle secretory protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:56872)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11118436;1400406;18387948;26731031;30452524", "class_list": "", "function": "Enhances sperm motility. Binds to calmodulin and inhibits calcium transport into spermatozoa. May modulate the function of nicotinic acetylcholine receptors., [UniProtKB, PubMed]; PATE4 is a novel factor in forming the copulatory plug that inhibits sequential matings and maintains spermatozoa in the uterus to ensure male fecundity., [RefSeq, PubMed]; Taken together, our study was the first to generate and analyze a mouse model lacking Pate4, a gene with strong expression in prostate and seminal vesicles, yet without major function for fertility., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D248;Q9R018", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0009611 response to wounding;GO:0050804 modulation of chemical synaptic transmission;GO:0099601 regulation of neurotransmitter receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q09098-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TJD7-1", "uniprot_id": [ { "id": "PDLI7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TJD7", "type": "external" } ], "mass": 50119.0, "length": 457, "protein_name": "PDZ and LIM domain protein 7", "gene_name": "Pdlim7", "organism": "Mouse", "refseq_name": "PDZ and LIM domain protein 7 isoform a", "refseq_ac": [ { "id": "NP_001107560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107560", "type": "external" } ], "gene_names_uniprotkb": "Pdlim7; Enigma", "gene_names_refseq": "LMP; Pdlim7", "protein_names_uniprotkb": "PDZ and LIM domain protein 7; LIM mineralization protein; LMP; Protein enigma", "protein_names_refseq": "LIM mineralization protein; PDZ and LIM domain protein 7 isoform a; protein enigma", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); myopathy (Disease Ontology:DOID:423)", "pathway": " (mmu:67399); (R-MMU-8853659)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10359609;20706776;21183079;21750661;30016717;30059200;30084848;32848054;32849529;34428180;34678516;35820727;36852467;39927985;40885482;9832452", "class_list": "", "function": "LMP-1 showed spatiotemporal expression patterns during molar development.[LMP-1], [RefSeq, PubMed]; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)., [UniProtKB]; PDLIM7 Synergizes With PDLIM2 and p62/Sqstm1 to Inhibit Inflammatory Signaling by Promoting Degradation of the p65 Subunit of NF-kappaB. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZY6;Q810S3;Q8C1S4;Q9CRA1", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0045669 positive regulation of osteoblast differentiation;GO:0001503 ossification", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q3TJD7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2S4-1", "uniprot_id": [ { "id": "OTUD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2S4", "type": "external" } ], "mass": 60306.0, "length": 566, "protein_name": "OTU domain-containing protein 5", "gene_name": "Otud5", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 5 isoform 3", "refseq_ac": [ { "id": "NP_001277466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277466", "type": "external" } ], "gene_names_uniprotkb": "Otud5; DXImx46e; Sfc7", "gene_names_refseq": "DUBA; DXImx46e; Otud5; Sfc7", "protein_names_uniprotkb": "OTU domain-containing protein 5; 3.4.19.12; DUBA; Deubiquitinating enzyme A", "protein_names_refseq": "OTU domain-containing protein 5 isoform 3; OTU domain-containing protein 5; deubiquinating enzyme A; deubiquitinating enzyme A", "tax_id": 10090, "disease": "", "pathway": " (mmu:54644)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10857745;20484733;21183079;21750661;21952136;22872234;25470037;25605945;30779550;32826889;34428180;38036082;38364946;38605168;38937512", "class_list": "", "function": "Data identify DUBA as a cell-intrinsic suppressor of IL-17 production, [RefSeq, PubMed]; Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis., [RefSeq, PubMed]; OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. Publication Status: Online-Only, [RefSeq, PubMed]; OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation., [RefSeq, PubMed]; Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Publication Status: Online-Only, [RefSeq, PubMed]; USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE33;Q91YL5;Q9CV50;Q9JIG6", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0032700 negative regulation of interleukin-17 production;GO:0016579 protein deubiquitination;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q3U2S4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UUQ7-1", "uniprot_id": [ { "id": "PGAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UUQ7", "type": "external" } ], "mass": 104578.0, "length": 922, "protein_name": "GPI inositol-deacylase", "gene_name": "Pgap1", "organism": "Mouse", "refseq_name": "GPI inositol-deacylase", "refseq_ac": [ { "id": "NP_001156786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156786", "type": "external" } ], "gene_names_uniprotkb": "Pgap1", "gene_names_refseq": "5033403E17Rik; 9030223K07Rik; A530084K22; D230012E17Rik; Pgap1; oto", "protein_names_uniprotkb": "GPI inositol-deacylase; 3.1.-.-; Post-GPI attachment to proteins factor 1", "protein_names_refseq": "GPI inositol-deacylase; post-GPI attachment to proteins factor 1", "tax_id": 10090, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (mmu:241062); (R-MMU-162791)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;17711852;19349973;30084848;30779550;30899004;34428180", "class_list": "glycogene", "function": "GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum (PubMed:17711852). Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein (PubMed:17711852)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 31, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E9QKG7;Q8BQ77", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0160215 deacylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007605 sensory perception of sound;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0009948 anterior/posterior axis specification;GO:0060322 head development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q3UUQ7-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UW31-1", "uniprot_id": [ { "id": "PATE2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UW31", "type": "external" } ], "mass": 13068.0, "length": 111, "protein_name": "Prostate and testis expressed protein 2", "gene_name": "Pate2", "organism": "Mouse", "refseq_name": "prostate and testis expressed protein 2 precursor", "refseq_ac": [ { "id": "NP_001028593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028593", "type": "external" } ], "gene_names_uniprotkb": "Pate2; Gm846", "gene_names_refseq": "Gm846; Pate-M; Pate2; mANLP1", "protein_names_uniprotkb": "Prostate and testis expressed protein 2; PATE-M; PATE-like protein M", "protein_names_refseq": "PATE-like protein M; prostate and testis expressed protein 2 precursor; prostate and testis expressed protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:330921)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18387948;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMN1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UW31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q50L41-1", "uniprot_id": [ { "id": "PA24F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q50L41", "type": "external" } ], "mass": 96364.0, "length": 855, "protein_name": "Cytosolic phospholipase A2 zeta", "gene_name": "Pla2g4f", "organism": "Mouse", "refseq_name": "cytosolic phospholipase A2 zeta isoform 1", "refseq_ac": [ { "id": "NP_001019316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019316", "type": "external" } ], "gene_names_uniprotkb": "Pla2g4f", "gene_names_refseq": "4732472I07Rik; Gm647; Pla2g4f; Pla2zeta", "protein_names_uniprotkb": "Cytosolic phospholipase A2 zeta; 3.1.1.4; Phospholipase A2 group IVF; cPLA2-zeta", "protein_names_refseq": "cPLA2-zeta; cytosolic phospholipase A2 zeta isoform 1; cytosolic phospholipase A2 zeta", "tax_id": 10090, "disease": "", "pathway": " (mmu:271844); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483115)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "15866882;17293613;34428180", "class_list": "", "function": "Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:15866882, PubMed:17293613). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:15866882, PubMed:17293613). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:15866882, PubMed:17293613). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQJ2;Q80VQ8;Q80VV9", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031982 vesicle;GO:0032587 ruffle membrane", "go_biological_process": "GO:0050482 arachidonate secretion;GO:0015908 fatty acid transport;GO:0046475 glycerophospholipid catabolic process;GO:0071236 cellular response to antibiotic;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q50L41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DU28-1", "uniprot_id": [ { "id": "PCX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DU28", "type": "external" } ], "mass": 234128.0, "length": 2122, "protein_name": "Pecanex-like protein 2", "gene_name": "Pcnx2", "organism": "Mouse", "refseq_name": "pecanex-like protein 2", "refseq_ac": [ { "id": "NP_780770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780770", "type": "external" } ], "gene_names_uniprotkb": "Pcnx2; Kiaa0435; Pcnxl2", "gene_names_refseq": "A830048P05; E330039K12Rik; Pcnx2; Pcnxl2; mKIAA0435", "protein_names_uniprotkb": "Pecanex-like protein 2; Pecanex homolog protein 2", "protein_names_refseq": "pecanex homolog protein 2; pecanex-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:270109)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25010494;25428506;30084848;34428180", "class_list": "", "function": "By creating new Pcnxl2 frameshift alleles using TALEN mutagenesis, we show that Pcnxl2 deficiency is responsible for mitigating the seizure phenotype - making Pcnxl2 the first known modifier gene for absence seizures in any species Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in tumorigenesis., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A2RT20;Q8BRN0;Q8C2V1;Q8CDD2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5DU28-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64338-3", "uniprot_id": [ { "id": "PDE1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64338", "type": "external" } ], "mass": 80290.0, "length": 706, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C", "gene_name": "Pde1c", "organism": "Mouse", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b", "refseq_ac": [ { "id": "NP_001020739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020739", "type": "external" } ], "gene_names_uniprotkb": "Pde1c", "gene_names_refseq": "Pde1c", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; 3.1.4.17; Cam-PDE 1C", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; cam-PDE 1C; dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 74 (Disease Ontology:DOID:0112165)", "pathway": " (mmu:18575); (R-MMU-111957)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19741056;29860631;30084848;30469494;31219806;34312235;8810348", "class_list": "", "function": "Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8810348). Exhibits high affinity for both cAMP and cGMP (By similarity). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (PubMed:19741056)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Cardiac Pde1C is a direct transcriptional target of PPARalpha. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62045;Q8BSV6", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005929 cilium;GO:0043025 neuronal cell body;GO:0005764 lysosome", "go_biological_process": "GO:0007165 signal transduction;GO:0051592 response to calcium ion;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0007608 sensory perception of smell;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64338-3", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMR0-1", "uniprot_id": [ { "id": "PCP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMR0", "type": "external" } ], "mass": 55027.0, "length": 491, "protein_name": "Lysosomal Pro-X carboxypeptidase", "gene_name": "Prcp", "organism": "Mouse", "refseq_name": "lysosomal Pro-X carboxypeptidase precursor", "refseq_ac": [ { "id": "NP_082519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082519", "type": "external" } ], "gene_names_uniprotkb": "Prcp", "gene_names_refseq": "2510048K03Rik; 2610104A14Rik; HUMPCP; PCP; Prcp", "protein_names_uniprotkb": "Lysosomal Pro-X carboxypeptidase; 3.4.16.2; PRCP; Proline carboxypeptidase; Prolylcarboxypeptidase", "protein_names_refseq": "lysosomal Pro-X carboxypeptidase precursor; lysosomal Pro-X carboxypeptidase; proline carboxypeptidase", "tax_id": 10090, "disease": "brain infarction (Disease Ontology:DOID:3454)", "pathway": " (mmu:72461); (R-MMU-6798695); (R-MMU-9970672)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;19620781;20173027;21297000;21750661;22079761;22202165;25428506;26740625;30084848;34428180", "class_list": "", "function": "Analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors, [RefSeq, PubMed]; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity)., [UniProtKB]; Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis., [RefSeq, PubMed]; PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels., [RefSeq, PubMed]; This study showed that PRCP mutant mice have a significant decrease in fat mass, although an increase in lean mass was also observed; reduced leptin levels and increased energy expenditure were also found., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLW3;Q3V302;Q8BKK3;Q8R0T8;Q9D049", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004185 serine-type carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0070008 serine-type exopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0045178 basal part of cell;GO:0005764 lysosome", "go_biological_process": "GO:0002155 regulation of thyroid hormone receptor signaling pathway;GO:0043535 regulation of blood vessel endothelial cell migration;GO:0002003 angiotensin maturation;GO:0097009 energy homeostasis;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TMR0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSK3-1", "uniprot_id": [ { "id": "PCDH8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TSK3", "type": "external" } ], "mass": 113260.0, "length": 1070, "protein_name": "Protocadherin-8", "gene_name": "Pcdh8", "organism": "Mouse", "refseq_name": "protocadherin-8 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001036191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036191", "type": "external" } ], "gene_names_uniprotkb": "Pcdh8; Papc", "gene_names_refseq": "1700080P15Rik; Papc; Pcdh8", "protein_names_uniprotkb": "Protocadherin-8; Arcadlin; Paraxial protocadherin", "protein_names_refseq": "arcadlin; paraxial protocadherin; protocadherin-8 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18530)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;17988630", "class_list": "", "function": "Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis., [UniProtKB, PubMed]; This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported. [provided by RefSeq, Sep 2009]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9577, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q05BD0;Q8C824;Q9JKP3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0016331 morphogenesis of embryonic epithelium;GO:0001756 somitogenesis;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TSK3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W65-1", "uniprot_id": [ { "id": "PCSK9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W65", "type": "external" } ], "mass": 74823.0, "length": 694, "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "Pcsk9", "organism": "Mouse", "refseq_name": "proprotein convertase subtilisin/kexin type 9 precursor", "refseq_ac": [ { "id": "NP_705793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705793", "type": "external" } ], "gene_names_uniprotkb": "Pcsk9; Narc1", "gene_names_refseq": "FH3; HCHOLA3; Narc1; PC9; Pcsk9", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 9; 3.4.21.-; NARC-1; Neural apoptosis-regulated convertase 1; PC9; Proprotein convertase 9; Subtilisin/kexin-like protease PC9", "protein_names_refseq": "NARC-1; convertase subtilisin; neural apoptosis regulated convertase 1; proprotein convertase 9; proprotein convertase PC9; proprotein convertase subtilisin/kexin type 9 precursor; subtilisin/kexin-like protease PC9", "tax_id": 10090, "disease": "familial hypercholesterolemia (Disease Ontology:DOID:13810); hypobetalipoproteinemia (Disease Ontology:DOID:1390)", "pathway": " (mmu:100102); (R-MMU-381426); (R-MMU-8866427); (R-MMU-8957275); (R-MMU-8964038)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "12552133;12897189;14622975;15178557;15358785;18498363;22481440;22580899", "class_list": "", "function": "Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways., [UniProtKB, PubMed, PubMed]; Human, mouse, and rat PCSK9 promoters contain 2 typical conserved motifs for cholesterol regulation: a sterol regulatory element (SRE) and an Sp1 site., [RefSeq, PubMed]; NARC-1 has a role in regulating both the level of LDLR and that of circulating apoB-containing lipoproteins in an LDLR-dependent and -independent fashion, [RefSeq, PubMed]; NARC-1 is a proteinase K-like subtilase with a role in the differentiation of cortical neurons, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1AZI4;Q3UEH7;Q8BXW9;Q8CFT6", "ec_number_list": [ { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.21.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.94", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0019871 sodium channel inhibitor activity;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0034185 apolipoprotein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0001889 liver development;GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0016485 protein processing;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80W65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGF7-1", "uniprot_id": [ { "id": "PAN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGF7", "type": "external" } ], "mass": 135253.0, "length": 1200, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit Pan2", "gene_name": "Pan2", "organism": "Mouse", "refseq_name": "PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2", "refseq_ac": [ { "id": "NP_001239255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239255", "type": "external" } ], "gene_names_uniprotkb": "Pan2; Kiaa0710; Usp52", "gene_names_refseq": "1200014O24Rik; Pan2; Usp52; mKIAA0710", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit Pan2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "AN2 polyA specific ribonuclease subunit homolog; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2; PAN2 polyA specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2; PAN2-PAN3 deadenylation complex catalytic subunit Pan2; inactive ubiquitin carboxyl-terminal hydrolase 52; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52", "tax_id": 10090, "disease": "", "pathway": " (mmu:103135); (R-MMU-429947)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "16284618;18625844;21078877;21183079;25428506;25428507;25605945;30084848;30779550;34428180;35820727", "class_list": "", "function": "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 (PubMed:16284618). Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation (By similarity)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZK5;Q68FH6;Q6ZQ63", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BGF7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGX1-1", "uniprot_id": [ { "id": "PED1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGX1", "type": "external" } ], "mass": 49968.0, "length": 433, "protein_name": "PC-esterase domain-containing protein 1B", "gene_name": "Pced1b", "organism": "Mouse", "refseq_name": "PC-esterase domain-containing protein 1B", "refseq_ac": [ { "id": "NP_758497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758497", "type": "external" } ], "gene_names_uniprotkb": "Pced1b; Fam113b", "gene_names_refseq": "Fam113b; Pced1b", "protein_names_uniprotkb": "PC-esterase domain-containing protein 1B; Protein FAM113B", "protein_names_refseq": "PC-esterase domain-containing protein 1B; family with sequence similarity 113, member B; protein FAM113B", "tax_id": 10090, "disease": "", "pathway": " (mmu:239647)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;32152506;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RK34", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BGX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX94-1", "uniprot_id": [ { "id": "OSBL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX94", "type": "external" } ], "mass": 55384.0, "length": 484, "protein_name": "Oxysterol-binding protein-related protein 2", "gene_name": "Osbpl2", "organism": "Mouse", "refseq_name": "oxysterol-binding protein-related protein 2", "refseq_ac": [ { "id": "NP_653083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653083", "type": "external" } ], "gene_names_uniprotkb": "Osbpl2", "gene_names_refseq": "C130070J12Rik; ORP-2; Orp2; Osbpl2", "protein_names_uniprotkb": "Oxysterol-binding protein-related protein 2; ORP-2; OSBP-related protein 2", "protein_names_refseq": "OSBP-related protein 2; oxysterol-binding protein-related protein 2", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 67 (Disease Ontology:DOID:0110588); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (mmu:228983); (R-MMU-192105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25759012;35041619;35253614;36577376", "class_list": "", "function": "Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). In conjunction with PLCB3, it may contribute to the control of keratinocyte proliferation and differentiation, probably through the regulation of the ERK pathway and the cell cycle. Involved in angiogenic signaling pathways such as VEGFR2 in endothelial cells. Controls LDL-cholesterol plasma membrane delivery, focal adhesion kinase (FAK) activation and PI(4,5)P2 generation, enhancing cell adhesion., [UniProtKB, UniProtKB]; Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling. Publication Status: Online-Only, [RefSeq, PubMed]; OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin., [RefSeq, PubMed]; The lipid transporter ORP2 regulates synaptic neurotransmitter release via two distinct mechanisms., [RefSeq, PubMed]; The regulation of OSBPL2 by Mir96 was investigated in Mir96 mutant mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TCK8;Q8R0H8", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0015485 cholesterol binding;GO:0008526 phosphatidylinositol transfer activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0051289 protein homotetramerization;GO:0015914 phospholipid transport;GO:0032367 intracellular cholesterol transport;GO:0030301 cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BX94-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ20-1", "uniprot_id": [ { "id": "PAR12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ20", "type": "external" } ], "mass": 79917.0, "length": 711, "protein_name": "Protein mono-ADP-ribosyltransferase PARP12", "gene_name": "Parp12", "organism": "Mouse", "refseq_name": "protein mono-ADP-ribosyltransferase PARP12", "refseq_ac": [ { "id": "NP_766481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766481", "type": "external" } ], "gene_names_uniprotkb": "Parp12; Zc3hdc1", "gene_names_refseq": "9930021O16; ARTD12; PARP-12; Parp12; Zc3hdc1", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP12; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 12; ARTD12; PARP-12; Poly [ADP-ribose] polymerase 12; Zinc finger CCCH domain-containing protein 1", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 12; poly ADP-ribose polymerase 12; poly [ADP-ribose] polymerase 12; protein mono-ADP-ribosyltransferase PARP12; zinc finger CCCH domain-containing protein 1; zinc finger CCCH type domain containing 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243771)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21183079;26740625;27802388;29921658;30084848;34428180;35916471;37305966;37695054", "class_list": "", "function": "Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation (PubMed:35916471). Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation., [UniProtKB, UniProtKB, PubMed]; PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner., [RefSeq, PubMed]; PARP12 regulates mouse oocyte meiotic maturation., [RefSeq, PubMed]; To screen for antiviral IFN-stimulated genes that restricted Zika virus replication, and identified PARP12 as a strong inhibitor of Zika virus replication. Findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VB94;Q80VL6;Q8K333;Q8R3U2", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005802 trans-Golgi network;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0070633 transepithelial transport;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BZ20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C669-1", "uniprot_id": [ { "id": "PELI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C669", "type": "external" } ], "mass": 46259.0, "length": 418, "protein_name": "E3 ubiquitin-protein ligase pellino homolog 1", "gene_name": "Peli1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase pellino homolog 1", "refseq_ac": [ { "id": "NP_075813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075813", "type": "external" } ], "gene_names_uniprotkb": "Peli1", "gene_names_refseq": "2810468L03Rik; A930031K15Rik; D11Ertd676e; Peli1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase pellino homolog 1; 2.3.2.27; Pellino-1; RING-type E3 ubiquitin transferase pellino homolog 1", "protein_names_refseq": "E3 ubiquitin-protein ligase pellino homolog 1; RING-type E3 ubiquitin transferase pellino homolog 1; protein pellino homolog 1", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:67245); (R-MMU-5675482); (R-MMU-9020702); (R-MMU-937039); (R-MMU-975144)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "11306823;16951688;26495903;29883609;30084848;30779550;31142803;33052227;33215753;34428180;34706239;38580196;38712476", "class_list": "", "function": "Age-Related Decrease in Pellino-1 Expression Contributes to Osteoclast-Mediated Bone Loss., [RefSeq, PubMed]; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:16951688, PubMed:29883609). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (By similarity). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (PubMed:31142803). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1. Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination. Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Pellino1 orchestrates gut-kidney axis to perpetuate septic acute kidney injury through activation of STING pathway and NLRP3 inflammasome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91YL9;Q9CV22;Q9ERJ8", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0035861 site of double-strand break", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:1904263 positive regulation of TORC1 signaling;GO:0032496 response to lipopolysaccharide;GO:0042130 negative regulation of T cell proliferation;GO:0001819 positive regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8C669-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAE9-1", "uniprot_id": [ { "id": "PDXL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAE9", "type": "external" } ], "mass": 64973.0, "length": 603, "protein_name": "Podocalyxin-like protein 2", "gene_name": "Podxl2", "organism": "Mouse", "refseq_name": "podocalyxin-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_795947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795947", "type": "external" } ], "gene_names_uniprotkb": "Podxl2", "gene_names_refseq": "D130074J02Rik; PODLX2; Podxl2", "protein_names_uniprotkb": "Podocalyxin-like protein 2; Endoglycan", "protein_names_refseq": "endoglycan; podocalyxin-like protein 2 isoform 2; podocalyxin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319655); (R-MMU-156584)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661", "class_list": "", "function": "Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFW3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050901 leukocyte tethering or rolling;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8CAE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CBQ5-1", "uniprot_id": [ { "id": "P4K2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CBQ5", "type": "external" } ], "mass": 53478.0, "length": 469, "protein_name": "Phosphatidylinositol 4-kinase type 2-beta", "gene_name": "Pi4k2b", "organism": "Mouse", "refseq_name": "phosphatidylinositol 4-kinase type 2-beta isoform 1", "refseq_ac": [ { "id": "NP_080227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080227", "type": "external" } ], "gene_names_uniprotkb": "Pi4k2b", "gene_names_refseq": "2610042N09Rik; 4933409G22Rik; Pi4k2b", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-beta; 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta", "protein_names_refseq": "phosphatidylinositol 4-kinase type 2-beta isoform 1; phosphatidylinositol 4-kinase type II-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:67073); (R-MMU-1483248); (R-MMU-1660499); (R-MMU-1660514); (R-MMU-1660516)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "12011096;16949365;19144319;21750661;26495903", "class_list": "", "function": "PI 4-kinase functions to negatively regulate GLUT4 translocation through its interaction with NCS-1., [RefSeq, PubMed]; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking., [UniProtKB, UniProtKB]; UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z30;Q9D072;Q9D471", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CBQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922R8-1", "uniprot_id": [ { "id": "PDIA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922R8", "type": "external" } ], "mass": 48100.0, "length": 440, "protein_name": "Protein disulfide-isomerase A6", "gene_name": "Pdia6", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdia6; Txndc7", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein disulfide-isomerase A6; 5.3.4.1; Thioredoxin domain-containing protein 7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:71853); (R-MMU-381426); (R-MMU-8957275)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21183079;24508390;26495903;26740625;29187734;34203471;34418053;34428180;35820727;37453647;37828378", "class_list": "", "function": "May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:24508390). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK54", "ec_number_list": [ { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0030168 platelet activation;GO:0070527 platelet aggregation;GO:0034976 response to endoplasmic reticulum stress;GO:1903895 negative regulation of IRE1-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q922R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NE9-1", "uniprot_id": [ { "id": "PBX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99NE9", "type": "external" } ], "mass": 41961.0, "length": 378, "protein_name": "Pre-B-cell leukemia transcription factor 4", "gene_name": "Pbx4", "organism": "Mouse", "refseq_name": "pre-B-cell leukemia transcription factor 4 isoform 1", "refseq_ac": [ { "id": "NP_001020125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020125", "type": "external" } ], "gene_names_uniprotkb": "Pbx4", "gene_names_refseq": "2410015M21Rik; Pbx4", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor 4; Homeobox protein PBX4", "protein_names_refseq": "homeobox protein PBX4; pre-B-cell leukemia transcription factor 4 isoform 1; pre-B-cell leukemia transcription factor 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:80720)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11335119;21750661;38230761", "class_list": "", "function": "Transcription factor PBX4 regulates limb development and haematopoiesis in mice., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFL2;Q99NE8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001741 XY body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99NE9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQZ0-1", "uniprot_id": [ { "id": "ORML2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQZ0", "type": "external" } ], "mass": 17390.0, "length": 153, "protein_name": "ORM1-like protein 2", "gene_name": "Ormdl2", "organism": "Mouse", "refseq_name": "ORM1-like protein 2", "refseq_ac": [ { "id": "NP_077142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077142", "type": "external" } ], "gene_names_uniprotkb": "Ormdl2", "gene_names_refseq": "0610012C09Rik; Ormdl2", "protein_names_uniprotkb": "ORM1-like protein 2", "protein_names_refseq": "ORM1-like protein 2", "tax_id": 10090, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:66844); (R-MMU-1660661)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "18250455;20173027;20484733;21952136;25428506;25428507;25605945;27802388;30084848;30779550;31599954;31880535;33643282;33649389;34428180;37828378", "class_list": "", "function": "ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; We attempted to generate Ormdl triple knockouts mice by crossing Ormdl 1-/- 2 +/- 3 +/- mice, no viable Ormdl1/2/3 triple knockouts mice were identified at weaning. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF72;Q9CSJ7;Q9CVL6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9CQZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CUB6-1", "uniprot_id": [ { "id": "OTUD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CUB6", "type": "external" } ], "mass": 48823.0, "length": 454, "protein_name": "OTU domain-containing protein 1", "gene_name": "Otud1", "organism": "Mouse", "refseq_name": "OTU domain-containing protein 1", "refseq_ac": [ { "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "type": "external" } ], "gene_names_uniprotkb": "Otud1", "gene_names_refseq": "4933428L19Rik; Otud1", "protein_names_uniprotkb": "OTU domain-containing protein 1; 3.4.19.12", "protein_names_refseq": "OTU domain-containing protein 1; likely ortholog of H. sapiens OTU domain containing 1 (OTUD1)", "tax_id": 10090, "disease": "", "pathway": " (mmu:71198); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "30130141;31219806;34428180;37153745;37639212;38012669;39079388", "class_list": "", "function": "Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation., [UniProtKB, UniProtKB]; OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2. Publication Status: Online-Only, [RefSeq, PubMed]; OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis., [RefSeq, PubMed]; The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury., [RefSeq, PubMed]; We report the establishment of OTUD1-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method. The generated antibodies recognize the N-terminal portion (aa. 1-290) of human and mouse OTUD1 proteins, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2ATK4", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CUB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWP9-1", "uniprot_id": [ { "id": "P23A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWP9", "type": "external" } ], "mass": 27565.0, "length": 254, "protein_name": "Proline-rich protein 23A3", "gene_name": "Prr23a3", "organism": "Mouse", "refseq_name": "proline-rich protein 23A3", "refseq_ac": [ { "id": "NP_082309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082309", "type": "external" } ], "gene_names_uniprotkb": "Prr23a3", "gene_names_refseq": "2410012M07Rik; Prr23a3", "protein_names_uniprotkb": "Proline-rich protein 23A3", "protein_names_refseq": "proline-rich protein 23A3; proline-rich protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:71979)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CWP9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0D3-1", "uniprot_id": [ { "id": "PAPD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0D3", "type": "external" } ], "mass": 65229.0, "length": 585, "protein_name": "Poly(A) RNA polymerase, mitochondrial", "gene_name": "Mtpap", "organism": "Mouse", "refseq_name": "poly(A) RNA polymerase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_080433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080433", "type": "external" } ], "gene_names_uniprotkb": "Mtpap; Papd1", "gene_names_refseq": "0610027A18Rik; Mtpap; Papd1; Tent6", "protein_names_uniprotkb": "Poly(A) RNA polymerase, mitochondrial; 2.7.7.19; PAP-associated domain-containing protein 1; PAP; Polynucleotide adenylyltransferase", "protein_names_refseq": "PAP associated domain containing 1; PAP-associated domain-containing protein 1; poly(A) RNA polymerase, mitochondrial isoform 1 precursor; poly(A) RNA polymerase, mitochondrial; polynucleotide adenylyltransferase", "tax_id": 10090, "disease": "spastic ataxia 4 (Disease Ontology:DOID:0050943)", "pathway": " (mmu:67440)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;37507081", "class_list": "", "function": "Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UXJ1;Q8C651", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0000965 mitochondrial RNA 3'-end processing;GO:0097222 mitochondrial mRNA polyadenylation;GO:0071044 histone mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D0D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9N8-1", "uniprot_id": [ { "id": "PADC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9N8", "type": "external" } ], "mass": 21085.0, "length": 188, "protein_name": "Protease-associated domain-containing protein 1", "gene_name": "Pradc1", "organism": "Mouse", "refseq_name": "protease-associated domain-containing protein 1 isoform b precursor", "refseq_ac": [ { "id": "NP_001156899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156899", "type": "external" } ], "gene_names_uniprotkb": "Pradc1; Pap21", "gene_names_refseq": "1700040I03Rik; Pap21; Pradc1", "protein_names_uniprotkb": "Protease-associated domain-containing protein 1; Protease-associated domain-containing protein of 21 kDa", "protein_names_refseq": "protease-associated domain-containing protein 1 isoform b precursor; protease-associated domain-containing protein 1; protease-associated domain-containing protein of 21 kDa", "tax_id": 10090, "disease": "", "pathway": " (mmu:73327)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31689374", "class_list": "", "function": "PRADC1-deficient mice have reduced adiposity and enhanced locomotor activity uncoupled from metabolic health., [RefSeq, PubMed]; Plays a role in the modulation of physical activity and adiposity., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9N8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCC4-1", "uniprot_id": [ { "id": "P5CR3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCC4", "type": "external" } ], "mass": 28721.0, "length": 274, "protein_name": "Pyrroline-5-carboxylate reductase 3", "gene_name": "Pycr3", "organism": "Mouse", "refseq_name": "pyrroline-5-carboxylate reductase 3", "refseq_ac": [ { "id": "NP_079688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079688", "type": "external" } ], "gene_names_uniprotkb": "Pycr3; Pycrl", "gene_names_refseq": "1110058B13Rik; 2700073G24Rik; Pycr3; Pycrl", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 3; 1.5.1.2; P5C reductase 3; P5CR 3; Pyrroline-5-carboxylate reductase-like protein", "protein_names_refseq": "P5C reductase 3; P5CR 3; pyrroline-5-carboxylate reductase 3; pyrroline-5-carboxylate reductase-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66194); (R-MMU-8964539)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16479539;22872234;31219806;34203471;34428180;36210013", "class_list": "", "function": "Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0P9;Q9D0X2", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0004126 cytidine deaminase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0072686 mitotic spindle", "go_biological_process": "GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9DCC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK42-1", "uniprot_id": [ { "id": "PDK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK42", "type": "external" } ], "mass": 46041.0, "length": 407, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial", "gene_name": "Pdk2", "organism": "Mouse", "refseq_name": "pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1", "refseq_ac": [ { "id": "NP_598428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598428", "type": "external" } ], "gene_names_uniprotkb": "Pdk2", "gene_names_refseq": "Pdk2", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; 2.7.11.2; PDH kinase 2; Pyruvate dehydrogenase kinase isoform 2", "protein_names_refseq": "PDH kinase 2; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase 2; pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1; pyruvate dehydrogenase kinase, isozyme 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:18604); (R-MMU-204174); (R-MMU-5362517)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16631612;17669420;19147752;21190881;21411764;22360721;36288343", "class_list": "", "function": "Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:22360721). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis., [UniProtKB, PubMed]; Mitochondrial ND2 mutation contributes to HIF1alpha accumulation via increased ROS production, up-regulation of PDK2, attenuating PDH activity, thereby increasing pyruvate, resulting in HIF1alpha stabilization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC63", "ec_number_list": [ { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0010565 regulation of ketone metabolic process;GO:0006468 protein phosphorylation;GO:0010906 regulation of glucose metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JK42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG99-1", "uniprot_id": [ { "id": "PKNX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG99", "type": "external" } ], "mass": 52331.0, "length": 474, "protein_name": "Homeobox protein PKNOX2", "gene_name": "Pknox2", "organism": "Mouse", "refseq_name": "homeobox protein PKNOX2 isoform 1", "refseq_ac": [ { "id": "NP_001025009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025009", "type": "external" } ], "gene_names_uniprotkb": "Pknox2; Prep2", "gene_names_refseq": "D230005H23Rik; Pknox2; Prep2", "protein_names_uniprotkb": "Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2", "protein_names_refseq": "PBX/knotted homeobox 2; homeobox protein PKNOX2 isoform 1; homeobox protein PKNOX2; homeobox protein PREP-2; homeodomain containing transcription factor PREP2", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (mmu:208076)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12412021;15339927;21750661;25428506;30084848;34311199;37247388;38644381", "class_list": "", "function": "Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea., [RefSeq, PubMed]; PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis., [RefSeq, PubMed]; Prep2 functions to varying degrees in a broad array of tissues and developmental processes., [RefSeq, PubMed]; Transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4B0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003785 actin monomer binding;GO:0051015 actin filament binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8BG99-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8C8-1", "uniprot_id": [ { "id": "PPR35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8C8", "type": "external" } ], "mass": 28355.0, "length": 260, "protein_name": "Protein phosphatase 1 regulatory subunit 35", "gene_name": "Ppp1r35", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 35 isoform 1", "refseq_ac": [ { "id": "NP_081518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081518", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r35", "gene_names_refseq": "2010007H12Rik; 2010011D20Rik; Ppp1r35", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 35", "protein_names_refseq": "UPF0683 protein C7orf47 homolog; protein phosphatase 1 regulatory subunit 35 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69871)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16926269;21183079;21750661;25428506;32628936;34428180", "class_list": "", "function": "During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with TTTN, leading to the centriole to centrosome conversion (By similarity). In addition may play a role in the primary cilia assembly (PubMed:32628936)., [UniProtKB, UniProtKB, PubMed]; Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0045724 positive regulation of cilium assembly;GO:1903724 positive regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQT5-1", "uniprot_id": [ { "id": "POMP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQT5", "type": "external" } ], "mass": 15766.0, "length": 141, "protein_name": "Proteasome maturation protein", "gene_name": "Pomp", "organism": "Mouse", "refseq_name": "proteasome maturation protein", "refseq_ac": [ { "id": "NP_079900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079900", "type": "external" } ], "gene_names_uniprotkb": "Pomp", "gene_names_refseq": "2510048O06Rik; Pomp; Ump1", "protein_names_uniprotkb": "Proteasome maturation protein; Proteassemblin; Protein UMP1 homolog; mUMP1", "protein_names_refseq": "proteasome maturation protein; proteassemblin; protein UMP1 homolog", "tax_id": 10090, "disease": "proteosome-associated autoinflammatory syndrome 2 (Disease Ontology:DOID:0060914)", "pathway": " (mmu:66537); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10891394;10973495;21750661;25428506;25605945;30084848;31219806;31599954;34428180;35820727", "class_list": "", "function": "Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXV8;Q9CZL7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CQT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKL1-1", "uniprot_id": [ { "id": "PKR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKL1", "type": "external" } ], "mass": 44597.0, "length": 393, "protein_name": "Prokineticin receptor 1", "gene_name": "Prokr1", "organism": "Mouse", "refseq_name": "prokineticin receptor 1", "refseq_ac": [ { "id": "NP_067356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067356", "type": "external" } ], "gene_names_uniprotkb": "Prokr1; Gpr73; Pkr1", "gene_names_refseq": "EG-VEGFR1; Gpr73; Pk-r1; Pkr1; Prokr1", "protein_names_uniprotkb": "Prokineticin receptor 1; G protein-coupled receptor 73; PK-R1", "protein_names_refseq": "G-protein coupled receptor 73; prokineticin receptor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:58182); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10760605;12024206;21750661;30084848;30779550;34314870", "class_list": "", "function": "PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts., [RefSeq, PubMed]; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0M4;Q6PD11", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0032870 cellular response to hormone stimulus;GO:0007623 circadian rhythm;GO:0060976 coronary vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BS03-1", "uniprot_id": [ { "id": "PI15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BS03", "type": "external" } ], "mass": 29151.0, "length": 258, "protein_name": "Peptidase inhibitor 15", "gene_name": "Pi15", "organism": "Mouse", "refseq_name": "peptidase inhibitor 15 precursor", "refseq_ac": [ { "id": "NP_444421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444421", "type": "external" } ], "gene_names_uniprotkb": "Pi15", "gene_names_refseq": "P24TI; P25TI; PI-15; Pi15; SugarCrisp", "protein_names_uniprotkb": "Peptidase inhibitor 15; PI-15; SugarCrisp", "protein_names_refseq": "cysteine-rich secreted protein; peptidase inhibitor 15 precursor; protease inhibitor 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:94227)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11287197;21750661", "class_list": "", "function": "Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity). May play a role in facial patterning during embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN14;Q99MM7", "ec_number_list": [], "go_molecular_function": "GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BS03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBU9-1", "uniprot_id": [ { "id": "PLPP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VBU9", "type": "external" } ], "mass": 30444.0, "length": 271, "protein_name": "Phospholipid phosphatase 4", "gene_name": "Plpp4", "organism": "Mouse", "refseq_name": "phospholipid phosphatase 4 isoform 1", "refseq_ac": [ { "id": "NP_001074432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074432", "type": "external" } ], "gene_names_uniprotkb": "Plpp4", "gene_names_refseq": "C030048B12Rik; Gm1090; Plpp4; Ppapdc1a", "protein_names_uniprotkb": "Phospholipid phosphatase 4; 3.1.3.4; 3.6.1.75", "protein_names_refseq": "phosphatidate phosphatase PPAPDC1A; phosphatidic acid phosphatase type 2 domain containing 1A; phosphatidic acid phosphatase type 2 domain-containing protein 1A; phospholipid phosphatase 4 isoform 1", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (mmu:381925); (R-MMU-2029485)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008195 phosphatidate phosphatase activity;GO:0000810 diacylglycerol diphosphate phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0006644 phospholipid metabolic process;GO:0001835 blastocyst hatching;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VBU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCU2-1", "uniprot_id": [ { "id": "PLLP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCU2", "type": "external" } ], "mass": 19801.0, "length": 182, "protein_name": "Plasmolipin", "gene_name": "Pllp", "organism": "Mouse", "refseq_name": "plasmolipin", "refseq_ac": [ { "id": "NP_080661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080661", "type": "external" } ], "gene_names_uniprotkb": "Pllp; Plapi; Pmlp; Tm4sf11", "gene_names_refseq": "0610010I06Rik; Plapi; Pllp; Tm4sf11", "protein_names_uniprotkb": "Plasmolipin; Plasma membrane proteolipid", "protein_names_refseq": "plasmolipin; transmembrane 4 superfamily member 11", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:67801)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11707781;18463156;21750661;25706235;26002055", "class_list": "", "function": "Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (By similarity). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mouse PLLP also functioned well as a receptor for McERV but was simply not expressed in the mouse cell types that we originally tested., [RefSeq, PubMed]; PLLP recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544Q5", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030100 regulation of endocytosis;GO:0042552 myelination;GO:0032288 myelin assembly;GO:1904298 regulation of transcytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9DCU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49764-1", "uniprot_id": [ { "id": "PLGF_MOUSE", "url": "https://www.uniprot.org/uniprot/P49764", "type": "external" } ], "mass": 17876.0, "length": 158, "protein_name": "Placenta growth factor", "gene_name": "Pgf", "organism": "Mouse", "refseq_name": "placenta growth factor isoform 1 precursor", "refseq_ac": [ { "id": "NP_032853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032853", "type": "external" } ], "gene_names_uniprotkb": "Pgf; Plgf", "gene_names_refseq": "PIGF; Pgf; Plgf", "protein_names_uniprotkb": "Placenta growth factor; PlGF", "protein_names_refseq": "placenta growth factor isoform 1 precursor; placenta growth factor", "tax_id": 10090, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); pyelonephritis (Disease Ontology:DOID:11400); limited scleroderma (Disease Ontology:DOID:1577); breast cancer (Disease Ontology:DOID:1612); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); carotid artery disease (Disease Ontology:DOID:3407); renal cell carcinoma (Disease Ontology:DOID:4450); lymphedema (Disease Ontology:DOID:4977); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18654); (R-MMU-194313); (R-MMU-195399)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;8903720;9401819", "class_list": "", "function": "Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0001666 response to hypoxia;GO:0005977 glycogen metabolic process;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49764-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D711-1", "uniprot_id": [ { "id": "PIR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D711", "type": "external" } ], "mass": 32066.0, "length": 290, "protein_name": "Pirin", "gene_name": "Pir", "organism": "Mouse", "refseq_name": "pirin isoform 1", "refseq_ac": [ { "id": "NP_081429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081429", "type": "external" } ], "gene_names_uniprotkb": "Pir", "gene_names_refseq": "2310042L19Rik; Pirnl; Pir", "protein_names_uniprotkb": "Pirin; 1.13.11.24; Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase", "protein_names_refseq": "iron-binding nuclear protein; pirin isoform 1; pirin like; probable quercetin 2,3-dioxygenase PIR; probable quercetinase", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:69656); (R-MMU-8935690)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "19372376;20010624;21750661;21801495;25428506;30084848;30779550;34428180;38148593;38749744", "class_list": "", "function": "Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~38%., [RefSeq, PubMed]; PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-kappaB Axis., [RefSeq, PubMed]; Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival., [RefSeq, PubMed]; Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain., [RefSeq, PubMed]; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AIH9;Q3UAN0;Q8CIE9", "ec_number_list": [ { "id": "1.13.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.24", "type": "external" } ], "go_molecular_function": "GO:0008127 quercetin 2,3-dioxygenase activity;GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030224 monocyte differentiation;GO:0030099 myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9D711-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K045-1", "uniprot_id": [ { "id": "PKN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K045", "type": "external" } ], "mass": 97881.0, "length": 878, "protein_name": "Serine/threonine-protein kinase N3", "gene_name": "Pkn3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase N3", "refseq_ac": [ { "id": "NP_722500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722500", "type": "external" } ], "gene_names_uniprotkb": "Pkn3; Pknbeta", "gene_names_refseq": "Pkn3", "protein_names_uniprotkb": "Serine/threonine-protein kinase N3; 2.7.11.13; Protein kinase PKN-beta; Protein-kinase C-related kinase 3", "protein_names_refseq": "protein kinase PKN-beta; protein kinase PKNbeta; protein-kinase C-related kinase 3; serine/threonine-protein kinase N3", "tax_id": 10090, "disease": "", "pathway": " (mmu:263803); (R-MMU-5625740); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "15282551;21750661;22217540;26742562;28851822;30084848;30422386;34428180", "class_list": "", "function": "A novel interaction of p130Cas with Ser/Thr kinase PKN3, is reported., [RefSeq, PubMed]; Contributes to invasiveness in malignant prostate cancer., [UniProtKB, PubMed]; Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers., [RefSeq, PubMed]; PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice. Publication Status: Online-Only, [RefSeq, PubMed]; PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase, [RefSeq, PubMed]; Pkn3 promotes bone resorption downstream of Wnt5a-Ror2-Rho signaling, and this pathway may be a therapeutic target for bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0035556 intracellular signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K045-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WB4-1", "uniprot_id": [ { "id": "PKHF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WB4", "type": "external" } ], "mass": 27755.0, "length": 249, "protein_name": "Pleckstrin homology domain-containing family F member 2", "gene_name": "Plekhf2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family F member 2", "refseq_ac": [ { "id": "NP_780384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780384", "type": "external" } ], "gene_names_uniprotkb": "Plekhf2", "gene_names_refseq": "1110070J07Rik; Plekhf2; ZFYVE18", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 2; PH domain-containing family F member 2", "protein_names_refseq": "PH domain-containing family F member 2; pleckstrin homology domain-containing family F member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71801)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18288467;19144319;21183079;21750661;24416124", "class_list": "", "function": "May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF-induced apoptosis., [UniProtKB, PubMed]; Results demonstrate that EAPF/Phafin-2 facilitates TNF-alpha-induced cellular apoptosis through an ER-mitochondrial apoptotic pathway., [RefSeq, PubMed]; These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0031901 early endosome membrane;GO:0030133 transport vesicle;GO:0012505 endomembrane system", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91WB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YTS9-1", "uniprot_id": [ { "id": "PPAT_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YTS9", "type": "external" } ], "mass": 46405.0, "length": 425, "protein_name": "Testicular acid phosphatase", "gene_name": "Acp4", "organism": "Mouse", "refseq_name": "testicular acid phosphatase isoform 1 precursor", "refseq_ac": [ { "id": "NP_001181963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181963", "type": "external" } ], "gene_names_uniprotkb": "Acp4; Acpt", "gene_names_refseq": "Acp4; Acpt; EG546967; Gm1432", "protein_names_uniprotkb": "Testicular acid phosphatase; 3.1.3.48; Acid phosphatase 4", "protein_names_refseq": "acid phosphatase, testicular; testicular acid phosphatase isoform 1 precursor; testicular acid phosphatase", "tax_id": 10090, "disease": "amelogenesis imperfecta type 1J (Disease Ontology:DOID:0080953)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "21750661;25428506;26547858;27843125;36183038", "class_list": "", "function": "ACPT inhibits cell proliferation through beta-catenin-mediated signaling in dental mesenchyme but elicits odontoblast differentiation and mineralization by supplying phosphate during dentin formation., [RefSeq, PubMed]; Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations. Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine phosphatase that dephosphorylates the receptor tyrosine-protein kinase ERBB4, thereby inhibiting its ligand-induced proteolytic cleavage (By similarity). Involved in odontogenesis (PubMed:27843125). Regulates odontoblast cell fate via its extracellular catalytic domain by inhibiting proliferation and promoting differentiation (PubMed:26547858)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0030971 receptor tyrosine kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045211 postsynaptic membrane;GO:0005764 lysosome;GO:0097060 synaptic membrane", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042476 odontogenesis;GO:0048168 regulation of neuronal synaptic plasticity;GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:0010955 negative regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3YTS9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWV6-1", "uniprot_id": [ { "id": "PKRI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWV6", "type": "external" } ], "mass": 21492.0, "length": 186, "protein_name": "PRKR-interacting protein 1", "gene_name": "Prkrip1", "organism": "Mouse", "refseq_name": "PRKR-interacting protein 1", "refseq_ac": [ { "id": "NP_080050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080050", "type": "external" } ], "gene_names_uniprotkb": "Prkrip1", "gene_names_refseq": "8430424D23Rik; C114; Prkrip1", "protein_names_uniprotkb": "PRKR-interacting protein 1; Protein C114", "protein_names_refseq": "PRKR-interacting protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66801); (R-MMU-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12679338;21183621;21750661", "class_list": "", "function": "C114 binds to protein kinase R (PKR), via dsRNA-binding domains of PKR and the N-terminal region of the C114 protein, [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity., [UniProtKB, PubMed, UniProtKB]; Significant elevations in the titer of novel auto-Ab were noted against angiotensinogen and PRKRIP1 in renal insufficiency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL85;Q9CXA5;Q9CY32", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0006469 negative regulation of protein kinase activity;GO:0008380 RNA splicing;GO:0003014 renal system process;GO:0042326 negative regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CWV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5K2P8-1", "uniprot_id": [ { "id": "POLS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5K2P8", "type": "external" } ], "mass": 91852.0, "length": 849, "protein_name": "Polyserase-2", "gene_name": "Prss36", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prss36", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyserase-2; 3.4.21.-; Polyserine protease 2; Serine protease 36", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:77613)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15536082;21750661;31219806", "class_list": "", "function": "Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1., [UniProtKB, UniProtKB, UniProtKB]; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 6, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5K2P8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0K9-1", "uniprot_id": [ { "id": "PLSI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0K9", "type": "external" } ], "mass": 70408.0, "length": 630, "protein_name": "Plastin-1", "gene_name": "Pls1", "organism": "Mouse", "refseq_name": "plastin-1", "refseq_ac": [ { "id": "NP_001028382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028382", "type": "external" } ], "gene_names_uniprotkb": "Pls1", "gene_names_refseq": "Pls1", "protein_names_uniprotkb": "Plastin-1", "protein_names_refseq": "I-fimbrin; plastin 1, I; plastin-1", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 76 (Disease Ontology:DOID:0112167); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (mmu:102502)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19321664;21750661;25124451;27614263;27811163;34203471", "class_list": "", "function": "Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions (PubMed:27811163)., [UniProtKB, PubMed, PubMed]; PLS1 biases actin toward liquid packing, which allows stereocilia to grow to a greater diameter., [RefSeq, PubMed]; Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network., [RefSeq, PubMed]; Results show that plastin 1 is dispensable for the initial formation of stereocilia., [RefSeq, PubMed]; We have identified a role for L-plastin in stabilizing long-lived podosomes and in enabling macrophage motility, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0001951 intestinal D-glucose absorption;GO:1902896 terminal web assembly;GO:0051017 actin filament bundle assembly;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0051639 actin filament network formation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3V0K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZD7-1", "uniprot_id": [ { "id": "PLK5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4FZD7", "type": "external" } ], "mass": 66055.0, "length": 595, "protein_name": "Inactive serine/threonine-protein kinase PLK5", "gene_name": "Plk5", "organism": "Mouse", "refseq_name": "inactive serine/threonine-protein kinase PLK5 isoform 2", "refseq_ac": [ { "id": "NP_001334053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334053", "type": "external" } ], "gene_names_uniprotkb": "Plk5", "gene_names_refseq": "6330514A18Rik; Plk5", "protein_names_uniprotkb": "Inactive serine/threonine-protein kinase PLK5; PLK-5; Polo-like kinase 5", "protein_names_refseq": "inactive serine/threonine-protein kinase PLK5 isoform 2; inactive serine/threonine-protein kinase PLK5; serine/threonine-protein kinase PLK5", "tax_id": 10090, "disease": "", "pathway": " (mmu:216166)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20100802;21245385;21750661;25428506", "class_list": "", "function": "DNA and protein sequence analyses show that Plk5 shares more similarities with Plk2 and Plk3 than with Plk1 and Plk4., [RefSeq, PubMed]; Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation., [UniProtKB, PubMed, PubMed]; Plk5 is mostly expressed in the brain of both mice and humans, and it modulates the formation of neuritic processes upon stimulation of the brain-derived neurotrophic factor (BDNF)/nerve growth factor (NGF)-Ras pathway in neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGS4;Q8C096", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4FZD7-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLJ3-1", "uniprot_id": [ { "id": "PLCX3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLJ3", "type": "external" } ], "mass": 36314.0, "length": 321, "protein_name": "PI-PLC X domain-containing protein 3", "gene_name": "Plcxd3", "organism": "Mouse", "refseq_name": "PI-PLC X domain-containing protein 3", "refseq_ac": [ { "id": "NP_796329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796329", "type": "external" } ], "gene_names_uniprotkb": "Plcxd3", "gene_names_refseq": "B130016O10Rik; Plcxd3", "protein_names_uniprotkb": "PI-PLC X domain-containing protein 3", "protein_names_refseq": "PI-PLC X domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:239318)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22732399;24028506;24692514;34428180", "class_list": "", "function": "Plcxd3 is an activity dependent gene in mouse olfactory sensory neurons., [RefSeq, PubMed]; Three intronic SNPs in the PLCXD3 gene (rs319013, rs76547469, and rs545358) are associated with increased risk of CJD compared with published healthy control data and represent the first major association of a non- PRNP candidate gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BYR3", "ec_number_list": [], "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BLJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRJ4-1", "uniprot_id": [ { "id": "PPR3E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRJ4", "type": "external" } ], "mass": 30575.0, "length": 279, "protein_name": "Protein phosphatase 1 regulatory subunit 3E", "gene_name": "Ppp1r3e", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppp1r3e", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3E", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:105651)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15752363;21183079;21750661", "class_list": "", "function": "Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding;GO:0050196 [phosphorylase] phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BRJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97813-1", "uniprot_id": [ { "id": "PLD2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97813", "type": "external" } ], "mass": 106168.0, "length": 933, "protein_name": "Phospholipase D2", "gene_name": "Pld2", "organism": "Mouse", "refseq_name": "phospholipase D2 isoform 2", "refseq_ac": [ { "id": "NP_032902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032902", "type": "external" } ], "gene_names_uniprotkb": "Pld2", "gene_names_refseq": "PLD1C; Pld2", "protein_names_uniprotkb": "Phospholipase D2; 3.1.4.4; Choline phosphatase 2; PLD 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2; mPLD2", "protein_names_refseq": "choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D2 isoform 2", "tax_id": 10090, "disease": "developmental cardiac valvular defect (Disease Ontology:DOID:0080633); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (mmu:18806); (R-MMU-1483166); (R-MMU-2029485); (R-MMU-9013149); (R-MMU-9013404)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "20647543;21085684;21750661;30084848;31219806;33368247;34428180;36700766;38703555;9307024;9395408;9560313;9837959", "class_list": "", "function": "Function as phospholipase selective for phosphatidylcholine (PubMed:21085684). May have a role in signal-induced cytoskeletal regulation and/or endocytosis (PubMed:9395408)., [UniProtKB, PubMed, PubMed]; PLD2 deficiency alleviates endothelial glycocalyx degradation in LPS-induced ARDS/ALI., [RefSeq, PubMed]; PLD2 deletion alleviates disruption of tight junctions in sepsis-induced ALI by regulating PA/STAT3 phosphorylation pathway., [RefSeq, PubMed]; This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0005080 protein kinase C binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0005901 caveola", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0035556 intracellular signal transduction;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97813-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35385-1", "uniprot_id": [ { "id": "PPE2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35385", "type": "external" } ], "mass": 86645.0, "length": 757, "protein_name": "Serine/threonine-protein phosphatase with EF-hands 2", "gene_name": "Ppef2", "organism": "Mouse", "refseq_name": "serine/threonine-protein phosphatase with EF-hands 2", "refseq_ac": [ { "id": "NP_035278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035278", "type": "external" } ], "gene_names_uniprotkb": "Ppef2", "gene_names_refseq": "Ppef2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase with EF-hands 2; 3.1.3.16; PPEF-2", "protein_names_refseq": "serine/threonine-protein phosphatase with EF-hands 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19023)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "29187734;30809231;38157933;40021952;9326663", "class_list": "", "function": "Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission., [UniProtKB]; The m[6]A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0050906 detection of stimulus involved in sensory perception;GO:0007601 visual perception;GO:0070301 cellular response to hydrogen peroxide;GO:0043409 negative regulation of MAPK cascade;GO:2001234 negative regulation of apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35385-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06803-1", "uniprot_id": [ { "id": "PIM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P06803", "type": "external" } ], "mass": 35451.0, "length": 313, "protein_name": "Serine/threonine-protein kinase pim-1", "gene_name": "Pim1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase pim-1 isoform 1", "refseq_ac": [ { "id": "NP_032868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032868", "type": "external" } ], "gene_names_uniprotkb": "Pim1; Pim-1", "gene_names_refseq": "Pim-1; Pim1", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-1; 2.7.11.1", "protein_names_refseq": "proto-oncogene serine/threonine-protein kinase pim-1; proviral integration site 1; serine/threonine-protein kinase pim-1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:18712)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10931201;15199164;15280015;1825810;18438430;19687226;21750661;27923061;3015420;31548394;38735366;38940430;7689870;8228813", "class_list": "", "function": "NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation., [RefSeq, PubMed]; PIM1 alleviated liver oxidative stress and NAFLD by regulating the NRF2/HO-1/NQO1 pathway., [RefSeq, PubMed]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15199164, PubMed:1825810). Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) (By similarity). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity (PubMed:18438430). The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis (PubMed:18438430). Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1 (PubMed:15280015). Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis (By similarity). Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C (By similarity). Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability (By similarity). Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels (By similarity). Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation (By similarity). May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Also acts as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (PubMed:19687226). Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex (PubMed:31548394). Acts as a negative regulator of innate immunity by mediating phosphorylation and inactivation of GBP1 in absence of infection: phosphorylation of GBP1 induces interaction with 14-3-3 protein sigma (SFN) and retention in the cytosol (By similarity). Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (By similarity). Promotes brown adipocyte differentiation (PubMed:27923061)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6XDQ5;Q8CFN8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0043024 ribosomal small subunit binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0070561 vitamin D receptor signaling pathway;GO:1905062 positive regulation of cardioblast proliferation;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P06803-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15974-1", "uniprot_id": [ { "id": "PHXR4_MOUSE", "url": "https://www.uniprot.org/uniprot/P15974", "type": "external" } ], "mass": 10493.0, "length": 95, "protein_name": "Putative per-hexamer repeat protein 4", "gene_name": "Phxr4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phxr4", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative per-hexamer repeat protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3267239", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15974-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40935-1", "uniprot_id": [ { "id": "PNMT_MOUSE", "url": "https://www.uniprot.org/uniprot/P40935", "type": "external" } ], "mass": 32544.0, "length": 295, "protein_name": "Phenylethanolamine N-methyltransferase", "gene_name": "Pnmt", "organism": "Mouse", "refseq_name": "phenylethanolamine N-methyltransferase", "refseq_ac": [ { "id": "NP_032916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032916", "type": "external" } ], "gene_names_uniprotkb": "Pnmt", "gene_names_refseq": "Pent; Pnmt", "protein_names_uniprotkb": "Phenylethanolamine N-methyltransferase; 2.1.1.28; Noradrenaline N-methyltransferase; PNMTase", "protein_names_refseq": "PNMTase; noradrenaline N-methyltransferase; phenylethanolamine N-methyltransferase", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (mmu:18948); (R-MMU-209905)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1320721;17698731;8000434", "class_list": "", "function": "Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:17698731). Other substrates include phenylethanolamine, octopamine and normetanephrine (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.28", "type": "external" } ], "go_molecular_function": "GO:0004603 phenylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0042415 norepinephrine metabolic process;GO:0032259 methylation;GO:0042418 epinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P40935-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46471-1", "uniprot_id": [ { "id": "PRS7_MOUSE", "url": "https://www.uniprot.org/uniprot/P46471", "type": "external" } ], "mass": 48648.0, "length": 433, "protein_name": "26S proteasome regulatory subunit 7", "gene_name": "Psmc2", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 7", "refseq_ac": [ { "id": "NP_001355590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355590", "type": "external" } ], "gene_names_uniprotkb": "Psmc2; Mss1", "gene_names_refseq": "Psmc2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2", "protein_names_refseq": "26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; proteasome 26S subunit ATPase 2", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:19181); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16857966;22078707;26495903;33625534;34428180;35820727;36288343;37507081;37828378;39627609;40684658;8247131;9353061", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]; Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08531;Q3TGX5;Q9DBA1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0140296 general transcription initiation factor binding;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P46471-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54279-1", "uniprot_id": [ { "id": "PMS2_MOUSE", "url": "https://www.uniprot.org/uniprot/P54279", "type": "external" } ], "mass": 95298.0, "length": 859, "protein_name": "Mismatch repair endonuclease PMS2", "gene_name": "Pms2", "organism": "Mouse", "refseq_name": "mismatch repair endonuclease PMS2", "refseq_ac": [ { "id": "NP_032912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032912", "type": "external" } ], "gene_names_uniprotkb": "Pms2", "gene_names_refseq": "Pms2; Pmsl2", "protein_names_uniprotkb": "Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2", "protein_names_refseq": "DNA mismatch repair protein PMS2; PMS1 protein homolog 2; mismatch repair endonuclease PMS2; postmeiotic segregation increased 2", "tax_id": 10090, "disease": "hereditary nonpolyposis colorectal cancer type 4 (Disease Ontology:DOID:0070275); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (mmu:18861); (R-MMU-5358565)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;28283534;34887587;36952545;7628019", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity)., [UniProtKB, UniProtKB]; Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity. Publication Status: Online-Only, [RefSeq, PubMed]; Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ22", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004519 endonuclease activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032389 MutLalpha complex;GO:0032300 mismatch repair complex", "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0006298 mismatch repair;GO:0016446 somatic hypermutation of immunoglobulin genes", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P54279-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62515-1", "uniprot_id": [ { "id": "PO3F4_MOUSE", "url": "https://www.uniprot.org/uniprot/P62515", "type": "external" } ], "mass": 39417.0, "length": 361, "protein_name": "POU domain, class 3, transcription factor 4", "gene_name": "Pou3f4", "organism": "Mouse", "refseq_name": "POU domain, class 3, transcription factor 4", "refseq_ac": [ { "id": "NP_032927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032927", "type": "external" } ], "gene_names_uniprotkb": "Pou3f4; Brn-4; Brn4; Otf9", "gene_names_refseq": "Brn-4; Brn4; OTF-9; Otf9; Pou3f4; Slf; oct-9", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 4; Brain-4; Brain-specific homeobox/POU domain protein 4; Brn-4; OTF-9; Oct-9; Octamer-binding protein 9; Octamer-binding transcription factor 9", "protein_names_refseq": "POU domain, class 3, transcription factor 4; brain-4 class III POU-domain protein; brain-specific homeobox/POU domain protein 4; octamer-binding protein 9; octamer-binding transcription factor 9; sex linked fidget", "tax_id": 10090, "disease": "X-linked deafness 2 (Disease Ontology:DOID:0111737)", "pathway": " (mmu:18994)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1565620;25428506;38577978", "class_list": "", "function": "Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain., [UniProtKB]; Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25216", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007605 sensory perception of sound;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62515-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70208-1", "uniprot_id": [ { "id": "PLXA3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70208", "type": "external" } ], "mass": 207958.0, "length": 1872, "protein_name": "Plexin-A3", "gene_name": "Plxna3", "organism": "Mouse", "refseq_name": "plexin-A3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_032909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032909", "type": "external" } ], "gene_names_uniprotkb": "Plxna3", "gene_names_refseq": "PlexA3; Plxa3; Plxn3; Plxn4; Plxna3; SEX; mKIAA4078", "protein_names_uniprotkb": "Plexin-A3", "protein_names_refseq": "plexin 3; plexin-A3 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18846); (R-MMU-399954); (R-MMU-399955); (R-MMU-399956)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11683995;18262512;18804103;19020035;19717441;20010807;30899004;31219806;33300544;34203471;34428180;8806646", "class_list": "", "function": "Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A5D6Q5;Q684J0;Q8BWZ5", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0051495 positive regulation of cytoskeleton organization;GO:0071526 semaphorin-plexin signaling pathway;GO:0021766 hippocampus development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P70208-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97819-1", "uniprot_id": [ { "id": "PLPL9_MOUSE", "url": "https://www.uniprot.org/uniprot/P97819", "type": "external" } ], "mass": 89560.0, "length": 807, "protein_name": "85/88 kDa calcium-independent phospholipase A2", "gene_name": "Pla2g6", "organism": "Mouse", "refseq_name": "85/88 kDa calcium-independent phospholipase A2 isoform 2", "refseq_ac": [ { "id": "NP_001185952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185952", "type": "external" } ], "gene_names_uniprotkb": "Pla2g6; Pnpla9", "gene_names_refseq": "PNPLA9; Pla2g6; iPLA(2)beta; iPLA2beta; iPLA2", "protein_names_uniprotkb": "85/88 kDa calcium-independent phospholipase A2; 2-lysophosphatidylcholine acylhydrolase; 3.1.1.4; 3.1.1.5; 3.1.2.2; CaI-PLA2; GVI PLA2; Group VI phospholipase A2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; PNPLA9; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; iPLA2-beta", "protein_names_refseq": "2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2 isoform 2; 85/88 kDa calcium-independent phospholipase A2; GVI PLA2; caI-PLA2; group VI phospholipase A2; iPLA2-beta; intracellular membrane-associated calcium-independent phospholipase A2 beta; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9", "tax_id": 10090, "disease": "Parkinson's disease 14 (Disease Ontology:DOID:0060900); dystonia 12 (Disease Ontology:DOID:0090056); neurodegeneration with brain iron accumulation 2a (Disease Ontology:DOID:0110735); neurodegeneration with brain iron accumulation 2b (Disease Ontology:DOID:0110736); pleurisy (Disease Ontology:DOID:10247); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); neuroaxonal dystrophy (Disease Ontology:DOID:2367)", "pathway": " (mmu:53357); (R-MMU-1482788); (R-MMU-1482839); (R-MMU-2029485); (R-MMU-6811436)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "11563837;12167650;15024020;17895289;18305254;18937505;21750661;21813701;22645316;24648512;25428506;30084848;31599954;34428180;38198970;39294744;9079688", "class_list": "", "function": "Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:18937505). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (By similarity). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (PubMed:24648512). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:18937505). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (By similarity). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G protein receptors in various cell types. Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (PubMed:17895289)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; IPLA(2)beta and iPLA(2)gamma are required for the adipogenic program that drives resting 3T3-L1 cells into adipocytes after hormone stimulation, [RefSeq, PubMed]; IPLA2beta loss leads to age-related cognitive decline and neuroinflammation by disrupting neuronal mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1alpha activation., [RefSeq, PubMed]; These findings support an RNA-dependent protein kinase-independent signaling role for iPLA(2) in the antiviral response of macrophages and the stimulation of inducible nitric oxide synthase expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99LA9;Q9JK61", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0017171 serine hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0046473 phosphatidic acid metabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P97819-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q149T7-1", "uniprot_id": [ { "id": "PPM1J_MOUSE", "url": "https://www.uniprot.org/uniprot/Q149T7", "type": "external" } ], "mass": 55550.0, "length": 507, "protein_name": "Protein phosphatase 1J", "gene_name": "Ppm1j", "organism": "Mouse", "refseq_name": "protein phosphatase 1J", "refseq_ac": [ { "id": "NP_082258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082258", "type": "external" } ], "gene_names_uniprotkb": "Ppm1j; Ppp2cz", "gene_names_refseq": "2310008J22Rik; PP2Czeta; Ppm1j; Ppp2cz", "protein_names_uniprotkb": "Protein phosphatase 1J; 3.1.3.16; PP2C-zeta; Protein phosphatase 2C isoform zeta", "protein_names_refseq": "PP2C-zeta; protein phosphatase 1J; protein phosphatase 2C zeta", "tax_id": 10090, "disease": "", "pathway": " (mmu:71887)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12633878;18553930;19144319;21183079;30084848", "class_list": "", "function": "These results suggest that specific phosphorylation of PP2Czeta at Ser (92) by stress-activated JNK attenuates its phosphatase activity in cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q810X6;Q9D7H6", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q149T7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YFS2-1", "uniprot_id": [ { "id": "PILRB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2YFS2", "type": "external" } ], "mass": 25200.0, "length": 224, "protein_name": "Paired immunoglobulin-like type 2 receptor beta", "gene_name": "Pilrb1; Pilrb", "organism": "Mouse", "refseq_name": "paired immunoglobulin-like type 2 receptor beta precursor", "refseq_ac": [ { "id": "NP_573472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573472", "type": "external" } ], "gene_names_uniprotkb": "Pilrb1; Pilrb; Fdfact; Pilrb1", "gene_names_refseq": "FDFACT; Fdact; Pilrb1; Pilrb", "protein_names_uniprotkb": "Paired immunoglobulin-like type 2 receptor beta; Activating receptor PILR-beta; Cell surface receptor FDFACT", "protein_names_refseq": "activating receptor PILR-beta; immunoglobulin-like cell surface receptor FDFACT, activating counterpart; paired immunoglobulin-like type 2 receptor beta precursor; paired immunoglobulin-like type 2 receptor beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:170741)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14970179;20065029;21750661;22479310;31385804", "class_list": "", "function": "Activation of PILRa or deletion of PILRb helps to control acute Staphylococcus aureus-mediated pneumonia and attenuate the inflammatory response., [RefSeq, PubMed]; Data show that PILRbeta is important for regulating aberrant inflammatory responses through IL-27 production., [RefSeq, PubMed]; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells., [UniProtKB, PubMed]; Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0045671 negative regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2YFS2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TB82-1", "uniprot_id": [ { "id": "PKHF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TB82", "type": "external" } ], "mass": 31158.0, "length": 279, "protein_name": "Pleckstrin homology domain-containing family F member 1", "gene_name": "Plekhf1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family F member 1", "refseq_ac": [ { "id": "NP_077724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077724", "type": "external" } ], "gene_names_uniprotkb": "Plekhf1; Lapf", "gene_names_refseq": "1810013P09Rik; APPD; LAPF; PHAFIN1; Plekhf1; ZFYVE15", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 1; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; PH domain-containing family F member 1", "protein_names_refseq": "PH domain-containing family F member 1; lysosome-associated apoptosis-inducing protein containing PH and FYVE domains; pleckstrin homology domain-containing family F member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:72287)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16188880;31189603;34428180", "class_list": "", "function": "May play a role in endosome function., [UniProtKB, UniProtKB]; Study identified LAPF (lysosome-associated and apoptosis-inducing protein containing PH and FYVE domains) as a Cav1-interacting protein by mass spectrometry and find that LAPF is critically involved in inducing innate immune responses and in enhancing bacterial endocytosis and the bactericide capacity of macrophages by inducing Src-LAPF-Caveolin complex formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99M16", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0008270 zinc ion binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TB82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TCN2-1", "uniprot_id": [ { "id": "PLBL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TCN2", "type": "external" } ], "mass": 66289.0, "length": 594, "protein_name": "Putative phospholipase B-like 2", "gene_name": "Plbd2", "organism": "Mouse", "refseq_name": "putative phospholipase B-like 2 precursor", "refseq_ac": [ { "id": "NP_076114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076114", "type": "external" } ], "gene_names_uniprotkb": "Plbd2", "gene_names_refseq": "1300012G16Rik; P76; Plbd2", "protein_names_uniprotkb": "Putative phospholipase B-like 2; 3.4.11.-; 66.3 kDa protein; 76 kDa protein; LAMA-like protein 2; Lamina ancestor homolog 2; Phospholipase B domain-containing protein 2; p76", "protein_names_refseq": "66.3 kDa protein; 76 kDa protein; LAMA-like protein 2; lamina ancestor homolog 2; phospholipase B domain-containing protein 2; putative phospholipase B-like 2 precursor; putative phospholipase B-like 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:71772)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;12080145;17007843;17105447;19237744;19706171;26495903;26740625;30899004;31219806;34203471;34428180;37828378;40021952;40885482", "class_list": "", "function": "A 22-atom substructure of 21 intrinsic S atoms & 1 Xe atom with very low occupancy was found & refined at a resolution of 2.4A. The model was refined to an R(free) factor of 19.8%. The contribution of the Xe atom to the anomalous signal was negligible., [RefSeq, PubMed]; Putative aminopeptidase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD43;Q3TPP8;Q8BHG8;Q8BMB6;Q8BXI3;Q8C0M4;Q8R0V3;Q9DBG4;Q9EQI9", "ec_number_list": [], "go_molecular_function": "GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q3TCN2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTY0-1", "uniprot_id": [ { "id": "PLB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTY0", "type": "external" } ], "mass": 164541.0, "length": 1478, "protein_name": "Phospholipase B1, membrane-associated", "gene_name": "Plb1", "organism": "Mouse", "refseq_name": "phospholipase B1, membrane-associated isoform 1 precursor", "refseq_ac": [ { "id": "NP_001074876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074876", "type": "external" } ], "gene_names_uniprotkb": "Plb1; Plb", "gene_names_refseq": "4632413E21Rik; 4930433E17Rik; 4930539A06Rik; Plb1", "protein_names_uniprotkb": "Phospholipase B1, membrane-associated; 3.1.1.3; 3.1.1.4; 3.1.1.5; Lysophospholipase; PLB/LIP; Phospholipase A2; Phospholipase B/lipase; Phospholipase B; Triacylglycerol lipase", "protein_names_refseq": "PLB/LIP; lysophospholipase; phospholipase A2; phospholipase B/lipase; phospholipase B1, membrane-associated isoform 1 precursor; phospholipase B1, membrane-associated; triacylglycerol lipase", "tax_id": 10090, "disease": "", "pathway": " (mmu:665270); (R-MMU-1482788); (R-MMU-975634)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "23943622;31219806;36680377", "class_list": "", "function": "Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Pathogenicity of phospholipase B1 of Trichosporon asahii in immunosuppressed mice., [RefSeq, PubMed]; Sperm surface phospholipase B is activated in response to sterol removal, [RefSeq, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 6, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q0VEX7;Q9D4Y6", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity", "go_cellular_component": "GO:0031526 brush border membrane", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0042572 retinol metabolic process;GO:0046340 diacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TTY0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60696-1", "uniprot_id": [ { "id": "PMEL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60696", "type": "external" } ], "mass": 66301.0, "length": 626, "protein_name": "Melanocyte protein PMEL", "gene_name": "Pmel", "organism": "Mouse", "refseq_name": "melanocyte protein PMEL precursor", "refseq_ac": [ { "id": "NP_068682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068682", "type": "external" } ], "gene_names_uniprotkb": "Pmel; D10H12S53E; Pmel17; Silv; Si", "gene_names_refseq": "D10H12S53E; D12S53Eh; Pmel17; Pmel; Silv; Si; gp100; gp87", "protein_names_uniprotkb": "Melanocyte protein PMEL; Melanocyte protein Pmel 17; Premelanosome protein; Silver locus protein", "protein_names_refseq": "melanocyte protein PMEL precursor; melanocyte protein pmel 17; silver locus protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20431)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10594241;11694580;12477932;16760433;21750661;21949658;25428506;26451316;30084848;30988362;40021952;7870580", "class_list": "", "function": "Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZB2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q60696-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60806-1", "uniprot_id": [ { "id": "PLK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60806", "type": "external" } ], "mass": 70012.0, "length": 631, "protein_name": "Serine/threonine-protein kinase PLK3", "gene_name": "Plk3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plk3; Cnk; Fnk", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK3; 2.7.11.21; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; PLK-3; Polo-like kinase 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (R-MMU-6804115); (R-MMU-6804756); (R-MMU-69601)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11039900;18519666;19188452;20940307;21376736;21750661;25605945;31219806;7730342;9677325", "class_list": "", "function": "Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60822;Q9R009", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0002039 p53 binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0044819 mitotic G1/S transition checkpoint signaling;GO:1904716 positive regulation of chaperone-mediated autophagy;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006970 response to osmotic stress;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q60806-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61878-1", "uniprot_id": [ { "id": "PRG2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61878", "type": "external" } ], "mass": 24255.0, "length": 223, "protein_name": "Bone marrow proteoglycan", "gene_name": "Prg2", "organism": "Mouse", "refseq_name": "bone marrow proteoglycan precursor", "refseq_ac": [ { "id": "NP_032946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032946", "type": "external" } ], "gene_names_uniprotkb": "Prg2; Mbp-1", "gene_names_refseq": "EMBP; MBP; Prg2; mMBP-1; mMBP", "protein_names_uniprotkb": "Bone marrow proteoglycan; BMPG; Proteoglycan 2", "protein_names_refseq": "BMPG; bone marrow proteoglycan precursor; bone marrow proteoglycan; major basic protein 1", "tax_id": 10090, "disease": "Chagas disease (Disease Ontology:DOID:12140); peritoneum cancer (Disease Ontology:DOID:1725); asthma (Disease Ontology:DOID:2841)", "pathway": " (mmu:19074); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18694936;31722215;39627609;40997131;7673718", "class_list": "glycogene", "function": "Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity)., [UniProtKB]; The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 24, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006955 immune response;GO:0042742 defense response to bacterium;GO:0002215 defense response to nematode;GO:0032753 positive regulation of interleukin-4 production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61878-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62028-1", "uniprot_id": [ { "id": "PLA2R_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62028", "type": "external" } ], "mass": 170512.0, "length": 1487, "protein_name": "Secretory phospholipase A2 receptor", "gene_name": "Pla2r1", "organism": "Mouse", "refseq_name": "secretory phospholipase A2 receptor precursor", "refseq_ac": [ { "id": "NP_032893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032893", "type": "external" } ], "gene_names_uniprotkb": "Pla2r1; Pla2g1br", "gene_names_refseq": "Pla2-r; Pla2g1br; Pla2r1; Pla2r", "protein_names_uniprotkb": "Secretory phospholipase A2 receptor; 180 kDa secretory phospholipase A2 receptor; M-type receptor; PLA2-R; PLA2R", "protein_names_refseq": "180 kDa secretory phospholipase A2 receptor; M-type receptor; PLA2-I receptor; phospholipase A2, group IB, pancreas, receptor; secretory phospholipase A2 receptor precursor; secretory phospholipase A2 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:18779); (R-MMU-1482788); (R-MMU-1482801); (R-MMU-1482839); (R-MMU-1482922); (R-MMU-1482925); (R-MMU-1483166)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10066760;10864436;10922494;10946309;11019817;11481246;11741598;11830583;12225974;16815622;17279628;32016628;33594040;34428180;37667516;7925459;9407054", "class_list": "glycogene", "function": "Deficiency of Phospholipase A2 Receptor Exacerbates Autoimmune Myocarditis in Mice., [RefSeq, PubMed]; Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western diets., [RefSeq, PubMed]; PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 98, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A2AS64;B9EJ68;Q80ZL5", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0043274 phospholipase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0006898 receptor-mediated endocytosis;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0072593 reactive oxygen species metabolic process;GO:1904635 positive regulation of podocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q62028-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6A025-1", "uniprot_id": [ { "id": "PPR26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6A025", "type": "external" } ], "mass": 124934.0, "length": 1163, "protein_name": "Protein phosphatase 1 regulatory subunit 26", "gene_name": "Ppp1r26", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 26", "refseq_ac": [ { "id": "NP_001005420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005420", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r26; Gm347; Kiaa0649", "gene_names_refseq": "Gm347; Kiaa0649; Ppp1r26; mKIAA0649", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 26", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:241289)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16053918", "class_list": "", "function": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS64", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6A025-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NVE9-1", "uniprot_id": [ { "id": "PPTC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NVE9", "type": "external" } ], "mass": 33048.0, "length": 310, "protein_name": "Protein phosphatase PTC7 homolog", "gene_name": "Pptc7", "organism": "Mouse", "refseq_name": "protein phosphatase PTC7 homolog", "refseq_ac": [ { "id": "NP_796216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796216", "type": "external" } ], "gene_names_uniprotkb": "Pptc7; Tapp2c", "gene_names_refseq": "9130017A15Rik; Pptc7; TA-PP2C", "protein_names_uniprotkb": "Protein phosphatase PTC7 homolog; 3.1.3.16; T-cell activation protein phosphatase 2C; TA-PP2C", "protein_names_refseq": "T-cell activation protein phosphatase 2C; protein phosphatase PTC7 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:320717)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "31219806;31324765;34203471;34428180;37833277;38151018", "class_list": "", "function": "PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:31324765). Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (PubMed:37833277, PubMed:38151018). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (PubMed:37833277). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38151018)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS53;Q8BVC7", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0000423 mitophagy;GO:0010795 regulation of ubiquinone biosynthetic process;GO:1904775 positive regulation of ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6NVE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NZN1-1", "uniprot_id": [ { "id": "PPRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NZN1", "type": "external" } ], "mass": 175074.0, "length": 1644, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator-related protein 1", "gene_name": "Pprc1", "organism": "Mouse", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001074683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074683", "type": "external" } ], "gene_names_uniprotkb": "Pprc1; Kiaa0595", "gene_names_refseq": "A930018M19; PRC; Pprc1; mKIAA0595", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC", "protein_names_refseq": "PGC-1-related coactivator; peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1; peroxisome proliferator-activated receptor gamma coactivator-related protein 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:226169)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11340167;16908542;21750661;22411706;25994039;31219806;33300544;35820727", "class_list": "", "function": "Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity)., [UniProtKB]; Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates., [RefSeq, PubMed]; These results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGG3;Q80TW6;Q8BXP6;Q91YW8", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6NZN1-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT52-1", "uniprot_id": [ { "id": "PP14D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT52", "type": "external" } ], "mass": 16817.0, "length": 146, "protein_name": "Protein phosphatase 1 regulatory subunit 14D", "gene_name": "Ppp1r14d", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 14D isoform a", "refseq_ac": [ { "id": "NP_001277725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277725", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14d; Gbpi", "gene_names_refseq": "2010107K19Rik; GBPI-1; Ppp1r14d; Ppp1r14", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14D; GBPI-1; Gastrointestinal and brain-specific PP1-inhibitory protein 1", "protein_names_refseq": "PKC-dependent PP1 inhibitory protein subunit 14; gastrointestinal and brain-specific PP1-inhibitory protein 1; protein phosphatase 1 regulatory subunit 14D isoform a; protein phosphatase 1 regulatory subunit 14D", "tax_id": 10090, "disease": "", "pathway": " (mmu:72112)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12974676", "class_list": "", "function": "Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AV57;Q9D878", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TT52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZA4-1", "uniprot_id": [ { "id": "PKHL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZA4", "type": "external" } ], "mass": 464732.0, "length": 4249, "protein_name": "Fibrocystin-L", "gene_name": "Pkhd1l1", "organism": "Mouse", "refseq_name": "fibrocystin-L precursor", "refseq_ac": [ { "id": "NP_619615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619615", "type": "external" } ], "gene_names_uniprotkb": "Pkhd1l1", "gene_names_refseq": "PKHDL1; Pkhd1l1", "protein_names_uniprotkb": "Fibrocystin-L; PKHD1-like protein 1; Polycystic kidney and hepatic disease 1-like protein 1; Protein D86", "protein_names_refseq": "PKHD1-like protein 1; fibrocystin L; fibrocystin-L precursor; polycystic kidney and hepatic disease 1-like protein 1", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565)", "pathway": " (mmu:192190)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;12620974;20048263;20485683;21750661;25428506;30084848;31444330;31599954;34428180;35820727;36067019;39482437;40885482", "class_list": "", "function": "Component of hair-cell stereocilia coat. Required for normal hearing., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Deficit of PKHD1L1 in the dentate gyrus increases seizure susceptibility in mice., [RefSeq, PubMed]; PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure. Publication Status: Online-Only, [RefSeq, PubMed]; PKHDL1 may have a role in cellular immunity, [RefSeq, PubMed]; Show that the fibrocystin ciliary targeting sequence is an 18-residue motif localized in the cytoplasmic tail., [RefSeq, PubMed]; Study showed that Pkhd1l1 is expressed at the tips of stereocilia, especially in the high-frequency regions of the cochlea. Pkhd1l1-deficient mice lack the surface coat at the upper but not lower regions of stereocilia, and they develop progressive hearing loss. Results suggest that Pkhd1l1 is a component of the surface coat and is required for normal hearing in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q99PS9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032426 stereocilium tip;GO:0060171 stereocilium membrane;GO:0120234 stereocilium coat", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q80ZA4-1", "record_type": "protein", "filter_code": "0000000.1000111.001000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFY0-1", "uniprot_id": [ { "id": "PIRT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFY0", "type": "external" } ], "mass": 15264.0, "length": 135, "protein_name": "Phosphoinositide-interacting protein", "gene_name": "Pirt", "organism": "Mouse", "refseq_name": "phosphoinositide-interacting protein", "refseq_ac": [ { "id": "NP_848771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848771", "type": "external" } ], "gene_names_uniprotkb": "Pirt", "gene_names_refseq": "A530088H08Rik; Pirt", "protein_names_uniprotkb": "Phosphoinositide-interacting protein", "protein_names_refseq": "phosphoinositide-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:193003)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18455988;21655234;23863968", "class_list": "", "function": "Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent., [RefSeq, PubMed]; Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity., [RefSeq, PubMed]; Pirt regulates the function of TRPM8 and its role in detecting cold., [RefSeq, PubMed]; Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051930 regulation of sensory perception of pain;GO:2001259 positive regulation of cation channel activity;GO:0009408 response to heat;GO:0048266 behavioral response to pain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BFY0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG07-1", "uniprot_id": [ { "id": "PLD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG07", "type": "external" } ], "mass": 56154.0, "length": 503, "protein_name": "5'-3' exonuclease PLD4", "gene_name": "Pld4", "organism": "Mouse", "refseq_name": "5'-3' exonuclease PLD4", "refseq_ac": [ { "id": "NP_849242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849242", "type": "external" } ], "gene_names_uniprotkb": "Pld4", "gene_names_refseq": "Pld4; thss", "protein_names_uniprotkb": "5'-3' exonuclease PLD4; (S,S)-bis(monoacylglycero)phosphate synthase PLD4; 2.3.1.-; 3.1.16.1; Phospholipase D family member 4; Phospholipase D4", "protein_names_refseq": "(S,S)-bis(monoacylglycero)phosphate synthase PLD4; 5'-3' exonuclease PLD4; PLD 4; choline phosphatase 4; phosphatidylcholine-hydrolyzing phospholipase D4; phospholipase D4", "tax_id": 10090, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:104759); (R-MMU-1855204); (R-MMU-2029485)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;18250455;21085684;21913724;22102906;25428506;26495903;26740625;28011936;30111894;30679154;30899004;32069316;34428180;34620855;35984892;38537643;39423811;39627609;40931063", "class_list": "", "function": "Can alternatively catalyze the transfer (transphosphatidylation) of a glycerol group between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG). The reaction is characterized by an R-to-S stereo-inversion which is essential for the resistance of the produced (S,S)-bis(monoacylglycero)phosphates (BMPs) to lysosomal degradation. The resulting BMPs, are phospholipids required for the formation of lysosomal intralumenal vesicles (ILVs) where lipid degradation can occur., [UniProtKB, PubMed]; Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors. Publication Status: Online-Only, [RefSeq, PubMed]; Lysosomal 5'->3' exonuclease that functions in nucleic-acid sensing by immune cells (PubMed:30111894, PubMed:34620855, PubMed:38537643, PubMed:40931063). Hydrolyzes phosphodiester bond in single-stranded RNA and DNA molecules, with a higher efficiency for molecules with 5' uridine and guanosine residues. It can stall at certain sites and does not necessarily proceed to complete exonucleolytic degradation, thereby producing nucleoside 3'-monophosphates but also 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments (PubMed:30111894, PubMed:34620855, PubMed:38537643). Through the processing of self and exogenous RNA and DNA molecules, provides molecular signals to toll-like receptors (TLRs) in innate immunity. Partially redundant with PLD3, it cooperates with the RNase T2/RNASET2 to generate 2',3'-cGMP and cytidine-rich RNA fragments that occupy the two TLR7 ligand-binding pockets, to trigger receptor activation and signaling (By similarity). Can exert polynucleotide phosphatase activity toward 5'-phosphorylated single-stranded DNA substrates although at a slow rate (PubMed:38537643). Could play a role in phagocytosis of activated microglia (PubMed:22102906)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Pld4 mutant mice revealed autoimmune phenotypes suggesting functional involvement of PLD4 with the basics of systemic lupus erythematosus., [RefSeq, PubMed]; Results showed that PLD4 is a non-PLD, HKD motif-carrying, transmembrane glycoprotein localized in the endoplasmic reticulum and Golgi apparatus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD59;Q3UA19;Q6PDR0;Q8BR69", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0004534 5'-3' RNA exonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0032588 trans-Golgi network membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006909 phagocytosis;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q8BG07-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHK0-1", "uniprot_id": [ { "id": "PNMA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHK0", "type": "external" } ], "mass": 41201.0, "length": 365, "protein_name": "Paraneoplastic antigen Ma2 homolog", "gene_name": "Pnma2", "organism": "Mouse", "refseq_name": "paraneoplastic antigen Ma2 homolog", "refseq_ac": [ { "id": "NP_780707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780707", "type": "external" } ], "gene_names_uniprotkb": "Pnma2", "gene_names_refseq": "A830049P17Rik; Pnma2; mKIAA0883", "protein_names_uniprotkb": "Paraneoplastic antigen Ma2 homolog", "protein_names_refseq": "paraneoplastic antigen Ma2 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:239157)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19366867", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKK4-1", "uniprot_id": [ { "id": "PPR1C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKK4", "type": "external" } ], "mass": 12303.0, "length": 108, "protein_name": "Protein phosphatase 1 regulatory subunit 1C", "gene_name": "Ppp1r1c", "organism": "Mouse", "refseq_name": "protein phosphatase 1 regulatory subunit 1C isoform b", "refseq_ac": [ { "id": "NP_001277672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277672", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r1c", "gene_names_refseq": "4930565M23Rik; 4930579P15Rik; Ppp1r1c", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 1C", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 1C isoform b; protein phosphatase 1 regulatory subunit 1C", "tax_id": 10090, "disease": "", "pathway": " (mmu:75276)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20512582", "class_list": "", "function": "May increase cell susceptibility to TNF-induced apoptosis., [UniProtKB, UniProtKB]; Mitochondrial signaling and ERK activation may be involved in the I-1c cardioprotective effects against apoptosis induced by prolonged beta-adrenergic stimulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQD1;Q3TZG5;Q8BKM4", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BKK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP40-1", "uniprot_id": [ { "id": "PPA6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP40", "type": "external" } ], "mass": 47625.0, "length": 418, "protein_name": "Lysophosphatidic acid phosphatase type 6", "gene_name": "Acp6", "organism": "Mouse", "refseq_name": "lysophosphatidic acid phosphatase type 6 precursor", "refseq_ac": [ { "id": "NP_062774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062774", "type": "external" } ], "gene_names_uniprotkb": "Acp6; Acpl1; Lpap", "gene_names_refseq": "5730559A09Rik; ACPL1; Acp6; mPACPL1", "protein_names_uniprotkb": "Lysophosphatidic acid phosphatase type 6; 3.1.3.106; Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1", "protein_names_refseq": "PACPL1; acid phosphatase like 1; acid phosphatase-like protein 1; lysophosphatidic acid phosphatase type 6 precursor; lysophosphatidic acid phosphatase type 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66659); (R-MMU-1483166)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12010880;12837850;37507081", "class_list": "", "function": "Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNE2;Q8BN33;Q9JMG5;Q9QXG5", "ec_number_list": [ { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0003993 acid phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:2001311 lysobisphosphatidic acid metabolic process;GO:0002244 hematopoietic progenitor cell differentiation;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BP40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU27-3", "uniprot_id": [ { "id": "PPM1M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU27", "type": "external" } ], "mass": 51204.0, "length": 462, "protein_name": "Protein phosphatase 1M", "gene_name": "Ppm1m", "organism": "Mouse", "refseq_name": "protein phosphatase 1M isoform 2", "refseq_ac": [ { "id": "NP_945149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_945149", "type": "external" } ], "gene_names_uniprotkb": "Ppm1m; Ppm1e", "gene_names_refseq": "2810423O19Rik; PP2Ceta; Ppm1m", "protein_names_uniprotkb": "Protein phosphatase 1M; 3.1.3.16; PP2C-eta; PP2CE; Protein phosphatase 2C isoform eta", "protein_names_refseq": "PP2C-eta; PP2CE; protein phosphatase 1M isoform 2; protein phosphatase 2C eta-2; protein phosphatase 2C eta", "tax_id": 10090, "disease": "", "pathway": " (mmu:67905)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14654243", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2I3;Q9CSD6;Q9CU88", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0030145 manganese ion binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BU27-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW88-1", "uniprot_id": [ { "id": "PKHS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW88", "type": "external" } ], "mass": 53077.0, "length": 474, "protein_name": "Pleckstrin homology domain-containing family S member 1", "gene_name": "Plekhs1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family S member 1 isoform 2", "refseq_ac": [ { "id": "NP_001157735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157735", "type": "external" } ], "gene_names_uniprotkb": "Plekhs1", "gene_names_refseq": "9930023K05Rik; Plekhs1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family S member 1; PH domain-containing family S member 1", "protein_names_refseq": "PH domain-containing family S member 1; PH domain-containing protein C10orf81 homolog; pleckstrin homology domain-containing family S member 1 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226245)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35820727;37567175", "class_list": "", "function": "PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QMW0;Q5EAT4;Q8BZ18;Q8R5A9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BW88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZW8-1", "uniprot_id": [ { "id": "PNMA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZW8", "type": "external" } ], "mass": 54041.0, "length": 466, "protein_name": "Paraneoplastic antigen Ma3 homolog", "gene_name": "Pnma3", "organism": "Mouse", "refseq_name": "paraneoplastic antigen Ma3 homolog", "refseq_ac": [ { "id": "NP_694809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694809", "type": "external" } ], "gene_names_uniprotkb": "Pnma3", "gene_names_refseq": "Pnma3", "protein_names_uniprotkb": "Paraneoplastic antigen Ma3 homolog", "protein_names_refseq": "paraneoplastic antigen Ma3 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:245468)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19366867", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3URF3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8JZW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0J1-1", "uniprot_id": [ { "id": "PKHG6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0J1", "type": "external" } ], "mass": 89148.0, "length": 787, "protein_name": "Pleckstrin homology domain-containing family G member 6", "gene_name": "Plekhg6", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family G member 6", "refseq_ac": [ { "id": "NP_941006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941006", "type": "external" } ], "gene_names_uniprotkb": "Plekhg6", "gene_names_refseq": "Gm155; Plekhg6", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 6; PH domain-containing family G member 6", "protein_names_refseq": "PH domain-containing family G member 6; pleckstrin homology domain-containing family G member 6", "tax_id": 10090, "disease": "cystic fibrosis (Disease Ontology:DOID:1485)", "pathway": " (mmu:213522); (R-MMU-8980692); (R-MMU-9013149)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20634288;30084848;34428180;35820727", "class_list": "", "function": "GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion., [RefSeq, PubMed]; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QJZ0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0030054 cell junction;GO:0032154 cleavage furrow", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R0J1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCE9-1", "uniprot_id": [ { "id": "PKHH3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCE9", "type": "external" } ], "mass": 85842.0, "length": 796, "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "Plekhh3", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family H member 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001333698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333698", "type": "external" } ], "gene_names_uniprotkb": "Plekhh3", "gene_names_refseq": "Plekhh3", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 3; PH domain-containing family H member 3", "protein_names_refseq": "PH domain-containing family H member 3; pleckstrin homology domain-containing family H member 3 isoform 2 precursor; pleckstrin homology domain-containing family H member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:217198)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34203471", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U3Z6;Q8R1H2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VCE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE85-1", "uniprot_id": [ { "id": "PLD3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE85", "type": "external" } ], "mass": 19026.0, "length": 172, "protein_name": "PRELI domain containing protein 3A", "gene_name": "Prelid3a", "organism": "Mouse", "refseq_name": "PRELI domain containing protein 3A isoform 3", "refseq_ac": [ { "id": "NP_659116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659116", "type": "external" } ], "gene_names_uniprotkb": "Prelid3a; Slmo1", "gene_names_refseq": "A230074A19Rik; Prelid3a; Slmo1", "protein_names_uniprotkb": "PRELI domain containing protein 3A; Protein slowmo homolog 1", "protein_names_refseq": "PRELI domain containing protein 3A isoform 3; PRELI domain containing protein 3A; protein slowmo homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225655); (R-MMU-6803204)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VE85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI78-1", "uniprot_id": [ { "id": "PLA1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VI78", "type": "external" } ], "mass": 49984.0, "length": 456, "protein_name": "Phospholipase A1 member A", "gene_name": "Pla1a", "organism": "Mouse", "refseq_name": "phospholipase A1 member A precursor", "refseq_ac": [ { "id": "NP_598863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598863", "type": "external" } ], "gene_names_uniprotkb": "Pla1a; Pspla1", "gene_names_refseq": "Pla1a; Ps-pla1; Pspla1", "protein_names_uniprotkb": "Phospholipase A1 member A; 3.1.1.111; PS-PLA1; Phosphatidylserine-specific phospholipase A1", "protein_names_refseq": "phosphatidylserine-specific phospholipase A1; phospholipase A1 member A precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:85031); (R-MMU-1482801)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11210182;20484733;21857648;25428506;30084848;31599954;34428180;37828378", "class_list": "", "function": "A phosphatidic acid-phospholipase A1alpha-lysophosphatidic acid-P2Y5 axis regulates differentiation of hair follicles via a tumour necrosis factor alpha converting enzyme-transforming growth factor alpha-epidermal growth factor receptor pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (By similarity). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9QN71;Q99J51", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008970 phospholipase A1 activity;GO:0120560 phosphatidylserine lysophospholipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8VI78-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JY8-1", "uniprot_id": [ { "id": "PLPP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JY8", "type": "external" } ], "mass": 35216.0, "length": 312, "protein_name": "Phospholipid phosphatase 3", "gene_name": "Plpp3", "organism": "Mouse", "refseq_name": "phospholipid phosphatase 3", "refseq_ac": [ { "id": "NP_542122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542122", "type": "external" } ], "gene_names_uniprotkb": "Plpp3; Lpp3; Ppap2b", "gene_names_refseq": "1110003O22Rik; 2610002D05Rik; D4Bwg0538e; D4Bwg1535e; Lpp3; PRG-2; Plpp3; Ppab2b; Ppap2b", "protein_names_uniprotkb": "Phospholipid phosphatase 3; 3.1.3.-; 3.1.3.4; Lipid phosphate phosphohydrolase 3; PAP-2b; PAP2-beta; PAP2b; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b", "protein_names_refseq": "PAP-2b; PAP2-beta; PAP2b; lipid phosphate phosphohydrolase 3; phosphatidate phosphohydrolase type 2b; phosphatidic acid phosphatase 2b; phosphatidic acid phosphatase type 2B; phospholipid phosphatase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67916); (R-MMU-9845614)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12925589;16099422;17610274;19123136;21319224;27125875;29889835;30899004;34428180;36453277;36504260;36717587", "class_list": "glycogene", "function": "Data show that mouse embryos deficient for lipid phosphate phosphatase 3 fail to form a chorio-allantoic placenta and yolk sac vasculature., [RefSeq, PubMed]; FTO-dependent m[6]A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:12925589, PubMed:27125875). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:16099422)., [UniProtKB, PubMed, PubMed, PubMed]; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (By similarity). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (PubMed:21319224). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (By similarity)., [UniProtKB, UniProtKB, PubMed]; Myeloid-Specific Deletion of Lipid Plpp3 (Phosphate Phosphatase 3) Increases Cardiac Inflammation After Myocardial Infarction., [RefSeq, PubMed]; Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells., [RefSeq, PubMed]; Provide a mechanism for the function of LPP3 in cell-cell interactions in both human and mouse, [RefSeq, PubMed]; Targeted inactivation results in embryonic lethality because of defects in extraembryonic vascular development and gastrulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 15, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVM4;Q3TXR7;Q8BTB7", "ec_number_list": [ { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:0070097 delta-catenin binding;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99JY8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPS7-1", "uniprot_id": [ { "id": "PNO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPS7", "type": "external" } ], "mass": 27454.0, "length": 248, "protein_name": "RNA-binding protein PNO1", "gene_name": "Pno1", "organism": "Mouse", "refseq_name": "RNA-binding protein PNO1", "refseq_ac": [ { "id": "NP_079719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079719", "type": "external" } ], "gene_names_uniprotkb": "Pno1", "gene_names_refseq": "1810003N24Rik; Emi3; Imi3; Pno1", "protein_names_uniprotkb": "RNA-binding protein PNO1", "protein_names_refseq": "RNA-binding protein PNO1; expressed during mesenchymal induction 3; induced during mesenchymal induction 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66249); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15497447;23029399;25428506;36210013", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA., [UniProtKB, UniProtKB]; Pno1 gene knockout is Lethal in Embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CPS7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQD7-1", "uniprot_id": [ { "id": "PINLY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQD7", "type": "external" } ], "mass": 22819.0, "length": 212, "protein_name": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein", "gene_name": "Pinlyp", "organism": "Mouse", "refseq_name": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor", "refseq_ac": [ { "id": "NP_001032220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032220", "type": "external" } ], "gene_names_uniprotkb": "Pinlyp", "gene_names_refseq": "2310033E01Rik; Pinlyp", "protein_names_uniprotkb": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein", "protein_names_refseq": "phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein precursor; phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:641361)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34969857", "class_list": "", "function": "Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D6V5", "ec_number_list": [], "go_molecular_function": "GO:0004859 phospholipase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CWW6-1", "uniprot_id": [ { "id": "PIN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CWW6", "type": "external" } ], "mass": 13815.0, "length": 131, "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4", "gene_name": "Pin4", "organism": "Mouse", "refseq_name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1", "refseq_ac": [ { "id": "NP_081457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081457", "type": "external" } ], "gene_names_uniprotkb": "Pin4", "gene_names_refseq": "2410002I22Rik; EPVH; Par14; Pin4", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 5.2.1.8; PPIase Pin4; Par14; Parvulin-14; Peptidyl-prolyl cis-trans isomerase Pin4; Rotamase Pin4", "protein_names_refseq": "PPIase Pin4; parvulin-14; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; peptidyl-prolyl cis-trans isomerase Pin4; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin); rotamase Pin4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69713)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11960984;23720771;31219806;34428180;36288343", "class_list": "", "function": "Data indicate the association of Par14 with insulin receptor substrate 1 (IRS-1) in human HepG2 cells overexpressing both as well as endogenously in the mouse liver., [RefSeq, PubMed]; Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE57", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003681 bent DNA binding;GO:0003690 double-stranded DNA binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0030684 preribosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CWW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D358-1", "uniprot_id": [ { "id": "PPAC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D358", "type": "external" } ], "mass": 18192.0, "length": 158, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase", "gene_name": "Acp1", "organism": "Mouse", "refseq_name": "low molecular weight phosphotyrosine protein phosphatase isoform 1", "refseq_ac": [ { "id": "NP_001103709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103709", "type": "external" } ], "gene_names_uniprotkb": "Acp1", "gene_names_refseq": "4632432E04Rik; Acp-1; Acp1; LMW-PTP; Lmptp", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase; 3.1.3.2; 3.1.3.48; LMW-PTPase; LMW-PTP; Low molecular weight cytosolic acid phosphatase", "protein_names_refseq": "LMW-PTPase; low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase isoform 1; low molecular weight phosphotyrosine protein phosphatase", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); coronary artery disease (Disease Ontology:DOID:3393); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:11431)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "18058037;21750661;26213100;33615467;34428180;35820727;9824304", "class_list": "", "function": "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2., [UniProtKB, UniProtKB]; Our data show that ablation of Lmptp inhibits pathological cardiac remodelling, [RefSeq, PubMed]; The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88739;O88740;Q9QWF5", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0003993 acid phosphatase activity;GO:0016791 phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D358-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI83-1", "uniprot_id": [ { "id": "PLAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI83", "type": "external" } ], "mass": 19626.0, "length": 173, "protein_name": "Placenta-specific protein 1", "gene_name": "Plac1", "organism": "Mouse", "refseq_name": "placenta-specific protein 1 precursor", "refseq_ac": [ { "id": "NP_062411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062411", "type": "external" } ], "gene_names_uniprotkb": "Plac1", "gene_names_refseq": "DXWsu72e; Epcs26; Oosp2l; Plac1", "protein_names_uniprotkb": "Placenta-specific protein 1; EPCS26", "protein_names_refseq": "ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 26; placenta-specific protein 1 precursor; placenta-specific protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56096)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10885754;10995572;29632317;29723063;36084365", "class_list": "", "function": "Immunization with placenta-specific 1 (plac1) induces potent anti-tumor responses and prolongs survival in a mouse model of melanoma., [RefSeq, PubMed]; May play a role in placental development., [UniProtKB, PubMed]; Results provide evidence that Plac1 modulates a tolerogenic tumor microenvironment in part by modulating the chemokine axis in mammary tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Upon meiosis onset, active furin/IGF-1 receptor relocates into the cytoplasm to activate (phosphorylate) Akt to promote meiosis. In summary, our finding suggests that Plac1, a protein that is crucial for placentation, is also essential for oocyte meiosis and fertilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKT4;Q80WW3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001890 placenta development;GO:0090214 spongiotrophoblast layer developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JI83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ00-1", "uniprot_id": [ { "id": "PLS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ00", "type": "external" } ], "mass": 35914.0, "length": 328, "protein_name": "Phospholipid scramblase 1", "gene_name": "Plscr1", "organism": "Mouse", "refseq_name": "phospholipid scramblase 1", "refseq_ac": [ { "id": "NP_035766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035766", "type": "external" } ], "gene_names_uniprotkb": "Plscr1; Tra1b; Tras1", "gene_names_refseq": "MmTRA1a; MmTRA1b; Nor1; Plscr1; Tra1a; Tra1b; Tra1; Tras1; Tras2", "protein_names_uniprotkb": "Phospholipid scramblase 1; 3.1.-.-; Ca(2+)-dependent phospholipid scramblase 1; Mg(2+)-dependent nuclease; NOR1; PL scramblase 1; TRA1; Transplantability-associated protein 1", "protein_names_refseq": "PL scramblase 1; ca(2+)-dependent phospholipid scramblase 1; mg(2+)-dependent nuclease; phospholipid scramblase 1; transplantability-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22038)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10930526;12010804;26745724;32110987;34428180;35595813;35820727;37438530;37453647;39312982;9108418", "class_list": "", "function": "Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific distribution of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface (PubMed:32110987). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (PubMed:32110987). Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A (By similarity). Negatively regulates FcR-mediated phagocytosis in differentiated macrophages (PubMed:26745724). May contribute to cytokine-regulated cell proliferation and differentiation (PubMed:12010804)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection., [RefSeq, PubMed]; Transcriptome analysis unveils PLSCR1 associated with microglial polarization in neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54730;O54731;Q9D1F8", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0032791 lead ion binding;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0006955 immune response;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JJ00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL95-1", "uniprot_id": [ { "id": "PRG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL95", "type": "external" } ], "mass": 25204.0, "length": 222, "protein_name": "Proteoglycan 3", "gene_name": "Prg3", "organism": "Mouse", "refseq_name": "proteoglycan 3 precursor", "refseq_ac": [ { "id": "NP_058610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058610", "type": "external" } ], "gene_names_uniprotkb": "Prg3; Mbp2", "gene_names_refseq": "MBP2; MBPH; Prg3", "protein_names_uniprotkb": "Proteoglycan 3; Eosinophil major basic protein 2", "protein_names_refseq": "eosinophil major basic protein 2; proteoglycan 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:53856); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10770291", "class_list": "glycogene", "function": "Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 21, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AW01;Q3SXA9", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "", "go_biological_process": "GO:0006955 immune response;GO:0017148 negative regulation of translation;GO:0032757 positive regulation of interleukin-8 production;GO:0019370 leukotriene biosynthetic process;GO:0042119 neutrophil activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JL95-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLG4-1", "uniprot_id": [ { "id": "PK2L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLG4", "type": "external" } ], "mass": 73683.0, "length": 621, "protein_name": "Polycystin-2-like protein 2", "gene_name": "Pkd2l2", "organism": "Mouse", "refseq_name": "polycystin-2-like protein 2", "refseq_ac": [ { "id": "NP_001156476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156476", "type": "external" } ], "gene_names_uniprotkb": "Pkd2l2", "gene_names_refseq": "Pkd2l2; TRPP5", "protein_names_uniprotkb": "Polycystin-2-like protein 2; Polycystic kidney disease 2-like 2 protein; Polycystin-2L2; Polycystin-L2", "protein_names_refseq": "Polycystin - L2; polycystic kidney disease 2-like 2 protein; polycystin-2-like protein 2; polycystin-2L2; polycystin-L2", "tax_id": 10090, "disease": "polycystic kidney disease 2 (Disease Ontology:DOID:0110859); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (mmu:53871)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10756092;18670078;20043191;21508103", "class_list": "", "function": "All channel-forming isoforms of TRPP channels (polycystin-2, polycystin-L, and polycystin-2L2) were expressed in adult mouse lacrimal gland. Publication Status: Online-Only, [RefSeq, PubMed]; Exhibits a lower single conductance but no spontaneous channel activity (By similarity). May function as a regulator of calcium channels or a channel component involving Ca2(+) homeostasis (PubMed:20043191)., [UniProtKB, PubMed, UniProtKB]; Pkd2l2 may be involved in the mid-late stage of spermatogenesis through modulation of the intracellular calcium concentration., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RS50", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JLG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM99-1", "uniprot_id": [ { "id": "PRG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM99", "type": "external" } ], "mass": 115996.0, "length": 1054, "protein_name": "Proteoglycan 4", "gene_name": "Prg4", "organism": "Mouse", "refseq_name": "proteoglycan 4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001103616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103616", "type": "external" } ], "gene_names_uniprotkb": "Prg4; Msf; Szp", "gene_names_refseq": "CACP; DOL54; JCAP; MSF; Prg4; SZP; lubricin", "protein_names_uniprotkb": "Proteoglycan 4; Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan", "protein_names_refseq": "megakaryocyte-stimulating factor; proteoglycan 3; proteoglycan 4 isoform 2 precursor; superficial zone proteoglycan", "tax_id": 10090, "disease": "camptodactyly-arthropathy-coxa vara-pericarditis syndrome (Disease Ontology:DOID:0090127); pericarditis (Disease Ontology:DOID:1787)", "pathway": " (mmu:96875)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11124536;15201968;15719068;16000300;21750661;31219806;34418053;34678516;38781792", "class_list": "glycogene", "function": "Expression is characteristic ofmyxoid liposarcoma and is also a frequent finding also in various other sarcomas., [RefSeq, PubMed]; PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression., [RefSeq, PubMed]; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface., [UniProtKB, PubMed]", "predicted_glycosites": 60, "predicted_n_glycosites": 2, "predicted_o_glycosites": 58, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 62, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEL1;Q3V198", "ec_number_list": [], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0006955 immune response;GO:0042127 regulation of cell population proliferation;GO:0032715 negative regulation of interleukin-6 production;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JM99-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXU1-1", "uniprot_id": [ { "id": "MED31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXU1", "type": "external" } ], "mass": 15771.0, "length": 131, "protein_name": "Mediator of RNA polymerase II transcription subunit 31", "gene_name": "Med31", "organism": "Mouse", "refseq_name": "mediator of RNA polymerase II transcription subunit 31", "refseq_ac": [ { "id": "NP_080344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080344", "type": "external" } ], "gene_names_uniprotkb": "Med31; Soh1", "gene_names_refseq": "3110004H13Rik; CGI-125; Med31; l11Jus15", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 31; Mediator complex subunit 31; Mediator complex subunit SOH1", "protein_names_refseq": "mediator complex subunit SOH1; mediator of RNA polymerase II transcription subunit 31; mediator of RNA polymerase II transcription, subunit 31 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67279)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23273896;31219806", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]; Elmo1 increased the cytoplasmic localization of Med31., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAP5", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048147 negative regulation of fibroblast proliferation;GO:0016567 protein ubiquitination;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUI1-1", "uniprot_id": [ { "id": "MK11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUI1", "type": "external" } ], "mass": 41397.0, "length": 364, "protein_name": "Mitogen-activated protein kinase 11", "gene_name": "Mapk11", "organism": "Mouse", "refseq_name": "mitogen-activated protein kinase 11", "refseq_ac": [ { "id": "NP_035291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035291", "type": "external" } ], "gene_names_uniprotkb": "Mapk11; Prkm11", "gene_names_refseq": "Mapk11; P38b; Prkm11; Sapk2b; Sapk2; p38-2; p38beta2; p38beta", "protein_names_uniprotkb": "Mitogen-activated protein kinase 11; 2.7.11.24; MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mitogen-activated protein kinase p38 beta; p38B", "protein_names_refseq": "MAP kinase 11; MAP kinase p38 beta; MAPK 11; mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; protein kinase, mitogen activated kinase, 11, p38beta", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:19094); (R-MMU-168638); (R-MMU-171007); (R-MMU-198753); (R-MMU-2559580); (R-MMU-4420097); (R-MMU-450302); (R-MMU-450341); (R-MMU-525793); (R-MMU-5668599); (R-MMU-6804756); (R-MMU-69601)", "pathway_count": 12, "publication_count": 6, "publication_id_list": "11909979;12384504;12452429;20004242;20626350;36210013", "class_list": "", "function": "P38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:11909979). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569F1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:1904784 NLRP1 inflammasome complex assembly;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WUI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYE9-1", "uniprot_id": [ { "id": "PKHB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYE9", "type": "external" } ], "mass": 27340.0, "length": 243, "protein_name": "Pleckstrin homology domain-containing family B member 1", "gene_name": "Plekhb1", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family B member 1 isoform b", "refseq_ac": [ { "id": "NP_001156654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156654", "type": "external" } ], "gene_names_uniprotkb": "Plekhb1; Evt1; Phr1", "gene_names_refseq": "PHR1; Phret1; Plekhb1; evt-1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family B member 1; Evectin-1; PH domain-containing family B member 1; PH domain-containing protein in retina 1; PHRET1; Pleckstrin homology domain retinal protein 1", "protein_names_refseq": "PH domain-containing family B member 1; PH domain-containing protein in retina 1; evectin-1; pleckstrin homology domain retinal protein 1; pleckstrin homology domain-containing family B member 1 isoform b; pleckstrin homology domain-containing family B member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:27276)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10585447;15456885;15976448;19371781;20301200;21750661;22985349;32686835", "class_list": "", "function": "A key presynaptic regulator of retinogeniculate layer placement independent of activity, segregation, or ephrin-A signaling, [RefSeq, PubMed]; Increased levels of PHR1 target proteins may be instructive for retinotopic mapping of retinofugal projections, [RefSeq, PubMed]; Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models., [RefSeq, PubMed]; Results describe the expression of specific Phr1 splice forms in olfactory receptor neurons and vestibular and cochlear hair cells as well as in photoreceptors, and show that mice lacking PHR1 do not have overt sensory deficits., [RefSeq, PubMed]; The PHR1 is expressed in the vestibular and cochlear sensory cells, its direct interactions with the myosin 1c and VIIa tails are likely to play a role in anchoring the actin cytoskeleton to the plasma membrane of these cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYB3;Q9QYB4;Q9QYD2;Q9QYD3", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QYE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0Q9-1", "uniprot_id": [ { "id": "RPGF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0Q9", "type": "external" } ], "mass": 93725.0, "length": 814, "protein_name": "Rap guanine nucleotide exchange factor 5", "gene_name": "Rapgef5", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor 5 isoform 2", "refseq_ac": [ { "id": "NP_787126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787126", "type": "external" } ], "gene_names_uniprotkb": "Rapgef5; Gfr; Kiaa0277; Mrgef", "gene_names_refseq": "4932413M22; D030051B22Rik; GFR; Mrgef; Rapgef5; mKIAA0277; mmr-gef", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF", "protein_names_refseq": "M-Ras-regulated Rap GEF; MR-GEF; Mras regulated guanine nucleotide exchange factor; guanine nucleotide exchange factor for Rap1; rap guanine nucleotide exchange factor 5 isoform 2; rap guanine nucleotide exchange factor 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217944)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25605945;30084848;34428180;36210013", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJJ9;Q8C0R5", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0007265 Ras protein signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C0Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8K8-1", "uniprot_id": [ { "id": "S2539_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8K8", "type": "external" } ], "mass": 39221.0, "length": 359, "protein_name": "Mitochondrial glutathione transporter SLC25A39", "gene_name": "Slc25a39", "organism": "Mouse", "refseq_name": "mitochondrial glutathione transporter SLC25A39", "refseq_ac": [ { "id": "NP_080818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080818", "type": "external" } ], "gene_names_uniprotkb": "Slc25a39; D11Ertd333e", "gene_names_refseq": "3010027G13Rik; D11Ertd333e; Slc25a39", "protein_names_uniprotkb": "Mitochondrial glutathione transporter SLC25A39; Solute carrier family 25 member 39", "protein_names_refseq": "mitochondrial glutathione transporter SLC25A39; probable mitochondrial glutathione transporter SLC25A39", "tax_id": 10090, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (mmu:68066)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19656490;21750661;25428506;31219806;34428180;34707288", "class_list": "", "function": "Mitochondrial transporter required for glutathione import into mitochondria (PubMed:34707288). Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (PubMed:34707288)., [UniProtKB, PubMed, UniProtKB]; Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis., [RefSeq, PubMed]; SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTM8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0034634 glutathione transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0071281 cellular response to iron ion;GO:0006783 heme biosynthetic process;GO:1990542 mitochondrial transmembrane transport;GO:0160007 glutathione import into mitochondrion;GO:0072753 cellular response to glutathione", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D8K8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TR4-1", "uniprot_id": [ { "id": "SLIT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TR4", "type": "external" } ], "mass": 167420.0, "length": 1531, "protein_name": "Slit homolog 1 protein", "gene_name": "Slit1", "organism": "Mouse", "refseq_name": "slit homolog 1 protein precursor", "refseq_ac": [ { "id": "NP_056563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056563", "type": "external" } ], "gene_names_uniprotkb": "Slit1; Kiaa0813", "gene_names_refseq": "Slil1; Slit1; mKIAA0813", "protein_names_uniprotkb": "Slit homolog 1 protein; Slit-1", "protein_names_refseq": "slit homolog 1 protein precursor; slit homolog 1 protein; slit-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20562)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10433822;10864955;11804571;12097499;21750661;34428180;38943353", "class_list": "", "function": "Slit1 inhibits ovarian follicle development and female fertility in micedagger., [RefSeq, PubMed]; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVB5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0005509 calcium ion binding;GO:0048495 Roundabout binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0007409 axonogenesis;GO:0021510 spinal cord development;GO:0048812 neuron projection morphogenesis;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q80TR4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY18-1", "uniprot_id": [ { "id": "SNX7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY18", "type": "external" } ], "mass": 45000.0, "length": 387, "protein_name": "Sorting nexin-7", "gene_name": "Snx7", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snx7", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "17242355;21750661;28528544;31219806;31599954;34428180", "class_list": "", "function": "Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with SNX4, involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0015031 protein transport;GO:0000423 mitophagy;GO:0032456 endocytic recycling;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CY18-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88632-1", "uniprot_id": [ { "id": "SEM3F_MOUSE", "url": "https://www.uniprot.org/uniprot/O88632", "type": "external" } ], "mass": 88549.0, "length": 785, "protein_name": "Semaphorin-3F", "gene_name": "Sema3f", "organism": "Mouse", "refseq_name": "semaphorin-3F isoform 1 precursor", "refseq_ac": [ { "id": "NP_001298080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298080", "type": "external" } ], "gene_names_uniprotkb": "Sema3f", "gene_names_refseq": "Sema3f; Sema4; Semak", "protein_names_uniprotkb": "Semaphorin-3F; Sema IV; Semaphorin IV", "protein_names_refseq": "semaphorin IV; semaphorin-3F isoform 1 precursor; semaphorin-3F", "tax_id": 10090, "disease": "", "pathway": " (mmu:20350)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;28011936;39927985;9875739", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QNC5;O88633", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O88632-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDQ1-1", "uniprot_id": [ { "id": "PTGR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDQ1", "type": "external" } ], "mass": 38015.0, "length": 351, "protein_name": "Prostaglandin reductase 2", "gene_name": "Ptgr2", "organism": "Mouse", "refseq_name": "prostaglandin reductase 2 isoform 1", "refseq_ac": [ { "id": "NP_001239554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239554", "type": "external" } ], "gene_names_uniprotkb": "Ptgr2; Zadh1", "gene_names_refseq": "1810016I24Rik; 9130222H03Rik; 9630002F03Rik; B830026H24Rik; PGR-2; PRG-2; Ptgr2; Zadh1", "protein_names_uniprotkb": "Prostaglandin reductase 2; 1.3.1.48; 15-oxoprostaglandin 13-reductase; PRG-2; Zinc-binding alcohol dehydrogenase domain-containing protein 1", "protein_names_refseq": "15-oxoprostaglandin 13-reductase; prostaglandin reductase 2 isoform 1; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77219)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15229897;17449869;19000823;21750661;31219806;31616917", "class_list": "", "function": "15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2, [RefSeq, PubMed]; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation., [UniProtKB, PubMed]; This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG36;Q3ULY3;Q8BZA2;Q9D1W8", "ec_number_list": [ { "id": "1.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48", "type": "external" }, { "id": "1.3.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74", "type": "external" } ], "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VDQ1-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCD2-1", "uniprot_id": [ { "id": "SYF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCD2", "type": "external" } ], "mass": 99988.0, "length": 855, "protein_name": "Pre-mRNA-splicing factor SYF1", "gene_name": "Xab2", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor SYF1", "refseq_ac": [ { "id": "NP_080432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080432", "type": "external" } ], "gene_names_uniprotkb": "Xab2; Syf1", "gene_names_refseq": "0610041O14Rik; Xab2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SYF1; XPA-binding protein 2", "protein_names_refseq": "pre-mRNA-splicing factor SYF1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67439); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-72163)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "15725628;21750661;25428506;30084848;34039990;39627609", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing., [UniProtKB, UniProtKB]; The splicing factor XAB2 interacts with ERCC1-XPF and XPG for R-loop processing. Publication Status: Online-Only, [RefSeq, PubMed]; XAB2 has an essential function in mouse embryogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDT5;Q9CVD8", "ec_number_list": [], "go_molecular_function": "GO:0000155 phosphorelay sensor kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0006351 DNA-templated transcription;GO:0021987 cerebral cortex development;GO:0000398 mRNA splicing, via spliceosome;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DCD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPL0-1", "uniprot_id": [ { "id": "SC31A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPL0", "type": "external" } ], "mass": 133569.0, "length": 1230, "protein_name": "Protein transport protein Sec31A", "gene_name": "Sec31a", "organism": "Mouse", "refseq_name": "protein transport protein Sec31A isoform b", "refseq_ac": [ { "id": "NP_081245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081245", "type": "external" } ], "gene_names_uniprotkb": "Sec31a; Sec31l1", "gene_names_refseq": "1810024J13Rik; ABP125; ABP130; HSPC275; Sec31a; Sec31l1", "protein_names_uniprotkb": "Protein transport protein Sec31A; SEC31-like protein 1; SEC31-related protein A", "protein_names_refseq": "SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; Sec31 homolog A; protein transport protein Sec31A isoform b; protein transport protein Sec31A", "tax_id": 10090, "disease": "Halperin-Birk syndrome (Disease Ontology:DOID:0070539)", "pathway": " (mmu:69162); (R-MMU-204005); (R-MMU-2132295); (R-MMU-983170)", "pathway_count": 4, "publication_count": 22, "publication_id_list": "17242355;18630941;19131326;21183079;21750661;24129315;25201882;25605945;28315936;28528544;29187734;30059200;31219806;32782141;34203471;34428180;34887587;36064721;37453647;37507081;38400880;39627609", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UYH3;Q6IQZ3;Q7TQJ7;Q811J4", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0015031 protein transport;GO:0051592 response to calcium ion;GO:0007029 endoplasmic reticulum organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q3UPL0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70336-1", "uniprot_id": [ { "id": "ROCK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70336", "type": "external" } ], "mass": 160586.0, "length": 1388, "protein_name": "Rho-associated protein kinase 2", "gene_name": "Rock2", "organism": "Mouse", "refseq_name": "rho-associated protein kinase 2", "refseq_ac": [ { "id": "NP_033098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033098", "type": "external" } ], "gene_names_uniprotkb": "Rock2", "gene_names_refseq": "B230113H15Rik; ROKalpha; Rho-kinase; Rock-II; Rock2m; Rock2; mKIAA0619", "protein_names_uniprotkb": "Rho-associated protein kinase 2; 2.7.11.39; ROCK-II; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; p164 ROCK-2", "protein_names_refseq": "Rho-associated coiled-coil forming kinage 2; p164 ROCK-2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II", "tax_id": 10090, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236)", "pathway": " (mmu:19878); (R-MMU-3928662); (R-MMU-416482); (R-MMU-416572); (R-MMU-4420097); (R-MMU-5627117); (R-MMU-8980692); (R-MMU-9013026); (R-MMU-9013106); (R-MMU-9013407); (R-MMU-9013422)", "pathway_count": 11, "publication_count": 18, "publication_id_list": "12832488;15699075;15753128;17606625;18718479;19181962;20697158;21183079;21750661;23172836;28089576;30084848;30779550;30862896;30899004;34428180;38775730;8772201", "class_list": "", "function": "MiR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's disease models., [RefSeq, PubMed]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity., [UniProtKB, UniProtKB]; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 6, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5XDA7;Q8BR64;Q8CBR0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" } ], "go_molecular_function": "GO:0072518 Rho-dependent protein serine/threonine kinase activity;GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0032723 positive regulation of connective tissue growth factor production;GO:0071559 response to transforming growth factor beta;GO:1902966 positive regulation of protein localization to early endosome;GO:1905205 positive regulation of connective tissue replacement;GO:1903140 regulation of establishment of endothelial barrier", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P70336-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ASZ8-1", "uniprot_id": [ { "id": "SCMC2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ASZ8", "type": "external" } ], "mass": 52621.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A25", "gene_name": "Slc25a25", "organism": "Mouse", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2", "refseq_ac": [ { "id": "NP_001157829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157829", "type": "external" } ], "gene_names_uniprotkb": "Slc25a25; Kiaa1896; Scamc2", "gene_names_refseq": "1110030N17Rik; MCSC; SCaMC-2; Slc25a25; mKIAA1896", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A25; SCaMC-2; Short calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial Ca2+-dependent solute carrier; mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2; mitochondrial adenyl nucleotide antiporter SLC25A25; short calcium-binding mitochondrial carrier protein 2; small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 member 25", "tax_id": 10090, "disease": "", "pathway": " (mmu:227731)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;15054102;21296886;21750661;28588221;30080851;34428180", "class_list": "", "function": "Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity (PubMed:21296886, PubMed:30080851). Could have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity (PubMed:30080851). Required for left-right pattern specification (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress., [RefSeq, PubMed]; These findings suggest that KD feeding induces expression of the muscle circadian gene Slc25a25 via neural pathways, and that SLC25A25 might be involved in muscle thermogenesis under KD-induced hypothermia in mammals. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ASZ1;A2ASZ5;A2ASZ9;Q6NXM8;Q80T78;Q8BHG0;Q8JZT8;Q8VBT4;Q99KD3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0032094 response to food;GO:0035264 multicellular organism growth;GO:0014823 response to activity;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2ASZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BCZ4-1", "uniprot_id": [ { "id": "SELS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9BCZ4", "type": "external" } ], "mass": 21509.0, "length": 190, "protein_name": "Selenoprotein S", "gene_name": "Selenos", "organism": "Mouse", "refseq_name": "selenoprotein S isoform 2", "refseq_ac": [ { "id": "NP_001335175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335175", "type": "external" } ], "gene_names_uniprotkb": "Selenos; H47; Vimp", "gene_names_refseq": "1500011E07Rik; H-47; H-4; H47; H4; Selenos; Sels; Seps1; Vimp", "protein_names_uniprotkb": "Selenoprotein S; Minor histocompatibility antigen H47; SelS", "protein_names_refseq": "VCP-interacting membrane protein; minor histocompatibility antigen H47; selenoprotein S isoform 2", "tax_id": 10090, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199)", "pathway": " (mmu:109815)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11254699;17210132;18498015;21750661;25009997;31219806;31846435;32186893;38964025", "class_list": "", "function": "Impaired exercise performance with Seps1 reduction or deletion cannot be attributed to heightened cellular stress or inflammation, but it may potentially be mediated, in part, by the effects of Seps1 on the microvasculature., [RefSeq, PubMed]; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Low expression of selenoprotein S induces oxidative damage in cartilages., [RefSeq, PubMed]; Selenoprotein S regulates adipogenesis through IRE1alpha-XBP1 pathway., [RefSeq, PubMed]; These findings suggest that SEPS1 could be a new ER stress-dependent survival factor that protects macrophage against ER stress-induced cellular dysfunction., [RefSeq, PubMed]; This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]., [RefSeq]; We found that suppression of SEPS1 by small interfering RNA severely increases astrocyte injure caused by OGD, suggesting that selenoprotein S protects astrocytes against ischemia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921S1;Q9DB55", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0051117 ATPase binding;GO:0016209 antioxidant activity;GO:1990381 ubiquitin-specific protease binding", "go_cellular_component": "GO:0036502 Derlin-1-VIMP complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0034361 very-low-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0051775 response to redox state;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0050728 negative regulation of inflammatory response;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9BCZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEE0-1", "uniprot_id": [ { "id": "RPE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEE0", "type": "external" } ], "mass": 24945.0, "length": 228, "protein_name": "Ribulose-phosphate 3-epimerase", "gene_name": "Rpe", "organism": "Mouse", "refseq_name": "ribulose-phosphate 3-epimerase isoform 1", "refseq_ac": [ { "id": "NP_001297571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297571", "type": "external" } ], "gene_names_uniprotkb": "Rpe", "gene_names_refseq": "2810429B02Rik; 5730518J08Rik; Rpe", "protein_names_uniprotkb": "Ribulose-phosphate 3-epimerase; 5.1.3.1; Ribulose-5-phosphate-epimerase", "protein_names_refseq": "ribulose-5-phosphate-epimerase; ribulose-phosphate 3-epimerase isoform 1; ribulose-phosphate 3-epimerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:66646); (R-MMU-71336)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;31219806;37828378", "class_list": "", "function": "Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C130;Q9BSB5;Q9CQZ3", "ec_number_list": [ { "id": "5.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.1", "type": "external" } ], "go_molecular_function": "GO:0004750 D-ribulose-phosphate 3-epimerase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VEE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40694-1", "uniprot_id": [ { "id": "SMBP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P40694", "type": "external" } ], "mass": 109466.0, "length": 993, "protein_name": "DNA-binding protein SMUBP-2", "gene_name": "Ighmbp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ighmbp2; Smbp-2; Smbp2", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-binding protein SMUBP-2; 5.6.2.3; 5.6.2.5; ATP-dependent helicase IGHMBP2; CATF1; Cardiac transcription factor 1; DNA and RNA 5'-3' helicase IGHMBP2; Immunoglobulin mu-binding protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "Charcot-Marie-Tooth disease axonal type 2S (Disease Ontology:DOID:0110171); autosomal recessive distal hereditary motor neuronopathy 1 (Disease Ontology:DOID:0111064)", "pathway": " (mmu:20589)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19158098;19299493;21183079;21750661;22965130;30084848;31219806;8493094", "class_list": "", "function": "5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (PubMed:22965130, PubMed:8493094). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (PubMed:8493094). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (PubMed:19158098, PubMed:19299493). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr (PubMed:19299493)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. Specific to 5'-phosphorylated single-stranded guanine-rich sequences. May play a role in RNA metabolism, ribosome biogenesis or initiation of translation. May play a role in regulation of transcription. Interacts with tRNA-Tyr., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:1990955 G-rich single-stranded DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0050905 neuromuscular process;GO:0006974 DNA damage response;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P40694-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIM1-1", "uniprot_id": [ { "id": "S29A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIM1", "type": "external" } ], "mass": 50192.0, "length": 460, "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "Slc29a1", "organism": "Mouse", "refseq_name": "equilibrative nucleoside transporter 1 isoform 1", "refseq_ac": [ { "id": "NP_001186042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186042", "type": "external" } ], "gene_names_uniprotkb": "Slc29a1; Ent1", "gene_names_refseq": "1200014D21Rik; ENT1; Slc29a1; mENT1", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 1; Equilibrative NBMPR-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1; mENT1", "protein_names_refseq": "NBMPR-sensitive equilibrative nucleoside transporter; equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; equilibrative nucleoside transporter 1 isoform 1; nucleoside transporter, es-type; solute carrier family 29 member 1", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); brain ischemia (Disease Ontology:DOID:2316); diffuse idiopathic skeletal hyperostosis (Disease Ontology:DOID:6652)", "pathway": " (mmu:63959); (R-MMU-83936); (R-MMU-9748787); (R-MMU-9755088)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10.1101/2023.09.13.557529;11027664;11085929;11179696;12062437;18299400;19349973;20173027;21750661;21952136;23639800;25428506;25605945;30084848;30779550;31219806;34428180;35790189;36210013;37288658;37725437", "class_list": "", "function": "Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model., [RefSeq, PubMed]; PKC delta/epsilon-dependent stimulation of hENT1 transport by a mechanism that may involve activation of transporters at the membrane possibly by post-translational modification of the protein., [RefSeq, PubMed]; Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:11085929, PubMed:35790189). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:11085929, PubMed:23639800, PubMed:35790189). Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9630, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99K84;Q9DBT8;Q9JHF0", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity;GO:0015207 adenine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9JIM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MB7-1", "uniprot_id": [ { "id": "RN141_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MB7", "type": "external" } ], "mass": 25529.0, "length": 230, "protein_name": "RING finger protein 141", "gene_name": "Rnf141", "organism": "Mouse", "refseq_name": "RING finger protein 141 isoform 1", "refseq_ac": [ { "id": "NP_080275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080275", "type": "external" } ], "gene_names_uniprotkb": "Rnf141; Znf230", "gene_names_refseq": "2610110L04Rik; Rnf141; ZFP36; ZNF230", "protein_names_uniprotkb": "RING finger protein 141; Zinc finger protein 230", "protein_names_refseq": "RING finger protein 141 isoform 1; zinc finger protein 230", "tax_id": 10090, "disease": "", "pathway": " (mmu:67150)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12804569;18823591;21750661;23196134;34428180;37828378", "class_list": "", "function": "In summary, a potential exon structure in the targeting vector sequence involved in the expression of targeting Znf230 gene and disturbed the strategy of this gene-targeting experiment., [RefSeq, PubMed]; May be involved in spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; May function as a testis specific transcription factor during mouse spermatogenesis, [RefSeq, PubMed]; The results indicate that Znf230 may play an important role in mouse spermatogenesis, including spermatogenic cell proliferation and sperm maturation, as well as motility and fertilization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D040;Q9D5C4;Q9D9L0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99MB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT45-1", "uniprot_id": [ { "id": "RRAGD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TT45", "type": "external" } ], "mass": 51232.0, "length": 449, "protein_name": "Ras-related GTP-binding protein D", "gene_name": "Rragd", "organism": "Mouse", "refseq_name": "ras-related GTP-binding protein D isoform 2", "refseq_ac": [ { "id": "NP_081767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081767", "type": "external" } ], "gene_names_uniprotkb": "Rragd; Ragd", "gene_names_refseq": "5730543C08Rik; C030003H22Rik; D4Ertd174e; Rragd", "protein_names_uniprotkb": "Ras-related GTP-binding protein D; 3.6.5.-; Rag D; RagD", "protein_names_refseq": "rag D; ragD; ras-related GTP-binding protein D isoform 2; ras-related GTP-binding protein D", "tax_id": 10090, "disease": "follicular lymphoma (Disease Ontology:DOID:0050873); renal hypomagnesemia 7, with or without dilated cardiomyopathy (Disease Ontology:DOID:0060972); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:52187); (R-MMU-1632852); (R-MMU-165159); (R-MMU-166208); (R-MMU-380972); (R-MMU-5628897); (R-MMU-8943724); (R-MMU-9639288)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "21750661;22645316;25259925;30595499;33300544;33883257;34607910", "class_list": "", "function": "Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity., [RefSeq, PubMed]; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GTT2;Q9CYC2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046982 protein heterodimerization activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0010507 negative regulation of autophagy;GO:0009267 cellular response to starvation;GO:1990253 cellular response to leucine starvation;GO:0071233 cellular response to L-leucine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7TT45-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K386-1", "uniprot_id": [ { "id": "RAB15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K386", "type": "external" } ], "mass": 24318.0, "length": 212, "protein_name": "Ras-related protein Rab-15", "gene_name": "Rab15", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab15", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-15; 3.6.5.2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:104886); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB15 may act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:1903307 positive regulation of regulated secretory pathway;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K386-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70338-1", "uniprot_id": [ { "id": "RNH1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70338", "type": "external" } ], "mass": 31805.0, "length": 285, "protein_name": "Ribonuclease H1", "gene_name": "Rnaseh1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnaseh1; Rnh1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonuclease H1; 3.1.26.4; RNase H1", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111515)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "21750661;9799596", "class_list": "", "function": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VCR6", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70338-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1ARI9-1", "uniprot_id": [ { "id": "PRR29_MOUSE", "url": "https://www.uniprot.org/uniprot/B1ARI9", "type": "external" } ], "mass": 20763.0, "length": 187, "protein_name": "Proline-rich protein 29", "gene_name": "Prr29", "organism": "Mouse", "refseq_name": "proline-rich protein 29", "refseq_ac": [ { "id": "NP_083621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083621", "type": "external" } ], "gene_names_uniprotkb": "Prr29; 2310007L24Rik", "gene_names_refseq": "2310007L24Rik; Prr29", "protein_names_uniprotkb": "Proline-rich protein 29", "protein_names_refseq": "proline-rich protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:75573)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7I4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1ARI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YR7-1", "uniprot_id": [ { "id": "PRP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YR7", "type": "external" } ], "mass": 106722.0, "length": 941, "protein_name": "Pre-mRNA-processing factor 6", "gene_name": "Prpf6", "organism": "Mouse", "refseq_name": "pre-mRNA-processing factor 6", "refseq_ac": [ { "id": "NP_598462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598462", "type": "external" } ], "gene_names_uniprotkb": "Prpf6", "gene_names_refseq": "1190003A07Rik; 2610031L17Rik; ANT-1; Prpf6; U5-102K", "protein_names_uniprotkb": "Pre-mRNA-processing factor 6; PRP6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein", "protein_names_refseq": "PRP6 homolog; PRP6 pre-mRNA splicing factor 6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein; pre-mRNA-processing factor 6", "tax_id": 10090, "disease": "retinitis pigmentosa 60 (Disease Ontology:DOID:0110411)", "pathway": " (mmu:68879); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "16414017;20173027;21183079;21750661;25428506;25428507;25605945;30084848;30779550;34428180;39627609", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation., [UniProtKB, UniProtKB]; The existence of these functional domains may further support the idea that ANT-1 can function as an AR-AF-1-specific coactivator while mediating a transcription-splicing coupling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULJ7;Q542P0;Q8CIK9;Q8R3M8;Q99JN1;Q9CSZ0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0006403 RNA localization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91YR7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CI78-1", "uniprot_id": [ { "id": "RMND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CI78", "type": "external" } ], "mass": 51843.0, "length": 450, "protein_name": "Required for meiotic nuclear division protein 1 homolog", "gene_name": "Rmnd1", "organism": "Mouse", "refseq_name": "required for meiotic nuclear division protein 1 homolog isoform a", "refseq_ac": [ { "id": "NP_079619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079619", "type": "external" } ], "gene_names_uniprotkb": "Rmnd1", "gene_names_refseq": "0610042C05Rik; Rmnd1", "protein_names_uniprotkb": "Required for meiotic nuclear division protein 1 homolog", "protein_names_refseq": "required for meiotic nuclear division protein 1 homolog isoform a; required for meiotic nuclear division protein 1 homolog", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 11 (Disease Ontology:DOID:0111481)", "pathway": " (mmu:66084)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;22872234;31219806", "class_list": "", "function": "Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQK1;Q8BW19;Q8R2S0;Q8VCK4;Q9CV49;Q9CVN0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CI78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62052-1", "uniprot_id": [ { "id": "P_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62052", "type": "external" } ], "mass": 91869.0, "length": 833, "protein_name": "P protein", "gene_name": "Oca2", "organism": "Mouse", "refseq_name": "P protein", "refseq_ac": [ { "id": "NP_068679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068679", "type": "external" } ], "gene_names_uniprotkb": "Oca2; P", "gene_names_refseq": "D7H15S12; D7Icr28RN; D7Nic1; Oca2; p; p", "protein_names_uniprotkb": "P protein; Melanocyte-specific transporter protein; Pink-eyed dilution protein", "protein_names_refseq": "P protein; melanocyte-specific transporter protein; pink-eyed dilution protein", "tax_id": 10090, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); oculocutaneous albinism type II (Disease Ontology:DOID:0070096); pigmentation disease (Disease Ontology:DOID:10123); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513); actinic keratosis (Disease Ontology:DOID:8866); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (mmu:18431); (R-MMU-5662702)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11310796;11601658;12058062;12475946;1509264;21750661;28009282;7991586", "class_list": "", "function": "Contributes to a melanosome-specific anion (chloride) current that modulates melanosomal pH for optimal tyrosinase activity required for melanogenesis and the melanosome maturation. One of the components of the mammalian pigmentary system (By similarity). May serve as a key control point at which color variation is determined. Major determinant of eye color (Probable). Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis (PubMed:12058062)., [UniProtKB, PubMed, UniProtKB, PubMed]; These results suggest that impairment in GABRB3 downregulates OCA2 and indirectly causes ocular hypopigmentation and visual defects in Angelman syndrome (AS) and Prader-Willi syndrome, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBP9", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0033162 melanosome membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0007286 spermatid development;GO:0043473 pigmentation;GO:0042438 melanin biosynthetic process;GO:0048066 developmental pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62052-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1C9-1", "uniprot_id": [ { "id": "RRP7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1C9", "type": "external" } ], "mass": 32399.0, "length": 280, "protein_name": "Ribosomal RNA-processing protein 7 homolog A", "gene_name": "Rrp7a", "organism": "Mouse", "refseq_name": "ribosomal RNA-processing protein 7 homolog A isoform 1", "refseq_ac": [ { "id": "NP_083377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083377", "type": "external" } ], "gene_names_uniprotkb": "Rrp7a", "gene_names_refseq": "1110014J01Rik; Kheg1; Rrp7a", "protein_names_uniprotkb": "Ribosomal RNA-processing protein 7 homolog A; Gastric cancer antigen Zg14 homolog", "protein_names_refseq": "gastric cancer antigen Zg14 homolog; kidney highly expressed protein 1; ribosomal RNA-processing protein 7 homolog A isoform 1; ribosomal RNA-processing protein 7 homolog A", "tax_id": 10090, "disease": "primary autosomal recessive microcephaly 28 (Disease Ontology:DOID:0051039); primary microcephaly (Disease Ontology:DOID:0070297)", "pathway": " (mmu:74778); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;23211737;34428180", "class_list": "", "function": "Nucleolar protein that is involved in ribosomal RNA (rRNA) processing. Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rrp7a is required for the blastocyst formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TWT8;Q8CCK8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005929 cilium", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0001825 blastocyst formation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14BX2-1", "uniprot_id": [ { "id": "PRS55_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14BX2", "type": "external" } ], "mass": 36087.0, "length": 321, "protein_name": "Serine protease 55", "gene_name": "Prss55", "organism": "Mouse", "refseq_name": "serine protease 55 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001074532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074532", "type": "external" } ], "gene_names_uniprotkb": "Prss55", "gene_names_refseq": "4933401F05Rik; Prss55", "protein_names_uniprotkb": "Serine protease 55; 3.4.21.-", "protein_names_refseq": "probable serine protease UNQ9391/PRO34284 homolog; protease, serine 55; serine protease 55 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71037)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;29563520;30032357;32301961;33417308", "class_list": "", "function": "Data show that serine protease 55 (PRSS55) plays vital roles in regulating male fertility including in vivo sperm migration and in vitro sperm-egg interaction, [RefSeq, PubMed]; PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice., [RefSeq, PubMed]; Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction (PubMed:30032357)., [UniProtKB, PubMed]; Prss55 but not Prss51 is required for male fertility in micedagger., [RefSeq, PubMed]; Study of the mouse Tex37 and Prss55 - genes evolutionarily conserved in eutherians (including human) found that these genes had a testis-enriched expression pattern in mice, but they are not individually essential for spermatogenesis, testis development and male fertility in mice in laboratory conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3X9K6", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0016485 protein processing;GO:0030317 flagellated sperm motility;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q14BX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UIW5-1", "uniprot_id": [ { "id": "RNF10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UIW5", "type": "external" } ], "mass": 88345.0, "length": 804, "protein_name": "E3 ubiquitin-protein ligase RNF10", "gene_name": "Rnf10", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF10 isoform 1", "refseq_ac": [ { "id": "NP_001289377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289377", "type": "external" } ], "gene_names_uniprotkb": "Rnf10; Kiaa0262; Rie2; Sid2705", "gene_names_refseq": "RIE2; Rnf10; mKIAA0262", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF10; 2.3.2.27; RING finger protein 10; Sid 2705", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF10 isoform 1; E3 ubiquitin-protein ligase RNF10; sid 2705", "tax_id": 10090, "disease": "", "pathway": " (mmu:50849)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10697961;21750661;23526782;25428506;25605945;27802388;30084848;30779550;31219806;31599954;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling. Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation. The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. The action of RNF10 in iRQC is counteracted by USP10., [UniProtKB, UniProtKB]; Results showed that increase in Rnf10 expression upon RA induction is necessary for the positive regulation of cyclin kinase inhibitor p21 expression, which leads to cell cycle arrest and is critical for neuronal differentiation., [RefSeq, PubMed]; The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDS8;Q6ZQE8;Q91YZ9;Q9R0P0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070651 nonfunctional rRNA decay;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3UIW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59279-1", "uniprot_id": [ { "id": "RAB2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P59279", "type": "external" } ], "mass": 24198.0, "length": 216, "protein_name": "Ras-related protein Rab-2B", "gene_name": "Rab2b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-2B", "refseq_ac": [ { "id": "NP_766189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766189", "type": "external" } ], "gene_names_uniprotkb": "Rab2b", "gene_names_refseq": "1500012D09Rik; 4930528G15Rik; A230002G14; D530043M21Rik; Rab2b", "protein_names_uniprotkb": "Ras-related protein Rab-2B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:76338); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25605945;28063257;28930687;34714330", "class_list": "", "function": "The RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states (PubMed:28930687). In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:28930687). Regulates the compacted morphology of the Golgi (By similarity). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (PubMed:28930687). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28063257)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TV67", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P59279-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMZ5-1", "uniprot_id": [ { "id": "SEN34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMZ5", "type": "external" } ], "mass": 34196.0, "length": 316, "protein_name": "tRNA-splicing endonuclease subunit Sen34", "gene_name": "Tsen34", "organism": "Mouse", "refseq_name": "tRNA-splicing endonuclease subunit Sen34 isoform a", "refseq_ac": [ { "id": "NP_001157676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157676", "type": "external" } ], "gene_names_uniprotkb": "Tsen34; Leng5; Sen34", "gene_names_refseq": "0610027F08Rik; Leng5; Tsen34", "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen34; 4.6.1.16; Leukocyte receptor cluster member 5 homolog; tRNA-intron endonuclease Sen34", "protein_names_refseq": "leukocyte receptor cluster (LRC) member 5; leukocyte receptor cluster member 5 homolog; tRNA splicing endonuclease 34 homolog; tRNA-intron endonuclease Sen34; tRNA-splicing endonuclease subunit Sen34 isoform a; tRNA-splicing endonuclease subunit Sen34", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 2C (Disease Ontology:DOID:0060269)", "pathway": " (mmu:66078)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;40885482", "class_list": "", "function": "Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q58EU2;Q99LV6;Q9CYW1", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0000213 tRNA-intron lyase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000214 tRNA-intron endonuclease complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BMZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921R7-1", "uniprot_id": [ { "id": "S35A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921R7", "type": "external" } ], "mass": 50115.0, "length": 437, "protein_name": "UDP-sugar transporter protein SLC35A5", "gene_name": "Slc35a5", "organism": "Mouse", "refseq_name": "UDP-sugar transporter protein SLC35A5 isoform 1", "refseq_ac": [ { "id": "NP_083032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083032", "type": "external" } ], "gene_names_uniprotkb": "Slc35a5", "gene_names_refseq": "1010001J06Rik; D16Ertd450e; D730043G07Rik; Slc35a5", "protein_names_uniprotkb": "UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5", "protein_names_refseq": "UDP-sugar transporter protein SLC35A5 isoform 1; probable UDP-sugar transporter protein SLC35A5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74102)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19144319;21183079;21750661;36210013", "class_list": "glycogene", "function": "Probable UDP-sugar:UMP transmembrane antiporter involved in UDP-alpha-D-glucuronate/UDP-GlcA, UDP-GlcNAc/UDP-N-acetyl-alpha-D-glucosamine and UDP-N-acetyl-alpha-D-galactosamine/UDP-GalNAc transport from the cytosol to the lumen of the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 12, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC72", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921R7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TE0-1", "uniprot_id": [ { "id": "RPAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TE0", "type": "external" } ], "mass": 155270.0, "length": 1409, "protein_name": "RNA polymerase II-associated protein 1", "gene_name": "Rpap1", "organism": "Mouse", "refseq_name": "RNA polymerase II-associated protein 1", "refseq_ac": [ { "id": "NP_001157173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157173", "type": "external" } ], "gene_names_uniprotkb": "Rpap1; Kiaa1403", "gene_names_refseq": "1190005L06Rik; A730023M06Rik; Rpap1; mKIAA1403", "protein_names_uniprotkb": "RNA polymerase II-associated protein 1", "protein_names_refseq": "RNA polymerase II-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68925)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15345747;21750661;25428506;31219806;32152506", "class_list": "", "function": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ24;Q148U0;Q148U1;Q3TJ48;Q3TLZ5;Q3TTA6;Q80UT8;Q91VM0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030880 RNA polymerase complex;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80TE0-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5R4-1", "uniprot_id": [ { "id": "SPAT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5R4", "type": "external" } ], "mass": 51077.0, "length": 444, "protein_name": "Spermatogenesis-associated protein 1", "gene_name": "Spata1", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001303685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303685", "type": "external" } ], "gene_names_uniprotkb": "Spata1", "gene_names_refseq": "4921536I21Rik; SP-2; Spata1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 1", "protein_names_refseq": "spermatogenesis-associated protein 1 isoform 1; spermatogenesis-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70951)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31816150", "class_list": "", "function": "Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EI96;Q7TPN4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D5R4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0E7-1", "uniprot_id": [ { "id": "SERC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0E7", "type": "external" } ], "mass": 50478.0, "length": 450, "protein_name": "Serine incorporator 2", "gene_name": "Serinc2", "organism": "Mouse", "refseq_name": "serine incorporator 2 isoform 1", "refseq_ac": [ { "id": "NP_766290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766290", "type": "external" } ], "gene_names_uniprotkb": "Serinc2; Tde2l", "gene_names_refseq": "2310004K20Rik; FKSG84; Serinc2; TDE2; Tde2l", "protein_names_uniprotkb": "Serine incorporator 2; Tumor differentially expressed protein 2-like", "protein_names_refseq": "serine incorporator 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230779); (R-MMU-977347)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. In contrast to SERINC3 and SERINC5, has no effect on gammaretrovirus particles infectivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K0E7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTN6-1", "uniprot_id": [ { "id": "S22AL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTN6", "type": "external" } ], "mass": 63321.0, "length": 564, "protein_name": "Solute carrier family 22 member 21", "gene_name": "Slc22a21", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 21 isoform 1", "refseq_ac": [ { "id": "NP_062697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062697", "type": "external" } ], "gene_names_uniprotkb": "Slc22a21; Octn3; Slc22a9", "gene_names_refseq": "Octn3; Slc22a21; Slc22a9", "protein_names_uniprotkb": "Solute carrier family 22 member 21; Organic cation/carnitine transporter 3; Solute carrier family 22 member 9", "protein_names_refseq": "organic cation/carnitine transporter 3; solute carrier family 22 (organic cation transporter), member 9; solute carrier family 22 member 21 isoform 1; solute carrier family 22 member 21", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); systemic primary carnitine deficiency disease (Disease Ontology:DOID:14365); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congestive heart failure (Disease Ontology:DOID:6000); inherited metabolic disorder (Disease Ontology:DOID:655); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (mmu:56517)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11010964;12535646;15389639;16288981;19233567;20112288;21750661;30059200;32070725", "class_list": "", "function": "Demonstration of expression and colocalization of Octn3 and catalase in liver peroxisomes, [RefSeq, PubMed]; Octn1, -2, and -3 are expressed in many regions of murine heart, [RefSeq, PubMed]; Results demonstrate that mammalian small intestine expresses OCTN3 mRNA along the villus and that OCTN3 protein is located in the basolateral membrane., [RefSeq, PubMed]; Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746., [UniProtKB, PubMed]; There was a significant upregulation of mOctn1 and mOctn2 mRNA by qRT-PCR in mdx quadriceps and of mOctn2 and mOctn3 mRNA in mdx heart, [RefSeq, PubMed]; This is the first report showing a functional apical OCTN2 in the renal medulla and a functional apical OCTN3 in both renal cortex and medulla., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5SWV0", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0009609 response to symbiotic bacterium;GO:0006811 monoatomic ion transport;GO:0034612 response to tumor necrosis factor;GO:0060731 positive regulation of intestinal epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9WTN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLI6-1", "uniprot_id": [ { "id": "SCLY_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLI6", "type": "external" } ], "mass": 47174.0, "length": 432, "protein_name": "Selenocysteine lyase", "gene_name": "Scly", "organism": "Mouse", "refseq_name": "selenocysteine lyase", "refseq_ac": [ { "id": "NP_057926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057926", "type": "external" } ], "gene_names_uniprotkb": "Scly; Scl", "gene_names_refseq": "A930015N15Rik; SCL; Scly1; Scly2; Scly; mSCL", "protein_names_uniprotkb": "Selenocysteine lyase; 4.4.1.16; mSCL", "protein_names_refseq": "Selenocysteine reductase; selenocysteine lyase; selenocysteine reductase", "tax_id": 10090, "disease": "", "pathway": " (mmu:50880); (R-MMU-2408508)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10692412;21750661;22487427;22890841;23811004;24519931;26586820;29385050;31219806;31340540;31717805;34428180", "class_list": "", "function": "Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss of Scly within a neuronal sub-population that makes up a small fraction of the hypothalamus produces a phenotype in mice distinguished by reduced weight gain while on high fat diet and resistance to the development of leptin insensitivity. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely 'unrelated' regenerating protein, Reg3beta, via transcriptional activation of Scly, [RefSeq, PubMed]; Scly knockout mice do not display neurological dysfunction comparable to Sepp1 knockout mice., [RefSeq, PubMed]; Selenocysteine lyase regulates energy metabolism via the hypothalamus. Publication Status: Online-Only, [RefSeq, PubMed]; Studied the role of selenocysteine lyase in amino acid metabolism using knockout mice and a combination of transcriptomics and metabolomics. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggested a dependence of glucose and lipid homeostasis on selenocysteine lyase activity. These findings connect Se and energy metabolism and demonstrate for the first time a unique physiological role of selenocysteine lyase., [RefSeq, PubMed]; These findings provide the first in vivo evidence that Scly and Sepp1 work cooperatively to maintain selenoprotein function in the mammalian brain., [RefSeq, PubMed]; This study showed that Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CB57;Q8CB94", "ec_number_list": [ { "id": "4.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0016597 amino acid binding;GO:0016740 transferase activity;GO:0009000 selenocysteine lyase activity;GO:0070279 vitamin B6 binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032868 response to insulin;GO:0016261 selenocysteine catabolic process;GO:1900408 negative regulation of cellular response to oxidative stress;GO:0001887 selenium compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JLI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61219-1", "uniprot_id": [ { "id": "RPAB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P61219", "type": "external" } ], "mass": 14464.0, "length": 127, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "gene_name": "Polr2f", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC2", "refseq_ac": [ { "id": "NP_081507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081507", "type": "external" } ], "gene_names_uniprotkb": "Polr2f", "gene_names_refseq": "1810060D16Rik; Polr2f; RPB6", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-directed RNA polymerase II subunit F; RNA polymerases I, II, and III subunit ABC2; RPB6 homolog", "protein_names_refseq": "DNA-directed RNA polymerase II subunit F; DNA-directed RNA polymerases I, II, and III subunit RPABC2; RNA Pol II; RNA polymerases I, II, and III subunit ABC2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69833); (R-MMU-112382); (R-MMU-113418); (R-MMU-5250924); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 29, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and together with parts of POLR2A/RPB1 and POLR2B/RPB2 forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61219-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D958-1", "uniprot_id": [ { "id": "SPCS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D958", "type": "external" } ], "mass": 18186.0, "length": 161, "protein_name": "Signal peptidase complex subunit 1", "gene_name": "Spcs1", "organism": "Mouse", "refseq_name": "signal peptidase complex subunit 1", "refseq_ac": [ { "id": "NP_081187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081187", "type": "external" } ], "gene_names_uniprotkb": "Spcs1; Spc12", "gene_names_refseq": "1810004F21Rik; Spcs1", "protein_names_uniprotkb": "Signal peptidase complex subunit 1; Microsomal signal peptidase 12 kDa subunit; SPase 12 kDa subunit", "protein_names_refseq": "SPase 12 kDa subunit; microsomal signal peptidase 12 kDa subunit; signal peptidase complex subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69019); (R-MMU-422085); (R-MMU-9768727)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJM2", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0019082 viral protein processing;GO:0019068 virion assembly;GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D958-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920F6-1", "uniprot_id": [ { "id": "SMC1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q920F6", "type": "external" } ], "mass": 144513.0, "length": 1248, "protein_name": "Structural maintenance of chromosomes protein 1B", "gene_name": "Smc1b", "organism": "Mouse", "refseq_name": "structural maintenance of chromosomes protein 1B", "refseq_ac": [ { "id": "NP_536718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536718", "type": "external" } ], "gene_names_uniprotkb": "Smc1b; Smc1l2", "gene_names_refseq": "SMC-1B; SMC1beta; Smc1b; Smc1l2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 1B; SMC protein 1B; SMC-1-beta; SMC-1B", "protein_names_refseq": "SMC protein 1B; SMC-1-beta; structural maintenace of chromosomes 1B; structural maintenance of chromosomes protein 1B", "tax_id": 10090, "disease": "Cornelia de Lange syndrome 2 (Disease Ontology:DOID:0080506)", "pathway": " (mmu:140557)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11564881;15146193;16236716;21750661;24287868;24788674;35820727", "class_list": "", "function": "E2F6 silences SMC1beta and STAG3 in somatic cells, [RefSeq, PubMed]; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I., [UniProtKB, PubMed, PubMed]; SMC1 beta-deficient mice of both sexes are sterile. Male meiosis is blocked in pachytene; female meiosis is highly error-prone but continues until metaphase II., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051321 meiotic cell cycle;GO:0007062 sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q920F6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D244-1", "uniprot_id": [ { "id": "RNAS6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D244", "type": "external" } ], "mass": 17675.0, "length": 153, "protein_name": "Ribonuclease K6", "gene_name": "Rnase6", "organism": "Mouse", "refseq_name": "ribonuclease K6", "refseq_ac": [ { "id": "NP_084374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084374", "type": "external" } ], "gene_names_uniprotkb": "Rnase6", "gene_names_refseq": "9530043P15Rik; Rnase6", "protein_names_uniprotkb": "Ribonuclease K6; 3.1.27.-; RNase K6", "protein_names_refseq": "RNase K6; ribonuclease A family, member 6; ribonuclease K6", "tax_id": 10090, "disease": "", "pathway": " (mmu:78416); (R-MMU-6803157)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15693621;21750661;25075772;30084848;34428180;38744252", "class_list": "", "function": "Murine Ribonuclease 6 Limits Bacterial Dissemination during Experimental Urinary Tract Infection., [RefSeq, PubMed]; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:15693621). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:15693621, PubMed:25075772). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; The ancestral rodent RNase 6 was subject to accelerated evolution, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2RTT6;Q6QDX5", "ec_number_list": [ { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C551-1", "uniprot_id": [ { "id": "R51A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C551", "type": "external" } ], "mass": 36227.0, "length": 337, "protein_name": "RAD51-associated protein 1", "gene_name": "Rad51ap1", "organism": "Mouse", "refseq_name": "RAD51-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001334384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334384", "type": "external" } ], "gene_names_uniprotkb": "Rad51ap1", "gene_names_refseq": "2510006L10Rik; RAB22; Rad51ap1", "protein_names_uniprotkb": "RAD51-associated protein 1; RAB22", "protein_names_refseq": "RAD51-associated protein 1 isoform 2; RAD51-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19362); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "17242355;21183079;21307306;21750661;34099522;37962862;9192668", "class_list": "", "function": "RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy., [RefSeq, PubMed]; Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination., [UniProtKB, UniProtKB]; The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55219;Q8BP36;Q99L94;Q9D0J0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0000217 DNA secondary structure binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005694 chromosome;GO:0032991 protein-containing complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006310 DNA recombination;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C551-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6TQD1-1", "uniprot_id": [ { "id": "RN212_MOUSE", "url": "https://www.uniprot.org/uniprot/F6TQD1", "type": "external" } ], "mass": 33898.0, "length": 307, "protein_name": "Probable E3 SUMO-protein ligase RNF212", "gene_name": "Rnf212", "organism": "Mouse", "refseq_name": "probable E3 SUMO-protein ligase RNF212", "refseq_ac": [ { "id": "NP_001349816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001349816", "type": "external" } ], "gene_names_uniprotkb": "Rnf212", "gene_names_refseq": "EG330157; F830003B07; Rnf212; repro57", "protein_names_uniprotkb": "Probable E3 SUMO-protein ligase RNF212; 2.3.2.-; Probable E3 SUMO-protein transferase RNF212; RING finger protein 212", "protein_names_refseq": "probable E3 SUMO-protein ligase RNF212; probable E3 SUMO-protein transferase RNF212", "tax_id": 10090, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910); spermatogenic failure 62 (Disease Ontology:DOID:0112351)", "pathway": " (mmu:671564)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;23396135;24390283;25342176", "class_list": "", "function": "Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination., [RefSeq, PubMed]; Mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility., [RefSeq, PubMed]; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination., [UniProtKB, PubMed, PubMed]; We show that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BN46", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0016925 protein sumoylation;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:0006311 meiotic gene conversion;GO:0051026 chiasma assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F6TQD1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WU2-1", "uniprot_id": [ { "id": "S22A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WU2", "type": "external" } ], "mass": 59614.0, "length": 540, "protein_name": "Solute carrier family 22 member 7", "gene_name": "Slc22a7", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 7", "refseq_ac": [ { "id": "NP_659105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659105", "type": "external" } ], "gene_names_uniprotkb": "Slc22a7; Oat2", "gene_names_refseq": "NLT; OAT2; Slc22a7", "protein_names_uniprotkb": "Solute carrier family 22 member 7; Organic anion transporter 2; mOAT2", "protein_names_refseq": "mOAT2; organic anion transporter 2; solute carrier family 22 member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:108114); (R-MMU-561048); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12065749;16256982;16885152;18344607;21750661;30084848;34428180", "class_list": "", "function": "Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:12065749). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:12065749). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides, and nucleotides with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (By similarity). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (By similarity). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (By similarity). Involved in renal secretion and possible reabsorption of creatinine (By similarity). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:12065749). Unlike human hortolog, able to transport glutarate (PubMed:12065749). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (By similarity)., [UniProtKB, PubMed, UniProtKB]; Propionate (3-carbon SCFA) was transported by mOat2 in a time-dependent manner., [RefSeq, PubMed]; Results indicate that mOAT2 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules., [RefSeq, PubMed]; There exists a sex- and species-related differential gene expression of the OAT2 isoform., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNX2;Q8BUQ9;Q8K4S9;Q8R0M7;Q8R125", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015711 organic anion transport;GO:0035634 response to stilbenoid;GO:0043252 sodium-independent organic anion transport;GO:0015742 alpha-ketoglutarate transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63042-1", "uniprot_id": [ { "id": "STMN4_MOUSE", "url": "https://www.uniprot.org/uniprot/P63042", "type": "external" } ], "mass": 22087.0, "length": 189, "protein_name": "Stathmin-4", "gene_name": "Stmn4", "organism": "Mouse", "refseq_name": "stathmin-4 isoform 1", "refseq_ac": [ { "id": "NP_001297451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297451", "type": "external" } ], "gene_names_uniprotkb": "Stmn4", "gene_names_refseq": "Lagl; RB3; Stmn4", "protein_names_uniprotkb": "Stathmin-4; RB3; Stathmin-like protein B3", "protein_names_refseq": "stathmin-4 isoform 1; stathmin-4; stathmin-like protein B3; stathmin-like protein RB3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56471)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17640754;21750661", "class_list": "", "function": "Exhibits microtubule-destabilizing activity., [UniProtKB]; These data indicate that the overexpression of stathmin disrupts dendritic microtubule,organization, motor protein distribution, and neural function in Purkinje cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35414;O35415;O35416", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63042-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925E1-1", "uniprot_id": [ { "id": "SNTG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925E1", "type": "external" } ], "mass": 57982.0, "length": 517, "protein_name": "Gamma-1-syntrophin", "gene_name": "Sntg1", "organism": "Mouse", "refseq_name": "gamma-1-syntrophin isoform 1", "refseq_ac": [ { "id": "NP_001277322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277322", "type": "external" } ], "gene_names_uniprotkb": "Sntg1", "gene_names_refseq": "4933426D16Rik; G1SYN; SYN4; Sntg1", "protein_names_uniprotkb": "Gamma-1-syntrophin; G1SYN; SYN4; Syntrophin-4", "protein_names_refseq": "gamma-1-syntrophin isoform 1; gamma-1-syntrophin; syntrophin-4", "tax_id": 10090, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (mmu:71096)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16857187;21750661", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation (By similarity)., [UniProtKB]; Gamma1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. gamma2-Syntrophin is expressed in many tissues including skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3Z5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0032587 ruffle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q925E1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A7Q9-1", "uniprot_id": [ { "id": "RN19B_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A7Q9", "type": "external" } ], "mass": 78127.0, "length": 732, "protein_name": "E3 ubiquitin-protein ligase RNF19B", "gene_name": "Rnf19b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF19B isoform 1", "refseq_ac": [ { "id": "NP_001355692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001355692", "type": "external" } ], "gene_names_uniprotkb": "Rnf19b; Ibrdc3; Nklam", "gene_names_refseq": "4930534K13Rik; 4930555L03Rik; Ibrdc3; Rnf19b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF19B; 2.3.2.31; IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF19B isoform 1; E3 ubiquitin-protein ligase RNF19B; IBR domain containing 3; IBR domain-containing protein 3; natural killer lytic-associated molecule", "tax_id": 10090, "disease": "", "pathway": " (mmu:75234); (R-MMU-983168); (R-MMU-9958825)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10912506;16075062;19915045;21750661;23085241;25182373;27485036;31539400;34428180", "class_list": "", "function": "Data show that Natural Killer Lytic-Associated Molecule (NKLAM) is a component of macrophage phagosomes and is involved in macrophage bactericidal functions., [RefSeq, PubMed]; E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity)., [UniProtKB, UniProtKB]; Results indicate that natural killer lytic-associated molecule (NKLAM/RNF19b) plays a role in regulating the production of pro-inflammatory cytokines during viral infection. Publication Status: Online-Only, [RefSeq, PubMed]; Support the role for NKLAM in NK function both in vitro and in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AUN9;Q7TT05", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0042267 natural killer cell mediated cytotoxicity;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2A7Q9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG32-1", "uniprot_id": [ { "id": "PSD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG32", "type": "external" } ], "mass": 47437.0, "length": 422, "protein_name": "26S proteasome non-ATPase regulatory subunit 11", "gene_name": "Psmd11", "organism": "Mouse", "refseq_name": "26S proteasome non-ATPase regulatory subunit 11", "refseq_ac": [ { "id": "NP_848731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848731", "type": "external" } ], "gene_names_uniprotkb": "Psmd11", "gene_names_refseq": "1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik; P44.5; Psmd11; S9", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:69077); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-6798695); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;16857966;20665223;21183079;21750661;22009320;25605945;31219806;33517884;34203471;34428180;37507081;39927985;40684658", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity., [UniProtKB, UniProtKB]; Generation and identification of a conditional knockout allele for the PSMD11 gene in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005838 proteasome regulatory particle", "go_biological_process": "GO:0048863 stem cell differentiation;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043248 proteasome assembly;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q8BG32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64008-1", "uniprot_id": [ { "id": "RAB34_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64008", "type": "external" } ], "mass": 29101.0, "length": 259, "protein_name": "Ras-related protein Rab-34", "gene_name": "Rab34", "organism": "Mouse", "refseq_name": "ras-related protein Rab-34", "refseq_ac": [ { "id": "NP_001152954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152954", "type": "external" } ], "gene_names_uniprotkb": "Rab34; Rab39; Rah1; Rah", "gene_names_refseq": "Narr; Rab34; Rah1; Rah", "protein_names_uniprotkb": "Ras-related protein Rab-34; 3.6.5.2; Ras-related homolog; Ras-related protein Rab-39; Ras-related protein Rah", "protein_names_refseq": "RAB34, member of RAS oncogene family; rab-39; ras-related homolog; ras-related protein Rab-34; ras-related protein Rab-39; ras-related protein Rah", "tax_id": 10090, "disease": "orofaciodigital syndrome XX (Disease Ontology:DOID:0060962)", "pathway": " (mmu:19376); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12446704;12475955;1752434;19144319;21183079;21750661;29290584;30301781;33989524;33989527;37828378", "class_list": "", "function": "Association with membrane ruffles and macropinosomes and promotes macropinosome formation, [RefSeq, PubMed]; Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway., [RefSeq, PubMed]; Rab34 is necessary for early stages of intracellular ciliogenesis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:12475955). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Required for the early steps of intracellular ciliogenesis, the cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (PubMed:30301781, PubMed:33989524). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (PubMed:33989524). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHJ0;Q99P59;Q99P90", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0090382 phagosome maturation;GO:0006897 endocytosis;GO:0071333 cellular response to glucose stimulus;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64008-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U2P1-1", "uniprot_id": [ { "id": "SC24A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U2P1", "type": "external" } ], "mass": 118782.0, "length": 1090, "protein_name": "Protein transport protein Sec24A", "gene_name": "Sec24a", "organism": "Mouse", "refseq_name": "protein transport protein Sec24A isoform 2", "refseq_ac": [ { "id": "NP_001277714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277714", "type": "external" } ], "gene_names_uniprotkb": "Sec24a", "gene_names_refseq": "Sec24a", "protein_names_uniprotkb": "Protein transport protein Sec24A; SEC24-related protein A", "protein_names_refseq": "SEC24-related protein A; Sec24 related gene family, member A; protein transport protein Sec24A isoform 2; protein transport protein Sec24A", "tax_id": 10090, "disease": "", "pathway": " (mmu:77371); (R-MMU-204005); (R-MMU-2132295); (R-MMU-5694530); (R-MMU-983170)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;18630941;21750661;23580231;25428506;30084848;30779550;31219806;34428180;36064721", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes., [UniProtKB, UniProtKB]; Hepatic LDLR levels are up-regulated in SEC24A-deficient cells as a consequence of specific dependence of PCSK9, a negative regulator of LDLR, on SEC24A for efficient exit from the ensoplasmic reticulum. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AA70;A2AA73;A4FUV4;Q3TQ05;Q3TRG7;Q8BIS0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0042632 cholesterol homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3U2P1-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHK2-1", "uniprot_id": [ { "id": "SCN3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHK2", "type": "external" } ], "mass": 24789.0, "length": 215, "protein_name": "Sodium channel regulatory subunit beta-3", "gene_name": "Scn3b", "organism": "Mouse", "refseq_name": "sodium channel regulatory subunit beta-3 isoform a precursor", "refseq_ac": [ { "id": "NP_001077386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077386", "type": "external" } ], "gene_names_uniprotkb": "Scn3b", "gene_names_refseq": "1110001K16Rik; 4833414B02Rik; Scn3b; Scnb3", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-3", "protein_names_refseq": "brain and heart sodium channel beta 3 subunit; sodium channel regulatory subunit beta-3 isoform a precursor; sodium channel regulatory subunit beta-3; sodium channel subunit beta-3", "tax_id": 10090, "disease": "Brugada syndrome 7 (Disease Ontology:DOID:0110224); brain edema (Disease Ontology:DOID:4724)", "pathway": " (mmu:235281)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;15334053;21750661", "class_list": "", "function": "Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (By similarity). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5. Could also regulate the atypical sodium channel SCN7A/Nav2.1. Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z99", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030018 Z disc;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0007399 nervous system development;GO:0072659 protein localization to plasma membrane;GO:0051899 membrane depolarization;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BHK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY62-1", "uniprot_id": [ { "id": "RN181_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY62", "type": "external" } ], "mass": 19101.0, "length": 165, "protein_name": "E3 ubiquitin-protein ligase RNF181", "gene_name": "Rnf181", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF181 isoform 2", "refseq_ac": [ { "id": "NP_001318096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318096", "type": "external" } ], "gene_names_uniprotkb": "Rnf181", "gene_names_refseq": "1700047F16Rik; 2500002L14Rik; 6230415N01Rik; Rnf181", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF181; 2.3.2.27; RING finger protein 181", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF181 isoform 2; E3 ubiquitin-protein ligase RNF181; RING-type E3 ubiquitin transferase RNF181", "tax_id": 10090, "disease": "", "pathway": " (mmu:66510); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;33300544;34052676", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEU6;Q9D2T4", "ec_number_list": [ { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CY62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPR5-1", "uniprot_id": [ { "id": "RM15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPR5", "type": "external" } ], "mass": 33542.0, "length": 295, "protein_name": "Large ribosomal subunit protein uL15m", "gene_name": "Mrpl15", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL15m isoform 1 precursor", "refseq_ac": [ { "id": "NP_001171129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171129", "type": "external" } ], "gene_names_uniprotkb": "Mrpl15", "gene_names_refseq": "HSPC145; L15mt; MRP-L15; MRP-L7; Mrpl15; Rpml7", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15m; 39S ribosomal protein L15, mitochondrial; L15mt; MRP-L15", "protein_names_refseq": "39S ribosomal protein L15, mitochondrial; large ribosomal subunit protein uL15m isoform 1 precursor; large ribosomal subunit protein uL15m; ribosomal protein, mitochondrial, L7", "tax_id": 10090, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (mmu:27395); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBN5;Q9CPP5;Q9CRH4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006412 translation;GO:0007005 mitochondrion organization;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CPR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9Z1-1", "uniprot_id": [ { "id": "SKAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9Z1", "type": "external" } ], "mass": 34728.0, "length": 312, "protein_name": "Small kinetochore-associated protein", "gene_name": "Knstrn", "organism": "Mouse", "refseq_name": "small kinetochore-associated protein", "refseq_ac": [ { "id": "NP_080688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080688", "type": "external" } ], "gene_names_uniprotkb": "Knstrn; D2Ertd750e; Skap; Traf4af1", "gene_names_refseq": "1700025D04Rik; C15orf23; D2Ertd750e; Gm14090; Knstrn; SKAP; Traf4af1", "protein_names_uniprotkb": "Small kinetochore-associated protein; Kinastrin; Kinetochore-localized astrin-binding protein; Kinetochore-localized astrin/SPAG5-binding protein; SKAP; TRAF4-associated factor 1", "protein_names_refseq": "TRAF4 associated factor 1 homolog; kinastrin; kinetochore-localized astrin-binding protein; kinetochore-localized astrin/SPAG5-binding protein; putative TRAF4-associated factor 1; small kinetochore-associated protein", "tax_id": 10090, "disease": "skin squamous cell carcinoma (Disease Ontology:DOID:3151); actinic keratosis (Disease Ontology:DOID:8866)", "pathway": " (mmu:51944)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25153642;26667018;28528544", "class_list": "", "function": "Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division., [UniProtKB, UniProtKB]; Important role in the successful outcome of male gametogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2D9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005815 microtubule organizing center;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0051301 cell division;GO:0051988 regulation of attachment of spindle microtubules to kinetochore;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D9Z1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63271-1", "uniprot_id": [ { "id": "SPT4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P63271", "type": "external" } ], "mass": 13193.0, "length": 117, "protein_name": "Transcription elongation factor SPT4-A", "gene_name": "Supt4a; Supt4h1a", "organism": "Mouse", "refseq_name": "transcription elongation factor SPT4-A isoform 1", "refseq_ac": [ { "id": "NP_033322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033322", "type": "external" } ], "gene_names_uniprotkb": "Supt4a; Supt4h1a; Spt4h; Supt4a; Supt4h1; Supt4h", "gene_names_refseq": "Supt4a; Supt4h1a; Supt4h1; Supt4h", "protein_names_uniprotkb": "Transcription elongation factor SPT4-A; DRB sensitivity-inducing factor small subunit 1; DSIF small subunit 1; Transcription elongation factor SPT4 1", "protein_names_refseq": "DRB sensitivity-inducing factor small subunit 1; DSIF small subunit 1; Transcription elongation factor SPT4-A; suppressor of Ty 4 homolog 1; suppressor of Ty 4A; transcription elongation factor SPT4 1; transcription elongation factor SPT4-A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:20922); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6807505); (R-MMU-75955)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "12042320;21750661;22570620;25760041;8786137;9776760", "class_list": "", "function": "Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity)., [UniProtKB]; Our findings indicate that Spt4 and Spt5 have essential functions in the DNA repair phase of immunoglobulin class switch recombination., [RefSeq, PubMed]; Reduction of SUPT4H in mouse brains is associated with decreased HTT protein aggregation, and in R6/2 mice, also with prolonged lifespan and delay of the motor impairment that normally develops in these animals. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGH6;Q16550;Q3TIA2;Q5NCP8;Q5NCP9;Q5NCQ0;Q62387", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000993 RNA polymerase II complex binding;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0032044 DSIF complex;GO:0005634 nucleus", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63271-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923G2-1", "uniprot_id": [ { "id": "RPAB3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923G2", "type": "external" } ], "mass": 17143.0, "length": 150, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3", "gene_name": "Polr2h", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1", "refseq_ac": [ { "id": "NP_663607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663607", "type": "external" } ], "gene_names_uniprotkb": "Polr2h", "gene_names_refseq": "Polr2h", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-directed RNA polymerase II subunit H; RNA polymerases I, II, and III subunit ABC3; RPB17; RPB8 homolog", "protein_names_refseq": "DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1; DNA-directed RNA polymerases I, II, and III subunit RPABC3; RNA polymerases I, II, and III subunit ABC3; RPB17; RPB8 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:245841); (R-MMU-112382); (R-MMU-113418); (R-MMU-5250924); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 29, "publication_count": 2, "publication_id_list": "21750661;33300544", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TT30", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q923G2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YJ2-1", "uniprot_id": [ { "id": "SNX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YJ2", "type": "external" } ], "mass": 51778.0, "length": 450, "protein_name": "Sorting nexin-4", "gene_name": "Snx4", "organism": "Mouse", "refseq_name": "sorting nexin-4", "refseq_ac": [ { "id": "NP_542124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542124", "type": "external" } ], "gene_names_uniprotkb": "Snx4", "gene_names_refseq": "1810036H14Rik; Snx4", "protein_names_uniprotkb": "Sorting nexin-4", "protein_names_refseq": "sorting nexin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69150)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12668730;21750661;25428506;28109317;31219806;33106523", "class_list": "", "function": "Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A., [UniProtKB, UniProtKB]; Results indicate that SNX4-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression. Publication Status: Online-Only, [RefSeq, PubMed]; Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking, [RefSeq, PubMed]; The endosomal protein sorting nexin 4 is a synaptic protein. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005154 epidermal growth factor receptor binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling;GO:1903595 positive regulation of histamine secretion by mast cell;GO:2000786 positive regulation of autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91YJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUR6-1", "uniprot_id": [ { "id": "PPCE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUR6", "type": "external" } ], "mass": 80752.0, "length": 710, "protein_name": "Prolyl endopeptidase", "gene_name": "Prep", "organism": "Mouse", "refseq_name": "prolyl endopeptidase", "refseq_ac": [ { "id": "NP_035286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035286", "type": "external" } ], "gene_names_uniprotkb": "Prep; Pep", "gene_names_refseq": "D10Wsu136e; PEP; PE; Pop; Prep", "protein_names_uniprotkb": "Prolyl endopeptidase; 3.4.21.26; PE; Post-proline cleaving enzyme", "protein_names_refseq": "post-proline cleaving enzyme; prolyl endopeptidase; prolyl oligopeptidase", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:19072)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10446174;11852073;16479539;25153642;25428506;25605945;28528544;30084848;30779550;31219806;34203471;34428180;36210013;37189369;37507081;37828378;39927985;9538240", "class_list": "", "function": "Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long., [UniProtKB]; Murine T cells expressing high activity of prolyl endopeptidase are susceptible to activation-induced cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80YS1", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9QUR6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZC7-1", "uniprot_id": [ { "id": "PKHB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZC7", "type": "external" } ], "mass": 24574.0, "length": 221, "protein_name": "Pleckstrin homology domain-containing family B member 2", "gene_name": "Plekhb2", "organism": "Mouse", "refseq_name": "pleckstrin homology domain-containing family B member 2 isoform 1", "refseq_ac": [ { "id": "NP_663491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663491", "type": "external" } ], "gene_names_uniprotkb": "Plekhb2; Evt2", "gene_names_refseq": "2310009M15Rik; Evt2; Phdc; Plekhb2; evt-2", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family B member 2; Evectin-2; PH domain-containing family B member 2", "protein_names_refseq": "PH domain-containing family B member 2; evectin-2; pleckstrin homology domain-containing family B member 2 isoform 1; pleckstrin homology domain-containing family B member 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226971)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10200314;18250455;21750661;26495903;26740625;28011936;28935714;35984892", "class_list": "", "function": "Involved in retrograde transport of recycling endosomes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDH6;Q8C4I4;Q8CA27", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0016020 membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QZC7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV52-1", "uniprot_id": [ { "id": "PLEK2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV52", "type": "external" } ], "mass": 40018.0, "length": 353, "protein_name": "Pleckstrin-2", "gene_name": "Plek2", "organism": "Mouse", "refseq_name": "pleckstrin-2", "refseq_ac": [ { "id": "NP_038766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038766", "type": "external" } ], "gene_names_uniprotkb": "Plek2", "gene_names_refseq": "Plek2", "protein_names_uniprotkb": "Pleckstrin-2", "protein_names_refseq": "pleckstrin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:27260)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10419454;10548495;33941818;34428180;37591356", "class_list": "", "function": "May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation., [UniProtKB]; Pleckstrin-2 is essential for erythropoiesis in beta-thalassemic mice, reducing apoptosis and enhancing enucleation. Publication Status: Online-Only, [RefSeq, PubMed]; Pleckstrin-2 promotes tumour immune escape from NK cells by activating the MT1-MMP-MICA signalling axis in gastric cancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0031346 positive regulation of cell projection organization;GO:0120034 positive regulation of plasma membrane bounded cell projection assembly;GO:0043131 erythrocyte enucleation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WV52-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UA37-1", "uniprot_id": [ { "id": "QRIC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UA37", "type": "external" } ], "mass": 86556.0, "length": 777, "protein_name": "Transcriptional regulator QRICH1", "gene_name": "Qrich1", "organism": "Mouse", "refseq_name": "transcriptional regulator QRICH1", "refseq_ac": [ { "id": "NP_001107591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107591", "type": "external" } ], "gene_names_uniprotkb": "Qrich1", "gene_names_refseq": "2610028H07Rik; Qrich1; b2b2404Clo", "protein_names_uniprotkb": "Transcriptional regulator QRICH1; Glutamine-rich protein 1", "protein_names_refseq": "glutamine-rich protein 1; transcriptional regulator QRICH1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69232)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.3389/fragi.2021.757801;21750661;22872234;25428506;30084848;30281152;31219806;32782141;33384352;34428180;35822049;36852467;39662754;40608935", "class_list": "", "function": "QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis., [RefSeq, PubMed]; Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352, PubMed:39662754). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (By similarity). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress (PubMed:33384352). Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (By similarity). Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (By similarity). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (By similarity). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005694 chromosome;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0001822 kidney development;GO:0045893 positive regulation of DNA-templated transcription;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3UA37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41593-1", "uniprot_id": [ { "id": "PTH1R_MOUSE", "url": "https://www.uniprot.org/uniprot/P41593", "type": "external" } ], "mass": 66372.0, "length": 591, "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "Pth1r", "organism": "Mouse", "refseq_name": "parathyroid hormone/parathyroid hormone-related peptide receptor precursor", "refseq_ac": [ { "id": "NP_001077404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077404", "type": "external" } ], "gene_names_uniprotkb": "Pth1r; Pthr1; Pthr", "gene_names_refseq": "PPR; Pth1r; Pthr1; Pthr", "protein_names_uniprotkb": "Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Parathyroid hormone 1 receptor", "protein_names_refseq": "PTH-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP receptor; PTH/PTHrP type I receptor; PTH1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor precursor; parathyroid hormone/parathyroid hormone-related peptide receptor", "tax_id": 10090, "disease": "chondrodysplasia Blomstrand type (Disease Ontology:DOID:0060387); Jansen's metaphyseal chondrodysplasia (Disease Ontology:DOID:0080020); primary failure of tooth eruption (Disease Ontology:DOID:0111341); Eiken syndrome (Disease Ontology:DOID:0111732); hypercalcemia (Disease Ontology:DOID:12678); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (mmu:19228); (R-MMU-373080); (R-MMU-418555)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;29507819;31219806;7524627;8197183", "class_list": "", "function": "G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:8197183). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62119;Q80WU8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41593-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DD06-1", "uniprot_id": [ { "id": "RARR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DD06", "type": "external" } ], "mass": 18350.0, "length": 162, "protein_name": "Retinoic acid receptor responder protein 2", "gene_name": "Rarres2", "organism": "Mouse", "refseq_name": "retinoic acid receptor responder protein 2 isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001334097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334097", "type": "external" } ], "gene_names_uniprotkb": "Rarres2", "gene_names_refseq": "0610007L05Rik; Rarres2", "protein_names_uniprotkb": "Retinoic acid receptor responder protein 2; Chemerin", "protein_names_refseq": "chemerin; retinoic acid receptor responder protein 2 isoform 2 preproprotein; retinoic acid receptor responder protein 2", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); essential hypertension (Disease Ontology:DOID:10825); polycystic ovary syndrome (Disease Ontology:DOID:11612); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:71660); (R-MMU-114608)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "17635925;17640997;17767914;18242188;21750661;34428180;37641406;37871796;37897505;38532043", "class_list": "", "function": "Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Also acts as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin., [UniProtKB, PubMed, PubMed]; Aerobic exercise-induced decrease of chemerin improved glucose and lipid metabolism and fatty liver of diabetes mice through key metabolism enzymes and proteins., [RefSeq, PubMed]; Chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism, [RefSeq, PubMed]; Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions., [RefSeq, PubMed]; Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin., [RefSeq, PubMed]; Rarres2 is highly expressed in adipose tissue and during adipocyte differentiation., [RefSeq, PubMed]; The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection., [RefSeq, PubMed]; These data establish that chemerin is a novel adipokine that regulates adipocyte function., [RefSeq, PubMed]; Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHU8", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0097648 G protein-coupled receptor complex", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0001934 positive regulation of protein phosphorylation;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0019732 antifungal humoral response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DD06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14C51-1", "uniprot_id": [ { "id": "PTCD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14C51", "type": "external" } ], "mass": 77796.0, "length": 685, "protein_name": "Small ribosomal subunit protein mS39", "gene_name": "Ptcd3", "organism": "Mouse", "refseq_name": "small ribosomal subunit protein mS39 isoform 1 precursor", "refseq_ac": [ { "id": "NP_081551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081551", "type": "external" } ], "gene_names_uniprotkb": "Ptcd3; Mrps39", "gene_names_refseq": "2610034F17Rik; 2810422B04Rik; MRP-S39; Ptcd3", "protein_names_uniprotkb": "Small ribosomal subunit protein mS39; 28S ribosomal protein S39, mitochondrial; MRP-S39; Pentatricopeptide repeat domain-containing protein 3, mitochondrial", "protein_names_refseq": "28S ribosomal protein S39, mitochondrial; pentatricopeptide repeat domain-containing protein 3, mitochondrial; pentatricopeptide repeat-containing protein 3, mitochondrial; small ribosomal subunit protein mS39 isoform 1 precursor; small ribosomal subunit protein mS39", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 51 (Disease Ontology:DOID:0112137)", "pathway": " (mmu:69956); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;33300544;39627609", "class_list": "", "function": "Mitochondrial RNA-binding protein that has a role in mitochondrial translation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKH5;Q5XG65;Q6P9N5;Q9CZ12", "ec_number_list": [], "go_molecular_function": "GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q14C51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z423-1", "uniprot_id": [ { "id": "R212B_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z423", "type": "external" } ], "mass": 32990.0, "length": 297, "protein_name": "E3 ubiquitin-protein ligase RNF212B", "gene_name": "Rnf212b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF212B", "refseq_ac": [ { "id": "NP_001357828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357828", "type": "external" } ], "gene_names_uniprotkb": "Rnf212b; Gm10332", "gene_names_refseq": "Gm10332; Gm30805; Rnf212b", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF212B; 2.3.2.27; RING finger protein 212B", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF212B; RING finger protein C14orf164 homolog", "tax_id": 10090, "disease": "spermatogenic failure (Disease Ontology:DOID:0111910)", "pathway": " (mmu:102632837)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;38865271", "class_list": "", "function": "RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. Erratum:[Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2418611121. doi: 10.1073/pnas.2418611121. PMID: 39348550], [RefSeq, PubMed]; Ubiquitin E3 ligase that acts as a crucial factor for crossing-over (CO) formation during meiosis. Essential for normal prophase I progression and for ensuring appropriate CO designation in meiosis. Recruits key components of the cross-over machinery either directly ou indirectly, leading to the activation of the MutL-gamma complex. The function of RNF212B in CO designation is dependent on its catalytic activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Z2T6", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0000795 synaptonemal complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0007129 homologous chromosome pairing at meiosis;GO:0051026 chiasma assembly;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z423-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925F3-1", "uniprot_id": [ { "id": "R144A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925F3", "type": "external" } ], "mass": 32845.0, "length": 292, "protein_name": "E3 ubiquitin-protein ligase RNF144A", "gene_name": "Rnf144a", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF144A isoform 1", "refseq_ac": [ { "id": "NP_001075446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075446", "type": "external" } ], "gene_names_uniprotkb": "Rnf144a; Kiaa0161; Rnf144; Ubce7ip4; Uip4", "gene_names_refseq": "Rnf144a; Rnf144; UIP4; Ubce7ip4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF144A; 2.3.2.31; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF144A isoform 1; probable E3 ubiquitin-protein ligase RNF144A; ubcM4-interacting protein 4; ubiquitin-conjugating enzyme 7-interacting protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:108089); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10431818;21750661;34400221;37955227", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol., [UniProtKB, UniProtKB]; RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis., [RefSeq, PubMed]; RNF144A promotes antiviral responses by modulating STING ubiquitination., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZZ0;Q6A0B4", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0002221 pattern recognition receptor signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0085020 protein K6-linked ubiquitination;GO:0002753 cytoplasmic pattern recognition receptor signaling pathway;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q925F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35290-1", "uniprot_id": [ { "id": "RAB24_MOUSE", "url": "https://www.uniprot.org/uniprot/P35290", "type": "external" } ], "mass": 23144.0, "length": 203, "protein_name": "Ras-related protein Rab-24", "gene_name": "Rab24", "organism": "Mouse", "refseq_name": "ras-related protein Rab-24 isoform 1", "refseq_ac": [ { "id": "NP_033026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033026", "type": "external" } ], "gene_names_uniprotkb": "Rab24", "gene_names_refseq": "6530406O07Rik; Rab24", "protein_names_uniprotkb": "Ras-related protein Rab-24; 3.6.5.2; Rab-16", "protein_names_refseq": "rab-16; ras-related protein Rab-24 isoform 1; ras-related protein Rab-24", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:19336); (R-MMU-6798695); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10660536;12323076;14680817;1555775;21750661;26325487;31496367;8126105", "class_list": "", "function": "Rab24 functions in meiotic apparatus assembly and maturational progression in mouse oocyte., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:26325487, PubMed:31496367). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:10660536, PubMed:26325487, PubMed:31496367). RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state (PubMed:10660536). RAB24 is required for the clearance of late autophagic vacuoles under basal conditions (PubMed:26325487). It is not needed for starvation-induced autophagy (PubMed:26325487). Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction (PubMed:31496367)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005819 spindle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0006914 autophagy;GO:0001556 oocyte maturation;GO:0140013 meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35290-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LH2-1", "uniprot_id": [ { "id": "PTSS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LH2", "type": "external" } ], "mass": 55604.0, "length": 473, "protein_name": "Phosphatidylserine synthase 1", "gene_name": "Ptdss1", "organism": "Mouse", "refseq_name": "phosphatidylserine synthase 1", "refseq_ac": [ { "id": "NP_032985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032985", "type": "external" } ], "gene_names_uniprotkb": "Ptdss1; Pssa", "gene_names_refseq": "PSS-1; Ptdss1; mKIAA0024", "protein_names_uniprotkb": "Phosphatidylserine synthase 1; 2.7.8.29; PSS-1; PtdSer synthase 1; Serine-exchange enzyme I", "protein_names_refseq": "PtdSer Synthase-1; phosphatidylserine synthase 1; ptdSer synthase 1; serine-exchange enzyme I", "tax_id": 10090, "disease": "Lenz-Majewski hyperostotic dwarfism (Disease Ontology:DOID:0111507)", "pathway": " (mmu:19210); (R-MMU-1483101)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10432300;10938271;18343815;21068393;21183079;21750661;35425959;9516423", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Phosphatidylserine Synthase PTDSS1 Shapes the Tumor Lipidome to Maintain Tumor-Promoting Inflammation., [RefSeq, PubMed]; Site-directed mutagenesis of binding sites within the Pss1 promoter demonstrated that Sp and N-Myc synergistically activate Pss1 expression in astrocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55024;Q3UV14;Q8C2S8", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0106258 L-serine-phosphatidylcholine phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99LH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXG2-1", "uniprot_id": [ { "id": "RAE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXG2", "type": "external" } ], "mass": 73977.0, "length": 665, "protein_name": "Rab proteins geranylgeranyltransferase component A 1", "gene_name": "Chm", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chm; Rep1", "gene_names_refseq": "", "protein_names_uniprotkb": "Rab proteins geranylgeranyltransferase component A 1; Choroideremia protein homolog; REP-1; Rab escort protein 1", "protein_names_refseq": "", "tax_id": 10090, "disease": "choroideremia (Disease Ontology:DOID:9821)", "pathway": " (R-MMU-6803205); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30779550", "class_list": "", "function": "Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane., [UniProtKB, UniProtKB]; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80UV8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0001568 blood vessel development;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QXG2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFE3-1", "uniprot_id": [ { "id": "RA54B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFE3", "type": "external" } ], "mass": 99338.0, "length": 886, "protein_name": "DNA repair and recombination protein RAD54B", "gene_name": "Rad54b", "organism": "Mouse", "refseq_name": "DNA repair and recombination protein RAD54B isoform 1", "refseq_ac": [ { "id": "NP_001034645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034645", "type": "external" } ], "gene_names_uniprotkb": "Rad54b", "gene_names_refseq": "E130016E03Rik; Rad54b", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54B; 3.6.4.-; RAD54 homolog B", "protein_names_refseq": "DNA repair and recombination protein RAD54B isoform 1; DNA repair and recombination protein RAD54B", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:623474)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;25428506;30084848;30204892;30779550;31219806;33823233;37748205;40885482", "class_list": "", "function": "Multifunctional ATPase that could play with RAD54, a redundant role in homologous recombination (HR), a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Could act as a molecular motor during the homology search and guide RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism (By similarity). Once DNA strand exchange occured, could dissociate RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). May also function as a molecular adapter, promoting MDM2-MDM4 heterodimerization to facilitate the ubiquitin-dependent degradation of p53, thereby modulating the cellular decision between cell cycle arrest and progression in response to DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway., [RefSeq, PubMed]; Rad54/Rad54B deficiency may impact on the DNA integrity of developing mouse gametes., [RefSeq, PubMed]; Susceptibility to DNA damage caused by abrogation of Rad54 homolog B: A putative mechanism for chemically induced cleft palate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AIV0", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0016887 ATP hydrolysis activity;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0009410 response to xenobiotic stimulus;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6PFE3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJW0-1", "uniprot_id": [ { "id": "PXMP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJW0", "type": "external" } ], "mass": 24196.0, "length": 212, "protein_name": "Peroxisomal membrane protein 4", "gene_name": "Pxmp4", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein 4 isoform 1", "refseq_ac": [ { "id": "NP_067509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067509", "type": "external" } ], "gene_names_uniprotkb": "Pxmp4; Pmp24", "gene_names_refseq": "3010018P03Rik; Pmp24; Pxmp4", "protein_names_uniprotkb": "Peroxisomal membrane protein 4; 24 kDa peroxisomal intrinsic membrane protein", "protein_names_refseq": "24 kDa intrinsic membrane protein; 24 kDa peroxisomal intrinsic membrane protein; peroxisomal membrane protein 4 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:59038); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18714012;21750661;34428180;35169201;36210013;37453647", "class_list": "", "function": "Genetic sequences on chromosome 2 that control NKT cell numbers, [RefSeq, PubMed]; Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0L9;Q9CQV9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PV0-1", "uniprot_id": [ { "id": "PRP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PV0", "type": "external" } ], "mass": 273616.0, "length": 2335, "protein_name": "Pre-mRNA-processing-splicing factor 8", "gene_name": "Prpf8", "organism": "Mouse", "refseq_name": "pre-mRNA-processing-splicing factor 8", "refseq_ac": [ { "id": "NP_619600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619600", "type": "external" } ], "gene_names_uniprotkb": "Prpf8; Prp8", "gene_names_refseq": "D11Bwg0410e; DBF3/PRP8; Prp8; Prpf8; Sfprp8l", "protein_names_uniprotkb": "Pre-mRNA-processing-splicing factor 8; Splicing factor Prp8", "protein_names_refseq": "pre-mRNA-processing-splicing factor 8; splicing factor Prp8", "tax_id": 10090, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); retinitis pigmentosa 13 (Disease Ontology:DOID:0110403); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:192159); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11275560;15169873;17525332;21750661;22872234;25111227;25428506;25605945;29187734;30084848;30103670;30779550;31219806;33300544;34428180;37019475;37507081;37828378", "class_list": "", "function": "Knockdown of PRPF8 significantly impairs mitophagosome formation and subsequent mitochondrial clearance through the aberrant mRNA splicing of ULK1, which mediates macroautophagy/autophagy initiation., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site., [UniProtKB, UniProtKB]; Retinitis pigmentosa-associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule cells. Publication Status: Online-Only, [RefSeq, PubMed]; The mouse retinal pigment epithelium (RPE)is the primary cell affected by mutations in the RNA splicing factors (PRPF3, PRPF8, and PRPF31), and these changes occur at an early age., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5D6Q4;Q5ND30;Q5ND31;Q7TQK2;Q8BRZ5;Q8K001", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0030620 U2 snRNA binding;GO:0008237 metallopeptidase activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0030619 U1 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0071222 cellular response to lipopolysaccharide;GO:0071356 cellular response to tumor necrosis factor;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q99PV0-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61838-1", "uniprot_id": [ { "id": "PZP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61838", "type": "external" } ], "mass": 165853.0, "length": 1495, "protein_name": "Pregnancy zone protein", "gene_name": "Pzp2; Pzp", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pzp2; Pzp; A2m; Pzp", "gene_names_refseq": "", "protein_names_uniprotkb": "Pregnancy zone protein; Alpha-2-M; Alpha-2-macroglobulin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:11287)", "pathway_count": 1, "publication_count": 27, "publication_id_list": "10.1101/2023.09.13.557529;1280217;15355875;16944957;17330941;20571061;21750661;24788674;25428506;26495903;26740625;28011936;30084848;30899004;31219806;31361958;31599954;32152506;34428180;35820727;35984892;36210013;36288343;37507081;39627609;39927985;7528166", "class_list": "", "function": "Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 9, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 9, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 9, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 21, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "E9QPW0;Q60628;Q6PEM2", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "Q61838-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923S9-1", "uniprot_id": [ { "id": "RAB30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923S9", "type": "external" } ], "mass": 23058.0, "length": 203, "protein_name": "Ras-related protein Rab-30", "gene_name": "Rab30", "organism": "Mouse", "refseq_name": "ras-related protein Rab-30", "refseq_ac": [ { "id": "NP_083770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083770", "type": "external" } ], "gene_names_uniprotkb": "Rab30; Rsb30", "gene_names_refseq": "5033421K01Rik; Rab30; Rsb30", "protein_names_uniprotkb": "Ras-related protein Rab-30; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-30", "tax_id": 10090, "disease": "", "pathway": " (mmu:75985); (R-MMU-6811438); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21308349;21750661;22960262;34428180;38796472", "class_list": "", "function": "Rab30 and S100a8/S100a9 were indicated to play roles in the initiation of liver regeneration as well as possibly in the functional switch of the liver in the newborn stage., [RefSeq, PubMed]; Rab30 facilitates lipid homeostasis during fasting. Publication Status: Online-Only, [RefSeq, PubMed]; Rabs may participate in inflammatory response in microglia during brain inflammation., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38796472). RAB30 is required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity). Facilitates lipid homeostasis during fasting by regulating hepatic protein and lipid trafficking in a PPAR-alpha-dependent manner (PubMed:38796472). Promotes autophagosome biogenesis during bacterial infection such as group A Streptococcus infection (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UQR3;Q9D3Q6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0031410 cytoplasmic vesicle;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q923S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35276-1", "uniprot_id": [ { "id": "RAB3D_MOUSE", "url": "https://www.uniprot.org/uniprot/P35276", "type": "external" } ], "mass": 24416.0, "length": 219, "protein_name": "Ras-related protein Rab-3D", "gene_name": "Rab3d", "organism": "Mouse", "refseq_name": "ras-related protein Rab-3D", "refseq_ac": [ { "id": "NP_001311460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311460", "type": "external" } ], "gene_names_uniprotkb": "Rab3d", "gene_names_refseq": "C130057E11Rik; Rab3d", "protein_names_uniprotkb": "Ras-related protein Rab-3D; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3D", "tax_id": 10090, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:19340); (R-MMU-6798695); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10891340;11431472;12578829;1594612;18849981;21750661;26495903;29125462;33300544;34273154;38591519", "class_list": "", "function": "Alcohol-induced Golgiphagy is triggered by the downregulation of Golgi GTPase RAB3D., [RefSeq, PubMed]; MicroRNA-125a-5p modulates the proliferation and apoptosis of TM4 Sertoli cells by targeting RAB3D and regulating the PI3K/AKT signaling pathway., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (PubMed:1594612)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:1903307 positive regulation of regulated secretory pathway;GO:0015031 protein transport;GO:0045453 bone resorption;GO:0006887 exocytosis;GO:0018125 peptidyl-cysteine methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35276-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CAM5-1", "uniprot_id": [ { "id": "RAB36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CAM5", "type": "external" } ], "mass": 29776.0, "length": 267, "protein_name": "Ras-related protein Rab-36", "gene_name": "Rab36", "organism": "Mouse", "refseq_name": "ras-related protein Rab-36", "refseq_ac": [ { "id": "NP_001346199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001346199", "type": "external" } ], "gene_names_uniprotkb": "Rab36", "gene_names_refseq": "6330593L16Rik; Rab36", "protein_names_uniprotkb": "Ras-related protein Rab-36; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-36", "tax_id": 10090, "disease": "", "pathway": " (mmu:76877); (R-MMU-6811438); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16923123;21750661;22740695", "class_list": "", "function": "Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CAM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7N9-1", "uniprot_id": [ { "id": "PSMG4_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C7N9", "type": "external" } ], "mass": 13974.0, "length": 123, "protein_name": "Proteasome assembly chaperone 4", "gene_name": "Psmg4", "organism": "Mouse", "refseq_name": "proteasome assembly chaperone 4 isoform b", "refseq_ac": [ { "id": "NP_001094900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094900", "type": "external" } ], "gene_names_uniprotkb": "Psmg4; Pac4", "gene_names_refseq": "PAC-4; Pba4; Psmg4; mPAC4", "protein_names_uniprotkb": "Proteasome assembly chaperone 4; PAC-4; Pba4; Proteasome chaperone homolog 4; mPAC4", "protein_names_refseq": "proteasome assembly chaperone 4 isoform b; proteasome chaperone homolog 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:69666); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17707236;21750661;26740625", "class_list": "", "function": "Chaperone protein which promotes assembly of the 20S proteasome., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C7N9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CE46-1", "uniprot_id": [ { "id": "PUS7L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CE46", "type": "external" } ], "mass": 79197.0, "length": 702, "protein_name": "Pseudouridylate synthase PUS7L", "gene_name": "Pus7l", "organism": "Mouse", "refseq_name": "pseudouridylate synthase PUS7L", "refseq_ac": [ { "id": "NP_766025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766025", "type": "external" } ], "gene_names_uniprotkb": "Pus7l", "gene_names_refseq": "3000003F02Rik; Pus7l", "protein_names_uniprotkb": "Pseudouridylate synthase PUS7L; 5.4.99.-; Pseudouridylate synthase 7 homolog-like protein", "protein_names_refseq": "pseudouridylate synthase 7 homolog-like protein; pseudouridylate synthase PUS7L", "tax_id": 10090, "disease": "", "pathway": " (mmu:78895)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Pseudouridine synthase that catalyzes pseudouridylation of mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NY03;Q8C9X5", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.42", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.42", "type": "external" }, { "id": "5.4.99.28", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.28", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0001522 pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CE46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQ28-1", "uniprot_id": [ { "id": "PXDN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQ28", "type": "external" } ], "mass": 165103.0, "length": 1475, "protein_name": "Peroxidasin homolog", "gene_name": "Pxdn", "organism": "Mouse", "refseq_name": "peroxidasin homolog precursor", "refseq_ac": [ { "id": "NP_852060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852060", "type": "external" } ], "gene_names_uniprotkb": "Pxdn; Kiaa0230", "gene_names_refseq": "2310075M15Rik; E330004E07; Pxdn; VPO1; mKIAA0230", "protein_names_uniprotkb": "Peroxidasin homolog; 1.11.2.-", "protein_names_refseq": "peroxidasin homolog precursor; peroxidasin homolog", "tax_id": 10090, "disease": "anterior segment dysgenesis 7 (Disease Ontology:DOID:0080612)", "pathway": " (mmu:69675); (R-MMU-2243919)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;18848646;18929642;19590037;21750661;21907015;22842973;24895407;25428506;25708780;28424209;29626421;30084848;30899004;31219806;31817535;32571911;32675287;34679700;35820727;37828378;38000777", "class_list": "", "function": "Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer (PubMed:22842973, PubMed:25708780, PubMed:28424209, PubMed:29626421, PubMed:31817535). In turns, directly contributes to the collagen IV network-dependent fibronectin/FN and laminin assembly, which is required for full extracellular matrix (ECM)-mediated signaling (By similarity). Thus, sulfilimine cross-links are essential for growth factor-induced cell proliferation and survival in endothelial cells, an event essential to basement membrane integrity (By similarity). In addition, through the bromide oxidation, may promote tubulogenesis and induce angiogenesis through ERK1/2, Akt, and FAK pathways (By similarity). Moreover brominates alpha2 collagen IV chain/COL4A2 at 'Tyr-1480' and leads to bromine enrichment of the basement membranes (PubMed:32571911, PubMed:32675287). In vitro, can also catalyze the two-electron oxidation of thiocyanate and iodide and these two substrates could effectively compete with bromide and thus inhibit the formation of sulfilimine bonds (By similarity). Binds laminins (By similarity). May play a role in the organization of eyeball structure and lens development during eye development (PubMed:24895407, PubMed:31817535)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A4FU83;E9QNQ9", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "1.11.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016684 oxidoreductase activity, acting on peroxide as acceptor;GO:0005201 extracellular matrix structural constituent;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q3UQ28-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42925-1", "uniprot_id": [ { "id": "PXMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P42925", "type": "external" } ], "mass": 22266.0, "length": 194, "protein_name": "Peroxisomal membrane protein 2", "gene_name": "Pxmp2", "organism": "Mouse", "refseq_name": "peroxisomal membrane protein 2 isoform 1", "refseq_ac": [ { "id": "NP_033019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033019", "type": "external" } ], "gene_names_uniprotkb": "Pxmp2; Pmp22", "gene_names_refseq": "PMP22; Pxmp2", "protein_names_uniprotkb": "Peroxisomal membrane protein 2; 22 kDa peroxisomal membrane protein", "protein_names_refseq": "22 kDa peroxisomal membrane protein; peroxisomal membrane protein 2 isoform 1; peroxisomal membrane protein 2, 22 kDa", "tax_id": 10090, "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (mmu:19301); (R-MMU-9603798)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11470509;19352492;21750661;24726525;34428180;37453647;37507081;7551822", "class_list": "", "function": "Pxmp2 channel, with an estimated diameter of 1.4 nm, shows weak cation selectivity and no voltage dependence. The long-lasting open states of the channel indicate its functional role as a protein forming a general diffusion pore in the membrane, [RefSeq, PubMed]; Pxmp2 in the mammary fat pad is plays a critical role in stromal lipid homeostasis and in development of mammary gland epithelium in mice, [RefSeq, PubMed]; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERF1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P42925-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35595-1", "uniprot_id": [ { "id": "PTC2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35595", "type": "external" } ], "mass": 128586.0, "length": 1182, "protein_name": "Protein patched homolog 2", "gene_name": "Ptch2", "organism": "Mouse", "refseq_name": "protein patched homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_032984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032984", "type": "external" } ], "gene_names_uniprotkb": "Ptch2", "gene_names_refseq": "Ptch2; ptc2", "protein_names_uniprotkb": "Protein patched homolog 2; PTC2", "protein_names_refseq": "protein patched homolog 2 isoform 1; protein patched homolog 2", "tax_id": 10090, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (mmu:19207)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12438747;16914743;21750661;25085974;27552050;31219806;34428180;9237688;9462734", "class_list": "", "function": "Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens (PubMed:25085974, PubMed:27552050). In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO (By similarity). Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signaling pathway (By similarity). Molecular mechanism governing cholesterol transport are still unclear: may move cholesterol from the outer to the inner leaflet of the membrane in exchange for potassium or sodium ion export in the opposite direction (By similarity). In contrast to PTCH1 ortholog, PTCH2 is not essential for viability and plays a more limited role (PubMed:16914743). Plays a role in epidermal homeostasis in mature skin (PubMed:16914743)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of the patched family of transmembrane receptor proteins. The encoded protein may be a functional receptor for the morphogen sonic hedgehog (Shh) and is reportedly involved in limb and skin development. Homozygous mutant mice for this gene exhibit hair loss and epidermal hyperplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AE82;Q546T0", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008158 hedgehog receptor activity;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008544 epidermis development;GO:0001558 regulation of cell growth;GO:0045606 positive regulation of epidermal cell differentiation;GO:0043588 skin development;GO:0001709 cell fate determination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35595-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55230-1", "uniprot_id": [ { "id": "RA51D_MOUSE", "url": "https://www.uniprot.org/uniprot/O55230", "type": "external" } ], "mass": 35260.0, "length": 329, "protein_name": "DNA repair protein RAD51 homolog 4", "gene_name": "Rad51d", "organism": "Mouse", "refseq_name": "DNA repair protein RAD51 homolog 4 isoform 5", "refseq_ac": [ { "id": "NP_001264871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264871", "type": "external" } ], "gene_names_uniprotkb": "Rad51d; R51h3; Rad51l3; Trad", "gene_names_refseq": "R51H3; Rad51d; Rad51l3; TRAD; Trad-d5", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 4; R51H3; RAD51 homolog D; RAD51-like protein 3", "protein_names_refseq": "DNA repair protein RAD51 homolog 4 isoform 5; DNA repair protein RAD51 homolog 4; RAD51 homolog D; RAD51-like 3; TRAD/RAD51L3", "tax_id": 10090, "disease": "hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683)", "pathway": " (mmu:19364); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10705376;14704354;15109494;15297144;19327148;21750661;25605945;27161866;28945288;9512535;9570954", "class_list": "", "function": "Contrary to isoform 1, does not show any repair activity, following treatment with mitomycin C., [UniProtKB, PubMed]; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents (PubMed:19327148). Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; RNF138 is a newly identified regulatory component of the HR mediated DNA repair pathway that has implications toward understanding how ubiquitination modifies the functions of the RAD51 paralog protein complex, [RefSeq, PubMed]; Rad51d alternative splice variants potentially modulate mechanisms of homologous recombination by sequestering either RAD51C or XRCC2 Publication Status: Online-Only, [RefSeq, PubMed]; The role of the RAD51D HR protein during thiopurine induction of mitotic catastrophe., [RefSeq, PubMed]; This gene belongs to the Rad51 gene family whose products play a major role in homologous recombination and DNA repair. The encoded protein interacts with other proteins of this family, including Rad51b, Rad51c and Xrcc2, and plays an essential role in both DNA repair and telomere maintenance. In humans, germline mutations in this gene may be associated with predisposition to ovarian cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EP65;Q9EP85;Q9EP87;Q9EP92;Q9EPA9;Q9EPC0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding;GO:0000400 four-way junction DNA binding;GO:0008094 ATP-dependent activity, acting on DNA;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005657 replication fork", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O55230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2YMG0-1", "uniprot_id": [ { "id": "PRS56_MOUSE", "url": "https://www.uniprot.org/uniprot/F2YMG0", "type": "external" } ], "mass": 65134.0, "length": 604, "protein_name": "Serine protease 56", "gene_name": "Prss56", "organism": "Mouse", "refseq_name": "serine protease 56 precursor", "refseq_ac": [ { "id": "NP_081360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081360", "type": "external" } ], "gene_names_uniprotkb": "Prss56", "gene_names_refseq": "1700027L20Rik; Prss56", "protein_names_uniprotkb": "Serine protease 56; 3.4.21.-", "protein_names_refseq": "protease, serine 56; serine protease 56 precursor", "tax_id": 10090, "disease": "isolated microphthalmia 6 (Disease Ontology:DOID:0060835); nanophthalmos (Disease Ontology:DOID:0080634); angle-closure glaucoma (Disease Ontology:DOID:13550); cholangiocarcinoma (Disease Ontology:DOID:4947); refractive error (Disease Ontology:DOID:9835)", "pathway": " (mmu:69453)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21397065;21532570;25357075;31219806", "class_list": "", "function": "Serine protease required during eye development., [UniProtKB, PubMed]; Transcripts of Prss56, a gene associated with angle-closure glaucoma, posterior microphthalmia and myopia, were increased in Mfrprd6 eyes by 17-fold. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CVU9", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F2YMG0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIW9-1", "uniprot_id": [ { "id": "RALB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIW9", "type": "external" } ], "mass": 23349.0, "length": 206, "protein_name": "Ras-related protein Ral-B", "gene_name": "Ralb", "organism": "Mouse", "refseq_name": "ras-related protein Ral-B", "refseq_ac": [ { "id": "NP_071722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071722", "type": "external" } ], "gene_names_uniprotkb": "Ralb", "gene_names_refseq": "5730472O18Rik; Ralb", "protein_names_uniprotkb": "Ras-related protein Ral-B; 3.6.5.2", "protein_names_refseq": "ras-related protein Ral-B; v-ral simian leukemia viral oncogene B; v-ral simian leukemia viral oncogene homolog B (ras related)", "tax_id": 10090, "disease": "pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (mmu:64143)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11025226;20679536;21750661;23063435;31201267", "class_list": "", "function": "Endogenous RalB plays a negative role in the ingestion process of Fc gamma receptor-mediated macrophage phagocytosis., [RefSeq, PubMed]; Findings show either RALA or RALB is sufficient for tumor growth; either RALA or RALB is sufficient for cell proliferation; RALA and RALB act in a redundant fashion, [RefSeq, PubMed]; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; While lack of only one Ral GTPase was dispensable for early peripheral nerve development, ablation of both RalA and RalB resulted in persistent radial sorting defects, associated with hallmarks of deficits in Schwann cell process formation and maintenance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVS5", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030496 midbody;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0031623 receptor internalization;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0007265 Ras protein signal transduction;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIW9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B24-1", "uniprot_id": [ { "id": "PRS57_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B24", "type": "external" } ], "mass": 30341.0, "length": 284, "protein_name": "Serine protease 57", "gene_name": "Prss57", "organism": "Mouse", "refseq_name": "serine protease 57 precursor", "refseq_ac": [ { "id": "NP_001036175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036175", "type": "external" } ], "gene_names_uniprotkb": "Prss57; Prssl1", "gene_names_refseq": "2900092M14Rik; GLGL782; NSP4; Prss57; Prssl1; UNQ782", "protein_names_uniprotkb": "Serine protease 57; 3.4.21.-; NSP4; Neutrophil serine protease 4; Serine protease 1-like protein 1", "protein_names_refseq": "neutrophil serine protease 4; protease, serine 57; protease, serine-like 1; serine protease 1-like protein 1; serine protease 57 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:73106)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;33214666", "class_list": "", "function": "Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0035578 azurophil granule lumen", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14B24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08297-1", "uniprot_id": [ { "id": "RAD51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08297", "type": "external" } ], "mass": 36971.0, "length": 339, "protein_name": "DNA repair protein RAD51 homolog 1", "gene_name": "Rad51", "organism": "Mouse", "refseq_name": "DNA repair protein RAD51 homolog 1", "refseq_ac": [ { "id": "NP_035364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035364", "type": "external" } ], "gene_names_uniprotkb": "Rad51; Rad51a; Reca", "gene_names_refseq": "Rad51a; Rad51; Reca", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 1; 3.6.4.-; RAD51 homolog A", "protein_names_refseq": "DNA repair protein RAD51 homolog 1; RAD51 homolog A", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mirror movements 2 (Disease Ontology:DOID:0070637); Fanconi anemia complementation group R (Disease Ontology:DOID:0111090); hypertension (Disease Ontology:DOID:10763); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:19361); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616); (R-MMU-912446)", "pathway_count": 8, "publication_count": 19, "publication_id_list": "11684015;12531026;15834424;20976249;21750661;22305526;24108124;30272023;30746471;30760716;30949703;32345962;32463460;32610038;35547804;8341671;8358431;8692798;9126738", "class_list": "", "function": "Homologous DNA recombinase that catalyzes strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:15834424). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (By similarity). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (By similarity). RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis (By similarity). Nucleosomal DNA is peeled from the histone surface by the RAD51 filament (By similarity). Recruited to resolve stalled replication forks during replication stress (By similarity). Also required for homologous recombination during meiosis by acting as an non-catalytic accessory factor for DMC1 recombinase, enabling proper chromosome pairing and crossing over (PubMed:32610038). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 (By similarity). Also involved in interstrand cross-link repair (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAY5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006312 mitotic recombination;GO:0010833 telomere maintenance via telomere lengthening;GO:2000001 regulation of DNA damage checkpoint;GO:0032200 telomere organization;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q08297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35719-1", "uniprot_id": [ { "id": "RA51B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35719", "type": "external" } ], "mass": 38152.0, "length": 350, "protein_name": "DNA repair protein RAD51 homolog 2", "gene_name": "Rad51b", "organism": "Mouse", "refseq_name": "DNA repair protein RAD51 homolog 2 isoform 2", "refseq_ac": [ { "id": "NP_001239491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239491", "type": "external" } ], "gene_names_uniprotkb": "Rad51b; Rad51l1; Rec2", "gene_names_refseq": "R51H2; Rad51b; Rad51l1; mREC2", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 2; R51H2; RAD51 homolog B; RAD51-like protein 1", "protein_names_refseq": "DNA repair protein RAD51 homolog 2 isoform 2; DNA repair protein RAD51 homolog 2; RAD51 homolog B; RAD51-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19363); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693616); (R-MMU-983231)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "25458897;31219806;35624308;9207106", "class_list": "", "function": "A truncating variant of RAD51B associated with primary ovarian insufficiency provides insights into its meiotic and somatic functions., [RefSeq, PubMed]; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway., [UniProtKB, UniProtKB]; Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSH6;Q9D555", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0000400 four-way junction DNA binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0005657 replication fork;GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0000724 double-strand break repair via homologous recombination;GO:0001832 blastocyst growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35719-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70300-1", "uniprot_id": [ { "id": "PSPN_MOUSE", "url": "https://www.uniprot.org/uniprot/O70300", "type": "external" } ], "mass": 17031.0, "length": 156, "protein_name": "Persephin", "gene_name": "Pspn", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pspn", "gene_names_refseq": "", "protein_names_uniprotkb": "Persephin; PSP", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-5673001); (R-MMU-8853659)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12093930;9491986", "class_list": "", "function": "Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0031175 neuron projection development;GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70300-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17225-1", "uniprot_id": [ { "id": "PTBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P17225", "type": "external" } ], "mass": 59322.0, "length": 555, "protein_name": "Polypyrimidine tract-binding protein 1", "gene_name": "Ptbp1", "organism": "Mouse", "refseq_name": "polypyrimidine tract-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001070831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070831", "type": "external" } ], "gene_names_uniprotkb": "Ptbp1; Ptb", "gene_names_refseq": "HNRPI; PTB-1; PTB2; PTB3; PTB4; Ptbp1; Ptb; pPTB", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 1; Heterogeneous nuclear ribonucleoprotein I; PTB; hnRNP I", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein I; hnRNP I; polypyrimidine tract-binding protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19205); (R-MMU-6803529); (R-MMU-72163); (R-MMU-72203); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11724819;1722210;17322886;21183079;21518792;21750661;29187734;37453647;39627609", "class_list": "", "function": "Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGJ5;Q922I7", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0001069 regulatory region RNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0006397 mRNA processing;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P17225-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21841-1", "uniprot_id": [ { "id": "PSPC_MOUSE", "url": "https://www.uniprot.org/uniprot/P21841", "type": "external" } ], "mass": 21055.0, "length": 193, "protein_name": "Surfactant protein C", "gene_name": "Sftpc", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sftpc; Sftp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Surfactant protein C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SP-C; SP5", "protein_names_refseq": "", "tax_id": 10090, "disease": "desquamative interstitial pneumonia (Disease Ontology:DOID:0050158); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (R-MMU-5683826)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2254341;30084848", "class_list": "glycogene", "function": "Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0097208 alveolar lamellar body;GO:0005771 multivesicular body", "go_biological_process": "GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21841-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28650-1", "uniprot_id": [ { "id": "PURA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P28650", "type": "external" } ], "mass": 50254.0, "length": 457, "protein_name": "Adenylosuccinate synthetase isozyme 1", "gene_name": "Adss1", "organism": "Mouse", "refseq_name": "adenylosuccinate synthetase isozyme 1", "refseq_ac": [ { "id": "NP_031447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031447", "type": "external" } ], "gene_names_uniprotkb": "Adss1; ADSS1; ADSSL1; Adssl1", "gene_names_refseq": "Adss1; Adssl1; Adss", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 1; 6.3.4.4; AMPSase 1; AdSS 1; Adenylosuccinate synthetase like 1; Adenylosuccinate synthetase, basic isozyme; Adenylosuccinate synthetase, muscle isozyme; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase", "protein_names_refseq": "AMPSase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; adSS 1; adenylosuccinate synthetase 1, muscle; adenylosuccinate synthetase isozyme 1; adenylosuccinate synthetase like 1; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme", "tax_id": 10090, "disease": "sarcoma (Disease Ontology:DOID:1115)", "pathway": " (mmu:11565); (R-MMU-73817)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11560929;12004071;12186864;12482871;16981730;1939273;21750661;31219806;34203471;34428180;39927985;8308018", "class_list": "", "function": "Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed]; Plays an important role in the de novo pathway of purine nucleotide biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHQ1", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0006531 aspartate metabolic process;GO:0044209 AMP salvage;GO:0006163 purine nucleotide metabolic process;GO:0006167 AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P28650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35294-1", "uniprot_id": [ { "id": "RAB19_MOUSE", "url": "https://www.uniprot.org/uniprot/P35294", "type": "external" } ], "mass": 24398.0, "length": 217, "protein_name": "Ras-related protein Rab-19", "gene_name": "Rab19", "organism": "Mouse", "refseq_name": "ras-related protein Rab-19", "refseq_ac": [ { "id": "NP_035356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035356", "type": "external" } ], "gene_names_uniprotkb": "Rab19", "gene_names_refseq": "Rab19", "protein_names_uniprotkb": "Ras-related protein Rab-19; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:19331); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1555775;16923123;18250455;25605945;30779550;34428180;37635409;7721101", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB]; WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35697;Q6GTV2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P35294-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48759-1", "uniprot_id": [ { "id": "PTX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P48759", "type": "external" } ], "mass": 41812.0, "length": 381, "protein_name": "Pentraxin-related protein PTX3", "gene_name": "Ptx3", "organism": "Mouse", "refseq_name": "pentraxin-related protein PTX3 precursor", "refseq_ac": [ { "id": "NP_033013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033013", "type": "external" } ], "gene_names_uniprotkb": "Ptx3; Tsg14", "gene_names_refseq": "Ptx3; TSG-14", "protein_names_uniprotkb": "Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; TSG-14; Tumor necrosis factor-inducible gene 14 protein", "protein_names_refseq": "pentaxin related; pentaxin-related protein PTX3; pentraxin 3; pentraxin-related protein PTX3 precursor; pentraxin-related protein PTX3; tumor necrosis factor-inducible gene 14 protein", "tax_id": 10090, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); pulmonary aspergilloma (Disease Ontology:DOID:0050153); obstructive sleep apnea (Disease Ontology:DOID:0050848); pelvic inflammatory disease (Disease Ontology:DOID:1003); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); hepatitis C (Disease Ontology:DOID:1883)", "pathway": " (mmu:19288); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12763682;38784395;38992453;7592730;8634434;9407058", "class_list": "", "function": "PTX3 mediates PI3K/AKT/mTOR signaling to downregulate apoptosis and autophagy to attenuate myocardial injury in sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; PTX3 promotes cementum formation and cementoblast differentiation via HA/ITGB1/FAK/YAP1 signaling pathway., [RefSeq, PubMed]; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDF1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001872 (1->3)-beta-D-glucan binding;GO:0001849 complement component C1q complex binding;GO:0046790 virion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001878 response to yeast;GO:0030198 extracellular matrix organization;GO:0045087 innate immune response;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P48759-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53994-1", "uniprot_id": [ { "id": "RAB2A_MOUSE", "url": "https://www.uniprot.org/uniprot/P53994", "type": "external" } ], "mass": 23548.0, "length": 212, "protein_name": "Ras-related protein Rab-2A", "gene_name": "Rab2a", "organism": "Mouse", "refseq_name": "ras-related protein Rab-2A isoform 1", "refseq_ac": [ { "id": "NP_067493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067493", "type": "external" } ], "gene_names_uniprotkb": "Rab2a; Rab2", "gene_names_refseq": "9330148M11Rik; Rab2a; Rab2", "protein_names_uniprotkb": "Ras-related protein Rab-2A; 3.6.5.2", "protein_names_refseq": "GTP-binding protein; RAB2, member RAS oncogene family; ras-related protein Rab-2A isoform 1; ras-related protein Rab-2A", "tax_id": 10090, "disease": "", "pathway": " (mmu:59021); (R-MMU-162658); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;22645316;25428506;28063257;33300544;34714330;37828378;38935810", "class_list": "", "function": "Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable) (PubMed:28063257). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (By similarity). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (By similarity). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28063257)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UK45", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization;GO:0061909 autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P53994-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57096-1", "uniprot_id": [ { "id": "PSCA_MOUSE", "url": "https://www.uniprot.org/uniprot/P57096", "type": "external" } ], "mass": 13478.0, "length": 123, "protein_name": "Prostate stem cell antigen", "gene_name": "Psca", "organism": "Mouse", "refseq_name": "prostate stem cell antigen precursor", "refseq_ac": [ { "id": "NP_082492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082492", "type": "external" } ], "gene_names_uniprotkb": "Psca", "gene_names_refseq": "2210408B04Rik; Psca", "protein_names_uniprotkb": "Prostate stem cell antigen", "protein_names_refseq": "prostate stem cell antigen precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72373); (R-MMU-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11479226;11752398;15860580;25680266;9465086", "class_list": "", "function": "May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs., [UniProtKB, UniProtKB]; May be involved in the regulation of cell proliferation., [UniProtKB]; Sca-1-enriched prostate-regenerating cells possess multiple stem/progenitor cell properties, [RefSeq, PubMed]; This transgenic system helps define the range of cellular changes associated with altered expression of PSCA, shows that transcriptional control is a major component regulating PSCA levels., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D7U0", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0033130 acetylcholine receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0099601 regulation of neurotransmitter receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P57096-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62192-1", "uniprot_id": [ { "id": "PRS4_MOUSE", "url": "https://www.uniprot.org/uniprot/P62192", "type": "external" } ], "mass": 49185.0, "length": 440, "protein_name": "26S proteasome regulatory subunit 4", "gene_name": "Psmc1", "organism": "Mouse", "refseq_name": "26S proteasome regulatory subunit 4", "refseq_ac": [ { "id": "NP_032973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032973", "type": "external" } ], "gene_names_uniprotkb": "Psmc1", "gene_names_refseq": "P26s4; Psmc1; Rpt2/S4; S4; rpt2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; P26s4; Proteasome 26S subunit ATPase 1", "protein_names_refseq": "26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; proteasome 26S subunit ATPase 1", "tax_id": 10090, "disease": "neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (Disease Ontology:DOID:0081324); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:19179); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-532668); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 57, "publication_count": 24, "publication_id_list": "10.1101/2023.09.13.557529;11562482;15358861;16249333;16709668;16857966;19577582;21183079;23806337;25428506;25605945;26495903;27802388;28011936;30059200;30084848;30779550;31219806;31599954;34428180;35820727;37828378;39627609;8808288", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P49014;Q03527;Q96AZ3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P62192-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63089-1", "uniprot_id": [ { "id": "PTN_MOUSE", "url": "https://www.uniprot.org/uniprot/P63089", "type": "external" } ], "mass": 18869.0, "length": 168, "protein_name": "Pleiotrophin", "gene_name": "Ptn", "organism": "Mouse", "refseq_name": "pleiotrophin precursor", "refseq_ac": [ { "id": "NP_032999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032999", "type": "external" } ], "gene_names_uniprotkb": "Ptn", "gene_names_refseq": "HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF; OSF; Osf-1; Osf1; Ptn", "protein_names_uniprotkb": "Pleiotrophin; HB-GAM; HBBM; HBGF-8; HBNF; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; PTN", "protein_names_refseq": "heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neutrophic factor; osteoblast-specific factor 1; pleiotrophin precursor", "tax_id": 10090, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); adrenal carcinoma (Disease Ontology:DOID:3950); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:19242); (R-MMU-201556); (R-MMU-9851151)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11414790;12093164;1457042;15121180;1550576;16619002;1701634;17121547;1768439;19442624;21791434;25000129;27445335;28657144;30497772;37610873;37611228", "class_list": "glycogene", "function": "Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction., [RefSeq, PubMed]; Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:15121180, PubMed:19442624, PubMed:27445335, PubMed:30497772). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (PubMed:11414790, PubMed:25000129). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (PubMed:30497772). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (PubMed:15121180). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (PubMed:21791434). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (PubMed:16619002, PubMed:17121547, PubMed:28657144)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 14, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20935", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:1904399 heparan sulfate binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0048680 positive regulation of axon regeneration;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007229 integrin-mediated signaling pathway;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63089-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70303-1", "uniprot_id": [ { "id": "PYRG2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70303", "type": "external" } ], "mass": 65514.0, "length": 586, "protein_name": "CTP synthase 2", "gene_name": "Ctps2", "organism": "Mouse", "refseq_name": "CTP synthase 2 isoform a", "refseq_ac": [ { "id": "NP_001162040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162040", "type": "external" } ], "gene_names_uniprotkb": "Ctps2", "gene_names_refseq": "A830031M15Rik; Ctps2; Ctpsh", "protein_names_uniprotkb": "CTP synthase 2; 6.3.4.2; CTP synthetase 2; CTPsH; UTP--ammonia ligase 2", "protein_names_refseq": "CTP synthase 2 isoform a; CTP synthase 2; CTP synthetase 2; CTP synthetase homolog; UTP--ammonia ligase 2; cytidine triphosphate synthase II", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:55936); (R-MMU-499943)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "21183079;21750661;30084848;34428180;34583994;38438357;39627609", "class_list": "", "function": "CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPQ2;Q3TT59", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097268 cytoophidium", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70303-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70388-1", "uniprot_id": [ { "id": "RAD50_MOUSE", "url": "https://www.uniprot.org/uniprot/P70388", "type": "external" } ], "mass": 153488.0, "length": 1312, "protein_name": "DNA repair protein RAD50", "gene_name": "Rad50", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rad50", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair protein RAD50; 3.6.-.-; mRad50", "protein_names_refseq": "", "tax_id": 10090, "disease": "breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (mmu:19360); (R-MMU-2559586); (R-MMU-5685938); (R-MMU-5685939); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693548); (R-MMU-5693565); (R-MMU-5693568); (R-MMU-5693571); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 15, "publication_count": 16, "publication_id_list": "10377422;12208847;12542794;17525332;21183079;21750661;25605945;30017584;30084848;30779550;31219806;34428180;34887587;36210013;39627609;8910585", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:10377422, PubMed:12208847). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the complex, RAD50 is both required to bind DNA ends and hold them in close proximity and regulate the activity of MRE11 (By similarity). RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open form with accessible MRE11 nuclease sites into a closed form (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (By similarity). The MRN complex is also required for the processing of R-loops. In telomeres the MRN complex may modulate t-loop formation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PEB0;Q8C2T7;Q9CU59", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006974 DNA damage response;GO:0007346 regulation of mitotic cell cycle;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P70388-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05144-1", "uniprot_id": [ { "id": "RAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05144", "type": "external" } ], "mass": 21441.0, "length": 192, "protein_name": "Ras-related C3 botulinum toxin substrate 2", "gene_name": "Rac2", "organism": "Mouse", "refseq_name": "ras-related C3 botulinum toxin substrate 2", "refseq_ac": [ { "id": "NP_033034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033034", "type": "external" } ], "gene_names_uniprotkb": "Rac2", "gene_names_refseq": "Rac2", "protein_names_uniprotkb": "Ras-related C3 botulinum toxin substrate 2; 3.6.5.2; Protein EN-7; p21-Rac2", "protein_names_refseq": "EN-7 protein; RAS-related C3 botulinum substrate 2; p21-Rac2; protein EN-7; ras-related C3 botulinum toxin substrate 2", "tax_id": 10090, "disease": "autosomal dominant intellectual developmental disorder 48 (Disease Ontology:DOID:0080235); immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia (Disease Ontology:DOID:0112061); immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia (Disease Ontology:DOID:0112062); immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis (Disease Ontology:DOID:0112064); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); kidney disease (Disease Ontology:DOID:557)", "pathway": " (mmu:19354); (R-MMU-114604); (R-MMU-1222556); (R-MMU-1257604); (R-MMU-4086400); (R-MMU-5668599); (R-MMU-6811558); (R-MMU-9013404)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "21750661;2189110;27084103;30084848;30779550;33300544;34428180;36462643;37017007;39627609", "class_list": "", "function": "HIF-1alpha promotes paraquat induced acute lung injury and implicates a role NF-kappaB and Rac2 activity., [RefSeq, PubMed]; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). Activates PLCG2., [UniProtKB, UniProtKB]; Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBC4;Q9D8X9", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019887 protein kinase regulator activity;GO:0003925 G protein activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006935 chemotaxis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05144-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08761-1", "uniprot_id": [ { "id": "PROS_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08761", "type": "external" } ], "mass": 74934.0, "length": 675, "protein_name": "Vitamin K-dependent protein S", "gene_name": "Pros1", "organism": "Mouse", "refseq_name": "vitamin K-dependent protein S preproprotein", "refseq_ac": [ { "id": "NP_035303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035303", "type": "external" } ], "gene_names_uniprotkb": "Pros1; Pros", "gene_names_refseq": "Pros1", "protein_names_uniprotkb": "Vitamin K-dependent protein S", "protein_names_refseq": "vitamin K-dependent protein S preproprotein; vitamin K-dependent protein S", "tax_id": 10090, "disease": "autosomal dominant thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111900); autosomal recessive thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111905); protein S deficiency (Disease Ontology:DOID:2451); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (mmu:19128); (R-MMU-114608); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-202733); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "33848267;34428180;36951067;36989576;37277061;8029814;8148380", "class_list": "", "function": "Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis., [UniProtKB]; Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration., [RefSeq, PubMed]; Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification., [RefSeq, PubMed]; Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation., [RefSeq, PubMed]; Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10., [RefSeq, PubMed]; This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P43483", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0050766 positive regulation of phagocytosis;GO:0050819 negative regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08761-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14B25-1", "uniprot_id": [ { "id": "PRS48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14B25", "type": "external" } ], "mass": 34637.0, "length": 312, "protein_name": "Serine protease 48", "gene_name": "Prss48", "organism": "Mouse", "refseq_name": "serine protease 48 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001001650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001650", "type": "external" } ], "gene_names_uniprotkb": "Prss48; Esspl; Gm1019", "gene_names_refseq": "Esspl; Gm1019; Prss48", "protein_names_uniprotkb": "Serine protease 48; 3.4.21.-; Epidermis-specific serine protease-like protein", "protein_names_refseq": "epidermis-specific serine protease-like protein; protease, serine 48; serine protease 48 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:368202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12838346", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7M755", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q14B25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UNZ8-1", "uniprot_id": [ { "id": "QORL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UNZ8", "type": "external" } ], "mass": 37809.0, "length": 350, "protein_name": "Protein Cryzl2", "gene_name": "Cryzl2", "organism": "Mouse", "refseq_name": "protein Cryzl2 isoform 1", "refseq_ac": [ { "id": "NP_001028456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028456", "type": "external" } ], "gene_names_uniprotkb": "Cryzl2; BC026585", "gene_names_refseq": "Cryzl2", "protein_names_uniprotkb": "Protein Cryzl2; Crystallin zeta like 2", "protein_names_refseq": "protein Cryzl2 isoform 1; protein Cryzl2; quinone oxidoreductase-like protein 2; quinone reductase-like 2; zeta-crystallin homolog 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:226527)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;23576753;23806337", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UAM2", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3UNZ8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPH1-1", "uniprot_id": [ { "id": "PRRC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPH1", "type": "external" } ], "mass": 46298.0, "length": 443, "protein_name": "Protein PRRC1", "gene_name": "Prrc1", "organism": "Mouse", "refseq_name": "protein PRRC1", "refseq_ac": [ { "id": "NP_082723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082723", "type": "external" } ], "gene_names_uniprotkb": "Prrc1", "gene_names_refseq": "1190002C06Rik; 2310058D16Rik; 3110038B19Rik; 9430085A19Rik; Prrc1", "protein_names_uniprotkb": "Protein PRRC1; Proline-rich and coiled-coil-containing protein 1", "protein_names_refseq": "proline-rich and coiled-coil-containing protein 1; protein PRRC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73137)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;21540332;21750661;26495903;26740625;27802388;28011936;29187734;30779550;31599954;34428180;36064721;39927985;40885482;40997131", "class_list": "", "function": "May act as a regulator of the protein kinase A (PKA) during embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91YT1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010669 epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q3UPH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3Q4-1", "uniprot_id": [ { "id": "IFI8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3Q4", "type": "external" } ], "mass": 63866.0, "length": 588, "protein_name": "Interferon-activable protein 208", "gene_name": "Ifi208", "organism": "Mouse", "refseq_name": "interferon-activable protein 208 isoform 1", "refseq_ac": [ { "id": "NP_001156410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156410", "type": "external" } ], "gene_names_uniprotkb": "Ifi208; Pydc3", "gene_names_refseq": "9830148g24rik; E430029J22Rik; Ifi208; NG2creBAC; Pydc3; Pyr-rv1; Tg(Cspg4-cre)1Akik", "protein_names_uniprotkb": "Interferon-activable protein 208; Ifi-204-like; Interferon activated gene 208; Interferon-activable protein 204-like; Pyrin domain-containing protein 3", "protein_names_refseq": "inteferon-activable protein 208; interferon-activable protein 208 isoform 1; interferon-activable protein 208; pyrin domain containing 3; pyrin domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:100033459)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30084848;30779550", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLW5", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002218 activation of innate immune response;GO:0035458 cellular response to interferon-beta", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V3Q4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q504M8-1", "uniprot_id": [ { "id": "RAB26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q504M8", "type": "external" } ], "mass": 28619.0, "length": 260, "protein_name": "Ras-related protein Rab-26", "gene_name": "Rab26", "organism": "Mouse", "refseq_name": "ras-related protein Rab-26", "refseq_ac": [ { "id": "NP_796349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796349", "type": "external" } ], "gene_names_uniprotkb": "Rab26", "gene_names_refseq": "A830020M03Rik; Rab26", "protein_names_uniprotkb": "Ras-related protein Rab-26; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-26", "tax_id": 10090, "disease": "", "pathway": " (mmu:328778); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12578829;20038531;21750661;37060270;37289842;38169213", "class_list": "", "function": "MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D., [RefSeq, PubMed]; Rab26 alleviates sepsis-induced immunosuppression as a master regulator of macrophage ferroptosis and polarization shift., [RefSeq, PubMed]; Rab26 promotes macrophage phagocytosis through regulation of MFN2 trafficking to mitochondria., [RefSeq, PubMed]; Rab26 restricts insulin secretion via sequestering Synaptotagmin-1. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019002 GMP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0043001 Golgi to plasma membrane protein transport;GO:0017157 regulation of exocytosis;GO:0035272 exocrine system development;GO:0140251 regulation protein catabolic process at presynapse", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q504M8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q571E5-1", "uniprot_id": [ { "id": "PRS53_MOUSE", "url": "https://www.uniprot.org/uniprot/Q571E5", "type": "external" } ], "mass": 58974.0, "length": 552, "protein_name": "Serine protease 53", "gene_name": "Prss53", "organism": "Mouse", "refseq_name": "serine protease 53 precursor", "refseq_ac": [ { "id": "NP_001074737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074737", "type": "external" } ], "gene_names_uniprotkb": "Prss53", "gene_names_refseq": "Pol3s; Prss53; mFLJ00289", "protein_names_uniprotkb": "Serine protease 53; 3.4.21.-; Polyserase-3; Polyserine protease 3", "protein_names_refseq": "Bc039632-like protein; polyserase-3; polyserine protease 3; protease, serine 53; serine protease 53 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:330657)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;34636707;35067752", "class_list": "", "function": "Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells., [RefSeq, PubMed]; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator., [UniProtKB]; Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFX9", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q571E5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60692-1", "uniprot_id": [ { "id": "PSB6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60692", "type": "external" } ], "mass": 25379.0, "length": 238, "protein_name": "Proteasome subunit beta type-6", "gene_name": "Psmb6", "organism": "Mouse", "refseq_name": "proteasome subunit beta type-6", "refseq_ac": [ { "id": "NP_032972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032972", "type": "external" } ], "gene_names_uniprotkb": "Psmb6; Lmp19", "gene_names_refseq": "Lmp19; Mpnd; Psmb6", "protein_names_uniprotkb": "Proteasome subunit beta type-6; 3.4.25.1; Low molecular mass protein 19; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit Y; Proteasome subunit beta-1; beta-1", "protein_names_refseq": "beta-1; low molecular mass protein 19; macropain delta chain; multicatalytic endopeptidase complex delta chain; proteasome delta chain; proteasome subunit Y; proteasome subunit beta type-6; proteasome subunit beta-1; subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19175); (R-MMU-1169091); (R-MMU-1234176); (R-MMU-1236974); (R-MMU-1236978); (R-MMU-174084); (R-MMU-174154); (R-MMU-174178); (R-MMU-174184); (R-MMU-187577); (R-MMU-195253); (R-MMU-202424); (R-MMU-2467813); (R-MMU-2871837); (R-MMU-349425); (R-MMU-350562); (R-MMU-382556); (R-MMU-450408); (R-MMU-4608870); (R-MMU-4641257); (R-MMU-4641258); (R-MMU-5358346); (R-MMU-5607761); (R-MMU-5607764); (R-MMU-5610780); (R-MMU-5610785); (R-MMU-5632684); (R-MMU-5658442); (R-MMU-5668541); (R-MMU-5676590); (R-MMU-5687128); (R-MMU-5689603); (R-MMU-5689880); (R-MMU-68867); (R-MMU-68949); (R-MMU-69017); (R-MMU-69481); (R-MMU-69601); (R-MMU-75815); (R-MMU-8852276); (R-MMU-8854050); (R-MMU-8939236); (R-MMU-8939902); (R-MMU-8941858); (R-MMU-8948751); (R-MMU-8951664); (R-MMU-9020702); (R-MMU-9755511); (R-MMU-9762114); (R-MMU-9766229); (R-MMU-983168); (R-MMU-9907900); (R-MMU-9912633); (R-MMU-9929356); (R-MMU-9929491); (R-MMU-9931269); (R-MMU-9932298); (R-MMU-9954709)", "pathway_count": 58, "publication_count": 12, "publication_id_list": "16581775;16857966;17521679;21455682;22341445;22872234;31219806;34203471;34428180;37453647;37828378;7797265", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues., [UniProtKB, PubMed, PubMed]; Data demonstrate that TNF-alpha expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V240;Q60693;Q8BJX9;Q91VH5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q60692-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62035-1", "uniprot_id": [ { "id": "PTAFR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62035", "type": "external" } ], "mass": 39148.0, "length": 341, "protein_name": "Platelet-activating factor receptor", "gene_name": "Ptafr", "organism": "Mouse", "refseq_name": "platelet-activating factor receptor", "refseq_ac": [ { "id": "NP_001074680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074680", "type": "external" } ], "gene_names_uniprotkb": "Ptafr", "gene_names_refseq": "PAFR; Ptafr", "protein_names_uniprotkb": "Platelet-activating factor receptor; PAF-R; PAFr", "protein_names_refseq": "PAF receptor; platelet-activating factor receptor", "tax_id": 10090, "disease": "pleurisy (Disease Ontology:DOID:10247); sciatic neuropathy (Disease Ontology:DOID:11446); neutropenia (Disease Ontology:DOID:1227); transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); conjunctivitis (Disease Ontology:DOID:6195); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (mmu:19204); (R-MMU-373076); (R-MMU-416476); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "19144319;8670084", "class_list": "", "function": "Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system., [UniProtKB]; This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1B170;Q8C017", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0051019 mitogen-activated protein kinase binding;GO:0001530 lipopolysaccharide binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:1902943 positive regulation of voltage-gated chloride channel activity;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62035-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64697-1", "uniprot_id": [ { "id": "PTCA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64697", "type": "external" } ], "mass": 20371.0, "length": 197, "protein_name": "Protein tyrosine phosphatase receptor type C-associated protein", "gene_name": "Ptprcap", "organism": "Mouse", "refseq_name": "protein tyrosine phosphatase receptor type C-associated protein", "refseq_ac": [ { "id": "NP_058629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058629", "type": "external" } ], "gene_names_uniprotkb": "Ptprcap", "gene_names_refseq": "CD-45-AP; LPAP; LSM-1; Ptprcap", "protein_names_uniprotkb": "Protein tyrosine phosphatase receptor type C-associated protein; CD45-AP; CD45-associated protein; LSM-1; PTPRC-associated protein", "protein_names_refseq": "CD45-AP; CD45-associated protein; PTPRC-associated protein; protein tyrosine phosphatase receptor type C-associated protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:19265)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12055218;14715639;21183079;21750661;34428180;35984892;7957956;8300558", "class_list": "", "function": "Results support a model in which binding of CD45-AP to inactive CD45 dimers converts them to active monomers, [RefSeq, PubMed]; The association of LPAP with CD45 is dispensable for CD45-mediated apoptosis signaling, as shown in studies of LPAP knocked-out thymocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFQ7-1", "uniprot_id": [ { "id": "RASL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFQ7", "type": "external" } ], "mass": 90060.0, "length": 802, "protein_name": "Ras GTPase-activating protein 4", "gene_name": "Rasa4", "organism": "Mouse", "refseq_name": "ras GTPase-activating protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001034192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034192", "type": "external" } ], "gene_names_uniprotkb": "Rasa4; Capri; Kiaa0538", "gene_names_refseq": "CAPRI; GAPL; Rasa4", "protein_names_uniprotkb": "Ras GTPase-activating protein 4; Calcium-promoted Ras inactivator; Ras p21 protein activator 4; RasGAP-activating-like protein 2", "protein_names_refseq": "Ca2+promoted Ras inactivator; calcium-promoted RAS inactivator; ras GTPase-activating protein 4 isoform 2; ras GTPase-activating protein 4; rasGAP-activating-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:54153); (R-MMU-5658442)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16041389;16234249;21460216;21750661;25637021;29187734;30084848;31219806;34428180;36210013", "class_list": "", "function": "Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14., [UniProtKB, PubMed, PubMed]; Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities, [RefSeq, PubMed]; Data show that calcium-promoted Ras inactivator (CAPRI) C2AB domains are required for CD28 antigen inhibition of adhesion., [RefSeq, PubMed]; DeltaCAPRI regulates RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2PMI6;Q3U2R4;Q571H1;Q58DY7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0071277 cellular response to calcium ion;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q6PFQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M756-1", "uniprot_id": [ { "id": "PRS54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M756", "type": "external" } ], "mass": 42758.0, "length": 383, "protein_name": "Inactive serine protease 54", "gene_name": "Prss54", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prss54; Klkbl4", "gene_names_refseq": "", "protein_names_uniprotkb": "Inactive serine protease 54; Plasma kallikrein-like protein 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12838346", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M756-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHD7-1", "uniprot_id": [ { "id": "PTBP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHD7", "type": "external" } ], "mass": 56701.0, "length": 523, "protein_name": "Polypyrimidine tract-binding protein 3", "gene_name": "Ptbp3", "organism": "Mouse", "refseq_name": "polypyrimidine tract-binding protein 3 isoform 1", "refseq_ac": [ { "id": "NP_659153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659153", "type": "external" } ], "gene_names_uniprotkb": "Ptbp3; Rod1", "gene_names_refseq": "5830471K22Rik; Ptbp3; Rod1", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 3; Regulator of differentiation 1; Rod1", "protein_names_refseq": "ROD1 regulator of differentiation 1; polypyrimidine tract-binding protein 3 isoform 1; regulator of differentiation 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230257)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;26495903;30084848;34214192;34428180;36210013;39116343;39627609", "class_list": "", "function": "Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice., [RefSeq, PubMed]; PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer., [RefSeq, PubMed]; RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANH0;A2ANH1;Q923C3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003676 nucleic acid binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BHD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM39-1", "uniprot_id": [ { "id": "PRP18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM39", "type": "external" } ], "mass": 39890.0, "length": 342, "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "Prpf18", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor 18 isoform 2", "refseq_ac": [ { "id": "NP_080321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080321", "type": "external" } ], "gene_names_uniprotkb": "Prpf18; Prp18", "gene_names_refseq": "2810441A10Rik; Prpf18", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 18; PRP18 homolog", "protein_names_refseq": "HPRP18 homolog; PRP18 homolog; PRP18 pre-mRNA processing factor 18 homolog; pre-mRNA-splicing factor 18 isoform 2; pre-mRNA-splicing factor 18", "tax_id": 10090, "disease": "", "pathway": " (mmu:67229); (R-MMU-72163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "Participates in the second step of pre-mRNA splicing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UX46;Q8BZ54", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0071021 U2-type post-spliceosomal complex;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0051248 negative regulation of protein metabolic process;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BM39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BTF8-1", "uniprot_id": [ { "id": "RALYL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BTF8", "type": "external" } ], "mass": 32452.0, "length": 293, "protein_name": "RNA-binding Raly-like protein", "gene_name": "Ralyl", "organism": "Mouse", "refseq_name": "RNA-binding Raly-like protein isoform a", "refseq_ac": [ { "id": "NP_001156800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156800", "type": "external" } ], "gene_names_uniprotkb": "Ralyl", "gene_names_refseq": "0710005M24Rik; Ralyl", "protein_names_uniprotkb": "RNA-binding Raly-like protein", "protein_names_refseq": "RNA-binding Raly-like protein isoform a; RNA-binding Raly-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:76897)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;33750796;40885482", "class_list": "", "function": "RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-beta2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTF9;Q8BTG1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BTF8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BV84-1", "uniprot_id": [ { "id": "PRR9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BV84", "type": "external" } ], "mass": 12797.0, "length": 116, "protein_name": "Proline-rich protein 9", "gene_name": "Prr9", "organism": "Mouse", "refseq_name": "proline-rich protein 9", "refseq_ac": [ { "id": "NP_780633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780633", "type": "external" } ], "gene_names_uniprotkb": "Prr9", "gene_names_refseq": "A030004J04Rik; Prr9", "protein_names_uniprotkb": "Proline-rich protein 9", "protein_names_refseq": "proline-rich protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:109314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BV84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW11-1", "uniprot_id": [ { "id": "PRS58_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW11", "type": "external" } ], "mass": 26865.0, "length": 241, "protein_name": "Putative inactive serine protease 58", "gene_name": "Prss58", "organism": "Mouse", "refseq_name": "putative inactive serine protease 58 precursor", "refseq_ac": [ { "id": "NP_778185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778185", "type": "external" } ], "gene_names_uniprotkb": "Prss58; Tryx3", "gene_names_refseq": "1700020H15; Prss58; Tryx3", "protein_names_uniprotkb": "Putative inactive serine protease 58; 3.4.21.4; Trypsin-X3", "protein_names_refseq": "protease, serine 58; putative inactive serine protease 58 precursor; putative inactive serine protease 58; putative trypsin-X3", "tax_id": 10090, "disease": "", "pathway": " (mmu:232717)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11160223", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:2000243 positive regulation of reproductive process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BW11-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C494-1", "uniprot_id": [ { "id": "PRR33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C494", "type": "external" } ], "mass": 28520.0, "length": 260, "protein_name": "Proline-rich protein 33", "gene_name": "Prr33", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prr33; Gm14492", "gene_names_refseq": "", "protein_names_uniprotkb": "Proline-rich protein 33", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:677289)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39927985", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8C494-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K459-1", "uniprot_id": [ { "id": "PXT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K459", "type": "external" } ], "mass": 5934.0, "length": 51, "protein_name": "Peroxisomal testis-specific protein 1", "gene_name": "Pxt1", "organism": "Mouse", "refseq_name": "peroxisomal testis-specific protein 1", "refseq_ac": [ { "id": "NP_700439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_700439", "type": "external" } ], "gene_names_uniprotkb": "Pxt1; Stepp", "gene_names_refseq": "1700001G18Rik; Pxt1; Stepp", "protein_names_uniprotkb": "Peroxisomal testis-specific protein 1; Small testis-specific peroxisomal protein", "protein_names_refseq": "peroxisomal testis-specific protein 1; small testis-specific peroxisomal protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69307)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18160785;21460186;21750661;37393946;37467697", "class_list": "", "function": "Increased DNA strand breaks in spermatozoa of Pxt1 knockout mice., [RefSeq, PubMed]; Mouse Pxt1 expression is regulated by Mir6996 miRNA., [RefSeq, PubMed]; PXT1 induces apoptosis via the BH3-like domain and that this process is inhibited by BAT3, [RefSeq, PubMed]; Pxt1 gene is so far the first gene coding for a putative peroxisomal protein which is expressed in later steps of spermatogenesis, namely in pachytene spermatocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K459-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Y8-1", "uniprot_id": [ { "id": "PTH2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Y8", "type": "external" } ], "mass": 19527.0, "length": 181, "protein_name": "Peptidyl-tRNA hydrolase 2, mitochondrial", "gene_name": "Ptrh2", "organism": "Mouse", "refseq_name": "peptidyl-tRNA hydrolase 2, mitochondrial isoform b", "refseq_ac": [ { "id": "NP_001092280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092280", "type": "external" } ], "gene_names_uniprotkb": "Ptrh2; Pth2", "gene_names_refseq": "A230072I16Rik; Bit1; CGI-147; PTH 2; Ptrh2", "protein_names_uniprotkb": "Peptidyl-tRNA hydrolase 2, mitochondrial; 3.1.1.29; PTH 2", "protein_names_refseq": "peptidyl-tRNA hydrolase 2, mitochondrial isoform b; peptidyl-tRNA hydrolase 2, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:217057); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18218778;21383007;21886829;25605945;25770104;28175314;34428180;36219306", "class_list": "", "function": "Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway, [RefSeq, PubMed]; Downregulation of Bit1 specifically potentiated tumor metastasis in vivo, [RefSeq, PubMed]; PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients., [RefSeq, PubMed]; Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1., [UniProtKB, UniProtKB]; Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle, [RefSeq, PubMed]; These results support an unanticipated yet essential role for Bit-1 in controlling myogenesis through regulation of Bcl-2., [RefSeq, PubMed]; These studies establish the physiological significance of Bit1 activity and begin to delineate a Bit1 signaling pathway that acts through Erk regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BI01;Q8BI31", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" } ], "go_molecular_function": "GO:0004045 peptidyl-tRNA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:2000210 positive regulation of anoikis;GO:2000811 negative regulation of anoikis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R2Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDV3-1", "uniprot_id": [ { "id": "R3GEF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDV3", "type": "external" } ], "mass": 42713.0, "length": 383, "protein_name": "Guanine nucleotide exchange factor for Rab-3A", "gene_name": "Rab3il1", "organism": "Mouse", "refseq_name": "guanine nucleotide exchange factor for Rab-3A isoform 2", "refseq_ac": [ { "id": "NP_001334358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334358", "type": "external" } ], "gene_names_uniprotkb": "Rab3il1", "gene_names_refseq": "1200014K04Rik; Rab3ail1; Rab3il1", "protein_names_uniprotkb": "Guanine nucleotide exchange factor for Rab-3A; Rab-3A-interacting-like protein 1; Rab3A-interacting-like protein 1; Rabin3-like 1", "protein_names_refseq": "guanine nucleotide exchange factor for Rab-3A isoform 2; guanine nucleotide exchange factor for Rab-3A; guanine nucleotide exchange factor for Rab3A; rab-3A-interacting-like protein 1; rab3A-interacting-like protein 1; rabin3-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74760); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;28096466;35820059", "class_list": "", "function": "Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts. Erratum:[Blood. 2023 Oct 5;142(14):1254. doi: 10.1182/blood.2023022213. PMID: 37796517], [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TTM0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZR1-1", "uniprot_id": [ { "id": "RAB4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZR1", "type": "external" } ], "mass": 23629.0, "length": 213, "protein_name": "Ras-related protein Rab-4B", "gene_name": "Rab4b", "organism": "Mouse", "refseq_name": "ras-related protein Rab-4B", "refseq_ac": [ { "id": "NP_083667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083667", "type": "external" } ], "gene_names_uniprotkb": "Rab4b; Rab4", "gene_names_refseq": "1500031G17Rik; Rab4b", "protein_names_uniprotkb": "Ras-related protein Rab-4B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-4B", "tax_id": 10090, "disease": "", "pathway": " (mmu:19342); (R-MMU-6798695); (R-MMU-8873719); (R-MMU-8875656)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;14697203;19590752;21750661;26740625;30566860;31219806;33300544", "class_list": "", "function": "Data conclude that Rab4b is a new important player in the control of GLUT4 trafficking in adipocyte. Publication Status: Online-Only, [RefSeq, PubMed]; The obesity-induced loss of Rab4b in adipose T cells may contribute to maladaptive white adipose tissue remodeling and insulin resistance by altering adipose T cell fate., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:14697203). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (PubMed:14697203)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0034058 endosomal vesicle fusion;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91ZR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921E2-1", "uniprot_id": [ { "id": "RAB31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921E2", "type": "external" } ], "mass": 21463.0, "length": 195, "protein_name": "Ras-related protein Rab-31", "gene_name": "Rab31", "organism": "Mouse", "refseq_name": "ras-related protein Rab-31", "refseq_ac": [ { "id": "NP_598446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598446", "type": "external" } ], "gene_names_uniprotkb": "Rab31", "gene_names_refseq": "1700093E07Rik; Rab22B; Rab31", "protein_names_uniprotkb": "Ras-related protein Rab-31; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-31", "tax_id": 10090, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (mmu:106572); (R-MMU-6798695); (R-MMU-8873719); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "17189207;19144319;19345684;19725050;22460790;25568335;26495903;35091093", "class_list": "", "function": "Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell., [RefSeq, PubMed]; Rab22B is exceptionally enriched in nestin and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP)-positive mature astrocytes., [RefSeq, PubMed]; Rab31 promotes activation of hepatic stellate cells by accelerating TGF-beta receptor II complex endocytosis., [RefSeq, PubMed]; Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKP0", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q921E2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KL7-1", "uniprot_id": [ { "id": "RAB28_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KL7", "type": "external" } ], "mass": 24728.0, "length": 221, "protein_name": "Ras-related protein Rab-28", "gene_name": "Rab28", "organism": "Mouse", "refseq_name": "ras-related protein Rab-28 isoform 1", "refseq_ac": [ { "id": "NP_081571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081571", "type": "external" } ], "gene_names_uniprotkb": "Rab28", "gene_names_refseq": "2700023P08Rik; Rab28", "protein_names_uniprotkb": "Ras-related protein Rab-28; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-28 isoform 1; ras-related protein Rab-28", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340); cone-rod dystrophy 18 (Disease Ontology:DOID:0111024)", "pathway": " (mmu:100972)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27929607;30228185;31219806;34428180", "class_list": "", "function": "Rab28 is a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (PubMed:30228185). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; These findings reveal that RAB28 is required for shedding and phagocytosis of cone OS discs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0035253 ciliary rootlet;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99KL7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPX8-1", "uniprot_id": [ { "id": "QCR10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPX8", "type": "external" } ], "mass": 6539.0, "length": 56, "protein_name": "Cytochrome b-c1 complex subunit 10", "gene_name": "Uqcr11", "organism": "Mouse", "refseq_name": "cytochrome b-c1 complex subunit 10", "refseq_ac": [ { "id": "NP_079926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079926", "type": "external" } ], "gene_names_uniprotkb": "Uqcr11; Uqcr", "gene_names_refseq": "0710008D09Rik; Uqcr11; Uqcr", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 10; Complex III subunit 10; Complex III subunit XI; Ubiquinol-cytochrome c reductase complex 6.4 kDa protein", "protein_names_refseq": "complex III subunit 10; complex III subunit XI; cytochrome b-c1 complex subunit 10; ubiquinol-cytochrome c reductase (6.4kD) subunit; ubiquinol-cytochrome c reductase complex 6.4 kDa protein; ubiquinol-cytochrome c reductase subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:66594); (R-MMU-611105); (R-MMU-9865881)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "19026783;30779550;32152506;34428180;34616041;38459019;38575788", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability., [UniProtKB, PubMed, PubMed]; N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFX1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9CPX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZ15-1", "uniprot_id": [ { "id": "PSF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZ15", "type": "external" } ], "mass": 22893.0, "length": 196, "protein_name": "DNA replication complex GINS protein PSF1", "gene_name": "Gins1", "organism": "Mouse", "refseq_name": "DNA replication complex GINS protein PSF1 isoform 1", "refseq_ac": [ { "id": "NP_081290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081290", "type": "external" } ], "gene_names_uniprotkb": "Gins1; Psf1", "gene_names_refseq": "2810418N01Rik; Gins1; Gins4; PSF1; mKIAA0186", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF1; GINS complex subunit 1", "protein_names_refseq": "DNA replication complex GINS protein PSF1 isoform 1; DNA replication complex GINS protein PSF1; GINS complex subunit 1 (Psf1 homolog); GINS complex subunit 4 (Sld5 homolog)", "tax_id": 10090, "disease": "immunodeficiency 55 (Disease Ontology:DOID:0111993)", "pathway": " (mmu:69270); (R-MMU-176974)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17127213;20103637;25605945;34428180", "class_list": "", "function": "Expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts as a gene responsive to transcription factor E2F1, [RefSeq, PubMed]; Findings implicate PSF1 in tumorigenesis and offer initial evidence of its potential as a theranostic target., [RefSeq, PubMed]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:1902983 DNA strand elongation involved in mitotic DNA replication;GO:0001833 inner cell mass cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CZ15-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZH3-1", "uniprot_id": [ { "id": "PSMG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZH3", "type": "external" } ], "mass": 13331.0, "length": 122, "protein_name": "Proteasome assembly chaperone 3", "gene_name": "Psmg3", "organism": "Mouse", "refseq_name": "proteasome assembly chaperone 3", "refseq_ac": [ { "id": "NP_079880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079880", "type": "external" } ], "gene_names_uniprotkb": "Psmg3; Pac3", "gene_names_refseq": "1810042K04Rik; 4930403H09Rik; Pba3; Psmg3", "protein_names_uniprotkb": "Proteasome assembly chaperone 3; PAC-3; Pba3; Proteasome chaperone homolog 3; mPAC3", "protein_names_refseq": "PAC-3; mPAC3; proteasome assembly chaperone 3; proteasome chaperone homolog 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66506); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17707236", "class_list": "", "function": "Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0043248 proteasome assembly;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0P5-1", "uniprot_id": [ { "id": "PYGO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0P5", "type": "external" } ], "mass": 45090.0, "length": 417, "protein_name": "Pygopus homolog 1", "gene_name": "Pygo1", "organism": "Mouse", "refseq_name": "pygopus homolog 1", "refseq_ac": [ { "id": "NP_082392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082392", "type": "external" } ], "gene_names_uniprotkb": "Pygo1", "gene_names_refseq": "2600014C22Rik; Pygo1", "protein_names_uniprotkb": "Pygopus homolog 1", "protein_names_refseq": "pygopus homolog 1", "tax_id": 10090, "disease": "heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (mmu:72135); (R-MMU-201722)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17425782;17499269;33635162", "class_list": "", "function": "In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity Publication Status: Online-Only, [RefSeq, PubMed]; Involved in signal transduction through the Wnt pathway., [UniProtKB]; Pygo1 regulates pathological cardiac hypertrophy via a beta-catenin-dependent mechanism., [RefSeq, PubMed]; These results suggest that the Pygopus1 plant homeodomain (PHD) dimerization is functionally important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001822 kidney development;GO:0007286 spermatid development;GO:0034504 protein localization to nucleus;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0P5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9M0-1", "uniprot_id": [ { "id": "PRS52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9M0", "type": "external" } ], "mass": 35883.0, "length": 321, "protein_name": "Serine protease 52", "gene_name": "Prss52", "organism": "Mouse", "refseq_name": "serine protease 52 precursor", "refseq_ac": [ { "id": "NP_082801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082801", "type": "external" } ], "gene_names_uniprotkb": "Prss52; Tesp3", "gene_names_refseq": "1700049K14Rik; Prss52; Tesp3", "protein_names_uniprotkb": "Serine protease 52; 3.4.21.-; Testicular-specific serine protease 3", "protein_names_refseq": "protease, serine 52; serine protease 52 precursor; testicular serine protease 3; testicular-specific serine protease 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73382)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable serine protease., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8C1Y0;Q80Y38", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D9M0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAW6-1", "uniprot_id": [ { "id": "PRP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAW6", "type": "external" } ], "mass": 58370.0, "length": 521, "protein_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "gene_name": "Prpf4", "organism": "Mouse", "refseq_name": "U4/U6 small nuclear ribonucleoprotein Prp4", "refseq_ac": [ { "id": "NP_081573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081573", "type": "external" } ], "gene_names_uniprotkb": "Prpf4", "gene_names_refseq": "1600015H11Rik; Prpf4; bN189G18.1", "protein_names_uniprotkb": "U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4", "protein_names_refseq": "U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4", "tax_id": 10090, "disease": "retinitis pigmentosa 70 (Disease Ontology:DOID:0110392); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (mmu:70052); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "23806337;29187734;34428180;35820727;39627609", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0015030 Cajal body;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9DAW6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DC48-1", "uniprot_id": [ { "id": "PRP17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DC48", "type": "external" } ], "mass": 65461.0, "length": 579, "protein_name": "Pre-mRNA-processing factor 17", "gene_name": "Cdc40", "organism": "Mouse", "refseq_name": "pre-mRNA-processing factor 17", "refseq_ac": [ { "id": "NP_082155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082155", "type": "external" } ], "gene_names_uniprotkb": "Cdc40; Prp17; Prpf17", "gene_names_refseq": "1200003H23Rik; Cdc40; EHB3; PRP17", "protein_names_uniprotkb": "Pre-mRNA-processing factor 17; Cell division cycle 40 homolog; PRP17 homolog", "protein_names_refseq": "PRP17 homolog; cell division cycle 40 homolog; pre-mRNA-processing factor 17", "tax_id": 10090, "disease": "pontocerebellar hypoplasia type 15 (Disease Ontology:DOID:0112326)", "pathway": " (mmu:71713); (R-MMU-159236); (R-MMU-72163); (R-MMU-72187); (R-MMU-9770562)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "31219806;33220177;34428180", "class_list": "", "function": "Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly., [RefSeq, PubMed]; Required for pre-mRNA splicing as component of the activated spliceosome (By similarity). Plays an important role in embryonic brain development; this function does not require proline peptide bond isomerization (PubMed:33220177)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RY33", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:1990403 embryonic brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9DC48-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI38-1", "uniprot_id": [ { "id": "PUS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JI38", "type": "external" } ], "mass": 55546.0, "length": 481, "protein_name": "tRNA pseudouridine(38/39) synthase", "gene_name": "Pus3", "organism": "Mouse", "refseq_name": "tRNA pseudouridine(38/39) synthase", "refseq_ac": [ { "id": "NP_075781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075781", "type": "external" } ], "gene_names_uniprotkb": "Pus3", "gene_names_refseq": "2610020J05Rik; 5730412F04Rik; Pus3", "protein_names_uniprotkb": "tRNA pseudouridine(38/39) synthase; 5.4.99.45; tRNA pseudouridine synthase 3; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3", "protein_names_refseq": "tRNA pseudouridine synthase 3; tRNA pseudouridine(38/39) synthase; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:67049)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11027153;17170069;34428180", "class_list": "", "function": "Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs. Also acts on position 38, but much less efficiently., [UniProtKB, PubMed]; Pus1p- and Pus3p-dependent pseudouridylation of SRA controls a coactivator-corepressor switch in SRA with major consequences for NR signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BVA6;Q8K0Y3", "ec_number_list": [ { "id": "5.4.99.45", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.45", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity;GO:0160154 tRNA pseudouridine(38/39) synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK23-1", "uniprot_id": [ { "id": "PSMG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JK23", "type": "external" } ], "mass": 33104.0, "length": 289, "protein_name": "Proteasome assembly chaperone 1", "gene_name": "Psmg1", "organism": "Mouse", "refseq_name": "proteasome assembly chaperone 1", "refseq_ac": [ { "id": "NP_062410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062410", "type": "external" } ], "gene_names_uniprotkb": "Psmg1; Dscr2", "gene_names_refseq": "Dscr2; Psmg1", "protein_names_uniprotkb": "Proteasome assembly chaperone 1; Down syndrome critical region protein 2 homolog", "protein_names_refseq": "Down syndrome critical region homolog 2; down syndrome critical region protein 2 homolog; proteasome assembly chaperone 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:56088); (R-MMU-9907900)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10872820;21750661", "class_list": "", "function": "Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BU12", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0021930 cerebellar granule cell precursor proliferation;GO:0080129 proteasome core complex assembly;GO:0051131 chaperone-mediated protein complex assembly;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JK23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKM7-1", "uniprot_id": [ { "id": "RAB37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKM7", "type": "external" } ], "mass": 24656.0, "length": 223, "protein_name": "Ras-related protein Rab-37", "gene_name": "Rab37", "organism": "Mouse", "refseq_name": "ras-related protein Rab-37 isoform 1", "refseq_ac": [ { "id": "NP_067386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067386", "type": "external" } ], "gene_names_uniprotkb": "Rab37", "gene_names_refseq": "B230331O03Rik; B230354I04Rik; Rab37", "protein_names_uniprotkb": "Ras-related protein Rab-37; 3.6.5.2", "protein_names_refseq": "GTPase Rab37; RAB37, member of RAS oncogene family; ras-related protein Rab-37 isoform 1; ras-related protein Rab-37", "tax_id": 10090, "disease": "", "pathway": " (mmu:58222); (R-MMU-6798695); (R-MMU-8873719)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10722846;12578829;34428180;36457117;36627432;37151129;38321486;38536817", "class_list": "", "function": "Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90alpha and TIMP1., [RefSeq, PubMed]; Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Secretory autophagy-promoted cargo exocytosis requires active RAB37., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38536817). Acts as an organizer for autophagosome biogenesis in a GTP-dependent manner (PubMed:38536817). Involved in retinal homeostasis by autophagy regulation (PubMed:38536817)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7E1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0015031 protein transport;GO:0010508 positive regulation of autophagy;GO:0017157 regulation of exocytosis;GO:0042478 regulation of eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JKM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QVY8-1", "uniprot_id": [ { "id": "RAI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QVY8", "type": "external" } ], "mass": 57123.0, "length": 529, "protein_name": "Retinoic acid-induced protein 2", "gene_name": "Rai2", "organism": "Mouse", "refseq_name": "retinoic acid-induced protein 2", "refseq_ac": [ { "id": "NP_001096837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096837", "type": "external" } ], "gene_names_uniprotkb": "Rai2", "gene_names_refseq": "3f8; Rai2", "protein_names_uniprotkb": "Retinoic acid-induced protein 2; 3f8", "protein_names_refseq": "retinoic acid-induced protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:24004)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8314004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UPL8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QVY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1X2-1", "uniprot_id": [ { "id": "PTSS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1X2", "type": "external" } ], "mass": 55021.0, "length": 473, "protein_name": "Phosphatidylserine synthase 2", "gene_name": "Ptdss2", "organism": "Mouse", "refseq_name": "phosphatidylserine synthase 2 isoform 1", "refseq_ac": [ { "id": "NP_038810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038810", "type": "external" } ], "gene_names_uniprotkb": "Ptdss2; Pss2", "gene_names_refseq": "PSS2; Ptdss2", "protein_names_uniprotkb": "Phosphatidylserine synthase 2; 2.7.8.29; PSS-2; PtdSer synthase 2; Serine-exchange enzyme II", "protein_names_refseq": "PSS-2; phosphatidylserine synthase 2 isoform 1; ptdSer synthase 2; serine-exchange enzyme II", "tax_id": 10090, "disease": "", "pathway": " (mmu:27388); (R-MMU-1483101)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10432300;10938271;12361952;18343815;21183079;21750661;23071296", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:12361952, PubMed:23071296). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:10938271, PubMed:23071296). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; PSS2 may play a key role in PS accumulation in brain and testis through high activity toward DHA-containing substrates that are abundant in these tissues, [RefSeq, PubMed]; Pss2 is responsible for the majority of serine exchange activity in in vitro assays, but a deficiency in this enzyme does not cause perturbations in phospholipid content or severe developmental abnormalities, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9562, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHL2;Q8CCI8;Q8CCY7;Q922A1;Q9CY68", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z1X2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ06-1", "uniprot_id": [ { "id": "RM24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ06", "type": "external" } ], "mass": 24945.0, "length": 216, "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "Mrpl24", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL24m precursor", "refseq_ac": [ { "id": "NP_080867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080867", "type": "external" } ], "gene_names_uniprotkb": "Mrpl24", "gene_names_refseq": "2010005E08Rik; 2810470K06Rik; 6720473G22Rik; Mrpl24", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24m; 39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24", "protein_names_refseq": "39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24; large ribosomal subunit protein uL24m precursor; large ribosomal subunit protein uL24m", "tax_id": 10090, "disease": "", "pathway": " (mmu:67707); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;31599954;34428180;36288343", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CX51;Q9D1L7;Q9D7R6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TND5-1", "uniprot_id": [ { "id": "RPF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TND5", "type": "external" } ], "mass": 40037.0, "length": 349, "protein_name": "Ribosome production factor 1", "gene_name": "Rpf1", "organism": "Mouse", "refseq_name": "ribosome production factor 1 isoform 1", "refseq_ac": [ { "id": "NP_081608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081608", "type": "external" } ], "gene_names_uniprotkb": "Rpf1; Bxdc5", "gene_names_refseq": "2210420E24Rik; 2310066N05Rik; Bxdc5; Rpf1", "protein_names_uniprotkb": "Ribosome production factor 1; Brix domain-containing protein 5; Ribosome biogenesis protein RPF1", "protein_names_refseq": "RNA processing factor 1; brix domain containing 5; brix domain-containing protein 5; ribosome biogenesis protein RPF1; ribosome production factor 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70285)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;29187734;31219806", "class_list": "", "function": "May be required for ribosome biogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBS4;Q5EBN9;Q8K343", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TND5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97304-1", "uniprot_id": [ { "id": "RPAC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97304", "type": "external" } ], "mass": 15072.0, "length": 133, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC2", "gene_name": "Polr1d", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1", "refseq_ac": [ { "id": "NP_033113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033113", "type": "external" } ], "gene_names_uniprotkb": "Polr1d; Rpo1-3", "gene_names_refseq": "1110003G10Rik; AC19; Polr1d; RPA16; Rpo1-3", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC2; AC19; DNA-directed RNA polymerase I subunit D; RNA polymerase I 16 kDa subunit; RNA polymerases I and III subunit AC2; RPA16", "protein_names_refseq": "DNA-directed RNA polymerase I 16 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1; DNA-directed RNA polymerases I and III subunit RPAC2; RNA polymerase 1-3; RNA polymerases I and III subunit AC2", "tax_id": 10090, "disease": "Treacher Collins syndrome 2 (Disease Ontology:DOID:0080790); leukodystrophy (Disease Ontology:DOID:10579); Treacher Collins syndrome (Disease Ontology:DOID:2908); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:20018)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;33022126;8955128", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB]; Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice., [RefSeq, PubMed]; This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97304-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BP31-1", "uniprot_id": [ { "id": "RN122_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BP31", "type": "external" } ], "mass": 17448.0, "length": 155, "protein_name": "RING finger protein 122", "gene_name": "Rnf122", "organism": "Mouse", "refseq_name": "RING finger protein 122 isoform 4", "refseq_ac": [ { "id": "NP_780345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780345", "type": "external" } ], "gene_names_uniprotkb": "Rnf122", "gene_names_refseq": "1110063C11Rik; Rnf122", "protein_names_uniprotkb": "RING finger protein 122", "protein_names_refseq": "RING finger protein 122 isoform 4; ring finger protein 122 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;27506794", "class_list": "", "function": "May induce necrosis and apoptosis. May play a role in cell viability (By similarity)., [UniProtKB]; RNF122 suppresses antiviral type I interferon production by targeting RIG-I caspase activation and recruitment domains to mediate RIG-I degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VA7;Q8BGD3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010917 negative regulation of mitochondrial membrane potential;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BP31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMV1-1", "uniprot_id": [ { "id": "RN139_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMV1", "type": "external" } ], "mass": 76185.0, "length": 668, "protein_name": "E3 ubiquitin-protein ligase RNF139", "gene_name": "Rnf139", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF139", "refseq_ac": [ { "id": "NP_780435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435", "type": "external" } ], "gene_names_uniprotkb": "Rnf139", "gene_names_refseq": "4930555P18Rik; Rnf139", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF139; 2.3.2.27; RING finger protein 139; RING-type E3 ubiquitin transferase RNF139; Translocation in renal carcinoma on chromosome 8 protein", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF139; RING-type E3 ubiquitin transferase RNF139; translocation in renal carcinoma on chromosome 8 protein", "tax_id": 10090, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (mmu:75841)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17242355;21183079;21750661;25428506;25605945;30084848;31599954;34428180", "class_list": "", "function": "E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZU9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0019787 ubiquitin-like protein transferase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system;GO:0036513 Derlin-1 retrotranslocation complex", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0008285 negative regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q7TMV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56716-1", "uniprot_id": [ { "id": "RP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P56716", "type": "external" } ], "mass": 234388.0, "length": 2095, "protein_name": "Oxygen-regulated protein 1", "gene_name": "Rp1", "organism": "Mouse", "refseq_name": "oxygen-regulated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_035413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035413", "type": "external" } ], "gene_names_uniprotkb": "Rp1; Orp1; Rp1h", "gene_names_refseq": "Dcdc3; Gm38717; Orp1; Rp1h; Rp1; mG145", "protein_names_uniprotkb": "Oxygen-regulated protein 1; Retinitis pigmentosa RP1 protein homolog", "protein_names_refseq": "lipoxygenase homology domain-containing protein 1; oxygen-regulated protein 1 isoform 1; oxygen-regulated protein 1; retinitis pigmentosa 1 homolog; retinitis pigmentosa RP1 protein homolog", "tax_id": 10090, "disease": "retinitis pigmentosa 1 (Disease Ontology:DOID:0110390)", "pathway": " (mmu:19888)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10391211;11773008;11960024;14507858;15269252;16126734;19657028;21148103;21750661", "class_list": "", "function": "Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jun 2019]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q548Q8", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005929 cilium;GO:0001917 photoreceptor inner segment;GO:0005875 microtubule associated complex;GO:0005930 axoneme", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0060042 retina morphogenesis in camera-type eye;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P56716-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35972-1", "uniprot_id": [ { "id": "RM23_MOUSE", "url": "https://www.uniprot.org/uniprot/O35972", "type": "external" } ], "mass": 17122.0, "length": 146, "protein_name": "Large ribosomal subunit protein uL23m", "gene_name": "Mrpl23", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL23m isoform 2", "refseq_ac": [ { "id": "NP_035418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035418", "type": "external" } ], "gene_names_uniprotkb": "Mrpl23; L23mrp", "gene_names_refseq": "L23mrp; Mrpl23; Rpl23l; Rpl23", "protein_names_uniprotkb": "Large ribosomal subunit protein uL23m; 39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; L23mt; MRP-L23", "protein_names_refseq": "39S ribosomal protein L23, mitochondrial; L23 mitochondrial-related protein; L23mt; MRP-L23; large ribosomal subunit protein uL23m isoform 2; large ribosomal subunit protein uL23m", "tax_id": 10090, "disease": "", "pathway": " (mmu:19935); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11279069;21750661;9337391;9344651", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78E46", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0001650 fibrillar center;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78DX7-1", "uniprot_id": [ { "id": "ROS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78DX7", "type": "external" } ], "mass": 261967.0, "length": 2340, "protein_name": "Proto-oncogene tyrosine-protein kinase ROS", "gene_name": "Ros1", "organism": "Mouse", "refseq_name": "proto-oncogene tyrosine-protein kinase ROS precursor", "refseq_ac": [ { "id": "NP_035412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035412", "type": "external" } ], "gene_names_uniprotkb": "Ros1; Ros-1; Ros", "gene_names_refseq": "Ros-1; Ros1; c-ros", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase ROS; 2.7.10.1; Proto-oncogene c-Ros-1; Proto-oncogene c-Ros; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase", "protein_names_refseq": "Ros1 proto-oncogene; c-Ros receptor tyrosine kinase; c-ros-1; proto-oncogene c-Ros-1; proto-oncogene tyrosine-protein kinase ROS precursor; proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19886)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11266449;11799110;21750661;32499443;7970722;8544427;8657124;8675006;9774423", "class_list": "", "function": "Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (PubMed:32499443). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q60705", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019903 protein phosphatase binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048471 perinuclear region of cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0010966 regulation of phosphate transport;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q78DX7-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBG6-1", "uniprot_id": [ { "id": "RPN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBG6", "type": "external" } ], "mass": 69063.0, "length": 631, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2", "gene_name": "Rpn2", "organism": "Mouse", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_062616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062616", "type": "external" } ], "gene_names_uniprotkb": "Rpn2", "gene_names_refseq": "1300012C06Rik; Rpn-2; Rpn2", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; RPN-II; Ribophorin II; Ribophorin-2", "protein_names_refseq": "RPN-II; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; ribophorin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:20014); (R-MMU-9768727); (R-MMU-9931295)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;25605945;28528544;30899004;31219806;32783947;33300544;34203471;34428180;36210013;37453647;37828378;38551359;40997131", "class_list": "glycogene", "function": "Leu promotes C2C12 cell differentiation by regulating the GSK3beta/beta-catenin signaling pathway through facilitating the interaction between SESN2 and RPN2., [RefSeq, PubMed]; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 45, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ACG6;Q3TKY0;Q91XH0", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016604 nuclear body;GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9DBG6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.100.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D241-1", "uniprot_id": [ { "id": "RN186_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D241", "type": "external" } ], "mass": 24704.0, "length": 226, "protein_name": "E3 ubiquitin-protein ligase RNF186", "gene_name": "Rnf186", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf186", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF186; 2.3.2.27; RING finger protein 186", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:66825)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;33280498;34623328", "class_list": "", "function": "E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens (PubMed:34623328). Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498). Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78R58", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D241-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70700-1", "uniprot_id": [ { "id": "RPA2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70700", "type": "external" } ], "mass": 128213.0, "length": 1135, "protein_name": "DNA-directed RNA polymerase I subunit RPA2", "gene_name": "Polr1b", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA2", "refseq_ac": [ { "id": "NP_033112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033112", "type": "external" } ], "gene_names_uniprotkb": "Polr1b; Rpa2; Rpo1-2", "gene_names_refseq": "128kDa; D630020H17Rik; Polr1b; RPA116; RPA135; RPA2; Rpo1-2", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA2; 2.7.7.6; DNA-directed RNA polymerase I 135 kDa polypeptide; RNA polymerase I subunit 2; RPA135", "protein_names_refseq": "DNA-directed RNA polymerase I 135 kDa polypeptide; DNA-directed RNA polymerase I 135kDa polypeptide; DNA-directed RNA polymerase I subunit RPA2; RNA polymerase 1-2, 128 kDa subunit; RNA polymerase I subunit 2", "tax_id": 10090, "disease": "Treacher Collins syndrome 4 (Disease Ontology:DOID:0080792); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (mmu:20017); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "21750661;25428506;30084848;30272023;30746471;30779550;30949703;31219806;34428180;8921381", "class_list": "", "function": "Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (By similarity). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol I active center together with the largest subunit POLR1A/RPA1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMX7", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0032549 ribonucleoside binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0071667 DNA/RNA hybrid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0014029 neural crest formation;GO:0017126 nucleologenesis;GO:0009303 rRNA transcription;GO:0007566 embryo implantation;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70700-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7RDN6-1", "uniprot_id": [ { "id": "RNLS_MOUSE", "url": "https://www.uniprot.org/uniprot/A7RDN6", "type": "external" } ], "mass": 37597.0, "length": 342, "protein_name": "Renalase", "gene_name": "Rnls", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnls", "gene_names_refseq": "", "protein_names_uniprotkb": "Renalase; 1.6.3.5; MAO-C; Monoamine oxidase-C; mMAO-C", "protein_names_refseq": "", "tax_id": 10090, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); stroke (Disease Ontology:DOID:0051061); interstitial nephritis (Disease Ontology:DOID:1063); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (R-MMU-196807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17846919;34428180", "class_list": "", "function": "Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TD88;Q80W75", "ec_number_list": [ { "id": "1.6.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.5", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0051379 epinephrine binding;GO:0016491 oxidoreductase activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0070404 NADH binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045776 negative regulation of blood pressure;GO:0060047 heart contraction;GO:0010459 negative regulation of heart rate;GO:0042417 dopamine metabolic process;GO:0042415 norepinephrine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7RDN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D773-1", "uniprot_id": [ { "id": "RM02_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D773", "type": "external" } ], "mass": 33341.0, "length": 306, "protein_name": "Large ribosomal subunit protein uL2m", "gene_name": "Mrpl2", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL2m isoform 2", "refseq_ac": [ { "id": "NP_001303671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303671", "type": "external" } ], "gene_names_uniprotkb": "Mrpl2", "gene_names_refseq": "CGI-22; L2mt; MRP-L14; MRP-L2; Mrpl2; Rpml14", "protein_names_uniprotkb": "Large ribosomal subunit protein uL2m; 39S ribosomal protein L2, mitochondrial; L2mt; MRP-L2", "protein_names_refseq": "39S ribosomal protein L2, mitochondrial; large ribosomal subunit protein uL2m isoform 2; large ribosomal subunit protein uL2m; ribosomal protein, mitochondrial, L14", "tax_id": 10090, "disease": "", "pathway": " (mmu:27398); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D773-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKG6-1", "uniprot_id": [ { "id": "RNT2B_MOUSE", "url": "https://www.uniprot.org/uniprot/C0HKG6", "type": "external" } ], "mass": 29609.0, "length": 259, "protein_name": "Ribonuclease T2-B", "gene_name": "Rnaset2b", "organism": "Mouse", "refseq_name": "ribonuclease T2-B precursor", "refseq_ac": [ { "id": "NP_080887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080887", "type": "external" } ], "gene_names_uniprotkb": "Rnaset2b", "gene_names_refseq": "0610007O07Rik; 4833423A10Rik; 4930532K22Rik; C79750; RNASE6PL; Rnaset2b; Rnaset2", "protein_names_uniprotkb": "Ribonuclease T2-B; 4.6.1.19; Ribonuclease 6-B", "protein_names_refseq": "ribonuclease 6-B; ribonuclease T2-B precursor; ribonuclease T2-B; ribonuclease T2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100037283); (mmu:68195); (R-MMU-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CQ01", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0004540 RNA nuclease activity;GO:0004521 RNA endonuclease activity;GO:0033897 ribonuclease T2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005758 mitochondrial intermembrane space;GO:0005788 endoplasmic reticulum lumen;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "C0HKG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0C0-1", "uniprot_id": [ { "id": "RPC7L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0C0", "type": "external" } ], "mass": 25136.0, "length": 218, "protein_name": "DNA-directed RNA polymerase III subunit RPC7-like", "gene_name": "Polr3gl", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC7-like isoform 1", "refseq_ac": [ { "id": "NP_081517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081517", "type": "external" } ], "gene_names_uniprotkb": "Polr3gl", "gene_names_refseq": "2010003I19Rik; Polr3gl", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC7-like; DNA-directed RNA polymerase III subunit G-like; RNA polymerase III subunit C7-like", "protein_names_refseq": "DNA-directed RNA polymerase III subunit G-like; DNA-directed RNA polymerase III subunit RPC7-like isoform 1; DNA-directed RNA polymerase III subunit RPC7-like; RNA polymerase III subunit C7-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:69870); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;24107381;25428506", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D8G0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R0C0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08740-1", "uniprot_id": [ { "id": "RPB11_MOUSE", "url": "https://www.uniprot.org/uniprot/O08740", "type": "external" } ], "mass": 13251.0, "length": 117, "protein_name": "DNA-directed RNA polymerase II subunit RPB11", "gene_name": "Polr2j", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Polr2j; Rpo2-4", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB11; DNA-directed RNA polymerase II subunit J; RNA polymerase II 13.3 kDa subunit; RNA polymerase II subunit B11; RPB14", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 21, "publication_count": 2, "publication_id_list": "21750661;9099876", "class_list": "", "function": "Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0030275 LRR domain binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08740-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Q5-1", "uniprot_id": [ { "id": "RM40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2Q5", "type": "external" } ], "mass": 24301.0, "length": 206, "protein_name": "Large ribosomal subunit protein mL40", "gene_name": "Mrpl40", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL40 precursor", "refseq_ac": [ { "id": "NP_035052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035052", "type": "external" } ], "gene_names_uniprotkb": "Mrpl40; Nlvcf", "gene_names_refseq": "Mrpl40; Nlvcf", "protein_names_uniprotkb": "Large ribosomal subunit protein mL40; 39S ribosomal protein L40, mitochondrial; L40mt; MRP-L40; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog", "protein_names_refseq": "39S ribosomal protein L40, mitochondrial; L40mt; MRP-L40; large ribosomal subunit protein mL40 precursor; large ribosomal subunit protein mL40; nuclear localization signal protein absent in velo-cardio-facial patients; nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog", "tax_id": 10090, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (mmu:18100); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;27184122;34678516;35820727;9790763", "class_list": "", "function": "Two-photon imaging of the genetically encoded fluorescent calcium indicator GCaMP6, expressed in presynaptic cytosol or mitochondria, showed that Mrpl40 haploinsufficiency deregulates STP via impaired calcium extrusion from the mitochondrial matrix through the mitochondrial permeability transition pore., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CS52", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z2Q5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52432-1", "uniprot_id": [ { "id": "RPAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52432", "type": "external" } ], "mass": 39107.0, "length": 346, "protein_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "gene_name": "Polr1c", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I and III subunit RPAC1", "refseq_ac": [ { "id": "NP_033111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033111", "type": "external" } ], "gene_names_uniprotkb": "Polr1c; Rpo1-1", "gene_names_refseq": "40kDa; Polr1c; Polr1e; RPA40; Rpo1-1", "protein_names_uniprotkb": "DNA-directed RNA polymerases I and III subunit RPAC1; AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; RNA polymerases I and III subunit AC1; RPA40; RPC40", "protein_names_refseq": "AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; RNA polymerase 1-1 (40 kDa subunit); RNA polymerases I and III subunit AC1; RPC40", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 11 (Disease Ontology:DOID:0060792); Treacher Collins syndrome 3 (Disease Ontology:DOID:0080791); Treacher Collins syndrome (Disease Ontology:DOID:2908)", "pathway": " (mmu:20016); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21750661;31219806;34428180;7929437;9099876", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. POLR1C/RPAC1 is part of the polymerase core and may function as a clamp element that moves to open and close the cleft (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJZ9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001650 fibrillar center", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52432-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XF4-1", "uniprot_id": [ { "id": "RN167_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XF4", "type": "external" } ], "mass": 38014.0, "length": 347, "protein_name": "E3 ubiquitin-protein ligase RNF167", "gene_name": "Rnf167", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF167 isoform 1 precursor", "refseq_ac": [ { "id": "NP_081721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081721", "type": "external" } ], "gene_names_uniprotkb": "Rnf167", "gene_names_refseq": "0610010G05Rik; 5730408C10Rik; Rnf167", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF167; 2.3.2.27; RING finger protein 167", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF167 isoform 1 precursor; E3 ubiquitin-protein ligase RNF167; RING-type E3 ubiquitin transferase RNF167; novel PA domain and C3HC4 type zinc finger (RING finger) containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70510)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;22872234;23129617;25428506;26495903;26740625;28011936;30084848;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N., [UniProtKB, UniProtKB]; RNF167 is a selective regulator of AMPAR-mediated neurotransmission., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3U4S5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0031669 cellular response to nutrient levels;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91XF4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YQ7-1", "uniprot_id": [ { "id": "RMD5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YQ7", "type": "external" } ], "mass": 44421.0, "length": 393, "protein_name": "E3 ubiquitin-protein transferase RMND5B", "gene_name": "Rmnd5b", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein transferase RMND5B", "refseq_ac": [ { "id": "NP_079622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079622", "type": "external" } ], "gene_names_uniprotkb": "Rmnd5b", "gene_names_refseq": "0610039K22Rik; Gid2; Rmnd5b", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase RMND5B; 2.3.2.27; Protein RMD5 homolog B", "protein_names_refseq": "E3 ubiquitin-protein transferase RMND5B; protein RMD5 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:66089); (R-MMU-9861718)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034657 GID complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91YQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BKF1-1", "uniprot_id": [ { "id": "RPOM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BKF1", "type": "external" } ], "mass": 136705.0, "length": 1207, "protein_name": "DNA-directed RNA polymerase, mitochondrial", "gene_name": "Polrmt", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_766139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766139", "type": "external" } ], "gene_names_uniprotkb": "Polrmt", "gene_names_refseq": "1110018N15Rik; 4932416K13; Polrmt; mtRPOL", "protein_names_uniprotkb": "DNA-directed RNA polymerase, mitochondrial; 2.7.7.6; MtRPOL", "protein_names_refseq": "DNA-directed RNA polymerase, mitochondrial isoform 2 precursor; DNA-directed RNA polymerase, mitochondrial; mitochondrial DNA-directed RNA polymerase", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 55 (Disease Ontology:DOID:0070428)", "pathway": " (mmu:216151); (R-MMU-163282); (R-MMU-9913635)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15526033;21750661;23283301;31219806;34428180;36210013;38649537", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Has DNA primase activity. Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL)., [UniProtKB, UniProtKB]; POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition, [RefSeq, PubMed]; SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJE0", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0003899 DNA-directed RNA polymerase activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0034245 mitochondrial DNA-directed RNA polymerase complex;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006391 transcription initiation at mitochondrial promoter;GO:0006390 mitochondrial transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BKF1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZV0-1", "uniprot_id": [ { "id": "RNH2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZV0", "type": "external" } ], "mass": 34729.0, "length": 308, "protein_name": "Ribonuclease H2 subunit B", "gene_name": "Rnaseh2b", "organism": "Mouse", "refseq_name": "ribonuclease H2 subunit B", "refseq_ac": [ { "id": "NP_080277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080277", "type": "external" } ], "gene_names_uniprotkb": "Rnaseh2b; Dleu8", "gene_names_refseq": "1110019N06Rik; 2610207P08Rik; Dleu8; Rnaseh2b", "protein_names_uniprotkb": "Ribonuclease H2 subunit B; Deleted in lymphocytic leukemia 8 homolog; RNase H2 subunit B; Ribonuclease HI subunit B", "protein_names_refseq": "RNase H2 subunit B; deleted in lymphocytic leukemia 8 homolog; ribonuclease H2 subunit B; ribonuclease HI subunit B", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (mmu:67153)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "18250455;19923215;20173027;21750661;22579044;23744109;25428506;27802388;30084848;30779550;34428180", "class_list": "", "function": "Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs., [RefSeq, PubMed]; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB, PubMed]; Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review] Review article, [RefSeq, PubMed]; Study performed targeted mutagenesis of the mouse Rnaseh2b gene to gain insight into the in vivo role of the mammalian RNase H2 enzyme. Ablation of Rnaseh2b in mice leads to early embryonic lethality due to elevated DNA damage and reduced cellular proliferation during gastrulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D014", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0009259 ribonucleotide metabolic process;GO:0001701 in utero embryonic development;GO:0010629 negative regulation of gene expression;GO:0010389 regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80ZV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3A7-1", "uniprot_id": [ { "id": "RN207_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3A7", "type": "external" } ], "mass": 70759.0, "length": 635, "protein_name": "RING finger protein 207", "gene_name": "Rnf207", "organism": "Mouse", "refseq_name": "RING finger protein 207", "refseq_ac": [ { "id": "NP_001028661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028661", "type": "external" } ], "gene_names_uniprotkb": "Rnf207; Gm143", "gene_names_refseq": "D330010C22Rik; Gm143; Rnf207", "protein_names_uniprotkb": "RING finger protein 207", "protein_names_refseq": "RING finger protein 207", "tax_id": 10090, "disease": "", "pathway": " (mmu:433809)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;27677939;35352799", "class_list": "", "function": "Our findings indicate that RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure., [RefSeq, PubMed]; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PW94", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding;GO:0044325 transmembrane transporter binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0055117 regulation of cardiac muscle contraction;GO:1901207 regulation of heart looping;GO:1905026 positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3V3A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q555-1", "uniprot_id": [ { "id": "RN213_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q555", "type": "external" } ], "mass": 584258.0, "length": 5148, "protein_name": "E3 ubiquitin-protein ligase RNF213", "gene_name": "Rnf213", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF213", "refseq_ac": [ { "id": "NP_001035094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035094", "type": "external" } ], "gene_names_uniprotkb": "Rnf213; Mystr", "gene_names_refseq": "6030403J01; D11Ertd759e; Rnf213; mysterin", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF213; 2.3.2.-; 2.3.2.27; 3.6.4.-; E3 ubiquitin-lipopolysaccharide ligase RNF213; Mysterin; RING finger protein 213", "protein_names_refseq": "E3 ubiquitin-lipopolysaccharide ligase RNF213; E3 ubiquitin-protein ligase RNF213; RING-type E3 ubiquitin transferase RNF213", "tax_id": 10090, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); Moyamoya disease (Disease Ontology:DOID:13099)", "pathway": " (mmu:672511); (R-MMU-983168)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "21750661;23410753;24440776;25383461;25446450;26126547;26315378;32573437;33420513;34012115;34418053;34599178;37399508;37438553;37507081;37778692;39927985", "class_list": "", "function": "Angiogenesis was enhanced in mice lacking RNF213 after chronic hind-limb ischemia, which suggested the potential role of the RNF213 abnormality in the development of pathological vascular networks in chronic ischemia., [RefSeq, PubMed]; Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:32573437). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Also functions as an intracellular sensor for ISGylated proteins: upon type I interferon stimulation, undergoes ISGylation and oligomerizes on lipid droplets to form a binding platform for ISG15-modified substrate proteins, thereby acting as a broad-spectrum antimicrobial effector. Restricts intracellular bacterial pathogens in an ISG15-dependent manner by decorating the bacterial surface with ubiquitin to promote autophagic clearance (PubMed:34599178). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:32573437)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Functional loss of RNF213 did not sufficiently induce moyamoya disese. Suppression of vascular remodeling in RNF213-/- requires further examination to clarify the role of RNF213., [RefSeq, PubMed]; Knockout of Rnf213 Ameliorates Cerebral Ischemic-reperfusion Injury by Inhibiting Neuronal Apoptosis Through the Akt/GSK-3beta/beta-catenin/Bcl-2 Pathway., [RefSeq, PubMed]; RNF213 loss-of-function promotes pathological angiogenesis in moyamoya disease via the Hippo pathway., [RefSeq, PubMed]; Rnf-213 Knockout Induces Pericyte Reduction and Blood-Brain Barrier Impairment in Mouse., [RefSeq, PubMed]; These findings indicated that the disruption of Rnf213 improved glucose tolerance by protecting islet beta cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F7A6H4;Q8BVK6", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0019216 regulation of lipid metabolic process;GO:0016567 protein ubiquitination;GO:0098792 xenophagy;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "E9Q555-1", "record_type": "protein", "filter_code": "0000000.1100111.000100.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9Q7F2-1", "uniprot_id": [ { "id": "RN169_MOUSE", "url": "https://www.uniprot.org/uniprot/E9Q7F2", "type": "external" } ], "mass": 75796.0, "length": 694, "protein_name": "E3 ubiquitin-protein ligase RNF169", "gene_name": "Rnf169", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF169", "refseq_ac": [ { "id": "NP_780597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780597", "type": "external" } ], "gene_names_uniprotkb": "Rnf169; Kiaa1991", "gene_names_refseq": "2900057K09Rik; Rnf169", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF169; 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169", "tax_id": 10090, "disease": "", "pathway": " (mmu:108937)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;31219806;34428180", "class_list": "", "function": "Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z47", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "E9Q7F2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0Q7-1", "uniprot_id": [ { "id": "RM45_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0Q7", "type": "external" } ], "mass": 35411.0, "length": 306, "protein_name": "Large ribosomal subunit protein mL45", "gene_name": "Mrpl45", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL45", "refseq_ac": [ { "id": "NP_080203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080203", "type": "external" } ], "gene_names_uniprotkb": "Mrpl45", "gene_names_refseq": "2600005P05Rik; Mrpl45", "protein_names_uniprotkb": "Large ribosomal subunit protein mL45; 39S ribosomal protein L45, mitochondrial; L45mt; MRP-L45", "protein_names_refseq": "39S ribosomal protein L45, mitochondrial; L45mt; MRP-L45; large ribosomal subunit protein mL45", "tax_id": 10090, "disease": "atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (mmu:67036); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "Component of the mitochondrial large ribosomal subunit (mt-LSU). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunnel exit and position the exit at a distance from the membrane surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZL8;Q8VDW2", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D0Q7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ18-1", "uniprot_id": [ { "id": "RNH2C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ18", "type": "external" } ], "mass": 17823.0, "length": 166, "protein_name": "Ribonuclease H2 subunit C", "gene_name": "Rnaseh2c", "organism": "Mouse", "refseq_name": "ribonuclease H2 subunit C", "refseq_ac": [ { "id": "NP_080892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080892", "type": "external" } ], "gene_names_uniprotkb": "Rnaseh2c; Ayp1", "gene_names_refseq": "1500026D16Rik; AYP1; Rnaseh2c", "protein_names_uniprotkb": "Ribonuclease H2 subunit C; RNase H2 subunit C; Ribonuclease HI subunit C", "protein_names_refseq": "RNase H2 subunit C; ribonuclease H2 subunit C; ribonuclease HI subunit C", "tax_id": 10090, "disease": "Aicardi-Goutieres syndrome (Disease Ontology:DOID:0050629)", "pathway": " (mmu:68209)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19923215;21750661;23744109", "class_list": "", "function": "Data show that the interwoven architecture of RNase H2B and RNase H2C that interface with RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-protein interaction motifs., [RefSeq, PubMed]; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes., [UniProtKB, PubMed]; Recent evidence gathered from ribonuclease H2 knock-out mice provides insight into the molecular mechanisms underlying Aicardi-Goutieres syndrome development and a potential role of DNA damage as a trigger of autoimmunity is discussed. [review] Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1N2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0032299 ribonuclease H2 complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ18-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D5A9-1", "uniprot_id": [ { "id": "RNS10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D5A9", "type": "external" } ], "mass": 23407.0, "length": 208, "protein_name": "Inactive ribonuclease-like protein 10", "gene_name": "Rnase10", "organism": "Mouse", "refseq_name": "inactive ribonuclease-like protein 10 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001156335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156335", "type": "external" } ], "gene_names_uniprotkb": "Rnase10", "gene_names_refseq": "4930474F22Rik; Rah1; Rnase10", "protein_names_uniprotkb": "Inactive ribonuclease-like protein 10; Protein Train A", "protein_names_refseq": "RNase 10; inactive ribonuclease-like protein 10 isoform 2 precursor; inactive ribonuclease-like protein 10; protein train A; ribonuclease A family, member 10; ribonuclease A h1; ribonuclease-like protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:75019)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12920233;14561640;21750661;22750516", "class_list": "", "function": "Epididymal protein Rnase10 is required for post-testicular sperm maturation and male fertility., [RefSeq, PubMed]; Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6XL64", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0050830 defense response to Gram-positive bacterium;GO:0007338 single fertilization;GO:0008584 male gonad development;GO:0072520 seminiferous tubule development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D5A9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R040-1", "uniprot_id": [ { "id": "RPP21_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R040", "type": "external" } ], "mass": 17243.0, "length": 150, "protein_name": "Ribonuclease P protein subunit p21", "gene_name": "Rpp21", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p21", "refseq_ac": [ { "id": "NP_080584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080584", "type": "external" } ], "gene_names_uniprotkb": "Rpp21; Cat60", "gene_names_refseq": "0610037N01Rik; Rpp21", "protein_names_uniprotkb": "Ribonuclease P protein subunit p21; RNaseP protein p21; Ribonucleoprotein V", "protein_names_refseq": "RNaseP protein p21; ribonuclease P 21kDa subunit; ribonuclease P protein subunit p21; ribonucleoprotein V", "tax_id": 10090, "disease": "", "pathway": " (mmu:67676); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12671000;21750661;31219806", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80XY3;Q811B7;Q9CPX1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0009410 response to xenobiotic stimulus;GO:0001682 tRNA 5'-leader removal;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R040-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q791N7-1", "uniprot_id": [ { "id": "RPA12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q791N7", "type": "external" } ], "mass": 13650.0, "length": 123, "protein_name": "DNA-directed RNA polymerase I subunit RPA12", "gene_name": "Polr1h", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA12", "refseq_ac": [ { "id": "NP_075651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075651", "type": "external" } ], "gene_names_uniprotkb": "Polr1h; Rpa12; Znrd1", "gene_names_refseq": "1110014N07Rik; Polr1h; Rpa12; Znrd1", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA12; DNA-directed RNA polymerase I subunit H; Zinc ribbon domain-containing protein 1", "protein_names_refseq": "DNA-directed RNA polymerase I subunit H; DNA-directed RNA polymerase I subunit RPA12; nuclear RNA polymerase I small specific subunit; zinc ribbon domain containing 1; zinc ribbon domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66136); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "18250455;19224205;19892989;20173027;21750661;21952136;25428506;25428507;25605945;27802388;30084848;30779550;34428180;35820727", "class_list": "", "function": "Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005736 RNA polymerase I complex;GO:0005730 nucleolus;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0006362 transcription elongation by RNA polymerase I;GO:0006363 termination of RNA polymerase I transcription;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q791N7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1F9-1", "uniprot_id": [ { "id": "RPP40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1F9", "type": "external" } ], "mass": 41547.0, "length": 363, "protein_name": "Ribonuclease P protein subunit p40", "gene_name": "Rpp40", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p40 isoform 1", "refseq_ac": [ { "id": "NP_666050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666050", "type": "external" } ], "gene_names_uniprotkb": "Rpp40", "gene_names_refseq": "D8Bwg1265e; Rnasep1; Rpp40", "protein_names_uniprotkb": "Ribonuclease P protein subunit p40; RNaseP protein p40", "protein_names_refseq": "RNaseP protein p40; ribonuclease P 40kDa subunit; ribonuclease P protein subunit p40 isoform 1; ribonuclease P protein subunit p40; ribonuclease P1", "tax_id": 10090, "disease": "", "pathway": " (mmu:208366); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;25428506;31219806;34428180", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX66", "ec_number_list": [], "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0000172 ribonuclease MRP complex;GO:0030677 ribonuclease P complex", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R1F9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X9R7-1", "uniprot_id": [ { "id": "RN148_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X9R7", "type": "external" } ], "mass": 35463.0, "length": 316, "protein_name": "RING finger protein 148", "gene_name": "Rnf148", "organism": "Mouse", "refseq_name": "RING finger protein 148 precursor", "refseq_ac": [ { "id": "NP_082030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082030", "type": "external" } ], "gene_names_uniprotkb": "Rnf148; Greul3", "gene_names_refseq": "4933432M07Rik; Greul3; Rnf148", "protein_names_uniprotkb": "RING finger protein 148; Goliath-related E3 ubiquitin-protein ligase 3", "protein_names_refseq": "RING finger protein 148 precursor; goliath-related E3 ubiquitin-protein ligase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71300)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12435366;35831855", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CGR1;Q9D3V4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3X9R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQH8-1", "uniprot_id": [ { "id": "RPP14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQH8", "type": "external" } ], "mass": 13565.0, "length": 122, "protein_name": "Ribonuclease P protein subunit p14", "gene_name": "Rpp14", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p14", "refseq_ac": [ { "id": "NP_080214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080214", "type": "external" } ], "gene_names_uniprotkb": "Rpp14; Htd2", "gene_names_refseq": "2610511E03Rik; Rpp14", "protein_names_uniprotkb": "Ribonuclease P protein subunit p14", "protein_names_refseq": "ribonuclease P 14kDa subunit; ribonuclease P protein subunit p14", "tax_id": 10090, "disease": "", "pathway": " (mmu:109729085); (mmu:67053); (R-MMU-6791226)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005730 nucleolus;GO:0000172 ribonuclease MRP complex;GO:0005739 mitochondrion", "go_biological_process": "GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZR0-1", "uniprot_id": [ { "id": "RNF25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZR0", "type": "external" } ], "mass": 51227.0, "length": 456, "protein_name": "E3 ubiquitin-protein ligase RNF25", "gene_name": "Rnf25", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF25 isoform 2", "refseq_ac": [ { "id": "NP_001292159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292159", "type": "external" } ], "gene_names_uniprotkb": "Rnf25", "gene_names_refseq": "0610009H16Rik; AO7; Rnf25", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF25; 2.3.2.27; RING finger protein 25; RING finger protein AO7", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF25 isoform 2; E3 ubiquitin-protein ligase RNF25; RING finger protein AO7; RING-type E3 ubiquitin transferase RNF25", "tax_id": 10090, "disease": "", "pathway": " (mmu:57751); (R-MMU-983168)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10500182;12748188;18757723;21750661;25428506;31219806;34428180", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (By similarity). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (By similarity). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (PubMed:10500182, PubMed:18757723). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells, [RefSeq, PubMed]; RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAL8;Q9DCW7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051059 NF-kappaB binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006415 translational termination;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QZR0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35292-1", "uniprot_id": [ { "id": "RNS2B_MOUSE", "url": "https://www.uniprot.org/uniprot/O35292", "type": "external" } ], "mass": 17514.0, "length": 155, "protein_name": "Ribonuclease 2B", "gene_name": "Rnase2b", "organism": "Mouse", "refseq_name": "ribonuclease 2B precursor", "refseq_ac": [ { "id": "NP_062271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062271", "type": "external" } ], "gene_names_uniprotkb": "Rnase2b; Ear5", "gene_names_refseq": "Ear5; Raf4; Rnase2b; mR5", "protein_names_uniprotkb": "Ribonuclease 2B; 4.6.1.18; Eosinophil cationic-type ribonuclease 5; MR-5", "protein_names_refseq": "MR-5; eosinophil cationic-type ribonuclease 5; eosinophil-associated ribonuclease 5; eosinophil-associated, ribonuclease A family, member 5; murine ribonuclease 5; ribonuclease 2B precursor; ribonuclease 2B; ribonuclease A f4", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156)", "pathway": " (mmu:54159); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18694936;24005575;27765572;9336452", "class_list": "", "function": "Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11., [RefSeq, PubMed]; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities., [UniProtKB, UniProtKB]; Two novel lncRNAs, FMR5 and FMR6, are differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K416", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0001530 lipopolysaccharide binding;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35292-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35445-1", "uniprot_id": [ { "id": "RNF5_MOUSE", "url": "https://www.uniprot.org/uniprot/O35445", "type": "external" } ], "mass": 19837.0, "length": 180, "protein_name": "E3 ubiquitin-protein ligase RNF5", "gene_name": "Rnf5", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF5", "refseq_ac": [ { "id": "NP_062276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062276", "type": "external" } ], "gene_names_uniprotkb": "Rnf5; Ng2", "gene_names_refseq": "2410131O05Rik; NG2; Rnf5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF5; 2.3.2.27; RING finger protein 5", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF5; RING-type E3 ubiquitin transferase RNF5", "tax_id": 10090, "disease": "", "pathway": " (mmu:54197); (R-MMU-382556); (R-MMU-9931269)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12861019;14656967;16166642;18216283;18270596;23093945;34735734;35584187;36270989", "class_list": "", "function": "E3 ubiquitin ligase RNF5 attenuates pathological cardiac hypertrophy through STING. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination., [RefSeq, PubMed]; Importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:23093945). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (By similarity). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (By similarity). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (By similarity). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (By similarity). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945)., [UniProtKB, UniProtKB, PubMed]; Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity. Publication Status: Online-Only, [RefSeq, PubMed]; RNF5 regulates cell motility by targeting paxillin ubiquitination and altered localization, [RefSeq, PubMed]; Revealed by small interfering RNA methods that the ubiquitin ligase RMA1 functioned as an E3 enzyme upstream of gp78, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009617 response to bacterium;GO:0010507 negative regulation of autophagy;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35445-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54965-1", "uniprot_id": [ { "id": "RNF13_MOUSE", "url": "https://www.uniprot.org/uniprot/O54965", "type": "external" } ], "mass": 42732.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase RNF13", "gene_name": "Rnf13", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF13 isoform a precursor", "refseq_ac": [ { "id": "NP_001106884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106884", "type": "external" } ], "gene_names_uniprotkb": "Rnf13; Rzf", "gene_names_refseq": "2010001H16Rik; Rnf13; Rzf", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF13; 2.3.2.27; RING finger protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF13 isoform a precursor; E3 ubiquitin-protein ligase RNF13; RING-type E3 ubiquitin transferase RNF13", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 73 (Disease Ontology:DOID:0112209)", "pathway": " (mmu:24017)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;18250455;19292867;20230530;21750661;22890573;26192747;26495903;26740625;28011936;34428180;35984892;37852547;37857628;39031743", "class_list": "", "function": "E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:19292867). Involved in apoptosis regulation (By similarity). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). Also involved in protein trafficking and localization (By similarity)., [UniProtKB, PubMed, UniProtKB]; RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; RNF13 is involved in the regulation of the SNARE complex, which thereby controls synaptic function., [RefSeq, PubMed]; RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway., [RefSeq, PubMed]; This gene encodes a member of the PA-TM-RING family of proteins that contain a protease associated (PA) domain and a RING finger domain separated by a transmembrane (TM) domain. The encoded protein is an E3 ubiquitin ligase localized to the endosomal-lysosomal vesicles and inner nuclear membrane. Mice lacking the encoded protein have impaired learning abilities associated with a decreased synaptic vesicle density and dysregulated SNARE complex assembly. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on the X chromosome. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54966;Q6PEA8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "O54965-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88796-1", "uniprot_id": [ { "id": "RPP30_MOUSE", "url": "https://www.uniprot.org/uniprot/O88796", "type": "external" } ], "mass": 29473.0, "length": 268, "protein_name": "Ribonuclease P protein subunit p30", "gene_name": "Rpp30", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p30", "refseq_ac": [ { "id": "NP_062301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062301", "type": "external" } ], "gene_names_uniprotkb": "Rpp30; Rnasep2", "gene_names_refseq": "Rnasep2; Rpp30; TSG15", "protein_names_uniprotkb": "Ribonuclease P protein subunit p30; RNase P subunit 2; RNaseP protein p30", "protein_names_refseq": "RNase P subunit 2; RNaseP protein p30; ribonuclease P protein subunit p30; ribonuclease P/MRP 30kDa subunit; ribonuclease P2", "tax_id": 10090, "disease": "", "pathway": " (mmu:54364); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22645316;28135057;31219806;9630247", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88796-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00683-1", "uniprot_id": [ { "id": "RNAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/P00683", "type": "external" } ], "mass": 16820.0, "length": 149, "protein_name": "Ribonuclease pancreatic", "gene_name": "Rnase1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnase1; Rib-1; Rib1; Rns1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonuclease pancreatic; 4.6.1.18; RNase 1; RNase A", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1840677;2299980;556267", "class_list": "", "function": "Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004540 RNA nuclease activity;GO:0004522 ribonuclease A activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00683-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32958-1", "uniprot_id": [ { "id": "ROM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P32958", "type": "external" } ], "mass": 37265.0, "length": 351, "protein_name": "Rod outer segment membrane protein 1", "gene_name": "Rom1", "organism": "Mouse", "refseq_name": "rod outer segment membrane protein 1", "refseq_ac": [ { "id": "NP_033099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033099", "type": "external" } ], "gene_names_uniprotkb": "Rom1; Rom-1", "gene_names_refseq": "M101156; Rgsc1156; Rom-1; Rom1; Rosp1; Tspan23", "protein_names_uniprotkb": "Rod outer segment membrane protein 1; ROSP1", "protein_names_refseq": "rod outer segment membrane protein 1", "tax_id": 10090, "disease": "retinitis pigmentosa 7 (Disease Ontology:DOID:0110383)", "pathway": " (mmu:19881)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10802659;25428506;26406599;29961824;32716032;37991486;8504299", "class_list": "", "function": "Plays a role in rod outer segment (ROS) morphogenesis (PubMed:10802659). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (PubMed:10802659). Involved in the maintenance of the retina outer nuclear layer (PubMed:10802659)., [UniProtKB, PubMed, UniProtKB]; ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease., [RefSeq, PubMed]; ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32958-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47968-1", "uniprot_id": [ { "id": "RPIA_MOUSE", "url": "https://www.uniprot.org/uniprot/P47968", "type": "external" } ], "mass": 32451.0, "length": 303, "protein_name": "Ribose-5-phosphate isomerase", "gene_name": "Rpia", "organism": "Mouse", "refseq_name": "ribose-5-phosphate isomerase", "refseq_ac": [ { "id": "NP_033101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033101", "type": "external" } ], "gene_names_uniprotkb": "Rpia; Rpi", "gene_names_refseq": "RPI; Rpia", "protein_names_uniprotkb": "Ribose-5-phosphate isomerase; 5.3.1.6; Phosphoriboisomerase", "protein_names_refseq": "phosphoriboisomerase; ribose-5-phosphate isomerase", "tax_id": 10090, "disease": "", "pathway": " (mmu:19895); (R-MMU-71336); (R-MMU-73843)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "25429733;7758956", "class_list": "", "function": "Study provides new insight into the molecular mechanisms by which RPIA overexpression can induce oncogenesis in hepatocellular carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVI8", "ec_number_list": [ { "id": "5.3.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.6", "type": "external" } ], "go_molecular_function": "GO:0004751 ribose-5-phosphate isomerase activity;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0048029 monosaccharide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006014 D-ribose metabolic process;GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47968-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50636-1", "uniprot_id": [ { "id": "RN19A_MOUSE", "url": "https://www.uniprot.org/uniprot/P50636", "type": "external" } ], "mass": 90632.0, "length": 840, "protein_name": "E3 ubiquitin-protein ligase RNF19A", "gene_name": "Rnf19a", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF19A isoform 1", "refseq_ac": [ { "id": "NP_038951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038951", "type": "external" } ], "gene_names_uniprotkb": "Rnf19a; Geg-154; Rnf19; Xybp", "gene_names_refseq": "Dorfin; Rnf19a; Rnf19; UIP117; Ubce7ip2; XYbp", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF19A; 2.3.2.31; Dorfin; Double ring-finger protein; Gametogenesis-expressed protein GEG-154; RING finger protein 19A; UBCM4-interacting protein 117; UIP117; XY body protein; XYbp", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF19A isoform 1; E3 ubiquitin-protein ligase RNF19A; UBCM4-interacting protein 117; XY body protein; double ring-finger protein; gametogenesis-expressed protein GEG-154; ring finger protein (C3HC4 type) 19; ubiquitin conjugating enzyme 7 interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:30945); (R-MMU-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10431818;10585566;15456787;17666395;19610091;21750661;26495903;26553645;34990937;37480121;7616504", "class_list": "", "function": "Dorfin ubiquitylated mutant SOD1 by recognizing the Cys(6)- and Cys(111)-disulfide cross-linked form and targeted it for proteasomal degradation, [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR., [UniProtKB, PubMed]; H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection. Publication Status: Online-Only, [RefSeq, PubMed]; In addition to causing a decrease in the amount of mutant SOD1 protein in the spinal cord, Dorfin overexpression ameliorated neurological phenotypes and motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis., [RefSeq, PubMed]; RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1., [RefSeq, PubMed]; These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGT2;Q9QUJ5", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P50636-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58283-1", "uniprot_id": [ { "id": "RN216_MOUSE", "url": "https://www.uniprot.org/uniprot/P58283", "type": "external" } ], "mass": 97682.0, "length": 853, "protein_name": "E3 ubiquitin-protein ligase RNF216", "gene_name": "Rnf216", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF216 isoform A", "refseq_ac": [ { "id": "NP_542128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542128", "type": "external" } ], "gene_names_uniprotkb": "Rnf216; Triad3; Ubce7ip1; Uip83; Zin", "gene_names_refseq": "2810055G22Rik; F830018F18Rik; Rnf216; TRIAD3; UIP83; Ubce7ip1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF216; 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1", "protein_names_refseq": "E3 ubiquitin ligase; E3 ubiquitin-protein ligase RNF216 isoform A; E3 ubiquitin-protein ligase RNF216; RING-type E3 ubiquitin transferase RNF216; triad domain-containing protein 3; ubcM4-interacting protein 83; ubiquitin-conjugating enzyme 7-interacting protein 1", "tax_id": 10090, "disease": "Gordon Holmes syndrome (Disease Ontology:DOID:0111587)", "pathway": " (mmu:108086)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10431818;19892989;21183079;21750661;25428506;25428507;25484083;25605945;27802388;30084848;30649198;30779550;33724554;34428180;37439148;37625569", "class_list": "", "function": "E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination. Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9. In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition. Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (By similarity). Plays aso an essential role in spermatogenesis and male fertility (PubMed:30649198). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (PubMed:33724554). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (PubMed:37439148)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases, [RefSeq, PubMed]; RNF216 affects the stability of STAU2 in the hypothalamus., [RefSeq, PubMed]; Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U493;Q3UE56;Q3UGM3;Q68FN0;Q6P1H8;Q6PWY5;Q8BN27;Q8C1U3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0032648 regulation of interferon-beta production;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P58283-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60154-1", "uniprot_id": [ { "id": "RNAS9_MOUSE", "url": "https://www.uniprot.org/uniprot/P60154", "type": "external" } ], "mass": 21378.0, "length": 184, "protein_name": "Inactive ribonuclease-like protein 9", "gene_name": "Rnase9", "organism": "Mouse", "refseq_name": "inactive ribonuclease-like protein 9 precursor", "refseq_ac": [ { "id": "NP_898853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898853", "type": "external" } ], "gene_names_uniprotkb": "Rnase9", "gene_names_refseq": "ESRL; Rak1; Rnase9", "protein_names_uniprotkb": "Inactive ribonuclease-like protein 9", "protein_names_refseq": "epididymal RNase; inactive ribonuclease-like protein 9 precursor; inactive ribonuclease-like protein 9; ribonuclease A family, member 9; ribonuclease A k1; ribonuclease-like protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:328401)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12920233;24719258", "class_list": "", "function": "Does not exhibit any ribonuclease activity., [UniProtKB]; RNASE9 is dispensable for fertility, but the absence of RNASE9 during epididymal transit results in impaired sperm maturation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0060474 positive regulation of flagellated sperm motility involved in capacitation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60154-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60603-1", "uniprot_id": [ { "id": "ROMO1_MOUSE", "url": "https://www.uniprot.org/uniprot/P60603", "type": "external" } ], "mass": 8183.0, "length": 79, "protein_name": "Reactive oxygen species modulator 1", "gene_name": "Romo1", "organism": "Mouse", "refseq_name": "reactive oxygen species modulator 1", "refseq_ac": [ { "id": "NP_001157688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157688", "type": "external" } ], "gene_names_uniprotkb": "Romo1", "gene_names_refseq": "2010100O12Rik; Romo1", "protein_names_uniprotkb": "Reactive oxygen species modulator 1; Protein MGR2 homolog; ROS modulator 1", "protein_names_refseq": "ROS modulator 1; protein MGR2 homolog; reactive oxygen species modulator 1", "tax_id": 10090, "disease": "ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (mmu:67067)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16842742", "class_list": "", "function": "Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity)., [UniProtKB]; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BHV9;Q9CQ98;Q9H1N2", "ec_number_list": [], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60603-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62876-1", "uniprot_id": [ { "id": "RPAB5_MOUSE", "url": "https://www.uniprot.org/uniprot/P62876", "type": "external" } ], "mass": 7645.0, "length": 67, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "gene_name": "Polr2l", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC5", "refseq_ac": [ { "id": "NP_079869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079869", "type": "external" } ], "gene_names_uniprotkb": "Polr2l", "gene_names_refseq": "2510029B14Rik; Polr2l", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5; RPB10 homolog", "protein_names_refseq": "DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; RNA polymerases I, II, and III subunit ABC5; RPB10 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66491); (R-MMU-112382); (R-MMU-113418); (R-MMU-5250924); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 29, "publication_count": 1, "publication_id_list": "25605945", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52436;Q3UF14", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TDK6-1", "uniprot_id": [ { "id": "ROGDI_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TDK6", "type": "external" } ], "mass": 32100.0, "length": 287, "protein_name": "Protein rogdi homolog", "gene_name": "Rogdi", "organism": "Mouse", "refseq_name": "protein rogdi homolog", "refseq_ac": [ { "id": "NP_573448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573448", "type": "external" } ], "gene_names_uniprotkb": "Rogdi; Lzf", "gene_names_refseq": "0610011C19Rik; Lzf; Rogdi", "protein_names_uniprotkb": "Protein rogdi homolog; Leucine-zipper-containing LZF", "protein_names_refseq": "leucine zipper domain protein; leucine-zipper-containing LZF; protein rogdi homolog", "tax_id": 10090, "disease": "Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668)", "pathway": " (mmu:66049)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11740862;21750661;31219806;38172607", "class_list": "", "function": "The Rogdi knockout mouse is a model for Kohlschutter-Tonz syndrome. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BL37;Q922N4;Q923H8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043291 RAVE complex;GO:0005635 nuclear envelope;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008284 positive regulation of cell population proliferation;GO:0050905 neuromuscular process;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3TDK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TEL6-1", "uniprot_id": [ { "id": "RN157_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TEL6", "type": "external" } ], "mass": 74534.0, "length": 685, "protein_name": "E3 ubiquitin ligase Rnf157", "gene_name": "Rnf157", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf157; Kiaa1917", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin ligase Rnf157; 2.3.2.27; RING finger protein 157; RING-type E3 ubiquitin transferase Rnf157", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;25342469;34428180", "class_list": "", "function": "E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity)., [UniProtKB, UniProtKB, PubMed]; E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80T75", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0044297 cell body", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0043066 negative regulation of apoptotic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TEL6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U9F6-1", "uniprot_id": [ { "id": "RN166_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U9F6", "type": "external" } ], "mass": 26064.0, "length": 237, "protein_name": "E3 ubiquitin-protein ligase RNF166", "gene_name": "Rnf166", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF166 isoform 1", "refseq_ac": [ { "id": "NP_001028314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028314", "type": "external" } ], "gene_names_uniprotkb": "Rnf166", "gene_names_refseq": "1110031E24Rik; Rnf166; Zfp313l", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF166; 2.3.2.27; RING finger protein 166; RING-type E3 ubiquitin transferase RNF166", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF166 isoform 1; E3 ubiquitin-protein ligase RNF166; RING-type E3 ubiquitin transferase RNF166; zinc finger protein 228; zinc finger protein 313", "tax_id": 10090, "disease": "", "pathway": " (mmu:68718)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Also plays a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0006914 autophagy;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3U9F6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHJ8-1", "uniprot_id": [ { "id": "RNF44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHJ8", "type": "external" } ], "mass": 45497.0, "length": 407, "protein_name": "RING finger protein 44", "gene_name": "Rnf44", "organism": "Mouse", "refseq_name": "RING finger protein 44 isoform 1", "refseq_ac": [ { "id": "NP_001139497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139497", "type": "external" } ], "gene_names_uniprotkb": "Rnf44; Kiaa1100", "gene_names_refseq": "Rnf44; mKIAA1100", "protein_names_uniprotkb": "RING finger protein 44", "protein_names_refseq": "RING finger protein 44 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105239)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;31219806", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAC8;Q3TVH9;Q6ZPX8;Q8VD22", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UHJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPE3-1", "uniprot_id": [ { "id": "RMI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPE3", "type": "external" } ], "mass": 15838.0, "length": 149, "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "Rmi2", "organism": "Mouse", "refseq_name": "recQ-mediated genome instability protein 2", "refseq_ac": [ { "id": "NP_001156404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156404", "type": "external" } ], "gene_names_uniprotkb": "Rmi2; Gm929", "gene_names_refseq": "A630055G03Rik; Gm537; Gm929; Rmi2", "protein_names_uniprotkb": "RecQ-mediated genome instability protein 2", "protein_names_refseq": "RMI2, RecQ mediated genome instability 2, homolog; recQ-mediated genome instability protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:223970); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2Y5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0033045 regulation of sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UPE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTZ6-1", "uniprot_id": [ { "id": "RN150_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTZ6", "type": "external" } ], "mass": 48013.0, "length": 437, "protein_name": "RING finger protein 150", "gene_name": "Rnf150", "organism": "Mouse", "refseq_name": "RING finger protein 150 precursor", "refseq_ac": [ { "id": "NP_796352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796352", "type": "external" } ], "gene_names_uniprotkb": "Rnf150; Kiaa1214", "gene_names_refseq": "A630007N06Rik; C030044C12Rik; Greul5; Rnf150; mKIAA1214", "protein_names_uniprotkb": "RING finger protein 150", "protein_names_refseq": "RING finger protein 150 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:330812)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5DTZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GAM7-1", "uniprot_id": [ { "id": "RNS13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GAM7", "type": "external" } ], "mass": 17592.0, "length": 153, "protein_name": "Probable inactive ribonuclease-like protein 13", "gene_name": "Rnase13", "organism": "Mouse", "refseq_name": "probable inactive ribonuclease-like protein 13 precursor", "refseq_ac": [ { "id": "NP_001011687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011687", "type": "external" } ], "gene_names_uniprotkb": "Rnase13", "gene_names_refseq": "Rnase13", "protein_names_uniprotkb": "Probable inactive ribonuclease-like protein 13", "protein_names_refseq": "pancreatic ribonuclease; probable inactive ribonuclease-like protein 13 precursor; probable inactive ribonuclease-like protein 13; ribonuclease-like protein 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:497071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15676279", "class_list": "", "function": "Does not exhibit any ribonuclease activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GAM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GAM8-1", "uniprot_id": [ { "id": "RNS12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GAM8", "type": "external" } ], "mass": 16936.0, "length": 145, "protein_name": "Probable inactive ribonuclease-like protein 12", "gene_name": "Rnase12", "organism": "Mouse", "refseq_name": "probable inactive ribonuclease-like protein 12 precursor", "refseq_ac": [ { "id": "NP_001011875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011875", "type": "external" } ], "gene_names_uniprotkb": "Rnase12", "gene_names_refseq": "Rai1; Rnase12", "protein_names_uniprotkb": "Probable inactive ribonuclease-like protein 12", "protein_names_refseq": "probable inactive ribonuclease-like protein 12 precursor; probable inactive ribonuclease-like protein 12; ribonuclease A i1; ribonuclease-like protein 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:497106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15676279", "class_list": "", "function": "Does not exhibit any ribonuclease activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GAM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GAM9-1", "uniprot_id": [ { "id": "RNS11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5GAM9", "type": "external" } ], "mass": 20883.0, "length": 192, "protein_name": "Putative inactive ribonuclease 11", "gene_name": "Rnase11", "organism": "Mouse", "refseq_name": "putative inactive ribonuclease 11 precursor", "refseq_ac": [ { "id": "NP_001011877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011877", "type": "external" } ], "gene_names_uniprotkb": "Rnase11", "gene_names_refseq": "Raj1; Rnase11", "protein_names_uniprotkb": "Putative inactive ribonuclease 11; RNase 11", "protein_names_refseq": "putative inactive ribonuclease 11 precursor; putative inactive ribonuclease 11; ribonuclease A j1", "tax_id": 10090, "disease": "", "pathway": " (mmu:497113)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15676279", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ01", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5GAM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCP0-1", "uniprot_id": [ { "id": "RNF43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCP0", "type": "external" } ], "mass": 86304.0, "length": 784, "protein_name": "E3 ubiquitin-protein ligase RNF43", "gene_name": "Rnf43", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF43 isoform 1 precursor", "refseq_ac": [ { "id": "NP_766036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766036", "type": "external" } ], "gene_names_uniprotkb": "Rnf43", "gene_names_refseq": "4732452J19Rik; Rnf43", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF43; 2.3.2.27; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF43 isoform 1 precursor; E3 ubiquitin-protein ligase RNF43; RING-type E3 ubiquitin transferase RNF43", "tax_id": 10090, "disease": "villous adenoma (Disease Ontology:DOID:0050869); stomach cancer (Disease Ontology:DOID:10534); endometrial cancer (Disease Ontology:DOID:1380); ascending colon cancer (Disease Ontology:DOID:218); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); cholangiocarcinoma (Disease Ontology:DOID:4947); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (mmu:207742); (R-MMU-4641263)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;22895187;29769720;32934222;36468684;38622664", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)., [UniProtKB, PubMed, UniProtKB]; RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation, [RefSeq, PubMed]; RNF43 induces the turnover of protease-activated receptor 2 in colon cancer., [RefSeq, PubMed]; Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2KGH3;Q6DI76;Q8BME0;Q8C191;Q8K0X4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0005109 frizzled binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0030178 negative regulation of Wnt signaling pathway;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0072089 stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5NCP0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SPX3-1", "uniprot_id": [ { "id": "RN215_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SPX3", "type": "external" } ], "mass": 41610.0, "length": 379, "protein_name": "RING finger protein 215", "gene_name": "Rnf215", "organism": "Mouse", "refseq_name": "RING finger protein 215 isoform 1 precursor", "refseq_ac": [ { "id": "NP_082135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082135", "type": "external" } ], "gene_names_uniprotkb": "Rnf215", "gene_names_refseq": "0610009J22Rik; Rnf215", "protein_names_uniprotkb": "RING finger protein 215", "protein_names_refseq": "RING finger protein 215 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5SPX2;Q5SPX4;Q9DCW1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SPX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SWK7-1", "uniprot_id": [ { "id": "RN145_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SWK7", "type": "external" } ], "mass": 74648.0, "length": 663, "protein_name": "RING finger protein 145", "gene_name": "Rnf145", "organism": "Mouse", "refseq_name": "RING finger protein 145 isoform 1", "refseq_ac": [ { "id": "NP_083138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083138", "type": "external" } ], "gene_names_uniprotkb": "Rnf145", "gene_names_refseq": "3732413I11Rik; Rnf145; TMRF1", "protein_names_uniprotkb": "RING finger protein 145; 2.3.2.27", "protein_names_refseq": "RING finger protein 145 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74315)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26194095;28231341;29068315;29374057;30543180;31219806", "class_list": "", "function": "E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species (PubMed:26194095). Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function (PubMed:29374057). In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately down-regulating cholesterol biosynthesis (PubMed:29068315)., [UniProtKB, PubMed, PubMed, PubMed]; Implicated in proteostasis of Nox2 complex Publication Status: Online-Only, [RefSeq, PubMed]; Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. Publication Status: Online-Only, [RefSeq, PubMed]; N the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation Publication Status: Online-Only, [RefSeq, PubMed]; We report the identification of RNF145 as an ER-resident E3 ubiquitin ligase that is transcriptionally controlled by LXR. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BXX5;Q9CXG1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5SWK7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62190-1", "uniprot_id": [ { "id": "RON_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62190", "type": "external" } ], "mass": 150519.0, "length": 1378, "protein_name": "Macrophage-stimulating protein receptor", "gene_name": "Mst1r", "organism": "Mouse", "refseq_name": "macrophage-stimulating protein receptor isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_033100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033100", "type": "external" } ], "gene_names_uniprotkb": "Mst1r; Ron; Stk", "gene_names_refseq": "CD136; CDw136; Fv-2; Fv2; Mst1r; PTK8; Ron; STK; p185-Ron", "protein_names_uniprotkb": "Macrophage-stimulating protein receptor; 2.7.10.1; MSP receptor; Stem cell-derived tyrosine kinase; p185-Ron", "protein_names_refseq": "MSP receptor; friend virus susceptibility 2; macrophage-stimulating protein receptor isoform 1 preproprotein; macrophage-stimulating protein receptor; receptor protein tyrosine kinase, c-met-related; stem cell-derived tyrosine kinase", "tax_id": 10090, "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (mmu:19882); (R-MMU-8852405)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;10508511;11483734;17008558;21750661;25428506;33673346;34203471;34428180;34712728;36210013;37029299;37828378;8193352;8545120;9467940;9680329", "class_list": "", "function": "Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; RON Mediates Tumor-Promoting Effects in Endometrial Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RON-augmented cholesterol biosynthesis in breast cancer metastatic progression and recurrence., [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand., [UniProtKB, UniProtKB]; Ron impacts the progression of inflammatory immune responses in vivo and further support a role for the Ron receptor and its various forms in liver pathophysiology., [RefSeq, PubMed]; This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "E9QMZ4;Q62555", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0001725 stress fiber;GO:0005773 vacuole", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0045087 innate immune response;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q62190-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63871-1", "uniprot_id": [ { "id": "RPAB4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63871", "type": "external" } ], "mass": 6974.0, "length": 58, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC4", "gene_name": "Polr2k", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b", "refseq_ac": [ { "id": "NP_075616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075616", "type": "external" } ], "gene_names_uniprotkb": "Polr2k; Mt1a", "gene_names_refseq": "ABC10-alpha; MafY; Mt1a; Polr2k; RPABC4; RPB10alpha; RPB12; RPB7.0", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC4; DNA-directed RNA polymerase II subunit K; Metallothionein-I gene transcription activator; RNA polymerases I, II, and III subunit ABC4; RPB10alpha", "protein_names_refseq": "DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b; DNA-directed RNA polymerases I, II, and III subunit RPABC4; metallothionein-I gene transcription activator", "tax_id": 10090, "disease": "", "pathway": " (mmu:17749); (R-MMU-112382); (R-MMU-113418); (R-MMU-5250924); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 29, "publication_count": 2, "publication_id_list": "12673834;8329119", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively., [UniProtKB, UniProtKB, UniProtKB]; Metallothionein-I was upregulated by a cryolesion to a higher extent in GFAP-IL-6 transgenic mice, suggesting that it could be related to the neuroprotection afforded by the transgenic expression of IL-6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I;GO:0006383 transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EF8-1", "uniprot_id": [ { "id": "RPGFL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68EF8", "type": "external" } ], "mass": 73695.0, "length": 662, "protein_name": "Rap guanine nucleotide exchange factor-like 1", "gene_name": "Rapgefl1", "organism": "Mouse", "refseq_name": "rap guanine nucleotide exchange factor-like 1", "refseq_ac": [ { "id": "NP_001074394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074394", "type": "external" } ], "gene_names_uniprotkb": "Rapgefl1", "gene_names_refseq": "B230105J10; Rapgefl1", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor-like 1", "protein_names_refseq": "rap guanine nucleotide exchange factor-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:268480)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable guanine nucleotide exchange factor (GEF)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L3T1", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68EF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q768S4-1", "uniprot_id": [ { "id": "RPH3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q768S4", "type": "external" } ], "mass": 33259.0, "length": 302, "protein_name": "Rab effector Noc2", "gene_name": "Rph3al", "organism": "Mouse", "refseq_name": "rab effector Noc2 isoform 2", "refseq_ac": [ { "id": "NP_001278088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278088", "type": "external" } ], "gene_names_uniprotkb": "Rph3al; Gm1753; Noc2", "gene_names_refseq": "Gm1753; Noc2; Rph3al", "protein_names_uniprotkb": "Rab effector Noc2; No C2 domains protein; Rabphilin-3A-like protein", "protein_names_refseq": "no C2 domains protein; rab effector Noc2 isoform 2; rab effector Noc2; rabphilin-3A-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:380714)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12578829;14722103;15159548;16835753;21183079;21750661;22615885;27927751", "class_list": "", "function": "In pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca(2+)](i) increases., [RefSeq, PubMed]; Investigated localization of Noc2 immunohistochemically in various endocrine and exocrine tissues in normal mice, including pancreatic islets, the adrenal gland, pituitary gland, salivary gland, and thyroid gland, [RefSeq, PubMed]; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells., [UniProtKB, PubMed, PubMed]; Results show that Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells., [RefSeq, PubMed]; These results suggest that the dual effector, Noc2, regulates the transition from Rab2a-mediated granule biogenesis to Rab27a-mediated granule exocytosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D353", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0030274 LIM domain binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0030141 secretory granule;GO:0045202 synapse;GO:0030658 transport vesicle membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032024 positive regulation of insulin secretion;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0050714 positive regulation of protein secretion;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q768S4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78WZ7-1", "uniprot_id": [ { "id": "RPA43_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78WZ7", "type": "external" } ], "mass": 36721.0, "length": 330, "protein_name": "DNA-directed RNA polymerase I subunit RPA43", "gene_name": "Polr1f", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase I subunit RPA43", "refseq_ac": [ { "id": "NP_758457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758457", "type": "external" } ], "gene_names_uniprotkb": "Polr1f; Twistnb", "gene_names_refseq": "2410173G11; 2810024J17Rik; D16Wsu83e; Polr1f; Twistnb", "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA43; DNA-directed RNA polymerase I subunit F; Twist neighbor protein", "protein_names_refseq": "DNA-directed RNA polymerase I subunit F; DNA-directed RNA polymerase I subunit RPA43; twist basic helix-loop-helix transcription factor 1 neighbor; twist neighbor protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:28071); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12393749;12438708;34428180", "class_list": "", "function": "Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6L1;Q8CEP7;Q9CS60", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0005736 RNA polymerase I complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006362 transcription elongation by RNA polymerase I;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q78WZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UW8-1", "uniprot_id": [ { "id": "RPAB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UW8", "type": "external" } ], "mass": 24570.0, "length": 210, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "gene_name": "Polr2e", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "refseq_ac": [ { "id": "NP_079830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079830", "type": "external" } ], "gene_names_uniprotkb": "Polr2e", "gene_names_refseq": "2410021N14Rik; 25kDa; Polr2e; RPB5; XAP4", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-directed RNA polymerase II subunit E; RNA polymerases I, II, and III subunit ABC1; RPB5 homolog", "protein_names_refseq": "DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I, II, and III subunit RPABC1; RNA polymerases I, II, and III subunit ABC1; RPB5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66420); (R-MMU-112382); (R-MMU-113418); (R-MMU-5250924); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73762); (R-MMU-73772); (R-MMU-73776); (R-MMU-73779); (R-MMU-73863); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 29, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80UW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG47-1", "uniprot_id": [ { "id": "RN152_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG47", "type": "external" } ], "mass": 22353.0, "length": 203, "protein_name": "E3 ubiquitin-protein ligase RNF152", "gene_name": "Rnf152", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF152", "refseq_ac": [ { "id": "NP_001153840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153840", "type": "external" } ], "gene_names_uniprotkb": "Rnf152", "gene_names_refseq": "A930029B02Rik; Rnf152", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF152; 2.3.2.27; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF152; RING-type E3 ubiquitin transferase RNF152", "tax_id": 10090, "disease": "", "pathway": " (mmu:320311); (R-MMU-8866654)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "25936802;29300766;31930677", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (By similarity). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (By similarity). Induces apoptosis when overexpressed (By similarity)., [UniProtKB, UniProtKB, PubMed]; RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VF67", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006915 apoptotic process;GO:0010508 positive regulation of autophagy;GO:0031669 cellular response to nutrient levels;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BG47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGI1-1", "uniprot_id": [ { "id": "RNF24_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGI1", "type": "external" } ], "mass": 17254.0, "length": 148, "protein_name": "RING finger protein 24", "gene_name": "Rnf24", "organism": "Mouse", "refseq_name": "RING finger protein 24", "refseq_ac": [ { "id": "NP_848722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848722", "type": "external" } ], "gene_names_uniprotkb": "Rnf24", "gene_names_refseq": "2810473M14Rik; 4930505A13Rik; D2Ertd504e; Rnf24", "protein_names_uniprotkb": "RING finger protein 24", "protein_names_refseq": "RING finger protein 24", "tax_id": 10090, "disease": "", "pathway": " (mmu:51902)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May play a role in TRPCs intracellular trafficking., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BI21-1", "uniprot_id": [ { "id": "RNF38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BI21", "type": "external" } ], "mass": 52168.0, "length": 464, "protein_name": "E3 ubiquitin-protein ligase RNF38", "gene_name": "Rnf38", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF38 isoform 1", "refseq_ac": [ { "id": "NP_780410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780410", "type": "external" } ], "gene_names_uniprotkb": "Rnf38", "gene_names_refseq": "1700065B19Rik; 2610202O07Rik; Oip1; Rnf38", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF38; 2.3.2.27; RING finger protein 38; RING-type E3 ubiquitin transferase RNF38", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF38 isoform 1; E3 ubiquitin-protein ligase RNF38; RING-type E3 ubiquitin transferase RNF38", "tax_id": 10090, "disease": "", "pathway": " (mmu:73469)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;26495903", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P5B1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BI21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLR7-1", "uniprot_id": [ { "id": "RND1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLR7", "type": "external" } ], "mass": 26034.0, "length": 232, "protein_name": "Rho-related GTP-binding protein Rho6", "gene_name": "Rnd1", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein Rho6", "refseq_ac": [ { "id": "NP_766200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766200", "type": "external" } ], "gene_names_uniprotkb": "Rnd1; Rho6", "gene_names_refseq": "A830014L09Rik; Arhs; Rnd1", "protein_names_uniprotkb": "Rho-related GTP-binding protein Rho6; 3.6.5.2; Rho family GTPase 1; Rnd1", "protein_names_refseq": "rho-related GTP-binding protein Rho6", "tax_id": 10090, "disease": "", "pathway": " (mmu:223881); (R-MMU-416550); (R-MMU-416572); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "35102202", "class_list": "", "function": "Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration. Publication Status: Online-Only, [RefSeq, PubMed]; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TSQ9;Q80ZR7;Q8BYF2", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction;GO:0016322 neuron remodeling;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BLR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU88-1", "uniprot_id": [ { "id": "RM22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU88", "type": "external" } ], "mass": 23805.0, "length": 206, "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "Mrpl22", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein uL22m precursor", "refseq_ac": [ { "id": "NP_778166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778166", "type": "external" } ], "gene_names_uniprotkb": "Mrpl22", "gene_names_refseq": "E030011D16Rik; HSPC158; L22mt; MRP-L22; MRP-L25; Mrpl22; Rpml25", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22m; 39S ribosomal protein L22, mitochondrial; L22mt; MRP-L22", "protein_names_refseq": "39S ribosomal protein L22, mitochondrial; large ribosomal subunit protein uL22m precursor; large ribosomal subunit protein uL22m", "tax_id": 10090, "disease": "", "pathway": " (mmu:216767); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BK04", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BU88-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUH7-1", "uniprot_id": [ { "id": "RNF26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUH7", "type": "external" } ], "mass": 46914.0, "length": 424, "protein_name": "E3 ubiquitin-protein ligase RNF26", "gene_name": "Rnf26", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF26", "refseq_ac": [ { "id": "NP_717095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_717095", "type": "external" } ], "gene_names_uniprotkb": "Rnf26", "gene_names_refseq": "8030450I18Rik; Rnf26", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF26; 2.3.2.27; RING finger protein 26", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF26", "tax_id": 10090, "disease": "", "pathway": " (mmu:213211)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6SS41;Q5PR90;Q8BZY8;Q99KC1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0016567 protein ubiquitination;GO:0070979 protein K11-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:1905719 protein localization to perinuclear region of cytoplasm", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BUH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CEF8-1", "uniprot_id": [ { "id": "RN222_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CEF8", "type": "external" } ], "mass": 23003.0, "length": 211, "protein_name": "RING finger protein 222", "gene_name": "Rnf222", "organism": "Mouse", "refseq_name": "RING finger protein 222", "refseq_ac": [ { "id": "NP_796034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796034", "type": "external" } ], "gene_names_uniprotkb": "Rnf222", "gene_names_refseq": "9930039A11Rik; Rnf222", "protein_names_uniprotkb": "RING finger protein 222", "protein_names_refseq": "RING finger protein 222", "tax_id": 10090, "disease": "", "pathway": " (mmu:320040)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B1ARA2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CEF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFI7-1", "uniprot_id": [ { "id": "RPB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFI7", "type": "external" } ], "mass": 133911.0, "length": 1174, "protein_name": "DNA-directed RNA polymerase II subunit RPB2", "gene_name": "Polr2b", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase II subunit RPB2", "refseq_ac": [ { "id": "NP_722493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722493", "type": "external" } ], "gene_names_uniprotkb": "Polr2b", "gene_names_refseq": "Pol2rb; Polr2b; Rpb140; Rpb2", "protein_names_uniprotkb": "DNA-directed RNA polymerase II subunit RPB2; 2.7.7.48; 2.7.7.6; 3'-5' exoribonuclease; 3.1.13.-; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2; RNA-directed RNA polymerase II subunit RPB2", "protein_names_refseq": "3'-5' exoribonuclease; DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; DNA-directed RNA polymerase II subunit RPB2; RNA polymerase II subunit 2; RNA polymerase II subunit B2; RNA-directed RNA polymerase II subunit RPB2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231329); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6781823); (R-MMU-6782135); (R-MMU-6782210); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 22, "publication_count": 23, "publication_id_list": "15601870;18299400;19892989;20173027;20484733;21952136;25428506;25605945;26495903;28011936;28935714;29187734;30084848;31219806;33300544;33649389;34203471;34428180;35820727;37828378;38490996;39627609;40021952", "class_list": "", "function": "Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (By similarity). Forms Pol II active center together with the largest subunit POLR2A/RPB1. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR2A/RPB1 most likely contributing a Mg(2+)-coordinating DxDGD motif and POLR2B/RPB2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. The reversible pyrophosphorolysis can occur at high pyrophosphate concentrations (By similarity). Can proofread the nascent RNA transcript by means of a 3' -> 5' exonuclease activity. If a ribonucleotide is mis-incorporated, backtracks along the template DNA and cleaves the phosphodiester bond releasing the mis-incorporated 5'-ribonucleotide (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; NF-Y recruits RNAPII and general transcription factors onto various CCAAT box-containing promoters to permit strong transcriptional activation independently of histone modifications, [RefSeq, PubMed]; RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription., [UniProtKB, UniProtKB]; TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.14.11.68", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" } ], "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006354 DNA-templated transcription elongation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q8CFI7-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGM2-1", "uniprot_id": [ { "id": "RP1L1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGM2", "type": "external" } ], "mass": 199686.0, "length": 1859, "protein_name": "Retinitis pigmentosa 1-like 1 protein", "gene_name": "Rp1l1", "organism": "Mouse", "refseq_name": "retinitis pigmentosa 1-like 1 protein", "refseq_ac": [ { "id": "NP_666358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666358", "type": "external" } ], "gene_names_uniprotkb": "Rp1l1; Rp1hl1", "gene_names_refseq": "Dcdc4; Rp1hl1; Rp1l1", "protein_names_uniprotkb": "Retinitis pigmentosa 1-like 1 protein; Retinitis pigmentosa 1-like protein 1", "protein_names_refseq": "retinitis pigmentosa 1-like 1 protein; retinitis pigmentosa 1-like protein 1", "tax_id": 10090, "disease": "occult macular dystrophy (Disease Ontology:DOID:0050578); retinitis pigmentosa 88 (Disease Ontology:DOID:0112145); eye disease (Disease Ontology:DOID:5614)", "pathway": " (mmu:271209)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12634863;12724644;19657028;37828378", "class_list": "", "function": "Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors., [UniProtKB, PubMed]; Rp1 and Rp1L1 play essential and synergistic roles in affecting photosensitivity and morphogenesis of rod photoreceptors. Our findings suggest that mutations in RP1L1 could underlie retinopathy or modify RP1 disease expression, [RefSeq, PubMed]; This gene encodes a member of the doublecortin family. This protein is a retinal-specific protein. It contains two N-terminal doublecortin domains, which can assemble and stabilize axonemal microtubules, but lacks the C-terminal repetitive regions including the 16aa repeat found in human RP1L1. This protein and the RP1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8K0I4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0032391 photoreceptor connecting cilium;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0035845 photoreceptor cell outer segment organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CGM2-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0W3-1", "uniprot_id": [ { "id": "RN208_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0W3", "type": "external" } ], "mass": 28390.0, "length": 265, "protein_name": "RING finger protein 208", "gene_name": "Rnf208", "organism": "Mouse", "refseq_name": "RING finger protein 208", "refseq_ac": [ { "id": "NP_789804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789804", "type": "external" } ], "gene_names_uniprotkb": "Rnf208", "gene_names_refseq": "1110061N23Rik; Rnf208", "protein_names_uniprotkb": "RING finger protein 208", "protein_names_refseq": "RING finger protein 208", "tax_id": 10090, "disease": "", "pathway": " (mmu:68846)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AI04;B2FDG8;Q8BTC4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K0W3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZS5-1", "uniprot_id": [ { "id": "RN183_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZS5", "type": "external" } ], "mass": 21625.0, "length": 190, "protein_name": "E3 ubiquitin-protein ligase RNF183", "gene_name": "Rnf183", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF183", "refseq_ac": [ { "id": "NP_705724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705724", "type": "external" } ], "gene_names_uniprotkb": "Rnf183", "gene_names_refseq": "5830442J12Rik; Rnf183", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF183; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF183; probable E3 ubiquitin-protein ligase RNF183", "tax_id": 10090, "disease": "", "pathway": " (mmu:76072)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "26818663;29300766;29507230;30413537;31053298;31732153", "class_list": "", "function": "Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29300766, PubMed:31732153). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity). Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (PubMed:31732153)., [UniProtKB, UniProtKB, PubMed, PubMed]; RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease., [RefSeq, PubMed]; Results indicated that RNF183 is predominantly expressed in the renal medullary collecting ducts, and that decreased renal medullary tonicity by furosemide treatment decreases RNF183 expression by NFAT5 downregulation, [RefSeq, PubMed]; These results indicate that (i) RNF183 is predominantly expressed in the normal renal medulla, (ii) NFAT5 stimulates transcriptional activation of Rnf183 by binding to its cognate binding motif in the Rnf183 promoter, and (iii) RNF183 protects renal medullary cells from hypertonicity-induced apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZCH3;Q5NBV8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033106 cis-Golgi network membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QZS5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1B8-2", "uniprot_id": [ { "id": "RORB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1B8", "type": "external" } ], "mass": 53118.0, "length": 470, "protein_name": "Nuclear receptor ROR-beta", "gene_name": "Rorb", "organism": "Mouse", "refseq_name": "nuclear receptor ROR-beta isoform 1", "refseq_ac": [ { "id": "NP_001036819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036819", "type": "external" } ], "gene_names_uniprotkb": "Rorb; Nr1f2", "gene_names_refseq": "Nr1f2; RZR-beta; RZRB; Rorbeta; Rorb; hstp", "protein_names_uniprotkb": "Nuclear receptor ROR-beta; Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; Retinoid-related orphan receptor-beta", "protein_names_refseq": "nuclear receptor ROR-beta isoform 1; nuclear receptor ROR-beta; nuclear receptor RZR-beta; nuclear receptor subfamily 1 group F member 2; retinoid-related orphan receptor-beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:225998); (R-MMU-383280)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16574740;17303680;19805139;20173027;21799210;22189870;23652001;25428506;29187734;9670004", "class_list": "", "function": "Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4., [UniProtKB, PubMed]; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0PQZ2;Q0PQZ3;Q1MVR9", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R1B8-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDT9-1", "uniprot_id": [ { "id": "RM50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDT9", "type": "external" } ], "mass": 18213.0, "length": 159, "protein_name": "Large ribosomal subunit protein mL50", "gene_name": "Mrpl50", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL50", "refseq_ac": [ { "id": "NP_848718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848718", "type": "external" } ], "gene_names_uniprotkb": "Mrpl50", "gene_names_refseq": "D4Wsu125e; Mrpl50", "protein_names_uniprotkb": "Large ribosomal subunit protein mL50; 39S ribosomal protein L50, mitochondrial; L50mt; MRP-L50", "protein_names_refseq": "39S ribosomal protein L50, mitochondrial; L50mt; MRP-L50; large ribosomal subunit protein mL50", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:28028); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CR44", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VDT9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEB6-1", "uniprot_id": [ { "id": "RNZ1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEB6", "type": "external" } ], "mass": 39740.0, "length": 362, "protein_name": "Zinc phosphodiesterase ELAC protein 1", "gene_name": "Elac1", "organism": "Mouse", "refseq_name": "zinc phosphodiesterase ELAC protein 1", "refseq_ac": [ { "id": "NP_444485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444485", "type": "external" } ], "gene_names_uniprotkb": "Elac1", "gene_names_refseq": "2610018O07Rik; 8430417G19Rik; Elac1", "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 1; 3.1.26.11; ElaC homolog protein 1; RNase Z 1; Ribonuclease Z 1; tRNA 3 endonuclease 1; tRNase Z 1", "protein_names_refseq": "RNase Z 1; elaC homolog 1; elaC homolog protein 1; ribonuclease Z 1; tRNA 3 endonuclease 1; tRNase Z 1; zinc phosphodiesterase ELAC protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:114615)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11175785;36210013", "class_list": "", "function": "Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1. tRNAs are then processed by TRNT1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CXB1;Q9ERF4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity;GO:0004549 tRNA-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0042780 tRNA 3'-end processing;GO:0001680 tRNA 3'-terminal CCA addition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VEB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WD1-1", "uniprot_id": [ { "id": "RPC4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WD1", "type": "external" } ], "mass": 44357.0, "length": 398, "protein_name": "DNA-directed RNA polymerase III subunit RPC4", "gene_name": "Polr3d", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC4", "refseq_ac": [ { "id": "NP_001157554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157554", "type": "external" } ], "gene_names_uniprotkb": "Polr3d; Bn51t", "gene_names_refseq": "2810426M17Rik; 44kDa; BN51T; Polr3d; RPC4; TSBN51", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC4; DNA-directed RNA polymerase III subunit D; RNA polymerase III subunit C4", "protein_names_refseq": "BN51 (BHK21) temperature sensitivity complementing; DNA-directed RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67065); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0T3;Q9CZ02", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91WD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WE3-1", "uniprot_id": [ { "id": "RPP25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WE3", "type": "external" } ], "mass": 21038.0, "length": 199, "protein_name": "Ribonuclease P protein subunit p25", "gene_name": "Rpp25", "organism": "Mouse", "refseq_name": "ribonuclease P protein subunit p25", "refseq_ac": [ { "id": "NP_598743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598743", "type": "external" } ], "gene_names_uniprotkb": "Rpp25", "gene_names_refseq": "Rpp25", "protein_names_uniprotkb": "Ribonuclease P protein subunit p25; RNase P protein subunit p25", "protein_names_refseq": "RNase P protein subunit p25; ribonuclease P 25 subunit; ribonuclease P 25kDa subunit; ribonuclease P protein subunit p25", "tax_id": 10090, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:102614); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005654 nucleoplasm;GO:0034451 centriolar satellite;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91WE3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921S7-1", "uniprot_id": [ { "id": "RM37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921S7", "type": "external" } ], "mass": 48341.0, "length": 423, "protein_name": "Large ribosomal subunit protein mL37", "gene_name": "Mrpl37", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL37 precursor", "refseq_ac": [ { "id": "NP_079776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079776", "type": "external" } ], "gene_names_uniprotkb": "Mrpl37", "gene_names_refseq": "2300004O14Rik; MRP-L2; Mrpl37; Rpml2", "protein_names_uniprotkb": "Large ribosomal subunit protein mL37; 39S ribosomal protein L37, mitochondrial; L37mt; MRP-L37", "protein_names_refseq": "39S ribosomal protein L37, mitochondrial; L37mt; MRP-L37; large ribosomal subunit protein mL37 precursor; large ribosomal subunit protein mL37; ribosomal protein, mitochondrial, L2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56280); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9343, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q921S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921X6-1", "uniprot_id": [ { "id": "RPC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921X6", "type": "external" } ], "mass": 35652.0, "length": 316, "protein_name": "DNA-directed RNA polymerase III subunit RPC6", "gene_name": "Polr3f", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC6", "refseq_ac": [ { "id": "NP_084039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084039", "type": "external" } ], "gene_names_uniprotkb": "Polr3f", "gene_names_refseq": "2810411G20Rik; 3010019O03Rik; 3110032A07Rik; Polr3f; RPC39; RPC6", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC6; DNA-directed RNA polymerase III subunit F; RNA polymerase III subunit C6", "protein_names_refseq": "DNA-directed RNA polymerase III subunit F; DNA-directed RNA polymerase III subunit RPC6; RNA polymerase III subunit C6", "tax_id": 10090, "disease": "immunodeficiency 101 (Disease Ontology:DOID:0061071)", "pathway": " (mmu:70408); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544K6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q921X6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N90-1", "uniprot_id": [ { "id": "RM36_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N90", "type": "external" } ], "mass": 11545.0, "length": 102, "protein_name": "Large ribosomal subunit protein bL36m", "gene_name": "Mrpl36", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL36m", "refseq_ac": [ { "id": "NP_444393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444393", "type": "external" } ], "gene_names_uniprotkb": "Mrpl36", "gene_names_refseq": "Mrpl36", "protein_names_uniprotkb": "Large ribosomal subunit protein bL36m; 39S ribosomal protein L36, mitochondrial; L36mt; MRP-L36", "protein_names_refseq": "39S ribosomal protein L36, mitochondrial; L36mt; MRP-L36; large ribosomal subunit protein bL36m", "tax_id": 10090, "disease": "", "pathway": " (mmu:94066); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11279069", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2T6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99N90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N92-1", "uniprot_id": [ { "id": "RM27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N92", "type": "external" } ], "mass": 15945.0, "length": 148, "protein_name": "Large ribosomal subunit protein bL27m", "gene_name": "Mrpl27", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL27m", "refseq_ac": [ { "id": "NP_444391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444391", "type": "external" } ], "gene_names_uniprotkb": "Mrpl27", "gene_names_refseq": "A630055F16Rik; D11Moh47; D18Ertd643e; Mrpl27", "protein_names_uniprotkb": "Large ribosomal subunit protein bL27m; 39S ribosomal protein L27, mitochondrial; L27mt; MRP-L27", "protein_names_refseq": "39S ribosomal protein L27, mitochondrial; L27mt; MRP-L27; large ribosomal subunit protein bL27m", "tax_id": 10090, "disease": "", "pathway": " (mmu:94064); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11279069", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99N92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPW3-1", "uniprot_id": [ { "id": "RM54_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPW3", "type": "external" } ], "mass": 15422.0, "length": 135, "protein_name": "Large ribosomal subunit protein mL54", "gene_name": "Mrpl54", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL54 precursor", "refseq_ac": [ { "id": "NP_079593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079593", "type": "external" } ], "gene_names_uniprotkb": "Mrpl54", "gene_names_refseq": "0610008M19Rik; D10Sut1e; Mrpl54", "protein_names_uniprotkb": "Large ribosomal subunit protein mL54; 39S ribosomal protein L54, mitochondrial; L54mt; MRP-L54", "protein_names_refseq": "39S ribosomal protein L54, mitochondrial; L54mt; MRP-L54; large ribosomal subunit protein mL54 precursor; large ribosomal subunit protein mL54", "tax_id": 10090, "disease": "", "pathway": " (mmu:66047); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CPW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CPY1-1", "uniprot_id": [ { "id": "RM51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CPY1", "type": "external" } ], "mass": 15103.0, "length": 128, "protein_name": "Large ribosomal subunit protein mL51", "gene_name": "Mrpl51", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL51 precursor", "refseq_ac": [ { "id": "NP_079871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079871", "type": "external" } ], "gene_names_uniprotkb": "Mrpl51; Mrp64", "gene_names_refseq": "2610511M02Rik; CDA09; HSPC241; Mrp64; Mrpl51", "protein_names_uniprotkb": "Large ribosomal subunit protein mL51; 39S ribosomal protein L51, mitochondrial; L51mt; MRP-L51; bMRP-64; bMRP64", "protein_names_refseq": "39S ribosomal protein L51, mitochondrial; L51mt; MRP-L51; bMRP-64; bMRP64; large ribosomal subunit protein mL51 precursor; large ribosomal subunit protein mL51; mitochondrial ribosomal protein 64", "tax_id": 10090, "disease": "", "pathway": " (mmu:66493); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11402041;21730110;22872234;31219806;34428180", "class_list": "", "function": "The change in Armet expression lasted while the change of Mrpl51 disappeared after birth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWZ9", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CPY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ29-1", "uniprot_id": [ { "id": "RN151_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ29", "type": "external" } ], "mass": 27175.0, "length": 239, "protein_name": "RING finger protein 151", "gene_name": "Rnf151", "organism": "Mouse", "refseq_name": "RING finger protein 151", "refseq_ac": [ { "id": "NP_080481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080481", "type": "external" } ], "gene_names_uniprotkb": "Rnf151", "gene_names_refseq": "1700010O16Rik; Rnf151", "protein_names_uniprotkb": "RING finger protein 151", "protein_names_refseq": "RING finger protein 151", "tax_id": 10090, "disease": "", "pathway": " (mmu:67504)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17577571;21750661;35831855", "class_list": "", "function": "As dysbindin has lately been shown to be involved in membrane biogenesis and fusion, a key process for acrosome formation, we propose that RNF151 may play a role in acrosome formation., [RefSeq, PubMed]; May be involved in acrosome formation of spermatids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQ29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQZ7-1", "uniprot_id": [ { "id": "RPC10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQZ7", "type": "external" } ], "mass": 12330.0, "length": 108, "protein_name": "DNA-directed RNA polymerase III subunit RPC10", "gene_name": "Polr3k", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC10", "refseq_ac": [ { "id": "NP_080177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080177", "type": "external" } ], "gene_names_uniprotkb": "Polr3k", "gene_names_refseq": "12.3kDa; 1500004O14Rik; C11; Polr3k; RPC10; RPC11", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC10; DNA-directed RNA polymerase III subunit K; RNA polymerase III subunit C10; RNA polymerase III subunit C11; RPC11", "protein_names_refseq": "DNA-directed RNA polymerase III subunit K; DNA-directed RNA polymerase III subunit RPC10; RNA polymerase III subunit C10; RNA polymerase III subunit C11", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 21 (Disease Ontology:DOID:0070407)", "pathway": " (mmu:67005)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30779550", "class_list": "", "function": "Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination (By similarity). Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1U1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CQZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY73-1", "uniprot_id": [ { "id": "RM44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY73", "type": "external" } ], "mass": 37527.0, "length": 333, "protein_name": "Large ribosomal subunit protein mL44", "gene_name": "Mrpl44", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL44 precursor", "refseq_ac": [ { "id": "NP_001074679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074679", "type": "external" } ], "gene_names_uniprotkb": "Mrpl44", "gene_names_refseq": "1810030E18Rik; 5730593H20Rik; Mrpl44", "protein_names_uniprotkb": "Large ribosomal subunit protein mL44; 39S ribosomal protein L44, mitochondrial; L44mt; MRP-L44", "protein_names_refseq": "39S ribosomal protein L44, mitochondrial; L44mt; MRP-L44; large ribosomal subunit protein mL44 precursor; large ribosomal subunit protein mL44", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 16 (Disease Ontology:DOID:0111469)", "pathway": " (mmu:69163); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26221731;31219806", "class_list": "", "function": "Component of the 39S subunit of mitochondrial ribosome (PubMed:26221731). May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0J0;Q8VE61", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0004525 ribonuclease III activity", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006396 RNA processing;GO:0006417 regulation of translation;GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CY73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1H8-1", "uniprot_id": [ { "id": "RM53_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1H8", "type": "external" } ], "mass": 12738.0, "length": 118, "protein_name": "Large ribosomal subunit protein mL53", "gene_name": "Mrpl53", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL53", "refseq_ac": [ { "id": "NP_081020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081020", "type": "external" } ], "gene_names_uniprotkb": "Mrpl53", "gene_names_refseq": "1110007K17Rik; Mrpl53", "protein_names_uniprotkb": "Large ribosomal subunit protein mL53; 39S ribosomal protein L53, mitochondrial; L53mt; MRP-L53", "protein_names_refseq": "39S ribosomal protein L53, mitochondrial; L53mt; MRP-L53; large ribosomal subunit protein mL53", "tax_id": 10090, "disease": "", "pathway": " (mmu:68499); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1H8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2C6-1", "uniprot_id": [ { "id": "RPC8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2C6", "type": "external" } ], "mass": 22948.0, "length": 204, "protein_name": "DNA-directed RNA polymerase III subunit RPC8", "gene_name": "Polr3h", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC8", "refseq_ac": [ { "id": "NP_084505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505", "type": "external" } ], "gene_names_uniprotkb": "Polr3h", "gene_names_refseq": "5031409G22Rik; Polr3h; RPC8", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC8; DNA-directed RNA polymerase III subunit H; RNA polymerase III subunit C7", "protein_names_refseq": "DNA-directed RNA polymerase III subunit H; DNA-directed RNA polymerase III subunit RPC8; RNA polymerase III subunit C7", "tax_id": 10090, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (mmu:78929); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21750661;28341772;30597109;30830215;34428180", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]; Loss-of-function Polr3h mutation in mice caused early embryonic lethality. Mice with homozygous point mutation (Polr3hD50G) were viable but showed delayed pubertal development, characterized by late first estrus or preputial separation. The Polr3hD50G female and male mice showed decreased fertility later in life, associated with small litter size and increased time to pregnancy or to impregnate a female., [RefSeq, PubMed]; Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand., [RefSeq, PubMed]; Pol III transcription during the diurnal cycle is regulated both in response to nutrients and by the circadian clock, which allows anticipatory Pol III transcription., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XE5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005666 RNA polymerase III complex;GO:0005634 nucleus;GO:0000428 DNA-directed RNA polymerase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006139 nucleobase-containing compound metabolic process;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D2C6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D338-1", "uniprot_id": [ { "id": "RM19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D338", "type": "external" } ], "mass": 33578.0, "length": 292, "protein_name": "Large ribosomal subunit protein bL19m", "gene_name": "Mrpl19", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein bL19m", "refseq_ac": [ { "id": "NP_080766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080766", "type": "external" } ], "gene_names_uniprotkb": "Mrpl19", "gene_names_refseq": "9030416F12Rik; 9130412E02Rik; D6Ertd157e; MRP-L15; Mrpl19; RLX1; Rpml15", "protein_names_uniprotkb": "Large ribosomal subunit protein bL19m; 39S ribosomal protein L19, mitochondrial; L19mt; MRP-L19", "protein_names_refseq": "39S ribosomal protein L19, mitochondrial; L19mt; MRP-L19; large ribosomal subunit protein bL19m; ribosomal protein, mitochondrial, L15", "tax_id": 10090, "disease": "", "pathway": " (mmu:56284); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543I0;Q8R1R0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005761 mitochondrial ribosome", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D338-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D483-1", "uniprot_id": [ { "id": "RPC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D483", "type": "external" } ], "mass": 60706.0, "length": 533, "protein_name": "DNA-directed RNA polymerase III subunit RPC3", "gene_name": "Polr3c", "organism": "Mouse", "refseq_name": "DNA-directed RNA polymerase III subunit RPC3", "refseq_ac": [ { "id": "NP_083201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083201", "type": "external" } ], "gene_names_uniprotkb": "Polr3c", "gene_names_refseq": "4933407E01Rik; Polr3c; RPC3; RPC62", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC3; DNA-directed RNA polymerase III subunit C; RNA polymerase III subunit C3", "protein_names_refseq": "DNA-directed RNA polymerase III subunit C; DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74414); (R-MMU-76061); (R-MMU-76066); (R-MMU-76071)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21750661;30084848;31219806;34428180", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0I2", "ec_number_list": [], "go_molecular_function": "GO:0003697 single-stranded DNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006386 termination of RNA polymerase III transcription;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D483-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4G9-1", "uniprot_id": [ { "id": "RMI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4G9", "type": "external" } ], "mass": 68465.0, "length": 616, "protein_name": "RecQ-mediated genome instability protein 1", "gene_name": "Rmi1", "organism": "Mouse", "refseq_name": "recQ-mediated genome instability protein 1", "refseq_ac": [ { "id": "NP_001161720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161720", "type": "external" } ], "gene_names_uniprotkb": "Rmi1", "gene_names_refseq": "4932432N11Rik; Rmi1", "protein_names_uniprotkb": "RecQ-mediated genome instability protein 1", "protein_names_refseq": "RMI1, RecQ mediated genome instability 1, homolog; recQ-mediated genome instability protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:74386); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;20050919;21229605;21432623;23900276;30084848;31219806;34428180", "class_list": "", "function": "Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity)., [UniProtKB]; Glucose regulates RMI1 expression through the E2F pathways in adipose cells., [RefSeq, PubMed]; Results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development, [RefSeq, PubMed]; Results suggest that the regulation of energy balance by RMI1 is attributable to the regulation of food intake and E2F8 expression in adipose tissue., [RefSeq, PubMed]; These results demonstrated a dual-role of RMI1 in embryonic development and tumor suppression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8C560;Q8CI20", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0035264 multicellular organism growth;GO:0006260 DNA replication;GO:0042593 glucose homeostasis;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9D4G9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D706-1", "uniprot_id": [ { "id": "RPAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D706", "type": "external" } ], "mass": 74096.0, "length": 660, "protein_name": "RNA polymerase II-associated protein 3", "gene_name": "Rpap3", "organism": "Mouse", "refseq_name": "RNA polymerase II-associated protein 3", "refseq_ac": [ { "id": "NP_082279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279", "type": "external" } ], "gene_names_uniprotkb": "Rpap3; D15Ertd682e", "gene_names_refseq": "2310042P20Rik; D15Ertd682e; Rpap3", "protein_names_uniprotkb": "RNA polymerase II-associated protein 3", "protein_names_refseq": "RNA polymerase II-associated protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71919)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17242355;18299400;20484733;21183079;21952136;25428506;25605945;27802388;30084848;30779550;34428180", "class_list": "", "function": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005829 cytosol;GO:0005929 cilium;GO:0001669 acrosomal vesicle;GO:0036064 ciliary basal body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D706-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7D1-1", "uniprot_id": [ { "id": "RN225_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7D1", "type": "external" } ], "mass": 35839.0, "length": 332, "protein_name": "RING finger protein 225", "gene_name": "Rnf225", "organism": "Mouse", "refseq_name": "RING finger protein 225", "refseq_ac": [ { "id": "NP_084085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084085", "type": "external" } ], "gene_names_uniprotkb": "Rnf225", "gene_names_refseq": "2310014L17Rik; Rnf225", "protein_names_uniprotkb": "RING finger protein 225", "protein_names_refseq": "RING finger protein 225", "tax_id": 10090, "disease": "", "pathway": " (mmu:381845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D7D1-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCN7-1", "uniprot_id": [ { "id": "RNFT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCN7", "type": "external" } ], "mass": 45277.0, "length": 395, "protein_name": "E3 ubiquitin-protein ligase RNFT1", "gene_name": "Rnft1", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNFT1", "refseq_ac": [ { "id": "NP_084064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084064", "type": "external" } ], "gene_names_uniprotkb": "Rnft1", "gene_names_refseq": "0610013E23Rik; Rnft1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNFT1; 2.3.2.27; RING finger and transmembrane domain-containing protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase RNFT1; RING finger and transmembrane domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76892)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17074343;25428506;27485036;30084848;30779550;31599954;34203471;34428180;35820727", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U649;Q80X62", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031901 early endosome membrane", "go_biological_process": "GO:0051865 protein autoubiquitination;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9DCN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQI8-1", "uniprot_id": [ { "id": "RM46_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQI8", "type": "external" } ], "mass": 32132.0, "length": 283, "protein_name": "Large ribosomal subunit protein mL46", "gene_name": "Mrpl46", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein mL46", "refseq_ac": [ { "id": "NP_075820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075820", "type": "external" } ], "gene_names_uniprotkb": "Mrpl46", "gene_names_refseq": "3110052F15Rik; C15orf4; LIECG2; Mrpl46; P2ECSL", "protein_names_uniprotkb": "Large ribosomal subunit protein mL46; 39S ribosomal protein L46, mitochondrial; L46mt; MRP-L46", "protein_names_refseq": "39S ribosomal protein L46, mitochondrial; L46mt; MRP-L46; large ribosomal subunit protein mL46", "tax_id": 10090, "disease": "", "pathway": " (mmu:67308); (R-MMU-5389840); (R-MMU-5419276); (R-MMU-9937383)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11761714;23806337;31219806;34428180;37507081", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EQI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJH1-1", "uniprot_id": [ { "id": "RNAS4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJH1", "type": "external" } ], "mass": 17025.0, "length": 148, "protein_name": "Ribonuclease 4", "gene_name": "Rnase4", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnase4", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonuclease 4; 3.1.27.-; RNase 4", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "30418175", "class_list": "", "function": "Cleaves preferentially after uridine bases (By similarity). Has antimicrobial activity against uropathogenic E.coli (UPEC) (PubMed:30418175). Probably contributes to urinary tract sterility (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJH1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJI8-1", "uniprot_id": [ { "id": "RL38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJI8", "type": "external" } ], "mass": 8204.0, "length": 70, "protein_name": "Large ribosomal subunit protein eL38", "gene_name": "Rpl38", "organism": "Mouse", "refseq_name": "large ribosomal subunit protein eL38", "refseq_ac": [ { "id": "NP_001041522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041522", "type": "external" } ], "gene_names_uniprotkb": "Rpl38", "gene_names_refseq": "0610025G13Rik; Rbt; Rpl38; Tss; Ts", "protein_names_uniprotkb": "Large ribosomal subunit protein eL38; 60S ribosomal protein L38", "protein_names_refseq": "60S ribosomal protein L38; large ribosomal subunit protein eL38", "tax_id": 10090, "disease": "otitis media (Disease Ontology:DOID:10754)", "pathway": " (mmu:67671); (R-MMU-156827); (R-MMU-1799339); (R-MMU-6791226); (R-MMU-72689); (R-MMU-72706); (R-MMU-975956); (R-MMU-975957); (R-MMU-9954709); (R-MMU-9954714); (R-MMU-9954716)", "pathway_count": 11, "publication_count": 12, "publication_id_list": "21062742;25605945;28315936;30779550;31219806;34428180;35596790;35820727;36517592;37453647;37507081;37828378", "class_list": "", "function": "Component of the large ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592)., [UniProtKB, PubMed]; Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse., [RefSeq, PubMed]; RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0001501 skeletal system development;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JJI8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYM5-1", "uniprot_id": [ { "id": "RND2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QYM5", "type": "external" } ], "mass": 25399.0, "length": 227, "protein_name": "Rho-related GTP-binding protein RhoN", "gene_name": "Rnd2", "organism": "Mouse", "refseq_name": "rho-related GTP-binding protein RhoN", "refseq_ac": [ { "id": "NP_033838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033838", "type": "external" } ], "gene_names_uniprotkb": "Rnd2; Arhn; Rho7; Rhon", "gene_names_refseq": "Arhn; Rnd2; Rohn; rho7", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoN; 3.6.5.2; Rho family GTPase 2; Rho-related GTP-binding protein Rho7; Rnd2", "protein_names_refseq": "aplysia ras-related homolog N (RhoN); ras homolog N (RhoN); ras homolog gene family, member N; rho-related GTP-binding protein Rho7; rho-related GTP-binding protein RhoN", "tax_id": 10090, "disease": "", "pathway": " (mmu:11858); (R-MMU-9696270)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10101234;18690213;19136556;33596091;34561615", "class_list": "", "function": "May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity)., [UniProtKB]; Results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration, [RefSeq, PubMed]; Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity., [RefSeq, PubMed]; Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods., [RefSeq, PubMed]; The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35279", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0007264 small GTPase-mediated signal transduction;GO:0048672 positive regulation of collateral sprouting", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QYM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZS2-1", "uniprot_id": [ { "id": "RNF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZS2", "type": "external" } ], "mass": 21911.0, "length": 194, "protein_name": "E3 ubiquitin-protein ligase RNF4", "gene_name": "Rnf4", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase RNF4", "refseq_ac": [ { "id": "NP_001291198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291198", "type": "external" } ], "gene_names_uniprotkb": "Rnf4", "gene_names_refseq": "Gtrgeo8; Rnf4; SNURF", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF4; 2.3.2.27; RING finger protein 4", "protein_names_refseq": "E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; RING-type E3 ubiquitin transferase RNF4", "tax_id": 10090, "disease": "Angelman syndrome (Disease Ontology:DOID:1932)", "pathway": " (mmu:19822); (R-MMU-5693607); (R-MMU-983168)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10822263;10849425;11866449;12885770;17242355;19779455;20681948;21183079;21750661;34071450;38530355;9479498", "class_list": "", "function": "E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:20681948). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (By similarity). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (By similarity). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity)., [UniProtKB, UniProtKB, PubMed]; GC-rich elements flanking the transcription start site govern activation, [RefSeq, PubMed]; RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication. Publication Status: Online-Only, [RefSeq, PubMed]; The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-alpha-Induced Cell Death Triggered by RIPK1. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35941;Q541Z6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071394 cellular response to testosterone stimulus;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9QZS2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2I4-3", "uniprot_id": [ { "id": "ROBO3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2I4", "type": "external" } ], "mass": 149899.0, "length": 1402, "protein_name": "Roundabout homolog 3", "gene_name": "Robo3", "organism": "Mouse", "refseq_name": "roundabout homolog 3", "refseq_ac": [ { "id": "NP_001158239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158239", "type": "external" } ], "gene_names_uniprotkb": "Robo3; Rbig1", "gene_names_refseq": "Rbig1; Rig-1; Rig1; Robo3a; Robo3b; Robo3", "protein_names_uniprotkb": "Roundabout homolog 3; Retinoblastoma-inhibiting gene 1 protein; Rig-1; Roundabout guidance receptor 3", "protein_names_refseq": "retinoblastoma inhibiting gene 1; retinoblastoma-inhibiting gene 1 protein; roundabout homolog 3", "tax_id": 10090, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475)", "pathway": " (mmu:19649)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;10049565;12200151;14678835;15084255;18466743;25433640;26586761;30843071;32198364", "class_list": "", "function": "After midline crossing by the commissural axons, may, in concert with ROBO1 and ROBO2, prevent midline recrossing. Does not mediate NELL2 signaling., [UniProtKB, PubMed, PubMed]; Mediates NELL2 premature repulsion of commissural axons during midline crossing., [UniProtKB, PubMed, PubMed]; Pax-2/RB binding reverses repression of Rig-1 protein., [RefSeq, PubMed]; Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction (PubMed:15084255, PubMed:18466743, PubMed:25433640, PubMed:30843071). In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2 (PubMed:15084255, PubMed:18466743). Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline (PubMed:30843071, PubMed:32198364). ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself (PubMed:25433640)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1SU85;D3Z4M6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0006935 chemotaxis;GO:0016199 axon midline choice point recognition;GO:0001764 neuron migration;GO:0007411 axon guidance;GO:0071679 commissural neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9Z2I4-3", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0H7-1", "uniprot_id": [ { "id": "S45A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0H7", "type": "external" } ], "mass": 59742.0, "length": 553, "protein_name": "Solute carrier family 45 member 3", "gene_name": "Slc45a3", "organism": "Mouse", "refseq_name": "solute carrier family 45 member 3", "refseq_ac": [ { "id": "NP_001171099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171099", "type": "external" } ], "gene_names_uniprotkb": "Slc45a3; Pcanap6; Prst", "gene_names_refseq": "2210413P12Rik; IPCA-6; PRST; Pcanap6; Slc45a3", "protein_names_uniprotkb": "Solute carrier family 45 member 3; Prostate cancer-associated protein 6; Prostein", "protein_names_refseq": "Prostein; prostate cancer-associated protein 6; solute carrier family 45 member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:212980); (R-MMU-189200)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14561649;21750661;22521588;25164149;30084848", "class_list": "", "function": "Our data suggest that miR-32 and its downstream target SLC45A3 play important roles in myelin maintenance, [RefSeq, PubMed]; Proton-associated sucrose transporter. May be able to transport also glucose and fructose., [UniProtKB, PubMed]; Real-time PCR of mouse tissues confirmed mRNA expression of SLC45A2 in eyes and skin and of SLC45A3 primarily in the prostate, but also in other tissues, whereas SLC45A4 showed a predominantly ubiquitous expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K252;Q8R1I0", "ec_number_list": [], "go_molecular_function": "GO:0008506 sucrose:proton symporter activity;GO:0015291 secondary active transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0010907 positive regulation of glucose metabolic process;GO:0045723 positive regulation of fatty acid biosynthetic process;GO:0015770 sucrose transport;GO:0048713 regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K0H7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH34-1", "uniprot_id": [ { "id": "SEM3D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH34", "type": "external" } ], "mass": 89549.0, "length": 777, "protein_name": "Semaphorin-3D", "gene_name": "Sema3d", "organism": "Mouse", "refseq_name": "semaphorin-3D precursor", "refseq_ac": [ { "id": "NP_083158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083158", "type": "external" } ], "gene_names_uniprotkb": "Sema3d", "gene_names_refseq": "4631426B19Rik; Sema3d", "protein_names_uniprotkb": "Semaphorin-3D", "protein_names_refseq": "semaphorin-3D precursor; semaphorin-3D", "tax_id": 10090, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (mmu:108151)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;28011936;30084848;37219490;39413197", "class_list": "", "function": "Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity)., [UniProtKB]; Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming., [RefSeq, PubMed]; Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BH34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4D8-1", "uniprot_id": [ { "id": "SC5A6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4D8", "type": "external" } ], "mass": 68511.0, "length": 634, "protein_name": "Sodium-dependent multivitamin transporter", "gene_name": "Slc5a6", "organism": "Mouse", "refseq_name": "sodium-dependent multivitamin transporter", "refseq_ac": [ { "id": "NP_001171092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171092", "type": "external" } ], "gene_names_uniprotkb": "Slc5a6", "gene_names_refseq": "E430023I20; Slc5a6", "protein_names_uniprotkb": "Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6", "protein_names_refseq": "Na(+)-dependent multivitamin transporter; sodium-dependent multivitamin transporter; solute carrier family 5 member 6", "tax_id": 10090, "disease": "vitamin metabolic disorder (Disease Ontology:DOID:0050718)", "pathway": " (mmu:330064); (R-MMU-196780); (R-MMU-199220); (R-MMU-425397)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "19144319;21750661;22872234;23104561;27492331;28052864;30084848;30779550;31219806;34428180", "class_list": "", "function": "Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:23104561). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (By similarity). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:23104561). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (PubMed:27492331). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; These studies also provide evidence for a casual association between SMVT function and normal intestinal health, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTU3", "ec_number_list": [], "go_molecular_function": "GO:0008523 sodium-dependent multivitamin transmembrane transporter activity;GO:0090482 vitamin transmembrane transporter activity;GO:0015111 iodide transmembrane transporter activity;GO:0015225 biotin transmembrane transporter activity;GO:0015233 pantothenate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015878 biotin transport;GO:0015887 pantothenate transmembrane transport;GO:0006768 biotin metabolic process;GO:0006814 sodium ion transport;GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5U4D8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LS3-1", "uniprot_id": [ { "id": "SERB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LS3", "type": "external" } ], "mass": 25096.0, "length": 225, "protein_name": "Phosphoserine phosphatase", "gene_name": "Psph", "organism": "Mouse", "refseq_name": "phosphoserine phosphatase", "refseq_ac": [ { "id": "NP_598661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598661", "type": "external" } ], "gene_names_uniprotkb": "Psph", "gene_names_refseq": "PSPase; PSP; Psph", "protein_names_uniprotkb": "Phosphoserine phosphatase; 3.1.3.3; O-phosphoserine phosphohydrolase; PSPase; PSP", "protein_names_refseq": "O-phosphoserine phosphohydrolase; phosphoserine phosphatase", "tax_id": 10090, "disease": "PSPH deficiency (Disease Ontology:DOID:0050724); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:100678); (R-MMU-977347)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17495110;21750661;25153642;36639869;38573412", "class_list": "", "function": "ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH., [RefSeq, PubMed]; Augmented Mitochondrial Transfer Involved in Astrocytic PSPH Attenuates Cognitive Dysfunction in db/db Mice., [RefSeq, PubMed]; Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine., [UniProtKB, UniProtKB]; PSP has a role in neural stem cell proliferation and may regulate signaling between neural stem cells and other cells within the stem cell niche., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TI16;Q5XHW3", "ec_number_list": [ { "id": "3.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.3", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0036424 L-phosphoserine phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0031667 response to nutrient levels;GO:0009612 response to mechanical stimulus;GO:0033574 response to testosterone;GO:0006563 L-serine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99LS3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UJ9-1", "uniprot_id": [ { "id": "SETMR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UJ9", "type": "external" } ], "mass": 34417.0, "length": 309, "protein_name": "Histone-lysine N-methyltransferase SETMAR", "gene_name": "Setmar", "organism": "Mouse", "refseq_name": "histone-lysine N-methyltransferase SETMAR isoform 1", "refseq_ac": [ { "id": "NP_848478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848478", "type": "external" } ], "gene_names_uniprotkb": "Setmar", "gene_names_refseq": "5830404F24Rik; Etet2; Setmar", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETMAR; 2.1.1.357; SET domain without mariner transposase fusion protein", "protein_names_refseq": "SET domain and mariner transposase fusion gene-containing protein homolog; SET domain without mariner transposase fusion protein; epidermal tumor expressed transcript 2; histone-lysine N-methyltransferase SETMAR isoform 1; histone-lysine N-methyltransferase SETMAR", "tax_id": 10090, "disease": "", "pathway": " (mmu:74729)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20620605;21750661;23964856;34428180", "class_list": "", "function": "Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'., [UniProtKB, UniProtKB]; Metnase may have been selected for because it has a function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity., [RefSeq, PubMed]; The suppression of Notch-1 led to increased expression of Oct4 and Sox2, but in decreased gene expression of cMET, Setmar and CD44., [RefSeq, PubMed]; This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Jan 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLD6", "ec_number_list": [ { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0044774 mitotic DNA integrity checkpoint signaling;GO:2001251 negative regulation of chromosome organization;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80UJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZC8-1", "uniprot_id": [ { "id": "SCRN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZC8", "type": "external" } ], "mass": 46326.0, "length": 414, "protein_name": "Secernin-1", "gene_name": "Scrn1", "organism": "Mouse", "refseq_name": "secernin-1 isoform a", "refseq_ac": [ { "id": "NP_081544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081544", "type": "external" } ], "gene_names_uniprotkb": "Scrn1; Kiaa0193", "gene_names_refseq": "2810019K23Rik; 6330535A03Rik; SES1; Scrn1; mKIAA0193", "protein_names_uniprotkb": "Secernin-1", "protein_names_refseq": "secernin-1 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:69938)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;29273527;33442887;36437381", "class_list": "", "function": "Axonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1., [RefSeq, PubMed]; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity)., [UniProtKB]; The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse., [RefSeq, PubMed]; While acute aerobic exercise increased Sesn1 accumulation and induced a discrete augment of Sesn2 protein content and AMPK threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 and Sesn2 as well as of AMPK threonine phosphorylation in the quadriceps muscles of C57BL/6J mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKR2;Q8CCL3", "ec_number_list": [], "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006508 proteolysis;GO:0006887 exocytosis;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CZC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78KK3-1", "uniprot_id": [ { "id": "S67A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78KK3", "type": "external" } ], "mass": 43013.0, "length": 406, "protein_name": "Solute carrier family 22 member 18", "gene_name": "Slc22a18; Slc67a1", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 18 isoform b", "refseq_ac": [ { "id": "NP_001036225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036225", "type": "external" } ], "gene_names_uniprotkb": "Slc22a18; Slc67a1; Impt1; Itm; Orctl2; Slc22a18; Tssc5", "gene_names_refseq": "BWR1A; BWSCR1A; HET; ITM; Impt1; Orctl2; Slc22a18; Slc22a1l; Slc67a1; TSSC5; p45-BWR1A", "protein_names_uniprotkb": "Solute carrier family 22 member 18; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; Multi-membrane-spanning polyspecific transporter; ORCTL-2; Organic cation transporter-like protein 2", "protein_names_refseq": "ORCTL-2; imprinted multi-membrane spanning polyspecific transporter-related protein 1; organic cationic transporter-like 2; solute carrier family 22 (organic cation transporter), member 18; solute carrier family 22 member 18 isoform b; solute carrier family 22 member 18; tumor suppressing subtransferable candidate 5", "tax_id": 10090, "disease": "lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914)", "pathway": " (mmu:18400); (R-MMU-549127)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11063728;21750661;25428506;30084848;34428180;35820727;37453647;38626531;9499412;9570947;9802569", "class_list": "", "function": "May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). Plays a role in the regulation of lipid metabolism (PubMed:38626531)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Overexpression of Slc22a18 facilitates fat accumulation in mice., [RefSeq, PubMed]; Slc22a18/Itm gene is imprinted, with preferential expression from the maternal allele in fetal, newborn and most adult tissues, but biallelic expression in adult kidney and liver., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35428;O54959;O88283;Q99NF4", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016324 apical plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q78KK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FF9-1", "uniprot_id": [ { "id": "S5A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q68FF9", "type": "external" } ], "mass": 29344.0, "length": 255, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "gene_name": "Srd5a1", "organism": "Mouse", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "refseq_ac": [ { "id": "NP_780492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780492", "type": "external" } ], "gene_names_uniprotkb": "Srd5a1", "gene_names_refseq": "0610031P22Rik; 4930435F02Rik; S5AR 1; Srd5a-1; Srd5a1", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; 1.3.1.22; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; type 1 5alpha-reductase", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); hyperprolactinemia (Disease Ontology:DOID:12700); hypothyroidism (Disease Ontology:DOID:1459); breast carcinoma (Disease Ontology:DOID:3459); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:78925); (R-MMU-193048)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;34428180;36465608", "class_list": "", "function": "A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms. Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development. Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles. Hence, it plays a central role in sexual differentiation and androgen physiology., [UniProtKB, UniProtKB]; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505K7", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0033218 amide binding;GO:0070402 NADPH binding;GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0070852 cell body fiber", "go_biological_process": "GO:0006710 androgen catabolic process;GO:0030154 cell differentiation;GO:0008584 male gonad development;GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1C1-1", "uniprot_id": [ { "id": "SAPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1C1", "type": "external" } ], "mass": 57061.0, "length": 522, "protein_name": "Proactivator polypeptide-like 1", "gene_name": "Psapl1", "organism": "Mouse", "refseq_name": "proactivator polypeptide-like 1 precursor", "refseq_ac": [ { "id": "NP_780458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780458", "type": "external" } ], "gene_names_uniprotkb": "Psapl1", "gene_names_refseq": "2310020A21Rik; Psapl1", "protein_names_uniprotkb": "Proactivator polypeptide-like 1", "protein_names_refseq": "proactivator polypeptide-like 1 precursor; proactivator polypeptide-like 1", "tax_id": 10090, "disease": "combined saposin deficiency (Disease Ontology:DOID:0111330)", "pathway": " (mmu:76943)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16170054;21750661;30084848;34428180", "class_list": "", "function": "May activate the lysosomal degradation of sphingolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJV5;Q8C1N0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:0005576 extracellular region", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0006665 sphingolipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0060736 prostate gland growth;GO:0060742 epithelial cell differentiation involved in prostate gland development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8C1C1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXT9-1", "uniprot_id": [ { "id": "SC22C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXT9", "type": "external" } ], "mass": 33913.0, "length": 303, "protein_name": "Vesicle-trafficking protein SEC22c", "gene_name": "Sec22c", "organism": "Mouse", "refseq_name": "vesicle-trafficking protein SEC22c", "refseq_ac": [ { "id": "NP_001158034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158034", "type": "external" } ], "gene_names_uniprotkb": "Sec22c; Sec22l3", "gene_names_refseq": "4932412K21; 5930407I15Rik; C530046H07; Sec22c; Sec22l3", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22c; SEC22 vesicle trafficking protein-like 3; SEC22 vesicle-trafficking protein homolog C", "protein_names_refseq": "SEC22 vesicle trafficking protein homolog C; SEC22 vesicle trafficking protein-like 3; SEC22 vesicle trafficking protein-like C; vesicle-trafficking protein SEC22c", "tax_id": 10090, "disease": "", "pathway": " (mmu:215474); (R-MMU-204005)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "May be involved in vesicle transport between the ER and the Golgi complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMH4;Q8C0R8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BXT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88822-1", "uniprot_id": [ { "id": "SC5D_MOUSE", "url": "https://www.uniprot.org/uniprot/O88822", "type": "external" } ], "mass": 35062.0, "length": 299, "protein_name": "Lathosterol oxidase", "gene_name": "Sc5d", "organism": "Mouse", "refseq_name": "lathosterol oxidase", "refseq_ac": [ { "id": "NP_766357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766357", "type": "external" } ], "gene_names_uniprotkb": "Sc5d; Sc5dl", "gene_names_refseq": "A830037K02; A830073K23Rik; Sc5dl; Sc5d", "protein_names_uniprotkb": "Lathosterol oxidase; 1.14.19.20; C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Delta(7)-sterol C5(6)-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase", "protein_names_refseq": "C-5 sterol desaturase; delta(7)-sterol 5-desaturase; delta(7)-sterol C5(6)-desaturase; lathosterol 5-desaturase; lathosterol oxidase; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:235293); (R-MMU-6807047)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10786622;21750661;30084848;31219806;34428180;38086515", "class_list": "", "function": "Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death., [UniProtKB, UniProtKB]; Loss of Sc5d results in micrognathia due to a failure in osteoblast differentiation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGI0", "ec_number_list": [ { "id": "1.14.19.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.20", "type": "external" } ], "go_molecular_function": "GO:0000248 C-5 sterol desaturase activity;GO:0005506 iron ion binding;GO:0050046 delta7-sterol 5(6)-desaturase activity;GO:0070704 sterol desaturase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol;GO:0110076 negative regulation of ferroptosis;GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88822-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERN0-1", "uniprot_id": [ { "id": "SCAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ERN0", "type": "external" } ], "mass": 36465.0, "length": 329, "protein_name": "Secretory carrier-associated membrane protein 2", "gene_name": "Scamp2", "organism": "Mouse", "refseq_name": "secretory carrier-associated membrane protein 2 isoform 2", "refseq_ac": [ { "id": "NP_073724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073724", "type": "external" } ], "gene_names_uniprotkb": "Scamp2", "gene_names_refseq": "Sc2; Scamp2", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 2; Secretory carrier membrane protein 2", "protein_names_refseq": "secretory carrier-associated membrane protein 2 isoform 2; secretory carrier-associated membrane protein 2", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (mmu:24044)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11050114;21205824;21750661;26495903;26740625;28011936;28935714;34428180", "class_list": "", "function": "Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity)., [UniProtKB]; SCAMP2 regulates NKCC2 transit through recycling endosomes and limits the cell surface targeting of the co-transporter by interfering with its exocytotic trafficking., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0055038 recycling endosome membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ERN0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59708-1", "uniprot_id": [ { "id": "SF3B6_MOUSE", "url": "https://www.uniprot.org/uniprot/P59708", "type": "external" } ], "mass": 14585.0, "length": 125, "protein_name": "Splicing factor 3B subunit 6", "gene_name": "Sf3b6", "organism": "Mouse", "refseq_name": "splicing factor 3B subunit 6", "refseq_ac": [ { "id": "NP_079599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079599", "type": "external" } ], "gene_names_uniprotkb": "Sf3b6; Sf3b14", "gene_names_refseq": "0610009D07Rik; 6030419K15Rik; Sf3b14; Sf3b6", "protein_names_uniprotkb": "Splicing factor 3B subunit 6; Pre-mRNA branch site protein p14; SF3b 14 kDa subunit", "protein_names_refseq": "SF3B 14 kDa subunit; pre-mRNA branch site protein p14; splicing factor 3B subunit 6; splicing factor 3B, 14 kDa subunit", "tax_id": 10090, "disease": "", "pathway": " (mmu:66055)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16452087;21750661;22645316;23211737;24788674;25153642;31219806;34428180", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting-binding of introns with poor sequence complementarity. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]; Sf3b14 is required for the blastocyst formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U9T9", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P59708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36536-1", "uniprot_id": [ { "id": "SAR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P36536", "type": "external" } ], "mass": 22371.0, "length": 198, "protein_name": "Small COPII coat GTPase SAR1A", "gene_name": "Sar1a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sar1a; Sara1; Sara", "gene_names_refseq": "", "protein_names_uniprotkb": "Small COPII coat GTPase SAR1A; 3.6.5.2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "21183079;21750661;25428506;30084848;34203471;8262187", "class_list": "", "function": "Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. The GTPase activity of SAR1 by controlling the timing of COPII budding regulates the size of the formed vesicles and is important for cargo selection depending on their size. Together with SEC16A, forms the organized scaffold defining endoplasmic reticulum exit sites (ERES), some specific domains of the endoplasmic reticulum where COPII vesicles form. In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0140785 amino acid sensor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0061024 membrane organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36536-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IS41-1", "uniprot_id": [ { "id": "S2547_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IS41", "type": "external" } ], "mass": 33646.0, "length": 310, "protein_name": "Solute carrier family 25 member 47", "gene_name": "Slc25a47", "organism": "Mouse", "refseq_name": "solute carrier family 25 member 47", "refseq_ac": [ { "id": "NP_001012310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012310", "type": "external" } ], "gene_names_uniprotkb": "Slc25a47; Hdmcp", "gene_names_refseq": "HDMCP; Slc25a47", "protein_names_uniprotkb": "Solute carrier family 25 member 47; Hepatocellular carcinoma down-regulated mitochondrial carrier homolog; Mitochondrial NAD(+) transporter SLC25A47", "protein_names_refseq": "hepatocellular carcinoma down-regulated mitochondrial carrier homolog; mitochondrial NAD(+) transporter SLC25A47; mitochondrial hepatocellular carcinoma-downregulated carrier protein; solute carrier family 25 member 47", "tax_id": 10090, "disease": "", "pathway": " (mmu:104910)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15322095;21750661;28346483;34428180;35714811;36804859", "class_list": "", "function": "Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis., [RefSeq, PubMed]; Hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein, [RefSeq, PubMed]; Increased HDMCP expression was identified in nonalcoholic steatohepatitis animal model and HFFA-72h cultured L02 cell. Moreover, under regulation of miR-146, nonalcoholic steatohepatitis alleviation was achieved after HDMCP downregulation in both in vivo and in vitro, according to the declination of steatosis and inflammation related markers. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated., [UniProtKB, PubMed]; The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UES2;Q5FW58;Q7TPP3", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008521 acetyl-CoA transmembrane transporter activity;GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IS41-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JL59-1", "uniprot_id": [ { "id": "SCT1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JL59", "type": "external" } ], "mass": 23477.0, "length": 212, "protein_name": "Secreted and transmembrane protein 1b", "gene_name": "Sectm1b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sectm1b; K12; Sectm1", "gene_names_refseq": "", "protein_names_uniprotkb": "Secreted and transmembrane protein 1b; Protein K-12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10652336;21750661;30084848", "class_list": "", "function": "May be involved in thymocyte signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0006955 immune response;GO:0002726 positive regulation of T cell cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JL59-1", "record_type": "protein", "filter_code": "0000000.1000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82347-1", "uniprot_id": [ { "id": "SGCD_MOUSE", "url": "https://www.uniprot.org/uniprot/P82347", "type": "external" } ], "mass": 32133.0, "length": 289, "protein_name": "Delta-sarcoglycan", "gene_name": "Sgcd", "organism": "Mouse", "refseq_name": "delta-sarcoglycan", "refseq_ac": [ { "id": "NP_036021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036021", "type": "external" } ], "gene_names_uniprotkb": "Sgcd", "gene_names_refseq": "35DAG; A530047J11Rik; SG-delta; Sgcd; delta-SG", "protein_names_uniprotkb": "Delta-sarcoglycan; 35 kDa dystrophin-associated glycoprotein; 35DAG; Delta-SG", "protein_names_refseq": "35 kDa dystrophin-associated glycoprotein; delta-sarcoglycan; sarcoglycan, delta (35kD dystrophin-associated glycoprotein)", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2F (Disease Ontology:DOID:0110280); dilated cardiomyopathy 1L (Disease Ontology:DOID:0110436); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:24052); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10448073;21750661;30899004;31689918;36288343;37828378;9864373", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB]; The retinal layers in Sgcd-/- mice are are significantly thinner and five times more likely to have retinal ruptures. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0086003 cardiac muscle cell contraction;GO:0019722 calcium-mediated signaling;GO:0060047 heart contraction;GO:0061024 membrane organization;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P82347-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0S9-1", "uniprot_id": [ { "id": "S22AM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0S9", "type": "external" } ], "mass": 62424.0, "length": 554, "protein_name": "Solute carrier family 22 member 22", "gene_name": "Slc22a22", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 22", "refseq_ac": [ { "id": "NP_759010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_759010", "type": "external" } ], "gene_names_uniprotkb": "Slc22a22; Oat-pg", "gene_names_refseq": "Slc22a22; oat-pg", "protein_names_uniprotkb": "Solute carrier family 22 member 22; Prostaglandin-specific organic anion transporter", "protein_names_refseq": "prostaglandin-specific organic anion transporter; solute carrier family 22 member 22", "tax_id": 10090, "disease": "", "pathway": " (mmu:210463)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20448048;21750661;25428506;35820727", "class_list": "", "function": "OAT-PG is proposed to be involved in the local PGE(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex., [RefSeq, PubMed]; Sodium-independent organic anion transporter which exhibits high specificity for a subset of prostaglandins including prostaglandin E2 (PGE2), prostaglandin E1 (PGE1), prostaglandin F2-alpha (PGF2-alpha) and prostaglandin D2 (PGD2)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004955 prostaglandin receptor activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015711 organic anion transport;GO:0071720 sodium-independent prostaglandin transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R0S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1T4-1", "uniprot_id": [ { "id": "S35A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1T4", "type": "external" } ], "mass": 35976.0, "length": 326, "protein_name": "UDP-N-acetylglucosamine transporter", "gene_name": "Slc35a3", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine transporter isoform 1", "refseq_ac": [ { "id": "NP_659151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659151", "type": "external" } ], "gene_names_uniprotkb": "Slc35a3", "gene_names_refseq": "2310050P13Rik; Slc35a3", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transporter; Golgi UDP-GlcNAc transporter; Solute carrier family 35 member A3", "protein_names_refseq": "UDP-N-acetylglucosamine transporter isoform 1; UDP-N-acetylglucosamine transporter; golgi UDP-GlcNAc transporter", "tax_id": 10090, "disease": "", "pathway": " (mmu:229782); (R-MMU-727802)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21750661;30084848;31118275;31219806;31599954;33300544;34428180;37053259", "class_list": "glycogene", "function": "Cells expressing E47C or K50C mSlc35a3 variants had lower levels of GlcNAc-containing glycoconjugates than WT cells, [RefSeq, PubMed]; Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:31118275). May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (By similarity). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 13, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BRW7", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1990569 UDP-N-acetylglucosamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8R1T4-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0100000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C145-1", "uniprot_id": [ { "id": "S39A6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C145", "type": "external" } ], "mass": 86380.0, "length": 765, "protein_name": "Zinc transporter ZIP6", "gene_name": "Slc39a6", "organism": "Mouse", "refseq_name": "zinc transporter ZIP6 precursor", "refseq_ac": [ { "id": "NP_631882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631882", "type": "external" } ], "gene_names_uniprotkb": "Slc39a6; Zip6", "gene_names_refseq": "Ermelin; Slc39a6; Zip6", "protein_names_uniprotkb": "Zinc transporter ZIP6; Endoplasmic reticulum membrane-linked protein; Ermelin; Solute carrier family 39 member 6; ZIP-6; Zrt- and Irt-like protein 6", "protein_names_refseq": "ZIP-6; endoplasmic reticulum membrane protein; endoplasmic reticulum membrane-linked protein; solute carrier family 39 member 6; zinc transporter ZIP6 precursor; zinc transporter ZIP6; zrt- and Irt-like protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:106957); (R-MMU-442380)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;11891044;19144319;19349973;21248196;21750661;22872234;25143461;25428506;25605945;28098160;30084848;30779550;30899004;31219806;31636012;34203471;34428180", "class_list": "", "function": "Mice fed low-Zn diet had reduced number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells compromised seminiferous tubule structure, and reduced Zip10 and Zip6 abundance (>50%; P < 0.5) compared with control diet, [RefSeq, PubMed]; PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate that LIV-1-GRPEL1 axis dually regulates mitotic exit as well as apoptosis by interacting with PP2A B55alpha and AIF., [RefSeq, PubMed]; Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:28098160). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (By similarity). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (PubMed:28098160). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as E-cadherin, causing loss of cell adherence (By similarity). In addition, the SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (By similarity). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (By similarity). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7TPP9;Q7TQE0;Q8R518", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0046649 lymphocyte activation;GO:0050852 T cell receptor signaling pathway;GO:0001837 epithelial to mesenchymal transition;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q8C145-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBT2-1", "uniprot_id": [ { "id": "SDHL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBT2", "type": "external" } ], "mass": 34593.0, "length": 327, "protein_name": "L-serine dehydratase/L-threonine deaminase", "gene_name": "Sds", "organism": "Mouse", "refseq_name": "L-serine dehydratase/L-threonine deaminase", "refseq_ac": [ { "id": "NP_663540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663540", "type": "external" } ], "gene_names_uniprotkb": "Sds", "gene_names_refseq": "4432411H13Rik; SDH; Sds", "protein_names_uniprotkb": "L-serine dehydratase/L-threonine deaminase; 4.3.1.17; 4.3.1.19; L-serine deaminase; L-threonine dehydratase; SDH; TDH", "protein_names_refseq": "L-serine deaminase; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; TDH", "tax_id": 10090, "disease": "", "pathway": " (mmu:231691); (R-MMU-8849175); (R-MMU-977347)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21750661;22763616;30084848;34428180;37453647", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This persistent conditioned hyperactivity in The SR-/- subjects supports the conclusion that intact NMDA receptor signaling is critical to extinction learning., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.17", "type": "external" }, { "id": "4.3.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.19", "type": "external" }, { "id": "5.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.3", "type": "external" }, { "id": "4.3.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.18", "type": "external" }, { "id": "5.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis;GO:0006567 L-threonine catabolic process;GO:0006565 L-serine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VBT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70122-1", "uniprot_id": [ { "id": "SBDS_MOUSE", "url": "https://www.uniprot.org/uniprot/P70122", "type": "external" } ], "mass": 28781.0, "length": 250, "protein_name": "Ribosome maturation protein SBDS", "gene_name": "Sbds", "organism": "Mouse", "refseq_name": "ribosome maturation protein SBDS", "refseq_ac": [ { "id": "NP_075737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075737", "type": "external" } ], "gene_names_uniprotkb": "Sbds", "gene_names_refseq": "4733401P19Rik; CGI-97; SDS; Sbds", "protein_names_uniprotkb": "Ribosome maturation protein SBDS; Protein 22A3; Shwachman-Bodian-Diamond syndrome protein homolog", "protein_names_refseq": "SBDS ribosome assembly guanine nucleotide exchange factor; Shwachman-Bodian-Diamond syndrome homolog; protein 22A3; ribosome maturation protein SBDS; shwachman-Bodian-Diamond syndrome protein homolog", "tax_id": 10090, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); aplastic anemia (Disease Ontology:DOID:12449)", "pathway": " (mmu:66711)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "16914746;17638857;18832544;19602484;21183079;21536732;21750661;22510201;25605945;26185170;34428180;34625796;39085077", "class_list": "", "function": "Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes, [RefSeq, PubMed]; Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation., [RefSeq, PubMed]; Loss of Sbds is sufficient to induce abnormalities in hematopoiesis, [RefSeq, PubMed]; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; SBDS Gene Mutation Increases ROS Production and Causes DNA Damage as Well as Oxidation of Mitochondrial Membranes in the Murine Myeloid Cell Line 32Dcl3., [RefSeq, PubMed]; Sbds genotypes correlated with phenotypes in a mouse model of Shwachman-Diamond syndrome. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes., [RefSeq, PubMed]; Sbds is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation., [RefSeq, PubMed]; The majority of Shwachman-Diamond syndrome cases are results of mutations in SBDS gene on chromosone 7q11., [RefSeq, PubMed]; This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TG78;Q9CR18", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019843 rRNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0006364 rRNA processing;GO:0030282 bone mineralization;GO:0007052 mitotic spindle organization;GO:0048539 bone marrow development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70122-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84102-1", "uniprot_id": [ { "id": "SERF2_MOUSE", "url": "https://www.uniprot.org/uniprot/P84102", "type": "external" } ], "mass": 6900.0, "length": 59, "protein_name": "Small EDRK-rich factor 2", "gene_name": "Serf2", "organism": "Mouse", "refseq_name": "small EDRK-rich factor 2 isoform b", "refseq_ac": [ { "id": "NP_035484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035484", "type": "external" } ], "gene_names_uniprotkb": "Serf2", "gene_names_refseq": "Msmac1l; Serf2; m4F5rel", "protein_names_uniprotkb": "Small EDRK-rich factor 2; 4F5rel; Protein 4F5-related", "protein_names_refseq": "4F5rel (4F5 related); protein 4F5-related; small EDRK-rich factor 2 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:378702)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20112406;21750661;30059200;33713180;37130781;9731538", "class_list": "", "function": "A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits., [RefSeq, PubMed]; Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Publication Status: Online-Only, [RefSeq, PubMed]; Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates (By similarity)., [UniProtKB, UniProtKB]; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2ARQ3;O75918;O88891;Q9BZH7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P84102-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q31125-1", "uniprot_id": [ { "id": "S39A7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q31125", "type": "external" } ], "mass": 50657.0, "length": 476, "protein_name": "Zinc transporter SLC39A7", "gene_name": "Slc39a7", "organism": "Mouse", "refseq_name": "zinc transporter SLC39A7 precursor", "refseq_ac": [ { "id": "NP_001071177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071177", "type": "external" } ], "gene_names_uniprotkb": "Slc39a7; H2-Ke4; Hke4", "gene_names_refseq": "H-2Ke4; H2-Ke4; Ke-4; Ke4; Ring5; Slc39a7; Zip7", "protein_names_uniprotkb": "Zinc transporter SLC39A7; Histidine-rich membrane protein Ke4; Solute carrier family 39 member 7; ZIP7; Zrt-, Irt-like protein 7", "protein_names_refseq": "H2-K region expressed gene 4; histidine-rich membrane protein Ke4; solute carrier family 39 member 7; zinc transporter SLC39A7 precursor; zinc transporter SLC39A7; zrt-, Irt-like protein 7", "tax_id": 10090, "disease": "agammaglobulinemia 9 (Disease Ontology:DOID:0081141)", "pathway": " (mmu:14977); (R-MMU-442380)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "15705588;21750661;2294398;27736879;28545780;30718914;31219806;31266232;31412620;34218407;34428180;34581906;37828378", "class_list": "", "function": "Study identified that Zip7 is upregulated by glucose in normal skeletal muscle cells and downregulated in insulin-resistant skeletal muscle. The overexpression of Zip7 in skeletal muscle cells led to the modulation of key genes involved in the insulin signaling axis and glucose metabolism. In vivo mouse model revealed a reduction in Glut4 and Zip7 in the skeletal muscle of mice fed a high-fat diet. Publication Status: Online-Only, [RefSeq, PubMed]; The zinc transporter ZIP7 (Slc39a7) controls myocardial reperfusion injury by regulating mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:15705588). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (By similarity). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (PubMed:27736879, PubMed:28545780). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (PubMed:31266232). Has a protective role against ER stress in different biological contexts (PubMed:31266232). Mediates Zn(2+)-induced ferroptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; We have clarified the functional differences between ZIP7 and ZIP13 and show that their different regulation of cellular zinc homeostasis is critical for dermal development and homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVU6;Q9Z1W1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0098773 skin epidermis development;GO:0030183 B cell differentiation;GO:0006882 intracellular zinc ion homeostasis;GO:0110075 regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q31125-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDB9-1", "uniprot_id": [ { "id": "S620A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDB9", "type": "external" } ], "mass": 66178.0, "length": 592, "protein_name": "Sodium- and chloride-dependent transporter XTRP3A", "gene_name": "Slc6a20a", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent transporter XTRP3A", "refseq_ac": [ { "id": "NP_631881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631881", "type": "external" } ], "gene_names_uniprotkb": "Slc6a20a; Slc6a20; Xt3s1; Xtm3s1; Xtrp3s1", "gene_names_refseq": "A730081N20Rik; Slc6a20a; Xt3s1; Xtrp3s1", "protein_names_uniprotkb": "Sodium- and chloride-dependent transporter XTRP3A; IMINO-B; Solute carrier family 6 member 20A; X transporter protein 3 similar 1", "protein_names_refseq": "IMINO-B; X transporter protein 3 similar 1; sodium- and chloride-dependent transporter XTRP3A; solute carrier family 6 member 20A", "tax_id": 10090, "disease": "", "pathway": " (mmu:102680); (R-MMU-352230); (R-MMU-442660)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12461651;15632147;15689184;16174864;19029042;21750661;33428810", "class_list": "", "function": "Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15689184). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810)., [UniProtKB, PubMed, PubMed]; Molecular cloning of two mouse homologues corresponding to the single human SLC6A20 gene: these have been named XT3 and XT3s1 [Xt3s1], [RefSeq, PubMed]; We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3USE2", "ec_number_list": [], "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015370 solute:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:1905647 proline import across plasma membrane;GO:0015824 proline transport;GO:0035524 proline transmembrane transport;GO:1904271 L-proline import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VDB9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SWY8-1", "uniprot_id": [ { "id": "SC5AA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SWY8", "type": "external" } ], "mass": 64706.0, "length": 596, "protein_name": "Sodium/mannose cotransporter SLC5A10", "gene_name": "Slc5a10", "organism": "Mouse", "refseq_name": "sodium/mannose cotransporter SLC5A10", "refseq_ac": [ { "id": "NP_001028399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028399", "type": "external" } ], "gene_names_uniprotkb": "Slc5a10; Sglt5", "gene_names_refseq": "C330021F16Rik; SGLT5; Slc5a10", "protein_names_uniprotkb": "Sodium/mannose cotransporter SLC5A10; Na(+)/glucose cotransporter 5; Sodium/glucose cotransporter 5; Solute carrier family 5 member 10", "protein_names_refseq": "Na(+)/glucose cotransporter 5; sodium/glucose cotransporter 5; sodium/mannose cotransporter SLC5A10; solute carrier family 5 member 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:109342); (R-MMU-189200)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21183079;21750661;23451068;30084848", "class_list": "", "function": "Data show fructose-induced hepatic steatosis was exacerbated in the SGLT5-deficient mice, [RefSeq, PubMed]; Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (By similarity) (PubMed:23451068). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (By similarity) (PubMed:23451068)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B9EJ50", "ec_number_list": [], "go_molecular_function": "GO:0140929 mannose:sodium symporter activity;GO:0140930 fructose:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5SWY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60060-1", "uniprot_id": [ { "id": "SC61G_MOUSE", "url": "https://www.uniprot.org/uniprot/P60060", "type": "external" } ], "mass": 7741.0, "length": 68, "protein_name": "Protein transport protein Sec61 subunit gamma", "gene_name": "Sec61g", "organism": "Mouse", "refseq_name": "protein transport protein Sec61 subunit gamma isoform 2", "refseq_ac": [ { "id": "NP_001103441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103441", "type": "external" } ], "gene_names_uniprotkb": "Sec61g", "gene_names_refseq": "Sec61g", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit gamma", "protein_names_refseq": "SEC61, gamma subunit; protein transport protein Sec61 subunit gamma isoform 2; protein transport protein Sec61 subunit gamma", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:20335); (R-MMU-9609523)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;36759724;37523556", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SEC61G assists EGFR-amplified glioblastoma to evade immune elimination., [RefSeq, PubMed]; Sec61gamma is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P38384", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005784 Sec61 translocon complex;GO:0071261 Ssh1 translocon complex", "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60060-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PN0-1", "uniprot_id": [ { "id": "SC5A5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PN0", "type": "external" } ], "mass": 65568.0, "length": 618, "protein_name": "Sodium/iodide cotransporter", "gene_name": "Slc5a5", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc5a5; Nis", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/iodide cotransporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Sodium-iodide symporter; Solute carrier family 5 member 5", "protein_names_refseq": "", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 1 (Disease Ontology:DOID:0112185)", "pathway": " (mmu:114479); (R-MMU-209968); (R-MMU-9958790)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11716040;18372236;21750661;27802388;31219806;32084174", "class_list": "", "function": "Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:11716040, PubMed:18372236, PubMed:32084174). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B2RPX6", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0015293 symporter activity;GO:0015111 iodide transmembrane transporter activity;GO:0008507 sodium:iodide symporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1904322 cellular response to forskolin;GO:0015705 iodide transport;GO:0006814 sodium ion transport;GO:0006590 thyroid hormone generation;GO:1904401 cellular response to Thyroid stimulating hormone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99PN0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER60-1", "uniprot_id": [ { "id": "SCN4A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER60", "type": "external" } ], "mass": 208798.0, "length": 1841, "protein_name": "Sodium channel protein type 4 subunit alpha", "gene_name": "Scn4a", "organism": "Mouse", "refseq_name": "sodium channel protein type 4 subunit alpha", "refseq_ac": [ { "id": "NP_573462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573462", "type": "external" } ], "gene_names_uniprotkb": "Scn4a", "gene_names_refseq": "Nav1.4; Scn4a; SkM1; mH2", "protein_names_uniprotkb": "Sodium channel protein type 4 subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type IV subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.4", "protein_names_refseq": "sodium channel alpha-subunit; sodium channel protein skeletal muscle subunit alpha; sodium channel protein type 4 subunit alpha; sodium channel protein type IV subunit alpha; sodium channel, voltage-gated, type IV, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.4", "tax_id": 10090, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); Dravet syndrome (Disease Ontology:DOID:0080422); congenital myopathy 22A (Disease Ontology:DOID:0081354); congenital myopathy 22B (Disease Ontology:DOID:0081355); congenital myasthenic syndrome 16 (Disease Ontology:DOID:0110682); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); paramyotonia congenita of Von Eulenburg (Disease Ontology:DOID:0111538); hyperkalemic periodic paralysis (Disease Ontology:DOID:14451); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:110880)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11834499;18317596;18625851;21750661;21881211;26427606;29509900;31219806;35759432;35820727;36210013;9412493", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:11834499). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (PubMed:18317596, PubMed:21881211)., [UniProtKB, PubMed, PubMed, PubMed]; Voltage-dependent Ca(2+) release is impaired in hypokalemic periodic paralysis caused by CaV1.1-R528H but not by NaV1.4-R669H., [RefSeq, PubMed]; We performed an unbiased mutagenesis screen on an HD mouse model, identifying a mutation in the skeletal muscle voltage-gated sodium channel (Scn4a, termed 'draggen' mutation) as a novel disease enhancer, [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 10, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "A2VDE9;B1ARK0", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0006812 monoatomic cation transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ER60-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWI2-1", "uniprot_id": [ { "id": "SCTR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWI2", "type": "external" } ], "mass": 50932.0, "length": 447, "protein_name": "Secretin receptor", "gene_name": "Sctr", "organism": "Mouse", "refseq_name": "secretin receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_001012322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012322", "type": "external" } ], "gene_names_uniprotkb": "Sctr", "gene_names_refseq": "6530402O03Rik; Sctr", "protein_names_uniprotkb": "Secretin receptor; SCT-R", "protein_names_refseq": "SCT-R; secretin receptor isoform 1 precursor", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:319229); (R-MMU-418555); (R-MMU-420092)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12679517;17008357;17283064;20578263;20739612;20927047;21750661;24273196;24769669;30449620;35051436;36220076;37344929;37774845", "class_list": "", "function": "Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice., [RefSeq, PubMed]; Findings identify SCT and SCTR as novel elements of the ANGII osmoregulatory pathway in maintaining fluid balance in the body., [RefSeq, PubMed]; G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:20927047, PubMed:24273196, PubMed:30449620). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway (PubMed:30449620). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (PubMed:30449620). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (PubMed:30449620). Also able to stimulate lipolysis in white adipocytes (PubMed:24273196). Also plays an important role in cellular osmoregulation by regulating renal water reabsorption (PubMed:17283064). Also plays a role in the central nervous system: required for synaptic plasticity (PubMed:17008357)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading., [RefSeq, PubMed]; Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration., [RefSeq, PubMed]; Secretin receptor-deficient mice exhibit robust food anticipatory activity., [RefSeq, PubMed]; Stable knockdown of SR expression reduced basal cholangiocyte proliferation. SR is an important trophic regulator sustaining biliary growth., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q80T66", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding;GO:0015055 secretin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0032098 regulation of appetite;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5FWI2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDT1-1", "uniprot_id": [ { "id": "SC5A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDT1", "type": "external" } ], "mass": 75065.0, "length": 685, "protein_name": "Sodium/glucose cotransporter 4", "gene_name": "Slc5a9", "organism": "Mouse", "refseq_name": "sodium/glucose cotransporter 4", "refseq_ac": [ { "id": "NP_663526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663526", "type": "external" } ], "gene_names_uniprotkb": "Slc5a9; Sglt4", "gene_names_refseq": "SGLT4; Slc5a9", "protein_names_uniprotkb": "Sodium/glucose cotransporter 4; Na(+)/glucose cotransporter 4; Solute carrier family 5 member 9; mSGLT4", "protein_names_refseq": "Na(+)/glucose cotransporter 4; mSGLT4; sodium/glucose cotransporter 4; solute carrier family 5 member 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:230612); (R-MMU-189200)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15607332;21750661;34428180;35820727", "class_list": "", "function": "Electrogenic Na(+)-coupled sugar symporter that may play a primary role in D-mannose and possibly D-fructose and D-glucose transport at the plasma membrane. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2., [UniProtKB, UniProtKB]; SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc). Erratum:[Life Sci. 2010 Oct 9;87(15-16):514], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGU9;Q8BZW1", "ec_number_list": [], "go_molecular_function": "GO:0005402 carbohydrate:monoatomic cation symporter activity;GO:0015149 hexose transmembrane transporter activity;GO:0015370 solute:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VDT1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35114-1", "uniprot_id": [ { "id": "SCRB2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35114", "type": "external" } ], "mass": 54044.0, "length": 478, "protein_name": "Lysosome membrane protein 2", "gene_name": "Scarb2", "organism": "Mouse", "refseq_name": "lysosome membrane protein 2", "refseq_ac": [ { "id": "NP_031670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031670", "type": "external" } ], "gene_names_uniprotkb": "Scarb2", "gene_names_refseq": "9330185J12Rik; Cd36l2; LGP85; LIMP II; LIMP-2; MLGP85; Scarb2", "protein_names_uniprotkb": "Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85; LIMP II; Lysosome membrane protein II; Scavenger receptor class B member 2", "protein_names_refseq": "85 kDa lysosomal membrane sialoglycoprotein; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2; lysosome membrane protein 2; lysosome membrane protein II", "tax_id": 10090, "disease": "progressive myoclonus epilepsy 4 (Disease Ontology:DOID:0111444); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (mmu:12492); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 29, "publication_id_list": "10.1101/2023.09.13.557529;11801660;12055214;12055215;12356916;12376530;16075062;18022370;19349973;20173027;22872234;24162852;25428506;26740625;27802388;30084848;30779550;30899004;31219806;31599954;32152506;34428180;35820727;35867561;35955761;37507081;37828378;40885482;9399579", "class_list": "", "function": "Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting., [UniProtKB, PubMed, PubMed]; CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo., [RefSeq, PubMed]; CD36 is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells., [RefSeq, PubMed]; Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice., [RefSeq, PubMed]; Overexpression of LGP85 causes an enlargement of early endosomes and late endosomes/lysosomes. LGP85 may participate in reorganizing the endosomal/lysosomal compartments., [RefSeq, PubMed]; SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence, [RefSeq, PubMed]; The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a CD36-like type III transmembrane glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 2, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q3UNF8", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0030666 endocytic vesicle membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0006914 autophagy;GO:0006898 receptor-mediated endocytosis;GO:0006622 protein targeting to lysosome;GO:0015917 aminophospholipid transport", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "O35114-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88576-1", "uniprot_id": [ { "id": "S6A18_MOUSE", "url": "https://www.uniprot.org/uniprot/O88576", "type": "external" } ], "mass": 69229.0, "length": 615, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT3", "gene_name": "Slc6a18", "organism": "Mouse", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT3 isoform 1", "refseq_ac": [ { "id": "NP_001035782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035782", "type": "external" } ], "gene_names_uniprotkb": "Slc6a18; B0at3; Xt2; Xtrp2", "gene_names_refseq": "B0AT3; D630001K16Rik; Slc6a18; Xt2; Xtrp2", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT3; Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; System B(0) neutral amino acid transporter AT3", "protein_names_refseq": "X transporter protein 2; b(0)AT3; sodium and chloride dependent transporter Xtrp2; sodium- and chloride-dependent transporter XTRP2; sodium-dependent neutral amino acid transporter B(0)AT3 isoform 1; sodium-dependent neutral amino acid transporter B(0)AT3; solute carrier family 6 member 18; system B 0 neutral amino acid transporter AT3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22598)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15121838;19478081;20377526;20485683;21750661;26240152;34428180;9932288", "class_list": "", "function": "Analysis of the interaction of amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin, [RefSeq, PubMed]; Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption (PubMed:19478081, PubMed:20377526, PubMed:26240152). Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids (PubMed:19478081, PubMed:20377526, PubMed:26240152). Required CLTRN for cell surface expression and for its amino acid transporter activity (PubMed:20377526, PubMed:26240152). The transport mechanism is pH-independent (PubMed:19478081)., [UniProtKB, PubMed, PubMed, PubMed]; The XT2 orphan transporter is involved in glycine reabsorption, and the absence of this transporter is sufficient to cause hypertension., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88577;O88578;O88579;O88580;O88581;Q91XG6", "ec_number_list": [], "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0140931 neutral L-amino acid:sodium:chloride symporter activity;GO:0046872 metal ion binding;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0003333 amino acid transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88576-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5K1-1", "uniprot_id": [ { "id": "SBK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C5K1", "type": "external" } ], "mass": 39699.0, "length": 362, "protein_name": "Serine/threonine-protein kinase SBK2", "gene_name": "Sbk2", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase SBK2", "refseq_ac": [ { "id": "NP_001139801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139801", "type": "external" } ], "gene_names_uniprotkb": "Sbk2; Sgk069", "gene_names_refseq": "Gm1079; Sbk2; Sgk069", "protein_names_uniprotkb": "Serine/threonine-protein kinase SBK2; 2.7.11.1; SH3 domain-binding kinase family member 2; SgK069; Sugen kinase 69", "protein_names_refseq": "SH3 domain-binding kinase family member 2; serine/threonine-protein kinase SBK2; sugen kinase 69", "tax_id": 10090, "disease": "", "pathway": " (mmu:381836)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QLZ2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C5K1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20826-1", "uniprot_id": [ { "id": "SCF_MOUSE", "url": "https://www.uniprot.org/uniprot/P20826", "type": "external" } ], "mass": 30645.0, "length": 273, "protein_name": "Kit ligand", "gene_name": "Kitlg; Kitl", "organism": "Mouse", "refseq_name": "kit ligand isoform 2 precursor", "refseq_ac": [ { "id": "NP_001334085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334085", "type": "external" } ], "gene_names_uniprotkb": "Kitlg; Kitl; Kitl; Mgf; Slf; Sl", "gene_names_refseq": "Clo; Con; Gb; Kitlg; Kitl; Mgf; SCF; SF; SLF; Sl; blz; contrasted", "protein_names_uniprotkb": "Kit ligand; Hematopoietic growth factor KL; MGF; Mast cell growth factor; SCF; Steel factor; Stem cell factor; c-Kit ligand", "protein_names_refseq": "C-kit ligand; Steel factor; cloud gray; grizzle-belly; hematopoietic growth factor KL; kit ligand isoform 2 precursor; mast cell growth factor; stem cell factor", "tax_id": 10090, "disease": "autosomal dominant nonsyndromic deafness 69 (Disease Ontology:DOID:0110590); familial progressive hyperpigmentation with or without hypopigmentation (Disease Ontology:DOID:0111373); pigmentation disease (Disease Ontology:DOID:10123); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:17311); (R-MMU-1257604); (R-MMU-1433557); (R-MMU-1433559); (R-MMU-5673001); (R-MMU-6811558); (R-MMU-9856649)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "1378327;1383087;1698553;1698554;1698556;1698557;1698558;1705866;17255936;21750661;25428506;26522471;30084848;34428180;8849898;8875893;9360640", "class_list": "", "function": "Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97332;Q3TNJ7;Q62524;Q64222;Q921N5", "ec_number_list": [], "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0008584 male gonad development;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P20826-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31650-1", "uniprot_id": [ { "id": "S6A11_MOUSE", "url": "https://www.uniprot.org/uniprot/P31650", "type": "external" } ], "mass": 69961.0, "length": 627, "protein_name": "Sodium- and chloride-dependent GABA transporter 3", "gene_name": "Slc6a11", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent GABA transporter 3", "refseq_ac": [ { "id": "NP_766478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766478", "type": "external" } ], "gene_names_uniprotkb": "Slc6a11; Gabt3; Gabt4; Gat-4; Gat3; Gat4", "gene_names_refseq": "D930045G19Rik; E130202I16Rik; GAT4; Gabt4; Gat3; Slc6a11", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 3; GAT-3; GAT-4; Sodium- and chloride-dependent GABA transporter 4; Solute carrier family 6 member 11", "protein_names_refseq": "GAT-3; GAT-4; gamma-aminobutyric acid (GABA-A) transporter 4; sodium- and chloride-dependent GABA transporter 3; sodium- and chloride-dependent GABA transporter 4; solute carrier family 6 member 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:243616); (R-MMU-442660); (R-MMU-71288); (R-MMU-888593)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "25428506;30270321;33009395;33300544;38697303;38878858;8420981", "class_list": "", "function": "GABA transporter mGat4 is involved in multiple neural functions in mice., [RefSeq, PubMed]; GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:30270321, PubMed:8420981). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (PubMed:30270321, PubMed:8420981)., [UniProtKB, PubMed, PubMed]; Up-regulating GABA transporter-3 in the zona incerta prevents surgery-induced memory impairment in mice., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWA7", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0016597 amino acid binding;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:0001504 neurotransmitter uptake;GO:0015718 monocarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31650-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58467-1", "uniprot_id": [ { "id": "SETD4_MOUSE", "url": "https://www.uniprot.org/uniprot/P58467", "type": "external" } ], "mass": 49810.0, "length": 439, "protein_name": "SET domain-containing protein 4", "gene_name": "Setd4", "organism": "Mouse", "refseq_name": "SET domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_663457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663457", "type": "external" } ], "gene_names_uniprotkb": "Setd4; ORF21", "gene_names_refseq": "C21orf18; ORF21; Setd4", "protein_names_uniprotkb": "SET domain-containing protein 4; 2.1.1.-; 2.1.1.364", "protein_names_refseq": "SET domain-containing protein 4 isoform 1; SET domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:224440)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11707072;21750661;31376731;31794893;32259569;33506343;36027907", "class_list": "", "function": "Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31376731, PubMed:31794893, PubMed:33506343). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF (PubMed:31376731). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (By similarity) (PubMed:33506343). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (PubMed:36027907). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (PubMed:33506343). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX-mediated apoptosis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3X9W6", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140941 histone H4K20me methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006954 inflammatory response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032755 positive regulation of interleukin-6 production;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P58467-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60897-1", "uniprot_id": [ { "id": "SEM1_MOUSE", "url": "https://www.uniprot.org/uniprot/P60897", "type": "external" } ], "mass": 8278.0, "length": 70, "protein_name": "26S proteasome complex subunit SEM1", "gene_name": "Sem1", "organism": "Mouse", "refseq_name": "26S proteasome complex subunit SEM1", "refseq_ac": [ { "id": "NP_033195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033195", "type": "external" } ], "gene_names_uniprotkb": "Sem1; Dss1; Shfdg1; Shfm1", "gene_names_refseq": "DSS1; Sem1; Shfdg1; Shfg; Shfm1", "protein_names_uniprotkb": "26S proteasome complex subunit SEM1; 26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1 homolog; Split hand/foot deleted protein 1 homolog; Split hand/foot malformation type 1 protein homolog", "protein_names_refseq": "26S proteasome complex subunit DSS1; 26S proteasome complex subunit SEM1; deleted in split hand/split foot protein 1 homolog; split hand/foot deleted gene 1; split hand/foot deleted protein 1 homolog; split hand/foot malformation (ectrodactyly) type 1; split hand/foot malformation type 1 protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:20422)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25428506;8733122", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q13437;Q61067", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0032991 protein-containing complex;GO:0032039 integrator complex;GO:0070390 transcription export complex 2", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000724 double-strand break repair via homologous recombination;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60897-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63300-1", "uniprot_id": [ { "id": "SELW_MOUSE", "url": "https://www.uniprot.org/uniprot/P63300", "type": "external" } ], "mass": 9687.0, "length": 88, "protein_name": "Selenoprotein W", "gene_name": "Selenow", "organism": "Mouse", "refseq_name": "selenoprotein W", "refseq_ac": [ { "id": "NP_033182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033182", "type": "external" } ], "gene_names_uniprotkb": "Selenow; Selw; Sepw1", "gene_names_refseq": "Selenow; Sepw1; selW", "protein_names_uniprotkb": "Selenoprotein W; SelW", "protein_names_refseq": "selenoprotein W, muscle 1; selenoprotein W", "tax_id": 10090, "disease": "", "pathway": " (mmu:20364)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12062442;16876868;17503775;17928294;34428180;38683225;39020075;9256076", "class_list": "", "function": "Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency., [UniProtKB, PubMed, PubMed, PubMed]; Selenoprotein W engages in overactive osteoclast differentiation in multiple myeloma. Publication Status: Online-Only, [RefSeq, PubMed]; Selenoprotein W is involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress, [RefSeq, PubMed]; Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35965;P49904;Q9JIC2", "ec_number_list": [], "go_molecular_function": "GO:0016209 antioxidant activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0030218 erythrocyte differentiation;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P63300-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82349-1", "uniprot_id": [ { "id": "SGCB_MOUSE", "url": "https://www.uniprot.org/uniprot/P82349", "type": "external" } ], "mass": 34873.0, "length": 320, "protein_name": "Beta-sarcoglycan", "gene_name": "Sgcb", "organism": "Mouse", "refseq_name": "beta-sarcoglycan", "refseq_ac": [ { "id": "NP_036020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036020", "type": "external" } ], "gene_names_uniprotkb": "Sgcb", "gene_names_refseq": "43DAG; Sgcb; beta-SG", "protein_names_uniprotkb": "Beta-sarcoglycan; 43 kDa dystrophin-associated glycoprotein; 43DAG; Beta-SG", "protein_names_refseq": "43 kDa dystrophin-associated glycoprotein; beta-sarcoglycan; sarcoglycan, beta (43kD dystrophin-associated glycoprotein)", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2E (Disease Ontology:DOID:0110279); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:24051); (R-MMU-9913351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;10448073;10678176;25428506;30899004;31219806;39927985;9864373", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TEU9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0016011 dystroglycan complex", "go_biological_process": "GO:0061024 membrane organization;GO:0007517 muscle organ development;GO:0042593 glucose homeostasis;GO:0009749 response to glucose;GO:0055013 cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P82349-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97401-1", "uniprot_id": [ { "id": "SFRP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P97401", "type": "external" } ], "mass": 36011.0, "length": 323, "protein_name": "Secreted frizzled-related protein 3", "gene_name": "Frzb", "organism": "Mouse", "refseq_name": "secreted frizzled-related protein 3 precursor", "refseq_ac": [ { "id": "NP_035486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035486", "type": "external" } ], "gene_names_uniprotkb": "Frzb; Fiz; Fre; Frzb1; Sfrp3", "gene_names_refseq": "Frp; Frzb; Sfrp3; frezzled; fritz; frzb-1", "protein_names_uniprotkb": "Secreted frizzled-related protein 3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1; sFRP-3", "protein_names_refseq": "frizzled-related protein 1; secreted frizzled-related protein 3 precursor; secreted frizzled-related protein 3; secreted frizzled-related sequence protein 3", "tax_id": 10090, "disease": "lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20378)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;11452312;19188438;36174667;9096311;9118218;9178261", "class_list": "", "function": "Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice., [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09075;O09093;Q91W58", "ec_number_list": [], "go_molecular_function": "GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0048731 system development;GO:0008285 negative regulation of cell population proliferation;GO:0042472 inner ear morphogenesis;GO:0043065 positive regulation of apoptotic process;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97401-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97952-1", "uniprot_id": [ { "id": "SCN1B_MOUSE", "url": "https://www.uniprot.org/uniprot/P97952", "type": "external" } ], "mass": 24650.0, "length": 218, "protein_name": "Sodium channel regulatory subunit beta-1", "gene_name": "Scn1b", "organism": "Mouse", "refseq_name": "sodium channel regulatory subunit beta-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_035452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035452", "type": "external" } ], "gene_names_uniprotkb": "Scn1b", "gene_names_refseq": "Scn1b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-1", "protein_names_refseq": "sodium channel regulatory subunit beta-1 isoform 1 precursor; sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel, voltage-gated, type I, beta polypeptide", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 52 (Disease Ontology:DOID:0080455); Brugada syndrome 5 (Disease Ontology:DOID:0110222); generalized epilepsy with febrile seizures plus 1 (Disease Ontology:DOID:0111302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:20266)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;19710327;25428506;30899004;36257954;39120465;9013777;9721701", "class_list": "", "function": "Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b., [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). The accessory beta subunits participate in localization and functional modulation of the Nav channels (By similarity). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 8818, "biomarker_type": "", "glycan_count": 11, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0014704 intercalated disc;GO:0030315 T-tubule;GO:0033268 node of Ranvier", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0051899 membrane depolarization;GO:0086010 membrane depolarization during action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P97952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPR9-1", "uniprot_id": [ { "id": "SBSPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPR9", "type": "external" } ], "mass": 29464.0, "length": 264, "protein_name": "Somatomedin-B and thrombospondin type-1 domain-containing protein", "gene_name": "Sbspon", "organism": "Mouse", "refseq_name": "somatomedin-B and thrombospondin type-1 domain-containing protein precursor", "refseq_ac": [ { "id": "NP_001028460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028460", "type": "external" } ], "gene_names_uniprotkb": "Sbspon; Gm106; Rpesp", "gene_names_refseq": "Gm106; Rpesp; Sbspon", "protein_names_uniprotkb": "Somatomedin-B and thrombospondin type-1 domain-containing protein; RPE-spondin", "protein_names_refseq": "RPE-spondin; somatomedin-B and thrombospondin type-1 domain-containing protein precursor; somatomedin-B and thrombospondin type-1 domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:226866); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RVH7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UPR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497L8-1", "uniprot_id": [ { "id": "S22AG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q497L8", "type": "external" } ], "mass": 73933.0, "length": 649, "protein_name": "Solute carrier family 22 member 16", "gene_name": "Slc22a16", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 16", "refseq_ac": [ { "id": "NP_081848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081848", "type": "external" } ], "gene_names_uniprotkb": "Slc22a16", "gene_names_refseq": "4921504E14Rik; CT2; FLIPT2; OCT6; OKB1; Slc22a16", "protein_names_uniprotkb": "Solute carrier family 22 member 16; CT2; Carnitine transporter 2", "protein_names_refseq": "carnitine transporter 2; solute carrier family 22 member 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:70840); (R-MMU-549127)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Facilitative organic cation transporter that mediates the transport of carnitine as well as the polyamine spermidine. Mediates the partially Na(+)-dependent bidirectional transport of carnitine. May mediate L-carnitine secretion from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3LVC1", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005275 amine transmembrane transporter activity;GO:0015226 carnitine transmembrane transporter activity;GO:0015606 spermidine transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046717 acid secretion;GO:0015695 organic cation transport;GO:0006811 monoatomic ion transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497L8-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4LFA9-1", "uniprot_id": [ { "id": "SEM3G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4LFA9", "type": "external" } ], "mass": 86695.0, "length": 780, "protein_name": "Semaphorin-3G", "gene_name": "Sema3g", "organism": "Mouse", "refseq_name": "semaphorin-3G precursor", "refseq_ac": [ { "id": "NP_001020550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020550", "type": "external" } ], "gene_names_uniprotkb": "Sema3g", "gene_names_refseq": "Sema3g", "protein_names_uniprotkb": "Semaphorin-3G", "protein_names_refseq": "Semaphorin 3G; semaphorin-3G precursor; semaphorin-3G", "tax_id": 10090, "disease": "", "pathway": " (mmu:218877)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;16098142;30899004;34921404", "class_list": "", "function": "Has chemorepulsive activities for sympathetic axons. Ligand of NRP2., [UniProtKB, PubMed]; In adulthood, Sema3G is mainly expressed in the lung and kidney, and a little in the brain. We also found that Sema3G binds Neuropilin-2, but not Neuropilin-1, and induces the repulsion of sympathetic axons., [RefSeq, PubMed]; Notch1 promotes ordered revascularization through Semaphorin 3g modulation of downstream vascular patterning signalling factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3UVA7", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q4LFA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A07-1", "uniprot_id": [ { "id": "SCN2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q56A07", "type": "external" } ], "mass": 24228.0, "length": 215, "protein_name": "Sodium channel regulatory subunit beta-2", "gene_name": "Scn2b", "organism": "Mouse", "refseq_name": "sodium channel regulatory subunit beta-2 precursor", "refseq_ac": [ { "id": "NP_001014761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014761", "type": "external" } ], "gene_names_uniprotkb": "Scn2b; Gm183", "gene_names_refseq": "2810451E09Rik; Gm183; Scn2b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-2", "protein_names_refseq": "sodium channel regulatory subunit beta-2 precursor; sodium channel regulatory subunit beta-2; sodium channel subunit beta-2; sodium channel, voltage-gated, type II, beta polypeptide", "tax_id": 10090, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); otitis media (Disease Ontology:DOID:10754)", "pathway": " (mmu:72821)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15833746;31257483;32124967;38866121", "class_list": "", "function": "Beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells Erratum:[J Biol Chem. 2005 Aug 19;280(33):29988], [RefSeq, PubMed]; MicroRNA-6954-3p Downregulation Contributes to Orofacial Neuropathic Pain in Mice Via Targeting Voltage-Gated Sodium Channel beta2 Subunit Protein., [RefSeq, PubMed]; MicroRNA449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice., [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8., [UniProtKB, UniProtKB]; The present findings suggested that knockdown of Navb2 reversed the APP/PS1 mutationinduced deficiency in amyloid b degradation by regulating NEP., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0017080 sodium channel regulator activity;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030315 T-tubule;GO:0033268 node of Ranvier;GO:0043194 axon initial segment;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0007399 nervous system development;GO:0086010 membrane depolarization during action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060048 cardiac muscle contraction;GO:0061337 cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q56A07-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4D3-1", "uniprot_id": [ { "id": "S36A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4D3", "type": "external" } ], "mass": 52466.0, "length": 475, "protein_name": "Proton-coupled amino acid transporter 1", "gene_name": "Slc36a1", "organism": "Mouse", "refseq_name": "proton-coupled amino acid transporter 1", "refseq_ac": [ { "id": "NP_694779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694779", "type": "external" } ], "gene_names_uniprotkb": "Slc36a1; Pat1", "gene_names_refseq": "5830411H19Rik; Pat1; Slc36a1", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 1; Proton/amino acid transporter 1; Solute carrier family 36 member 1", "protein_names_refseq": "proton-coupled amino acid transporter 1; proton/amino acid transporter 1; solute carrier family 36 member 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215335); (R-MMU-352230); (R-MMU-428559)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11959859;15058382;15504109;18496516;21750661;24425764;27802388;34572527", "class_list": "", "function": "Data suggest that a high-fat diet induces expression of two amino acid transporters (Slc36a1, Slc6a20a) in intestinal mucosa pointing to a specific and adaptive absorption of some amino acids in high-fat diet-induced obesity and glucose intolerance., [RefSeq, PubMed]; Detailed analysis of the transport mode of the murine PAT1 in oocytes; PAT1 is an electrogenic H+-coupled amino acid symporter with the capability for bidirectional amino acid transport, [RefSeq, PubMed]; Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:11959859). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity). May play a role in specifying sites for exocytosis in neurons (By similarity)., [UniProtKB, UniProtKB, PubMed]; Insights into the Interaction of Lysosomal Amino Acid Transporters SLC38A9 and SLC36A1 Involved in mTORC1 Signaling in C2C12 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The essential role of chloride and fructose absorbing Slc36a1 is reported., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q811N9", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0015824 proline transport;GO:0032328 alanine transport;GO:0035524 proline transmembrane transport;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K4D3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60519-1", "uniprot_id": [ { "id": "SEM5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60519", "type": "external" } ], "mass": 120327.0, "length": 1093, "protein_name": "Semaphorin-5B", "gene_name": "Sema5b", "organism": "Mouse", "refseq_name": "semaphorin-5B precursor", "refseq_ac": [ { "id": "NP_038689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038689", "type": "external" } ], "gene_names_uniprotkb": "Sema5b; Kiaa1445; SemG; Semag", "gene_names_refseq": "SemG; Sema5b; Semag; mKIAA1445", "protein_names_uniprotkb": "Semaphorin-5B; Sema G; Semaphorin-G", "protein_names_refseq": "sema G; semaphorin-5B precursor; semaphorin-5B; semaphorin-G", "tax_id": 10090, "disease": "", "pathway": " (mmu:20357); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25428506;34428180;8817451", "class_list": "", "function": "May act as a positive axonal guidance cue., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "B1B1A9;Q6ZPQ8;Q7TT33;Q8BVE5", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q60519-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60850-1", "uniprot_id": [ { "id": "S23A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60850", "type": "external" } ], "mass": 64878.0, "length": 611, "protein_name": "Solute carrier family 23 member 3", "gene_name": "Slc23a3", "organism": "Mouse", "refseq_name": "solute carrier family 23 member 3", "refseq_ac": [ { "id": "NP_919314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919314", "type": "external" } ], "gene_names_uniprotkb": "Slc23a3; Svct3; Yspl1", "gene_names_refseq": "SVCT3; Slc23a3; Yspl1", "protein_names_uniprotkb": "Solute carrier family 23 member 3; Na(+)/L-ascorbic acid transporter 3; Sodium-dependent vitamin C transporter 3; YSPL-1; Yolk sac permease-like molecule 1", "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 3; YSPL-1; sodium-dependent vitamin C transporter 3; solute carrier family 23 member 3; yolk sac permease-like molecule 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22626)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;7588067", "class_list": "", "function": "Acts as a sodium-dependent hypoxanthine transporter. May show xanthine-hypoxanthine exchange activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149H3;Q4VBX5;Q60851;Q60852;Q60853;Q78E82;Q78E83;Q78E84", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0035344 hypoxanthine transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q60850-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62179-1", "uniprot_id": [ { "id": "SEM4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62179", "type": "external" } ], "mass": 91392.0, "length": 823, "protein_name": "Semaphorin-4B", "gene_name": "Sema4b", "organism": "Mouse", "refseq_name": "semaphorin-4B precursor", "refseq_ac": [ { "id": "NP_038687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038687", "type": "external" } ], "gene_names_uniprotkb": "Sema4b; Kiaa1745; SemC; Semac", "gene_names_refseq": "SemC; Sema4b; Semac; mKIAA1745; sema C", "protein_names_uniprotkb": "Semaphorin-4B; Sema C; Semaphorin-C", "protein_names_refseq": "semaphorin-4B precursor; semaphorin-4B; semaphorin-C", "tax_id": 10090, "disease": "", "pathway": " (mmu:20352)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10318831;16075062;19144319;19349973;21183079;26495903;28011936;30899004;32152506;37121509;38781210;7748561", "class_list": "", "function": "Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia., [RefSeq, PubMed]; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons., [UniProtKB]; Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q4PKI6;Q69ZB7", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q62179-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62217-1", "uniprot_id": [ { "id": "SEM5A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62217", "type": "external" } ], "mass": 120826.0, "length": 1077, "protein_name": "Semaphorin-5A", "gene_name": "Sema5a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sema5a; SemF; Semaf", "gene_names_refseq": "", "protein_names_uniprotkb": "Semaphorin-5A; Sema F; Semaphorin-F", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-416700); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15743826;19850054;21835343;8817451", "class_list": "", "function": "Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0045499 chemorepellent activity;GO:0045545 syndecan binding;GO:0035373 chondroitin sulfate proteoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0021536 diencephalon development;GO:1990256 signal clustering;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62217-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64124-1", "uniprot_id": [ { "id": "SCX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64124", "type": "external" } ], "mass": 22239.0, "length": 207, "protein_name": "Basic helix-loop-helix transcription factor scleraxis", "gene_name": "Scx", "organism": "Mouse", "refseq_name": "basic helix-loop-helix transcription factor scleraxis", "refseq_ac": [ { "id": "NP_942588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942588", "type": "external" } ], "gene_names_uniprotkb": "Scx", "gene_names_refseq": "Bhlha41; Scl; Scx", "protein_names_uniprotkb": "Basic helix-loop-helix transcription factor scleraxis", "protein_names_refseq": "basic helix-loop-helix transcription factor scleraxis; scleraxis", "tax_id": 10090, "disease": "", "pathway": " (mmu:20289)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10477299;18802027;7743923", "class_list": "", "function": "Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages., [UniProtKB]; Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo., [RefSeq, PubMed]; This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction. [provided by RefSeq, Feb 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64124-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6T707-1", "uniprot_id": [ { "id": "SCD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6T707", "type": "external" } ], "mass": 41042.0, "length": 353, "protein_name": "Stearoyl-CoA desaturase 4", "gene_name": "Scd4", "organism": "Mouse", "refseq_name": "stearoyl-CoA desaturase 4", "refseq_ac": [ { "id": "NP_899039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899039", "type": "external" } ], "gene_names_uniprotkb": "Scd4", "gene_names_refseq": "ACOD4; Scd4", "protein_names_uniprotkb": "Stearoyl-CoA desaturase 4; 1.14.19.1; Acyl-CoA desaturase 4; Delta(9)-desaturase 4; Delta-9 desaturase 4; Fatty acid desaturase 4", "protein_names_refseq": "acyl-CoA desaturase 4; delta(9)-desaturase 4; fatty acid desaturase 4; stearoyl-CoA desaturase 4", "tax_id": 10090, "disease": "restrictive cardiomyopathy (Disease Ontology:DOID:397)", "pathway": " (mmu:329065)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12815040;16118274;16443825;34428180;36142371", "class_list": "glycogene", "function": "Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0., [RefSeq, PubMed]; SCD4 demonstrates tissue-specific regulation by leptin and dietary factors., [RefSeq, PubMed]; Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy Metabolism in Ischemic Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:12815040, PubMed:16443825). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 23, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIY5", "ec_number_list": [ { "id": "1.14.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1", "type": "external" }, { "id": "1.14.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004768 stearoyl-CoA 9-desaturase activity;GO:0016491 oxidoreductase activity;GO:0032896 palmitoyl-CoA 9-desaturase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0006633 fatty acid biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:1903966 monounsaturated fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6T707-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M729-1", "uniprot_id": [ { "id": "SCN4B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M729", "type": "external" } ], "mass": 25192.0, "length": 228, "protein_name": "Sodium channel regulatory subunit beta-4", "gene_name": "Scn4b", "organism": "Mouse", "refseq_name": "sodium channel regulatory subunit beta-4 precursor", "refseq_ac": [ { "id": "NP_001013408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013408", "type": "external" } ], "gene_names_uniprotkb": "Scn4b; Gm1471", "gene_names_refseq": "Gm1471; Scn4b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-4", "protein_names_refseq": "sodium channel accessory subunit; sodium channel regulatory subunit beta-4 precursor; sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit", "tax_id": 10090, "disease": "long QT syndrome 10 (Disease Ontology:DOID:0110651)", "pathway": " (mmu:399548)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12930796;16805843;22645316;30899004;35076394", "class_list": "", "function": "Down-regulation of Scn4b may lead to abnormalities of sodium channel and neurite degeneration in the striatum of Huntington's disease transgenic mice, [RefSeq, PubMed]; Intrinsic mechanisms in the gating of resurgent Na(+) currents. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1. Modulates the activity of SCN2A/Nav1.2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060048 cardiac muscle contraction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0061337 cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q7M729-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UJ1-1", "uniprot_id": [ { "id": "S22AK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UJ1", "type": "external" } ], "mass": 60944.0, "length": 556, "protein_name": "Solute carrier family 22 member 20", "gene_name": "Slc22a20", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 20", "refseq_ac": [ { "id": "NP_941052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941052", "type": "external" } ], "gene_names_uniprotkb": "Slc22a20; Gm963; Oat6", "gene_names_refseq": "Gm963; OAT1-L; Slc22a20; mOAT6", "protein_names_uniprotkb": "Solute carrier family 22 member 20; Organic anion transporter 6", "protein_names_refseq": "OAT1-like organic anion transporter; SLC22 organic anion transporter; organic anion transporter 6; solute carrier family 22 member 20", "tax_id": 10090, "disease": "", "pathway": " (mmu:381203)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15369770;16478971;17094945;17553798;18174163;19737926;20519554;25428506", "class_list": "", "function": "Despite sharing close overall sequence homology, Oat1, Oat3, and Oat6 have signficantly different binding pockets, [RefSeq, PubMed]; Expression in Sertoli cells suggests Oat6 may be an important determinant of blood-testis barrier function, [RefSeq, PubMed]; Oat1, Oat3, and Oat6 function largely in organic anion transport but also bind and transport organic cations., [RefSeq, PubMed]; Oat6 might play a direct or indirect role in olfaction, such as modulation of the availability of odorant organic anions at the mucosal surface., [RefSeq, PubMed]; Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter., [UniProtKB, PubMed, PubMed]; The substrate binding preferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the more broadly expressed transporter, Oat1, [RefSeq, PubMed]; These data demonstrate for the first time that the novel murine gene Oat6 (Slc22a20) encodes a functional organic anion transporter and mOat6 is indeed the newest member of the OAT gene family., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5JBT1", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80UJ1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGK5-1", "uniprot_id": [ { "id": "S35F1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGK5", "type": "external" } ], "mass": 45304.0, "length": 408, "protein_name": "Solute carrier family 35 member F1", "gene_name": "Slc35f1", "organism": "Mouse", "refseq_name": "solute carrier family 35 member F1", "refseq_ac": [ { "id": "NP_848790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848790", "type": "external" } ], "gene_names_uniprotkb": "Slc35f1", "gene_names_refseq": "Duf6; E130016L02; Slc35f1", "protein_names_uniprotkb": "Solute carrier family 35 member F1", "protein_names_refseq": "DUF6 containing protein; solute carrier family 35 member F1", "tax_id": 10090, "disease": "", "pathway": " (mmu:215085)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "25428506;30084848;30868340;36951990", "class_list": "", "function": "Morphological and behavioral analysis of Slc35f1-deficient mice revealed no neurodevelopmental phenotype., [RefSeq, PubMed]; Putative solute transporter., [UniProtKB]; The authors demonstrate that Slc35f1 is highly expressed in the adult mouse brain in a variety of different brain structures, including the cortex, hippocampus, amygdala, thalamus, basal ganglia, and hypothalamus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TNT3;Q8BKD4;Q8BVI2;Q8BX52", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0030672 synaptic vesicle membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BGK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU14-1", "uniprot_id": [ { "id": "SEC62_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU14", "type": "external" } ], "mass": 45581.0, "length": 398, "protein_name": "Translocation protein SEC62", "gene_name": "Sec62", "organism": "Mouse", "refseq_name": "translocation protein SEC62 isoform 2", "refseq_ac": [ { "id": "NP_081292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081292", "type": "external" } ], "gene_names_uniprotkb": "Sec62; Tloc1", "gene_names_refseq": "3100002M17Rik; Dtrp1; HTP1; Sec62; Tloc1", "protein_names_uniprotkb": "Translocation protein SEC62; TP-1; Translocation protein 1", "protein_names_refseq": "SEC62 homolog; TP-1; translocation protein 1; translocation protein SEC62 isoform 2; translocation protein SEC62", "tax_id": 10090, "disease": "", "pathway": " (mmu:69276)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17208939;17242355;18630941;19144319;21183079;22375059;25605945;26495903;26634806;27749824;34428180", "class_list": "", "function": "Identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis Erratum:[Nat Cell Biol. 2016 Dec 23;19(1):76. doi: 10.1038/ncb3451. PMID: 28008182], [RefSeq, PubMed]; Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen., [UniProtKB, UniProtKB]; The Sec62 protein plays a role in post-translational transport of presecretory proteins into endoplasmic reticulum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NX81", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0031204 post-translational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8BU14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYF6-1", "uniprot_id": [ { "id": "SC5A8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYF6", "type": "external" } ], "mass": 66766.0, "length": 611, "protein_name": "Sodium-coupled monocarboxylate transporter 1", "gene_name": "Slc5a8", "organism": "Mouse", "refseq_name": "sodium-coupled monocarboxylate transporter 1", "refseq_ac": [ { "id": "NP_663398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663398", "type": "external" } ], "gene_names_uniprotkb": "Slc5a8; Smct1; Smct", "gene_names_refseq": "Ait; SMCT; Slc5a8", "protein_names_uniprotkb": "Sodium-coupled monocarboxylate transporter 1; Electrogenic sodium monocarboxylate cotransporter; Solute carrier family 5 member 8", "protein_names_refseq": "electrogenic sodium monocarboxylate cotransporter; sodium-coupled monocarboxylate transporter 1; solute carrier family 5 member 8", "tax_id": 10090, "disease": "vitamin metabolic disorder (Disease Ontology:DOID:0050718)", "pathway": " (mmu:216225); (R-MMU-196807); (R-MMU-428643); (R-MMU-9958790)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "15322102;15651982;15867356;16295698;16805814;16873376;17099289;17245649;20211600;30604288;32014250;32717355;34428180;35012534;38650461", "class_list": "", "function": "Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:15322102, PubMed:15651982, PubMed:20211600). Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (By similarity). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity). Part of D-serine transport systems. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Data describe the cellular localization of Slc5a8 in the murine gastrointestinal tract and kidney by in situ hybridization and immunohistochemistry., [RefSeq, PubMed]; Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy., [RefSeq, PubMed]; SMCT functions not only as a Na+-coupled transporter for short-chain fatty acids and lactate but also as a Na+-coupled transporter for the water-soluble vitamin nicotinic acid., [RefSeq, PubMed]; Slc5a8 and slc5a12 in kidney in c/ebpdelta-/- mice have a role in the renal handling of lactate and urate, [RefSeq, PubMed]; Slc5a8 is expressed abundantly in the kidney and plays a role in the active reabsorption of lactate, [RefSeq, PubMed]; The shared epigenetic inactivation of mSLC5A8 in mouse gliomas indicates an additional degree of commonality in the origin and/or pathway to tumorigenesis between primary human tumors and these mouse models of gliomas., [RefSeq, PubMed]; Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VD01", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0090416 nicotinate transmembrane transporter activity;GO:0005343 organic acid:sodium symporter activity;GO:0015636 short-chain fatty acid transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity;GO:0015552 propionate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0000811 GINS complex", "go_biological_process": "GO:0006915 apoptotic process;GO:0006821 chloride transport;GO:0015705 iodide transport;GO:0006814 sodium ion transport;GO:2001142 nicotinate transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BYF6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C267-1", "uniprot_id": [ { "id": "SETB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C267", "type": "external" } ], "mass": 80636.0, "length": 713, "protein_name": "Histone-lysine N-methyltransferase SETDB2", "gene_name": "Setdb2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Setdb2; Gm293", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETDB2; 2.1.1.366; SET domain bifurcated 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-3214841)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0010629 negative regulation of gene expression;GO:0051301 cell division;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C267-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C650-1", "uniprot_id": [ { "id": "SEP10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C650", "type": "external" } ], "mass": 52422.0, "length": 452, "protein_name": "Septin-10", "gene_name": "Septin10", "organism": "Mouse", "refseq_name": "septin-10 isoform 1", "refseq_ac": [ { "id": "NP_001020081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020081", "type": "external" } ], "gene_names_uniprotkb": "Septin10; Sept10", "gene_names_refseq": "4921515A04Rik; 9430099J10Rik; Sept10; Septin10", "protein_names_uniprotkb": "Septin-10", "protein_names_refseq": "septin-10 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:103080)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;21183079;21750661;25153642;28135057;28528544;31219806;34203471;34428180;35700329;36210013", "class_list": "", "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSA5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0015629 actin cytoskeleton;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8C650-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CD26-1", "uniprot_id": [ { "id": "S35E1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CD26", "type": "external" } ], "mass": 44325.0, "length": 409, "protein_name": "Solute carrier family 35 member E1", "gene_name": "Slc35e1", "organism": "Mouse", "refseq_name": "solute carrier family 35 member E1", "refseq_ac": [ { "id": "NP_808434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808434", "type": "external" } ], "gene_names_uniprotkb": "Slc35e1", "gene_names_refseq": "6030458H05; Slc35e1", "protein_names_uniprotkb": "Solute carrier family 35 member E1", "protein_names_refseq": "solute carrier family 35 member E1", "tax_id": 10090, "disease": "", "pathway": " (mmu:270066)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31219806;34428180;37296095", "class_list": "", "function": "Putative transporter., [UniProtKB]; SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CD26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0Y8-1", "uniprot_id": [ { "id": "S2542_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0Y8", "type": "external" } ], "mass": 35241.0, "length": 318, "protein_name": "Mitochondrial coenzyme A transporter SLC25A42", "gene_name": "Slc25a42", "organism": "Mouse", "refseq_name": "mitochondrial coenzyme A transporter SLC25A42", "refseq_ac": [ { "id": "NP_001007571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007571", "type": "external" } ], "gene_names_uniprotkb": "Slc25a42", "gene_names_refseq": "2900084M01Rik; Slc25a42", "protein_names_uniprotkb": "Mitochondrial coenzyme A transporter SLC25A42; Solute carrier family 25 member 42", "protein_names_refseq": "mitochondrial coenzyme A transporter SLC25A42", "tax_id": 10090, "disease": "", "pathway": " (mmu:73095); (R-MMU-199220)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "30084848;34428180;37507081", "class_list": "", "function": "Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043262 ADP phosphatase activity;GO:0015291 secondary active transmembrane transporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015937 coenzyme A biosynthetic process;GO:0035349 coenzyme A transmembrane transport;GO:0080121 AMP transport;GO:0015867 ATP transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8R0Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD00-1", "uniprot_id": [ { "id": "SGMR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD00", "type": "external" } ], "mass": 20811.0, "length": 176, "protein_name": "Sigma intracellular receptor 2", "gene_name": "Tmem97", "organism": "Mouse", "refseq_name": "sigma intracellular receptor 2", "refseq_ac": [ { "id": "NP_598467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598467", "type": "external" } ], "gene_names_uniprotkb": "Tmem97; S2r", "gene_names_refseq": "1810014L12Rik; D11Bhm182e; Tmem97", "protein_names_uniprotkb": "Sigma intracellular receptor 2; Sigma-2 receptor; Sigma2 receptor; Transmembrane protein 97", "protein_names_refseq": "sigma intracellular receptor 2; sigma-2 receptor; sigma2 receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69071)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "28644012;32152506;34428180;34799735;36210013;38290642;38866499", "class_list": "", "function": "Loss of Sigma-2 Receptor/TMEM97 Is Associated with Neuropathic Injury-Induced Depression-Like Behaviors in Female Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the maintenance of cellular homeostasis. Forms a ternary complex with PGRMC1 and LDLR at the plasma membrane, promoting LDLR-mediated internalization of LDL cholesterol. Reduces the availability of the lysosomal sterol transporter NPC1, likely through direct interaction, thereby regulating lipid transport, including cholesterol and LBPA, outside of late endosome/lysosome (By similarity). Binds the regio- and stereoselective oxysterol 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735). Ligand binding enhances association with NPC1 and modulates TMEM97-containing protein complexes involving PGRMC1 and TSPO, consistent with a role in cholesterol homeostasis (By similarity). Also able to bind cholesterol (By similarity). Interacts with the salivary peptide histatin 1 (Hst 1/HTN1) at the ER membrane, which is critical for increasing mitochondria-ER contacts and stimulating Hst 1 wound healing properties. May alter the activity of some cytochrome P450 proteins. Although sharing homology with sterol isomerases through the EXPERA domain, lacks sterol isomerase activity; instead, may function as a sterol or oxysterol sensor (By similarity). Acts as an ER quality control factor by promoting proteolytic degradation of nonproductive and extramitochondrial precursor proteins in the ER membrane, thereby removing them from the ER surface (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Study generated a series of sigma1R and sigma2R/Tmem97 agonists and antagonists and tested them for efficacy in the mouse spared nerve injury model. Results show robust antineuropathic pain effects of sigma1R and sigma2R/Tmem97 ligands, demonstrate that sigma2R/Tmem97 is a novel neuropathic pain target, and identify sigma2R/Tmem97 agonist UKH-1114 as a lead molecule for further development., [RefSeq, PubMed]; Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005764 lysosome", "go_biological_process": "GO:0032383 regulation of intracellular cholesterol transport;GO:0042632 cholesterol homeostasis;GO:0090303 positive regulation of wound healing;GO:0140077 positive regulation of lipoprotein transport;GO:0032377 regulation of intracellular lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VD00-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921M3-1", "uniprot_id": [ { "id": "SF3B3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921M3", "type": "external" } ], "mass": 135550.0, "length": 1217, "protein_name": "Splicing factor 3B subunit 3", "gene_name": "Sf3b3", "organism": "Mouse", "refseq_name": "splicing factor 3B subunit 3", "refseq_ac": [ { "id": "NP_598714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598714", "type": "external" } ], "gene_names_uniprotkb": "Sf3b3; Kiaa0017", "gene_names_refseq": "1810061H24Rik; 5730409A01Rik; D8Ertd633e; RSE1; SAP130; SF3b130; Sf3b3; mKIAA0017", "protein_names_uniprotkb": "Splicing factor 3B subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SAP 130; SF3b130; Spliceosome-associated protein 130", "protein_names_refseq": "SAP 130; pre-mRNA-splicing factor SF3b 130 kDa subunit; spliceosome-associated protein 130; splicing factor 3B subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:101943); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;16479539;18250455;21913724;22872234;25428506;25428507;25605945;28315936;30084848;30779550;31219806;34203471;34428180;34887587;35820727;36210013;38096048;39627609", "class_list": "", "function": "Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity., [RefSeq, PubMed]; Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGI3;Q6ZQL0;Q8BUD9;Q8K2J8", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0042177 negative regulation of protein catabolic process;GO:0043484 regulation of RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q921M3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923D4-1", "uniprot_id": [ { "id": "SF3B5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923D4", "type": "external" } ], "mass": 10119.0, "length": 86, "protein_name": "Splicing factor 3B subunit 5", "gene_name": "Sf3b5", "organism": "Mouse", "refseq_name": "splicing factor 3B subunit 5", "refseq_ac": [ { "id": "NP_780311", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780311", "type": "external" } ], "gene_names_uniprotkb": "Sf3b5; Sf3b10", "gene_names_refseq": "10kDa; 1110005L13Rik; Sf3b10; Sf3b5", "protein_names_uniprotkb": "Splicing factor 3B subunit 5; Pre-mRNA-splicing factor SF3b 10 kDa subunit; SF3b5", "protein_names_refseq": "pre-mRNA-splicing factor SF3b 10 kDa subunit; splicing factor 3B subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:66125); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "25605945;34428180", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923D4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N0-1", "uniprot_id": [ { "id": "SFXN5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925N0", "type": "external" } ], "mass": 37329.0, "length": 342, "protein_name": "Sideroflexin-5", "gene_name": "Sfxn5", "organism": "Mouse", "refseq_name": "sideroflexin-5", "refseq_ac": [ { "id": "NP_848754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848754", "type": "external" } ], "gene_names_uniprotkb": "Sfxn5", "gene_names_refseq": "C230001H08Rik; Sfxn5", "protein_names_uniprotkb": "Sideroflexin-5", "protein_names_refseq": "sideroflexin-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:94282)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11274051;21750661;33300544;36334589", "class_list": "", "function": "Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (PubMed:36334589)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BGG3", "ec_number_list": [], "go_molecular_function": "GO:0015137 citrate transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0015746 citrate transport;GO:0120162 positive regulation of cold-induced thermogenesis;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q925N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N2-1", "uniprot_id": [ { "id": "SFXN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925N2", "type": "external" } ], "mass": 36141.0, "length": 322, "protein_name": "Sideroflexin-2", "gene_name": "Sfxn2", "organism": "Mouse", "refseq_name": "sideroflexin-2", "refseq_ac": [ { "id": "NP_444426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444426", "type": "external" } ], "gene_names_uniprotkb": "Sfxn2", "gene_names_refseq": "F630107H02Rik; Sfxn2", "protein_names_uniprotkb": "Sideroflexin-2", "protein_names_refseq": "sideroflexin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94279)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11274051;21750661;30084848;30570704;31599954;34428180;36210013;37453647", "class_list": "", "function": "Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria (By similarity). Involved in mitochondrial iron homeostasis by regulating heme biosynthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1990542 mitochondrial transmembrane transport;GO:0140300 serine import into mitochondrion;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q925N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99K24-1", "uniprot_id": [ { "id": "S39A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99K24", "type": "external" } ], "mass": 34002.0, "length": 317, "protein_name": "Zinc transporter ZIP3", "gene_name": "Slc39a3", "organism": "Mouse", "refseq_name": "zinc transporter ZIP3", "refseq_ac": [ { "id": "NP_001345827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001345827", "type": "external" } ], "gene_names_uniprotkb": "Slc39a3; Zip3", "gene_names_refseq": "Slc39a3; ZIP-3; Zip3", "protein_names_uniprotkb": "Zinc transporter ZIP3; Solute carrier family 39 member 3; ZIP-3; Zrt- and Irt-like protein 3", "protein_names_refseq": "solute carrier family 39 member 3; zinc transporter ZIP3; zrt- and Irt-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106947); (R-MMU-442380)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12401442;12727323;14525987;15054103;15634741;15964816;19458277;21036893;21209194;21750661;35169020;37359521", "class_list": "", "function": "Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons., [RefSeq, PubMed]; The expression of zinc transporter 3 (ZnT3) starts early in development, lasts throughout embryonic life, and is detected in proliferative and differentiating areas of the brain in distinct chelatable vesicular zinc pools., [RefSeq, PubMed]; Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:14525987, PubMed:15634741, PubMed:35169020). Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus (PubMed:35169020). Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen (PubMed:19458277)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; ZIP1 and ZIP3 zinc uptake transporter activity is controlled by zinc-stimulated endocytosis, [RefSeq, PubMed]; ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc, [RefSeq, PubMed]; Zip3 does not participate in the acquisition of Zn from maternal circulation for secretion into milk but, in contrast, primarily plays a role in the reuptake and cellular retention of Zn in the mammary gland from the previously secreted milk pool., [RefSeq, PubMed]; ZnT3 KO mice showed abnormality in trace fear conditioning is involved in associative fear memory and extinction, but not in innate fear. Publication Status: Online-Only, [RefSeq, PubMed]; ZnT3-immunoreactive ependymal cells possess secretory activity directed towards the central canal., [RefSeq, PubMed]; Znt-3-deficient mice lacking synaptic Zn also show less hippocampal cell damage following kainic acid injection. Zip transporters may provide selective therapeutic targets to protect these neurons from early Zn-induced neurodegeneration following injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0001701 in utero embryonic development;GO:0000902 cell morphogenesis;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99K24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M85-1", "uniprot_id": [ { "id": "SCRT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M85", "type": "external" } ], "mass": 35919.0, "length": 348, "protein_name": "Transcriptional repressor scratch 1", "gene_name": "Scrt1", "organism": "Mouse", "refseq_name": "transcriptional repressor scratch 1", "refseq_ac": [ { "id": "NP_570963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570963", "type": "external" } ], "gene_names_uniprotkb": "Scrt1", "gene_names_refseq": "Scrt1", "protein_names_uniprotkb": "Transcriptional repressor scratch 1; SCRT; Scratch 1; Scratch homolog 1 zinc finger protein; mScrt", "protein_names_refseq": "SCRT; mScrt; scratch 1; scratch homolog 1, zinc finger protein; transcriptional repressor scratch 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:170729)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11274425;11687288;16773660;18331720;20043117;23434913", "class_list": "", "function": "From perinatal to adult stages, Scratch1 remains strongly expressed in almost all brain regions, although it is not found in some ventral structures such as motor nuclei and hypothalamic regions., [RefSeq, PubMed]; SCRT1 transcripts are undetectable in nearly all of the examined tumors suggesting that SCRATCH1 plays a minor role, if any, in tumorigenesis., [RefSeq, PubMed]; Scratch proteins (1 and 2) mediate the conversion of neuroepithelial cells to migrating neurons through an epithelial-mesenchymal transition., [RefSeq, PubMed]; Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99M85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQS8-1", "uniprot_id": [ { "id": "SC61B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQS8", "type": "external" } ], "mass": 9958.0, "length": 96, "protein_name": "Protein transport protein Sec61 subunit beta", "gene_name": "Sec61b", "organism": "Mouse", "refseq_name": "protein transport protein Sec61 subunit beta", "refseq_ac": [ { "id": "NP_077133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077133", "type": "external" } ], "gene_names_uniprotkb": "Sec61b", "gene_names_refseq": "1190006C12Rik; Sec61b", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit beta", "protein_names_refseq": "Sec61 beta subunit; protein transport protein Sec61 subunit beta", "tax_id": 10090, "disease": "", "pathway": " (mmu:66212); (R-MMU-9609523)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "21750661;25428506;28375157;31219806;34428180;37453647", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0043022 ribosome binding;GO:0048408 epidermal growth factor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0036503 ERAD pathway;GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030970 retrograde protein transport, ER to cytosol;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D554-1", "uniprot_id": [ { "id": "SF3A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D554", "type": "external" } ], "mass": 58842.0, "length": 501, "protein_name": "Splicing factor 3A subunit 3", "gene_name": "Sf3a3", "organism": "Mouse", "refseq_name": "splicing factor 3A subunit 3", "refseq_ac": [ { "id": "NP_083433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083433", "type": "external" } ], "gene_names_uniprotkb": "Sf3a3; Sap61", "gene_names_refseq": "4930512K19Rik; 60kDa; Sf3a3", "protein_names_uniprotkb": "Splicing factor 3A subunit 3; SAP 61; SF3a60; Spliceosome-associated protein 61", "protein_names_refseq": "SAP 61; SF3a60; spliceosome-associated protein 61; splicing factor 3A subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:75062); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "25428506;25605945;30084848;31219806;34428180;36210013", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D554-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8F3-1", "uniprot_id": [ { "id": "S52A2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8F3", "type": "external" } ], "mass": 46864.0, "length": 450, "protein_name": "Solute carrier family 52, riboflavin transporter, member 2", "gene_name": "Slc52a2", "organism": "Mouse", "refseq_name": "solute carrier family 52, riboflavin transporter, member 2", "refseq_ac": [ { "id": "NP_083919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083919", "type": "external" } ], "gene_names_uniprotkb": "Slc52a2; Gpr172b; Rft1", "gene_names_refseq": "2010003P03Rik; D15Ertd747e; GPCR42; Gpr172b; PAR2; RFT1; Rfvt2; Slc52a2; mRFT1", "protein_names_uniprotkb": "Solute carrier family 52, riboflavin transporter, member 2; PERV-A receptor 2 homolog; Porcine endogenous retrovirus A receptor 2 homolog; Protein GPR172B; Riboflavin transporter 1; mRFT1", "protein_names_refseq": "G protein-coupled receptor 172B; PERV-A receptor 2 homolog; porcine endogenous retrovirus A receptor 2 homolog; riboflavin transporter 1; solute carrier family 52, riboflavin transporter, member 2", "tax_id": 10090, "disease": "Brown-Vialetto-Van Laere syndrome (Disease Ontology:DOID:0050694); Brown-Vialetto-Van Laere syndrome 2 (Disease Ontology:DOID:0080786); riboflavin deficiency (Disease Ontology:DOID:8454)", "pathway": " (mmu:52710); (R-MMU-196843)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;23911957;25428506;26495903;33518683;34428180;35820727", "class_list": "", "function": "Complete Deletion of Slc52a2 Causes Embryonic Lethality in Mice., [RefSeq, PubMed]; MRFVT2 was involved in hepatic riboflavin homeostasis, [RefSeq, PubMed]; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9474, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCV8", "ec_number_list": [], "go_molecular_function": "GO:0032217 riboflavin transmembrane transporter activity;GO:0062124 4-hydroxybutyrate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032218 riboflavin transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9D8F3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQC5-1", "uniprot_id": [ { "id": "SCYL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQC5", "type": "external" } ], "mass": 89160.0, "length": 806, "protein_name": "N-terminal kinase-like protein", "gene_name": "Scyl1", "organism": "Mouse", "refseq_name": "N-terminal kinase-like protein isoform 1", "refseq_ac": [ { "id": "NP_076401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076401", "type": "external" } ], "gene_names_uniprotkb": "Scyl1", "gene_names_refseq": "2810011O19Rik; Ntkl; Scyl1; mdf; mfd; p105", "protein_names_uniprotkb": "N-terminal kinase-like protein; 105 kDa kinase-like protein; Mitosis-associated kinase-like protein NTKL; SCY1-like protein 1", "protein_names_refseq": "105 kDa kinase-like protein; N-terminal kinase-like protein isoform 1; N-terminal kinase-like protein; SCY1-like protein 1; mitosis-associated kinase-like protein NTKL; ubiquitous protein kinase-like (105 kDa)", "tax_id": 10090, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); autosomal recessive spinocerebellar ataxia 21 (Disease Ontology:DOID:0111155)", "pathway": " (mmu:78891)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;11118629;12783284;17571074;18556652;21750661;26495903;29437892;37828378", "class_list": "", "function": "Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SCYL1 and SCYL3 play overlapping roles in maintaining motor neuronal viability in vivo and confirm that SCYL family members are critical regulators of neuronal function and survival, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9820, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TST7;Q3UKU0;Q8K222", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0006954 inflammatory response;GO:0021522 spinal cord motor neuron differentiation;GO:0008104 intracellular protein localization;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9EQC5-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKZ2-1", "uniprot_id": [ { "id": "SC5A3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKZ2", "type": "external" } ], "mass": 79583.0, "length": 718, "protein_name": "Sodium/myo-inositol cotransporter", "gene_name": "Slc5a3", "organism": "Mouse", "refseq_name": "sodium/myo-inositol cotransporter", "refseq_ac": [ { "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "type": "external" } ], "gene_names_uniprotkb": "Slc5a3", "gene_names_refseq": "Slc5a3; Smit1", "protein_names_uniprotkb": "Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; SMIT1; Sodium/myo-inositol transporter 1; Solute carrier family 5 member 3", "protein_names_refseq": "Na(+)/myo-inositol cotransporter; sodium myo-inositol transporter 1; sodium/myo-inositol cotransporter; solute carrier family 5, member 3; solute carrier family 5, member alpha 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:53881); (R-MMU-429593)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;10773690;12582158;12719585;19144319;24595108;25428506;27922641;28695546;30084848;31219806;34428180", "class_list": "", "function": "(Microbial infection) Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry., [UniProtKB, PubMed]; Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (PubMed:12582158, PubMed:24595108). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (By similarity) (PubMed:24595108). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior Publication Status: Online-Only, [RefSeq, PubMed]; SMIT1 overexpression contributes to abnormal cholinergic and glutamatergic Ca(2+) signals in the trisomic condition, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9452, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RU60", "ec_number_list": [], "go_molecular_function": "GO:0005367 myo-inositol:sodium symporter activity;GO:0005412 D-glucose:sodium symporter activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007422 peripheral nervous system development;GO:1903428 positive regulation of reactive oxygen species biosynthetic process;GO:0043576 regulation of respiratory gaseous exchange;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JKZ2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMA9-1", "uniprot_id": [ { "id": "S6A14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMA9", "type": "external" } ], "mass": 71456.0, "length": 638, "protein_name": "Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)", "gene_name": "Slc6a14", "organism": "Mouse", "refseq_name": "sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)", "refseq_ac": [ { "id": "NP_064433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064433", "type": "external" } ], "gene_names_uniprotkb": "Slc6a14", "gene_names_refseq": "1110007A17Rik; 9030613J17Rik; ATB0plus; CATB0plus; Slc6a14", "protein_names_uniprotkb": "Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Amino acid transporter ATB0+; Colonic system B0+ amino acid transporter CATB0+; Solute carrier family 6 member 14", "protein_names_refseq": "amino acid transporter ATB0+; colonic system B0+ amino acid transporter CATB0+; sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); solute carrier family 6 member 14", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); osteoporosis (Disease Ontology:DOID:11476); male infertility (Disease Ontology:DOID:12336); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); cystic fibrosis (Disease Ontology:DOID:1485); gastrointestinal system disease (Disease Ontology:DOID:77); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:56774); (R-MMU-352230); (R-MMU-442660)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11306607;11306651;11447016;25428506;30084848;30779550;32219372;35212370", "class_list": "", "function": "Amino acid transporter that plays an important role in the absorption of amino acids in the intestinal tract. Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (PubMed:11306607, PubMed:11447016). Transports non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinity for dipolar and cationic amino acids such as leucine and lysine (By similarity). Can also transport carnitine, butyrylcarnitine and propionylcarnitine coupled to the transmembrane gradients of Na(+) and Cl(-) (PubMed:11306651)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer., [RefSeq, PubMed]; SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q91Y60;Q9D317;Q9R183", "ec_number_list": [], "go_molecular_function": "GO:0005275 amine transmembrane transporter activity;GO:0015173 aromatic amino acid transmembrane transporter activity;GO:0022858 alanine transmembrane transporter activity;GO:1901235 (R)-carnitine transmembrane transporter activity;GO:0001761 beta-alanine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0032328 alanine transport;GO:0009636 response to toxic substance;GO:0035725 sodium ion transmembrane transport;GO:1903804 glycine import across plasma membrane;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JMA9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R053-1", "uniprot_id": [ { "id": "SCNBA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R053", "type": "external" } ], "mass": 201385.0, "length": 1765, "protein_name": "Sodium channel protein type 11 subunit alpha", "gene_name": "Scn11a", "organism": "Mouse", "refseq_name": "sodium channel protein type 11 subunit alpha", "refseq_ac": [ { "id": "NP_036017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036017", "type": "external" } ], "gene_names_uniprotkb": "Scn11a; Nan; Nat; Sns2", "gene_names_refseq": "NSS2; NaN; NaT; NaV1.9; SNS2; Scn11a", "protein_names_uniprotkb": "Sodium channel protein type 11 subunit alpha; NaN; Sensory neuron sodium channel 2; Sodium channel protein type XI subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.9", "protein_names_refseq": "sensory neuron sodium channel 2; sodium channel protein type 11 subunit alpha; sodium channel protein type XI subunit alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subunit alpha Nav1.9", "tax_id": 10090, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); hereditary sensory and autonomic neuropathy type 7 (Disease Ontology:DOID:0070149); Dravet syndrome (Disease Ontology:DOID:0080422); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); familial episodic pain syndrome 3 (Disease Ontology:DOID:0111731); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:24046)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10444332;10623609;14515348;24036948;25428506;30084848", "class_list": "", "function": "Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:24036948). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948). Also involved in rapid BDNF-evoked neuronal depolarization (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 5, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "E9QM88;Q9JMD4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0017134 fibroblast growth factor binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0044297 cell body", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0070417 cellular response to cold;GO:0061368 behavioral response to formalin induced pain;GO:0060004 reflex;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R053-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T4-1", "uniprot_id": [ { "id": "SEPT6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1T4", "type": "external" } ], "mass": 49620.0, "length": 434, "protein_name": "Septin-6", "gene_name": "Septin6", "organism": "Mouse", "refseq_name": "septin-6 isoform 3", "refseq_ac": [ { "id": "NP_001170794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170794", "type": "external" } ], "gene_names_uniprotkb": "Septin6; Kiaa0128; Sept6", "gene_names_refseq": "2810035H17Rik; C920001C06Rik; Sep6; Sept6; Septin6; mKIAA0128", "protein_names_uniprotkb": "Septin-6", "protein_names_refseq": "septin-6 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56526)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;11064363;17114649;20181826;21750661;25588830;29400567;31219806;33664458;34428180;36210013", "class_list": "", "function": "Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)., [UniProtKB, UniProtKB]; LSD1-mediated stabilization of SEPT6 protein activates the TGF-beta1 pathway and regulates non-small-cell lung cancer metastasis., [RefSeq, PubMed]; Sept6 and Pigx might participate in the pathogenesis of high blood pressure., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A3V9;A2A3W0;Q3TRH9;Q3TUA2;Q542H3;Q6A0C4;Q8C2L2;Q8C848;Q91XH2;Q9CZ94", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005940 septin ring;GO:0032173 septin collar;GO:0005819 spindle;GO:0043679 axon terminus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007010 cytoskeleton organization;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9R1T4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z306-1", "uniprot_id": [ { "id": "S22A4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z306", "type": "external" } ], "mass": 62290.0, "length": 553, "protein_name": "Solute carrier family 22 member 4", "gene_name": "Slc22a4", "organism": "Mouse", "refseq_name": "solute carrier family 22 member 4 isoform 1", "refseq_ac": [ { "id": "NP_062661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062661", "type": "external" } ], "gene_names_uniprotkb": "Slc22a4; Octn1", "gene_names_refseq": "Octn1; Slc22a4", "protein_names_uniprotkb": "Solute carrier family 22 member 4; Octn1; Organic cation/carnitine transporter 1", "protein_names_refseq": "LSTP-Like 2; organic cation/carnitine transporter 1; solute carrier family 22 member 4 isoform 1; solute carrier family 22 member 4", "tax_id": 10090, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (mmu:30805); (R-MMU-549127); (R-MMU-6798163)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11010964;14531806;15832501;16729965;20224991;20601551;25428506;30084848;34428180;38112574", "class_list": "", "function": "Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke., [RefSeq, PubMed]; Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:11010964, PubMed:20224991, PubMed:20601551). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (By similarity). Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (PubMed:20224991, PubMed:20601551). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (By similarity). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (By similarity). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (PubMed:20224991). May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis (PubMed:11010964, PubMed:16729965). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005524 ATP binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0006641 triglyceride metabolic process;GO:0032496 response to lipopolysaccharide;GO:0043330 response to exogenous dsRNA;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z306-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ00-1", "uniprot_id": [ { "id": "SL9A9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ00", "type": "external" } ], "mass": 72133.0, "length": 644, "protein_name": "Sodium/hydrogen exchanger 9", "gene_name": "Slc9a9", "organism": "Mouse", "refseq_name": "sodium/hydrogen exchanger 9", "refseq_ac": [ { "id": "NP_808577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808577", "type": "external" } ], "gene_names_uniprotkb": "Slc9a9; Nhe9", "gene_names_refseq": "5730527A11Rik; 9930105B05; Nhe9; Slc9a9", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 9; NHE-9; Na(+)/H(+) exchanger 9; Solute carrier family 9 member 9", "protein_names_refseq": "Na(+)/H(+) exchanger 9; sodium/hydrogen exchanger 9; solute carrier family 9 member 9", "tax_id": 10090, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (mmu:331004); (R-MMU-425986)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17005858;24065030;26755066;29362376;34428180;35716776", "class_list": "", "function": "Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (PubMed:17005858). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:24065030, PubMed:29362376). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (PubMed:29362376). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (PubMed:35716776). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracellular pH (PubMed:17005858)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inactivation of NHE9 in mice reproduces behavioral features of autism spectrum disorders including impaired social interaction, repetitive behaviors, and altered sensory processing. Publication Status: Online-Only, [RefSeq, PubMed]; NHE9/Slc9a9 is expressed in the inner ear, [RefSeq, PubMed]; This is the first animal behavior study that links Slc9a9 to Autism spectrum disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U0X0", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0042742 defense response to bacterium;GO:0035725 sodium ion transmembrane transport;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BZ00-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4U3-1", "uniprot_id": [ { "id": "SFRP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4U3", "type": "external" } ], "mass": 35413.0, "length": 314, "protein_name": "Secreted frizzled-related protein 1", "gene_name": "Sfrp1", "organism": "Mouse", "refseq_name": "secreted frizzled-related protein 1 precursor", "refseq_ac": [ { "id": "NP_038862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038862", "type": "external" } ], "gene_names_uniprotkb": "Sfrp1", "gene_names_refseq": "2210415K03Rik; Sfrp1; sFRP-1", "protein_names_uniprotkb": "Secreted frizzled-related protein 1; sFRP-1", "protein_names_refseq": "secreted frizzled-related protein 1 precursor; secreted frizzled-related sequence protein 1", "tax_id": 10090, "disease": "leiomyoma (Disease Ontology:DOID:127); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719)", "pathway": " (mmu:20377)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10640709;15306229;19188438;27713059;34428180;38554160;38722977;38748896;9096311;9739103", "class_list": "", "function": "DeltaNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; SFRP1 decreases WNT-Mediated M2 macrophage marker expression in breast tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity)., [UniProtKB, PubMed]; Tumour necrosis factor alpha regulates the miR-27a-3p-Sfrp1 axis in a mouse model of osteoporosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08861;Q505A2;Q8R1J4", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0017147 Wnt-protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0046851 negative regulation of bone remodeling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C4U3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Z5-1", "uniprot_id": [ { "id": "SF3A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K4Z5", "type": "external" } ], "mass": 88545.0, "length": 791, "protein_name": "Splicing factor 3A subunit 1", "gene_name": "Sf3a1", "organism": "Mouse", "refseq_name": "splicing factor 3A subunit 1", "refseq_ac": [ { "id": "NP_080451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080451", "type": "external" } ], "gene_names_uniprotkb": "Sf3a1", "gene_names_refseq": "1200014H24Rik; 5930416L09Rik; Sf3a1", "protein_names_uniprotkb": "Splicing factor 3A subunit 1; SF3a120", "protein_names_refseq": "SF3a120; splicing factor 3 subunit 1; splicing factor 3A subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67465); (R-MMU-72163); (R-MMU-9770562)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "20173027;20484733;23806337;25428506;25605945;25658809;25874565;27802388;30084848;30779550;31219806;34428180;35820727;36852467;37828378;39627609;40997131", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes., [UniProtKB, UniProtKB]; In macrophages, SF3a has significant preference for mRNA splicing events within innate immune signaling pathways compared with other biological pathways, thereby affecting the splicing of specific genes in the TLR signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; Once inside the nucleus, P2X6 subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0M7;Q8C128;Q8C175;Q921T3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8K4Z5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZY9-1", "uniprot_id": [ { "id": "SF3B4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZY9", "type": "external" } ], "mass": 44356.0, "length": 424, "protein_name": "Splicing factor 3B subunit 4", "gene_name": "Sf3b4", "organism": "Mouse", "refseq_name": "splicing factor 3B subunit 4", "refseq_ac": [ { "id": "NP_694693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694693", "type": "external" } ], "gene_names_uniprotkb": "Sf3b4", "gene_names_refseq": "SF3b49; SF3b50; Sap49; Sf3b4", "protein_names_uniprotkb": "Splicing factor 3B subunit 4", "protein_names_refseq": "spliceosome associated protein 49; splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD", "tax_id": 10090, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); cervical cancer (Disease Ontology:DOID:4362); Nager acrofacial dysostosis (Disease Ontology:DOID:5768); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:107701); (R-MMU-72163); (R-MMU-72165); (R-MMU-9770562)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "25428506;25605945;30084848;31219806;34428180;37167859;40997131", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB]; Sf3b4 regulates chromatin remodeler splicing and Hox expression., [RefSeq, PubMed]; This gene encodes one of the subunits of splicing factor 3B. A similar gene in human encodes a protein that cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes, and also belongs with the minor U12-dependent spliceosome. [provided by RefSeq, May 2015]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8QZY9-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR46-1", "uniprot_id": [ { "id": "SKA2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR46", "type": "external" } ], "mass": 13725.0, "length": 120, "protein_name": "SKA complex subunit 2", "gene_name": "Ska2", "organism": "Mouse", "refseq_name": "SKA complex subunit 2", "refseq_ac": [ { "id": "NP_079653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079653", "type": "external" } ], "gene_names_uniprotkb": "Ska2; Fam33a", "gene_names_refseq": "1110001A07Rik; Fam33a; Ska2", "protein_names_uniprotkb": "SKA complex subunit 2; Protein FAM33A; Spindle and kinetochore-associated protein 2", "protein_names_refseq": "SKA complex subunit 2; family with sequence similarity 33, member A; spindle and kinetochore-associated protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66140); (R-MMU-141430); (R-MMU-141444); (R-MMU-2467813); (R-MMU-2500257); (R-MMU-5663220); (R-MMU-68877); (R-MMU-9648025)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "22336914;28528544;37132052;38528004", "class_list": "", "function": "Circ_0001387 regulates SKA2 to accelerate breast cancer progression through miR-136-5p., [RefSeq, PubMed]; Component of the SKA complex, a microtubule plus end-binding complex of the outer kinetochore that stabilizes spindle microtubule-kinetochore attachments, promotes alignment of chromosomes at the mitotic spindle equator (chromosome congression) and assists suppression of the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network complex, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components such as the SKA complex; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle. The SKA complex is loaded onto bioriented kinetochores and it facilitates chromosome congression by stabilizing microtubules together with MAPRE1, and end-on attachment of the NDC80 complex to depolymerizing spindle microtubules, thereby assisting the poleward-moving kinetochore in withstanding microtubule pulling forces. The complex associates with dynamic microtubule plus-ends and can track both depolymerizing and elongating microtubules. The complex recruits protein phosphatase 1 (PP1) to the kinetochore in prometaphase and metaphase, to oppose spindle assembly checkpoint signaling and promote the onset of anaphase. Binds directly to microtubules; but with a much lower affinity than SKA1 (By similarity). During meiosis the SKA complex stabilizes the meiotic spindle and is required for its migration to the cortex (PubMed:22336914)., [UniProtKB, UniProtKB, PubMed]; SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. Publication Status: Online-Only, [RefSeq, PubMed]; The Skas subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2KGY1", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005876 spindle microtubule;GO:0072687 meiotic spindle;GO:0000940 outer kinetochore", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CR46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Z3-1", "uniprot_id": [ { "id": "SKP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0Z3", "type": "external" } ], "mass": 47766.0, "length": 424, "protein_name": "S-phase kinase-associated protein 2", "gene_name": "Skp2", "organism": "Mouse", "refseq_name": "S-phase kinase-associated protein 2 isoform a", "refseq_ac": [ { "id": "NP_038815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038815", "type": "external" } ], "gene_names_uniprotkb": "Skp2", "gene_names_refseq": "4930500A04Rik; FBXL1; FWD1; Skp2; p45", "protein_names_uniprotkb": "S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/WD-40 protein 1; FWD1", "protein_names_refseq": "F-box protein Skp2; F-box/WD-40 protein 1; S-phase kinase-associated protein 2 isoform a; cyclin A/CDK2-associated protein p45", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (mmu:27401); (R-MMU-174178); (R-MMU-187577); (R-MMU-5689880); (R-MMU-68949); (R-MMU-69231); (R-MMU-8939902); (R-MMU-8951664); (R-MMU-9708530); (R-MMU-983168)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10790373;21750661;22464731;25428506;30084848;30366907;30413706;30779550;31219806;33649389;34428180;37850885;37871911", "class_list": "", "function": "A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis. Erratum:[Br J Dermatol. 2024 Jun 20;191(1):e1. doi: 10.1093/bjd/ljae157. PMID: 38709154], [RefSeq, PubMed]; SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis., [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:22464731). Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition (PubMed:10790373). Degradation of CDKN1B/p27kip also requires CKS1 (PubMed:10790373). Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1 (PubMed:22464731). Degradation of TAL1 also requires STUB1 (By similarity). Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2 (By similarity). Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration (By similarity). Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination (PubMed:22464731)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Through the ubiquitin-mediated proteasomal degradation of viral proteins may have an antiviral activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BSG7;Q8C8Y9;Q8CB22;Q99J53", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0005634 nucleus", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0000086 G2/M transition of mitotic cell cycle;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z0Z3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88697-1", "uniprot_id": [ { "id": "STK16_MOUSE", "url": "https://www.uniprot.org/uniprot/O88697", "type": "external" } ], "mass": 34382.0, "length": 305, "protein_name": "Serine/threonine-protein kinase 16", "gene_name": "Stk16", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 16", "refseq_ac": [ { "id": "NP_001264921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264921", "type": "external" } ], "gene_names_uniprotkb": "Stk16; Edpk; Krct; Mpsk1; Pkl12; Tsf1", "gene_names_refseq": "EDPK; Krct; MPSK; PKL12; Stk16; TSF-1", "protein_names_uniprotkb": "Serine/threonine-protein kinase 16; 2.7.10.2; 2.7.11.1; Edpk; Embryo-derived protein kinase; MPSK; Myristoylated and palmitoylated serine/threonine-protein kinase; Protein kinase Krct; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16", "protein_names_refseq": "TGF-beta-stimulated factor 1; embryo-derived protein kinase; kinase related to cerevisiae and thaliana; myristoylated and palmitoylated serine/threonine-protein kinase; serine/threonine-protein kinase 16; tyrosine-protein kinase STK16", "tax_id": 10090, "disease": "", "pathway": " (mmu:20872)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10364453;10947953;21750661;34428180;9712705;9817935;9878782", "class_list": "", "function": "Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UEG5;Q9JMJ0;Q9JMJ1;Q9QX00", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046777 protein autophosphorylation;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG65-1", "uniprot_id": [ { "id": "SSPO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CG65", "type": "external" } ], "mass": 534975.0, "length": 4998, "protein_name": "SCO-spondin", "gene_name": "Sspo", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sspo", "gene_names_refseq": "", "protein_names_uniprotkb": "SCO-spondin", "protein_names_refseq": "", "tax_id": 10090, "disease": "scoliosis (Disease Ontology:DOID:0060249); idiopathic scoliosis (Disease Ontology:DOID:0060250)", "pathway": " (mmu:243369); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12909363;21750661;31219806;34418053;34428180;35820727", "class_list": "", "function": "Involved in the modulation of neuronal aggregation (By similarity). May be involved in developmental events during the formation of the central nervous system (By similarity)., [UniProtKB, UniProtKB]; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 39, "predicted_n_glycosites": 37, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 2, "glyco_site_count": 46, "binding_glycan_count": 0, "secondary_ac_list": "E9QMN0", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q8CG65-1", "record_type": "protein", "filter_code": "0000000.1000111.000100.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80TY4-1", "uniprot_id": [ { "id": "ST18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80TY4", "type": "external" } ], "mass": 114750.0, "length": 1045, "protein_name": "Suppression of tumorigenicity 18 protein", "gene_name": "St18", "organism": "Mouse", "refseq_name": "suppression of tumorigenicity 18 protein", "refseq_ac": [ { "id": "NP_001231621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231621", "type": "external" } ], "gene_names_uniprotkb": "St18; Kiaa0535", "gene_names_refseq": "Myt3; NZF-3; Nzf3; St18; mKIAA0535", "protein_names_uniprotkb": "Suppression of tumorigenicity 18 protein", "protein_names_refseq": "neural zinc finger protein NZF-3; suppression of tumorigenicity 18 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:240690)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16920096;21750661;34418053", "class_list": "", "function": "Myt1, Myt3, and Ngn3 are induced by Mfng and have roles in Mfng-mediated repression of Notch signaling which could serve as a trigger for endocrine islet differentiation [Myt3], [RefSeq, PubMed]; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH00;Q3URH9;Q3UVB9;Q3UZN9;Q811B4;Q8K098", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80TY4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFD4-1", "uniprot_id": [ { "id": "SNX8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFD4", "type": "external" } ], "mass": 52059.0, "length": 459, "protein_name": "Sorting nexin-8", "gene_name": "Snx8", "organism": "Mouse", "refseq_name": "sorting nexin-8", "refseq_ac": [ { "id": "NP_758481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758481", "type": "external" } ], "gene_names_uniprotkb": "Snx8", "gene_names_refseq": "B130023O14Rik; Snx8", "protein_names_uniprotkb": "Sorting nexin-8", "protein_names_refseq": "sorting nexin-8", "tax_id": 10090, "disease": "", "pathway": " (mmu:231834)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "21183079;21750661;25428506;28528544;29180417;30084848;31219806;31361958;31511639;34203471;34231239;34428180;36210013", "class_list": "", "function": "Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD., [RefSeq, PubMed]; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity)., [UniProtKB]; SNX8 mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes., [RefSeq, PubMed]; SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. Erratum:[Cell Mol Immunol. 2021 Jun;18(6):1613-1614. doi: 10.1038/s41423-021-00682-z. PMID: 33958747], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BLI6;Q8BUQ7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034498 early endosome to Golgi transport;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8CFD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPG6-1", "uniprot_id": [ { "id": "SUMF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPG6", "type": "external" } ], "mass": 34737.0, "length": 308, "protein_name": "Inactive C-alpha-formylglycine-generating enzyme 2", "gene_name": "Sumf2", "organism": "Mouse", "refseq_name": "inactive C-alpha-formylglycine-generating enzyme 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080721", "type": "external" } ], "gene_names_uniprotkb": "Sumf2", "gene_names_refseq": "2610040F05Rik; Sumf2", "protein_names_uniprotkb": "Inactive C-alpha-formylglycine-generating enzyme 2; Sulfatase-modifying factor 2", "protein_names_refseq": "C-alpha-formylglycine-generating enzyme 2; inactive C-alpha-formylglycine-generating enzyme 2 isoform 1 precursor; inactive C-alpha-formylglycine-generating enzyme 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67902); (R-MMU-1663150); (R-MMU-9840310)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TZL1;Q3UUL0;Q9CZ47", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BPG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYN2-1", "uniprot_id": [ { "id": "SPCS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYN2", "type": "external" } ], "mass": 24978.0, "length": 226, "protein_name": "Signal peptidase complex subunit 2", "gene_name": "Spcs2", "organism": "Mouse", "refseq_name": "signal peptidase complex subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_079944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079944", "type": "external" } ], "gene_names_uniprotkb": "Spcs2; Spc25", "gene_names_refseq": "5730406I15Rik; Spcs2; mKIAA0102", "protein_names_uniprotkb": "Signal peptidase complex subunit 2; Microsomal signal peptidase 25 kDa subunit; SPase 25 kDa subunit", "protein_names_refseq": "SPase 25 kDa subunit; microsomal signal peptidase 25 kDa subunit; signal peptidase complex subunit 2 isoform 1", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:66624); (R-MMU-422085); (R-MMU-9768727)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "16452087;21750661;28528544;31219806;34428180;36288343;37507081;39927985", "class_list": "", "function": "Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THR2;Q80X74;Q921V8;Q9CXK1", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9CYN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3G5-1", "uniprot_id": [ { "id": "STX11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3G5", "type": "external" } ], "mass": 33369.0, "length": 287, "protein_name": "Syntaxin-11", "gene_name": "Stx11", "organism": "Mouse", "refseq_name": "syntaxin-11", "refseq_ac": [ { "id": "NP_083351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083351", "type": "external" } ], "gene_names_uniprotkb": "Stx11", "gene_names_refseq": "5830405C08Rik; Stx11", "protein_names_uniprotkb": "Syntaxin-11", "protein_names_refseq": "syntaxin-11", "tax_id": 10090, "disease": "familial hemophagocytic lymphohistiocytosis 4 (Disease Ontology:DOID:0110924)", "pathway": " (mmu:74732)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19169743;21388490;21750661;23042080;23160464;23190531;30811271;31599954;34428180;38198890;38722309", "class_list": "", "function": "Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11., [RefSeq, PubMed]; Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration., [RefSeq, PubMed]; Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect. Erratum:[J Exp Med. 2024 Jul 1;221(7):e2022112205142024c. doi: 10.1084/jem.2022112205142024c. PMID: 38771261], [RefSeq, PubMed]; Required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation, [RefSeq, PubMed]; Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages., [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:30811271, PubMed:38198890). Syntaxin-11/STX11 is an atypical lipid-anchored t-SNARE that forms a SNARE complex with the t-SNARE SNAP23 and the v-SNARE VAMP8. This SNARE complex plays a critical role in the regulated exocytosis of cytotoxic granules by natural killer (NK) cells and cytotoxic T-lymphocytes (PubMed:23042080, PubMed:23190531). In macrophages, STX11 regulates stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with SNAP23, thereby playing a critical role in microbial component recognition and the induction of innate and adaptive immunity (PubMed:30811271). In skeletal muscle satellite cells, STX11 cooperates with its cognate SNAREs VAMP4 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (PubMed:38198890). In another proposed mechanism, STX11 may function as a regulator of the SNARE VTI1B on late endosomes to regulate trafficking from late endosomes to lysosomes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0012505 endomembrane system;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043312 neutrophil degranulation;GO:0071346 cellular response to type II interferon;GO:0006887 exocytosis;GO:0001913 T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D3G5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L0T3-1", "uniprot_id": [ { "id": "SRB4D_MOUSE", "url": "https://www.uniprot.org/uniprot/A1L0T3", "type": "external" } ], "mass": 61916.0, "length": 586, "protein_name": "Scavenger receptor cysteine-rich domain-containing group B protein", "gene_name": "Ssc4d", "organism": "Mouse", "refseq_name": "scavenger receptor cysteine-rich domain-containing group B protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001153838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153838", "type": "external" } ], "gene_names_uniprotkb": "Ssc4d; Srcrb4d", "gene_names_refseq": "C330016E03Rik; S4D-SRCRB; SRCRB-S4D; Srcrb4d; Ssc4d", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich domain-containing group B protein; Four scavenger receptor cysteine-rich domains-containing protein; S4D-SRCRB", "protein_names_refseq": "four scavenger receptor cysteine-rich domains-containing protein; scavenger receptor cysteine rich domain containing, group B (4 domains); scavenger receptor cysteine-rich domain-containing group B protein isoform 1 precursor; scavenger receptor cysteine-rich domain-containing group B protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:109267)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L0T3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D695-1", "uniprot_id": [ { "id": "SPB7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D695", "type": "external" } ], "mass": 43050.0, "length": 380, "protein_name": "Serpin B7", "gene_name": "Serpinb7", "organism": "Mouse", "refseq_name": "serpin B7", "refseq_ac": [ { "id": "NP_081824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081824", "type": "external" } ], "gene_names_uniprotkb": "Serpinb7", "gene_names_refseq": "4631416M05Rik; Serpinb7; megsin; ovalbumin", "protein_names_uniprotkb": "Serpin B7; Megsin", "protein_names_refseq": "serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7; serine (or cysteine) proteinase inhibitor, clade B, member 7; serpin B7", "tax_id": 10090, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); nephritis (Disease Ontology:DOID:10952); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:116872)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11473647;16443768;21750661;21928229;30592269", "class_list": "", "function": "Diabetic nephropathy model in triple transgenic mice overexpressing RAGE, iNOS & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress, [RefSeq, PubMed]; In systemic inflammatory response syndrome (SIRS), SERPINB7 showed no difference in expression in immuneactivated tissues from systemic inflammatory response syndrome and control mice., [RefSeq, PubMed]; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin (By similarity)., [UniProtKB]; Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0032967 positive regulation of collagen biosynthetic process;GO:0030162 regulation of proteolysis;GO:0090362 positive regulation of platelet-derived growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D695-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28663-1", "uniprot_id": [ { "id": "SNAB_MOUSE", "url": "https://www.uniprot.org/uniprot/P28663", "type": "external" } ], "mass": 33557.0, "length": 298, "protein_name": "Beta-soluble NSF attachment protein", "gene_name": "Napb", "organism": "Mouse", "refseq_name": "beta-soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_062606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062606", "type": "external" } ], "gene_names_uniprotkb": "Napb; Snapb", "gene_names_refseq": "Brp14; E161; I47; Napb; SNARE; b-SNAP", "protein_names_uniprotkb": "Beta-soluble NSF attachment protein; Brain protein I47; N-ethylmaleimide-sensitive factor attachment protein beta; SNAP-beta", "protein_names_refseq": "N-ethylmaleimide-sensitive factor attachment protein beta; SNAP-beta; beta-soluble NSF attachment protein; brain protein 14; brain protein I47", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 107 (Disease Ontology:DOID:0070393); Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (mmu:17957); (R-MMU-204005); (R-MMU-6807878); (R-MMU-6811434); (R-MMU-6811438); (R-MMU-6811440)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;12106288;21040848;21750661;31599954;33300544;8455721", "class_list": "", "function": "Analysis of alpha- and betaSNAP deletion mutant neurons shows that the two N-Ethylmaleimide-Sensitive Factor cofactors support synaptic vesicle priming by determining the availability of free SNARE components Erratum:[Neuron. 2012 Feb 9;73(3):620], [RefSeq, PubMed]; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0035249 synaptic transmission, glutamatergic;GO:0002090 regulation of receptor internalization;GO:0010807 regulation of synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P28663-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ71-1", "uniprot_id": [ { "id": "STAC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ71", "type": "external" } ], "mass": 41000.0, "length": 360, "protein_name": "SH3 and cysteine-rich domain-containing protein 3", "gene_name": "Stac3", "organism": "Mouse", "refseq_name": "SH3 and cysteine-rich domain-containing protein 3", "refseq_ac": [ { "id": "NP_808375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808375", "type": "external" } ], "gene_names_uniprotkb": "Stac3", "gene_names_refseq": "9830125E18; Stac3", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein 3", "protein_names_refseq": "SH3 and cysteine-rich domain-containing protein 3", "tax_id": 10090, "disease": "congenital myopathy 13 (Disease Ontology:DOID:0060346)", "pathway": " (mmu:237611)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;23626854;23818578;24788338;25548159;27621462;28112192;29363593;29467163;30071129;33409656;39927985", "class_list": "", "function": "Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization (PubMed:23818578, PubMed:27621462, PubMed:29467163). Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction (PubMed:23818578). Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane (PubMed:27621462). Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (PubMed:25548159, PubMed:27621462, PubMed:29467163). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:25548159, PubMed:29363593)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; RyR1 Ca2+ release by CaV1.1 depends on Stac3 being bound to critical domain residues in the II-III loop., [RefSeq, PubMed]; STAC3 mediates voltage-induced Ca2+ release and contractility in skeletal muscles., [RefSeq, PubMed]; Stac3 gene plays a critical role in skeletal muscle development and function in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Stac3 may play a role in preventing precocious myoblast differentiation during skeletal muscle development Erratum:[PLoS One. 2014;9(8):e105240] Publication Status: Online-Only, [RefSeq, PubMed]; Testicular STAC3 regulates Leydig cell steroidogenesis through potentiating mitochondrial membrane potential and StAR processing., [RefSeq, PubMed]; Thus, the C1 domain of STAC3 is responsible for its stable incorporation into the voltage-sensor (CaV1.1) of excitation-contraction-coupling complex, whereas the SH3 domain containing the Native American myopathy mutation site may be involved in low-affinity functional interactions in excitation-contraction-coupling. Publication Status: Online-Only, [RefSeq, PubMed]; We provide evidence that endogenous STAC3 incorporates into triads in the absence of the DHPR in myotubes and muscle fibers of dysgenic mice. This finding demonstrates that STAC3 interacts with additional triad proteins and is consistent with its proposed role in directly or indirectly linking the DHPR with the RyR1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0009898 cytoplasmic side of plasma membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007274 neuromuscular synaptic transmission;GO:0048741 skeletal muscle fiber development;GO:1903078 positive regulation of protein localization to plasma membrane;GO:1901387 positive regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BZ71-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZW0-1", "uniprot_id": [ { "id": "STK35_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZW0", "type": "external" } ], "mass": 59459.0, "length": 539, "protein_name": "Serine/threonine-protein kinase 35", "gene_name": "Stk35", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 35 isoform a", "refseq_ac": [ { "id": "NP_899085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899085", "type": "external" } ], "gene_names_uniprotkb": "Stk35; Stk35l1", "gene_names_refseq": "1700054C12Rik; CLIK1; Stk35l1; Stk35", "protein_names_uniprotkb": "Serine/threonine-protein kinase 35; 2.7.11.1; Serine/threonine-protein kinase 35 L1", "protein_names_refseq": "CLP-36 interacting kinase; serine/threonine-protein kinase 35 L1; serine/threonine-protein kinase 35 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:67333)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ANF2;Q3TMD8;Q8BIC2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0010972 negative regulation of G2/M transition of mitotic cell cycle;GO:0110031 negative regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZW0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97306-1", "uniprot_id": [ { "id": "STAC_MOUSE", "url": "https://www.uniprot.org/uniprot/P97306", "type": "external" } ], "mass": 44319.0, "length": 403, "protein_name": "SH3 and cysteine-rich domain-containing protein", "gene_name": "Stac", "organism": "Mouse", "refseq_name": "SH3 and cysteine-rich domain-containing protein isoform 1", "refseq_ac": [ { "id": "NP_058549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058549", "type": "external" } ], "gene_names_uniprotkb": "Stac; Stac1", "gene_names_refseq": "Stac", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein; Src homology 3 and cysteine-rich domain-containing protein", "protein_names_refseq": "SH3 and cysteine-rich domain-containing protein isoform 1; SH3 and cysteine-rich domain-containing protein; SRC homology 3 and cysteine-rich domain-containing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20840)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "20736085;21750661;23818578;27149520;28112192;29363593;29467163;30016717;8954993", "class_list": "", "function": "Found STAC1 and STAC2 expressed in mutually exclusive fashion in adult DRG neurons; STAC1 marks peptidergic nociceptive neurons; STAC2 is expressed in subset of nonpeptidergic nociceptors, all trkB+ neurons and a subpopulation of proprioceptive neurons, [RefSeq, PubMed]; Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity (PubMed:27149520). Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity (PubMed:29467163). Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity (PubMed:29363593)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0030315 T-tubule", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0034605 cellular response to heat;GO:1903078 positive regulation of protein localization to plasma membrane;GO:2001259 positive regulation of cation channel activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P97306-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35906-1", "uniprot_id": [ { "id": "SPIB_MOUSE", "url": "https://www.uniprot.org/uniprot/O35906", "type": "external" } ], "mass": 29365.0, "length": 267, "protein_name": "Transcription factor Spi-B", "gene_name": "Spib", "organism": "Mouse", "refseq_name": "transcription factor Spi-B", "refseq_ac": [ { "id": "NP_063919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063919", "type": "external" } ], "gene_names_uniprotkb": "Spib", "gene_names_refseq": "Spi-B; Spib", "protein_names_uniprotkb": "Transcription factor Spi-B", "protein_names_refseq": "Ets transcription factor Spi-B; Spi-1/PU.1 related; transcription factor Spi-B", "tax_id": 10090, "disease": "", "pathway": " (mmu:272382)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10229183;11313289;11672537;11980719;12431391;21750661;34428180;36210013;37965309;8626664;8691135;9384589;9511763", "class_list": "", "function": "Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35907;O35909;O55199", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35906-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08032-1", "uniprot_id": [ { "id": "SPTA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P08032", "type": "external" } ], "mass": 279865.0, "length": 2415, "protein_name": "Spectrin alpha chain, erythrocytic 1", "gene_name": "Spta1", "organism": "Mouse", "refseq_name": "spectrin alpha chain, erythrocytic 1", "refseq_ac": [ { "id": "NP_035595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035595", "type": "external" } ], "gene_names_uniprotkb": "Spta1; Spna1; Spta", "gene_names_refseq": "Spna-1; Spna1; Spta1; ha; ihj; nmf4; sph", "protein_names_uniprotkb": "Spectrin alpha chain, erythrocytic 1; Erythroid alpha-spectrin", "protein_names_refseq": "alpha-spectrin 1, erythroid; erythroid alpha-spectrin; hemolytic anemia; neuroscience mutagenesis facility, 4; spectrin alpha 1; spectrin alpha chain, erythrocyte; spectrin alpha chain, erythrocytic 1; spherocytosis", "tax_id": 10090, "disease": "hereditary pyropoikilocytosis (Disease Ontology:DOID:0061026); hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); hereditary spherocytosis type 3 (Disease Ontology:DOID:0110918); sickle cell anemia (Disease Ontology:DOID:10923); hereditary spherocytosis (Disease Ontology:DOID:12971)", "pathway": " (mmu:20739); (R-MMU-375165); (R-MMU-445095); (R-MMU-5673001); (R-MMU-6807878)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21183079;25428506;29187734;3000887;30084848;30779550;35820727", "class_list": "", "function": "Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RWX6;P97502", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030054 cell junction;GO:0030424 axon;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0007009 plasma membrane organization;GO:0030036 actin cytoskeleton organization;GO:0030097 hemopoiesis;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P08032-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97440-1", "uniprot_id": [ { "id": "SLBP_MOUSE", "url": "https://www.uniprot.org/uniprot/P97440", "type": "external" } ], "mass": 31603.0, "length": 275, "protein_name": "Histone RNA hairpin-binding protein", "gene_name": "Slbp", "organism": "Mouse", "refseq_name": "histone RNA hairpin-binding protein isoform 1", "refseq_ac": [ { "id": "NP_033219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033219", "type": "external" } ], "gene_names_uniprotkb": "Slbp; Hbp", "gene_names_refseq": "Slbp", "protein_names_uniprotkb": "Histone RNA hairpin-binding protein; Histone stem-loop-binding protein", "protein_names_refseq": "histone RNA hairpin-binding protein isoform 1; histone RNA hairpin-binding protein; histone stem-loop-binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:20492); (R-MMU-159230); (R-MMU-73856); (R-MMU-77588)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12415002;15179368;16125165;18036581;19470752;21750661;30980108;34428180;8957003", "class_list": "", "function": "Histone synthesis in immature and maturing oocytes is governed by a translational control mechanism that is directly regulated by changes in the amount of SLBP, [RefSeq, PubMed]; Inhibition of NF kappa B in TNF alpha-treated primary mouse hepatocytes is associated with increased S-phase cell cycle retention and decreased stem loop binding protein., [RefSeq, PubMed]; RNA-binding protein involved in the histone pre-mRNA processing (PubMed:18036581). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:18036581). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (By similarity). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (PubMed:18036581). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (PubMed:19470752)., [UniProtKB, UniProtKB, PubMed, PubMed]; RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs., [UniProtKB, UniProtKB]; SLBP expression and activity differ in mouse oocytes and early embryos compared with somatic cells., [RefSeq, PubMed]; SLBP overexpression caused by Fbxo30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation. The finding uncovers an unidentified pathway-controlling chromosome segregation and cell progress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071207 histone pre-mRNA stem-loop binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0051028 mRNA transport;GO:0002191 cap-dependent translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97440-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97469-1", "uniprot_id": [ { "id": "SNAI2_MOUSE", "url": "https://www.uniprot.org/uniprot/P97469", "type": "external" } ], "mass": 30003.0, "length": 269, "protein_name": "Zinc finger protein SNAI2", "gene_name": "Snai2", "organism": "Mouse", "refseq_name": "zinc finger protein SNAI2", "refseq_ac": [ { "id": "NP_035545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035545", "type": "external" } ], "gene_names_uniprotkb": "Snai2; Slugh; Slug", "gene_names_refseq": "Slugh; Slug; Snai2; Snail2", "protein_names_uniprotkb": "Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2", "protein_names_refseq": "neural crest transcription factor Slug; protein snail homolog 2; slug, chicken homolog; zinc finger protein SNAI2", "tax_id": 10090, "disease": "carcinoma (Disease Ontology:DOID:305); piebaldism (Disease Ontology:DOID:3263); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (mmu:20583)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18331720;38451818;9182671;9838149", "class_list": "", "function": "Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice., [RefSeq, PubMed]; Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09096;Q9R211", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0060429 epithelium development;GO:0010957 negative regulation of vitamin D biosynthetic process;GO:0070563 negative regulation of vitamin D receptor signaling pathway;GO:2000647 negative regulation of stem cell proliferation;GO:2001028 positive regulation of endothelial cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97469-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U213-1", "uniprot_id": [ { "id": "SRAC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U213", "type": "external" } ], "mass": 73987.0, "length": 654, "protein_name": "Protein SERAC1", "gene_name": "Serac1", "organism": "Mouse", "refseq_name": "protein SERAC1 isoform 3", "refseq_ac": [ { "id": "NP_001104487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104487", "type": "external" } ], "gene_names_uniprotkb": "Serac1; D17Ertd141e", "gene_names_refseq": "4930511N22Rik; D17Ertd141e; Serac1", "protein_names_uniprotkb": "Protein SERAC1; Serine active site-containing protein 1", "protein_names_refseq": "protein SERAC1 isoform 3; protein SERAC1; serine active site-containing protein 1", "tax_id": 10090, "disease": "3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (Disease Ontology:DOID:0110001)", "pathway": " (mmu:321007)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15722415;25428506;30779550;35235340;35820727", "class_list": "", "function": "Facilitates the transport of serine from the cytosol to the mitochondria by interacting with and stabilizing Sideroflexin-1 (SFXN1), a mitochondrial serine transporter, playing a fundamental role in the one-carbon cycle responsible for the synthesis of nucleotides needed for mitochondrial DNA replication (PubMed:35235340). Plays an important role in the phosphatidylglycerol (PG) remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. Specifically involved in the exchange of the sn-1 acyl chain from PG 16:0/18:1(9Z) (also known as 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)) to PG 18:0/18:1(9Z) (also known as 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)), a step needed in the bis(monoacylglycerol)phosphate biosynthetic pathway. May have acyltransferase activity although the mechanism for PG remodeling has not been determined (By similarity)., [UniProtKB, PubMed, UniProtKB]; Role in proximal t-haplotype mediated mouse sterility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS62;Q9D2G7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036148 phosphatidylglycerol acyl-chain remodeling;GO:0030198 extracellular matrix organization;GO:0032367 intracellular cholesterol transport;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3U213-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4VAA7-1", "uniprot_id": [ { "id": "SNX33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4VAA7", "type": "external" } ], "mass": 65315.0, "length": 574, "protein_name": "Sorting nexin-33", "gene_name": "Snx33", "organism": "Mouse", "refseq_name": "sorting nexin-33", "refseq_ac": [ { "id": "NP_780692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780692", "type": "external" } ], "gene_names_uniprotkb": "Snx33; Sh3px3", "gene_names_refseq": "E130307J07Rik; Sh3px3; Snx33", "protein_names_uniprotkb": "Sorting nexin-33; SH3 and PX domain-containing protein 3", "protein_names_refseq": "SH3 and PX domain containing 3; SH3 and PX domain-containing protein 3; sorting nexin-33", "tax_id": 10090, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:235406)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18353773;18419754;25428506;26567222;31219806;34428180;35820727;36210013", "class_list": "", "function": "Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes (By similarity)., [UniProtKB]; SNX33 interferes with cellular PrP formation by modulation of PrP shedding, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPM5;Q8C832", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:2000010 positive regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q4VAA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6J9G1-1", "uniprot_id": [ { "id": "STYK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6J9G1", "type": "external" } ], "mass": 48121.0, "length": 429, "protein_name": "Tyrosine-protein kinase STYK1", "gene_name": "Styk1", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase STYK1 isoform a", "refseq_ac": [ { "id": "NP_766479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766479", "type": "external" } ], "gene_names_uniprotkb": "Styk1; Nok", "gene_names_refseq": "9130025L13; Nok; Styk1", "protein_names_uniprotkb": "Tyrosine-protein kinase STYK1; 2.7.10.2; Novel oncogene with kinase domain; Serine/threonine/tyrosine kinase 1; mNOK", "protein_names_refseq": "NOK kinase; mNOK; novel oncogene with kinase domain; tyrosine-protein kinase STYK1 isoform a; tyrosine-protein kinase STYK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:243659)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15150103;16322230;30690705;30758858;39415235", "class_list": "", "function": "High Styk1 expression is a hallmark of NK cells and that Styk1 is not essential for NK cell development, activation and antiviral functions., [RefSeq, PubMed]; Point mutations at either Y327 or Y356 dramatically blocked cellular transformation by NOK as examined by colony formation and cellular DNA synthesis., [RefSeq, PubMed]; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways., [UniProtKB, PubMed]; STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; Styk1 expression is specific for NK cells and selected NK-like innate T-cell subsets, but dispensable for their development and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZH6;Q8BZT1", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6J9G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3A1-1", "uniprot_id": [ { "id": "STMD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P3A1", "type": "external" } ], "mass": 31413.0, "length": 279, "protein_name": "Stathmin domain-containing protein 1", "gene_name": "Stmnd1", "organism": "Mouse", "refseq_name": "stathmin domain-containing protein 1", "refseq_ac": [ { "id": "NP_001005422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005422", "type": "external" } ], "gene_names_uniprotkb": "Stmnd1; Gm1574", "gene_names_refseq": "Gm1574; Stmnd1", "protein_names_uniprotkb": "Stathmin domain-containing protein 1", "protein_names_refseq": "stathmin domain-containing protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:380842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P3A1-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P8Y7-1", "uniprot_id": [ { "id": "SNX31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P8Y7", "type": "external" } ], "mass": 50862.0, "length": 439, "protein_name": "Sorting nexin-31", "gene_name": "Snx31", "organism": "Mouse", "refseq_name": "sorting nexin-31 isoform 2", "refseq_ac": [ { "id": "NP_001333951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333951", "type": "external" } ], "gene_names_uniprotkb": "Snx31", "gene_names_refseq": "4631426E05Rik; Snx31", "protein_names_uniprotkb": "Sorting nexin-31", "protein_names_refseq": "sorting nexin-31 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66696)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24914955;37053012", "class_list": "", "function": "An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in protein trafficking., [UniProtKB, UniProtKB]; These data support a model in which SNX31 mediates the endocytic degradation of uroplakins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BH14;Q9D690", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P8Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W37-1", "uniprot_id": [ { "id": "SPN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80W37", "type": "external" } ], "mass": 41032.0, "length": 358, "protein_name": "Snurportin-1", "gene_name": "Snupn", "organism": "Mouse", "refseq_name": "snurportin-1", "refseq_ac": [ { "id": "NP_848461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848461", "type": "external" } ], "gene_names_uniprotkb": "Snupn; Rnut1", "gene_names_refseq": "0610031A09Rik; Rnut1; Snupn1; Snupn", "protein_names_uniprotkb": "Snurportin-1; RNA U transporter 1", "protein_names_refseq": "RNA, U transporter 1; snurportin-1", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 29 (Disease Ontology:DOID:0061134); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)", "pathway": " (mmu:66069); (R-MMU-191859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000339 RNA cap binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0061015 snRNA import into nucleus;GO:0051259 protein complex oligomerization;GO:0051262 protein tetramerization;GO:0007010 cytoskeleton organization;GO:0006404 RNA import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80W37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YT5-1", "uniprot_id": [ { "id": "SPT20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YT5", "type": "external" } ], "mass": 88472.0, "length": 790, "protein_name": "Spermatogenesis-associated protein 20", "gene_name": "Spata20", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 20", "refseq_ac": [ { "id": "NP_659076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659076", "type": "external" } ], "gene_names_uniprotkb": "Spata20; Tisp78", "gene_names_refseq": "Spata20; Tisp78", "protein_names_uniprotkb": "Spermatogenesis-associated protein 20; Sperm-specific protein 411; Ssp411; Transcript increased in spermiogenesis 78 protein", "protein_names_refseq": "sperm protein SSP411; sperm-specific protein 411; spermatogenesis-associated protein 20; ssp411; transcript increased in spermiogenesis 78 protein", "tax_id": 10090, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (mmu:217116)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15223837;29247744;36402749;37039301", "class_list": "", "function": "May play a role in fertility regulation., [UniProtKB]; Regulation of BCRP expression and sulfasalazine pharmacokinetics by the nuclear receptor REV-ERBalpha., [RefSeq, PubMed]; Ssp411 mRNA and protein were detected exclusively in spermatids after step 9 during spermiogenesis in testis. Males are sterile in an Ssp411 expression-disrupted murine strain (Ssp411(PB/PB)). Ssp411 participates in the ubiquitin-proteasome system by interacting with PSMC3. Ssp411 is required for spermatogenesis and plays a role in sperm head shaping., [RefSeq, PubMed]; The role of SPATA2 in TNF signaling, cancer, and spermatogenesis. Review article Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80YT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810B9-1", "uniprot_id": [ { "id": "SLIK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810B9", "type": "external" } ], "mass": 109406.0, "length": 980, "protein_name": "SLIT and NTRK-like protein 3", "gene_name": "Slitrk3", "organism": "Mouse", "refseq_name": "SLIT and NTRK-like protein 3 precursor", "refseq_ac": [ { "id": "NP_942564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942564", "type": "external" } ], "gene_names_uniprotkb": "Slitrk3", "gene_names_refseq": "ST3; Slitrk3", "protein_names_uniprotkb": "SLIT and NTRK-like protein 3", "protein_names_refseq": "SLIT and NTRK-like protein 3 precursor; SLIT and NTRK-like protein 3; slit and trk like gene 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:386750); (R-MMU-388844); (R-MMU-9013423)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;14550773;20485683;29107521;31219806;33300544", "class_list": "", "function": "Findings reveal how unique postsynaptic Cell Adhesion Molecules neuroligin 2 and slitrk3 work in concert to control synaptogenesis and establish a general framework for GABAergic synapse development., [RefSeq, PubMed]; Suppresses neurite outgrowth., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6NZM5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0072553 terminal button organization;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0007409 axonogenesis;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q810B9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHW9-1", "uniprot_id": [ { "id": "SLNL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHW9", "type": "external" } ], "mass": 45595.0, "length": 410, "protein_name": "Schlafen-like protein 1", "gene_name": "Slfnl1", "organism": "Mouse", "refseq_name": "schlafen-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_808238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808238", "type": "external" } ], "gene_names_uniprotkb": "Slfnl1", "gene_names_refseq": "4933406A14Rik; Slfnl1", "protein_names_uniprotkb": "Schlafen-like protein 1", "protein_names_refseq": "schlafen-like protein 1 isoform 1; schlafen-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:194219)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149Q6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BHW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGN8-1", "uniprot_id": [ { "id": "SPRR4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGN8", "type": "external" } ], "mass": 8504.0, "length": 76, "protein_name": "Small proline-rich protein 4", "gene_name": "Sprr4", "organism": "Mouse", "refseq_name": "small proline-rich protein 4", "refseq_ac": [ { "id": "NP_775093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775093", "type": "external" } ], "gene_names_uniprotkb": "Sprr4", "gene_names_refseq": "Sprr4", "protein_names_uniprotkb": "Small proline-rich protein 4", "protein_names_refseq": "small proline-rich protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:229562)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12584609", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KNY6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CGN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1Q0-1", "uniprot_id": [ { "id": "STX19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1Q0", "type": "external" } ], "mass": 33867.0, "length": 292, "protein_name": "Syntaxin-19", "gene_name": "Stx19", "organism": "Mouse", "refseq_name": "syntaxin-19", "refseq_ac": [ { "id": "NP_080864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080864", "type": "external" } ], "gene_names_uniprotkb": "Stx19; Syn9", "gene_names_refseq": "A030009B12Rik; Stx19", "protein_names_uniprotkb": "Syntaxin-19; Syntaxin-9", "protein_names_refseq": "syntaxin 9; syntaxin-19", "tax_id": 10090, "disease": "", "pathway": " (mmu:68159)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16420529", "class_list": "", "function": "Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR)., [UniProtKB, PubMed]; Syntaxin 9 interacts specifically with the epidermal growth factor receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTR6;Q9CV39", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1Q0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LZ3-1", "uniprot_id": [ { "id": "SLD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LZ3", "type": "external" } ], "mass": 25961.0, "length": 223, "protein_name": "DNA replication complex GINS protein SLD5", "gene_name": "Gins4", "organism": "Mouse", "refseq_name": "DNA replication complex GINS protein SLD5", "refseq_ac": [ { "id": "NP_077202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077202", "type": "external" } ], "gene_names_uniprotkb": "Gins4; Sld5", "gene_names_refseq": "2810037C03Rik; 4933405K01Rik; Gins4; Sld5", "protein_names_uniprotkb": "DNA replication complex GINS protein SLD5; GINS complex subunit 4", "protein_names_refseq": "DNA replication complex GINS protein SLD5; GINS complex subunit 4 (Sld5 homolog)", "tax_id": 10090, "disease": "", "pathway": " (mmu:109145); (R-MMU-176974)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16338220;24244394;31050118", "class_list": "", "function": "Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle., [RefSeq, PubMed]; Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]; Requirement of SLD5 for early embryogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that PSF1 and SLD5 may cooperate in the proliferation of immature cell populations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP06", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication;GO:0006261 DNA-templated DNA replication;GO:0001833 inner cell mass cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99LZ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PE5-1", "uniprot_id": [ { "id": "SMIM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PE5", "type": "external" } ], "mass": 6526.0, "length": 60, "protein_name": "Small integral membrane protein 3", "gene_name": "Smim3", "organism": "Mouse", "refseq_name": "small integral membrane protein 3", "refseq_ac": [ { "id": "NP_598894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598894", "type": "external" } ], "gene_names_uniprotkb": "Smim3; Nid67", "gene_names_refseq": "2010002N04Rik; Nid67; Smim3; cI-41", "protein_names_uniprotkb": "Small integral membrane protein 3; NGF-induced differentiation clone 67 protein; Small membrane protein NID67", "protein_names_refseq": "NGF-induced differentiation clone 67 protein; putative small membrane protein NID67; small integral membrane protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106878)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11288140;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921E9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0I4-1", "uniprot_id": [ { "id": "STX17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0I4", "type": "external" } ], "mass": 33221.0, "length": 301, "protein_name": "Syntaxin-17", "gene_name": "Stx17", "organism": "Mouse", "refseq_name": "syntaxin-17", "refseq_ac": [ { "id": "NP_080619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080619", "type": "external" } ], "gene_names_uniprotkb": "Stx17", "gene_names_refseq": "4833418L03Rik; 6330411F21Rik; 9030425C21Rik; Stx17", "protein_names_uniprotkb": "Syntaxin-17", "protein_names_refseq": "syntaxin-17", "tax_id": 10090, "disease": "", "pathway": " (mmu:67727); (R-MMU-204005)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21183079;21750661;23006999;23217709;27458136;27628032;32828953;34304694;35510944;36948287;38172666", "class_list": "", "function": "Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1., [RefSeq, PubMed]; Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice. Publication Status: Online-Only, [RefSeq, PubMed]; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity)., [UniProtKB, UniProtKB]; STING controls energy stress-induced autophagy and energy metabolism via STX17., [RefSeq, PubMed]; Study identifies syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome., [RefSeq, PubMed]; Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress., [RefSeq, PubMed]; Syntaxin-17 can be traced to the last eukaryotic common ancestor, hinting that the removal of damaged mitochondrial content may represent one of the earliest vesicle transport routes in the cell., [RefSeq, PubMed]; Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca[2+] overload in a Parkin-MCUb-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVI3;Q9D330", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0000149 SNARE binding;GO:0019903 protein phosphatase binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0000421 autophagosome membrane;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0034497 protein localization to phagophore assembly site;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9D0I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D198-1", "uniprot_id": [ { "id": "SYF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D198", "type": "external" } ], "mass": 28712.0, "length": 242, "protein_name": "Pre-mRNA-splicing factor SYF2", "gene_name": "Syf2", "organism": "Mouse", "refseq_name": "pre-mRNA-splicing factor SYF2", "refseq_ac": [ { "id": "NP_081056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081056", "type": "external" } ], "gene_names_uniprotkb": "Syf2; Cbpin; Gcipip", "gene_names_refseq": "1110018L13Rik; Cbpin; D4Bwg1551e; Gcipip; Ntc31; Syf2; mp29; p29", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SYF2; CCNDBP1-interactor; mp29; p29", "protein_names_refseq": "CCNDBP1 interactor; GCIP-interacting protein p29 (Gcipip); pre-mRNA-splicing factor SYF2", "tax_id": 10090, "disease": "encephalitis (Disease Ontology:DOID:9588)", "pathway": " (mmu:68592); (R-MMU-72163)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12437976;22448250;25605945;31219806;31599954;36210013", "class_list": "", "function": "Disruption of mp29/Syf2/Ntc31 gene results in embryonic lethality with aberrant checkpoint response., [RefSeq, PubMed]; Involved in pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]; Molecular cloning, expression, and genomic organization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0008284 positive regulation of cell population proliferation;GO:0007369 gastrulation;GO:0000398 mRNA splicing, via spliceosome;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D198-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9T6-1", "uniprot_id": [ { "id": "SPTA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9T6", "type": "external" } ], "mass": 20947.0, "length": 193, "protein_name": "Spermatogenesis-associated protein 3", "gene_name": "Spata3", "organism": "Mouse", "refseq_name": "spermatogenesis-associated protein 3 isoform 3", "refseq_ac": [ { "id": "NP_001116204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116204", "type": "external" } ], "gene_names_uniprotkb": "Spata3; Tsarg1", "gene_names_refseq": "1700011N12Rik; 1700029H01Rik; 4930424D10Rik; Mtsarg1; Spata3; Tsarg1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 3; Testis and spermatogenesis cell-related protein 1; Testis spermatocyte apoptosis-related protein 1; mTSARG1", "protein_names_refseq": "spermatogenesis-associated protein 3 isoform 3; spermatogenesis-associated protein 3; testis and spermatogenesis cell apoptosis related gene 1; testis and spermatogenesis cell apoptosis related protein 1; testis and spermatogenesis cell-related protein 1; testis spermatocyte apoptosis-related protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:70060)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12812072;18551385;21750661;27053129;33669425", "class_list": "", "function": "Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice. Publication Status: Online-Only, [RefSeq, PubMed]; Mtsarg1 and Mtsarg1-beta may play an important role in mouse testicular function and in spermatocyte development., [RefSeq, PubMed]; Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZS4;Q9D5L5;Q9DAF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D9T6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA21-1", "uniprot_id": [ { "id": "SMCO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA21", "type": "external" } ], "mass": 39357.0, "length": 347, "protein_name": "Single-pass membrane and coiled-coil domain-containing protein 2", "gene_name": "Smco2", "organism": "Mouse", "refseq_name": "single-pass membrane and coiled-coil domain-containing protein 2", "refseq_ac": [ { "id": "NP_081335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081335", "type": "external" } ], "gene_names_uniprotkb": "Smco2", "gene_names_refseq": "1700023A16Rik; Smco2", "protein_names_uniprotkb": "Single-pass membrane and coiled-coil domain-containing protein 2", "protein_names_refseq": "single-pass membrane and coiled-coil domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:69371)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21183079", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBE9-1", "uniprot_id": [ { "id": "SPB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBE9", "type": "external" } ], "mass": 95532.0, "length": 838, "protein_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "gene_name": "Ftsj3", "organism": "Mouse", "refseq_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "refseq_ac": [ { "id": "NP_079586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079586", "type": "external" } ], "gene_names_uniprotkb": "Ftsj3", "gene_names_refseq": "D11Ertd400e; Epcs3; Ftsj3", "protein_names_uniprotkb": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; 2.1.1.-; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3", "protein_names_refseq": "2'-O-ribose RNA methyltransferase SPB1 homolog; FtsJ RNA methyltransferase homolog 3; FtsJ homolog 3; ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3; pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; pre-rRNA processing protein FTSJ3; protein ftsJ homolog 3; putative rRNA methyltransferase 3; rRNA (uridine-2'-O-)-methyltransferase 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:56095); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;17622165;21183079;24463520;30084848;30779550;31219806;34428180;34887587;35820727;37828378;37963197", "class_list": "", "function": "RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., [UniProtKB, HAMAP]; RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ULI1;Q921I7", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0005694 chromosome;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0031167 rRNA methylation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001510 RNA methylation;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DBE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQC9-1", "uniprot_id": [ { "id": "SAR1B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQC9", "type": "external" } ], "mass": 22382.0, "length": 198, "protein_name": "Small COPII coat GTPase SAR1B", "gene_name": "Sar1b", "organism": "Mouse", "refseq_name": "small COPII coat GTPase SAR1B", "refseq_ac": [ { "id": "NP_079811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079811", "type": "external" } ], "gene_names_uniprotkb": "Sar1b; Sara1b; Sara2", "gene_names_refseq": "2310075M17Rik; 2900019I22Rik; CMRD; Sar1b; Sara1b; Sara2; Sarb", "protein_names_uniprotkb": "Small COPII coat GTPase SAR1B; 3.6.5.2", "protein_names_refseq": "GTP-binding protein SAR1b; SAR1 gene homolog B; SAR1a gene homolog 2; SAR1b gene homolog; small COPII coat GTPase SAR1B", "tax_id": 10090, "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)", "pathway": " (mmu:66397); (R-MMU-204005); (R-MMU-2132295); (R-MMU-5694530); (R-MMU-8963888); (R-MMU-983170)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11422940;22872234;24969168;31219806;33186557;33964306;34428180;36210013;37453647;37558128;38687799", "class_list": "", "function": "Data suggest the importance of small Sar1b GTPase (Sar1b) in organs involved in lipid transport and/or calcium trafficking such as the liver, intestine, skeletal muscle and heart., [RefSeq, PubMed]; Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo., [RefSeq, PubMed]; High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism., [RefSeq, PubMed]; Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi (By similarity). In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis (PubMed:33186557). In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UBL6", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0140785 amino acid sensor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0042953 lipoprotein transport;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9CQC9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKX8-1", "uniprot_id": [ { "id": "UPK3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKX8", "type": "external" } ], "mass": 30990.0, "length": 287, "protein_name": "Uroplakin-3a", "gene_name": "Upk3a", "organism": "Mouse", "refseq_name": "uroplakin-3a precursor", "refseq_ac": [ { "id": "NP_075967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075967", "type": "external" } ], "gene_names_uniprotkb": "Upk3a; Upk3", "gene_names_refseq": "1110017C07Rik; UP3a; UPIII; Upk3a; Upk3", "protein_names_uniprotkb": "Uroplakin-3a; UP3a; UPIII; Uroplakin III", "protein_names_refseq": "proplakin IIIa; uroplakin 3; uroplakin III; uroplakin-3a precursor; uroplakin-3a", "tax_id": 10090, "disease": "vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (mmu:22270)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16814572", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q27QV3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0001822 kidney development;GO:0000902 cell morphogenesis;GO:0006833 water transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKX8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24604-1", "uniprot_id": [ { "id": "TEC_MOUSE", "url": "https://www.uniprot.org/uniprot/P24604", "type": "external" } ], "mass": 73426.0, "length": 630, "protein_name": "Tyrosine-protein kinase Tec", "gene_name": "Tec", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase Tec isoform a", "refseq_ac": [ { "id": "NP_001106931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106931", "type": "external" } ], "gene_names_uniprotkb": "Tec", "gene_names_refseq": "Tec", "protein_names_uniprotkb": "Tyrosine-protein kinase Tec; 2.7.10.2", "protein_names_refseq": "cytoplasmic tyrosine kinase, Dscr28C related; protein tyrosine kinase TecIIA; protein tyrosine kinase TecIIB; protein tyrosine kinase TecIII; protein tyrosine kinase TecIV; protein tyrosine kinase TecI; tyrosine-protein kinase Tec isoform a; tyrosine-protein kinase Tec", "tax_id": 10090, "disease": "", "pathway": " (mmu:21682); (R-MMU-1433557); (R-MMU-2871809); (R-MMU-512988)", "pathway_count": 4, "publication_count": 25, "publication_id_list": "10343129;10382746;11684687;15214045;15817477;17947660;19144319;19688741;20543088;21094130;21750661;2284097;23478294;2482828;28275136;28415764;29129599;29348675;35003062;35820727;7678927;8621063;8877094;9473212;9872994", "class_list": "", "function": "Inhibition of ITK and RLK attenuated psoriasis-associated signaling pathways, indicating that PRN694 is an effective psoriasis therapeutic., [RefSeq, PubMed]; Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC also regulates FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 macrophages cells via NF-kappaB pathway., [RefSeq, PubMed]; The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; These data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1M9;Q9WVN0;Q9WVN1;Q9WVN2;Q9WVN3", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0010543 regulation of platelet activation;GO:0007229 integrin-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P24604-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUN2-1", "uniprot_id": [ { "id": "TBK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUN2", "type": "external" } ], "mass": 83425.0, "length": 729, "protein_name": "Serine/threonine-protein kinase TBK1", "gene_name": "Tbk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase TBK1", "refseq_ac": [ { "id": "NP_062760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062760", "type": "external" } ], "gene_names_uniprotkb": "Tbk1", "gene_names_refseq": "1200008B05Rik; Tbk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase TBK1; 2.7.11.1; T2K; TANK-binding kinase 1", "protein_names_refseq": "T2K; serine/threonine-protein kinase TBK1", "tax_id": 10090, "disease": "frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (Disease Ontology:DOID:0110069); brain disease (Disease Ontology:DOID:936)", "pathway": " (mmu:56480); (R-MMU-168928); (R-MMU-3134975); (R-MMU-3249367); (R-MMU-3270619); (R-MMU-5205685); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-9008059); (R-MMU-936440); (R-MMU-936964); (R-MMU-9824878)", "pathway_count": 12, "publication_count": 22, "publication_id_list": "10581243;10990461;14679297;15210742;15661922;21750661;23376065;23396211;23746807;24368730;25605945;28159912;29155197;29718959;30101190;31219806;32034138;32849638;33459343;34245780;34428180;37828378", "class_list": "", "function": "Expression of IRF3-dependent genes in embryonic fibroblasts derived from Tbk1(-/-) mice, [RefSeq, PubMed]; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:10581243, PubMed:15210742, PubMed:15661922). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (By similarity). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (By similarity). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (By similarity). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (By similarity). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (By similarity). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (By similarity). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (By similarity). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (By similarity). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (By similarity). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, which leads to a negative impact on insulin sensitivity (PubMed:23396211). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (By similarity). Acts as a positive regulator of the mTORC2 complex by mediating phosphorylation of MTOR, leading to increased phosphorylation and activation of AKT1 (PubMed:34245780). Phosphorylates and activates AKT1 (By similarity). Involved in the regulation of TNF-induced RIPK1-mediated cell death, probably acting via CYLD phosphorylation that in turn controls RIPK1 ubiquitination status (By similarity). Also participates in the differentiation of T follicular regulatory cells together with the receptor ICOS (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CT90;Q9DC03", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032727 positive regulation of interferon-alpha production;GO:0006468 protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9WUN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M01-1", "uniprot_id": [ { "id": "SYFM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99M01", "type": "external" } ], "mass": 52337.0, "length": 451, "protein_name": "Phenylalanine--tRNA ligase, mitochondrial", "gene_name": "Fars2", "organism": "Mouse", "refseq_name": "phenylalanine--tRNA ligase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_077236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077236", "type": "external" } ], "gene_names_uniprotkb": "Fars2; Fars1", "gene_names_refseq": "Fars1; Fars2; pheRS", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase, mitochondrial; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase", "protein_names_refseq": "phenylalanine--tRNA ligase, mitochondrial isoform 1; phenylalanine--tRNA ligase, mitochondrial; phenylalanine-tRNA synthetase 1 (mitochondrial)", "tax_id": 10090, "disease": "hereditary spastic paraplegia 77 (Disease Ontology:DOID:0110822); combined oxidative phosphorylation deficiency 14 (Disease Ontology:DOID:0111477); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202)", "pathway": " (mmu:69955)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;25428506;34428180;38362779", "class_list": "", "function": "FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System., [RefSeq, PubMed]; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBZ7;Q9CYY0", "ec_number_list": [ { "id": "6.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008033 tRNA processing;GO:0006432 phenylalanyl-tRNA aminoacylation;GO:0006412 translation;GO:0043039 tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99M01-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMY4-1", "uniprot_id": [ { "id": "THOC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMY4", "type": "external" } ], "mass": 23715.0, "length": 204, "protein_name": "THO complex subunit 7 homolog", "gene_name": "Thoc7", "organism": "Mouse", "refseq_name": "THO complex subunit 7 homolog isoform 3", "refseq_ac": [ { "id": "NP_001272709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272709", "type": "external" } ], "gene_names_uniprotkb": "Thoc7; Nif3l1bp1", "gene_names_refseq": "Nif3l1bp1; Thoc7", "protein_names_uniprotkb": "THO complex subunit 7 homolog; Ngg1-interacting factor 3-like protein 1-binding protein 1", "protein_names_refseq": "THO complex 7 homolog; THO complex subunit 7 homolog isoform 3; THO complex subunit 7 homolog; ngg1-interacting factor 3-like protein 1-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66231); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12951069;16465402;21750661;22872234;24618812;31219806;34428180", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UIA6;Q80VT4;Q9CQ50", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7TMY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV96-1", "uniprot_id": [ { "id": "T10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV96", "type": "external" } ], "mass": 11314.0, "length": 100, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10 B", "gene_name": "Gm45799; Timm10b", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim10 B isoform d", "refseq_ac": [ { "id": "NP_062375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062375", "type": "external" } ], "gene_names_uniprotkb": "Gm45799; Timm10b; Fxc1; Gm45799; Tim9b; Timm9b", "gene_names_refseq": "Fxc1; Tim10b; Tim9b; Timm10b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10 B; Mitochondrial import inner membrane translocase subunit Tim9 B; TIMM10B; Tim10b", "protein_names_refseq": "Fracture Callus 1; fractured callus 1; fractured callus expressed transcript 1; mitochondrial import inner membrane translocase subunit Tim10 B isoform d; mitochondrial import inner membrane translocase subunit Tim10 B; mitochondrial import inner membrane translocase subunit Tim9 B; small zinc finger-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:14356)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10611480;21750661", "class_list": "", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q545D2;Q9DCB5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WV96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PHN7-1", "uniprot_id": [ { "id": "TM164_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PHN7", "type": "external" } ], "mass": 33441.0, "length": 296, "protein_name": "Transmembrane protein 164", "gene_name": "Tmem164", "organism": "Mouse", "refseq_name": "transmembrane protein 164 isoform a", "refseq_ac": [ { "id": "NP_001186289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186289", "type": "external" } ], "gene_names_uniprotkb": "Tmem164", "gene_names_refseq": "F730011B02; Tmem164", "protein_names_uniprotkb": "Transmembrane protein 164; Arachidonoyl ether phospholipid synthase", "protein_names_refseq": "arachidonoyl ether phospholipid synthase; transmembrane protein 164 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:209497)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;31219806;35947500;37679556;39392409", "class_list": "", "function": "Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice., [RefSeq, PubMed]; Positive regulator of ferroptosis. Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death., [UniProtKB, UniProtKB]; TMEM164 is a new determinant of autophagy-dependent ferroptosis., [RefSeq, PubMed]; TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0160020 positive regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6PHN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZM7-1", "uniprot_id": [ { "id": "T2AG_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80ZM7", "type": "external" } ], "mass": 12473.0, "length": 109, "protein_name": "Transcription initiation factor IIA subunit 2", "gene_name": "Gtf2a2", "organism": "Mouse", "refseq_name": "transcription initiation factor IIA subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_001034608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034608", "type": "external" } ], "gene_names_uniprotkb": "Gtf2a2", "gene_names_refseq": "Gtf2a2; TFIIA-gamma; TfIIg; Tfiia2", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 2; General transcription factor IIA subunit 2; TFIIA-gamma; Transcription initiation factor IIA gamma chain", "protein_names_refseq": "general transcription factor IIA, 2 (12kD subunit); transcription initiation factor IIA gamma chain; transcription initiation factor IIA subunit 2 isoform 1; transcription initiation factor IIA subunit 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:235459); (R-MMU-674695); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042); (R-MMU-9018519)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005672 transcription factor TFIIA complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2K4-1", "uniprot_id": [ { "id": "TAF6L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2K4", "type": "external" } ], "mass": 67236.0, "length": 616, "protein_name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L", "gene_name": "Taf6l", "organism": "Mouse", "refseq_name": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 2", "refseq_ac": [ { "id": "NP_001171269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171269", "type": "external" } ], "gene_names_uniprotkb": "Taf6l; Paf65a", "gene_names_refseq": "2810417N14Rik; C530024J06Rik; Paf65a; Taf6l", "protein_names_uniprotkb": "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; PAF65-alpha; PCAF-associated factor 65-alpha; TAF6L", "protein_names_refseq": "PAF65-alpha; PCAF-associated factor 65-alpha; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform 2; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:225895)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "19574399;21750661;24129315;31005419;31219806;34203471;34428180;35820727", "class_list": "", "function": "Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419). Functions with MYC to activate target gene expression through RNA polymerase II pause release (PubMed:31005419)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Gonadotropin-releasing hormone-mediated phosphorylation of ERalpha in LbetaT2 pituitary cells results in its rapid association with p300-CBP-associated factor and the transcriptional activation of fosB., [RefSeq, PubMed]; TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5T2", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex;GO:0046695 SLIK (SAGA-like) complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0006282 regulation of DNA repair;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R2K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64324-1", "uniprot_id": [ { "id": "STXB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64324", "type": "external" } ], "mass": 66357.0, "length": 593, "protein_name": "Syntaxin-binding protein 2", "gene_name": "Stxbp2", "organism": "Mouse", "refseq_name": "syntaxin-binding protein 2 isoform 2", "refseq_ac": [ { "id": "NP_035633", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035633", "type": "external" } ], "gene_names_uniprotkb": "Stxbp2; Unc18b", "gene_names_refseq": "Munc-18-2; Munc-18b; Munc18b; Stxbp2; Sxtbp2; Sxtp2; Unc18-2; Unc18b; muSec1", "protein_names_uniprotkb": "Syntaxin-binding protein 2; Munc-18b; Munc18-2; Protein unc-18 homolog 2; Protein unc-18 homolog B; Unc-18B; Unc18-2; muSec1", "protein_names_refseq": "protein unc-18 homolog 2; protein unc-18 homolog B; syntaxin binding protein Munc18-2; syntaxin-binding protein 2 isoform 2", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); familial hemophagocytic lymphohistiocytosis 5 (Disease Ontology:DOID:0110925); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:20911); (R-MMU-114608); (R-MMU-449836)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;30696774;31219806;34203471;34428180;35604625;36210013;36944334;7890599;7890715", "class_list": "", "function": "Functions in intracellular vesicle trafficking through interaction with SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) which are essential proteins for membrane fusion. By promoting the assembly of functional STX11/SNAP23/VAMP8 SNARE complexes at the plasma membrane, regulates cytotoxic granule exocytosis in natural killer (NK) cells., [UniProtKB, UniProtKB]; Results indicate that Munc18-2, but not Munc18-1 or Munc18-3, is essential for regulated exocytosis in platelets and platelet participation in thrombosis and hemostasis., [RefSeq, PubMed]; STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion., [RefSeq, PubMed]; Syntaxin binding protein 2 in sertoli cells regulates spermatogonial stem cell maintenance through directly interacting with connexin 43 in the testes of neonatal mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0030348 syntaxin-3 binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030141 secretory granule;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043312 neutrophil degranulation;GO:0043306 positive regulation of mast cell degranulation;GO:0071346 cellular response to type II interferon;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64324-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0G2-1", "uniprot_id": [ { "id": "T3JAM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0G2", "type": "external" } ], "mass": 58564.0, "length": 513, "protein_name": "TRAF3-interacting JNK-activating modulator", "gene_name": "Traf3ip3", "organism": "Mouse", "refseq_name": "TRAF3-interacting JNK-activating modulator", "refseq_ac": [ { "id": "NP_694777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694777", "type": "external" } ], "gene_names_uniprotkb": "Traf3ip3; T3jam", "gene_names_refseq": "6030423D04Rik; T3jam; Traf3ip3", "protein_names_uniprotkb": "TRAF3-interacting JNK-activating modulator; TRAF3-interacting protein 3", "protein_names_refseq": "TRAF3-interacting JNK-activating modulator; TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator", "tax_id": 10090, "disease": "", "pathway": " (mmu:215243)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14572659;18313334;21750661;26011558;26195727;30115741;31076725;31390091;32366851;34428180", "class_list": "", "function": "Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30115741). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:30115741). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-triggered IFN-I production and reduced susceptibility to virus. Publication Status: Online-Only, [RefSeq, PubMed]; TRAF2 and TRAF3 were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in mature B cells., [RefSeq, PubMed]; TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway., [RefSeq, PubMed]; TRAF3IP3 contributes to marginal zone B cell survival by up-regulating autophagy, thereby promoting the T cell-independent type II immune response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BY50;Q8K1Y9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0044198 zf-TRAF domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0035457 cellular response to interferon-alpha;GO:0035458 cellular response to interferon-beta;GO:0032481 positive regulation of type I interferon production;GO:0032728 positive regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C0G2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N6-1", "uniprot_id": [ { "id": "SYT8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N6", "type": "external" } ], "mass": 44093.0, "length": 395, "protein_name": "Synaptotagmin-8", "gene_name": "Syt8", "organism": "Mouse", "refseq_name": "synaptotagmin-8 isoform b", "refseq_ac": [ { "id": "NP_001272786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272786", "type": "external" } ], "gene_names_uniprotkb": "Syt8", "gene_names_refseq": "Syt8", "protein_names_uniprotkb": "Synaptotagmin-8; Synaptotagmin VIII; SytVIII", "protein_names_refseq": "synaptotagmin-8 isoform b; synaptotagmin-8; sytVIII", "tax_id": 10090, "disease": "", "pathway": " (mmu:55925); (R-MMU-8856825); (R-MMU-8856828)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10531343;10734137;11011146;11751263;15774481;16386321;21750661;35820727;7791877;9575177", "class_list": "", "function": "Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Syt VIII is a candidate for the Ca(2+) sensor that regulates acrosomal exocytosis in mammalian sperm, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9JAL0;Q64366;Q8C6E7", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005544 calcium-dependent phospholipid binding;GO:0030276 clathrin binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0001669 acrosomal vesicle;GO:0031982 vesicle", "go_biological_process": "GO:0007340 acrosome reaction;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0N6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W52-1", "uniprot_id": [ { "id": "TMM19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W52", "type": "external" } ], "mass": 36296.0, "length": 336, "protein_name": "Transmembrane protein 19", "gene_name": "Tmem19", "organism": "Mouse", "refseq_name": "transmembrane protein 19 isoform 2", "refseq_ac": [ { "id": "NP_598444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598444", "type": "external" } ], "gene_names_uniprotkb": "Tmem19", "gene_names_refseq": "2810428F02Rik; Tmem19", "protein_names_uniprotkb": "Transmembrane protein 19", "protein_names_refseq": "transmembrane protein 19 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:67226)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;31219806;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UU09;Q8BY23;Q8BZK7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91W52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QZZ7-1", "uniprot_id": [ { "id": "TPRKB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8QZZ7", "type": "external" } ], "mass": 19556.0, "length": 175, "protein_name": "EKC/KEOPS complex subunit Tprkb", "gene_name": "Tprkb", "organism": "Mouse", "refseq_name": "EKC/KEOPS complex subunit Tprkb isoform a", "refseq_ac": [ { "id": "NP_001163959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163959", "type": "external" } ], "gene_names_uniprotkb": "Tprkb", "gene_names_refseq": "0610033G21Rik; 1810034M08Rik; Cgi-121; DRWMS1; Tprkb; mDRWMS1", "protein_names_uniprotkb": "EKC/KEOPS complex subunit Tprkb; PRPK-binding protein; TP53RK-binding protein", "protein_names_refseq": "EKC/KEOPS complex subunit Tprkb isoform a; EKC/KEOPS complex subunit Tprkb; PRPK-binding protein; Prpk (p53-related protein kinase)-binding protein; TP53RK-binding protein", "tax_id": 10090, "disease": "Galloway-Mowat syndrome 5 (Disease Ontology:DOID:0080247)", "pathway": " (mmu:69786)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;28805828", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QZZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLC6-1", "uniprot_id": [ { "id": "TEF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLC6", "type": "external" } ], "mass": 33145.0, "length": 301, "protein_name": "Thyrotroph embryonic factor", "gene_name": "Tef", "organism": "Mouse", "refseq_name": "thyrotroph embryonic factor isoform 1", "refseq_ac": [ { "id": "NP_059072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059072", "type": "external" } ], "gene_names_uniprotkb": "Tef", "gene_names_refseq": "2310028D20Rik; Tef", "protein_names_uniprotkb": "Thyrotroph embryonic factor", "protein_names_refseq": "thyrotroph embryonic factor isoform 1; thyrotrophic embryonic factor", "tax_id": 10090, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:21685)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10799536;14702338;15175240;21750661;30515906;8617210", "class_list": "", "function": "Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner., [UniProtKB]; Upregulation of TEF expression significantly retarded Bladder Cancer cell growth by inhibiting the G1/S transition via regulating AKT/FOXOs signalling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U426;Q3UGF4;Q3UM49;Q3URC8;Q6QHT6;Q8C6I0;Q8VD02", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JLC6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D845-1", "uniprot_id": [ { "id": "TEX9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D845", "type": "external" } ], "mass": 44066.0, "length": 387, "protein_name": "Testis-expressed protein 9", "gene_name": "Tex9", "organism": "Mouse", "refseq_name": "testis-expressed protein 9", "refseq_ac": [ { "id": "NP_033385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033385", "type": "external" } ], "gene_names_uniprotkb": "Tex9", "gene_names_refseq": "Gm19407; Tex9; tsec-1", "protein_names_uniprotkb": "Testis-expressed protein 9; Testis-specifically expressed protein 1; Tsec-1", "protein_names_refseq": "testis-expressed protein 9; testis-expressed sequence 9 protein; testis-specifically expressed protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21778)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;9388464", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RUA2;O54764", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D845-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCF1-1", "uniprot_id": [ { "id": "TMM25_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCF1", "type": "external" } ], "mass": 39170.0, "length": 365, "protein_name": "Transmembrane protein 25", "gene_name": "Tmem25", "organism": "Mouse", "refseq_name": "transmembrane protein 25 isoform b precursor", "refseq_ac": [ { "id": "NP_082141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082141", "type": "external" } ], "gene_names_uniprotkb": "Tmem25", "gene_names_refseq": "0610039J01Rik; Tmem25", "protein_names_uniprotkb": "Transmembrane protein 25", "protein_names_refseq": "transmembrane protein 25 isoform b precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:71687)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004;31424425;37095176", "class_list": "", "function": "In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability., [UniProtKB, PubMed]; TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; These results provide some insights into TMEM25 biology in the brain and the functional relationship between TMEM25 and epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3TMP3;Q6PAK7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome;GO:0016020 membrane", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0090394 negative regulation of excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9DCF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFU8-1", "uniprot_id": [ { "id": "T53I2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFU8", "type": "external" } ], "mass": 24288.0, "length": 221, "protein_name": "Tumor protein p53-inducible nuclear protein 2", "gene_name": "Tp53inp2; Trp53inp2", "organism": "Mouse", "refseq_name": "tumor protein p53-inducible nuclear protein 2 isoform a", "refseq_ac": [ { "id": "NP_835212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835212", "type": "external" } ], "gene_names_uniprotkb": "Tp53inp2; Trp53inp2; Dor; Trp53inp2", "gene_names_refseq": "1110029F20Rik; Tp53inp2; Trp53inp2", "protein_names_uniprotkb": "Tumor protein p53-inducible nuclear protein 2; Diabetes and obesity-regulated protein", "protein_names_refseq": "diabetes and obesity-regulated protein; tumor protein p53-inducible nuclear protein 2 isoform a; tumor protein p53-inducible nuclear protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68728)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18030323;21750661;24713655;38545813;38652010", "class_list": "", "function": "Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA., [UniProtKB, PubMed]; TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury., [RefSeq, PubMed]; TP53INP2 repression is part of an adaptive mechanism aimed at preserving muscle mass under conditions in which insulin action is deficient., [RefSeq, PubMed]; TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDL6;Q711P5;Q8CHM4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0016605 PML body", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CFU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZG4-1", "uniprot_id": [ { "id": "TAF3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5HZG4", "type": "external" } ], "mass": 105115.0, "length": 932, "protein_name": "Transcription initiation factor TFIID subunit 3", "gene_name": "Taf3", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 3", "refseq_ac": [ { "id": "NP_082024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082024", "type": "external" } ], "gene_names_uniprotkb": "Taf3", "gene_names_refseq": "140kDa; 4933439M23Rik; TAF140; TAFII-140; TAFII140; Taf3; mTAFII140", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 3; 140 kDa TATA box-binding protein-associated factor; TAF(II)140; TAF140; TAFII-140; TAFII140; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit", "protein_names_refseq": "140 kDa TATA box-binding protein-associated factor; RNA polymerase II transcription factor, TFIID subunit; TAF(II)140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; TBP-associated factor 3; transcription initiation factor TFIID 140 kDa subunit; transcription initiation factor TFIID subunit 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:209361); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "11438666;17704303;18682226;21183079;21750661;23806337;25866244;27802388;31219806", "class_list": "", "function": "Data indicate that TATA box binding protein-associated factor TAF3 as a direct target of nuclear phosphoinositides (PI)., [RefSeq, PubMed]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (By similarity). TAF3 forms the TFIID-A module together with TAF5 and TBP (By similarity). Required in complex with TBPL2 for the differentiation of myoblasts into myocytes (PubMed:17704303). The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process (PubMed:17704303)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U490;Q3UWX2;Q8BIU8;Q99JH4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0002039 p53 binding;GO:0140416 transcription regulator inhibitor activity;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5HZG4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMD6-1", "uniprot_id": [ { "id": "TM260_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMD6", "type": "external" } ], "mass": 78947.0, "length": 703, "protein_name": "Protein O-mannosyl-transferase TMEM260", "gene_name": "Tmem260", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase TMEM260 isoform 2", "refseq_ac": [ { "id": "NP_001297513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297513", "type": "external" } ], "gene_names_uniprotkb": "Tmem260; 6720456H20Rik", "gene_names_refseq": "5930435P15; 6720456H20Rik; Tmem260", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMEM260; 2.4.1.109; Transmembrane protein 260", "protein_names_refseq": "UPF0679 protein C14orf101 homolog; protein O-mannosyl-transferase TMEM260 isoform 2; protein O-mannosyl-transferase TMEM260", "tax_id": 10090, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (mmu:218989)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "18299400;21750661;21952136;25428506;30084848;30779550;31219806;31599954;34203471;34428180;35820727;37186866;40997131", "class_list": "", "function": "O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins. Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON. TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GT69;Q80SZ4;Q8BMG3;Q8BW28;Q8BYU4", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8BMD6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3F7-1", "uniprot_id": [ { "id": "TDH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K3F7", "type": "external" } ], "mass": 41462.0, "length": 373, "protein_name": "L-threonine 3-dehydrogenase, mitochondrial", "gene_name": "Tdh", "organism": "Mouse", "refseq_name": "L-threonine 3-dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_067455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067455", "type": "external" } ], "gene_names_uniprotkb": "Tdh", "gene_names_refseq": "Tdh", "protein_names_uniprotkb": "L-threonine 3-dehydrogenase, mitochondrial; 1.1.1.103", "protein_names_refseq": "L-threonine 3-dehydrogenase, mitochondrial precursor; L-threonine 3-dehydrogenase, mitochondrial", "tax_id": 10090, "disease": "", "pathway": " (mmu:58865)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12097150;21750661;21896756;25428506;26492815;28319092", "class_list": "", "function": "Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism., [UniProtKB, PubMed]; Data shsow that metabolic flux through the TDH pathway is required for the viability and self-renewal of ES cells., [RefSeq, PubMed]; TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PD91;Q9JLU3", "ec_number_list": [ { "id": "1.1.1.103", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.103", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008743 L-threonine 3-dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019518 L-threonine catabolic process to glycine;GO:0006567 L-threonine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K3F7-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61333-1", "uniprot_id": [ { "id": "TNAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61333", "type": "external" } ], "mass": 78102.0, "length": 691, "protein_name": "Tumor necrosis factor alpha-induced protein 2", "gene_name": "Tnfaip2", "organism": "Mouse", "refseq_name": "tumor necrosis factor alpha-induced protein 2", "refseq_ac": [ { "id": "NP_033422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033422", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip2", "gene_names_refseq": "B94; Exoc3l3; M-sec; Tnfaip2; Tnfip2; tnfb94", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 2; Primary response gene B94 protein; TNF alpha-induced protein 2", "protein_names_refseq": "TNF alpha-induced protein 2; primary response gene B94 protein; tumor necrosis factor alpha-induced protein 2; tumor necrosis factor induced protein 2", "tax_id": 10090, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (mmu:21928)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;34428180;36084515;37980507;8106408", "class_list": "", "function": "May play a role as a mediator of inflammation and angiogenesis., [UniProtKB, UniProtKB, UniProtKB]; Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice. Publication Status: Online-Only, [RefSeq, PubMed]; Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T9B0;Q3TCH9;Q922G1", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0000145 exocyst", "go_biological_process": "GO:0051601 exocyst localization;GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q61333-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXG9-1", "uniprot_id": [ { "id": "TINF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QXG9", "type": "external" } ], "mass": 37887.0, "length": 341, "protein_name": "TERF1-interacting nuclear factor 2", "gene_name": "Tinf2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tinf2; Tin2", "gene_names_refseq": "", "protein_names_uniprotkb": "TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "autosomal dominant dyskeratosis congenita 3 (Disease Ontology:DOID:0070018); Revesz syndrome (Disease Ontology:DOID:0070026); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (R-MMU-110330); (R-MMU-110331); (R-MMU-171319); (R-MMU-174411); (R-MMU-174414); (R-MMU-174417); (R-MMU-174430); (R-MMU-174437); (R-MMU-2559586); (R-MMU-9670095)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "19487455;21750661;30084848;31219806;34428180", "class_list": "", "function": "Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q126", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0010370 perinucleolar chromocenter;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000783 nuclear telomere cap complex;GO:0070187 shelterin complex", "go_biological_process": "GO:0032205 negative regulation of telomere maintenance;GO:1904356 regulation of telomere maintenance via telomere lengthening;GO:0050680 negative regulation of epithelial cell proliferation;GO:0016233 telomere capping;GO:0032202 telomere assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QXG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UNB8-1", "uniprot_id": [ { "id": "TM253_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UNB8", "type": "external" } ], "mass": 22415.0, "length": 204, "protein_name": "Transmembrane protein 253", "gene_name": "Tmem253", "organism": "Mouse", "refseq_name": "transmembrane protein 253", "refseq_ac": [ { "id": "NP_001028977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028977", "type": "external" } ], "gene_names_uniprotkb": "Tmem253", "gene_names_refseq": "G630016D24Rik; Tmem253", "protein_names_uniprotkb": "Transmembrane protein 253", "protein_names_refseq": "tranmembrane protein 253; transmembrane protein 253; transmembrane protein C14orf176 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:619301)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3UNB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG09-1", "uniprot_id": [ { "id": "T184B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG09", "type": "external" } ], "mass": 45589.0, "length": 407, "protein_name": "Transmembrane protein 184B", "gene_name": "Tmem184b", "organism": "Mouse", "refseq_name": "transmembrane protein 184B isoform 1", "refseq_ac": [ { "id": "NP_001240746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240746", "type": "external" } ], "gene_names_uniprotkb": "Tmem184b", "gene_names_refseq": "2610507A11; 4732495E13Rik; Tmem184b", "protein_names_uniprotkb": "Transmembrane protein 184B", "protein_names_refseq": "transmembrane protein 184B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:223693)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;25428506;34428180;36210013;37730546", "class_list": "", "function": "May activate the MAP kinase signaling pathway., [UniProtKB]; Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY97;Q8BJ02", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BG09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K304-1", "uniprot_id": [ { "id": "TM129_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K304", "type": "external" } ], "mass": 40628.0, "length": 362, "protein_name": "E3 ubiquitin-protein ligase TM129", "gene_name": "Tmem129", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TM129 isoform a", "refseq_ac": [ { "id": "NP_080974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080974", "type": "external" } ], "gene_names_uniprotkb": "Tmem129", "gene_names_refseq": "0610039G24Rik; 2410015J15Rik; Tmem129", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TM129; 2.3.2.27; RING-type E3 ubiquitin transferase TM129", "protein_names_refseq": "E3 ubiquitin-protein ligase TM129 isoform a; E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129", "tax_id": 10090, "disease": "", "pathway": " (mmu:68366)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TA74;Q9DCF3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein;GO:0030970 retrograde protein transport, ER to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K304-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCF2-1", "uniprot_id": [ { "id": "TPPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCF2", "type": "external" } ], "mass": 16882.0, "length": 145, "protein_name": "Trafficking protein particle complex subunit 1", "gene_name": "Trappc1", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_001019377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019377", "type": "external" } ], "gene_names_uniprotkb": "Trappc1", "gene_names_refseq": "BET5; D11Ertd172e; MUM2; Trappc1", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 1", "protein_names_refseq": "novel Sybindin-like family domain-containing protein; trafficking protein particle complex subunit 1 isoform 1; trafficking protein particle complex subunit 1", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909)", "pathway": " (mmu:245828); (R-MMU-204005); (R-MMU-6798695); (R-MMU-8876198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "21750661;31219806;34428180;36210013;36440617;38234007", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice., [RefSeq, PubMed]; Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5NCF2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1J1-1", "uniprot_id": [ { "id": "TM6S2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1J1", "type": "external" } ], "mass": 43027.0, "length": 378, "protein_name": "Transmembrane 6 superfamily member 2", "gene_name": "Tm6sf2", "organism": "Mouse", "refseq_name": "transmembrane 6 superfamily member 2 isoform 2", "refseq_ac": [ { "id": "NP_853518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853518", "type": "external" } ], "gene_names_uniprotkb": "Tm6sf2", "gene_names_refseq": "Tm6sf2", "protein_names_uniprotkb": "Transmembrane 6 superfamily member 2", "protein_names_refseq": "transmembrane 6 superfamily member 2 isoform 2", "tax_id": 10090, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:107770)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21750661;24531328;24633158;26774178;27013658;30084848;33638902;34428180;36139452", "class_list": "", "function": "Despite TM6SF2 being located in the endoplasmic reticulum and Golgi complex, the lipids that accumulate in its absence reside in lipid droplets., [RefSeq, PubMed]; Expression of TM6SF2 promoted cholesterol biosynthesis in hepatocytes., [RefSeq, PubMed]; Liver-Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer., [RefSeq, PubMed]; Myeloid TM6SF2 Deficiency Inhibits Atherosclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIG1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R1J1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER72-1", "uniprot_id": [ { "id": "SYCC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER72", "type": "external" } ], "mass": 94860.0, "length": 831, "protein_name": "Cysteine--tRNA ligase, cytoplasmic", "gene_name": "Cars1", "organism": "Mouse", "refseq_name": "cysteine--tRNA ligase, cytoplasmic isoform 2", "refseq_ac": [ { "id": "NP_001239522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239522", "type": "external" } ], "gene_names_uniprotkb": "Cars1; Cars", "gene_names_refseq": "CA3; Cars1; Cars", "protein_names_uniprotkb": "Cysteine--tRNA ligase, cytoplasmic; 6.1.1.16; CysRS; Cysteinyl-tRNA synthetase", "protein_names_refseq": "cysRS; cysteine--tRNA ligase, cytoplasmic isoform 2; cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (mmu:27267)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11063728;21183079;21750661;25428506;28528544;30084848;30779550;34428180;35820727;37828378", "class_list": "", "function": "Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88303;Q8BP81;Q8CAY7;Q8CCE3;Q8K0S4;Q9ER68", "ec_number_list": [ { "id": "6.1.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.16", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006423 cysteinyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9ER72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMA2-1", "uniprot_id": [ { "id": "TGT_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JMA2", "type": "external" } ], "mass": 44093.0, "length": 403, "protein_name": "Queuine tRNA-ribosyltransferase catalytic subunit 1", "gene_name": "Qtrt1", "organism": "Mouse", "refseq_name": "queuine tRNA-ribosyltransferase catalytic subunit 1", "refseq_ac": [ { "id": "NP_068688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068688", "type": "external" } ], "gene_names_uniprotkb": "Qtrt1; Tgt; Tgut", "gene_names_refseq": "2610028E17Rik; Qtrt1; Tgt", "protein_names_uniprotkb": "Queuine tRNA-ribosyltransferase catalytic subunit 1; 2.4.2.64; Guanine insertion enzyme; tRNA-guanine transglycosylase", "protein_names_refseq": "guanine insertion enzyme; queuine tRNA-ribosyltransferase 1; queuine tRNA-ribosyltransferase catalytic subunit 1; tRNA-guanine transglycosylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:60507)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19414587;21750661;29862811;31219806;35815944;37609797", "class_list": "", "function": "Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:19414587, PubMed:29862811, PubMed:35815944, PubMed:37609797). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Modification of cytoplasmic tRNAs with queuosine controls the elongation speed of cognate codons, thereby ensuring the correct folding of nascent proteins to maintain proteome integrity (PubMed:37609797)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed, PubMed]; Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80VS3", "ec_number_list": [ { "id": "2.4.2.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.64", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex;GO:0032473 cytoplasmic side of mitochondrial outer membrane", "go_biological_process": "GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JMA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08351-1", "uniprot_id": [ { "id": "TPOR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08351", "type": "external" } ], "mass": 69788.0, "length": 625, "protein_name": "Thrombopoietin receptor", "gene_name": "Mpl", "organism": "Mouse", "refseq_name": "thrombopoietin receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_001116421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116421", "type": "external" } ], "gene_names_uniprotkb": "Mpl; Tpor", "gene_names_refseq": "CD110; Mpl; TPO-R; c-mpl; hlb219", "protein_names_uniprotkb": "Thrombopoietin receptor; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; TPO-R", "protein_names_refseq": "myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; proto-oncogene c-Mpl; thrombopoietin receptor isoform 1 precursor; thrombopoietin receptor", "tax_id": 10090, "disease": "congenital amegakaryocytic thrombocytopenia 1 (Disease Ontology:DOID:0061005); congenital amegakaryocytic thrombocytopenia (Disease Ontology:DOID:0090118); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); myelofibrosis (Disease Ontology:DOID:4971); myeloid leukemia (Disease Ontology:DOID:8692)", "pathway": " (mmu:17480)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11997107;15210714;21750661;22284746;25468569;38326297;38336176;38491305;8334987;8397366;8630375;9122198;9639492", "class_list": "", "function": "Acts as an inhibitor of thrombopoietin signaling by promoting protein down-regulation of full-length isoform Mpl-fl., [UniProtKB, PubMed]; Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease., [RefSeq, PubMed]; Mpl-II isoform cloning, base sequence, and amino acid sequence - lacks a 60 amino acid region required for surface expression of the protein, [RefSeq, PubMed]; Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation (PubMed:8630375, PubMed:9122198, PubMed:9639492). Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Spatiotemporal expression profiles of c-Mpl mRNA in the tooth germ: Comparative expression dynamics of vascularization-related genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 1, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 1, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 1, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A6H8H6;Q8BRX0", "ec_number_list": [], "go_molecular_function": "GO:0038164 thrombopoietin receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0032642 regulation of chemokine production;GO:0043066 negative regulation of apoptotic process;GO:0030220 platelet formation;GO:0072091 regulation of stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q08351-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1010000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52912-1", "uniprot_id": [ { "id": "TIA1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52912", "type": "external" } ], "mass": 42800.0, "length": 386, "protein_name": "Cytotoxic granule associated RNA binding protein TIA1", "gene_name": "Tia1", "organism": "Mouse", "refseq_name": "cytotoxic granule associated RNA binding protein TIA1 isoform 1", "refseq_ac": [ { "id": "NP_035715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035715", "type": "external" } ], "gene_names_uniprotkb": "Tia1; Tia", "gene_names_refseq": "2310050N03Rik; TIA-1; Tia1; mTIA-1", "protein_names_uniprotkb": "Cytotoxic granule associated RNA binding protein TIA1; Nucleolysin TIA-1; RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1", "protein_names_refseq": "RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; cytotoxic granule associated RNA binding protein TIA1 isoform 1; cytotoxic granule associated RNA binding protein TIA1; nucleolysin TIA-1", "tax_id": 10090, "disease": "amyotrophic lateral sclerosis type 26 (Disease Ontology:DOID:0081380); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (mmu:21841)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10921895;10938105;11514562;16227602;16278295;18500819;21750661;29298433;34428180;37474714;8759725;8871565", "class_list": "", "function": "RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:10938105, PubMed:16227602). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:10938105). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (PubMed:10938105). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:10938105). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (By similarity). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (PubMed:11514562). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (By similarity). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (By similarity). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (By similarity). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (By similarity). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (PubMed:10921895, PubMed:16227602). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (By similarity). Formation and recruitment to SGs is regulated by Zn(2+) (PubMed:29298433). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The RNA binding proteins TIA1 and TIAL1 promote Mcl1 mRNA translation to protect germinal center responses from apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140517 protein-RNA adaptor activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0006397 mRNA processing;GO:0006915 apoptotic process;GO:0008380 RNA splicing;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P52912-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921Z5-1", "uniprot_id": [ { "id": "TFIP8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921Z5", "type": "external" } ], "mass": 22960.0, "length": 198, "protein_name": "Tumor necrosis factor alpha-induced protein 8", "gene_name": "Tnfaip8", "organism": "Mouse", "refseq_name": "tumor necrosis factor alpha-induced protein 8 isoform 3", "refseq_ac": [ { "id": "NP_001171231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171231", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip8", "gene_names_refseq": "E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2; Tipe; Tnfaip8", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8", "protein_names_refseq": "TNF alpha-induced protein 8; TNF-induced protein; tumor necrosis factor alpha-induced protein 8 isoform 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:106869); (R-MMU-1483255)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19730441;20607800;21750661;30084848;33921306;34428180;34608264;35387985", "class_list": "", "function": "Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity)., [UniProtKB]; Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation., [RefSeq, PubMed]; Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8., [RefSeq, PubMed]; TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQS5;Q3U9V7;Q3UBG8;Q8BTH4", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0050830 defense response to Gram-positive bacterium;GO:0006915 apoptotic process;GO:1902531 regulation of intracellular signal transduction;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q921Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ69-1", "uniprot_id": [ { "id": "TMC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQ69", "type": "external" } ], "mass": 128691.0, "length": 1130, "protein_name": "Transmembrane channel-like protein 3", "gene_name": "Tmc3", "organism": "Mouse", "refseq_name": "transmembrane channel-like protein 3", "refseq_ac": [ { "id": "NP_808363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808363", "type": "external" } ], "gene_names_uniprotkb": "Tmc3", "gene_names_refseq": "9030203A06; Tmc3", "protein_names_uniprotkb": "Transmembrane channel-like protein 3", "protein_names_refseq": "transmembrane channel-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:233424)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12812529;12906855;21750661;25428506;34428180;35820727", "class_list": "", "function": "Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN63", "ec_number_list": [], "go_molecular_function": "GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TQ69-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH32-1", "uniprot_id": [ { "id": "SUSD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH32", "type": "external" } ], "mass": 53797.0, "length": 490, "protein_name": "Sushi domain-containing protein 4", "gene_name": "Susd4", "organism": "Mouse", "refseq_name": "sushi domain-containing protein 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_659045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659045", "type": "external" } ], "gene_names_uniprotkb": "Susd4", "gene_names_refseq": "E430021N18Rik; Susd4", "protein_names_uniprotkb": "Sushi domain-containing protein 4", "protein_names_refseq": "sushi domain-containing protein 4 isoform 1 precursor; sushi domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:96935)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;20348246;21750661;30899004;33661101", "class_list": "", "function": "Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways., [UniProtKB, UniProtKB, PubMed]; Analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4, [RefSeq, PubMed]; Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VC43", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098688 parallel fiber to Purkinje cell synapse;GO:0016020 membrane", "go_biological_process": "GO:0045959 negative regulation of complement activation, classical pathway;GO:0045957 negative regulation of complement activation, alternative pathway;GO:0030449 regulation of complement activation;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BH32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N80-1", "uniprot_id": [ { "id": "SYTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N80", "type": "external" } ], "mass": 62362.0, "length": 567, "protein_name": "Synaptotagmin-like protein 1", "gene_name": "Sytl1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sytl1; Slp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptotagmin-like protein 1; Exophilin-7", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:269589); (R-MMU-8854214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11243866;11773082;18266782;21183079;21750661;34428180", "class_list": "", "function": "Binds phosphatidylinositol 3,4,5-trisphosphate (By similarity). May play a role in vesicle trafficking. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99J26", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0042470 melanosome;GO:0070382 exocytic vesicle;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99N80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UES3-1", "uniprot_id": [ { "id": "TNKS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UES3", "type": "external" } ], "mass": 126744.0, "length": 1166, "protein_name": "Poly [ADP-ribose] polymerase tankyrase-2", "gene_name": "Tnks2", "organism": "Mouse", "refseq_name": "poly [ADP-ribose] polymerase tankyrase-2", "refseq_ac": [ { "id": "NP_001157107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157107", "type": "external" } ], "gene_names_uniprotkb": "Tnks2; Tank2", "gene_names_refseq": "5430432P15Rik; ARTD6; Parp5b; TNKS-2; Tank2; Tnks2", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase tankyrase-2; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-2", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 6; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase tankyrase-2; protein poly-ADP-ribosyltransferase tankyrase-2; tankyrase II; tankyrase-2; tankyrase-like protein; tankyrase-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:74493); (R-MMU-201681); (R-MMU-4641257); (R-MMU-5689880); (R-MMU-8948751)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "16507984;16507985;18612384;20549720;21750661;22153076;32442396;34428180", "class_list": "", "function": "Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt ligands., [RefSeq, PubMed]; Developmentally Programmed Tankyrase Activity Upregulates beta-Catenin and Licenses Progression of Embryonic Genome Activation., [RefSeq, PubMed]; Inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism., [RefSeq, PubMed]; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity., [UniProtKB, UniProtKB]; Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction., [RefSeq, PubMed]; Tankyrase 2is essential but redundant for mouse embryonic development Publication Status: Online-Only, [RefSeq, PubMed]; Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P537;Q8BXH7", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0040014 regulation of multicellular organism growth;GO:0035264 multicellular organism growth;GO:0000723 telomere maintenance;GO:0070198 protein localization to chromosome, telomeric region", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3UES3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C1Z8-1", "uniprot_id": [ { "id": "TM10A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C1Z8", "type": "external" } ], "mass": 37966.0, "length": 328, "protein_name": "tRNA methyltransferase 10 homolog A", "gene_name": "Trmt10a", "organism": "Mouse", "refseq_name": "tRNA methyltransferase 10 homolog A isoform 1", "refseq_ac": [ { "id": "NP_001335125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335125", "type": "external" } ], "gene_names_uniprotkb": "Trmt10a; Rg9mtd2", "gene_names_refseq": "3110023L08Rik; Rg9mtd2; Rnmtd2; Trmt10a", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog A; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10A; tRNA methyltransferase 10 homolog A isoform 1; tRNA methyltransferase 10 homolog A", "tax_id": 10090, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (mmu:108943)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KMM8;Q5CZW9;Q8VDF5", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0030488 tRNA methylation;GO:0010960 magnesium ion homeostasis;GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C1Z8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DN89-1", "uniprot_id": [ { "id": "TM254_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DN89", "type": "external" } ], "mass": 14239.0, "length": 123, "protein_name": "Transmembrane protein 254", "gene_name": "Tmem254", "organism": "Mouse", "refseq_name": "transmembrane protein 254 isoform 2", "refseq_ac": [ { "id": "NP_079587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079587", "type": "external" } ], "gene_names_uniprotkb": "Tmem254; D14Ertd449e; Tmem254a; Tmem254b; Tmem254c", "gene_names_refseq": "0610008K04Rik; 0610010A22Rik; D14Ertd449e; Gm10395; Gm9746; Tmem254a; Tmem254b; Tmem254c; Tmem254", "protein_names_uniprotkb": "Transmembrane protein 254", "protein_names_refseq": "tranmembrane protein 254a; transmembrane protein 254 isoform 2; transmembrane protein 254a; transmembrane protein 254b; transmembrane protein 254c; transmembrane protein C10orf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66039)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F6V0T5;P0DN90;P0DN91;Q9D890;Q9DCV5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0DN89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40226-1", "uniprot_id": [ { "id": "TPO_MOUSE", "url": "https://www.uniprot.org/uniprot/P40226", "type": "external" } ], "mass": 37836.0, "length": 356, "protein_name": "Thrombopoietin", "gene_name": "Thpo", "organism": "Mouse", "refseq_name": "thrombopoietin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001166976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166976", "type": "external" } ], "gene_names_uniprotkb": "Thpo", "gene_names_refseq": "Mgdf; Ml; Mpllg; Thpo; Tpo", "protein_names_uniprotkb": "Thrombopoietin; C-mpl ligand; MGDF; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Myeloproliferative leukemia virus oncogene ligand", "protein_names_refseq": "C-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand; thrombopoietin isoform 1 precursor", "tax_id": 10090, "disease": "congenital amegakaryocytic thrombocytopenia 2 (Disease Ontology:DOID:0061002); aplastic anemia (Disease Ontology:DOID:12449); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); liver cirrhosis (Disease Ontology:DOID:5082); arteriosclerosis obliterans (Disease Ontology:DOID:5160); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:21832)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22284746;7849319;8020099;8202158", "class_list": "", "function": "Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0001934 positive regulation of protein phosphorylation;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40226-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60774-1", "uniprot_id": [ { "id": "TM45A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60774", "type": "external" } ], "mass": 31343.0, "length": 273, "protein_name": "Transmembrane protein 45A", "gene_name": "Tmem45a", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem45a; Derp7", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 45A; 19.5; Dermal papilla-derived protein 7 homolog", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1980600;21750661;31599954;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q60774-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIQ8-1", "uniprot_id": [ { "id": "TMPS2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIQ8", "type": "external" } ], "mass": 53526.0, "length": 490, "protein_name": "Transmembrane protease serine 2", "gene_name": "Tmprss2", "organism": "Mouse", "refseq_name": "transmembrane protease serine 2", "refseq_ac": [ { "id": "NP_056590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056590", "type": "external" } ], "gene_names_uniprotkb": "Tmprss2", "gene_names_refseq": "D16Ertd61e; Tmprss2", "protein_names_uniprotkb": "Transmembrane protease serine 2; 3.4.21.122; Epitheliasin; Plasmic transmembrane protein X", "protein_names_refseq": "epitheliasin; plasmic transmembrane protein X; transmembrane protease serine 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50528)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10683448;11169526;16428450;21750661;24348248;24522916;24600012;25734995", "class_list": "", "function": "(Microbial infection) Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9) and is involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity., [UniProtKB, PubMed, PubMed, PubMed]; Plasma membrane-anchored serine protease that cleaves at arginine residues (By similarity). Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption (By similarity). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (PubMed:25734995)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN04;Q9JKC4;Q9QY82", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0046598 positive regulation of viral entry into host cell;GO:0016540 protein autoprocessing;GO:0098670 entry receptor-mediated virion attachment to host cell", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JIQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0P4-1", "uniprot_id": [ { "id": "SMAP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0P4", "type": "external" } ], "mass": 20046.0, "length": 181, "protein_name": "Small acidic protein", "gene_name": "1110004F10Rik; Smap", "organism": "Mouse", "refseq_name": "small acidic protein isoform 1", "refseq_ac": [ { "id": "NP_062746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062746", "type": "external" } ], "gene_names_uniprotkb": "1110004F10Rik; Smap; Sid2057", "gene_names_refseq": "1110004F10Rik; Smacp; Smap; sid2057p; sid2057", "protein_names_uniprotkb": "Small acidic protein; Sid 2057", "protein_names_refseq": "sid 2057; small acidic protein isoform 1; small acidic protein sid2057p", "tax_id": 10090, "disease": "", "pathway": " (mmu:56372)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15345747;17242355;18630941;21183079;21750661;26495903;28528544;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9R0P4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIW5-1", "uniprot_id": [ { "id": "SMAD9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JIW5", "type": "external" } ], "mass": 48636.0, "length": 430, "protein_name": "SMAD family member 9", "gene_name": "Smad9", "organism": "Mouse", "refseq_name": "SMAD family member 9", "refseq_ac": [ { "id": "NP_062356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062356", "type": "external" } ], "gene_names_uniprotkb": "Smad9; Madh8; Madh9; Smad8", "gene_names_refseq": "MADH6; Madh8; Madh9; Smad8; Smad9", "protein_names_uniprotkb": "SMAD family member 9; MAD homolog 9; Mothers against DPP homolog 9; Mothers against decapentaplegic homolog 9; SMAD 9", "protein_names_refseq": "MAD homolog 9; SMAD family member 9; mothers against DPP homolog 9; mothers against decapentaplegic homolog 9", "tax_id": 10090, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate cancer (Disease Ontology:DOID:10283); primary pulmonary hypertension (Disease Ontology:DOID:14557); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:55994); (R-MMU-201451)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10814522;11163184;11850197;15542835;19419974", "class_list": "", "function": "Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney., [RefSeq, PubMed]; Smad8 loss of function resulted in changes in pulmonary arteries including medial thickening and smooth muscle hyperplasia observed in patients with pulmonary artery hypertension., [RefSeq, PubMed]; This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]., [RefSeq]; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFF9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JIW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJX8-1", "uniprot_id": [ { "id": "ST32B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJX8", "type": "external" } ], "mass": 47916.0, "length": 414, "protein_name": "Serine/threonine-protein kinase 32B", "gene_name": "Stk32b", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase 32B", "refseq_ac": [ { "id": "NP_071861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071861", "type": "external" } ], "gene_names_uniprotkb": "Stk32b; Stk32", "gene_names_refseq": "2510009F08Rik; STKG6; Stk32b; Stk32; YANK2", "protein_names_uniprotkb": "Serine/threonine-protein kinase 32B; 2.7.11.1", "protein_names_refseq": "serine threonine kinase 32; serine/threonine-protein kinase 32B", "tax_id": 10090, "disease": "", "pathway": " (mmu:64293)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10700184", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMD3;Q8C4E0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTP2-1", "uniprot_id": [ { "id": "SPY4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTP2", "type": "external" } ], "mass": 32523.0, "length": 300, "protein_name": "Protein sprouty homolog 4", "gene_name": "Spry4", "organism": "Mouse", "refseq_name": "protein sprouty homolog 4", "refseq_ac": [ { "id": "NP_036028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036028", "type": "external" } ], "gene_names_uniprotkb": "Spry4", "gene_names_refseq": "A030006O18Rik; Spry4; sprouty4", "protein_names_uniprotkb": "Protein sprouty homolog 4; Spry-4", "protein_names_refseq": "protein sprouty homolog 4", "tax_id": 10090, "disease": "hypogonadotropic hypogonadism 17 with or without anosmia (Disease Ontology:DOID:0090079)", "pathway": " (mmu:24066)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10330503;10498682;16877379;17974561;39174793", "class_list": "", "function": "Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Publication Status: Online-Only, [RefSeq, PubMed]; Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q543R1;Q9QXV7", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032587 ruffle membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:1990830 cellular response to leukemia inhibitory factor;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0043407 negative regulation of MAP kinase activity;GO:1900025 negative regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WTP2-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUA2-1", "uniprot_id": [ { "id": "SYFB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUA2", "type": "external" } ], "mass": 65697.0, "length": 589, "protein_name": "Phenylalanine--tRNA ligase beta subunit", "gene_name": "Farsb", "organism": "Mouse", "refseq_name": "phenylalanine--tRNA ligase beta subunit isoform 1", "refseq_ac": [ { "id": "NP_001265004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265004", "type": "external" } ], "gene_names_uniprotkb": "Farsb; Farslb; Farsl; Frsb", "gene_names_refseq": "Farsa; Farsb; Farslb; Farsl; Frsb", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase beta subunit; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase beta subunit", "protein_names_refseq": "PheRS alpha; phenylalanine tRNA synthetase alpha; phenylalanine--tRNA ligase beta chain; phenylalanine--tRNA ligase beta subunit isoform 1; phenylalanine--tRNA ligase beta subunit; phenylalanine-tRNA synthetase-like, beta subunit; phenylalanyl-tRNA synthetase beta chain", "tax_id": 10090, "disease": "", "pathway": " (mmu:23874)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10375616;21750661;25428506;30084848;30779550;34428180;35820727;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWZ8", "ec_number_list": [ { "id": "6.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004826 phenylalanine-tRNA ligase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0009328 phenylalanine-tRNA ligase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0051290 protein heterotetramerization;GO:0006432 phenylalanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9WUA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEA7-1", "uniprot_id": [ { "id": "TCTA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEA7", "type": "external" } ], "mass": 13297.0, "length": 122, "protein_name": "T-cell leukemia translocation-altered gene protein homolog", "gene_name": "Tcta", "organism": "Mouse", "refseq_name": "T-cell leukemia translocation-altered gene protein homolog isoform 1", "refseq_ac": [ { "id": "NP_598747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598747", "type": "external" } ], "gene_names_uniprotkb": "Tcta", "gene_names_refseq": "9130410M22Rik; Tctal; Tcta", "protein_names_uniprotkb": "T-cell leukemia translocation-altered gene protein homolog", "protein_names_refseq": "T-cell leukemia translocation altered; T-cell leukemia translocation-altered gene protein homolog isoform 1; T-cell leukemia translocation-altered gene protein homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:102791)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16479539;19560569;21750661;31219806;34428180", "class_list": "", "function": "May be required for cellular fusion during osteoclastogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045671 negative regulation of osteoclast differentiation;GO:0072675 osteoclast fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VEA7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97357-1", "uniprot_id": [ { "id": "TAF1A_MOUSE", "url": "https://www.uniprot.org/uniprot/P97357", "type": "external" } ], "mass": 52718.0, "length": 453, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit A", "gene_name": "Taf1a", "organism": "Mouse", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2", "refseq_ac": [ { "id": "NP_001264886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264886", "type": "external" } ], "gene_names_uniprotkb": "Taf1a", "gene_names_refseq": "TAFI48; Taf1a; mTAFI48", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit A; RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription initiation factor SL1/TIF-IB subunit A", "protein_names_refseq": "RNA polymerase I-specific TBP-associated factor 48 kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A; TATA box-binding protein-associated factor 1A; TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2; TATA box-binding protein-associated factor RNA polymerase I subunit A; TBP-associated factor 1A; transcription initiation factor SL1/TIF-IB subunit A", "tax_id": 10090, "disease": "", "pathway": " (mmu:21339); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21750661;9050847", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm;GO:0015630 microtubule cytoskeleton;GO:0000120 RNA polymerase I transcription regulator complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97357-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35536-1", "uniprot_id": [ { "id": "TFPI2_MOUSE", "url": "https://www.uniprot.org/uniprot/O35536", "type": "external" } ], "mass": 26137.0, "length": 230, "protein_name": "Tissue factor pathway inhibitor 2", "gene_name": "Tfpi2", "organism": "Mouse", "refseq_name": "tissue factor pathway inhibitor 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033390", "type": "external" } ], "gene_names_uniprotkb": "Tfpi2", "gene_names_refseq": "PP5/TFPI-2; Tfpi2", "protein_names_uniprotkb": "Tissue factor pathway inhibitor 2; TFPI-2", "protein_names_refseq": "tissue factor pathway inhibitor 2 isoform 1 precursor", "tax_id": 10090, "disease": "retinal degeneration (Disease Ontology:DOID:8466); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:21789)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10669168;12921785;21750661;30254643;35157852;39154703;8945635", "class_list": "", "function": "Bovine TFPI2 was compared to mouse TFPI2., [RefSeq, PubMed]; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (By similarity)., [UniProtKB]; Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer., [RefSeq, PubMed]; TFPI-2 Protects Against Gram-Negative Bacterial Infection. Publication Status: Online-Only, [RefSeq, PubMed]; TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35536-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20352-1", "uniprot_id": [ { "id": "TF_MOUSE", "url": "https://www.uniprot.org/uniprot/P20352", "type": "external" } ], "mass": 32935.0, "length": 294, "protein_name": "Tissue factor", "gene_name": "F3", "organism": "Mouse", "refseq_name": "tissue factor precursor", "refseq_ac": [ { "id": "NP_034301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034301", "type": "external" } ], "gene_names_uniprotkb": "F3; Cf-3; Cf3", "gene_names_refseq": "CD142; Cf-3; Cf3; F3; TF", "protein_names_uniprotkb": "Tissue factor; Coagulation factor III; TF", "protein_names_refseq": "coagulation factor III; tissue factor precursor; tissue factor", "tax_id": 10090, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); COVID-19 (Disease Ontology:DOID:0080600); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); von Willebrand's disease (Disease Ontology:DOID:12531); acute pancreatitis (Disease Ontology:DOID:2913); carotid artery thrombosis (Disease Ontology:DOID:3410); bile duct disease (Disease Ontology:DOID:4138); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:14066); (R-MMU-9769735); (R-MMU-9769739)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;19656770;1985911;21750661;23291174;25428506;2761539;35820727;38641310", "class_list": "", "function": "Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-beta positive feedback loop that promotes tumor progression and EMT in osteosarcoma., [RefSeq, PubMed]; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a membrane-bound glycoprotein that forms the primary physiological initiator of the blood coagulation process following vascular damage. The encoded protein binds to coagulation factor VIIa and the ensuing complex catalyzes the proteolytic activation of coagulation factors IX and X. Mice lacking encoded protein die in utero resulting from massive hemorrhaging in both extraembryonic and embryonic vessels. A severe deficiency of the encoded protein in mice results in impaired uterine homeostasis, shorter life spans due to spontaneous fatal hemorrhages and cardiac fibrosis. [provided by RefSeq, Aug 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 2, "disease_count": 27, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0004896 cytokine receptor activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0016485 protein processing;GO:0007596 blood coagulation;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P20352-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88393-1", "uniprot_id": [ { "id": "TGBR3_MOUSE", "url": "https://www.uniprot.org/uniprot/O88393", "type": "external" } ], "mass": 93829.0, "length": 850, "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "Tgfbr3", "organism": "Mouse", "refseq_name": "transforming growth factor beta receptor type 3 precursor", "refseq_ac": [ { "id": "NP_035708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035708", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr3", "gene_names_refseq": "1110036H20Rik; TBRIII; Tgfbr3", "protein_names_uniprotkb": "Transforming growth factor beta receptor type 3; Betaglycan; TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; Transforming growth factor beta receptor III", "protein_names_refseq": "TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; betaglycan; transforming growth factor beta receptor type 3 precursor; transforming growth factor beta receptor type 3", "tax_id": 10090, "disease": "endometrial adenocarcinoma (Disease Ontology:DOID:2870)", "pathway": " (mmu:21814); (R-MMU-1502540); (R-MMU-190370); (R-MMU-190373); (R-MMU-201451); (R-MMU-2173789); (R-MMU-9839383); (R-MMU-9839389); (R-MMU-9839397); (R-MMU-9839406)", "pathway_count": 10, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17704211;21750661;21871877;22033038;23826237;30364975;34910520;36855628;37828378;9659379", "class_list": "glycogene", "function": "Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (PubMed:30364975, PubMed:34910520). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (By similarity). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 39, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS72", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008201 heparin binding;GO:0015026 coreceptor activity;GO:0005160 transforming growth factor beta receptor binding;GO:0005024 transforming growth factor beta receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0010633 negative regulation of epithelial cell migration;GO:0060318 definitive erythrocyte differentiation;GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88393-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000010001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0N5-1", "uniprot_id": [ { "id": "SYT5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0N5", "type": "external" } ], "mass": 43130.0, "length": 386, "protein_name": "Synaptotagmin-5", "gene_name": "Syt5", "organism": "Mouse", "refseq_name": "synaptotagmin-5", "refseq_ac": [ { "id": "NP_001347350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001347350", "type": "external" } ], "gene_names_uniprotkb": "Syt5; Syt9", "gene_names_refseq": "Syt5; SytV", "protein_names_uniprotkb": "Synaptotagmin-5; Synaptotagmin IX; Synaptotagmin V; SytV", "protein_names_refseq": "synaptotagmin IX; synaptotagmin-5", "tax_id": 10090, "disease": "congenital myasthenic syndrome 7 (Disease Ontology:DOID:0110659); congenital myasthenic syndrome (Disease Ontology:DOID:3635); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (mmu:53420)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10531343;11751925;21750661;34428180", "class_list": "", "function": "May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R0N5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WQ5-1", "uniprot_id": [ { "id": "TAF5L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WQ5", "type": "external" } ], "mass": 65911.0, "length": 589, "protein_name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L", "gene_name": "Taf5l", "organism": "Mouse", "refseq_name": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L", "refseq_ac": [ { "id": "NP_598727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598727", "type": "external" } ], "gene_names_uniprotkb": "Taf5l; Paf65b", "gene_names_refseq": "1110005N04Rik; Taf5l", "protein_names_uniprotkb": "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; PAF65-beta; PCAF-associated factor 65 beta; TAF5L", "protein_names_refseq": "PAF65-beta; PCAF-associated factor 65 beta; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor", "tax_id": 10090, "disease": "", "pathway": " (mmu:102162)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21750661;22872234;25428506;30084848;31005419;31219806;34203471", "class_list": "", "function": "Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (PubMed:31005419)., [UniProtKB, UniProtKB, PubMed]; TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTL5", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0000124 SAGA complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91WQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C817-1", "uniprot_id": [ { "id": "T200A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C817", "type": "external" } ], "mass": 54008.0, "length": 491, "protein_name": "Transmembrane protein 200A", "gene_name": "Tmem200a", "organism": "Mouse", "refseq_name": "transmembrane protein 200A", "refseq_ac": [ { "id": "NP_084157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084157", "type": "external" } ], "gene_names_uniprotkb": "Tmem200a; Kiaa1913", "gene_names_refseq": "C030003D03Rik; Tmem200a", "protein_names_uniprotkb": "Transmembrane protein 200A", "protein_names_refseq": "transmembrane protein 200A", "tax_id": 10090, "disease": "", "pathway": " (mmu:77220)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;15345747;20485683;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q69Z67;Q8CCL5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8C817-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48428-1", "uniprot_id": [ { "id": "TBCA_MOUSE", "url": "https://www.uniprot.org/uniprot/P48428", "type": "external" } ], "mass": 12758.0, "length": 108, "protein_name": "Tubulin-specific chaperone A", "gene_name": "Tbca", "organism": "Mouse", "refseq_name": "tubulin-specific chaperone A", "refseq_ac": [ { "id": "NP_033347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033347", "type": "external" } ], "gene_names_uniprotkb": "Tbca", "gene_names_refseq": "Tbca13; Tbca", "protein_names_uniprotkb": "Tubulin-specific chaperone A; CFA; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A", "protein_names_refseq": "CFA; TCP1-chaperonin cofactor A; co-chaperonin associated with a- & b-tubulin; tubulin-folding cofactor A; tubulin-specific chaperone A", "tax_id": 10090, "disease": "", "pathway": " (mmu:21371)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11801660;16075062;21750661;22880023;32152506;36288343;7910827", "class_list": "", "function": "Tbca13 mRNA levels are post-transcriptionally regulated by the sense and natural antisense Tbca16 mRNA levels., [RefSeq, PubMed]; Tubulin-folding protein; involved in the early step of the tubulin folding pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48428-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3USQ7-1", "uniprot_id": [ { "id": "SYN1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3USQ7", "type": "external" } ], "mass": 25524.0, "length": 237, "protein_name": "Synapse differentiation-inducing gene protein 1-like", "gene_name": "Syndig1l", "organism": "Mouse", "refseq_name": "synapse differentiation-inducing gene protein 1-like", "refseq_ac": [ { "id": "NP_001028506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028506", "type": "external" } ], "gene_names_uniprotkb": "Syndig1l; Gm261; SynDIG2; Tmem90a", "gene_names_refseq": "DSPC1; Gm261; SynDIG2; Syndig1l; Tmem90a", "protein_names_uniprotkb": "Synapse differentiation-inducing gene protein 1-like; Capucin; Caudate and putamen-enriched protein; DSPC1; Dispanin subfamily C member 1; Synapse differentiation-induced protein 2; Transmembrane protein 90A", "protein_names_refseq": "capucin; caudate and putamen-enriched protein; dispanin subfamily C member 1; synapse differentiation-induced protein 2; synapse differentiation-inducing gene protein 1-like; transmembrane protein 90a", "tax_id": 10090, "disease": "", "pathway": " (mmu:627191)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16359841;21750661;22363774", "class_list": "", "function": "Significant down-regulation of capucin mRNA levels in two rodent models of Huntington disease, indicating a possible contribution to the pathogenesis of this disorder, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3USQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHH9-1", "uniprot_id": [ { "id": "T179A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHH9", "type": "external" } ], "mass": 26463.0, "length": 233, "protein_name": "Transmembrane protein 179", "gene_name": "Tmem179", "organism": "Mouse", "refseq_name": "transmembrane protein 179", "refseq_ac": [ { "id": "NP_849246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849246", "type": "external" } ], "gene_names_uniprotkb": "Tmem179", "gene_names_refseq": "Tmem179", "protein_names_uniprotkb": "Transmembrane protein 179", "protein_names_refseq": "transmembrane protein 179", "tax_id": 10090, "disease": "", "pathway": " (mmu:104885)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q78GD2;Q7TPP8;Q8BN09", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BHH9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AF53-1", "uniprot_id": [ { "id": "T185A_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AF53", "type": "external" } ], "mass": 40620.0, "length": 350, "protein_name": "Transmembrane protein 185A", "gene_name": "Tmem185a", "organism": "Mouse", "refseq_name": "transmembrane protein 185A isoform 1", "refseq_ac": [ { "id": "NP_001344679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001344679", "type": "external" } ], "gene_names_uniprotkb": "Tmem185a; Ee3; Fam11a", "gene_names_refseq": "Tmem185a; ee3", "protein_names_uniprotkb": "Transmembrane protein 185A; Erythropoietin-induced EST 3; Protein FAM11A", "protein_names_refseq": "erythropoietin-induced EST 3; transmembrane protein 185A isoform 1", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15525354", "class_list": "", "function": "The mouse ee3 is an orphan G-protein-coupled receptor with potential connections to erythropoietin and 5HT2a receptor signalling. ee3_2, a similar gene, is also described, along with human orthologs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AF53-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26638-1", "uniprot_id": [ { "id": "SYSC_MOUSE", "url": "https://www.uniprot.org/uniprot/P26638", "type": "external" } ], "mass": 58389.0, "length": 512, "protein_name": "Serine--tRNA ligase, cytoplasmic", "gene_name": "Sars1", "organism": "Mouse", "refseq_name": "serine--tRNA ligase, cytoplasmic isoform 2", "refseq_ac": [ { "id": "NP_001191908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191908", "type": "external" } ], "gene_names_uniprotkb": "Sars1; Sars; Sers", "gene_names_refseq": "Sars1; Sars; Strs; serRS", "protein_names_uniprotkb": "Serine--tRNA ligase, cytoplasmic; 6.1.1.11; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase", "protein_names_refseq": "serine--tRNA ligase, cytoplasmic isoform 2; serine--tRNA ligase, cytoplasmic; seryl-aminoacyl-tRNA synthetase 1; seryl-tRNA synthetase, cytoplasmic; seryl-tRNA(Ser/Sec) synthetase", "tax_id": 10090, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate carcinoma (Disease Ontology:DOID:10286); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (mmu:20226)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;1918033;21183079;21750661;25605945;29125738;31219806;34400610;34428180;36210013;37453647", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA., [UniProtKB, UniProtKB]; Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2AFR8", "ec_number_list": [ { "id": "6.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006400 tRNA modification;GO:0016525 negative regulation of angiogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26638-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AKQ8-1", "uniprot_id": [ { "id": "I70A2_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AKQ8", "type": "external" } ], "mass": 76120.0, "length": 664, "protein_name": "Intraflagellar transport protein 70A2", "gene_name": "Ift70a2", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 70A2", "refseq_ac": [ { "id": "NP_001074697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074697", "type": "external" } ], "gene_names_uniprotkb": "Ift70a2; Ttc30a2", "gene_names_refseq": "Ift70a2; Ttc30a2", "protein_names_uniprotkb": "Intraflagellar transport protein 70A2; TPR repeat protein 30A2; Tetratricopeptide repeat protein 30A2", "protein_names_refseq": "TPR repeat protein 30A2; intraflagellar transport protein 70A2; novel tetratrico peptide repeat (TPR) containing protein; tetratricopeptide repeat domain 30A2; tetratricopeptide repeat protein 30A2", "tax_id": 10090, "disease": "", "pathway": " (mmu:620631); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;23810713;30084848", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9835, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RXQ0", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A2AKQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70279-1", "uniprot_id": [ { "id": "SURF6_MOUSE", "url": "https://www.uniprot.org/uniprot/P70279", "type": "external" } ], "mass": 41235.0, "length": 355, "protein_name": "Surfeit locus protein 6", "gene_name": "Surf6", "organism": "Mouse", "refseq_name": "surfeit locus protein 6", "refseq_ac": [ { "id": "NP_033324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033324", "type": "external" } ], "gene_names_uniprotkb": "Surf6; Surf-6", "gene_names_refseq": "D2Wsu129e; Surf-6; Surf6", "protein_names_uniprotkb": "Surfeit locus protein 6", "protein_names_refseq": "surfeit locus protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:20935)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16855206;17086444;19907743;21750661;24463520;28873013;29187734;34428180;40021952;8639267;9548374", "class_list": "", "function": "Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly., [UniProtKB, PubMed]; Expression of SURF-6 is essential for mammalian cell viability and cell cycle progression., [RefSeq, PubMed]; SURF6 is a novel positive regulator of proliferation and G1/S transition in mammals., [RefSeq, PubMed]; Surf6 is essential for mouse preimplantation development, presumably by regulating ribosome biogenesis., [RefSeq, PubMed]; The observations suggest that nucleolar protein SURF-6 can act as a marker of early T lymphocyte activation for proliferation and that it could participate in cell cycle regulation in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPI4;Q8BRL7;Q8R0Q7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0001652 granular component", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042254 ribosome biogenesis;GO:0042255 ribosome assembly;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P70279-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H639-1", "uniprot_id": [ { "id": "DRC5_MOUSE", "url": "https://www.uniprot.org/uniprot/A6H639", "type": "external" } ], "mass": 55518.0, "length": 498, "protein_name": "Dynein regulatory complex subunit 5", "gene_name": "Drc5", "organism": "Mouse", "refseq_name": "dynein regulatory complex subunit 5", "refseq_ac": [ { "id": "NP_038716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038716", "type": "external" } ], "gene_names_uniprotkb": "Drc5; D17sil1; Tcte1", "gene_names_refseq": "D17Sil1; Drc5; Tcte-1; Tcte1", "protein_names_uniprotkb": "Dynein regulatory complex subunit 5; T-complex-associated testis-expressed protein 1; Tcte-1", "protein_names_refseq": "T-complex-associated testis-expressed protein 1; dynein regulatory complex subunit 5", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:21645)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2568335;28630322;30084848;31961863", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC (By similarity). Required for sperm motility (PubMed:28630322)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62294", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A6H639-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFI5-1", "uniprot_id": [ { "id": "SYPM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CFI5", "type": "external" } ], "mass": 53518.0, "length": 475, "protein_name": "Probable proline--tRNA ligase, mitochondrial", "gene_name": "Pars2", "organism": "Mouse", "refseq_name": "probable proline--tRNA ligase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001272713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272713", "type": "external" } ], "gene_names_uniprotkb": "Pars2", "gene_names_refseq": "Pars2", "protein_names_uniprotkb": "Probable proline--tRNA ligase, mitochondrial; 6.1.1.15; ProRS; Prolyl-tRNA synthetase", "protein_names_refseq": "class II tRNA synthetase; proRS; probable proline--tRNA ligase, mitochondrial isoform 1; probable proline--tRNA ligase, mitochondrial; probable prolyl-tRNA synthetase, mitochondrial; proline--tRNA ligase", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 75 (Disease Ontology:DOID:0112211)", "pathway": " (mmu:230577)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26495903;34428180", "class_list": "", "function": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AVQ8;Q8R0C4", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" } ], "go_molecular_function": "GO:0004827 proline-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006433 prolyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9EJI9-1", "uniprot_id": [ { "id": "T229A_MOUSE", "url": "https://www.uniprot.org/uniprot/B9EJI9", "type": "external" } ], "mass": 41526.0, "length": 371, "protein_name": "Transmembrane protein 229A", "gene_name": "Tmem229a", "organism": "Mouse", "refseq_name": "transmembrane protein 229A", "refseq_ac": [ { "id": "NP_795987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795987", "type": "external" } ], "gene_names_uniprotkb": "Tmem229a", "gene_names_refseq": "6332401O19Rik; Tmem229a", "protein_names_uniprotkb": "Transmembrane protein 229A", "protein_names_refseq": "transmembrane protein 229A", "tax_id": 10090, "disease": "", "pathway": " (mmu:319832)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B9EJI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X71-1", "uniprot_id": [ { "id": "T106B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X71", "type": "external" } ], "mass": 31172.0, "length": 275, "protein_name": "Transmembrane protein 106B", "gene_name": "Tmem106b", "organism": "Mouse", "refseq_name": "transmembrane protein 106B", "refseq_ac": [ { "id": "NP_082268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082268", "type": "external" } ], "gene_names_uniprotkb": "Tmem106b", "gene_names_refseq": "2310036D22Rik; 5830455K21Rik; 6430519M21Rik; Tmem106b", "protein_names_uniprotkb": "Transmembrane protein 106B", "protein_names_refseq": "transmembrane protein 106B", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 16 (Disease Ontology:DOID:0070405)", "pathway": " (mmu:71900)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10.1101/2023.09.13.557529;16075062;16393994;19144319;21750661;23136129;24872421;25066864;26192747;27802388;28011936;28728022;29855382;30899004;32069316;32160553;32761777;32852886;32929860;34428180;35984892;37828378;38674351;39237682;40885482", "class_list": "", "function": "Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions. Publication Status: Online-Only, [RefSeq, PubMed]; In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864, PubMed:32160553). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (PubMed:32160553). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (Probable). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (PubMed:28728022)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9D737", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007040 lysosome organization;GO:0048813 dendrite morphogenesis;GO:0051345 positive regulation of hydrolase activity;GO:0007041 lysosomal transport;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "Q80X71-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X82-1", "uniprot_id": [ { "id": "SYMPK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X82", "type": "external" } ], "mass": 142620.0, "length": 1288, "protein_name": "Symplekin", "gene_name": "Sympk", "organism": "Mouse", "refseq_name": "symplekin isoform 1", "refseq_ac": [ { "id": "NP_080881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080881", "type": "external" } ], "gene_names_uniprotkb": "Sympk", "gene_names_refseq": "1500016F02Rik; 4632415H16Rik; SPK; SYM; Sympk", "protein_names_uniprotkb": "Symplekin", "protein_names_refseq": "symplekin isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68188); (R-MMU-159231); (R-MMU-72187); (R-MMU-73856); (R-MMU-77595); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "17242355;21183079;21750661;25428506;30084848;30801858;31219806;34428180;39627609", "class_list": "", "function": "Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity (By similarity)., [UniProtKB]; The results indicate that Sympk interacts with Oct4 to promote self-renewal and pluripotency in embryonic stem cells, and it preserves genome integrity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F8WJD4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007155 cell adhesion;GO:0032091 negative regulation of protein binding;GO:0031124 mRNA 3'-end processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80X82-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78S06-1", "uniprot_id": [ { "id": "SYS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78S06", "type": "external" } ], "mass": 17554.0, "length": 156, "protein_name": "Protein SYS1 homolog", "gene_name": "Sys1", "organism": "Mouse", "refseq_name": "protein SYS1 homolog", "refseq_ac": [ { "id": "NP_079851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079851", "type": "external" } ], "gene_names_uniprotkb": "Sys1", "gene_names_refseq": "2610042O14Rik; Sys1", "protein_names_uniprotkb": "Protein SYS1 homolog", "protein_names_refseq": "Sys1 homolog; protein SYS1 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66460); (R-MMU-6811440)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;22872234;30779550;34428180", "class_list": "", "function": "Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UFU1;Q9DAU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0006895 Golgi to endosome transport;GO:0034067 protein localization to Golgi apparatus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q78S06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XT6-1", "uniprot_id": [ { "id": "TAC2N_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XT6", "type": "external" } ], "mass": 54988.0, "length": 489, "protein_name": "Tandem C2 domains nuclear protein", "gene_name": "Tc2n", "organism": "Mouse", "refseq_name": "tandem C2 domains nuclear protein", "refseq_ac": [ { "id": "NP_001076445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076445", "type": "external" } ], "gene_names_uniprotkb": "Tc2n; Mtac2d1", "gene_names_refseq": "4933406D09Rik; Mtac2d1; Tac2-N; Tc2n", "protein_names_uniprotkb": "Tandem C2 domains nuclear protein; Membrane targeting tandem C2 domain-containing protein 1; Tac2-N; Tandem C2 protein in nucleus", "protein_names_refseq": "membrane targeting (tandem) C2 domain containing 1; membrane targeting tandem C2 domain-containing protein 1; tandem C2 domains nuclear protein; tandem C2 protein in nucleus", "tax_id": 10090, "disease": "", "pathway": " (mmu:74413)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11526914;21750661;25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UW74;Q9D4A0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91XT6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE65-1", "uniprot_id": [ { "id": "TAF12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE65", "type": "external" } ], "mass": 17875.0, "length": 161, "protein_name": "Transcription initiation factor TFIID subunit 12", "gene_name": "Taf12", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 12", "refseq_ac": [ { "id": "NP_079855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079855", "type": "external" } ], "gene_names_uniprotkb": "Taf12", "gene_names_refseq": "20kDa; 2810422D08Rik; Taf12; Taf2J", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 12; TAFII-20; TAFII20; Transcription initiation factor TFIID 20 kDa subunits", "protein_names_refseq": "TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa; TAFII-20; TAFII20; transcription initiation factor TFIID 20 kDa subunits; transcription initiation factor TFIID subunit 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:66464); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "17242355;19131326;20173027;21183079;21750661;25428506;30084848;30779550;34301767;35820727", "class_list": "", "function": "The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping., [RefSeq, PubMed]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0S7;Q9CZ11;Q9D8Q0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005669 transcription factor TFIID complex;GO:0000124 SAGA complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VE65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BU30-1", "uniprot_id": [ { "id": "SYIC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BU30", "type": "external" } ], "mass": 144271.0, "length": 1262, "protein_name": "Isoleucine--tRNA ligase, cytoplasmic", "gene_name": "Iars1", "organism": "Mouse", "refseq_name": "isoleucine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_742012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742012", "type": "external" } ], "gene_names_uniprotkb": "Iars1; Iars", "gene_names_refseq": "2510016L12Rik; E430001P04Rik; ILRS; Iars1; Iars", "protein_names_uniprotkb": "Isoleucine--tRNA ligase, cytoplasmic; 6.1.1.5; IRS; IleRS; Isoleucyl-tRNA synthetase", "protein_names_refseq": "IRS; ileRS; isoleucine--tRNA ligase, cytoplasmic; isoleucine-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "", "pathway": " (mmu:105148); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12060739;21750661;22872234;30779550;34428180;34887587;37828378;39627609", "class_list": "", "function": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NXK4", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004822 isoleucine-tRNA ligase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006428 isoleucyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BU30-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08524-1", "uniprot_id": [ { "id": "TECTB_MOUSE", "url": "https://www.uniprot.org/uniprot/O08524", "type": "external" } ], "mass": 36986.0, "length": 329, "protein_name": "Beta-tectorin", "gene_name": "Tectb", "organism": "Mouse", "refseq_name": "beta-tectorin precursor", "refseq_ac": [ { "id": "NP_033374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033374", "type": "external" } ], "gene_names_uniprotkb": "Tectb", "gene_names_refseq": "Tctnb; Tectb", "protein_names_uniprotkb": "Beta-tectorin", "protein_names_refseq": "[b]-tectorin; beta-tectorin precursor; beta-tectorin", "tax_id": 10090, "disease": "", "pathway": " (mmu:21684); (R-MMU-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;25080593;9079715", "class_list": "", "function": "One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB]; One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08524-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C092-1", "uniprot_id": [ { "id": "TAF5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C092", "type": "external" } ], "mass": 87045.0, "length": 801, "protein_name": "Transcription initiation factor TFIID subunit 5", "gene_name": "Taf5", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 5", "refseq_ac": [ { "id": "NP_796316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796316", "type": "external" } ], "gene_names_uniprotkb": "Taf5", "gene_names_refseq": "6330528C20Rik; Taf5", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 5; TAF(II)100; TAFII-100; TAFII100; Transcription initiation factor TFIID 100 kDa subunit", "protein_names_refseq": "TAF(II)100; TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFII-100; TAFII100; Tbp-associated factor 5; transcription initiation factor TFIID 100 kDa subunit; transcription initiation factor TFIID subunit 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:226182); (R-MMU-674695); (R-MMU-6804756); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "21750661;22872234;31219806;34428180;36852467", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8. Involved in contacts between TFIID and TFIIF in the PIC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTR2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:1990841 promoter-specific chromatin binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0000785 chromatin", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C092-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Q9-1", "uniprot_id": [ { "id": "SYVC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1Q9", "type": "external" } ], "mass": 140215.0, "length": 1263, "protein_name": "Valine--tRNA ligase", "gene_name": "Vars1", "organism": "Mouse", "refseq_name": "valine--tRNA ligase", "refseq_ac": [ { "id": "NP_035820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035820", "type": "external" } ], "gene_names_uniprotkb": "Vars1; Bat6; G7a; Vars2; Vars", "gene_names_refseq": "Bat6; D17H6S56E; G7a; Vars1; Vars2; Vars", "protein_names_uniprotkb": "Valine--tRNA ligase; 6.1.1.9; Protein G7a; ValRS; Valyl-tRNA synthetase", "protein_names_refseq": "protein G7a; valRS; valine--tRNA ligase", "tax_id": 10090, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (mmu:22321)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.1101/2023.09.13.557529;10199925;14656967;21750661;22645316;24788674;25428506;29125738;30084848;31599954;34428180;34887587;37453647;37828378;39627609", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUN2", "ec_number_list": [ { "id": "6.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0097228 sperm principal piece", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9Z1Q9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BFQ2-1", "uniprot_id": [ { "id": "T229B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BFQ2", "type": "external" } ], "mass": 19561.0, "length": 167, "protein_name": "Transmembrane protein 229B", "gene_name": "TMEM229B; Tmem229b", "organism": "Mouse", "refseq_name": "transmembrane protein 229B", "refseq_ac": [ { "id": "NP_001163872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163872", "type": "external" } ], "gene_names_uniprotkb": "TMEM229B; Tmem229b", "gene_names_refseq": "6330442E10Rik; 9830138K24; Tmem229b", "protein_names_uniprotkb": "Transmembrane protein 229B", "protein_names_refseq": "transmembrane protein 229B", "tax_id": 10090, "disease": "", "pathway": " (mmu:268567)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31544253;35820727", "class_list": "", "function": "Our data have uncovered the critical contribution of miR-505 in AMD, which is predominantly mediated by downregulation of TMEM229B., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UDU2;Q6AXE5;Q8CCD3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BFQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KK9-1", "uniprot_id": [ { "id": "SYHM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KK9", "type": "external" } ], "mass": 56985.0, "length": 505, "protein_name": "Histidine--tRNA ligase, mitochondrial", "gene_name": "Hars2", "organism": "Mouse", "refseq_name": "histidine--tRNA ligase, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_542367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542367", "type": "external" } ], "gene_names_uniprotkb": "Hars2; Harsl", "gene_names_refseq": "4631412B19Rik; HARSR; HO3; Hars2; Harsl", "protein_names_uniprotkb": "Histidine--tRNA ligase, mitochondrial; 6.1.1.21; HisRS; Histidine--tRNA ligase-like; Histidyl-tRNA synthetase", "protein_names_refseq": "hisRS; histidine--tRNA ligase, mitochondrial isoform 1 precursor; histidyl-tRNA synthetase 2, mitochondrial (putative); probable histidine--tRNA ligase, mitochondrial; probable histidyl-tRNA synthetase, mitochondrial", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Perrault syndrome 2 (Disease Ontology:DOID:0061117); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (mmu:70791)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;31219806;34428180;37507081", "class_list": "", "function": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP)., [UniProtKB, UniProtKB]; This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99KK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0Y1-1", "uniprot_id": [ { "id": "TGIF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0Y1", "type": "external" } ], "mass": 25933.0, "length": 237, "protein_name": "Homeobox protein TGIF2", "gene_name": "Tgif2", "organism": "Mouse", "refseq_name": "homeobox protein TGIF2 isoform b", "refseq_ac": [ { "id": "NP_001278053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278053", "type": "external" } ], "gene_names_uniprotkb": "Tgif2", "gene_names_refseq": "4921501K24; 5730599O09Rik; Tgif2", "protein_names_uniprotkb": "Homeobox protein TGIF2; 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2", "protein_names_refseq": "5'-TG-3'-interacting factor 2; TALE family homeobox; TGF-beta-induced transcription factor 2; TGFB-induced factor 2; homeobox protein TGIF2 isoform b; homeobox protein TGIF2", "tax_id": 10090, "disease": "", "pathway": " (mmu:228839); (R-MMU-2173795)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15749073;16436215;21750661;30872457;31066043;31871777;34741437;35592894", "class_list": "", "function": "Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer., [RefSeq, PubMed]; Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice., [RefSeq, PubMed]; Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence. Publication Status: Online-Only, [RefSeq, PubMed]; TGIF2 has a wide but well controlled expression pattern during mouse development., [RefSeq, PubMed]; Tgif2 plays an important role in the regulation of osteoblastic differentiation in vitro, [RefSeq, PubMed]; The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C0Y1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01853-1", "uniprot_id": [ { "id": "TCC1_MOUSE", "url": "https://www.uniprot.org/uniprot/P01853", "type": "external" } ], "mass": 19101.0, "length": 167, "protein_name": "T-cell receptor gamma chain C region C10.5", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor gamma chain C region C10.5", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "3785427;3917858;6330561", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P01853-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06334-1", "uniprot_id": [ { "id": "TCC3_MOUSE", "url": "https://www.uniprot.org/uniprot/P06334", "type": "external" } ], "mass": 19426.0, "length": 169, "protein_name": "T-cell receptor gamma chain C region DFL12", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell receptor gamma chain C region DFL12", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15821084;3871915", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P06334-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CAX8-1", "uniprot_id": [ { "id": "TGAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P0CAX8", "type": "external" } ], "mass": 55747.0, "length": 505, "protein_name": "T-cell activation GTPase-activating protein 1", "gene_name": "Tagap1", "organism": "Mouse", "refseq_name": "T-cell activation GTPase-activating protein 1", "refseq_ac": [ { "id": "NP_671511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671511", "type": "external" } ], "gene_names_uniprotkb": "Tagap1; Fksg15", "gene_names_refseq": "2610315E15Rik; FKSG15; Tagap1", "protein_names_uniprotkb": "T-cell activation GTPase-activating protein 1", "protein_names_refseq": "T-cell activation GTPase-activating protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:380608)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30059200;31219806", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8K2L9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0CAX8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70324-1", "uniprot_id": [ { "id": "TBX3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70324", "type": "external" } ], "mass": 79160.0, "length": 741, "protein_name": "T-box transcription factor TBX3", "gene_name": "Tbx3", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX3 isoform 1", "refseq_ac": [ { "id": "NP_035665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035665", "type": "external" } ], "gene_names_uniprotkb": "Tbx3", "gene_names_refseq": "D5Ertd189e; Tbx3", "protein_names_uniprotkb": "T-box transcription factor TBX3; T-box protein 3", "protein_names_refseq": "T-box protein 3; T-box transcription factor TBX3 isoform 1; T-box transcription factor TBX3", "tax_id": 10090, "disease": "ulnar-mammary syndrome (Disease Ontology:DOID:0060614); stomach cancer (Disease Ontology:DOID:10534); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:21386); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16222716;17242355;21183079;27720610;30084848;31219806;33795231;34428180;36852467;40997131;7920656;8853987;8878690", "class_list": "", "function": "Transcriptional repressor involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (By similarity). Probably plays a role in limb pattern formation (By similarity). Required for mammary placode induction, and maintenance of the mammary buds during development (PubMed:16222716). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (PubMed:16222716, PubMed:27720610). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (PubMed:27720610). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (PubMed:33795231). Acts as a negative regulator of PML function in cellular senescence (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QM97;Q60708;Q8BWH7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005929 cilium;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0032275 luteinizing hormone secretion;GO:0046884 follicle-stimulating hormone secretion;GO:0030540 female genitalia development;GO:0036302 atrioventricular canal development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P70324-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70327-1", "uniprot_id": [ { "id": "TBX6_MOUSE", "url": "https://www.uniprot.org/uniprot/P70327", "type": "external" } ], "mass": 47006.0, "length": 436, "protein_name": "T-box transcription factor TBX6", "gene_name": "Tbx6", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX6", "refseq_ac": [ { "id": "NP_035668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035668", "type": "external" } ], "gene_names_uniprotkb": "Tbx6", "gene_names_refseq": "Tbx6; rv", "protein_names_uniprotkb": "T-box transcription factor TBX6; T-box protein 6", "protein_names_refseq": "T-box protein 6; T-box transcription factor TBX6; rib-vertebrae", "tax_id": 10090, "disease": "scoliosis (Disease Ontology:DOID:0060249); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); spondylocostal dysostosis 5 (Disease Ontology:DOID:0112363)", "pathway": " (mmu:21389)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15545628;18575602;21331042;34428180;8878690;8954725;9490412", "class_list": "", "function": "T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RU37;Q5SDA2", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0014043 negative regulation of neuron maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70327-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70347-1", "uniprot_id": [ { "id": "TANK_MOUSE", "url": "https://www.uniprot.org/uniprot/P70347", "type": "external" } ], "mass": 50939.0, "length": 448, "protein_name": "TRAF family member-associated NF-kappa-B activator", "gene_name": "Tank", "organism": "Mouse", "refseq_name": "TRAF family member-associated NF-kappa-B activator isoform 2", "refseq_ac": [ { "id": "NP_001157544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157544", "type": "external" } ], "gene_names_uniprotkb": "Tank; Itraf", "gene_names_refseq": "E430026L09Rik; I-TRAF; Tank", "protein_names_uniprotkb": "TRAF family member-associated NF-kappa-B activator; I-TRAF; TRAF-interacting protein", "protein_names_refseq": "TRAF family member-associated NF-kappa-B activator isoform 2; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:21353); (R-MMU-936964); (R-MMU-9824878)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12133833;21750661;32848054;8608943;8710854", "class_list": "", "function": "Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q61178", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0071356 cellular response to tumor necrosis factor;GO:0071347 cellular response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70347-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06666-1", "uniprot_id": [ { "id": "T2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q06666", "type": "external" } ], "mass": 22806.0, "length": 185, "protein_name": "Octapeptide-repeat protein T2", "gene_name": "Srst", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Srst; T2", "gene_names_refseq": "", "protein_names_uniprotkb": "Octapeptide-repeat protein T2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1458435", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06666-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3THK3-1", "uniprot_id": [ { "id": "T2FA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3THK3", "type": "external" } ], "mass": 57241.0, "length": 508, "protein_name": "General transcription factor IIF subunit 1", "gene_name": "Gtf2f1", "organism": "Mouse", "refseq_name": "general transcription factor IIF subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_598562", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598562", "type": "external" } ], "gene_names_uniprotkb": "Gtf2f1", "gene_names_refseq": "2810405L04Rik; Gtf2f1; RAP74", "protein_names_uniprotkb": "General transcription factor IIF subunit 1; TFIIF-alpha; Transcription initiation factor IIF subunit alpha", "protein_names_refseq": "TFIIF-alpha; general transcription factor IIF polypeptide 1 (74kD subunit); general transcription factor IIF subunit 1 isoform 1; general transcription factor IIF subunit 1; transcription initiation factor IIF subunit alpha", "tax_id": 10090, "disease": "", "pathway": " (mmu:98053); (R-MMU-112382); (R-MMU-113418); (R-MMU-674695); (R-MMU-6796648); (R-MMU-6803529); (R-MMU-6807505); (R-MMU-72086); (R-MMU-72163); (R-MMU-72165); (R-MMU-72203); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-75955); (R-MMU-76042); (R-MMU-77075); (R-MMU-9018519); (R-MMU-9770562)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "17242355;17622165;21183079;23806337;28315936", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R5B7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030054 cell junction;GO:0032991 protein-containing complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032091 negative regulation of protein binding;GO:0009615 response to virus;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3THK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TL26-1", "uniprot_id": [ { "id": "TFB2M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TL26", "type": "external" } ], "mass": 45864.0, "length": 396, "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "Tfb2m", "organism": "Mouse", "refseq_name": "dimethyladenosine transferase 2, mitochondrial isoform 3", "refseq_ac": [ { "id": "NP_001317984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317984", "type": "external" } ], "gene_names_uniprotkb": "Tfb2m", "gene_names_refseq": "Hkp1; Tfb2m; mTFB2M; mtTFB2", "protein_names_uniprotkb": "Dimethyladenosine transferase 2, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; mTFB2M; mtTFB2", "protein_names_refseq": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; dimethyladenosine transferase 2, mitochondrial isoform 3; dimethyladenosine transferase 2, mitochondrial; house-keeping protein 1; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2", "tax_id": 10090, "disease": "", "pathway": " (mmu:15278); (R-MMU-163282)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12532263;15526033;28702322", "class_list": "", "function": "Loss of Tfb2m in pancreatic beta-cells results in progressive mitochondrial dysfunction and impaired insulin secretion in response to metabolic stimuli. Publication Status: Online-Only, [RefSeq, PubMed]; Metazoans have two TFBM genes, suggesting that a duplication of the gene has permitted a more flexible regulation of mtDNA., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:15526033). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:15526033). Stimulates transcription independently of the methyltransferase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61669;Q8BTJ2", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TL26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TPR7-1", "uniprot_id": [ { "id": "T184C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TPR7", "type": "external" } ], "mass": 60043.0, "length": 525, "protein_name": "Transmembrane protein 184C", "gene_name": "Tmem184c", "organism": "Mouse", "refseq_name": "transmembrane protein 184C isoform 1", "refseq_ac": [ { "id": "NP_663574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663574", "type": "external" } ], "gene_names_uniprotkb": "Tmem184c; Tmem34", "gene_names_refseq": "8430433H16Rik; Tmem184c; Tmem34", "protein_names_uniprotkb": "Transmembrane protein 184C; Transmembrane protein 34", "protein_names_refseq": "transmembrane protein 184C isoform 1; transmembrane protein 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:234463)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22872234;25428506;30084848;34428180", "class_list": "", "function": "Possible tumor suppressor which may play a role in cell growth., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCD2;Q99KQ7", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TPR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD05-1", "uniprot_id": [ { "id": "TAA8C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QD05", "type": "external" } ], "mass": 37890.0, "length": 344, "protein_name": "Trace amine-associated receptor 8c", "gene_name": "Taar8c", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 8c", "refseq_ac": [ { "id": "NP_001010840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010840", "type": "external" } ], "gene_names_uniprotkb": "Taar8c", "gene_names_refseq": "Taar8c; taR-8c", "protein_names_uniprotkb": "Trace amine-associated receptor 8c; TaR-8c; Trace amine receptor 8c; mTaar8c", "protein_names_refseq": "mTaar8c; trace amine-associated receptor 8c", "tax_id": 10090, "disease": "", "pathway": " (mmu:494546); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15718104;16878137;23624375;37225986", "class_list": "", "function": "Olfactory receptor specific for trace amines, such ascyclohexylamine (1-MPD) (PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RT38", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD05-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD07-1", "uniprot_id": [ { "id": "TAA8A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QD07", "type": "external" } ], "mass": 37848.0, "length": 344, "protein_name": "Trace amine-associated receptor 8a", "gene_name": "Taar8a", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 8a", "refseq_ac": [ { "id": "NP_001010830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010830", "type": "external" } ], "gene_names_uniprotkb": "Taar8a; Gm230", "gene_names_refseq": "Gm230; Taar8a; taR-8a", "protein_names_uniprotkb": "Trace amine-associated receptor 8a; TaR-8a; Trace amine receptor 8a; mTaar8a", "protein_names_refseq": "mTaar8a; trace amine-associated receptor 8a", "tax_id": 10090, "disease": "", "pathway": " (mmu:215859)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15718104;16878137;22442117;23624375", "class_list": "", "function": "Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis., [RefSeq, PubMed]; Olfactory receptor specific for trace amines (By similarity). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (By similarity). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable)., [UniProtKB, UniProtKB]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QD07-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD14-1", "uniprot_id": [ { "id": "TAAR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5QD14", "type": "external" } ], "mass": 38220.0, "length": 337, "protein_name": "Trace amine-associated receptor 5", "gene_name": "Taar5", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 5", "refseq_ac": [ { "id": "NP_001009574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009574", "type": "external" } ], "gene_names_uniprotkb": "Taar5; Gm227", "gene_names_refseq": "Gm227; Taar5; taR-5", "protein_names_uniprotkb": "Trace amine-associated receptor 5; TaR-5; Trace amine receptor 5; Trimethylamine receptor; mTaar5", "protein_names_refseq": "mTaar5; trace amine-associated receptor 5; trimethylamine receptor", "tax_id": 10090, "disease": "", "pathway": " (mmu:215854); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "15718104;16878137;22545963;22837392;23177478;23624375;27208093;30038239;32194374;33132188;34845253;35820727;36038766;37225986;37847527", "class_list": "", "function": "Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice. Publication Status: Online-Only, [RefSeq, PubMed]; Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior (PubMed:16878137, PubMed:22545963, PubMed:23177478, PubMed:27208093, PubMed:30038239, PubMed:37225986, PubMed:37847527). Also activated by N-methylpiperidine (PubMed:22545963). Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant (PubMed:16878137, PubMed:23177478, PubMed:37225986). Trimethylamine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986). Also required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the serotonin system (PubMed:32194374, PubMed:33132188, PubMed:36038766)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity;GO:1990081 trimethylamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007617 mating behavior;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5QD14-1", "record_type": "protein", "filter_code": "0000000.1100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60756-1", "uniprot_id": [ { "id": "TCF15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60756", "type": "external" } ], "mass": 20721.0, "length": 195, "protein_name": "Transcription factor 15", "gene_name": "Tcf15", "organism": "Mouse", "refseq_name": "transcription factor 15", "refseq_ac": [ { "id": "NP_033354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033354", "type": "external" } ], "gene_names_uniprotkb": "Tcf15; Bhlhec2", "gene_names_refseq": "Meso1; Tcf15; bHLH-EC2", "protein_names_uniprotkb": "Transcription factor 15; Meso1; Paraxis; Protein bHLH-EC2; TCF-15", "protein_names_refseq": "TCF-15; paraxis; protein bHLH-EC2; transcription factor 15", "tax_id": 10090, "disease": "", "pathway": " (mmu:21407)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "15226298;21183079;23395635;24038871;25561514;32669716;7597044;7729571;8041747;8825648;8955271", "class_list": "", "function": "Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency (PubMed:23395635, PubMed:24038871, PubMed:32669716, PubMed:7597044, PubMed:8955271). Essential for the mesenchymal to epithelial transition associated with somite formation (PubMed:24038871, PubMed:7597044, PubMed:8955271). Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles (PubMed:8955271). Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition (PubMed:24038871). Also plays a key role in regulation of stem cell pluripotency (PubMed:23395635, PubMed:32669716). Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation (PubMed:23395635). Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal (PubMed:32669716). Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (PubMed:25561514). Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes (PubMed:15226298, PubMed:23395635)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60788", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0003016 respiratory system process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q60756-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61035-1", "uniprot_id": [ { "id": "HARS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61035", "type": "external" } ], "mass": 57432.0, "length": 509, "protein_name": "Histidine--tRNA ligase, cytoplasmic", "gene_name": "Hars1", "organism": "Mouse", "refseq_name": "histidine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_032240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032240", "type": "external" } ], "gene_names_uniprotkb": "Hars1; Hars", "gene_names_refseq": "Hars1; Hars; MMHRS", "protein_names_uniprotkb": "Histidine--tRNA ligase, cytoplasmic; 6.1.1.21; HisRS; Histidyl-tRNA synthetase", "protein_names_refseq": "hisRS; histidine tRNA ligase; histidine--tRNA ligase, cytoplasmic; histidyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)", "pathway": " (mmu:15115)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;23842751;31219806;37507081;8921907", "class_list": "", "function": "AA 60-90 of HRS were absolutely required for in vitro as well as in vivo signaling via MyD88-dependent TLR pathways to case myositis., [RefSeq, PubMed]; Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKU3", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q61035-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62293-1", "uniprot_id": [ { "id": "TGTP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62293", "type": "external" } ], "mass": 47121.0, "length": 415, "protein_name": "T-cell-specific guanine nucleotide triphosphate-binding protein 1", "gene_name": "Tgtp1", "organism": "Mouse", "refseq_name": "T-cell-specific guanine nucleotide triphosphate-binding protein 1", "refseq_ac": [ { "id": "NP_035709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035709", "type": "external" } ], "gene_names_uniprotkb": "Tgtp1; Ifggb5; Irgb6; Mg21", "gene_names_refseq": "Gtp2; Ifggb6; Irgb6; Mg21; Tgtp1; Tgtp2; Tgtp", "protein_names_uniprotkb": "T-cell-specific guanine nucleotide triphosphate-binding protein 1; 3.6.5.-; Interferon-gamma-inducible GTPase Ifggb5", "protein_names_refseq": "Interferon-gamma-inducible GTPase Ifggb6 protein; T-cell specific GTPase; T-cell-specific guanine nucleotide triphosphate-binding protein 1; T-cell-specific guanine nucleotide triphosphate-binding protein 2; interferon-gamma-inducible GTPase Ifggb5", "tax_id": 10090, "disease": "", "pathway": " (mmu:100039796); (mmu:21822)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "16277747;19265156;19285957;20109161;21147463;22761577;22802726;22892676;24324375;24563254;24832449;30779550;31852733;35820727;7836757;7884320;9725230", "class_list": "", "function": "Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii (PubMed:19265156, PubMed:20109161, PubMed:24563254, PubMed:21147463). During avirulent type II T.gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254, PubMed:24324375, PubMed:22802726, PubMed:21147463). Not recruited to virulent type I T.gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q60711;Q8BN19", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0020005 symbiont-containing vacuole membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006955 immune response;GO:0045087 innate immune response;GO:0009617 response to bacterium;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62293-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IEE6-1", "uniprot_id": [ { "id": "T132E_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6IEE6", "type": "external" } ], "mass": 116235.0, "length": 1074, "protein_name": "Transmembrane protein 132E", "gene_name": "Tmem132e", "organism": "Mouse", "refseq_name": "transmembrane protein 132E precursor", "refseq_ac": [ { "id": "NP_001291368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291368", "type": "external" } ], "gene_names_uniprotkb": "Tmem132e; Gm644", "gene_names_refseq": "Gm644; Tmem132e", "protein_names_uniprotkb": "Transmembrane protein 132E", "protein_names_refseq": "transmembrane protein 132E precursor", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 99 (Disease Ontology:DOID:0111634)", "pathway": " (mmu:270893)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;14569139;21750661;25331638", "class_list": "", "function": "Required for normal inner ear hair cell function and hearing., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 9545, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A0A0MQ93;B7ZN59;Q5SUX0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0044297 cell body", "go_biological_process": "GO:0035677 posterior lateral line neuromast hair cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IEE6-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXN1-1", "uniprot_id": [ { "id": "SZRD1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NXN1", "type": "external" } ], "mass": 16998.0, "length": 152, "protein_name": "SUZ RNA-binding domain-containing", "gene_name": "Szrd1", "organism": "Mouse", "refseq_name": "SUZ RNA-binding domain-containing isoform 1", "refseq_ac": [ { "id": "NP_001020779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020779", "type": "external" } ], "gene_names_uniprotkb": "Szrd1; D4Ertd22e", "gene_names_refseq": "1110022I03; D4Ertd22e; Szrd1", "protein_names_uniprotkb": "SUZ RNA-binding domain-containing; SUZ domain-containing protein 1", "protein_names_refseq": "SUZ RNA-binding domain-containing isoform 1; SUZ RNA-binding domain-containing; SUZ domain-containing protein 1; UPF0485 protein C1orf144 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:213491)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19131326;21183079;21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TB72;Q8BT36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6NXN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQA6-1", "uniprot_id": [ { "id": "T2R38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQA6", "type": "external" } ], "mass": 36966.0, "length": 331, "protein_name": "Taste receptor type 2 member 38", "gene_name": "Tas2r38", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 38", "refseq_ac": [ { "id": "NP_001001451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001451", "type": "external" } ], "gene_names_uniprotkb": "Tas2r38; T2r31; Tas2r138", "gene_names_refseq": "T2R138; T2R38; Tas2r138; Tas2r38; mt2r31", "protein_names_uniprotkb": "Taste receptor type 2 member 38; T2R138; T2R38; mT2R31", "protein_names_refseq": "taste receptor type 2 member 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:387513); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12679530;12734386;15886333;34083514", "class_list": "", "function": "Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Publication Status: Online-Only, [RefSeq, PubMed]; Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0PK79;Q4VHF0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TQA6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VP8-1", "uniprot_id": [ { "id": "T106C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VP8", "type": "external" } ], "mass": 28952.0, "length": 260, "protein_name": "Transmembrane protein 106C", "gene_name": "Tmem106c", "organism": "Mouse", "refseq_name": "transmembrane protein 106C isoform 1", "refseq_ac": [ { "id": "NP_001239082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239082", "type": "external" } ], "gene_names_uniprotkb": "Tmem106c; D15Ertd405e", "gene_names_refseq": "D15Ertd405e; Tmem106c", "protein_names_uniprotkb": "Transmembrane protein 106C", "protein_names_refseq": "transmembrane protein 106C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:380967)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;16393994;21750661;26740625;30899004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q80VP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810F8-1", "uniprot_id": [ { "id": "TBX10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810F8", "type": "external" } ], "mass": 42407.0, "length": 385, "protein_name": "T-box transcription factor TBX10", "gene_name": "Tbx10", "organism": "Mouse", "refseq_name": "T-box transcription factor TBX10 isoform 1", "refseq_ac": [ { "id": "NP_001001320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001320", "type": "external" } ], "gene_names_uniprotkb": "Tbx10; Tbx13; Tbx7", "gene_names_refseq": "Dc; Tbx10; Tbx13; Tbx7", "protein_names_uniprotkb": "T-box transcription factor TBX10; MmTBX7; T-box protein 10; T-box protein 13", "protein_names_refseq": "T-box 13; T-box protein 10; T-box protein 13; T-box transcription factor TBX10 isoform 1; T-box transcription factor TBX10; dancer; mmTBX7", "tax_id": 10090, "disease": "", "pathway": " (mmu:109575)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12915323;15118109;9503012", "class_list": "", "function": "Probable transcriptional regulator involved in developmental processes., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O54841;Q32MF8;Q6QH75", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810F8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BLY2-1", "uniprot_id": [ { "id": "SYTC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BLY2", "type": "external" } ], "mass": 91318.0, "length": 790, "protein_name": "Threonine--tRNA ligase 2, cytoplasmic", "gene_name": "Tars3", "organism": "Mouse", "refseq_name": "threonine--tRNA ligase 2, cytoplasmic", "refseq_ac": [ { "id": "NP_758514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758514", "type": "external" } ], "gene_names_uniprotkb": "Tars3; Tarsl2", "gene_names_refseq": "A530046H20Rik; Tars3; Tarsl2", "protein_names_uniprotkb": "Threonine--tRNA ligase 2, cytoplasmic; 6.1.1.3; ThrRS; Threonyl-tRNA synthetase protein 3; Threonyl-tRNA synthetase", "protein_names_refseq": "probable threonine--tRNA ligase 2, cytoplasmic; probable threonyl-tRNA synthetase 2, cytoplasmic; thrRS; threonine--tRNA ligase 2, cytoplasmic; threonyl-tRNA synthetase protein 3; threonyl-tRNA synthetase-like 2; threonyl-tRNA synthetase-like protein 2", "tax_id": 10090, "disease": "nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (mmu:272396)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "29579307;31219806;31287872;37059185", "class_list": "", "function": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage., [UniProtKB, PubMed]; Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., [RefSeq, PubMed]; Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex., [RefSeq, PubMed]; Our results provided the first analysis of the aminoacylation and editing activities of ThrRS-L, and improved our understanding of Tarsl2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHT2", "ec_number_list": [ { "id": "6.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004829 threonine-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BLY2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNE1-1", "uniprot_id": [ { "id": "TCAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNE1", "type": "external" } ], "mass": 102735.0, "length": 924, "protein_name": "TRPM8 channel-associated factor 1", "gene_name": "Tcaf1", "organism": "Mouse", "refseq_name": "TRPM8 channel-associated factor 1 isoform 2", "refseq_ac": [ { "id": "NP_084206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084206", "type": "external" } ], "gene_names_uniprotkb": "Tcaf1; Fam115a; Kiaa0738", "gene_names_refseq": "2810407D09Rik; 3321401G04Rik; A230020K05Rik; Fam115a; Tcaf1", "protein_names_uniprotkb": "TRPM8 channel-associated factor 1; TRP channel-associated factor 1", "protein_names_refseq": "TRP channel-associated factor 1; TRPM8 channel-associated factor 1 isoform 2; family with sequence similarity 115, member A; protein FAM115A", "tax_id": 10090, "disease": "", "pathway": " (mmu:77574)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;25559186;30084848;31219806;34203471;34418053;34428180;36210013", "class_list": "", "function": "Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner., [UniProtKB, UniProtKB]; Report novel TRP channel-associated factors that modulate TRPM8 activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6A005;Q80VG2;Q8BPR4;Q8BTD3;Q8C8Q5;Q8CEM1;Q8CET9;Q8K2D7;Q9D223", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030336 negative regulation of cell migration;GO:0090314 positive regulation of protein targeting to membrane;GO:1901529 positive regulation of anion channel activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BNE1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BY98-1", "uniprot_id": [ { "id": "SWAHD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BY98", "type": "external" } ], "mass": 36297.0, "length": 327, "protein_name": "Ankyrin repeat domain-containing protein SOWAHD", "gene_name": "Sowahd", "organism": "Mouse", "refseq_name": "ankyrin repeat domain-containing protein SOWAHD", "refseq_ac": [ { "id": "NP_776140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776140", "type": "external" } ], "gene_names_uniprotkb": "Sowahd; Ankrd58", "gene_names_refseq": "A630014H24Rik; Ankrd58; Sowahd", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein SOWAHD; Ankyrin repeat domain-containing protein 58; Protein sosondowah homolog D", "protein_names_refseq": "ankyrin repeat domain 58; ankyrin repeat domain-containing protein 58; ankyrin repeat domain-containing protein SOWAHD; protein sosondowah homolog D", "tax_id": 10090, "disease": "", "pathway": " (mmu:245381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BY98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C9V1-1", "uniprot_id": [ { "id": "TB10C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C9V1", "type": "external" } ], "mass": 49930.0, "length": 444, "protein_name": "Carabin", "gene_name": "Tbc1d10c", "organism": "Mouse", "refseq_name": "carabin", "refseq_ac": [ { "id": "NP_848765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848765", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d10c", "gene_names_refseq": "1810062O14Rik; Tbc1d10c", "protein_names_uniprotkb": "Carabin; TBC1 domain family member 10C", "protein_names_refseq": "EBP50-PDZ interactor of 64 kD; carabin", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (mmu:108995); (R-MMU-6798695); (R-MMU-8854214)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21750661;23109291;25369805;34686741;36338148;38084599", "class_list": "", "function": "Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses, [RefSeq, PubMed]; Carabin functions as an endogenous inhibitor of calcineurin, Ras and CamKII kinase which resulted in protection against cardiac hypertrophy., [RefSeq, PubMed]; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity)., [UniProtKB]; Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling. Erratum:[Circ Res. 2024 Feb 16;134(4):e2. doi: 10.1161/RES.0000000000000658. PMID: 38359097], [RefSeq, PubMed]; TBC1D10C is a cytoskeletal functional linker that modulates cell spreading and phagocytosis in macrophages. Publication Status: Online-Only, [RefSeq, PubMed]; Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V3L7;Q6KAN0;Q8C2R6;Q8C6F7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031527 filopodium membrane", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0042147 retrograde transport, endosome to Golgi;GO:0050869 negative regulation of B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8C9V1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0H5-1", "uniprot_id": [ { "id": "TAF10_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0H5", "type": "external" } ], "mass": 21841.0, "length": 218, "protein_name": "Transcription initiation factor TFIID subunit 10", "gene_name": "Taf10", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 10 isoform 1", "refseq_ac": [ { "id": "NP_064408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064408", "type": "external" } ], "gene_names_uniprotkb": "Taf10; Taf2h; Tafii30", "gene_names_refseq": "30kDa; TAFII30; Taf10; Taf2h", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 10; TAF(II)30; TAFII-30; TAFII30; Transcription initiation factor TFIID 30 kDa subunit; mTAFII30", "protein_names_refseq": "TAF(II)30; TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30 kDa; TAFII-30; TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30 kDa; mTAFII30; transcription initiation factor TFIID 30 kDa subunit; transcription initiation factor TFIID subunit 10 isoform 1; transcription initiation factor TFIID subunit 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:24075); (R-MMU-5689880); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 7, "publication_id_list": "10469660;11438666;25870109;25959397;28893950;34428180;40997131", "class_list": "", "function": "By ablating TAF10 specifically in erythroid cells in vivo, observed is a differentiation block accompanied by deregulated GATA1 target genes, including Gata1 itself, suggesting functional cross talk between GATA1 and TAF10., [RefSeq, PubMed]; The TAF10-containing canonical TFIID and SAGA complexes are dispensable for early paraxial mesoderm development, arguing against the generic role in transcription proposed for these fully assembled holo-complexes, [RefSeq, PubMed]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (By similarity). May regulate cyclin E expression (PubMed:10469660)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8H2;Q9QYY5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0030331 nuclear estrogen receptor binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K0H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0L9-1", "uniprot_id": [ { "id": "TADA3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0L9", "type": "external" } ], "mass": 48900.0, "length": 432, "protein_name": "Transcriptional adapter 3", "gene_name": "Tada3", "organism": "Mouse", "refseq_name": "transcriptional adapter 3 isoform 1", "refseq_ac": [ { "id": "NP_598693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598693", "type": "external" } ], "gene_names_uniprotkb": "Tada3; Ada3; Tada3l", "gene_names_refseq": "1110004B19Rik; ADA3; Tada3l; Tada3", "protein_names_uniprotkb": "Transcriptional adapter 3; ADA3 homolog; ADA3-like protein; Transcriptional adapter 3-like; mADA3", "protein_names_refseq": "ADA3 homolog; ADA3-like protein; mADA3; transcriptional adapter 3 isoform 1; transcriptional adapter 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:101206); (R-MMU-5689880); (R-MMU-9772755)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12034840;21750661;22736770;23095635;26429915;27402865", "class_list": "", "function": "A critical role of Ada3 in embryogenesis and cell cycle progression as an essential component of HAT complex., [RefSeq, PubMed]; Demonstrate a novel ADA3 interaction with CENP-B-centromere that may account for its previously known function in mitosis, [RefSeq, PubMed]; Findings demonstrate that acetylation of ADA3 by its associated histone acetyltransferases is essential for its key role in histone acetylation and cell cycle progression. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The loss of Ada3 led to enhanced chromosomal aberrations, such as chromosome breaks, fragments, deletions and translocations, which further increased upon DNA damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIH4;Q8K289;Q8R5E3;Q9CTJ0", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000124 SAGA complex;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R0L9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1G1-1", "uniprot_id": [ { "id": "TASP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1G1", "type": "external" } ], "mass": 44360.0, "length": 420, "protein_name": "Threonine aspartase 1", "gene_name": "Tasp1", "organism": "Mouse", "refseq_name": "threonine aspartase 1 isoform a", "refseq_ac": [ { "id": "NP_001153112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153112", "type": "external" } ], "gene_names_uniprotkb": "Tasp1", "gene_names_refseq": "4930485D02Rik; Tasp1", "protein_names_uniprotkb": "Threonine aspartase 1; 3.4.25.-; Taspase-1", "protein_names_refseq": "taspase-1; threonine aspartase 1 isoform a; threonine aspartase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75812); (R-MMU-9772755)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16951254;18395097;21952136;25428506;25664857;30084848;30573454;30779550", "class_list": "", "function": "Protease responsible for KMT2A/MLL1 and KMT2D/MLL2 processing and activation (PubMed:16951254). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (PubMed:16951254)., [UniProtKB, UniProtKB, PubMed]; TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha, [RefSeq, PubMed]; TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis., [RefSeq, PubMed]; This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression., [RefSeq, PubMed]; Upon loss of taspase1, MLL1 association with chromatin is markedly increased due to the stabilization of its unprocessed version, and this stabilization of the uncleaved MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JP3", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.25.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0045893 positive regulation of DNA-templated transcription;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R1G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCI7-1", "uniprot_id": [ { "id": "SWAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCI7", "type": "external" } ], "mass": 29385.0, "length": 278, "protein_name": "ATPase SWSAP1", "gene_name": "Swsap1", "organism": "Mouse", "refseq_name": "ATPase SWSAP1", "refseq_ac": [ { "id": "NP_080146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080146", "type": "external" } ], "gene_names_uniprotkb": "Swsap1", "gene_names_refseq": "2310047B19Rik; Swsap1", "protein_names_uniprotkb": "ATPase SWSAP1; 3.6.4.-", "protein_names_refseq": "ATPase SWSAP1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66962)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30305635;34253720", "class_list": "", "function": "Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Publication Status: Online-Only, [RefSeq, PubMed]; Single-stranded DNA-stimulated ATPase involved in DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:30305635, PubMed:34253720). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:30305635, PubMed:34253720). The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments (PubMed:30305635, PubMed:34253720). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (By similarity). Has a DNA-binding activity which is independent of its ATPase activity: preferentially binds DNA with an exposed 5' end (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; These results demonstrate an essential role for SWS1-SWSAP1 in meiotic progression and emphasize the complex interplay of factors that ensure recombinase function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7E2S1;Q8BRM3;Q9CV33", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0097196 Shu complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VCI7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WN2-1", "uniprot_id": [ { "id": "T150A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WN2", "type": "external" } ], "mass": 29066.0, "length": 271, "protein_name": "Transmembrane protein 150A", "gene_name": "Tmem150a", "organism": "Mouse", "refseq_name": "transmembrane protein 150A precursor", "refseq_ac": [ { "id": "NP_659165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659165", "type": "external" } ], "gene_names_uniprotkb": "Tmem150a; Tmem150", "gene_names_refseq": "Tmem150a; Tmem150", "protein_names_uniprotkb": "Transmembrane protein 150A; Transmembrane protein 150", "protein_names_refseq": "fasting-inducible integral membrane protein TM6P1; transmembrane protein 150A precursor; transmembrane protein 150", "tax_id": 10090, "disease": "", "pathway": " (mmu:232086)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91WN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZZ3-1", "uniprot_id": [ { "id": "SYUB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91ZZ3", "type": "external" } ], "mass": 14052.0, "length": 133, "protein_name": "Beta-synuclein", "gene_name": "Sncb", "organism": "Mouse", "refseq_name": "beta-synuclein", "refseq_ac": [ { "id": "NP_291088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291088", "type": "external" } ], "gene_names_uniprotkb": "Sncb", "gene_names_refseq": "Sncb; betaSYN", "protein_names_uniprotkb": "Beta-synuclein", "protein_names_refseq": "beta-synuclein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Lewy body dementia (Disease Ontology:DOID:12217); uveitis (Disease Ontology:DOID:13141); Parkinson's disease (Disease Ontology:DOID:14330); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)", "pathway": " (mmu:104069)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10.3389/fragi.2021.757801;11474193;12212795;19189872;20798282;21158410;21183079;22517741;22645316;28657654;32848054;35822049;38703218;40021952;40885482", "class_list": "", "function": "Beta-synuclein decreased formation of Lewy bodies by 40%, and prevented functional deficits associated with overexpression of alpha-synuclein. This is a preliminary in vivo proof of antiaggregatory function of beta-synuclein., [RefSeq, PubMed]; Cell-specific localization of beta-synuclein in the mouse retina., [RefSeq, PubMed]; May be involved in neuronal plasticity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:1903136 cuprous ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0050808 synapse organization;GO:0051402 neuron apoptotic process;GO:0007268 chemical synaptic transmission;GO:0043524 negative regulation of neuron apoptotic process;GO:0042417 dopamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q91ZZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921P9-1", "uniprot_id": [ { "id": "TCAL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921P9", "type": "external" } ], "mass": 19312.0, "length": 165, "protein_name": "Transcription elongation factor A protein-like 1", "gene_name": "Tceal1", "organism": "Mouse", "refseq_name": "transcription elongation factor A protein-like 1", "refseq_ac": [ { "id": "NP_666348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666348", "type": "external" } ], "gene_names_uniprotkb": "Tceal1", "gene_names_refseq": "0610011M09Rik; P21; SIIR; Tceal1; pp21", "protein_names_uniprotkb": "Transcription elongation factor A protein-like 1; TCEA-like protein 1; Transcription elongation factor S-II protein-like 1", "protein_names_refseq": "TCEA-like protein 1; transcription elongation factor A protein-like 1; transcription elongation factor S-II protein-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:237052)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. Does not bind DNA directly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q921P9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923Y8-1", "uniprot_id": [ { "id": "TAAR1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923Y8", "type": "external" } ], "mass": 37621.0, "length": 332, "protein_name": "Trace amine-associated receptor 1", "gene_name": "Taar1", "organism": "Mouse", "refseq_name": "trace amine-associated receptor 1", "refseq_ac": [ { "id": "NP_444435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444435", "type": "external" } ], "gene_names_uniprotkb": "Taar1; Ta1; Tar1; Trar1", "gene_names_refseq": "Taar1; Tar1; Trar1; taR-1", "protein_names_uniprotkb": "Trace amine-associated receptor 1; TaR-1; Trace amine receptor 1", "protein_names_refseq": "trace amine-associated receptor 1", "tax_id": 10090, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (mmu:111174); (R-MMU-375280); (R-MMU-418555)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11459929;15718104;16878137;17212650;22079347;26640076;37225986;37935376;37963465;38514038;38658737", "class_list": "", "function": "Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits., [RefSeq, PubMed]; Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:15718104, PubMed:17212650, PubMed:37935376, PubMed:37963465). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (PubMed:17212650, PubMed:37935376). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (By similarity). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (PubMed:37935376, PubMed:37963465). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:37935376, PubMed:37963465). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (PubMed:37935376, PubMed:37963465). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed:37935376, PubMed:37963465). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (PubMed:37935376, PubMed:37963465)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines., [RefSeq, PubMed]; TAAR1 in dentate gyrus is involved in chronic stress-induced impairments in hippocampal plasticity and cognitive function., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05A85", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001594 trace-amine receptor activity;GO:0008227 G protein-coupled amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q923Y8-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J38-1", "uniprot_id": [ { "id": "I70A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99J38", "type": "external" } ], "mass": 76238.0, "length": 664, "protein_name": "Intraflagellar transport protein 70A1", "gene_name": "Ift70a1", "organism": "Mouse", "refseq_name": "intraflagellar transport protein 70A1", "refseq_ac": [ { "id": "NP_084464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084464", "type": "external" } ], "gene_names_uniprotkb": "Ift70a1; Ttc30a1", "gene_names_refseq": "4930506L13Rik; Ift70a1; Ttc30a1", "protein_names_uniprotkb": "Intraflagellar transport protein 70A1; TPR repeat protein 30A1; Tetratricopeptide repeat protein 30A1", "protein_names_refseq": "TPR repeat protein 30A1; intraflagellar transport protein 70A1; novel tetratrico peptide repeat (TPR) containing protein; tetratricopeptide repeat domain 30A1; tetratricopeptide repeat domain 30A; tetratricopeptide repeat protein 30A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:78802); (R-MMU-5620924)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17971504;23810713;34428180", "class_list": "", "function": "Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip., [UniProtKB]; Ttc30a1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0X1", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005879 axonemal microtubule;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99J38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JX1-1", "uniprot_id": [ { "id": "TAF11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JX1", "type": "external" } ], "mass": 23333.0, "length": 211, "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "Taf11", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 11", "refseq_ac": [ { "id": "NP_081112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081112", "type": "external" } ], "gene_names_uniprotkb": "Taf11", "gene_names_refseq": "1110038O14Rik; PRO214; TAF2I; TAFII28; Taf11", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 11; TAF(II)28; TAFII-28; TAFII28; TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit", "protein_names_refseq": "TAF(II)28; TAFII-28; TFIID subunit p30-beta; transcription initiation factor TFIID 28 kDa subunit; transcription initiation factor TFIID subunit 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:68776); (R-MMU-674695); (R-MMU-6804756); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZH1;Q9CT98", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II;GO:0043923 host-mediated activation of viral transcription;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99JX1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N48-1", "uniprot_id": [ { "id": "SYTL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N48", "type": "external" } ], "mass": 68568.0, "length": 607, "protein_name": "Synaptotagmin-like protein 3", "gene_name": "Sytl3", "organism": "Mouse", "refseq_name": "synaptotagmin-like protein 3 isoform a", "refseq_ac": [ { "id": "NP_113572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113572", "type": "external" } ], "gene_names_uniprotkb": "Sytl3; Slp3", "gene_names_refseq": "A430092N21; Slp3-a; Slp3-b; Slp3; Sytl3; mFLJ00307", "protein_names_uniprotkb": "Synaptotagmin-like protein 3; Exophilin-6", "protein_names_refseq": "exophilin-6; synaptotagmin-like protein 3 isoform a; synaptotagmin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:83672)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11243866;11327731;11773082;12049610;21750661;36210013", "class_list": "", "function": "May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions., [UniProtKB]; Synaptotagmin-like protein 3-a (Slp3-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp3-a specifically and directly binds the GTP-bound form of Rab27A., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3KQQ0;Q8C506;Q99N47;Q99N49;Q99N54;Q99N79", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0005544 calcium-dependent phospholipid binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070382 exocytic vesicle;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99N48-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N50-1", "uniprot_id": [ { "id": "SYTL2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99N50", "type": "external" } ], "mass": 106806.0, "length": 950, "protein_name": "Synaptotagmin-like protein 2", "gene_name": "Sytl2", "organism": "Mouse", "refseq_name": "synaptotagmin-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001035174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035174", "type": "external" } ], "gene_names_uniprotkb": "Sytl2; Slp2", "gene_names_refseq": "Slp2; Sytl2; mKIAA1597", "protein_names_uniprotkb": "Synaptotagmin-like protein 2; Exophilin-4", "protein_names_refseq": "exophilin-4; synaptotagmin-like protein 2 isoform 2; synaptotagmin-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:83671); (R-MMU-9824585)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11243866;11327731;11773082;15543135;16376427;16716193;17114649;17182843;18266782;21750661;22767581;24284068", "class_list": "", "function": "Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane., [UniProtKB, PubMed, PubMed, PubMed]; Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a, [RefSeq, PubMed]; Our findings indicate that Slp2-a controls renal cell size through regulation of Rap-ezrin signaling independently of Rab27., [RefSeq, PubMed]; Slp2-a is required for targeting of the signaling molecule podocalyxin to the apical membrane in a Rab27A-dependent manner., [RefSeq, PubMed]; Synaptotagmin-like protein 2-a (Slp2-a) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp2-a specifically and directly binds the GTP-bound form of Rab27A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2RS48;B7ZNS4;Q8BT37;Q99J89;Q99J90;Q99N51;Q99N52;Q99N55;Q99N56", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0031267 small GTPase binding;GO:0001786 phosphatidylserine binding;GO:0019902 phosphatase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0042470 melanosome;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane;GO:0006887 exocytosis;GO:0070257 positive regulation of mucus secretion;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q99N50-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQY8-1", "uniprot_id": [ { "id": "T4S20_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQY8", "type": "external" } ], "mass": 24760.0, "length": 226, "protein_name": "Transmembrane 4 L6 family member 20", "gene_name": "Tm4sf20", "organism": "Mouse", "refseq_name": "transmembrane 4 L6 family member 20 isoform 1", "refseq_ac": [ { "id": "NP_079729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079729", "type": "external" } ], "gene_names_uniprotkb": "Tm4sf20", "gene_names_refseq": "1810018L02Rik; Tm4sf20", "protein_names_uniprotkb": "Transmembrane 4 L6 family member 20", "protein_names_refseq": "transmembrane 4 L6 family member 20 isoform 1; transmembrane 4 L6 family member 20", "tax_id": 10090, "disease": "specific language impairment (Disease Ontology:DOID:0060244)", "pathway": " (mmu:66261)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D3Q0;Q9D3R0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CQY8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXA2-1", "uniprot_id": [ { "id": "T3HPD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXA2", "type": "external" } ], "mass": 37804.0, "length": 354, "protein_name": "Trans-L-3-hydroxyproline dehydratase", "gene_name": "L3hypdh", "organism": "Mouse", "refseq_name": "trans-L-3-hydroxyproline dehydratase", "refseq_ac": [ { "id": "NP_080314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080314", "type": "external" } ], "gene_names_uniprotkb": "L3hypdh", "gene_names_refseq": "2810055F11Rik; L3hypdh", "protein_names_uniprotkb": "Trans-L-3-hydroxyproline dehydratase; 4.2.1.77; Trans-3-hydroxy-L-proline dehydratase", "protein_names_refseq": "probable proline racemase; trans-3-hydroxy-l-proline dehydratase; trans-L-3-hydroxyproline dehydratase", "tax_id": 10090, "disease": "", "pathway": " (mmu:67217)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22528483;31219806;38342315", "class_list": "", "function": "Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C)., [UniProtKB, PubMed]; Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJ82;Q99KB5", "ec_number_list": [ { "id": "4.2.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.77", "type": "external" } ], "go_molecular_function": "GO:0050346 trans-L-3-hydroxyproline dehydratase activity;GO:0016836 hydro-lyase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CXA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D0I9-1", "uniprot_id": [ { "id": "SYRC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D0I9", "type": "external" } ], "mass": 75674.0, "length": 660, "protein_name": "Arginine--tRNA ligase, cytoplasmic", "gene_name": "Rars1", "organism": "Mouse", "refseq_name": "arginine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_080212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080212", "type": "external" } ], "gene_names_uniprotkb": "Rars1; Rars", "gene_names_refseq": "2610011N19Rik; 2610037E21Rik; Rars1; Rars", "protein_names_uniprotkb": "Arginine--tRNA ligase, cytoplasmic; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "argRS; arginine--tRNA ligase, cytoplasmic; arginyl-tRNA synthetase, cytoplasmic", "tax_id": 10090, "disease": "hypomyelinating leukodystrophy 9 (Disease Ontology:DOID:0060791)", "pathway": " (mmu:104458); (R-MMU-9856649)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12060739;22645316;25428506;28528544;30084848;31599954;34418053;34428180;37453647;37507081;37828378;39627609", "class_list": "", "function": "Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:12060739). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3THP2;Q3TM73;Q3U8R2;Q3U930;Q5SXA8;Q8VDW1", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004814 arginine-tRNA ligase activity;GO:0034618 arginine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9D0I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3R9-1", "uniprot_id": [ { "id": "TAF7L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3R9", "type": "external" } ], "mass": 52905.0, "length": 471, "protein_name": "Transcription initiation factor TFIID subunit 7-like", "gene_name": "Taf7l", "organism": "Mouse", "refseq_name": "transcription initiation factor TFIID subunit 7-like", "refseq_ac": [ { "id": "NP_083234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083234", "type": "external" } ], "gene_names_uniprotkb": "Taf7l; Taf2q", "gene_names_refseq": "4933438I11Rik; Taf2q; Taf7l", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 7-like; TATA box binding protein-associated factor RNA polymerase II subunit Q; TATA box-binding protein-associated factor 50 kDa; Transcription initiation factor TFIID 50 kDa subunit", "protein_names_refseq": "TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor; TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q; TATA box binding protein-associated factor RNA polymerase II subunit Q; TATA box-binding protein-associated factor 50 kDa; transcription initiation factor TFIID 50 kDa subunit; transcription initiation factor TFIID subunit 7-like", "tax_id": 10090, "disease": "oligospermia (Disease Ontology:DOID:14228)", "pathway": " (mmu:74469); (R-MMU-674695); (R-MMU-6804756); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "11279525;12665565;16118233;17242199;21183079;21750661;35554494", "class_list": "", "function": "Genes expressed in germ cells, like Taf7l (Taf2q), are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis., [RefSeq, PubMed]; Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis., [UniProtKB, PubMed]; TAF7L replaces TAF7 as a TFIID subunit in late pachytene spermatocytes and in haploid cells., [RefSeq, PubMed]; Taf7l (Taf2q) is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen., [RefSeq, PubMed]; The mouse D144G substitution is analogous to a missense mutation (D136G) in the X-linked TAF7L gene identified in oligozoospermic men. Although the D144G substitution in mouse does not affect male fertility, RNA-seq analyses revealed alterations in transcriptome profiles in the Taf7l (D144G) mutant testes., [RefSeq, PubMed]; While spermatogenesis was completed in Taf7l(-/Y) mice, the weight of Taf7l(-/Y) testis decreased. Mutant epididymal sperm exhibited abnormal morphology. Sperm motility was significantly reduced, and Taf7l(-/Y) males were fertile with reduced litter size. GeneRIF: Disruption of Taf7l causes reduced testis weight, decreased sperm production and motility, and abnormal morphology, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AFB9;Q99MW7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D3R9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D4V4-1", "uniprot_id": [ { "id": "TAF1D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D4V4", "type": "external" } ], "mass": 36977.0, "length": 322, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "Taf1d", "organism": "Mouse", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D isoform 3", "refseq_ac": [ { "id": "NP_081537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081537", "type": "external" } ], "gene_names_uniprotkb": "Taf1d; Josd3", "gene_names_refseq": "2810003M17Rik; 4930553M18Rik; 5930426I11Rik; Josd3; TAF(I)41; TAFI41; Taf1d", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit D; TATA box-binding protein-associated factor 1D; TBP-associated factor 1D; Transcription initiation factor SL1/TIF-IB subunit D", "protein_names_refseq": "Josephin domain containing 3; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D; TATA box-binding protein-associated factor 1D; TATA box-binding protein-associated factor RNA polymerase I subunit D isoform 3; TATA box-binding protein-associated factor RNA polymerase I subunit D; TBP-associated factor 1D; transcription initiation factor SL1/TIF-IB subunit D", "tax_id": 10090, "disease": "", "pathway": " (mmu:75316); (R-MMU-5250924); (R-MMU-73762); (R-MMU-73772); (R-MMU-73863)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q149X7;Q8C7I5;Q9CZG0;Q9D5U6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0034451 centriolar satellite", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D4V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQT6-1", "uniprot_id": [ { "id": "SYT13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQT6", "type": "external" } ], "mass": 46870.0, "length": 426, "protein_name": "Synaptotagmin-13", "gene_name": "Syt13", "organism": "Mouse", "refseq_name": "synaptotagmin-13", "refseq_ac": [ { "id": "NP_109650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109650", "type": "external" } ], "gene_names_uniprotkb": "Syt13; Kiaa1427", "gene_names_refseq": "5730409J20Rik; Syt13; mKIAA1427", "protein_names_uniprotkb": "Synaptotagmin-13; Synaptotagmin XIII; SytXIII", "protein_names_refseq": "synaptotagmin-13; sytXIII", "tax_id": 10090, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); lung adenocarcinoma (Disease Ontology:DOID:3910); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:80976)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11171101;22872234;25605945;34203471;34428180", "class_list": "", "function": "May be involved in transport vesicle docking to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ZPR2;Q8BRK6", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030133 transport vesicle;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0051726 regulation of cell cycle;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJB1-1", "uniprot_id": [ { "id": "T191_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJB1", "type": "external" } ], "mass": 33974.0, "length": 302, "protein_name": "Transmembrane protein 191", "gene_name": "Tmem191", "organism": "Mouse", "refseq_name": "transmembrane protein 191", "refseq_ac": [ { "id": "NP_803424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803424", "type": "external" } ], "gene_names_uniprotkb": "Tmem191; MNCb-4137; Tmem191c", "gene_names_refseq": "4933405M22Rik; D16Bwg1494e; MNCb-4137; Tmem191c; Tmem191", "protein_names_uniprotkb": "Transmembrane protein 191; Transmembrane protein 191c", "protein_names_refseq": "transmembrane protein 191C; transmembrane protein 191", "tax_id": 10090, "disease": "", "pathway": " (mmu:224019)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1C2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKX3-1", "uniprot_id": [ { "id": "TFR2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKX3", "type": "external" } ], "mass": 88402.0, "length": 798, "protein_name": "Transferrin receptor protein 2", "gene_name": "Tfr2", "organism": "Mouse", "refseq_name": "transferrin receptor protein 2", "refseq_ac": [ { "id": "NP_001276438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276438", "type": "external" } ], "gene_names_uniprotkb": "Tfr2; Trfr2", "gene_names_refseq": "Tfr2; Trfr2", "protein_names_uniprotkb": "Transferrin receptor protein 2; TfR2", "protein_names_refseq": "transferrin receptor protein 2", "tax_id": 10090, "disease": "hemochromatosis type 3 (Disease Ontology:DOID:0111030); hemochromatosis (Disease Ontology:DOID:2352); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (mmu:50765); (R-MMU-917977)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10681454;11239002;11535534;21750661;30084848;34428180;36746004;37349056;38214117;39273097", "class_list": "", "function": "Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD., [RefSeq, PubMed]; Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation., [UniProtKB]; Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis., [RefSeq, PubMed]; Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q920I6;Q99MQ9;Q9CPT2", "ec_number_list": [], "go_molecular_function": "GO:0004998 transferrin receptor activity;GO:0039706 co-receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0031410 cytoplasmic vesicle;GO:1990712 HFE-transferrin receptor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0006898 receptor-mediated endocytosis;GO:0071281 cellular response to iron ion;GO:0010039 response to iron ion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JKX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00262-1", "uniprot_id": [ { "id": "STX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00262", "type": "external" } ], "mass": 33178.0, "length": 289, "protein_name": "Syntaxin-2", "gene_name": "Stx2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stx2; Epim", "gene_names_refseq": "", "protein_names_uniprotkb": "Syntaxin-2; Epimorphin", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "15774481;1581962;21750661;36696506;7957204", "class_list": "", "function": "Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005198 structural molecule activity;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0030033 microvillus assembly;GO:0006886 intracellular protein transport;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00262-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50427-1", "uniprot_id": [ { "id": "STS_MOUSE", "url": "https://www.uniprot.org/uniprot/P50427", "type": "external" } ], "mass": 66591.0, "length": 624, "protein_name": "Steryl-sulfatase", "gene_name": "Sts", "organism": "Mouse", "refseq_name": "steryl-sulfatase precursor", "refseq_ac": [ { "id": "NP_033319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033319", "type": "external" } ], "gene_names_uniprotkb": "Sts", "gene_names_refseq": "ArsC; Sts", "protein_names_uniprotkb": "Steryl-sulfatase; 3.1.6.2; ASC; Arylsulfatase C; Steroid sulfatase; Steryl-sulfate sulfohydrolase", "protein_names_refseq": "ASC; arylsulfatase C; steryl-sulfatase precursor; steryl-sulfatase; steryl-sulfate sulfohydrolase", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); X-linked ichthyosis (Disease Ontology:DOID:1700)", "pathway": " (mmu:20905); (R-MMU-1663150); (R-MMU-196071); (R-MMU-9840310)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22189290;24497646;30060148;30779550;34428180;40997131;8673109", "class_list": "glycogene", "function": "Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid., [UniProtKB, UniProtKB]; Overexpression of STS in the liver improved metabolic functions in mouse models of obesity and type 2 diabetes through sex-specific mechanisms., [RefSeq, PubMed]; Results revealed an essential role of the adipose STS in energy homeostasis in sex- and sex hormone-dependent manner. Adipose expression of Sts was induced in the high-fat diet (HFD) and ob/ob models of obesity and type 2 diabetes., [RefSeq, PubMed]; These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.2", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "1.8.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.7", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0008484 sulfuric ester hydrolase activity;GO:0004773 steryl-sulfatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007611 learning or memory;GO:0008284 positive regulation of cell population proliferation;GO:0007565 female pregnancy;GO:0009268 response to pH;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P50427-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000011000.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27090-1", "uniprot_id": [ { "id": "TGFB2_MOUSE", "url": "https://www.uniprot.org/uniprot/P27090", "type": "external" } ], "mass": 47589.0, "length": 414, "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "Tgfb2", "organism": "Mouse", "refseq_name": "transforming growth factor beta-2 proprotein isoform 1 preproprotein", "refseq_ac": [ { "id": "NP_033393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033393", "type": "external" } ], "gene_names_uniprotkb": "Tgfb2", "gene_names_refseq": "Tgf-beta2; Tgfb-2; Tgfb2", "protein_names_uniprotkb": "Transforming growth factor beta-2 proprotein", "protein_names_refseq": "transforming growth factor beta-2 proprotein isoform 1 preproprotein; transforming growth factor beta-2 proprotein", "tax_id": 10090, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); Camurati-Engelmann disease 2 (Disease Ontology:DOID:0061230); Loeys-Dietz syndrome 4 (Disease Ontology:DOID:0070233); colon carcinoma (Disease Ontology:DOID:1520); osteochondrodysplasia (Disease Ontology:DOID:2256); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cirrhosis (Disease Ontology:DOID:5082); pancreatic adenosquamous carcinoma (Disease Ontology:DOID:5637); myocardial infarction (Disease Ontology:DOID:5844); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (mmu:21808); (R-MMU-114608); (R-MMU-2129379); (R-MMU-2173789); (R-MMU-9839389)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;14973287;14985127;15206957;21750661;23963447;25428506;2797004;30899004", "class_list": "", "function": "Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 2, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q91VP5", "ec_number_list": [], "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0046580 negative regulation of Ras protein signal transduction;GO:0045617 negative regulation of keratinocyte differentiation;GO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis;GO:1903701 substantia propria of cornea development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P27090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VB26-1", "uniprot_id": [ { "id": "TEX26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0VB26", "type": "external" } ], "mass": 34527.0, "length": 296, "protein_name": "Testis-expressed protein 26", "gene_name": "Tex26", "organism": "Mouse", "refseq_name": "testis-expressed protein 26 isoform 1", "refseq_ac": [ { "id": "NP_083740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083740", "type": "external" } ], "gene_names_uniprotkb": "Tex26", "gene_names_refseq": "4930588N13Rik; Tex26", "protein_names_uniprotkb": "Testis-expressed protein 26", "protein_names_refseq": "testis-expressed protein 26 isoform 1; testis-expressed protein 26; testis-expressed sequence 26 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75860)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VB26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921N7-1", "uniprot_id": [ { "id": "TMM70_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921N7", "type": "external" } ], "mass": 28275.0, "length": 253, "protein_name": "Transmembrane protein 70, mitochondrial", "gene_name": "Tmem70", "organism": "Mouse", "refseq_name": "transmembrane protein 70, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_080668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080668", "type": "external" } ], "gene_names_uniprotkb": "Tmem70", "gene_names_refseq": "1110020A09Rik; 2210416J16Rik; Tmem70", "protein_names_uniprotkb": "Transmembrane protein 70, mitochondrial", "protein_names_refseq": "transmembrane protein 70, mitochondrial isoform 2; transmembrane protein 70, mitochondrial", "tax_id": 10090, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 2 (Disease Ontology:DOID:0060331)", "pathway": " (mmu:70397)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20485683;21750661;28173120;31219806;31652072", "class_list": "", "function": "Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (By similarity). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:28173120, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKB6;Q3UAP8;Q9CQY4;Q9D7R8", "ec_number_list": [], "go_molecular_function": "GO:0140260 mitochondrial proton-transporting ATP synthase complex binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0051260 protein homooligomerization;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921N7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48301-1", "uniprot_id": [ { "id": "TEAD2_MOUSE", "url": "https://www.uniprot.org/uniprot/P48301", "type": "external" } ], "mass": 49041.0, "length": 445, "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "Tead2", "organism": "Mouse", "refseq_name": "transcriptional enhancer factor TEF-4 isoform a", "refseq_ac": [ { "id": "NP_001272427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272427", "type": "external" } ], "gene_names_uniprotkb": "Tead2; Etdf; Etf; Tef4", "gene_names_refseq": "ETEF-1; ETF; Etdf; TEAD-2; TEF-4; TEF4; Tead2", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-4; ETEF-1; ETF; Embryonic TEA domain-containing factor; TEA domain family member 2; TEAD-2", "protein_names_refseq": "embryonic TEA domain-containing factor; transcriptional enhancer factor TEF-4 isoform a; transcriptional enhancer factor TEF-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:21677); (R-MMU-2032785); (R-MMU-8951671)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "21750661;31219806;38605224;7629195;8702974;8812452;9169843", "class_list": "", "function": "TEAD2 initiates ground-state pluripotency by mediating chromatin looping., [RefSeq, PubMed]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62297", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0140552 TEAD-YAP complex;GO:0005634 nucleus", "go_biological_process": "GO:0001570 vasculogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48301-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D305-1", "uniprot_id": [ { "id": "THAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D305", "type": "external" } ], "mass": 24993.0, "length": 217, "protein_name": "THAP domain-containing protein 2", "gene_name": "Thap2", "organism": "Mouse", "refseq_name": "THAP domain-containing protein 2", "refseq_ac": [ { "id": "NP_080056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080056", "type": "external" } ], "gene_names_uniprotkb": "Thap2", "gene_names_refseq": "2900040O07Rik; 9030625G08Rik; Thap2", "protein_names_uniprotkb": "THAP domain-containing protein 2", "protein_names_refseq": "THAP domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66816)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D305-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJ25-1", "uniprot_id": [ { "id": "THAP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJ25", "type": "external" } ], "mass": 24627.0, "length": 218, "protein_name": "THAP domain-containing protein 3", "gene_name": "Thap3", "organism": "Mouse", "refseq_name": "THAP domain-containing protein 3 isoform 1", "refseq_ac": [ { "id": "NP_780361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780361", "type": "external" } ], "gene_names_uniprotkb": "Thap3", "gene_names_refseq": "2010013E08Rik; 2210418H06Rik; Thap3", "protein_names_uniprotkb": "THAP domain-containing protein 3", "protein_names_refseq": "THAP domain-containing protein 3 isoform 1; THAP domain-containing protein 3; snoRNA MBI-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:69876)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20200153;21750661;25428506;30084848", "class_list": "", "function": "Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BII6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8BJ25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0V7-1", "uniprot_id": [ { "id": "TI17B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z0V7", "type": "external" } ], "mass": 18352.0, "length": 172, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim17-B", "gene_name": "Timm17b", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim17-B isoform 1", "refseq_ac": [ { "id": "NP_035721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035721", "type": "external" } ], "gene_names_uniprotkb": "Timm17b; Tim17b", "gene_names_refseq": "17kDa; Sfc3; Timm17b; mTim17b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim17-B", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim17-B isoform 1; mitochondrial import inner membrane translocase subunit Tim17-B; translocator of inner mitochondrial membrane 17 kDa, b; translocator of inner mitochondrial membrane 17b; translocator of inner mitochondrial membrane b", "tax_id": 10090, "disease": "", "pathway": " (mmu:21855)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10339406;21750661", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z0V7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YV9-1", "uniprot_id": [ { "id": "PGAP4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YV9", "type": "external" } ], "mass": 46592.0, "length": 403, "protein_name": "GPI-N-acetylgalactosamine transferase PGAP4", "gene_name": "Pgap4", "organism": "Mouse", "refseq_name": "GPI-N-acetylgalactosamine transferase PGAP4", "refseq_ac": [ { "id": "NP_080220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080220", "type": "external" } ], "gene_names_uniprotkb": "Pgap4; 2810432L12Rik; Tmem246", "gene_names_refseq": "2810432L12Rik; 9330170P15Rik; Pgap4; Tmem246", "protein_names_uniprotkb": "GPI-N-acetylgalactosamine transferase PGAP4; 2.4.1.-; GPI-GalNAc transferase PGAP4; Post-GPI attachment to proteins GalNAc transferase 4; Post-GPI attachment to proteins factor 4; Transmembrane protein 246", "protein_names_refseq": "GPI-GalNAc transferase PGAP4; GPI-N-acetylgalactosamine transferase PGAP4; post-GPI attachment to proteins factor 4; transmembrane protein 246; transmembrane protein C9orf125 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67063)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Golgi-resident glycosylphosphatidylinositol (GPI)-N-acetylgalactosamine transferase that catalyzes the N-acetyl-beta-D-galactosamine transfer from an UDP-N-acetyl-alpha-D-galactosamine to the 4-OH-position of first mannose of the glycosylphosphatidylinositol (GPI) of a GPI-anchored protein (GPI-AP). This modification occurs after the fatty acid remodeling step of the GPI-anchor maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TN50;Q9CYX3", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91YV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E1Z1-1", "uniprot_id": [ { "id": "TM215_MOUSE", "url": "https://www.uniprot.org/uniprot/A7E1Z1", "type": "external" } ], "mass": 25812.0, "length": 235, "protein_name": "Transmembrane protein 215", "gene_name": "Tmem215", "organism": "Mouse", "refseq_name": "transmembrane protein 215", "refseq_ac": [ { "id": "NP_001159481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159481", "type": "external" } ], "gene_names_uniprotkb": "Tmem215", "gene_names_refseq": "A930001M12Rik; Tmem215", "protein_names_uniprotkb": "Transmembrane protein 215", "protein_names_refseq": "transmembrane protein 215", "tax_id": 10090, "disease": "", "pathway": " (mmu:320500)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30370660", "class_list": "", "function": "These results identified TMEM215 as a novel molecule involved in angiogenesis by regulating the survival of endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C8R5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0002040 sprouting angiogenesis;GO:0046671 negative regulation of retinal cell programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E1Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHQ6-1", "uniprot_id": [ { "id": "TM125_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CHQ6", "type": "external" } ], "mass": 22055.0, "length": 216, "protein_name": "Transmembrane protein 125", "gene_name": "Tmem125", "organism": "Mouse", "refseq_name": "transmembrane protein 125", "refseq_ac": [ { "id": "NP_759015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_759015", "type": "external" } ], "gene_names_uniprotkb": "Tmem125", "gene_names_refseq": "6330530A05Rik; Tmem125", "protein_names_uniprotkb": "Transmembrane protein 125", "protein_names_refseq": "transmembrane protein 125", "tax_id": 10090, "disease": "", "pathway": " (mmu:230678)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2BI56;Q8BHY6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSK3-1", "uniprot_id": [ { "id": "TEFM_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSK3", "type": "external" } ], "mass": 41874.0, "length": 364, "protein_name": "Transcription elongation factor, mitochondrial", "gene_name": "Tefm", "organism": "Mouse", "refseq_name": "transcription elongation factor, mitochondrial", "refseq_ac": [ { "id": "NP_899098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899098", "type": "external" } ], "gene_names_uniprotkb": "Tefm; 1110002N22Rik", "gene_names_refseq": "1110002N22Rik; Tefm", "protein_names_uniprotkb": "Transcription elongation factor, mitochondrial", "protein_names_refseq": "transcription elongation factor, mitochondrial", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286)", "pathway": " (mmu:68550)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31036713", "class_list": "", "function": "Our data demonstrate that TEFM acts as a general transcription elongation factor, necessary for both gene transcription and replication primer formation, and loss of TEFM affects RNA processing in mammalian mitochondria., [RefSeq, PubMed]; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006392 transcription elongation by mitochondrial RNA polymerase;GO:0002082 regulation of oxidative phosphorylation;GO:1903109 positive regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5SSK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TUU5-1", "uniprot_id": [ { "id": "TEX30_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TUU5", "type": "external" } ], "mass": 25263.0, "length": 225, "protein_name": "Testis-expressed protein 30", "gene_name": "Tex30", "organism": "Mouse", "refseq_name": "testis-expressed protein 30", "refseq_ac": [ { "id": "NP_083644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083644", "type": "external" } ], "gene_names_uniprotkb": "Tex30; 1700029F09Rik", "gene_names_refseq": "1700029F09Rik; 3110030D08Rik; Tex30", "protein_names_uniprotkb": "Testis-expressed protein 30", "protein_names_refseq": "testis-expressed protein 30; testis-expressed sequence 30 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75623)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;22872234;31219806;34203471;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KKZ6;Q9D9T9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TUU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D9U4-1", "uniprot_id": [ { "id": "TEX22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D9U4", "type": "external" } ], "mass": 21502.0, "length": 189, "protein_name": "Testis-expressed protein 22", "gene_name": "Tex22", "organism": "Mouse", "refseq_name": "testis-expressed protein 22", "refseq_ac": [ { "id": "NP_083657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083657", "type": "external" } ], "gene_names_uniprotkb": "Tex22; Tep22", "gene_names_refseq": "1700028O09Rik; Tep22; Tex22", "protein_names_uniprotkb": "Testis-expressed protein 22; Testis-expressed protein of 22 kDa", "protein_names_refseq": "testis-expressed protein 22; testis-expressed protein of 22 kDa; testis-expressed sequence 22 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:75671)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12359214;21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ZP5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D9U4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ10-1", "uniprot_id": [ { "id": "TM11G_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ10", "type": "external" } ], "mass": 46614.0, "length": 417, "protein_name": "Transmembrane protease serine 11G", "gene_name": "Tmprss11g", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11G", "refseq_ac": [ { "id": "NP_796136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796136", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11g; Desc4", "gene_names_refseq": "9930032O22Rik; Desc4; Tmprss11g", "protein_names_uniprotkb": "Transmembrane protease serine 11G; 3.4.21.-; Serine protease DESC4", "protein_names_refseq": "serine protease Desc4; transmembrane protease serine 11G", "tax_id": 10090, "disease": "", "pathway": " (mmu:320454)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36210013", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ04", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BZ10-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQI0-1", "uniprot_id": [ { "id": "TM204_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TQI0", "type": "external" } ], "mass": 24785.0, "length": 226, "protein_name": "Transmembrane protein 204", "gene_name": "Tmem204", "organism": "Mouse", "refseq_name": "transmembrane protein 204 precursor", "refseq_ac": [ { "id": "NP_001001183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001183", "type": "external" } ], "gene_names_uniprotkb": "Tmem204; Clp24", "gene_names_refseq": "Clp24; Tmem204", "protein_names_uniprotkb": "Transmembrane protein 204; Claudin-like protein 24", "protein_names_refseq": "claudin-like protein 24; transmembrane protein 204 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:407831)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20439428;21750661", "class_list": "", "function": "CLP24 is a novel regulator of VEGFR-2 and VEGFR-3 signaling pathways and of normal lymphatic vessel structure, [RefSeq, PubMed]; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0051145 smooth muscle cell differentiation;GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway;GO:0001945 lymph vessel development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TQI0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MX0-1", "uniprot_id": [ { "id": "TKTL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MX0", "type": "external" } ], "mass": 65245.0, "length": 595, "protein_name": "Transketolase-like protein 1", "gene_name": "Tktl1", "organism": "Mouse", "refseq_name": "transketolase-like protein 1", "refseq_ac": [ { "id": "NP_113556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113556", "type": "external" } ], "gene_names_uniprotkb": "Tktl1", "gene_names_refseq": "Tktl1", "protein_names_uniprotkb": "Transketolase-like protein 1; 2.2.1.1; TK 2; Transketolase 2", "protein_names_refseq": "TK 2; transketolase 2; transketolase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83553)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11279525;16118233;17660561;21233279;21750661;25428506;25605945;34428180;36074851", "class_list": "", "function": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity)., [UniProtKB, UniProtKB]; Germ-cell-specific sex-linked genes, like Tktl1, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis., [RefSeq, PubMed]; TKTL1 plays a role during mucosal repair and restoration., [RefSeq, PubMed]; Tktl1 is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen., [RefSeq, PubMed]; Transcripts highly enriched in ovary; gene identified as candidate female fertility factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AYP0;Q684Q5;Q8CDU7", "ec_number_list": [ { "id": "2.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004802 transketolase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99MX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C3K5-1", "uniprot_id": [ { "id": "TMM72_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C3K5", "type": "external" } ], "mass": 30372.0, "length": 275, "protein_name": "Transmembrane protein 72", "gene_name": "Tmem72", "organism": "Mouse", "refseq_name": "transmembrane protein 72", "refseq_ac": [ { "id": "NP_848883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848883", "type": "external" } ], "gene_names_uniprotkb": "Tmem72", "gene_names_refseq": "C230095G01Rik; Tmem72", "protein_names_uniprotkb": "Transmembrane protein 72", "protein_names_refseq": "transmembrane protein 72", "tax_id": 10090, "disease": "", "pathway": " (mmu:319776)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGN8;Q3URE2;Q8C7L8;Q8C7X5;Q8CC57", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8C3K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CRG1-1", "uniprot_id": [ { "id": "TM7S3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CRG1", "type": "external" } ], "mass": 63251.0, "length": 565, "protein_name": "Transmembrane 7 superfamily member 3", "gene_name": "Tm7sf3", "organism": "Mouse", "refseq_name": "transmembrane 7 superfamily member 3 precursor", "refseq_ac": [ { "id": "NP_080557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080557", "type": "external" } ], "gene_names_uniprotkb": "Tm7sf3", "gene_names_refseq": "2010003B14Rik; NARP1; Tm7sf3", "protein_names_uniprotkb": "Transmembrane 7 superfamily member 3; NARP1", "protein_names_refseq": "transmembrane 7 superfamily member 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:67623)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21750661;21853325;27740623;33691755;34428180", "class_list": "", "function": "Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells., [RefSeq, PubMed]; Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623)., [UniProtKB, PubMed, PubMed, UniProtKB]; The NF-kappaB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3TBQ2;Q3U3Q6;Q4F873;Q6PES5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0043069 negative regulation of programmed cell death;GO:0034620 cellular response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CRG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXE7-1", "uniprot_id": [ { "id": "TMED5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXE7", "type": "external" } ], "mass": 26172.0, "length": 229, "protein_name": "Transmembrane emp24 domain-containing protein 5", "gene_name": "Tmed5", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_083152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083152", "type": "external" } ], "gene_names_uniprotkb": "Tmed5", "gene_names_refseq": "3110020O18Rik; 4432412D15Rik; Tmed5; p24gamma2", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 5; p24 family protein gamma-2; p24gamma2", "protein_names_refseq": "p24 family protein gamma-2; transmembrane emp24 domain-containing protein 5 isoform 1 precursor; transmembrane emp24 domain-containing protein 5; transmembrane emp24 protein transport domain containing 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:73130); (R-MMU-3238698)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21750661;28066915;31219806;34428180", "class_list": "", "function": "Crystallographic analysis of murine p24gamma2 Golgi dynamics domain has been reported., [RefSeq, PubMed]; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDS6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0090161 Golgi ribbon formation;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CXE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30051-1", "uniprot_id": [ { "id": "TEAD1_MOUSE", "url": "https://www.uniprot.org/uniprot/P30051", "type": "external" } ], "mass": 47948.0, "length": 426, "protein_name": "Transcriptional enhancer factor TEF-1", "gene_name": "Tead1", "organism": "Mouse", "refseq_name": "transcriptional enhancer factor TEF-1 isoform 3", "refseq_ac": [ { "id": "NP_001160057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160057", "type": "external" } ], "gene_names_uniprotkb": "Tead1; Tcf13; Tef-1; Tef1", "gene_names_refseq": "2610024B07Rik; B230114H05Rik; Gtrgeo5; TEAD-1; TEF-1; Tcf13; Tead1; mTEF-1", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-1; NTEF-1; Protein GT-IIC; TCF-13; TEA domain family member 1; TEAD-1; Transcription factor 13", "protein_names_refseq": "NTEF-1; TCF-13; transcription factor 13; transcriptional enhancer factor TEF-1 isoform 3; transcriptional enhancer factor TEF-1", "tax_id": 10090, "disease": "Sveinsson chorioretinal atrophy (Disease Ontology:DOID:0111228)", "pathway": " (mmu:21676); (R-MMU-2032785); (R-MMU-8951671)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1851669;21750661;30779550;31219806;34428180;7958896;8396764;8441689", "class_list": "", "function": "Studies in human provide evidence for the exclusive use of a non-AUG (AUU) start codon for translation initiation in vivo. This AUU codon is highly conserved among vertebrates., [RefSeq, PubMed]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0140552 TEAD-YAP complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30051-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U405-1", "uniprot_id": [ { "id": "TMPSD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U405", "type": "external" } ], "mass": 59806.0, "length": 543, "protein_name": "Transmembrane protease serine 13", "gene_name": "Tmprss13", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmprss13; Msp", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 13; 3.4.21.-; Membrane-type mosaic serine protease; Mosaic serine protease", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:214531)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;24832573", "class_list": "", "function": "Serine protease (By similarity). Cleaves the proform of PRSS8/prostasin to form the active protein (By similarity). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (By similarity). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (PubMed:24832573)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFE0;Q91VQ8", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016485 protein processing;GO:0061436 establishment of skin barrier;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U405-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70210-1", "uniprot_id": [ { "id": "TEAD3_MOUSE", "url": "https://www.uniprot.org/uniprot/P70210", "type": "external" } ], "mass": 48938.0, "length": 439, "protein_name": "Transcriptional enhancer factor TEF-5", "gene_name": "Tead3", "organism": "Mouse", "refseq_name": "transcriptional enhancer factor TEF-5 isoform 1", "refseq_ac": [ { "id": "NP_001091696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091696", "type": "external" } ], "gene_names_uniprotkb": "Tead3; Tcf13r2; Tef5", "gene_names_refseq": "DTEF-1; ETFR-1; TEAD-3; TEF-5; Tcf13r2; Tead3", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-5; DTEF-1; ETF-related factor 1; ETFR-1; TEA domain family member 3; TEAD-3", "protein_names_refseq": "ETF-related factor 1; transcriptional enhancer factor TEF-5 isoform 1; transcriptional enhancer factor TEF-5", "tax_id": 10090, "disease": "", "pathway": " (mmu:21678); (R-MMU-2032785); (R-MMU-8951671)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10379887;21750661;36516960;8920920;9502435;9671946", "class_list": "", "function": "Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells. Erratum:[Gene Expr Patterns. 2023 Sep;49:119332. doi: 10.1016/j.gep.2023.119332. PMID: 37523912], [RefSeq, PubMed]; Experimental evidence for non-AUG translation initiation of human TEF-5. This non-AUG start site, AUA, is conserved in mouse., [RefSeq, PubMed]; This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08516;O70623;P70209", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70210-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBT0-1", "uniprot_id": [ { "id": "TMX1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VBT0", "type": "external" } ], "mass": 31396.0, "length": 278, "protein_name": "Thioredoxin-related transmembrane protein 1", "gene_name": "Tmx1", "organism": "Mouse", "refseq_name": "thioredoxin-related transmembrane protein 1 precursor", "refseq_ac": [ { "id": "NP_082615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082615", "type": "external" } ], "gene_names_uniprotkb": "Tmx1; Txndc1; Txndc", "gene_names_refseq": "2810425A04Rik; Tmx1; Txndc1", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 1; 5.3.4.1; Protein disulfide-isomerase TMX1; Thioredoxin domain-containing protein 1", "protein_names_refseq": "protein disulfide-isomerase TMX1; thioredoxin domain containing 1; thioredoxin domain-containing protein 1; thioredoxin-related transmembrane protein 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:72736)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "17114649;17208939;17242355;18630941;19131326;19144319;21183079;21750661;25428506;26246604;28528544;30044099;30425049", "class_list": "", "function": "TMX1 as an oxidative stress protective factor., [RefSeq, PubMed]; Thioredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:26246604). Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol (By similarity). The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds (PubMed:26246604). Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane (PubMed:26246604). Involved in ER-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane (By similarity). Acts as a negative regulator of platelet aggregation following secretion in the extracellular space (PubMed:30425049). Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals (By similarity). Regulates endoplasmic reticulum-mitochondria Ca(2+) flux (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UCI8;Q9CSD5", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0004857 enzyme inhibitor activity;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051924 regulation of calcium ion transport;GO:0019432 triglyceride biosynthetic process;GO:0034976 response to endoplasmic reticulum stress;GO:1904294 positive regulation of ERAD pathway;GO:0010868 negative regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VBT0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVA2-1", "uniprot_id": [ { "id": "TM222_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVA2", "type": "external" } ], "mass": 23180.0, "length": 208, "protein_name": "Transmembrane protein 222", "gene_name": "Tmem222", "organism": "Mouse", "refseq_name": "transmembrane protein 222", "refseq_ac": [ { "id": "NP_079943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079943", "type": "external" } ], "gene_names_uniprotkb": "Tmem222; D4Ertd196e", "gene_names_refseq": "5730406H10Rik; D4Ertd196e; Tmem222", "protein_names_uniprotkb": "Transmembrane protein 222", "protein_names_refseq": "transmembrane protein 222", "tax_id": 10090, "disease": "", "pathway": " (mmu:52174)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AE96;Q8CI41;Q9CYN3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BVA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LB0-1", "uniprot_id": [ { "id": "TDIF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LB0", "type": "external" } ], "mass": 36852.0, "length": 328, "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "gene_name": "Dnttip1", "organism": "Mouse", "refseq_name": "deoxynucleotidyltransferase terminal-interacting protein 1", "refseq_ac": [ { "id": "NP_598524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598524", "type": "external" } ], "gene_names_uniprotkb": "Dnttip1; Tdif1", "gene_names_refseq": "6430706C13Rik; Dnttip1", "protein_names_uniprotkb": "Deoxynucleotidyltransferase terminal-interacting protein 1; TdIF1; TdT-interacting factor 1; Terminal deoxynucleotidyltransferase-interacting factor 1", "protein_names_refseq": "deoxynucleotidyltransferase terminal-interacting protein 1; tdIF1; tdT-interacting factor 1; terminal deoxynucleotidyltransferase-interacting factor 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:76233); (R-MMU-9764725)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11473582;18849567;21750661;25428506;34075040;35341968", "class_list": "", "function": "Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0042803 protein homodimerization activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61663-1", "uniprot_id": [ { "id": "TLX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61663", "type": "external" } ], "mass": 30361.0, "length": 284, "protein_name": "T-cell leukemia homeobox protein 2", "gene_name": "Tlx2", "organism": "Mouse", "refseq_name": "T-cell leukemia homeobox protein 2", "refseq_ac": [ { "id": "NP_033418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033418", "type": "external" } ], "gene_names_uniprotkb": "Tlx2; Enx; Hox11l1; Ncx; Tlx1l1", "gene_names_refseq": "Enx; Hox11L.1; Hox11l1; NCX; Ncx1; Tlx1l1; Tlx1l2; Tlx2", "protein_names_uniprotkb": "T-cell leukemia homeobox protein 2; Enteric neuron homeobox protein; Homeobox TLX-2; Homeobox protein Hox-11L1; Hox11L.1; PMUR10F", "protein_names_refseq": "PMUR10F; T-cell leukemia homeobox protein 2; enteric neuron homeobox protein; homeo box 11-like 1; homeobox TLX-2; homeobox protein Hox-11L1", "tax_id": 10090, "disease": "intestinal pseudo-obstruction (Disease Ontology:DOID:0080072)", "pathway": " (mmu:21909)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10869550;11176528;15185227;15803212;1681546;17560225;19697050;20682252;21750661;9176491", "class_list": "", "function": "Ncx participates in normal developmental cell death of enteric neurons. Ncx may modulate, if not directly target, expression of the caspase-3 at the transcriptional level to participate in neuronal cell death in the enteric nervous system., [RefSeq, PubMed]; These results suggest that high subsarcolemmal Ca2+ is required to ensure synchronous triggering with short spark latency in the absence of NCX., [RefSeq, PubMed]; Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RR62", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050774 negative regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q61663-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19221-1", "uniprot_id": [ { "id": "THRB_MOUSE", "url": "https://www.uniprot.org/uniprot/P19221", "type": "external" } ], "mass": 70269.0, "length": 618, "protein_name": "Prothrombin", "gene_name": "F2", "organism": "Mouse", "refseq_name": "prothrombin preproprotein", "refseq_ac": [ { "id": "NP_034298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034298", "type": "external" } ], "gene_names_uniprotkb": "F2; Cf2", "gene_names_refseq": "Cf-2; Cf2; F2; FII", "protein_names_uniprotkb": "Prothrombin; 3.4.21.5; Coagulation factor II", "protein_names_refseq": "prothrombin preproprotein; prothrombin; thrombin", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); left ventricular failure (Disease Ontology:DOID:0051064); thrombosis (Disease Ontology:DOID:0060903); COVID-19 (Disease Ontology:DOID:0080600); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); acquired angioedema (Disease Ontology:DOID:0080941); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); sensorineural hearing loss (Disease Ontology:DOID:10003); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); portal vein thrombosis (Disease Ontology:DOID:11695); factor VIII deficiency (Disease Ontology:DOID:12134); Chagas disease (Disease Ontology:DOID:12140); dengue disease (Disease Ontology:DOID:12205); hemophilia B (Disease Ontology:DOID:12259); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Huntington's disease (Disease Ontology:DOID:12858); carotid stenosis (Disease Ontology:DOID:13001); toxic shock syndrome (Disease Ontology:DOID:14115); hereditary angioedema (Disease Ontology:DOID:14735); urticaria (Disease Ontology:DOID:1555); retinal vein occlusion (Disease Ontology:DOID:1727); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); autoimmune hepatitis (Disease Ontology:DOID:2048); prothrombin deficiency (Disease Ontology:DOID:2235); leptospirosis (Disease Ontology:DOID:2297); ovarian cancer (Disease Ontology:DOID:2394); thrombophilia (Disease Ontology:DOID:2452); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); allergic rhinitis (Disease Ontology:DOID:4481); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); appendicitis (Disease Ontology:DOID:8337); bullous pemphigoid (Disease Ontology:DOID:8506); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:14061); (R-MMU-159740); (R-MMU-159763); (R-MMU-159782); (R-MMU-202733); (R-MMU-375276); (R-MMU-416476); (R-MMU-456926); (R-MMU-76009); (R-MMU-9769733); (R-MMU-9769735); (R-MMU-9769739); (R-MMU-9769743); (R-MMU-977606)", "pathway_count": 14, "publication_count": 17, "publication_id_list": "10.1101/2023.09.13.557529;1557383;17330941;17428793;17606903;21750661;2222810;26495903;26740625;31219806;33720950;34428180;36724509;37309666;37507081;37511175;39627609", "class_list": "", "function": "Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]., [RefSeq]; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (By similarity). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thrombin-Induced Microglia Activation Modulated through Aryl Hydrocarbon Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Thrombin-activated interleukin-1alpha drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production. Erratum:[Cardiovasc Res. 2024 Feb 27;120(1):121. doi: 10.1093/cvr/cvad128. PMID: 37607022], [RefSeq, PubMed]; Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 63, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.4.21.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.27", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane;GO:1905370 serine-type endopeptidase complex;GO:0005576 extracellular region", "go_biological_process": "GO:0070945 neutrophil-mediated killing of gram-negative bacterium;GO:0006508 proteolysis;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P19221-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08523-1", "uniprot_id": [ { "id": "TECTA_MOUSE", "url": "https://www.uniprot.org/uniprot/O08523", "type": "external" } ], "mass": 239433.0, "length": 2155, "protein_name": "Alpha-tectorin", "gene_name": "Tecta", "organism": "Mouse", "refseq_name": "alpha-tectorin isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001311477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311477", "type": "external" } ], "gene_names_uniprotkb": "Tecta", "gene_names_refseq": "Tctna; Tecta", "protein_names_uniprotkb": "Alpha-tectorin", "protein_names_refseq": "[a]-tectorin; alpha-tectorin isoform 2 preproprotein; alpha-tectorin", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 21 (Disease Ontology:DOID:0110479); autosomal dominant nonsyndromic deafness 12 (Disease Ontology:DOID:0110544); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (mmu:21683); (R-MMU-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;25080593;9079715;9590290", "class_list": "", "function": "One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals., [UniProtKB]", "predicted_glycosites": 30, "predicted_n_glycosites": 29, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 9462, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 33, "binding_glycan_count": 0, "secondary_ac_list": "E9QNR3", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08523-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08710-1", "uniprot_id": [ { "id": "THYG_MOUSE", "url": "https://www.uniprot.org/uniprot/O08710", "type": "external" } ], "mass": 304473.0, "length": 2766, "protein_name": "Thyroglobulin", "gene_name": "Tg", "organism": "Mouse", "refseq_name": "thyroglobulin precursor", "refseq_ac": [ { "id": "NP_033401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033401", "type": "external" } ], "gene_names_uniprotkb": "Tg; Tgn", "gene_names_refseq": "Tgn; Tg; cog", "protein_names_uniprotkb": "Thyroglobulin; Tg", "protein_names_refseq": "congenital goiter; thyroglobulin precursor", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); thyroid dyshormonogenesis 3 (Disease Ontology:DOID:0112187); goiter (Disease Ontology:DOID:12176); Graves' disease (Disease Ontology:DOID:12361); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); hypothyroidism (Disease Ontology:DOID:1459); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": " (mmu:21819)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12782676;19276074;21750661;30084848;3803305;9344706;9707574", "class_list": "", "function": "Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). One dimer produces 7 thyroid hormone molecules (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 20, "predicted_n_glycosites": 20, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "O88590;Q2NKY1;Q9QWY7", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "GO:0030878 thyroid gland development;GO:0009268 response to pH;GO:0042446 hormone biosynthetic process;GO:0015705 iodide transport;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08710-1", "record_type": "protein", "filter_code": "0000000.1100111.001000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35714-1", "uniprot_id": [ { "id": "TNR18_MOUSE", "url": "https://www.uniprot.org/uniprot/O35714", "type": "external" } ], "mass": 25334.0, "length": 228, "protein_name": "Tumor necrosis factor receptor superfamily member 18", "gene_name": "Tnfrsf18", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 18 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033426", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf18; Gitr", "gene_names_refseq": "AITR; Gitr; Tnfrsf18", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 18; Glucocorticoid-induced TNFR-related protein", "protein_names_refseq": "glucocorticoid-induced TNFR-related protein; tumor necrosis factor receptor superfamily member 18 isoform 1 precursor", "tax_id": 10090, "disease": "anogenital venereal wart (Disease Ontology:DOID:11168); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321)", "pathway": " (mmu:21936); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10798444;10836847;11869690;12478477;21750661;25605945;34293591;34418432;35880612;9177197", "class_list": "", "function": "A functional role for this receptor in regulating the CD4+CD25+ T cell subset., [RefSeq, PubMed]; Blockade of GITRL/GITR signaling pathway attenuates house dust mite-induced allergic asthma in mice through inhibition of MAPKs and NF-kappaB signaling., [RefSeq, PubMed]; GITR agonistic stimulation enhances the anti-tumor immune response in a mouse model of ESCC., [RefSeq, PubMed]; Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR., [RefSeq, PubMed]; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKR1;Q9JKR2;Q9JKR3", "ec_number_list": [], "go_molecular_function": "GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion;GO:0006915 apoptotic process;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0002687 positive regulation of leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35714-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88346-1", "uniprot_id": [ { "id": "TNNT1_MOUSE", "url": "https://www.uniprot.org/uniprot/O88346", "type": "external" } ], "mass": 31344.0, "length": 262, "protein_name": "Troponin T, slow skeletal muscle", "gene_name": "Tnnt1", "organism": "Mouse", "refseq_name": "troponin T, slow skeletal muscle isoform 1", "refseq_ac": [ { "id": "NP_001264832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264832", "type": "external" } ], "gene_names_uniprotkb": "Tnnt1", "gene_names_refseq": "Tnnt1; Tnt; sTnT; ssTnT", "protein_names_uniprotkb": "Troponin T, slow skeletal muscle; Slow skeletal muscle troponin T; TnTs; sTnT", "protein_names_refseq": "skeletal muscle slow-twitch TnT; troponin T, slow skeletal muscle isoform 1; troponin T, slow skeletal muscle", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); nemaline myopathy 5B (Disease Ontology:DOID:0081374); nemaline myopathy 5C (Disease Ontology:DOID:0081375); nemaline myopathy 5A (Disease Ontology:DOID:0110936); nemaline myopathy (Disease Ontology:DOID:3191)", "pathway": " (mmu:21955); (R-MMU-390522)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10095098;11003710;21750661;25605945;9651500", "class_list": "", "function": "This gene encodes the slow skeletal tropomyosin-binding subunit of the troponin complex and plays an essential role in the regulation of striated muscle contraction. In humans, mutations in this gene are associated with nemaline myopathy type 5. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7ZNV5;B7ZNV6;O88795;Q9QUP7", "ec_number_list": [], "go_molecular_function": "GO:0031014 troponin T binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0014883 transition between fast and slow fiber;GO:0045214 sarcomere organization;GO:0031444 slow-twitch skeletal muscle fiber contraction;GO:0045932 negative regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88346-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32972-1", "uniprot_id": [ { "id": "TNFL8_MOUSE", "url": "https://www.uniprot.org/uniprot/P32972", "type": "external" } ], "mass": 26519.0, "length": 239, "protein_name": "Tumor necrosis factor ligand superfamily member 8", "gene_name": "Tnfsf8", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 8", "refseq_ac": [ { "id": "NP_033429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033429", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf8; Cd30lg; Cd30l", "gene_names_refseq": "CD153; CD30LG; Cd30l; Tnfsf8; Tnlg3a", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L", "protein_names_refseq": "CD30 ligand; CD30-L; tumor necrosis factor ligand 3a; tumor necrosis factor ligand superfamily member 8", "tax_id": 10090, "disease": "", "pathway": " (mmu:21949); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;32424156;34813503;35834956;36130493;8391931", "class_list": "", "function": "CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury., [RefSeq, PubMed]; CD30L is involved in the regulation of the inflammatory response through inducing homing and differentiation of monocytes via CCL2/CCR2 axis and NF-kappaB pathway in mice with colitis., [RefSeq, PubMed]; Cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells., [RefSeq, PubMed]; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32972-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43025-1", "uniprot_id": [ { "id": "TETN_MOUSE", "url": "https://www.uniprot.org/uniprot/P43025", "type": "external" } ], "mass": 22257.0, "length": 202, "protein_name": "Tetranectin", "gene_name": "Clec3b", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clec3b; Tna", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetranectin; C-type lectin domain family 3 member B; Plasminogen kringle 4-binding protein; TN", "protein_names_refseq": "", "tax_id": 10090, "disease": "retinal macular dystrophy 4 (Disease Ontology:DOID:0070441); Scheuermann's disease (Disease Ontology:DOID:13300); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (R-MMU-114608)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "32152506;35331648;7835708;8563165;9409787", "class_list": "glycogene", "function": "Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity). Plays a role in retinal function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0036143 kringle domain binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0001652 granular component", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:0001501 skeletal system development;GO:0001503 ossification;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P43025-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54797-1", "uniprot_id": [ { "id": "TNG2_MOUSE", "url": "https://www.uniprot.org/uniprot/P54797", "type": "external" } ], "mass": 30874.0, "length": 276, "protein_name": "Transport and Golgi organization 2 homolog", "gene_name": "Tango2", "organism": "Mouse", "refseq_name": "transport and Golgi organization 2 homolog isoform 1", "refseq_ac": [ { "id": "NP_613049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_613049", "type": "external" } ], "gene_names_uniprotkb": "Tango2; D16H22S680E; T10", "gene_names_refseq": "D16H22S680E; T10; Tango2", "protein_names_uniprotkb": "Transport and Golgi organization 2 homolog; Ser/Thr-rich protein T10 in DGCR region", "protein_names_refseq": "ser/Thr-rich protein T10 in DGCR region; transport and Golgi organization 2 homolog isoform 1; transport and golgi organization 2 homolog", "tax_id": 10090, "disease": "TANGO2-related metabolic encephalopathy and arrythmias (Disease Ontology:DOID:0081386)", "pathway": " (mmu:27883)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18775783;21750661;26805782;37507081;8268909", "class_list": "", "function": "May be involved in lipid homeostasis., [UniProtKB, UniProtKB]; Our study suggests TANGO2 deficiency as a differential diagnosis in cases of episodic encephalopathy and/or myopathy in infancy and childhood of unknown cause, especially in individuals with cardiac arrhythmias., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BTN3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P54797-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08189-1", "uniprot_id": [ { "id": "TGM3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08189", "type": "external" } ], "mass": 77309.0, "length": 693, "protein_name": "Protein-glutamine gamma-glutamyltransferase E", "gene_name": "Tgm3", "organism": "Mouse", "refseq_name": "protein-glutamine gamma-glutamyltransferase E isoform 1 precursor", "refseq_ac": [ { "id": "NP_033400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033400", "type": "external" } ], "gene_names_uniprotkb": "Tgm3; Tgase3", "gene_names_refseq": "TG E; TG(E); TGE; TGase E; TGase-3; Tgm3; we", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase E; 2.3.2.13; TG(E); TGE; TGase E; TGase-3; Transglutaminase E; Transglutaminase-3", "protein_names_refseq": "E polypeptide; protein-glutamine gamma-glutamyltransferase E isoform 1 precursor; protein-glutamine gamma-glutamyltransferase E; protein-glutamine-gamma-glutamyltransferase; transglutaminase E; transglutaminase-3", "tax_id": 10090, "disease": "", "pathway": " (mmu:21818)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11331204;15740639;20716179;24788674;34203471;34428180;35545140;8099584", "class_list": "", "function": "Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath., [UniProtKB]; Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by Inhibiting NF-kappaB Activation through Phosphorylated STAT3-TET3 Signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L343;A2ANC3", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005509 calcium ion binding;GO:0003824 catalytic activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0001533 cornified envelope;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0043588 skin development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08189-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08423-1", "uniprot_id": [ { "id": "TFF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08423", "type": "external" } ], "mass": 9670.0, "length": 87, "protein_name": "Trefoil factor 1", "gene_name": "Tff1", "organism": "Mouse", "refseq_name": "trefoil factor 1 precursor", "refseq_ac": [ { "id": "NP_033388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033388", "type": "external" } ], "gene_names_uniprotkb": "Tff1; Bcei; Ps2", "gene_names_refseq": "Bcei; PS2; Tff1", "protein_names_uniprotkb": "Trefoil factor 1; Protein pS2", "protein_names_refseq": "protein pS2; trefoil factor 1 precursor", "tax_id": 10090, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); signet ring cell adenocarcinoma (Disease Ontology:DOID:3493); cervical adenocarcinoma (Disease Ontology:DOID:3702); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (mmu:21784)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11290420;21750661;39197918;8314841", "class_list": "", "function": "Loss of Trefoil Factor 1 Accelerates the Immune Response to Colorectal Cancer., [RefSeq, PubMed]; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVE6", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08423-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2MV57-1", "uniprot_id": [ { "id": "TECT2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q2MV57", "type": "external" } ], "mass": 77111.0, "length": 700, "protein_name": "Tectonic-2", "gene_name": "Tctn2", "organism": "Mouse", "refseq_name": "tectonic-2 precursor", "refseq_ac": [ { "id": "NP_080762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080762", "type": "external" } ], "gene_names_uniprotkb": "Tctn2; Tect2", "gene_names_refseq": "4432405B04Rik; Tctn2; Tect2", "protein_names_uniprotkb": "Tectonic-2", "protein_names_refseq": "tectonic-2 precursor; tectonic-2", "tax_id": 10090, "disease": "Meckel syndrome 8 (Disease Ontology:DOID:0070122); Joubert syndrome 24 (Disease Ontology:DOID:0110993)", "pathway": " (mmu:67978); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16357211;19349973;21462283;21565611;21725307;22179047;36049372", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction., [UniProtKB, PubMed, PubMed, PubMed]; Loss of Tctn2 is associated with ciliopathies. Publication Status: Online-Only, [RefSeq, PubMed]; Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9606, "biomarker_type": "", "glycan_count": 3, "disease_count": 2, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDZ5;Q8C0B3;Q9CXF5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1904491 protein localization to ciliary transition zone", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q2MV57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TQI7-1", "uniprot_id": [ { "id": "TLS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TQI7", "type": "external" } ], "mass": 33544.0, "length": 289, "protein_name": "Splicing factor C9orf78 homolog", "gene_name": "", "organism": "Mouse", "refseq_name": "splicing factor C9orf78 homolog", "refseq_ac": [ { "id": "NP_659134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659134", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "BC005624", "protein_names_uniprotkb": "Splicing factor C9orf78 homolog", "protein_names_refseq": "splicing factor C9orf78 homolog; telomere length and silencing protein 1 homolog; uncharacterized protein C9orf78 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:227707); (R-MMU-72163)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17242355;17947660;19144319;21183079;34428180", "class_list": "", "function": "Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (By similarity). May also modulate exon inclusion events (By similarity). PPlays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (By similarity). Binds U5 snRNA (By similarity). Required for proper chromosome segregation (By similarity). Not required for splicing of shelterin components (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JW3", "ec_number_list": [], "go_molecular_function": "GO:0030623 U5 snRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0060629 regulation of homologous chromosome segregation;GO:0007059 chromosome segregation;GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3TQI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYG6-1", "uniprot_id": [ { "id": "TGRM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYG6", "type": "external" } ], "mass": 108975.0, "length": 1002, "protein_name": "TOG array regulator of axonemal microtubules protein 2", "gene_name": "Togaram2", "organism": "Mouse", "refseq_name": "TOG array regulator of axonemal microtubules protein 2", "refseq_ac": [ { "id": "NP_796061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796061", "type": "external" } ], "gene_names_uniprotkb": "Togaram2; Fam179a", "gene_names_refseq": "4632412N22Rik; Fam179a; Togaram2", "protein_names_uniprotkb": "TOG array regulator of axonemal microtubules protein 2; Crescerin-2; Protein FAM179A", "protein_names_refseq": "TOG array regulator of axonemal microtubules protein 2; crescerin-2; family with sequence similarity 179, member A; protein FAM179A", "tax_id": 10090, "disease": "ciliopathy (Disease Ontology:DOID:0060340)", "pathway": " (mmu:320159)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;26378256;29187734;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C7B2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005929 cilium;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TYG6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U132-1", "uniprot_id": [ { "id": "TESP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U132", "type": "external" } ], "mass": 51768.0, "length": 458, "protein_name": "Protein TESPA1", "gene_name": "Tespa1", "organism": "Mouse", "refseq_name": "protein TESPA1 isoform a", "refseq_ac": [ { "id": "NP_899087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899087", "type": "external" } ], "gene_names_uniprotkb": "Tespa1", "gene_names_refseq": "5830405N20Rik; A430001F24Rik; Itprid3; Tespa1", "protein_names_uniprotkb": "Protein TESPA1; Thymocyte-expressed positive selection-associated protein 1", "protein_names_refseq": "protein TESPA1 isoform a; protein TESPA1; thymocyte-expressed positive selection-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67596)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21183079;22561606;23541577;23650607;25422497;28598420;29867947;31316154;33228696;34428180;36997676", "class_list": "", "function": "Loss of Tespa1 in mouse mast cells led to hyper-responsiveness to stimulation via FcepsilonRI., [RefSeq, PubMed]; May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes., [UniProtKB, PubMed]; Our study demonstrates that Tespa1 is essential for T cell-dependent B cell responses, and suggests an important role for Tespa1 during the development of autoimmune arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation., [RefSeq, PubMed]; Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1 Erratum:[Nat Commun. 2018 Mar 12;9:16183. doi: 10.1038/ncomms16183. PMID: 29528040] Publication Status: Online-Only, [RefSeq, PubMed]; Tespa1 is a component of the TCR signalosome and is essential for T-cell selection and maturation through regulation of TCR signaling during T-cell development. Publication Status: Online-Only, [RefSeq, PubMed]; Tespa1 is post-translationally modified upon intracellular Ca2+ increase in thymocytes., [RefSeq, PubMed]; Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Thymic-specific regulation of TCR signaling by Tespa1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TR68;Q8CEN9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0008180 COP9 signalosome;GO:0036398 TCR signalosome", "go_biological_process": "GO:0033089 positive regulation of T cell differentiation in thymus;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0008104 intracellular protein localization;GO:0010387 COP9 signalosome assembly;GO:0036399 TCR signalosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q3U132-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UME2-1", "uniprot_id": [ { "id": "S35D4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UME2", "type": "external" } ], "mass": 32965.0, "length": 297, "protein_name": "UDP-N-acetylglucosamine transporter SLC35D4", "gene_name": "Slc35d4; Tmem241", "organism": "Mouse", "refseq_name": "UDP-N-acetylglucosamine transporter SLC35D4 isoform 1", "refseq_ac": [ { "id": "NP_001276595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276595", "type": "external" } ], "gene_names_uniprotkb": "Slc35d4; Tmem241; Tmem241", "gene_names_refseq": "6030446N20Rik; Gprasp3; Slc35d4; Tmem241", "protein_names_uniprotkb": "UDP-N-acetylglucosamine transporter SLC35D4; Solute carrier family 35 member D4; Transmembrane protein 241", "protein_names_refseq": "UDP-N-acetylglucosamine transporter SLC35D4 isoform 1; UDP-N-acetylglucosamine transporter SLC35D4; UDP-N-acetylglucosamine transporter TMEM241; solute carrier family 35 member D4; transmembrane protein 241; transmembrane protein C18orf45 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:338363)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;35953472;37890669", "class_list": "", "function": "Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Golgi-localized UDP-N-acetylglucosamine (UDP-GlcNAc) transporter that transports UDP-N-acetylglucosamine into Golgi lumen. Contributes to lysosomal targeting of NPC2, a key protein required for lysosomal cholesterol exiting, and that utilizes the mannose-6-phosphate (M6P) modification pathway for its lysosomal targeting., [UniProtKB, UniProtKB]; TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ16;Q8CAM4;Q8CAM9;Q8CD42", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005458 GDP-mannose transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:1990570 GDP-mannose transmembrane transport;GO:1990569 UDP-N-acetylglucosamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UME2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V0Q7-1", "uniprot_id": [ { "id": "TMPSC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V0Q7", "type": "external" } ], "mass": 36916.0, "length": 336, "protein_name": "Transmembrane protease serine 12", "gene_name": "Tmprss12", "organism": "Mouse", "refseq_name": "transmembrane protease serine 12 isoform 1 precursor", "refseq_ac": [ { "id": "NP_898932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898932", "type": "external" } ], "gene_names_uniprotkb": "Tmprss12", "gene_names_refseq": "4930478A21Rik; Tmprss12", "protein_names_uniprotkb": "Transmembrane protease serine 12; 3.4.21.-", "protein_names_refseq": "transmembrane protease serine 12 isoform 1 precursor; transmembrane protease serine 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:75002)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32529245;35547804", "class_list": "", "function": "Required for male fertility (PubMed:32529245, PubMed:35547804). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (PubMed:35547804). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (PubMed:35547804). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (PubMed:32529245)., [UniProtKB, PubMed, PubMed]; Tmprss12 is required for sperm motility and uterotubal junction migration in micedagger., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007339 binding of sperm to zona pellucida;GO:0016485 protein processing;GO:0001675 acrosome assembly;GO:1902492 positive regulation of sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3V0Q7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A06-1", "uniprot_id": [ { "id": "TMTC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q56A06", "type": "external" } ], "mass": 94176.0, "length": 836, "protein_name": "Protein O-mannosyl-transferase TMTC2", "gene_name": "Tmtc2", "organism": "Mouse", "refseq_name": "protein O-mannosyl-transferase TMTC2 precursor", "refseq_ac": [ { "id": "NP_796342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796342", "type": "external" } ], "gene_names_uniprotkb": "Tmtc2", "gene_names_refseq": "8430438D04Rik; D330034A10Rik; Tmtc2", "protein_names_uniprotkb": "Protein O-mannosyl-transferase TMTC2; 2.4.1.109; Transmembrane O-mannosyltransferase targeting cadherins 2; Transmembrane and tetratricopeptide repeat-containing 2", "protein_names_refseq": "protein O-mannosyl-transferase TMTC2 precursor; protein O-mannosyl-transferase TMTC2; transmembrane O-mannosyltransferase targeting cadherins 2; transmembrane and TPR repeat-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:278279)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RRD8;Q5U620;Q8C787", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055074 calcium ion homeostasis;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q56A06-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SYH2-1", "uniprot_id": [ { "id": "VMA12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SYH2", "type": "external" } ], "mass": 23099.0, "length": 208, "protein_name": "Vacuolar ATPase assembly protein VMA12", "gene_name": "Vma12", "organism": "Mouse", "refseq_name": "vacuolar ATPase assembly protein VMA12", "refseq_ac": [ { "id": "NP_954669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954669", "type": "external" } ], "gene_names_uniprotkb": "Vma12; Tmem199", "gene_names_refseq": "Tmem199; Vma12", "protein_names_uniprotkb": "Vacuolar ATPase assembly protein VMA12; Transmembrane protein 199", "protein_names_refseq": "RE40914p; transmembrane protein 199; vacuolar ATPase assembly protein VMA12", "tax_id": 10090, "disease": "congenital disorder of glycosylation type IIp (Disease Ontology:DOID:0070268)", "pathway": " (mmu:195040)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "19224205;19892989;20173027;25428506;25428507;25605945;27802388;30084848;30779550;31219806;31599954;33649389;34428180;34799735;35820727", "class_list": "", "function": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007042 lysosomal lumen acidification;GO:0036295 cellular response to increased oxygen levels;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q5SYH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62264-1", "uniprot_id": [ { "id": "THRSP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62264", "type": "external" } ], "mass": 17093.0, "length": 150, "protein_name": "Thyroid hormone-inducible hepatic protein", "gene_name": "Thrsp", "organism": "Mouse", "refseq_name": "thyroid hormone-inducible hepatic protein", "refseq_ac": [ { "id": "NP_033407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033407", "type": "external" } ], "gene_names_uniprotkb": "Thrsp; S14", "gene_names_refseq": "S14; SPOT14; Thrsp", "protein_names_uniprotkb": "Thyroid hormone-inducible hepatic protein; S14; SPOT14; Spot 14 protein", "protein_names_refseq": "spot 14 protein; thyroid hormone responsive SPOT14 homolog; thyroid hormone-inducible hepatic protein", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:21835); (R-MMU-200425)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11564699;15890771;19356628;20952656;34428180;34545202;36210013;9003802", "class_list": "", "function": "Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity)., [UniProtKB, PubMed, PubMed]; Spot 14 protein, absent in the lactating mammary gland, is required for maximum efficiency of de novo lipid synthesis in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process;GO:0009617 response to bacterium;GO:0046890 regulation of lipid biosynthetic process;GO:0010866 regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62314-1", "uniprot_id": [ { "id": "TGON2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62314", "type": "external" } ], "mass": 38821.0, "length": 363, "protein_name": "Trans-Golgi network integral membrane protein 2", "gene_name": "Tgoln2", "organism": "Mouse", "refseq_name": "trans-Golgi network integral membrane protein 2 precursor", "refseq_ac": [ { "id": "NP_033470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033470", "type": "external" } ], "gene_names_uniprotkb": "Tgoln2; Ttgn2", "gene_names_refseq": "TGN38B; TGN41; TGN46; Tgoln2; Ttgn2", "protein_names_uniprotkb": "Trans-Golgi network integral membrane protein 2; TGN38B", "protein_names_refseq": "trans-Golgi network integral membrane protein 2 precursor; trans-Golgi network integral membrane protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:22135)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16075062;17242355;18250455;26495903;28011936;7540170", "class_list": "", "function": "May be involved in regulating membrane traffic to and from trans-Golgi network., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFE7-1", "uniprot_id": [ { "id": "TEFF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFE7", "type": "external" } ], "mass": 40114.0, "length": 372, "protein_name": "Tomoregulin-1", "gene_name": "Tmeff1", "organism": "Mouse", "refseq_name": "tomoregulin-1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_067411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067411", "type": "external" } ], "gene_names_uniprotkb": "Tmeff1", "gene_names_refseq": "A830033E11; M7365; TR-1; Tmeff1; Tr1", "protein_names_uniprotkb": "Tomoregulin-1; M7365; TR-1; Transmembrane protein with EGF-like and one follistatin-like domain", "protein_names_refseq": "tomoregulin-1 isoform 2 precursor; tomoregulin-1; transmembrane protein with EGF-like and one follistatin-like domain", "tax_id": 10090, "disease": "", "pathway": " (mmu:230157)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1101/2023.09.13.557529;11025219;11165370;11404089;21750661;26092120;30899004;33300544;35020881;39048823", "class_list": "", "function": "A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC-induced cardiac hypertrophy is through inhibiting TGFbeta non-canonical (TAK1-JNK) pathways in the myocardium., [RefSeq, PubMed]; Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry (PubMed:39048823). Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent (By similarity). Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane (By similarity). Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving., [RefSeq, PubMed]; TMEFF1 is a neuron-specific restriction factor for herpes simplex virus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AJN3;Q8BRP7;Q8C536;Q9JJS1", "ec_number_list": [], "go_molecular_function": "GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046597 host-mediated suppression of symbiont invasion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6PFE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UB0-1", "uniprot_id": [ { "id": "TEST2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80UB0", "type": "external" } ], "mass": 38090.0, "length": 333, "protein_name": "Testin-2", "gene_name": "", "organism": "Mouse", "refseq_name": "testin-2 precursor", "refseq_ac": [ { "id": "NP_835199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835199", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4930486L24Rik", "protein_names_uniprotkb": "Testin-2", "protein_names_refseq": "testin-2 precursor; testin-2; testin", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (mmu:214639)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12606342;25428506", "class_list": "", "function": "Within proximal promoter region three closely spaced putative binding sites for GATA, sex-determining factor, and steroidogenic factor 1 that are important for testin gene transcription in mouse Sertoli cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UKN7", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030054 cell junction;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80UB0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XA0-1", "uniprot_id": [ { "id": "TM121_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80XA0", "type": "external" } ], "mass": 35684.0, "length": 318, "protein_name": "Transmembrane protein 121", "gene_name": "Tmem121", "organism": "Mouse", "refseq_name": "transmembrane protein 121", "refseq_ac": [ { "id": "NP_722471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722471", "type": "external" } ], "gene_names_uniprotkb": "Tmem121; Hole", "gene_names_refseq": "2410008J05Rik; Hole; Tmem121", "protein_names_uniprotkb": "Transmembrane protein 121; Protein hole", "protein_names_refseq": "protein hole; transmembrane protein 121", "tax_id": 10090, "disease": "", "pathway": " (mmu:69195)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12204283", "class_list": "", "function": "May play a role in MAPK signaling., [UniProtKB]; Mouse hole is not expressed in the developing heart, although it does share neural expression seen in the chick., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3W8;Q8R4A5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80XA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH26-1", "uniprot_id": [ { "id": "LYSET_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH26", "type": "external" } ], "mass": 18720.0, "length": 163, "protein_name": "Lysosomal enzyme trafficking factor", "gene_name": "Lyset", "organism": "Mouse", "refseq_name": "lysosomal enzyme trafficking factor isoform 1", "refseq_ac": [ { "id": "NP_796114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796114", "type": "external" } ], "gene_names_uniprotkb": "Lyset; C14orf109; Tmem251", "gene_names_refseq": "D230037D09Rik; Lyset; Tmem251", "protein_names_uniprotkb": "Lysosomal enzyme trafficking factor; Transmembrane protein 251", "protein_names_refseq": "UPF0694 transmembrane protein C14orf109 homolog; lysosomal enzyme trafficking factor isoform 1; transmembrane protein 251", "tax_id": 10090, "disease": "mucolipidosis (Disease Ontology:DOID:0080488)", "pathway": " (mmu:320351)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "36074821;36074822;36096887", "class_list": "", "function": "GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (By similarity). Plays an essential function for cells that depend on lysosomal catabolism to generate nutrients (PubMed:36074821)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0009615 response to virus;GO:0050790 regulation of catalytic activity;GO:0007040 lysosome organization;GO:0031647 regulation of protein stability;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BH26-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BMQ2-1", "uniprot_id": [ { "id": "TF3C4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BMQ2", "type": "external" } ], "mass": 91613.0, "length": 817, "protein_name": "General transcription factor 3C polypeptide 4", "gene_name": "Gtf3c4", "organism": "Mouse", "refseq_name": "general transcription factor 3C polypeptide 4 isoform 2", "refseq_ac": [ { "id": "NP_001159505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159505", "type": "external" } ], "gene_names_uniprotkb": "Gtf3c4", "gene_names_refseq": "5330400C03; Gtf3c4; KAT12; TFIIIC90", "protein_names_uniprotkb": "General transcription factor 3C polypeptide 4; 2.3.1.48; TF3C-delta; TFIIIC 90 kDa subunit; TFIIIC90; Transcription factor IIIC 90 kDa subunit; Transcription factor IIIC subunit delta", "protein_names_refseq": "TF3C-delta; TFIIIC 90 kDa subunit; general transcription factor 3C polypeptide 4 isoform 2; general transcription factor 3C polypeptide 4; general transcription factor IIIC 4; transcription factor IIIC 90 kDa subunit; transcription factor IIIC subunit delta", "tax_id": 10090, "disease": "", "pathway": " (mmu:269252); (R-MMU-76061); (R-MMU-76066)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;31219806;31599954", "class_list": "", "function": "Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148Y1;Q8BKZ4", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0000995 RNA polymerase III general transcription initiation factor activity;GO:0036408 histone H3K14 acetyltransferase activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0000127 transcription factor TFIIIC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BMQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQU7-1", "uniprot_id": [ { "id": "TMM74_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQU7", "type": "external" } ], "mass": 33416.0, "length": 305, "protein_name": "Transmembrane protein 74", "gene_name": "Tmem74", "organism": "Mouse", "refseq_name": "transmembrane protein 74", "refseq_ac": [ { "id": "NP_780711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780711", "type": "external" } ], "gene_names_uniprotkb": "Tmem74", "gene_names_refseq": "B230382K22Rik; Tmem74", "protein_names_uniprotkb": "Transmembrane protein 74", "protein_names_refseq": "transmembrane protein 74", "tax_id": 10090, "disease": "", "pathway": " (mmu:239408)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;25428506", "class_list": "", "function": "Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0016236 macroautophagy;GO:0051867 general adaptation syndrome, behavioral process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BQU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BZ64-1", "uniprot_id": [ { "id": "TECT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BZ64", "type": "external" } ], "mass": 63447.0, "length": 593, "protein_name": "Tectonic-1", "gene_name": "Tctn1", "organism": "Mouse", "refseq_name": "tectonic-1 precursor", "refseq_ac": [ { "id": "NP_001034242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034242", "type": "external" } ], "gene_names_uniprotkb": "Tctn1; Tect1", "gene_names_refseq": "4930565B19Rik; G730031O11Rik; Tctn1; Tect1", "protein_names_uniprotkb": "Tectonic-1", "protein_names_refseq": "tectonic-1 precursor; tectonic-1", "tax_id": 10090, "disease": "Joubert syndrome 13 (Disease Ontology:DOID:0110982)", "pathway": " (mmu:654470); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;16357211;21565611;21725307;21750661;22179047;24129315;28800946;31219806", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23., [UniProtKB, PubMed, PubMed, PubMed]; During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Tectonic plays an additional role in repressing Hh pathway activity., [RefSeq, PubMed]; These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMP0;Q8BUE2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0021956 central nervous system interneuron axonogenesis;GO:0001701 in utero embryonic development;GO:0060271 cilium assembly;GO:0008589 regulation of smoothened signaling pathway;GO:1904491 protein localization to ciliary transition zone", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BZ64-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGF5-1", "uniprot_id": [ { "id": "TLCD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CGF5", "type": "external" } ], "mass": 31236.0, "length": 276, "protein_name": "TLC domain-containing protein 4", "gene_name": "Tlcd4", "organism": "Mouse", "refseq_name": "TLC domain-containing protein 4 isoform X1", "refseq_ac": [ { "id": "XP_006502541", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006502541", "type": "external" } ], "gene_names_uniprotkb": "Tlcd4; Tmem56", "gene_names_refseq": "4930577M16Rik; C730036B01Rik; Tlcd4; Tmem56", "protein_names_uniprotkb": "TLC domain-containing protein 4; Transmembrane protein 56", "protein_names_refseq": "TLC domain-containing protein 4 isoform X1", "tax_id": 10090, "disease": "", "pathway": " (mmu:99887)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4Q8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CGF5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIB6-1", "uniprot_id": [ { "id": "TM230_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8CIB6", "type": "external" } ], "mass": 13188.0, "length": 120, "protein_name": "Transmembrane protein 230", "gene_name": "Tmem230", "organism": "Mouse", "refseq_name": "transmembrane protein 230", "refseq_ac": [ { "id": "NP_001135443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135443", "type": "external" } ], "gene_names_uniprotkb": "Tmem230", "gene_names_refseq": "5730494N06Rik; Tmem230", "protein_names_uniprotkb": "Transmembrane protein 230", "protein_names_refseq": "UPF0414 transmembrane protein C20orf30 homolog; transmembrane protein 230", "tax_id": 10090, "disease": "", "pathway": " (mmu:70612)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15345747;17242355;18630941;19144319;21183079;27270108", "class_list": "", "function": "Involved in trafficking and recycling of synaptic vesicles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYF7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0055037 recycling endosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0048489 synaptic vesicle transport;GO:0098930 axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CIB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZM0-1", "uniprot_id": [ { "id": "TFB1M_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZM0", "type": "external" } ], "mass": 38962.0, "length": 345, "protein_name": "Dimethyladenosine transferase 1, mitochondrial", "gene_name": "Tfb1m", "organism": "Mouse", "refseq_name": "dimethyladenosine transferase 1, mitochondrial", "refseq_ac": [ { "id": "NP_666186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666186", "type": "external" } ], "gene_names_uniprotkb": "Tfb1m", "gene_names_refseq": "Tfb1m; mtTFB1", "protein_names_uniprotkb": "Dimethyladenosine transferase 1, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; mtTFB1", "protein_names_refseq": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; dimethyladenosine transferase 1, mitochondrial; mitochondrial 12S rRNA dimethylase 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:224481)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12068295;12532263;19356719;23804760;35676484", "class_list": "", "function": "Metazoans have two TFBM genes, suggesting that a duplication of the gene has permitted a more flexible regulation of mtDNA., [RefSeq, PubMed]; Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1006 and A1007) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:19356719). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8JZM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZM6-1", "uniprot_id": [ { "id": "TIFAB_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZM6", "type": "external" } ], "mass": 16636.0, "length": 147, "protein_name": "TRAF-interacting protein with FHA domain-containing protein B", "gene_name": "Tifab", "organism": "Mouse", "refseq_name": "TRAF-interacting protein with FHA domain-containing protein B", "refseq_ac": [ { "id": "NP_001162086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162086", "type": "external" } ], "gene_names_uniprotkb": "Tifab", "gene_names_refseq": "Tifab", "protein_names_uniprotkb": "TRAF-interacting protein with FHA domain-containing protein B; TIFA-like protein", "protein_names_refseq": "TIFA like protein; TIFA related protein TIFAB; TRAF-interacting protein with FHA domain-containing protein B", "tax_id": 10090, "disease": "", "pathway": " (mmu:212937)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15047173;19470519;26458771;26944478", "class_list": "", "function": "Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA., [UniProtKB, PubMed]; Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms, [RefSeq, PubMed]; Study shows TIFAB is mainly expressed in B cells rather than T cells in the spleen; results suggest TIFAB could act as a negative regulator of TRAF6-induced cellular function such as B cell proliferation and maturation of dendritic cellss & macrophages, [RefSeq, PubMed]; TIFAB loss increases TRAF6 protein and the dynamic range of TLR4 signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q05DP7;Q571I3", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:1990381 ubiquitin-specific protease binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0048806 genitalia development;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8JZM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R235-1", "uniprot_id": [ { "id": "TM203_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R235", "type": "external" } ], "mass": 15776.0, "length": 136, "protein_name": "Transmembrane protein 203", "gene_name": "Tmem203", "organism": "Mouse", "refseq_name": "transmembrane protein 203", "refseq_ac": [ { "id": "NP_796318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796318", "type": "external" } ], "gene_names_uniprotkb": "Tmem203", "gene_names_refseq": "C730025P13Rik; Hbebp1; Tmem203", "protein_names_uniprotkb": "Transmembrane protein 203", "protein_names_refseq": "HBeAg-binding protein 1; transmembrane protein 203", "tax_id": 10090, "disease": "", "pathway": " (mmu:227615)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25996873;30084848;31346090", "class_list": "", "function": "Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873). Acts as a regulator of STING-mediated inflammatory signaling in macrophages (PubMed:31346090). Forms a complex with STING, promoting the activity of TBK1 kinase and the transcription factor IRF3, leading to activation of type I interferon expression (PubMed:31346090)., [UniProtKB, PubMed, PubMed]; Tmem203 is an evolutionarily conserved regulator of cellular calcium homeostasis, is required for spermatogenesis and provides a causal link between intracellular calcium regulation and spermiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BQ59", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R235-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Q6-1", "uniprot_id": [ { "id": "TECT3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Q6", "type": "external" } ], "mass": 64824.0, "length": 595, "protein_name": "Tectonic-3", "gene_name": "Tctn3", "organism": "Mouse", "refseq_name": "tectonic-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_080536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080536", "type": "external" } ], "gene_names_uniprotkb": "Tctn3; Tect3", "gene_names_refseq": "4930521E07Rik; Tctn3; Tect3", "protein_names_uniprotkb": "Tectonic-3", "protein_names_refseq": "tectonic-3 isoform 1 precursor; tectonic-3", "tax_id": 10090, "disease": "orofaciodigital syndrome IV (Disease Ontology:DOID:0060374); Joubert syndrome 18 (Disease Ontology:DOID:0110987)", "pathway": " (mmu:67590); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;16357211;21565611;21725307;21750661;28800946;29725084;34428180", "class_list": "", "function": "Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway., [UniProtKB, PubMed]; Results show that Tctn3 KO disrupts the Shh signaling pathway and neural tube patterning, resulting in abnormal embryonic development, cellular apoptosis, and prenatal death in mice. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9671, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8CDF3;Q9CRC5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R2Q6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCR3-1", "uniprot_id": [ { "id": "TM242_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCR3", "type": "external" } ], "mass": 14916.0, "length": 140, "protein_name": "Transmembrane protein 242", "gene_name": "Tmem242", "organism": "Mouse", "refseq_name": "transmembrane protein 242", "refseq_ac": [ { "id": "NP_081733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081733", "type": "external" } ], "gene_names_uniprotkb": "Tmem242", "gene_names_refseq": "1110008A10Rik; 2310046K16Rik; 5730437N04Rik; Tmem242", "protein_names_uniprotkb": "Transmembrane protein 242", "protein_names_refseq": "UPF0463 transmembrane protein C6orf35 homolog; transmembrane protein 242", "tax_id": 10090, "disease": "", "pathway": " (mmu:70544)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2T2;Q8CEX9;Q9CYJ2;Q9D1H4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VCR3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VE80-1", "uniprot_id": [ { "id": "THOC3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VE80", "type": "external" } ], "mass": 38738.0, "length": 351, "protein_name": "THO complex subunit 3", "gene_name": "Thoc3", "organism": "Mouse", "refseq_name": "THO complex subunit 3", "refseq_ac": [ { "id": "NP_082873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082873", "type": "external" } ], "gene_names_uniprotkb": "Thoc3", "gene_names_refseq": "2410044K02Rik; Thoc3", "protein_names_uniprotkb": "THO complex subunit 3; Tho3", "protein_names_refseq": "THO complex subunit 3; tho3", "tax_id": 10090, "disease": "", "pathway": " (mmu:73666); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA and spliced mRNA. The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CWI8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000445 THO complex part of transcription export complex;GO:0000346 transcription export complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VE80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W18-1", "uniprot_id": [ { "id": "TDRD3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W18", "type": "external" } ], "mass": 82253.0, "length": 743, "protein_name": "Tudor domain-containing protein 3", "gene_name": "Tdrd3", "organism": "Mouse", "refseq_name": "tudor domain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001240684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240684", "type": "external" } ], "gene_names_uniprotkb": "Tdrd3", "gene_names_refseq": "4732418C03Rik; 6720468N18; Tdrd3", "protein_names_uniprotkb": "Tudor domain-containing protein 3", "protein_names_refseq": "tudor domain-containing protein 3 isoform 2; tudor domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:219249)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21183079;21750661;25428506;30084848;38216113", "class_list": "", "function": "Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2Q4;Q6NZG7;Q8BZW6;Q8C1A4", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0140008 histone H4 reader activity;GO:0140006 histone H3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0006265 DNA topological change;GO:0141194 siRNA-mediated heterochromatin formation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91W18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YJ3-1", "uniprot_id": [ { "id": "THYN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YJ3", "type": "external" } ], "mass": 26178.0, "length": 226, "protein_name": "Thymocyte nuclear protein 1", "gene_name": "Thyn1", "organism": "Mouse", "refseq_name": "thymocyte nuclear protein 1 isoform 1", "refseq_ac": [ { "id": "NP_653126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653126", "type": "external" } ], "gene_names_uniprotkb": "Thyn1; Thy28", "gene_names_refseq": "D730042P09Rik; HSPC144; MDS012; MY105; Thy28; Thyn1", "protein_names_uniprotkb": "Thymocyte nuclear protein 1; Thymocyte protein Thy28; mThy28", "protein_names_refseq": "mThy28; thymocyte nuclear protein 1 isoform 1; thymocyte protein thy28", "tax_id": 10090, "disease": "", "pathway": " (mmu:77862)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12384300;14580360;14601557;22139584;23434322;25428506;25547913;30084848;31219806;31329649;31599954", "class_list": "", "function": "Down-regulation of the nuclear Thy28 expression appears to correlate with the induction of apoptosis in Ramos B lymphoma cells, [RefSeq, PubMed]; Modulation of Thy28 expression plays a crucial role in the determination of thymic cell fate., [RefSeq, PubMed]; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, PubMed]; Thy28 regulates mIg-mediated apoptotic events through the JNK-H(2)O(2) activation pathway, concomitant with an accumulation of cells in G1 phase associated with upregulation of p27(Kip1), [RefSeq, PubMed]; Thy28-deficient mice showed normal development of B cells and unaltered Pax5 expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q91YJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923W1-1", "uniprot_id": [ { "id": "TGS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q923W1", "type": "external" } ], "mass": 96790.0, "length": 853, "protein_name": "Trimethylguanosine synthase", "gene_name": "Tgs1", "organism": "Mouse", "refseq_name": "trimethylguanosine synthase", "refseq_ac": [ { "id": "NP_473430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473430", "type": "external" } ], "gene_names_uniprotkb": "Tgs1; Ncoa6ip; Pimt", "gene_names_refseq": "D4Ertd800e; Ncoa6ip; Pimt; Tgs1", "protein_names_uniprotkb": "Trimethylguanosine synthase; 2.1.1.-; Cap-specific guanine-N(2) methyltransferase; Nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP-interacting protein with methyltransferase motif", "protein_names_refseq": "PIPMT; PRIP-interacting protein with methyltransferase motif; cap-specific guanine-N(2) methyltransferase; nuclear receptor coactivator 6-interacting protein; trimethylguanosine synthase homolog; trimethylguanosine synthase", "tax_id": 10090, "disease": "", "pathway": " (mmu:116940); (R-MMU-191859); (R-MMU-400206); (R-MMU-9707564)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11517327;20485683;21183079;26495903;31219806;35041827;37175791;37673359;37751782", "class_list": "", "function": "Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity)., [UniProtKB, PubMed, UniProtKB]; PIMT Controls Insulin Synthesis and Secretion through PDX1. Publication Status: Online-Only, [RefSeq, PubMed]; TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice., [RefSeq, PubMed]; TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells., [RefSeq, PubMed]; Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AJF7;Q6DI60;Q6PEA7;Q8R0W9", "ec_number_list": [ { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" } ], "go_molecular_function": "GO:0071164 RNA cap trimethylguanosine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015030 Cajal body", "go_biological_process": "GO:0036261 7-methylguanosine cap hypermethylation;GO:0006351 DNA-templated transcription;GO:0042308 negative regulation of protein import into nucleus;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q923W1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99KW9-1", "uniprot_id": [ { "id": "TIP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99KW9", "type": "external" } ], "mass": 67465.0, "length": 610, "protein_name": "T-cell immunomodulatory protein", "gene_name": "Itfg1", "organism": "Mouse", "refseq_name": "T-cell immunomodulatory protein precursor", "refseq_ac": [ { "id": "NP_082283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082283", "type": "external" } ], "gene_names_uniprotkb": "Itfg1; D8Wsu49e; Lnkn-1; Tip", "gene_names_refseq": "2310047C21Rik; Cda08; D8Wsu49e; Itfg1", "protein_names_uniprotkb": "T-cell immunomodulatory protein; Integrin-alpha FG-GAP repeat-containing protein 1; Linkin; Protein TIP", "protein_names_refseq": "T-cell immunomodulatory protein precursor; T-cell immunomodulatory protein; integrin-alpha FG-GAP repeat-containing protein 1; linkin", "tax_id": 10090, "disease": "", "pathway": " (mmu:71927)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;12598909;16075062;26495903;26740625;30899004;32152506;33300544", "class_list": "", "function": "Modulator of T-cell function. Has a protective effect in graft versus host disease model., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 6, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ11;Q9D6X1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q99KW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MB3-1", "uniprot_id": [ { "id": "TM2D1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MB3", "type": "external" } ], "mass": 22272.0, "length": 208, "protein_name": "TM2 domain-containing protein 1", "gene_name": "Tm2d1", "organism": "Mouse", "refseq_name": "TM2 domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_444387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444387", "type": "external" } ], "gene_names_uniprotkb": "Tm2d1; Bbp", "gene_names_refseq": "2310026L18Rik; Bbp; Tm2d1", "protein_names_uniprotkb": "TM2 domain-containing protein 1; Amyloid-beta-binding protein; mBBP", "protein_names_refseq": "TM2 domain-containing protein 1 precursor; TM2 domain-containing protein 1; amyloid-beta-binding protein; beta-amyloid binding protein; mBBP", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:94043)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;11278849;21750661;40021952", "class_list": "", "function": "May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2ADR1;A2ADR4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097190 apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99MB3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PM3-1", "uniprot_id": [ { "id": "TF2AA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PM3", "type": "external" } ], "mass": 41614.0, "length": 378, "protein_name": "Transcription initiation factor IIA subunit 1", "gene_name": "Gtf2a1", "organism": "Mouse", "refseq_name": "transcription initiation factor IIA subunit 1 isoform 1", "refseq_ac": [ { "id": "NP_113568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113568", "type": "external" } ], "gene_names_uniprotkb": "Gtf2a1", "gene_names_refseq": "6330549H03Rik; Gtf2a1; TfIIAa/b; Tfiia1", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 1; General transcription factor IIA subunit 1; TFIIA p19 subunit; TFIIA p35 subunit", "protein_names_refseq": "TFIIA alpha/beta; general transcription factor IIA subunit 1; general transcription factor IIa, 1 (37kD and 19kD subunits); transcription initiation factor IIA subunit 1 isoform 1; transcription initiation factor IIA subunit 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83602); (R-MMU-674695); (R-MMU-6807505); (R-MMU-73776); (R-MMU-73779); (R-MMU-75953); (R-MMU-76042); (R-MMU-9018519)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "11159353;25664857", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)., [UniProtKB]; TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C812", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025 TBP-class protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR81-1", "uniprot_id": [ { "id": "TEX12_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR81", "type": "external" } ], "mass": 13958.0, "length": 123, "protein_name": "Testis-expressed protein 12", "gene_name": "Tex12", "organism": "Mouse", "refseq_name": "testis-expressed protein 12", "refseq_ac": [ { "id": "NP_079963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079963", "type": "external" } ], "gene_names_uniprotkb": "Tex12", "gene_names_refseq": "5730518K06Rik; Tex12", "protein_names_uniprotkb": "Testis-expressed protein 12", "protein_names_refseq": "testis expressed gene 12; testis exprtessed gene 12; testis-expressed protein 12; testis-expressed sequence 12 protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:66654)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11279525;16968740;18611960;30949703", "class_list": "", "function": "Component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:16968740). Requires SYCP1 in order to be incorporated into the central element (PubMed:16968740)., [UniProtKB, PubMed]; TEX12 is a component of the central element structure of the synaptonemal complex required for propagation of synapsis along the paired homologous chromosomes and maturation of early recombination events into crossovers, [RefSeq, PubMed]; TEX12 specifically co-precipitated with SYCE2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000801 central element;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0036064 ciliary basal body;GO:0005694 chromosome", "go_biological_process": "GO:0007130 synaptonemal complex assembly;GO:0000711 meiotic DNA repair synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CU24-1", "uniprot_id": [ { "id": "THMS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CU24", "type": "external" } ], "mass": 64720.0, "length": 569, "protein_name": "Protein THEMIS3", "gene_name": "Themis3", "organism": "Mouse", "refseq_name": "protein THEMIS3", "refseq_ac": [ { "id": "NP_083274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083274", "type": "external" } ], "gene_names_uniprotkb": "Themis3", "gene_names_refseq": "9130404H23Rik; Themis3", "protein_names_uniprotkb": "Protein THEMIS3; Thymocyte-expressed molecule involved in selection protein 3", "protein_names_refseq": "protein THEMIS3; thymocyte-expressed molecule involved in selection protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:74556)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19597497;19597499", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CU24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CY52-1", "uniprot_id": [ { "id": "THG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CY52", "type": "external" } ], "mass": 34971.0, "length": 298, "protein_name": "Probable tRNA(His) guanylyltransferase", "gene_name": "Thg1l", "organism": "Mouse", "refseq_name": "probable tRNA(His) guanylyltransferase isoform 1", "refseq_ac": [ { "id": "NP_001074438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074438", "type": "external" } ], "gene_names_uniprotkb": "Thg1l", "gene_names_refseq": "Thg1l", "protein_names_uniprotkb": "Probable tRNA(His) guanylyltransferase; 2.7.7.79; tRNA-histidine guanylyltransferase", "protein_names_refseq": "interphase cyctoplasmic foci protein 45; probable tRNA(His) guanylyltransferase isoform 1; probable tRNA(His) guanylyltransferase", "tax_id": 10090, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); autosomal recessive spinocerebellar ataxia 28 (Disease Ontology:DOID:0070409); cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:66628)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q562D7", "ec_number_list": [ { "id": "2.7.7.79", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.79", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:1990046 stress-induced mitochondrial fusion;GO:0006979 response to oxidative stress;GO:0008033 tRNA processing;GO:0051289 protein homotetramerization;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9CY52-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D328-1", "uniprot_id": [ { "id": "NACHO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D328", "type": "external" } ], "mass": 18505.0, "length": 167, "protein_name": "Novel acetylcholine receptor chaperone", "gene_name": "Tmem35a", "organism": "Mouse", "refseq_name": "nicotinic acetylcholine receptor chaperone", "refseq_ac": [ { "id": "NP_080515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080515", "type": "external" } ], "gene_names_uniprotkb": "Tmem35a; Nacho; Tmem35", "gene_names_refseq": "9030603L14Rik; NACHO; PMP52; Tmem35a; Tmem35", "protein_names_uniprotkb": "Novel acetylcholine receptor chaperone; PMP52; Peroxisomal membrane protein 52; Transmembrane protein 35A", "protein_names_refseq": "nicotinic acetylcholine receptor chaperone; novel acetylcholine receptor chaperone; peroxisomal membrane protein 52; transmembrane protein 35", "tax_id": 10090, "disease": "", "pathway": " (mmu:67564)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17768142;26875622;27170659;28445721;32204458;32783947;33422618", "class_list": "", "function": "Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:28445721, PubMed:32204458). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:28445721, PubMed:32204458). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (PubMed:32783947). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly., [RefSeq, PubMed]; Pathway analysis of differentially expressed synaptic proteins in tmem35 KO hippocampus implicated molecular networks associated with specific cellular and behavioral functions, including decreased long-term potentiation, and increased startle reactivity, [RefSeq, PubMed]; The nAChR Chaperone TMEM35a (NACHO) Contributes to the Development of Hyperalgesia in Mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DB64", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:2000010 positive regulation of protein localization to cell surface;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9D328-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7I9-1", "uniprot_id": [ { "id": "TGM5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7I9", "type": "external" } ], "mass": 81014.0, "length": 724, "protein_name": "Protein-glutamine gamma-glutamyltransferase 5", "gene_name": "Tgm5", "organism": "Mouse", "refseq_name": "protein-glutamine gamma-glutamyltransferase 5 isoform 1", "refseq_ac": [ { "id": "NP_083075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083075", "type": "external" } ], "gene_names_uniprotkb": "Tgm5", "gene_names_refseq": "2310007C07Rik; TGMX; TGase-5; TGx; Tgm5", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 5; 2.3.2.13; TGase-5; Transglutaminase-5", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase 5 isoform 1; protein-glutamine gamma-glutamyltransferase 5", "tax_id": 10090, "disease": "peeling skin syndrome 2 (Disease Ontology:DOID:0070521)", "pathway": " (mmu:74176)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ62;Q3V1F9", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D7I9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D7K2-1", "uniprot_id": [ { "id": "TEN1L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D7K2", "type": "external" } ], "mass": 18066.0, "length": 161, "protein_name": "CST complex subunit TEN1", "gene_name": "Ten1", "organism": "Mouse", "refseq_name": "CST complex subunit TEN1", "refseq_ac": [ { "id": "NP_081383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081383", "type": "external" } ], "gene_names_uniprotkb": "Ten1", "gene_names_refseq": "2310004N24Rik; Ten1", "protein_names_uniprotkb": "CST complex subunit TEN1; Protein telomeric pathways with STN1 homolog; Telomere length regulation protein TEN1 homolog", "protein_names_refseq": "CST complex subunit TEN1; protein telomeric pathways with STN1 homolog; telomere length regulation protein TEN1 homolog", "tax_id": 10090, "disease": "dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (mmu:69535); (R-MMU-174411); (R-MMU-174430)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "19854130;31219806;34428180", "class_list": "", "function": "Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0003697 single-stranded DNA binding;GO:0010521 telomerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0032211 negative regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D7K2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D850-1", "uniprot_id": [ { "id": "DIESL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D850", "type": "external" } ], "mass": 37810.0, "length": 329, "protein_name": "DGAT1/2-independent enzyme synthesizing storage lipids", "gene_name": "Tmem68", "organism": "Mouse", "refseq_name": "DGAT1/2-independent enzyme synthesizing storage lipids", "refseq_ac": [ { "id": "NP_082373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082373", "type": "external" } ], "gene_names_uniprotkb": "Tmem68", "gene_names_refseq": "2010300G19Rik; Diesl; MGAT/DGAT; Tmem68", "protein_names_uniprotkb": "DGAT1/2-independent enzyme synthesizing storage lipids; 2-acylglycerol/1,2-diacylglycerol O-acyltransferase; 2.3.1.-; 2.3.1.20; 2.3.1.22; DIESL; MGAT/DGAT; Monoacylglycerol/Diacylglycerol O-acyltransferase; Transmembrane protein 68", "protein_names_refseq": "2-acylglycerol/1,2-diacylglycerol O-acyltransferase; DGAT1/2-independent enzyme synthesizing storage lipids; monoacylglycerol/Diacylglycerol O-acyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:72098)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;28472192;36768334;37648867", "class_list": "", "function": "Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (By similarity). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (PubMed:36768334)., [UniProtKB, UniProtKB, PubMed, PubMed]; Identification of an alternative triglyceride biosynthesis pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGT4;Q8BTV3", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" }, { "id": "2.3.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0046027 phospholipid:diacylglycerol acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D850-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA04-1", "uniprot_id": [ { "id": "TMM89_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA04", "type": "external" } ], "mass": 18598.0, "length": 169, "protein_name": "Transmembrane protein 89", "gene_name": "Tmem89", "organism": "Mouse", "refseq_name": "transmembrane protein 89 precursor", "refseq_ac": [ { "id": "NP_081342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081342", "type": "external" } ], "gene_names_uniprotkb": "Tmem89", "gene_names_refseq": "1700024B07Rik; Tmem89", "protein_names_uniprotkb": "Transmembrane protein 89", "protein_names_refseq": "transmembrane protein 89 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69384)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2L9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DA04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA47-1", "uniprot_id": [ { "id": "TM239_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA47", "type": "external" } ], "mass": 17201.0, "length": 151, "protein_name": "Transmembrane protein 239", "gene_name": "Tmem239", "organism": "Mouse", "refseq_name": "transmembrane protein 239", "refseq_ac": [ { "id": "NP_080029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080029", "type": "external" } ], "gene_names_uniprotkb": "Tmem239", "gene_names_refseq": "4933425O20Rik; Tmem239", "protein_names_uniprotkb": "Transmembrane protein 239", "protein_names_refseq": "transmembrane protein 239", "tax_id": 10090, "disease": "", "pathway": " (mmu:66766)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9DA47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DA60-1", "uniprot_id": [ { "id": "TEX44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DA60", "type": "external" } ], "mass": 56574.0, "length": 530, "protein_name": "Testis-expressed protein 44", "gene_name": "Tex44", "organism": "Mouse", "refseq_name": "testis-expressed protein 44", "refseq_ac": [ { "id": "NP_082242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082242", "type": "external" } ], "gene_names_uniprotkb": "Tex44", "gene_names_refseq": "1700019O17Rik; Tex44", "protein_names_uniprotkb": "Testis-expressed protein 44", "protein_names_refseq": "testis-expressed protein 44; uncharacterized protein C2orf57 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:71863)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38750428", "class_list": "", "function": "The lack of Tex44 causes severe subfertility with flagellar abnormalities in male mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H651;Q497K4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DA60-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET30-1", "uniprot_id": [ { "id": "TM9S3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ET30", "type": "external" } ], "mass": 67545.0, "length": 587, "protein_name": "Transmembrane 9 superfamily member 3", "gene_name": "Tm9sf3", "organism": "Mouse", "refseq_name": "transmembrane 9 superfamily member 3 precursor", "refseq_ac": [ { "id": "NP_579930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579930", "type": "external" } ], "gene_names_uniprotkb": "Tm9sf3; Smbp", "gene_names_refseq": "1810073M23Rik; 2810031D16Rik; Smbp; Tm9sf3; mKIAA4036", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 3", "protein_names_refseq": "SM-11044 binding protein; transmembrane 9 superfamily member 3 precursor; transmembrane protein 9 superfamily member 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:107358)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19349973;19656770;21750661;28011936;34428180;37828378", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ET30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKK7-1", "uniprot_id": [ { "id": "TMOD2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKK7", "type": "external" } ], "mass": 39511.0, "length": 351, "protein_name": "Tropomodulin-2", "gene_name": "Tmod2", "organism": "Mouse", "refseq_name": "tropomodulin-2", "refseq_ac": [ { "id": "NP_001033799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033799", "type": "external" } ], "gene_names_uniprotkb": "Tmod2", "gene_names_refseq": "N-Tmod; NTMOD; Tmod2", "protein_names_uniprotkb": "Tropomodulin-2; N-Tmod; Neuronal tropomodulin", "protein_names_refseq": "neural tropomodulin; neuronal tropomodulin; tropomodulin-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:50876); (R-MMU-390522)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10662549;12799133;21750661;32848054", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB]; Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UH50;Q8BGX9;Q9CUK4;Q9JLH9", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030426 growth cone;GO:0045202 synapse;GO:0005865 striated muscle thin filament;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0007611 learning or memory;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007270 neuron-neuron synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLF7-1", "uniprot_id": [ { "id": "TLR5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLF7", "type": "external" } ], "mass": 97627.0, "length": 859, "protein_name": "Toll-like receptor 5", "gene_name": "Tlr5", "organism": "Mouse", "refseq_name": "toll-like receptor 5 precursor", "refseq_ac": [ { "id": "NP_058624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058624", "type": "external" } ], "gene_names_uniprotkb": "Tlr5", "gene_names_refseq": "Tlr5", "protein_names_uniprotkb": "Toll-like receptor 5", "protein_names_refseq": "toll-like receptor 5 precursor", "tax_id": 10090, "disease": "Legionnaires' disease (Disease Ontology:DOID:10457); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); chronic granulomatous disease (Disease Ontology:DOID:3265); melioidosis (Disease Ontology:DOID:5052); ankylosing spondylitis (Disease Ontology:DOID:7147); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (mmu:53791)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10756091;12794153;15302888;21750661;25428506;30084848;30089902;30779550;34428180;35820727", "class_list": "", "function": "Gram-negative flagellin stimulates nitric oxide production in macrophages via a pathway that requires TLR5 in complex with TLR4., [RefSeq, PubMed]; Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; TLR5 is activated in intestinal epithelial cells by a commensal Escherichia coli strain, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005149 interleukin-1 receptor binding;GO:0038187 pattern recognition receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0032757 positive regulation of interleukin-8 production;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JLF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLL3-1", "uniprot_id": [ { "id": "TNR19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLL3", "type": "external" } ], "mass": 45265.0, "length": 416, "protein_name": "Tumor necrosis factor receptor superfamily member 19", "gene_name": "Tnfrsf19", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 19 precursor", "refseq_ac": [ { "id": "NP_001157627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157627", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf19; Taj; Troy", "gene_names_refseq": "TAJ-ALPHA; TAJ; TRADE; Tnfrsf19; Troy", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 19; TRADE; Toxicity and JNK inducer", "protein_names_refseq": "Toxicity and JNK inducer; tumor necrosis factor receptor superfamily member 19 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:29820)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;10585776;10764796;10809768", "class_list": "", "function": "Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80T13;Q812G3;Q9JHF1;Q9JJH6;Q9JLL2;Q9QXW7", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JLL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTS6-1", "uniprot_id": [ { "id": "TEN3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTS6", "type": "external" } ], "mass": 303066.0, "length": 2715, "protein_name": "Teneurin-3", "gene_name": "Tenm3", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tenm3; Kiaa1455; Odz3; Tnm3", "gene_names_refseq": "", "protein_names_uniprotkb": "Teneurin-3; Protein Odd Oz/ten-m homolog 3; Ten-3; Ten-m3; Tenascin-M3; Teneurin transmembrane protein 3", "protein_names_refseq": "", "tax_id": 10090, "disease": "cocaine dependence (Disease Ontology:DOID:9975)", "pathway": "", "pathway_count": 0, "publication_count": 18, "publication_id_list": "10.1101/2023.09.13.557529;10225957;10625539;12000766;12915301;17478416;17803360;18322192;19656770;20636325;21750661;22499796;23028443;25406022;29414938;30899004;34678516;40885482", "class_list": "", "function": "Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:17478416, PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022, PubMed:29414938). Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (PubMed:29414938). Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction (PubMed:29414938). Promotes axon guidance (PubMed:23028443). Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway (PubMed:17803360, PubMed:22499796, PubMed:23028443, PubMed:25406022). Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC) (PubMed:17803360, PubMed:23028443). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes (PubMed:20636325)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 14, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 10, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 15, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 15, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A0A2K9QKY6;A0A2K9QKZ0;A0A2K9QL01;A0A2K9QL03;A0A2K9QL04;A0A2K9QL11;A0A2K9QL36;A0A2K9QL87;Q3UVR9;Q3UX72;Q80TD2;Q8BSL5;Q9CSV2;Q9JLC1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048666 neuron development;GO:0048593 camera-type eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q9WTS6-1", "record_type": "protein", "filter_code": "0000000.1000110.001000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86449-1", "uniprot_id": [ { "id": "TR43C_MOUSE", "url": "https://www.uniprot.org/uniprot/P86449", "type": "external" } ], "mass": 52533.0, "length": 446, "protein_name": "Tripartite motif-containing protein 43C", "gene_name": "Trim43c", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 43C", "refseq_ac": [ { "id": "NP_001171329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171329", "type": "external" } ], "gene_names_uniprotkb": "Trim43c", "gene_names_refseq": "EG666731; Trim43c; Trim43", "protein_names_uniprotkb": "Tripartite motif-containing protein 43C", "protein_names_refseq": "tripartite motif-containing 43; tripartite motif-containing protein 43C", "tax_id": 10090, "disease": "", "pathway": " (mmu:666731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19703589;21750661", "class_list": "", "function": "We describe the identification and characterization of Trim43a, Trim43b, and Trim43c genes, whose expression are restricted to preimplantation stages and peak at the 8-cell to morula stage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86449-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70472-1", "uniprot_id": [ { "id": "TM131_MOUSE", "url": "https://www.uniprot.org/uniprot/O70472", "type": "external" } ], "mass": 204651.0, "length": 1877, "protein_name": "Transmembrane protein 131", "gene_name": "Tmem131", "organism": "Mouse", "refseq_name": "transmembrane protein 131 precursor", "refseq_ac": [ { "id": "NP_061360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061360", "type": "external" } ], "gene_names_uniprotkb": "Tmem131; D1Bwg0491e; Kiaa0257; Rw1", "gene_names_refseq": "2610524E03Rik; CC28; D1Bwg0491e; Neg; RW1; Tmem131; YR-23; mKIAA0257", "protein_names_uniprotkb": "Transmembrane protein 131; Protein RW1", "protein_names_refseq": "transmembrane protein 131 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:56030)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;10996388;21750661;25428506;30084848;30899004;31219806;31599954;34428180;36210013;37828378", "class_list": "", "function": "Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (By similarity). May play a role in the immune response to viral infection., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHH3", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0032964 collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "O70472-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZQF0-1", "uniprot_id": [ { "id": "TOPB1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZQF0", "type": "external" } ], "mass": 168860.0, "length": 1515, "protein_name": "DNA topoisomerase 2-binding protein 1", "gene_name": "Topbp1", "organism": "Mouse", "refseq_name": "DNA topoisomerase 2-binding protein 1", "refseq_ac": [ { "id": "NP_795953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795953", "type": "external" } ], "gene_names_uniprotkb": "Topbp1; Kiaa0259", "gene_names_refseq": "1110031N14Rik; 2810429C13Rik; D430026L04Rik; Topbp1; mKIAA0259", "protein_names_uniprotkb": "DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; TopBP1", "protein_names_refseq": "DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; topoisomerase (DNA) II beta binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:235559); (R-MMU-5685938); (R-MMU-5693607); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "14718568;15138768;21183079;21750661;22549958;25428506;25605945;31219806;34428180;36999590;38391183", "class_list": "", "function": "A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation. Publication Status: Online-Only, [RefSeq, PubMed]; ATR and TopBP1 monitor meiotic recombination and are required for activation of the meiotic recombination checkpoint, [RefSeq, PubMed]; Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes., [RefSeq, PubMed]; Scaffold protein that acts as a key protein-protein adapter in DNA replication and DNA repair. Composed of multiple BRCT domains, which specifically recognize and bind phosphorylated proteins, bringing proteins together into functional combinations (PubMed:14718568). Required for DNA replication initiation but not for the formation of pre-replicative complexes or the elongation stages (By similarity). Necessary for the loading of replication factors onto chromatin, including GMNC, CDC45, DNA polymerases and components of the GINS complex (By similarity). Plays a central role in DNA repair by bridging proteins and promoting recruitment of proteins to DNA damage sites (By similarity). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the exchange between the DNA replication factor A (RPA) complex and RAD51 (By similarity). Mechanistically, TOPBP1 is recruited to DNA damage sites in S-phase via interaction with phosphorylated HTATSF1, and promotes the loading of RAD51, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (By similarity). Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis (By similarity). MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair DSBs in DNA that originate in S-phase (By similarity). Recognizes and binds POLQ phosphorylated by PLK1, enabling its recruitment to DSBs for subsequent repair (By similarity). Involved in G1 DNA damage checkpoint by acting as a molecular adapter that couples TP53BP1 and the 9-1-1 complex (By similarity). In response to DNA damage, triggers the recruitment of checkpoint signaling proteins on chromatin, which activate the CHEK1 signaling pathway and block S-phase progression (By similarity). Acts as an activator of the kinase activity of ATR (By similarity). Also required for chromosomal stability when DSBs occur during mitosis by forming filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis (By similarity). Together with CIP2A, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters, thereby down-regulating E2F1 activity and inhibiting E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6P0;Q80Y33;Q8BUI0;Q8BUK1;Q8R348;Q91VX3;Q922X8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140031 phosphorylation-dependent protein binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0000076 DNA replication checkpoint signaling;GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6ZQF0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z1U7-1", "uniprot_id": [ { "id": "TM233_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z1U7", "type": "external" } ], "mass": 11997.0, "length": 110, "protein_name": "Transmembrane protein 233", "gene_name": "Tmem233", "organism": "Mouse", "refseq_name": "transmembrane protein 233", "refseq_ac": [ { "id": "NP_001095016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095016", "type": "external" } ], "gene_names_uniprotkb": "Tmem233", "gene_names_refseq": "DSPB2; Gm13843; Mcare; Tmem233", "protein_names_uniprotkb": "Transmembrane protein 233; DSPB2; Dispanin subfamily B member 2", "protein_names_refseq": "dispanin subfamily B member 2; transmembrane protein 233", "tax_id": 10090, "disease": "", "pathway": " (mmu:545798)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;22363774;34418053;37117223", "class_list": "", "function": "Probable accessory protein of voltage-gated sodium channels., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3Z1U7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K003-1", "uniprot_id": [ { "id": "TMA7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K003", "type": "external" } ], "mass": 7066.0, "length": 64, "protein_name": "Translation machinery-associated protein 7", "gene_name": "Tma7", "organism": "Mouse", "refseq_name": "translation machinery-associated protein 7", "refseq_ac": [ { "id": "NP_899073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899073", "type": "external" } ], "gene_names_uniprotkb": "Tma7; Ccdc72", "gene_names_refseq": "1110017O22Rik; Ccdc72; Tma7", "protein_names_uniprotkb": "Translation machinery-associated protein 7; Coiled-coil domain-containing protein 72", "protein_names_refseq": "coiled-coil domain containing 72; coiled-coil domain-containing protein 72; translation machinery-associated protein 7; translational machinery associated 7 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66167)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K003-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BH58-1", "uniprot_id": [ { "id": "TIPRL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BH58", "type": "external" } ], "mass": 31254.0, "length": 271, "protein_name": "TIP41-like protein", "gene_name": "Tiprl", "organism": "Mouse", "refseq_name": "TIP41-like protein isoform 1", "refseq_ac": [ { "id": "NP_663488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663488", "type": "external" } ], "gene_names_uniprotkb": "Tiprl", "gene_names_refseq": "1810011K17Rik; Tiprl", "protein_names_uniprotkb": "TIP41-like protein", "protein_names_refseq": "TIP41-like protein isoform 1; TIP41-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:226591)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "21750661;22872234;25428506;26717153;28528544;29273778;31219806;33725478;34203471;34428180;36210013", "class_list": "", "function": "May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity)., [UniProtKB, UniProtKB]; Overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation Publication Status: Online-Only, [RefSeq, PubMed]; TIPRL (TOR signaling pathway regulator) makes highly integrative multibranching contacts with the PP2A catalytic subunit, selective for the unmethylated tail and perturbing/inactivating the phosphatase active site. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0031929 TOR signaling;GO:0000077 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8BH58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X8R9-1", "uniprot_id": [ { "id": "TMIG3_MOUSE", "url": "https://www.uniprot.org/uniprot/G3X8R9", "type": "external" } ], "mass": 23452.0, "length": 209, "protein_name": "Transmembrane domain-containing protein TMIGD3", "gene_name": "Tmigd3", "organism": "Mouse", "refseq_name": "transmembrane domain-containing protein TMIGD3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_081301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081301", "type": "external" } ], "gene_names_uniprotkb": "Tmigd3", "gene_names_refseq": "1700001d09rik; 4930578J19Rik; Tg(H2-K-CALR*)del52Shmd; Tmigd3", "protein_names_uniprotkb": "Transmembrane domain-containing protein TMIGD3", "protein_names_refseq": "transmembrane domain-containing protein TMIGD3 isoform 2 precursor; transmembrane domain-containing protein TMIGD3", "tax_id": 10090, "disease": "", "pathway": " (mmu:69296)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 3' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:11542). [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DAR9", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0002757 immune response-activating signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3X8R9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q3-1", "uniprot_id": [ { "id": "TMED2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R0Q3", "type": "external" } ], "mass": 22705.0, "length": 201, "protein_name": "Transmembrane emp24 domain-containing protein 2", "gene_name": "Tmed2", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_062744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062744", "type": "external" } ], "gene_names_uniprotkb": "Tmed2; Rnp24; Sid394", "gene_names_refseq": "1110032D12Rik; 1810020N21Rik; Rnp24; Sid394; Tmed2; p24beta1", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 2; COPI-coated vesicle membrane protein p24; Membrane protein p24A; Sid 394; p24 family protein beta-1; p24beta1", "protein_names_refseq": "COPI-coated vesicle membrane protein p24; Sid394p; coated vesicle membrane protein; membrane protein p24A; p24 family protein beta-1; sid 394; transmembrane emp24 domain trafficking protein 2; transmembrane emp24 domain-containing protein 2 isoform 2 precursor; transmembrane emp24 domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:56334); (R-MMU-1912420); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "20178780;20712584;21750661;28797121;34428180;35353806;38354922", "class_list": "", "function": "Histological and molecular analysis of livers from heterozygous mice carrying the 99J mutation, Tmed299J/+, revealed a requirement for TMED2 in liver health. The study shows that Tmed299J/+ mice had decreased levels of TMED2 and TMED10, dilated endoplasmic reticulum membrane, and increased phosphorylation of eIF2alpha, indicating endoplasmic reticulum - stress. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing (By similarity). Required for morphogenesis of embryo and placenta., [UniProtKB, PubMed]; Study finds that Tmed2/p24beta(1) is normally expressed in tissues showing morphological defects in 99J mutant embryos and that these affected tissues lack the TMED2/p24beta(1) oligomerization partners, TMED7/p24gamma(3) and TMED10/p24delta(1)., [RefSeq, PubMed]; TMED2 binding restricts SMO to the ER and Golgi compartments. Publication Status: Online-Only, [RefSeq, PubMed]; TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport., [RefSeq, PubMed]; Tmed2, which has never been reported yet in cell proliferation, was verified to be able to enhance MC3T3-E1 cell proliferation when over-expressed, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0060717 chorion development;GO:0090158 endoplasmic reticulum membrane organization;GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R0Q3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGY5-1", "uniprot_id": [ { "id": "TM140_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGY5", "type": "external" } ], "mass": 20767.0, "length": 185, "protein_name": "Transmembrane protein 140", "gene_name": "Tmem140", "organism": "Mouse", "refseq_name": "transmembrane protein 140", "refseq_ac": [ { "id": "NP_932103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932103", "type": "external" } ], "gene_names_uniprotkb": "Tmem140", "gene_names_refseq": "1110007F12Rik; Tmem140", "protein_names_uniprotkb": "Transmembrane protein 140", "protein_names_refseq": "transmembrane protein 140", "tax_id": 10090, "disease": "", "pathway": " (mmu:68487)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDY2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06804-1", "uniprot_id": [ { "id": "TNFA_MOUSE", "url": "https://www.uniprot.org/uniprot/P06804", "type": "external" } ], "mass": 25896.0, "length": 235, "protein_name": "Tumor necrosis factor", "gene_name": "Tnf", "organism": "Mouse", "refseq_name": "tumor necrosis factor isoform 2", "refseq_ac": [ { "id": "NP_001265530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265530", "type": "external" } ], "gene_names_uniprotkb": "Tnf; Tnfa; Tnfsf2", "gene_names_refseq": "DIF; TNF-alpha; TNF-a; TNFSF2; TNFalpha; Tnfa; Tnfsf1a; Tnf; Tnlg1f", "protein_names_uniprotkb": "Tumor necrosis factor; Cachectin; N-terminal fragment; NTF; TNF-alpha; TNF-a; Tumor necrosis factor ligand superfamily member 2", "protein_names_refseq": "cachectin; tumor necrosis factor isoform 2; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha", "tax_id": 10090, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); mevalonic aciduria (Disease Ontology:DOID:0050452); Weill-Marchesani syndrome (Disease Ontology:DOID:0050475); inflammatory bowel disease (Disease Ontology:DOID:0050589); hypochromic microcytic anemia (Disease Ontology:DOID:0050642); small cell carcinoma (Disease Ontology:DOID:0050685); chorioamnionitis (Disease Ontology:DOID:0050697); cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); cardiac arrest (Disease Ontology:DOID:0060319); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); immunodeficiency 127 (Disease Ontology:DOID:0061092); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); erythema nodosum (Disease Ontology:DOID:0080750); Graves ophthalmopathy (Disease Ontology:DOID:0081120); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); sensorineural hearing loss (Disease Ontology:DOID:10003); leprosy (Disease Ontology:DOID:1024); thalassemia (Disease Ontology:DOID:10241); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); silicosis (Disease Ontology:DOID:10325); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); anogenital venereal wart (Disease Ontology:DOID:11168); spondyloarthropathy (Disease Ontology:DOID:1123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); cicatricial pemphigoid (Disease Ontology:DOID:11656); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); hepatorenal syndrome (Disease Ontology:DOID:11823); esophagitis (Disease Ontology:DOID:11963); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); neutropenia (Disease Ontology:DOID:1227); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); hepatitis A (Disease Ontology:DOID:12549); paracoccidioidomycosis (Disease Ontology:DOID:12662); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); intermediate uveitis (Disease Ontology:DOID:12732); migraine without aura (Disease Ontology:DOID:12783); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); autistic disorder (Disease Ontology:DOID:12849); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); dilated cardiomyopathy (Disease Ontology:DOID:12930); periventricular leukomalacia (Disease Ontology:DOID:13088); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); scleritis (Disease Ontology:DOID:13452); low tension glaucoma (Disease Ontology:DOID:13544); Fanconi anemia (Disease Ontology:DOID:13636); peptic esophagitis (Disease Ontology:DOID:13976); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); farmer's lung (Disease Ontology:DOID:14453); root resorption (Disease Ontology:DOID:14550); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); aortic valve stenosis (Disease Ontology:DOID:1712); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); Gaucher's disease (Disease Ontology:DOID:1926); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); transient cerebral ischemia (Disease Ontology:DOID:224); hidradenitis suppurativa (Disease Ontology:DOID:2280); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); dermatitis (Disease Ontology:DOID:2723); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); cryoglobulinemia (Disease Ontology:DOID:2917); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); breast adenocarcinoma (Disease Ontology:DOID:3458); mixed connective tissue disease (Disease Ontology:DOID:3492); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); skin disease (Disease Ontology:DOID:37); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); gastritis (Disease Ontology:DOID:4029); heart valve disease (Disease Ontology:DOID:4079); liver disease (Disease Ontology:DOID:409); coronary restenosis (Disease Ontology:DOID:4247); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); pustulosis of palm and sole (Disease Ontology:DOID:4398); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); endophthalmitis (Disease Ontology:DOID:4692); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); schizophrenia (Disease Ontology:DOID:5419); cochlear disease (Disease Ontology:DOID:5463); kidney disease (Disease Ontology:DOID:557); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); lymphopenia (Disease Ontology:DOID:614); myositis (Disease Ontology:DOID:633); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); acne (Disease Ontology:DOID:6543); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); peritonitis (Disease Ontology:DOID:8283); extrinsic allergic alveolitis (Disease Ontology:DOID:841); corneal ulcer (Disease Ontology:DOID:8463); lung disease (Disease Ontology:DOID:850); dermatitis herpetiformis (Disease Ontology:DOID:8505); Cor pulmonale (Disease Ontology:DOID:8515); herpes zoster (Disease Ontology:DOID:8536); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); alcoholic gastritis (Disease Ontology:DOID:8680); vascular dementia (Disease Ontology:DOID:8725); bacterial pneumonia (Disease Ontology:DOID:874); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hepatopulmonary syndrome (Disease Ontology:DOID:900); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); amyloidosis (Disease Ontology:DOID:9120); visceral leishmaniasis (Disease Ontology:DOID:9146); mucocutaneous leishmaniasis (Disease Ontology:DOID:9155); type 2 diabetes mellitus (Disease Ontology:DOID:9352); epididymitis (Disease Ontology:DOID:9402); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); muscular dystrophy (Disease Ontology:DOID:9884); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (mmu:21926); (R-MMU-5357786); (R-MMU-5357905); (R-MMU-5357956); (R-MMU-5626978); (R-MMU-5668541); (R-MMU-75893)", "pathway_count": 7, "publication_count": 18, "publication_id_list": "10089307;14656967;20194223;21750661;2268312;2419912;25586176;26740625;2777790;2836146;2989794;3040015;32741026;3349526;3684584;3898078;7560085;9089109", "class_list": "", "function": "Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (PubMed:32741026)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The authors summarize the biological activities exerted by different products generated from cleavage of the human TNF. Review article, [RefSeq, PubMed]; This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 197, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35853;Q62326;Q91VF3", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0000976 transcription cis-regulatory region binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0030316 osteoclast differentiation;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032741 positive regulation of interleukin-18 production", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P06804-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9JSM3-1", "uniprot_id": [ { "id": "TM238_MOUSE", "url": "https://www.uniprot.org/uniprot/A9JSM3", "type": "external" } ], "mass": 18226.0, "length": 176, "protein_name": "Transmembrane protein 238", "gene_name": "Tmem238", "organism": "Mouse", "refseq_name": "transmembrane protein 238", "refseq_ac": [ { "id": "NP_083660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083660", "type": "external" } ], "gene_names_uniprotkb": "Tmem238", "gene_names_refseq": "2210411K11Rik; Tmem238", "protein_names_uniprotkb": "Transmembrane protein 238", "protein_names_refseq": "transmembrane protein 238", "tax_id": 10090, "disease": "", "pathway": " (mmu:664968)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9JSM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W27-1", "uniprot_id": [ { "id": "TIP39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W27", "type": "external" } ], "mass": 11022.0, "length": 100, "protein_name": "Tuberoinfundibular peptide of 39 residues", "gene_name": "Pth2", "organism": "Mouse", "refseq_name": "parathyroid hormone 2 preproprotein", "refseq_ac": [ { "id": "NP_444486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444486", "type": "external" } ], "gene_names_uniprotkb": "Pth2; Tip39; Tipf39", "gene_names_refseq": "Pth2; Tifp39; Tip39", "protein_names_uniprotkb": "Tuberoinfundibular peptide of 39 residues; Parathyroid hormone 2; TIP39", "protein_names_refseq": "parathyroid hormone 2 preproprotein; tuberoinfundibular 39 residue protein; tuberoinfundibular peptide of 39 residues (TIP39) preprohormone", "tax_id": 10090, "disease": "", "pathway": " (mmu:114640); (R-MMU-373080); (R-MMU-418555)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11818570;11861531;12084532;12098667;12559132;21750661;26338326;28454729", "class_list": "", "function": "PTH1 receptor antagonism, [RefSeq, PubMed]; Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits., [UniProtKB, PubMed, PubMed, PubMed]; TIP39-PTH2R system appears to be a previously unrecognized mechanism for regulation of extracellular matrix formation and wound repair., [RefSeq, PubMed]; This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. Mice lacking the encoded protein display increased fear and anxiety after exposure to stressful events, and decreased sensitivity to pain. [provided by RefSeq, Aug 2015]., [RefSeq]; This study demonstrated that TIP39 signaling plays a role in fear incubation and suggest that may serve to ameliorate the long-term negative outcome of traumatic experience via PTH2R-expressing neurons in the Medial Nucleus of the Amygdala., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZA0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q91W27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D938-1", "uniprot_id": [ { "id": "TM160_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D938", "type": "external" } ], "mass": 19587.0, "length": 188, "protein_name": "Transmembrane protein 160", "gene_name": "Tmem160", "organism": "Mouse", "refseq_name": "transmembrane protein 160 isoform 1 precursor", "refseq_ac": [ { "id": "NP_081214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081214", "type": "external" } ], "gene_names_uniprotkb": "Tmem160", "gene_names_refseq": "1810008O21Rik; Tmem160", "protein_names_uniprotkb": "Transmembrane protein 160", "protein_names_refseq": "transmembrane protein 160 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69094)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34428180;34936870;38454413", "class_list": "", "function": "TMEM160 promotes tumor immune evasion and radiotherapy resistance via PD-L1 binding in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKH9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D938-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR22-1", "uniprot_id": [ { "id": "TMM42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR22", "type": "external" } ], "mass": 16636.0, "length": 157, "protein_name": "Transmembrane protein 42", "gene_name": "Tmem42", "organism": "Mouse", "refseq_name": "transmembrane protein 42 isoform 2", "refseq_ac": [ { "id": "NP_001158295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158295", "type": "external" } ], "gene_names_uniprotkb": "Tmem42", "gene_names_refseq": "0610027O18Rik; 4933429E06Rik; D9Ertd662e; Tmem42", "protein_names_uniprotkb": "Transmembrane protein 42", "protein_names_refseq": "transmembrane protein 42 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:66079)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CR22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TL54-1", "uniprot_id": [ { "id": "TR43A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TL54", "type": "external" } ], "mass": 52125.0, "length": 445, "protein_name": "Tripartite motif-containing protein 43A", "gene_name": "Trim43a", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 43A isoform 2", "refseq_ac": [ { "id": "NP_001030078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030078", "type": "external" } ], "gene_names_uniprotkb": "Trim43a", "gene_names_refseq": "EG547109; Gm6021; Trim43a", "protein_names_uniprotkb": "Tripartite motif-containing protein 43A", "protein_names_refseq": "tripartite motif-containing protein 43A isoform 2; tripartite motif-containing protein 43A", "tax_id": 10090, "disease": "", "pathway": " (mmu:547109)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19703589;21750661", "class_list": "", "function": "We identified a 5kb DNA fragment that covers upstream region of Trim43a as a putative promoter, which can drive the expression of mStrawberry fluorescent protein in a manner similar to endogenous Trim43 genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EIY7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3TL54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UP23-1", "uniprot_id": [ { "id": "TMM26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UP23", "type": "external" } ], "mass": 41637.0, "length": 366, "protein_name": "Transmembrane protein 26", "gene_name": "Tmem26", "organism": "Mouse", "refseq_name": "transmembrane protein 26", "refseq_ac": [ { "id": "NP_808462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808462", "type": "external" } ], "gene_names_uniprotkb": "Tmem26", "gene_names_refseq": "3230401A06; Tmem26", "protein_names_uniprotkb": "Transmembrane protein 26", "protein_names_refseq": "transmembrane protein 26", "tax_id": 10090, "disease": "", "pathway": " (mmu:327766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;21980401", "class_list": "", "function": "Ubiquitous inactivation of Tmem26 led to no overt phenotype in the resulting embryos or adult mice, suggesting that TMEM26 function is dispensable for embryonic survival., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q149T3;Q8BN94", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3UP23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV98-1", "uniprot_id": [ { "id": "TIM9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WV98", "type": "external" } ], "mass": 10344.0, "length": 89, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Timm9", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim9", "refseq_ac": [ { "id": "NP_001020024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020024", "type": "external" } ], "gene_names_uniprotkb": "Timm9; Tim9a; Tim9; Timm9a", "gene_names_refseq": "2810011L15Rik; Tim10a; Timm10; Timm9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim9", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim9; translocase of inner mitochondrial membrane 10 homolog; translocase of inner mitochondrial membrane 9 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:30056)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10611480;21750661;31219806", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0032977 membrane insertase activity;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WV98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGN6-1", "uniprot_id": [ { "id": "TMG4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGN6", "type": "external" } ], "mass": 25401.0, "length": 226, "protein_name": "Transmembrane gamma-carboxyglutamic acid protein 4", "gene_name": "Prrg4", "organism": "Mouse", "refseq_name": "transmembrane gamma-carboxyglutamic acid protein 4 precursor", "refseq_ac": [ { "id": "NP_848810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848810", "type": "external" } ], "gene_names_uniprotkb": "Prrg4; Prgp4; Tmg4", "gene_names_refseq": "9930111I18Rik; Prrg4; TMG4", "protein_names_uniprotkb": "Transmembrane gamma-carboxyglutamic acid protein 4; Proline-rich Gla protein 4; Proline-rich gamma-carboxyglutamic acid protein 4", "protein_names_refseq": "proline-rich Gla protein 4; proline-rich gamma-carboxyglutamic acid protein 4; transmembrane gamma-carboxyglutamic acid protein 4 precursor; transmembrane gamma-carboxyglutamic acid protein 4", "tax_id": 10090, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (mmu:228413)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM25", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0050699 WW domain binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BGN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0L0-1", "uniprot_id": [ { "id": "TMX4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0L0", "type": "external" } ], "mass": 37131.0, "length": 335, "protein_name": "Thioredoxin-related transmembrane protein 4", "gene_name": "Tmx4", "organism": "Mouse", "refseq_name": "thioredoxin-related transmembrane protein 4 precursor", "refseq_ac": [ { "id": "NP_083424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083424", "type": "external" } ], "gene_names_uniprotkb": "Tmx4; D2Bwg1356e; Kiaa1162; Txndc13", "gene_names_refseq": "2810417D04Rik; 4930500L08Rik; D2Bwg1356e; Tmx4; Txndc13; mKIAA1162", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 4; Thioredoxin domain-containing protein 13", "protein_names_refseq": "thioredoxin domain containing 13; thioredoxin domain-containing protein 13; thioredoxin-related transmembrane protein 4 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:52837)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31142202", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UHC6;Q6ZPW7;Q80X49", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8C0L0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2ARJ3-1", "uniprot_id": [ { "id": "TM236_MOUSE", "url": "https://www.uniprot.org/uniprot/A2ARJ3", "type": "external" } ], "mass": 38680.0, "length": 344, "protein_name": "Transmembrane protein 236", "gene_name": "Tmem236", "organism": "Mouse", "refseq_name": "transmembrane protein 236", "refseq_ac": [ { "id": "NP_001074779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074779", "type": "external" } ], "gene_names_uniprotkb": "Tmem236; Fam23a", "gene_names_refseq": "2010003H20Rik; Fam23a; Gm613; Tmem236", "protein_names_uniprotkb": "Transmembrane protein 236", "protein_names_refseq": "family with sequence similarity 23, member A; transmembrane protein 236", "tax_id": 10090, "disease": "", "pathway": " (mmu:625286)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30084848", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2ARJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810L4-1", "uniprot_id": [ { "id": "TM39B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q810L4", "type": "external" } ], "mass": 56377.0, "length": 492, "protein_name": "Transmembrane protein 39B", "gene_name": "Tmem39b", "organism": "Mouse", "refseq_name": "transmembrane protein 39B isoform 1", "refseq_ac": [ { "id": "NP_955009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955009", "type": "external" } ], "gene_names_uniprotkb": "Tmem39b", "gene_names_refseq": "6330509E05Rik; Tmem39b", "protein_names_uniprotkb": "Transmembrane protein 39B", "protein_names_refseq": "transmembrane protein 39B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:230770)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;21952136;25605945;31219806;34428180;35820727", "class_list": "", "function": "May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q810L4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ85-1", "uniprot_id": [ { "id": "TIM22_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ85", "type": "external" } ], "mass": 20114.0, "length": 194, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Timm22", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim22 isoform 3", "refseq_ac": [ { "id": "NP_001278090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278090", "type": "external" } ], "gene_names_uniprotkb": "Timm22; Tim22", "gene_names_refseq": "Tim22; Timm22", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim22", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim22 isoform 3; mitochondrial import inner membrane translocase subunit Tim22; preprotein translocase; translocase of inner mitochondrial membrane 22 homolog", "tax_id": 10090, "disease": "combined oxidative phosphorylation deficiency 43 (Disease Ontology:DOID:0112116); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (mmu:56322)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10611480;21750661", "class_list": "", "function": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SSL1;Q5SSL2;Q8QZU2;Q9JKW2", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQ85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AQL3-1", "uniprot_id": [ { "id": "TM235_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AQL3", "type": "external" } ], "mass": 21957.0, "length": 211, "protein_name": "Transmembrane protein 235", "gene_name": "Tmem235", "organism": "Mouse", "refseq_name": "transmembrane protein 235 precursor", "refseq_ac": [ { "id": "NP_001079004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001079004", "type": "external" } ], "gene_names_uniprotkb": "Tmem235; Cldn27; Gm12581", "gene_names_refseq": "Cldn27; Gm12581; Tmem235", "protein_names_uniprotkb": "Transmembrane protein 235; Claudin-27", "protein_names_refseq": "claudin-27; transmembrane protein 235 precursor; transmembrane protein ENSP00000364084 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:546519)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21276448;21689651;30084848", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1AQL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AXP6-1", "uniprot_id": [ { "id": "TOM5_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AXP6", "type": "external" } ], "mass": 6037.0, "length": 51, "protein_name": "Mitochondrial import receptor subunit TOM5 homolog", "gene_name": "Tomm5", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM5 homolog isoform 1", "refseq_ac": [ { "id": "NP_001093145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093145", "type": "external" } ], "gene_names_uniprotkb": "Tomm5; Tom5", "gene_names_refseq": "1110019J04Rik; Tom5; Tomm5", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM5 homolog", "protein_names_refseq": "mitochondrial import receptor subunit TOM5 homolog isoform 1; mitochondrial import receptor subunit TOM5 homolog; translocase of outer mitochondrial membrane 5 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:68512); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22688586;22872234;30779550;34428180", "class_list": "", "function": "Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)., [UniProtKB, UniProtKB]; Spontaneous development of cryptogenic organizing (intra-alveolar fibrosis) pneumonia in Tomm5-/- mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AXP7;B1AXP8;B1AXP9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0015031 protein transport;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1AXP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG50-1", "uniprot_id": [ { "id": "TM169_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG50", "type": "external" } ], "mass": 33424.0, "length": 297, "protein_name": "Transmembrane protein 169", "gene_name": "Tmem169", "organism": "Mouse", "refseq_name": "transmembrane protein 169", "refseq_ac": [ { "id": "NP_780773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780773", "type": "external" } ], "gene_names_uniprotkb": "Tmem169", "gene_names_refseq": "A830020B06Rik; Tmem169", "protein_names_uniprotkb": "Transmembrane protein 169", "protein_names_refseq": "transmembrane protein 169", "tax_id": 10090, "disease": "", "pathway": " (mmu:271711)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ78-1", "uniprot_id": [ { "id": "TOPK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JJ78", "type": "external" } ], "mass": 36745.0, "length": 330, "protein_name": "Lymphokine-activated killer T-cell-originated protein kinase", "gene_name": "Pbk", "organism": "Mouse", "refseq_name": "lymphokine-activated killer T-cell-originated protein kinase", "refseq_ac": [ { "id": "NP_075698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075698", "type": "external" } ], "gene_names_uniprotkb": "Pbk; Topk", "gene_names_refseq": "2810434B10Rik; D14Ertd732e; Pbk; TOPK", "protein_names_uniprotkb": "Lymphokine-activated killer T-cell-originated protein kinase; 2.7.12.2; PDZ-binding kinase; T-LAK cell-originated protein kinase", "protein_names_refseq": "MAPKK-like protein kinase; T-LAK cell-originated protein kinase; lymphokine-activated killer T-cell-originated protein kinase", "tax_id": 10090, "disease": "", "pathway": " (mmu:52033)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10781613;21183079;21750661;29904102;31599954;33821572;34428180;34788229;39090602", "class_list": "", "function": "Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation., [RefSeq, PubMed]; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity)., [UniProtKB]; Prolactin-regulated Pbk is involved in pregnancy-induced beta-cell proliferation in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The oncogenic kinase TOPK upregulates in psoriatic keratinocytes and contributes to psoriasis progression by regulating neutrophils infiltration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q922V2;Q9D184", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0050728 negative regulation of inflammatory response;GO:0018107 peptidyl-threonine phosphorylation;GO:0018105 peptidyl-serine phosphorylation;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JJ78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLH8-1", "uniprot_id": [ { "id": "TMOD4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JLH8", "type": "external" } ], "mass": 39261.0, "length": 345, "protein_name": "Tropomodulin-4", "gene_name": "Tmod4", "organism": "Mouse", "refseq_name": "tropomodulin-4", "refseq_ac": [ { "id": "NP_057921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057921", "type": "external" } ], "gene_names_uniprotkb": "Tmod4", "gene_names_refseq": "MTMOD; Sk-Tmod; Tmod4", "protein_names_uniprotkb": "Tropomodulin-4; Sk-Tmod; Skeletal muscle tropomodulin", "protein_names_refseq": "skeletal muscle tropomodulin; tropomodulin-4", "tax_id": 10090, "disease": "", "pathway": " (mmu:50874); (R-MMU-390522)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10662549;20368620;21750661;24430868;26586224;38663275", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB]; Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle., [RefSeq, PubMed]; RNAi depletion of Tmod1 from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%., [RefSeq, PubMed]; The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis., [RefSeq, PubMed]; Tmod4 localizes to thin filament pointed ends in Tmod1-null embryonic muscle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0030016 myofibril;GO:0005737 cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0051694 pointed-end actin filament capping;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JLH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BXJ9-1", "uniprot_id": [ { "id": "TMM62_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BXJ9", "type": "external" } ], "mass": 72862.0, "length": 643, "protein_name": "Transmembrane protein 62", "gene_name": "Tmem62", "organism": "Mouse", "refseq_name": "transmembrane protein 62", "refseq_ac": [ { "id": "NP_780494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780494", "type": "external" } ], "gene_names_uniprotkb": "Tmem62", "gene_names_refseq": "B830009D23Rik; Tmem62", "protein_names_uniprotkb": "Transmembrane protein 62", "protein_names_refseq": "transmembrane protein 62", "tax_id": 10090, "disease": "", "pathway": " (mmu:96957)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30899004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2AQ55", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8BXJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60846-1", "uniprot_id": [ { "id": "TNR8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q60846", "type": "external" } ], "mass": 53216.0, "length": 498, "protein_name": "Tumor necrosis factor receptor superfamily member 8", "gene_name": "Tnfrsf8", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 8 precursor", "refseq_ac": [ { "id": "NP_033427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033427", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf8", "gene_names_refseq": "Cd30; D1S166E; Ki-1; Ki; Tnfrsf8", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Lymphocyte activation antigen CD30", "protein_names_refseq": "CD30L receptor; lymphocyte activation antigen CD30; tumor necrosis factor receptor superfamily member 8 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21941); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;34813503;37097292;38069862;8543792", "class_list": "", "function": "CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury., [RefSeq, PubMed]; CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection., [RefSeq, PubMed]; CD30 plays a role in T-dependent immune response and T cell proliferation., [RefSeq, PubMed]; Receptor for TNFSF8/CD30L (PubMed:8543792). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1L3C9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0032759 positive regulation of TRAIL production;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q60846-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1X9-1", "uniprot_id": [ { "id": "TM50B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1X9", "type": "external" } ], "mass": 17948.0, "length": 158, "protein_name": "Transmembrane protein 50B", "gene_name": "Tmem50b", "organism": "Mouse", "refseq_name": "transmembrane protein 50B isoform 1", "refseq_ac": [ { "id": "NP_084294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084294", "type": "external" } ], "gene_names_uniprotkb": "Tmem50b", "gene_names_refseq": "B230114J08Rik; Tmem50b", "protein_names_uniprotkb": "Transmembrane protein 50B", "protein_names_refseq": "transmembrane protein 50B isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:77975)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18541381;21750661;34428180", "class_list": "", "function": "Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UZ98;Q8N7M9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D1X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR67-1", "uniprot_id": [ { "id": "TMM33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR67", "type": "external" } ], "mass": 28031.0, "length": 247, "protein_name": "Transmembrane protein 33", "gene_name": "Tmem33", "organism": "Mouse", "refseq_name": "transmembrane protein 33 isoform 1", "refseq_ac": [ { "id": "NP_001272381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001272381", "type": "external" } ], "gene_names_uniprotkb": "Tmem33; Db83", "gene_names_refseq": "1110006G02Rik; 1600019D15Rik; 2410089A21Rik; 2700052H22Rik; 5430406L04Rik; Tmem33; db83", "protein_names_uniprotkb": "Transmembrane protein 33; Protein DB83", "protein_names_refseq": "transmembrane protein 33 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67878)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "18250455;18299400;20173027;21750661;21952136;25428506;25428507;25605945;30084848;31048699;31219806;31599954;34428180;35820727;37453647;38821373", "class_list": "", "function": "Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]; MiR-29a-5p rescues depressive-like behaviors in a CUMS-induced mouse model by facilitating microglia M2-polarization in the prefrontal cortex via TMEM33 suppression., [RefSeq, PubMed]; Study shows that TMEM33 interacts with the ion channel polycystin-2 at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q544Q3;Q9D3M3;Q9DAV4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0016020 membrane", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0045087 innate immune response;GO:0061024 membrane organization;GO:1903896 positive regulation of IRE1-mediated unfolded protein response;GO:1903899 positive regulation of PERK-mediated unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9CR67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C4U2-1", "uniprot_id": [ { "id": "TM145_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C4U2", "type": "external" } ], "mass": 82473.0, "length": 746, "protein_name": "Transmembrane protein 145", "gene_name": "Tmem145", "organism": "Mouse", "refseq_name": "transmembrane protein 145 isoform 2 precursor", "refseq_ac": [ { "id": "NP_899134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899134", "type": "external" } ], "gene_names_uniprotkb": "Tmem145", "gene_names_refseq": "B930076A02Rik; Tmem145", "protein_names_uniprotkb": "Transmembrane protein 145", "protein_names_refseq": "transmembrane protein 145 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:330485)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;17114649;21750661", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0019236 response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8C4U2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39876-1", "uniprot_id": [ { "id": "TIMP3_MOUSE", "url": "https://www.uniprot.org/uniprot/P39876", "type": "external" } ], "mass": 24182.0, "length": 211, "protein_name": "Metalloproteinase inhibitor 3", "gene_name": "Timp3", "organism": "Mouse", "refseq_name": "metalloproteinase inhibitor 3 precursor", "refseq_ac": [ { "id": "NP_035725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035725", "type": "external" } ], "gene_names_uniprotkb": "Timp3; Sun; Timp-3", "gene_names_refseq": "Timp-3; Timp3", "protein_names_uniprotkb": "Metalloproteinase inhibitor 3; TIMP-3; Tissue inhibitor of metalloproteinases 3", "protein_names_refseq": "metalloproteinase inhibitor 3 precursor; metalloproteinase inhibitor 3; tissue inhibitor of metalloproteinases 3", "tax_id": 10090, "disease": "Sorsby's fundus dystrophy (Disease Ontology:DOID:0090114); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); preretinal fibrosis (Disease Ontology:DOID:2006); breast carcinoma (Disease Ontology:DOID:3459); choriocarcinoma (Disease Ontology:DOID:3594); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:21859); (R-MMU-114608)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10900194;12542794;15322543;21282576;21750661;26495903;26740625;37828378;38625414;39047907;7642607;7782289;7949367;8118794;8132674", "class_list": "", "function": "Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs) (PubMed:15322543, PubMed:21282576). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand. Selectively induces apoptosis in angiogenic endothelial cells through a caspase-independent cell death pathway. Mechanistically, inhibits matrix-induced focal adhesion kinase PTK2 tyrosine phosphorylation and association with paxillin/PXN and disrupts the incorporation of ITGB3, PTK2 and PXN into focal adhesion contacts on the matrix., [UniProtKB, PubMed, PubMed, UniProtKB]; TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91WL9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1901706 mesenchymal cell differentiation involved in bone development;GO:0034097 response to cytokine;GO:0009725 response to hormone;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P39876-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FJU9-1", "uniprot_id": [ { "id": "TMM40_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4FJU9", "type": "external" } ], "mass": 24926.0, "length": 225, "protein_name": "Transmembrane protein 40", "gene_name": "Tmem40", "organism": "Mouse", "refseq_name": "transmembrane protein 40 isoform a", "refseq_ac": [ { "id": "NP_001161728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161728", "type": "external" } ], "gene_names_uniprotkb": "Tmem40", "gene_names_refseq": "9030407H20Rik; Tmem40", "protein_names_uniprotkb": "Transmembrane protein 40", "protein_names_refseq": "transmembrane protein 40 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:94346)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21183079;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5D2;Q8VCR5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4FJU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69ZU6-1", "uniprot_id": [ { "id": "THS7A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69ZU6", "type": "external" } ], "mass": 183527.0, "length": 1645, "protein_name": "Thrombospondin type-1 domain-containing protein 7A", "gene_name": "Thsd7a", "organism": "Mouse", "refseq_name": "thrombospondin type-1 domain-containing protein 7A precursor", "refseq_ac": [ { "id": "NP_001158277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158277", "type": "external" } ], "gene_names_uniprotkb": "Thsd7a; Gm837; Kiaa0960", "gene_names_refseq": "Gm837; Thsd7a", "protein_names_uniprotkb": "Thrombospondin type-1 domain-containing protein 7A", "protein_names_refseq": "thrombospondin type-1 domain-containing protein 7A precursor; thrombospondin type-1 domain-containing protein 7A", "tax_id": 10090, "disease": "", "pathway": " (mmu:330267); (R-MMU-5173214)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;27214550;30899004;33300544;34428180", "class_list": "", "function": "Plays a role in actin cytoskeleton rearrangement., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 8, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 17, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q3TP01;Q3UWV1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0098846 podocyte foot;GO:0042995 cell projection", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q69ZU6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER58-1", "uniprot_id": [ { "id": "TICN2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER58", "type": "external" } ], "mass": 46863.0, "length": 423, "protein_name": "Testican-2", "gene_name": "Spock2", "organism": "Mouse", "refseq_name": "testican-2 precursor", "refseq_ac": [ { "id": "NP_443720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443720", "type": "external" } ], "gene_names_uniprotkb": "Spock2; Ticn2", "gene_names_refseq": "Gcap26; Spock2; mKIAA0275", "protein_names_uniprotkb": "Testican-2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2", "protein_names_refseq": "granule cell antiserum positive 26; testican-2 precursor; testican-2", "tax_id": 10090, "disease": "", "pathway": " (mmu:94214)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;15657052;21750661;30899004;38888196", "class_list": "glycogene", "function": "Both the proteoglycan and core protein forms of testican-2 inhibited neurite extension from cultured primary cerebellar neurons and may play regulatory roles in the development of the central nervous system., [RefSeq, PubMed]; May participate in diverse steps of neurogenesis. Binds calcium (By similarity)., [UniProtKB]; May participate in diverse steps of neurogenesis. Binds calcium., [UniProtKB, UniProtKB]; The novel prognostic marker SPOCK2 regulates tumour progression in melanoma., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 8, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0005539 glycosaminoglycan binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0010811 positive regulation of cell-substrate adhesion;GO:0010810 regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9ER58-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000001001.101.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZB9-1", "uniprot_id": [ { "id": "TM128_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZB9", "type": "external" } ], "mass": 19069.0, "length": 163, "protein_name": "Transmembrane protein 128", "gene_name": "Tmem128", "organism": "Mouse", "refseq_name": "transmembrane protein 128", "refseq_ac": [ { "id": "NP_079756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079756", "type": "external" } ], "gene_names_uniprotkb": "Tmem128", "gene_names_refseq": "2810021O14Rik; Tmem128", "protein_names_uniprotkb": "Transmembrane protein 128", "protein_names_refseq": "transmembrane protein 128", "tax_id": 10090, "disease": "", "pathway": " (mmu:66309)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BNQ8;Q9CYX2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER63-1", "uniprot_id": [ { "id": "TNR23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER63", "type": "external" } ], "mass": 19595.0, "length": 176, "protein_name": "Tumor necrosis factor receptor superfamily member 23", "gene_name": "Tnfrsf23", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 23 isoform 1 precursor", "refseq_ac": [ { "id": "NP_077252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077252", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf23; Dctrailr1; Tnfrh1; Tnfrsf1al1", "gene_names_refseq": "SOB; TNFRSFH23; Tnfrh1; Tnfrsf1al1; Tnfrsf23; mDcTRAILR1; mSOB", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 23; Decoy TRAIL receptor 1; TNF receptor family member SOB; TNF receptor homolog 1; Tumor necrosis factor receptor p60 homolog 1", "protein_names_refseq": "TNF receptor family member SOB; TNF receptor homolog 1; decoy TRAIL receptor 1; tumor necrosis factor receptor p60 homolog 1; tumor necrosis factor receptor superfamily member 23 isoform 1 precursor; tumor necrosis factor receptor superfamily, member 1a-like 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:79201)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11063728;12102730;12466268;19226377;21750661;25428506;30084848;34428180", "class_list": "", "function": "Apoptosis in experimental non-alcoholic steatohepatitis is associated with p53 activation and TRAIL receptor expression., [RefSeq, PubMed]; Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway., [UniProtKB, PubMed]; The Tnfrh1 gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHC0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ER63-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50592-1", "uniprot_id": [ { "id": "TNF10_MOUSE", "url": "https://www.uniprot.org/uniprot/P50592", "type": "external" } ], "mass": 33477.0, "length": 291, "protein_name": "Tumor necrosis factor ligand superfamily member 10", "gene_name": "Tnfsf10", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 10", "refseq_ac": [ { "id": "NP_033451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033451", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf10; Trail", "gene_names_refseq": "A330042I21Rik; APO-2L; Ly81; TL2; Tnfsf10; Tnlg6a; Trail", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 10; Protein TRAIL; TNF-related apoptosis-inducing ligand", "protein_names_refseq": "TNF-related apoptosis-inducing ligand; TRAIL/APO2L; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10", "tax_id": 10090, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); polycystic ovary syndrome (Disease Ontology:DOID:11612); arteriosclerosis (Disease Ontology:DOID:2349); osteoarthritis (Disease Ontology:DOID:8398); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:22035); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-69416); (R-MMU-75158)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "21750661;21952136;30084848;34428180;38273071;39365855;8777713", "class_list": "", "function": "Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis., [UniProtKB, UniProtKB]; The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL., [RefSeq, PubMed]; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0045569 TRAIL binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50592-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JR5-1", "uniprot_id": [ { "id": "TINAL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JR5", "type": "external" } ], "mass": 52665.0, "length": 466, "protein_name": "Tubulointerstitial nephritis antigen-like", "gene_name": "Tinagl1", "organism": "Mouse", "refseq_name": "tubulointerstitial nephritis antigen-like precursor", "refseq_ac": [ { "id": "NP_001161805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161805", "type": "external" } ], "gene_names_uniprotkb": "Tinagl1; Arg1; Lcn7; Tinagl", "gene_names_refseq": "1110021J17Rik; AZ-1; AZ1; Arg1; Lcn7; TARP; Tinagl1; Tinagl", "protein_names_uniprotkb": "Tubulointerstitial nephritis antigen-like; AZ-1; Adrenocortical zonation factor 1; Androgen-regulated gene 1 protein; TARP; Tubulointerstitial nephritis antigen-related protein", "protein_names_refseq": "adrenocortical zonation factor 1; androgen-regulated gene 1 protein; tubulointerstitial nephritis antigen-like precursor; tubulointerstitial nephritis antigen-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:94242)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11377975;12600995;17425658;19587330;21750661;35199864;35597451;37336990", "class_list": "", "function": "Collectively with the putative role of AZ-1 in the adrenocortical zonation, we propose that AZ-1 potentially regulates functions of adrenocortical and VSM cells by modulating cell-matrix interactions, [RefSeq, PubMed]; Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes., [RefSeq, PubMed]; Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling., [RefSeq, PubMed]; In mouse embryos, the expression of both Tinagl1 mRNA and TINAGL1 protein was increased just prior to implantation. During postimplantation, TINAGL1 expression was restricted to extraembryonic regions., [RefSeq, PubMed]; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQT9", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005764 lysosome;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99JR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PAQ9-1", "uniprot_id": [ { "id": "TMG3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PAQ9", "type": "external" } ], "mass": 25877.0, "length": 231, "protein_name": "Transmembrane gamma-carboxyglutamic acid protein 3", "gene_name": "Prrg3", "organism": "Mouse", "refseq_name": "transmembrane gamma-carboxyglutamic acid protein 3 precursor", "refseq_ac": [ { "id": "NP_001074604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074604", "type": "external" } ], "gene_names_uniprotkb": "Prrg3; Gm368; Tmg3", "gene_names_refseq": "Gm368; Prrg3", "protein_names_uniprotkb": "Transmembrane gamma-carboxyglutamic acid protein 3; Proline-rich Gla protein 3; Proline-rich gamma-carboxyglutamic acid protein 3", "protein_names_refseq": "proline-rich Gla protein 3; proline-rich gamma-carboxyglutamic acid protein 3; transmembrane gamma-carboxyglutamic acid protein 3 precursor; transmembrane gamma-carboxyglutamic acid protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:208748)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "This gene encodes proline-rich gamma-carboxyglutamic acid protein 3, a member of vitamin K-dependent membrane proteins containing gamma-carboxyglutamic acid residues. The encoded precursor protein contains an N-terminal propeptide that is required for the carboxylation of glutamate residues in the mature protein. Alternate splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KGD9;B2RPV1", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PAQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1V4-1", "uniprot_id": [ { "id": "TMCO2_MOUSE", "url": "https://www.uniprot.org/uniprot/P0C1V4", "type": "external" } ], "mass": 20331.0, "length": 183, "protein_name": "Transmembrane and coiled-coil domain-containing protein 2", "gene_name": "Tmco2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmco2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:69469)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C1V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D702-1", "uniprot_id": [ { "id": "TMM52_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D702", "type": "external" } ], "mass": 21052.0, "length": 196, "protein_name": "Transmembrane protein 52", "gene_name": "Tmem52", "organism": "Mouse", "refseq_name": "transmembrane protein 52 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001240785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240785", "type": "external" } ], "gene_names_uniprotkb": "Tmem52", "gene_names_refseq": "2310043I08Rik; Tmem52", "protein_names_uniprotkb": "Transmembrane protein 52", "protein_names_refseq": "transmembrane protein 52 isoform 2 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:69671)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D702-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54907-1", "uniprot_id": [ { "id": "TNF12_MOUSE", "url": "https://www.uniprot.org/uniprot/O54907", "type": "external" } ], "mass": 27441.0, "length": 249, "protein_name": "Tumor necrosis factor ligand superfamily member 12", "gene_name": "Tnfsf12", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 12", "refseq_ac": [ { "id": "NP_035744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035744", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf12", "gene_names_refseq": "Apo3l; Dr3lg; Dr3l; Tnfsf12; Tweak", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 12; TNF-related weak inducer of apoptosis; TWEAK", "protein_names_refseq": "TNF-related weak inducer of apoptosis; tumor necrosis factor ligand superfamily member 12", "tax_id": 10090, "disease": "", "pathway": " (mmu:21944); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;12794080;12821115;12840022;21750661;36069059;37503908;38007933;9405449", "class_list": "", "function": "Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity)., [UniProtKB]; Characterization of murine TWEAK and TWEAK receptor (Fn14), [RefSeq, PubMed]; Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for gamma-secretase activity., [RefSeq, PubMed]; TWEAK is a novel physiological regulator of the non-canonical pathway for NF-kappaB activation, [RefSeq, PubMed]; TWEAK mediated the differentiation of RAW monocyte/macrophage cells into osteoclasts; propose that the biological effects of TWEAK are mediated by binding to one of at least two receptors that induce differential activation of downstream signal pathways GeneRIF: findings indicate that a second TweakR, TweakR2, exists on RAW cells and is responsible for mediating TWEAK-induced differentiation [TweakR2], [RefSeq, PubMed]; TWEAK promotes inflammatory response in liver fibrosis., [RefSeq, PubMed]; Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9CTP2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0006955 immune response;GO:0030154 cell differentiation;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0097191 extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O54907-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70157-1", "uniprot_id": [ { "id": "TOP3A_MOUSE", "url": "https://www.uniprot.org/uniprot/O70157", "type": "external" } ], "mass": 112358.0, "length": 1003, "protein_name": "DNA topoisomerase 3-alpha", "gene_name": "Top3a", "organism": "Mouse", "refseq_name": "DNA topoisomerase 3-alpha", "refseq_ac": [ { "id": "NP_033436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033436", "type": "external" } ], "gene_names_uniprotkb": "Top3a; Top3", "gene_names_refseq": "Top3a", "protein_names_uniprotkb": "DNA topoisomerase 3-alpha; 5.6.2.1; DNA topoisomerase III alpha", "protein_names_refseq": "DNA topoisomerase 3-alpha; DNA topoisomerase III alpha; Top IIIa; topoisomerase (DNA) 3 alpha; topoisomerase 3 alpha", "tax_id": 10090, "disease": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111524)", "pathway": " (mmu:21975); (R-MMU-5685938); (R-MMU-5685942); (R-MMU-5693537); (R-MMU-5693568); (R-MMU-5693579); (R-MMU-5693607); (R-MMU-5693616); (R-MMU-6804756); (R-MMU-69473)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "21750661;30084848;9540825", "class_list": "", "function": "Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. It is required for mtDNA decatenation and segregation after completion of replication, in a process that does not require BLM, RMI1 and RMI2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003697 single-stranded DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005759 mitochondrial matrix;GO:0016605 PML body;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000724 double-strand break repair via homologous recombination;GO:0006265 DNA topological change;GO:0051304 chromosome separation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70157-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DJF3-1", "uniprot_id": [ { "id": "TMM95_MOUSE", "url": "https://www.uniprot.org/uniprot/P0DJF3", "type": "external" } ], "mass": 20158.0, "length": 176, "protein_name": "Sperm-egg fusion protein TMEM95", "gene_name": "Tmem95", "organism": "Mouse", "refseq_name": "sperm-egg fusion protein TMEM95 precursor", "refseq_ac": [ { "id": "NP_001182639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182639", "type": "external" } ], "gene_names_uniprotkb": "Tmem95", "gene_names_refseq": "432576; Tmem95", "protein_names_uniprotkb": "Sperm-egg fusion protein TMEM95; Transmembrane protein 95", "protein_names_refseq": "sperm-egg fusion protein TMEM95 precursor; sperm-egg fusion protein TMEM95", "tax_id": 10090, "disease": "", "pathway": " (mmu:100503361)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "32393636;32484434;34982145", "class_list": "", "function": "Sperm protein required for fusion of sperm with the egg membrane during fertilization., [UniProtKB, PubMed, PubMed, PubMed]; Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice., [RefSeq, PubMed]; TMEM95 is a sperm membrane protein essential for mammalian fertilization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097524 sperm plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DJF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20801-1", "uniprot_id": [ { "id": "TNNC2_MOUSE", "url": "https://www.uniprot.org/uniprot/P20801", "type": "external" } ], "mass": 18110.0, "length": 160, "protein_name": "Troponin C, skeletal muscle", "gene_name": "Tnnc2", "organism": "Mouse", "refseq_name": "troponin C, skeletal muscle", "refseq_ac": [ { "id": "NP_033420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033420", "type": "external" } ], "gene_names_uniprotkb": "Tnnc2; Tncs", "gene_names_refseq": "Tncs; Tnnc2", "protein_names_uniprotkb": "Troponin C, skeletal muscle; STNC", "protein_names_refseq": "STNC; troponin C, fast skeletal; troponin C, skeletal muscle", "tax_id": 10090, "disease": "congenital myopathy 15 (Disease Ontology:DOID:0081347)", "pathway": " (mmu:21925); (R-MMU-390522)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2394755;39927985", "class_list": "", "function": "Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20801-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41539-1", "uniprot_id": [ { "id": "TKN1_MOUSE", "url": "https://www.uniprot.org/uniprot/P41539", "type": "external" } ], "mass": 15045.0, "length": 130, "protein_name": "Protachykinin-1", "gene_name": "Tac1", "organism": "Mouse", "refseq_name": "protachykinin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_033337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033337", "type": "external" } ], "gene_names_uniprotkb": "Tac1; Nka; Nkna; Tac2", "gene_names_refseq": "4930528L02Rik; NK-1; NK1; Nkna; PPT-A; PPTA; SP; Tac1", "protein_names_uniprotkb": "Protachykinin-1; Neuromedin L; PPT; Substance K", "protein_names_refseq": "neurokinin 1; neurokinin A; preprotachykinin A; protachykinin-1 isoform 1 precursor; protachykinin-1; substance P", "tax_id": 10090, "disease": "colitis (Disease Ontology:DOID:0060180); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432); central sleep apnea (Disease Ontology:DOID:9220)", "pathway": " (mmu:21333); (R-MMU-380095); (R-MMU-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1708336;21750661;28219706;30686732", "class_list": "", "function": "Is a ligand for Tacr1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding to Tacr1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is also a TACR3 agonist with low receptor affinity. Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:30686732). Acts as a ligand for Mrgprb2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (PubMed:30686732). The inflammatory response can then activate or sensitize nociceptors, promoting pain (PubMed:30686732). Also acts as a ligand for Mrgpra1 receptor in mast cells, initiating a signaling that elicits itch (PubMed:30686732)., [UniProtKB, PubMed, UniProtKB]; Is a ligand for Tacr2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Binding to Tacr2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP)., [UniProtKB, UniProtKB]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q00073", "ec_number_list": [], "go_molecular_function": "GO:0031835 substance P receptor binding;GO:0031837 substance K receptor binding;GO:0005184 neuropeptide hormone activity;GO:0048018 receptor ligand activity;GO:0031836 neuromedin K receptor binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0001878 response to yeast;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41539-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62073-1", "uniprot_id": [ { "id": "TIM10_MOUSE", "url": "https://www.uniprot.org/uniprot/P62073", "type": "external" } ], "mass": 10333.0, "length": 90, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "Timm10", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim10", "refseq_ac": [ { "id": "NP_038927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038927", "type": "external" } ], "gene_names_uniprotkb": "Timm10; Tim10", "gene_names_refseq": "Tim13; Timm10; Timm13a", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim10; translocase of inner mitochondrial membrane 10 homolog; translocase of inner mitochondrial membrane 13 homolog a", "tax_id": 10090, "disease": "", "pathway": " (mmu:30059)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10611480;25428506;31219806;32848054;34428180", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WV99;Q9WVA0;Q9Y5J8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62073-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5Y3-1", "uniprot_id": [ { "id": "TPPP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q0P5Y3", "type": "external" } ], "mass": 18681.0, "length": 170, "protein_name": "Tubulin polymerization-promoting protein family member 2", "gene_name": "Tppp2", "organism": "Mouse", "refseq_name": "tubulin polymerization-promoting protein family member 2", "refseq_ac": [ { "id": "NP_001122106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122106", "type": "external" } ], "gene_names_uniprotkb": "Tppp2; Gm77", "gene_names_refseq": "Gm1790; Gm77; Tppp2", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein family member 2", "protein_names_refseq": "p25 beta; tubulin polymerization-promoting protein family member 2", "tax_id": 10090, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (mmu:219038)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18424439;30680919;34231842;35820727", "class_list": "", "function": "Deficiency of TPPP2 might affect the translation of specific proteins, such as eEf1b, altering the structure and function of sperm mitochondria, and resulting in decreased sperm count, motility and fertility., [RefSeq, PubMed]; Foxo3 represses ROS in part via regulation of ATM and this repression is required for maintenance of the hematopoietic stem cell pool, [RefSeq, PubMed]; Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001578 microtubule bundle formation;GO:0032273 positive regulation of protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0P5Y3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14C59-1", "uniprot_id": [ { "id": "TM11B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14C59", "type": "external" } ], "mass": 46713.0, "length": 416, "protein_name": "Transmembrane protease serine 11B-like protein", "gene_name": "Tmprss11b", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11B-like protein", "refseq_ac": [ { "id": "NP_795998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_795998", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11b; Hatl5; Tmprss11bnl", "gene_names_refseq": "9930019B18Rik; Tmprss11bnl; Tmprss11b", "protein_names_uniprotkb": "Transmembrane protease serine 11B-like protein; 3.4.21.-; Airway trypsin-like protease 5; Transmembrane protease serine 11B", "protein_names_refseq": "airway trypsin-like protease 5; transmembrane protease serine 11B-like protein; transmembrane protease, serine 11b N terminal like", "tax_id": 10090, "disease": "", "pathway": " (mmu:319875)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15328353;24498351;25428506", "class_list": "", "function": "Serine protease., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8BZ13;Q8BZ30", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q14C59-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32NZ6-1", "uniprot_id": [ { "id": "TMC5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q32NZ6", "type": "external" } ], "mass": 111070.0, "length": 967, "protein_name": "Transmembrane channel-like protein 5", "gene_name": "Tmc5", "organism": "Mouse", "refseq_name": "transmembrane channel-like protein 5 isoform a", "refseq_ac": [ { "id": "NP_001098722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098722", "type": "external" } ], "gene_names_uniprotkb": "Tmc5", "gene_names_refseq": "4932443L08Rik; Tmc5", "protein_names_uniprotkb": "Transmembrane channel-like protein 5", "protein_names_refseq": "transmembrane channel-like protein 5 isoform a; transmembrane channel-like protein 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:74424)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;12812529;12906855;21750661;39627609", "class_list": "", "function": "Probable component of an ion channel (Probable). Molecular function hasn't been characterized yet (Probable)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN61;Q80VR0;Q9D4F1", "ec_number_list": [], "go_molecular_function": "GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q32NZ6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KQJ0-1", "uniprot_id": [ { "id": "TMM69_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3KQJ0", "type": "external" } ], "mass": 27313.0, "length": 245, "protein_name": "Transmembrane protein 69", "gene_name": "Tmem69", "organism": "Mouse", "refseq_name": "transmembrane protein 69", "refseq_ac": [ { "id": "NP_808338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808338", "type": "external" } ], "gene_names_uniprotkb": "Tmem69", "gene_names_refseq": "A630048M13Rik; Tmem69", "protein_names_uniprotkb": "Transmembrane protein 69", "protein_names_refseq": "transmembrane protein 69", "tax_id": 10090, "disease": "", "pathway": " (mmu:230657)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ACZ7;Q8C9K2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KQJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UPR7-1", "uniprot_id": [ { "id": "TM102_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UPR7", "type": "external" } ], "mass": 54923.0, "length": 509, "protein_name": "Transmembrane protein 102", "gene_name": "Tmem102", "organism": "Mouse", "refseq_name": "transmembrane protein 102", "refseq_ac": [ { "id": "NP_001028605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028605", "type": "external" } ], "gene_names_uniprotkb": "Tmem102", "gene_names_refseq": "4632403M07Rik; Cbap; Tmem102-ps; Tmem102", "protein_names_uniprotkb": "Transmembrane protein 102", "protein_names_refseq": "transmembrane protein 102, pseudogene; transmembrane protein 102", "tax_id": 10090, "disease": "", "pathway": " (mmu:380705)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;17828305;23620790;25393474;34428180", "class_list": "", "function": "CBAP indeed can function as a novel signaling component within the ZAP70/Vav1/talin complex and plays an important role in regulating chemokine-promoted T-cell trafficking. Publication Status: Online-Only, [RefSeq, PubMed]; CBAP is a novel component in the TCR signaling pathway, and it modulates thymocyte apoptosis during negative selection. Publication Status: Online-Only, [RefSeq, PubMed]; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway., [UniProtKB]; Shows functional evidence for the homologous human protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9Q2B4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0010820 positive regulation of T cell chemotaxis;GO:0045785 positive regulation of cell adhesion;GO:2000406 positive regulation of T cell migration;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3UPR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UUA0-1", "uniprot_id": [ { "id": "LHPL7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UUA0", "type": "external" } ], "mass": 20752.0, "length": 195, "protein_name": "LHFPL tetraspan subfamily member 7 protein", "gene_name": "Lhfpl7", "organism": "Mouse", "refseq_name": "LHFPL tetraspan subfamily member 7 protein precursor", "refseq_ac": [ { "id": "NP_001028600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028600", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl7; Gm854; Tmem211", "gene_names_refseq": "Gm854; Lhfpl7; Tmem211", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 7 protein; Transmembrane protein 211", "protein_names_refseq": "LHFPL tetraspan subfamily member 7 protein precursor; LHFPL tetraspan subfamily member 7 protein; transmembrane protein 211", "tax_id": 10090, "disease": "", "pathway": " (mmu:333048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EJN6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3UUA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V209-1", "uniprot_id": [ { "id": "TMUB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V209", "type": "external" } ], "mass": 33808.0, "length": 319, "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 2", "gene_name": "Tmub2", "organism": "Mouse", "refseq_name": "transmembrane and ubiquitin-like domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001289434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289434", "type": "external" } ], "gene_names_uniprotkb": "Tmub2", "gene_names_refseq": "2010008E23Rik; Tmub2", "protein_names_uniprotkb": "Transmembrane and ubiquitin-like domain-containing protein 2", "protein_names_refseq": "transmembrane and ubiquitin-like domain-containing protein 2 isoform 1; transmembrane and ubiquitin-like domain-containing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72053)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;31219806", "class_list": "", "function": "This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2AWT1;Q8K0X0;Q91YQ0;Q9D8C5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3V209-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D777-1", "uniprot_id": [ { "id": "TNF13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D777", "type": "external" } ], "mass": 26889.0, "length": 241, "protein_name": "Tumor necrosis factor ligand superfamily member 13", "gene_name": "Tnfsf13", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 13 isoform 2", "refseq_ac": [ { "id": "NP_001152977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152977", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf13; April", "gene_names_refseq": "2310026N09Rik; April; Tall2; Tnfsf13; Tnlg7b; Trdl1", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL", "protein_names_refseq": "a proliferation-inducing ligand; tumor necrosis factor ligand 7b; tumor necrosis factor ligand superfamily member 13 isoform 2", "tax_id": 10090, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630)", "pathway": " (mmu:69583); (R-MMU-450520); (R-MMU-5669034)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10973284;12354377;15488762;15542592;21750661;36808499;37027297;38691538", "class_list": "", "function": "Anti-inflammatory role of APRIL by modulating regulatory B cells in antigen-induced arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth., [RefSeq, PubMed]; Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Review. Dendritic cell-derived TNF-family ligand APRIL enhances plasmablast survival and differentiation to plasma cells. Review article, [RefSeq, PubMed]; Spatial heterogeneity for APRIL production by eosinophils in the small intestine., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERP1", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0050776 regulation of immune response;GO:0002636 positive regulation of germinal center formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D777-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWI3-1", "uniprot_id": [ { "id": "CEIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWI3", "type": "external" } ], "mass": 153801.0, "length": 1383, "protein_name": "Cell surface hyaluronidase", "gene_name": "Cemip2", "organism": "Mouse", "refseq_name": "cell surface hyaluronidase", "refseq_ac": [ { "id": "NP_001028931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028931", "type": "external" } ], "gene_names_uniprotkb": "Cemip2; Kiaa1412; Tmem2", "gene_names_refseq": "Cemip2; Tmem2", "protein_names_uniprotkb": "Cell surface hyaluronidase; 3.2.1.35; Cell migration-inducing hyaluronidase 2; Transmembrane protein 2", "protein_names_refseq": "cell surface hyaluronidase; transmembrane protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:83921)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10.1101/2023.09.13.557529;10767548;19144319;19349973;19656770;21183079;21750661;21896629;26495903;28246172;30084848;30899004;31219806;32152506;33647313;34624311;35820727;37196767;37449307;37527776;37828378;38159864;38378757", "class_list": "glycogene;glycosylhydrolase", "function": "Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172, PubMed:37196767, PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (PubMed:33647313, PubMed:34624311). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM2 inhibits the development of Graves' orbitopathy through the JAK-STAT signaling pathway., [RefSeq, PubMed]; TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity., [RefSeq, PubMed]; Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 11, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 68, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 14, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3UE15;Q3UE98;Q6DFZ0;Q6ZPR7;Q8VE53;Q9QY22", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:1903670 regulation of sprouting angiogenesis;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q5FWI3-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.1000000000001.100.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4D9-1", "uniprot_id": [ { "id": "THOC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5U4D9", "type": "external" } ], "mass": 37315.0, "length": 341, "protein_name": "THO complex subunit 6 homolog", "gene_name": "Thoc6", "organism": "Mouse", "refseq_name": "THO complex subunit 6 homolog", "refseq_ac": [ { "id": "NP_001008425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008425", "type": "external" } ], "gene_names_uniprotkb": "Thoc6; Wdr58", "gene_names_refseq": "F830014G06Rik; Thoc6; Wdr58", "protein_names_uniprotkb": "THO complex subunit 6 homolog; WD repeat-containing protein 58", "protein_names_refseq": "THO complex subunit 6 homolog; WD repeat domain 58; WD repeat-containing protein 58", "tax_id": 10090, "disease": "", "pathway": " (mmu:386612); (R-MMU-159236); (R-MMU-72187)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21750661;25605945;31219806;34428180", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000347 THO complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U4D9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61382-1", "uniprot_id": [ { "id": "TRAF4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q61382", "type": "external" } ], "mass": 53504.0, "length": 470, "protein_name": "TNF receptor-associated factor 4", "gene_name": "Traf4", "organism": "Mouse", "refseq_name": "TNF receptor-associated factor 4", "refseq_ac": [ { "id": "NP_033449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033449", "type": "external" } ], "gene_names_uniprotkb": "Traf4; Cart1", "gene_names_refseq": "A530032M13Rik; CART1; Traf4; msp2", "protein_names_uniprotkb": "TNF receptor-associated factor 4; 2.3.2.27; Cysteine-rich motif associated to RING and Traf domains protein 1", "protein_names_refseq": "TNF receptor-associated factor 4; cysteine-rich motif associated to RING and Traf domains protein 1", "tax_id": 10090, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (mmu:22032)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10934170;11275257;11943846;16157600;18284467;21183079;23542741;25428506;36622335;37607012;37642020;9507120", "class_list": "", "function": "Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (By similarity). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (By similarity)., [UniProtKB, UniProtKB]; De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation., [RefSeq, PubMed]; Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Erratum:[Proc Natl Acad Sci U S A 2002 Jun11;99(12):8457], [RefSeq, PubMed]; TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the Activation of the AKT Pathway., [RefSeq, PubMed]; TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BHD9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0031996 thioesterase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q61382-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62288-1", "uniprot_id": [ { "id": "TICN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62288", "type": "external" } ], "mass": 49551.0, "length": 442, "protein_name": "Testican-1", "gene_name": "Spock1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spock1; Spock; Ticn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Testican-1; Protein SPOCK", "protein_names_refseq": "", "tax_id": 10090, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21750661;33300544;8626787", "class_list": "glycogene", "function": "May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9PYW3", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0001764 neuron migration;GO:0010977 negative regulation of neuron projection development;GO:0010812 negative regulation of cell-substrate adhesion;GO:0022008 neurogenesis;GO:0021953 central nervous system neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62288-1", "record_type": "protein", "filter_code": "0000000.1000110.100000.000000000000100000.0100000001000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63739-1", "uniprot_id": [ { "id": "TP4A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q63739", "type": "external" } ], "mass": 19815.0, "length": 173, "protein_name": "Protein tyrosine phosphatase type IVA 1", "gene_name": "Ptp4a1", "organism": "Mouse", "refseq_name": "protein tyrosine phosphatase type IVA 1 isoform 1", "refseq_ac": [ { "id": "NP_035330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035330", "type": "external" } ], "gene_names_uniprotkb": "Ptp4a1; Prl1", "gene_names_refseq": "C130021B01; Prl-1; Ptp4a1", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 1; 3.1.3.48; PRL-1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1", "protein_names_refseq": "protein tyrosine phosphatase type IVA 1 isoform 1; protein tyrosine phosphatase type IVA 1; protein-tyrosine phosphatase of regenerating liver 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:19243)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10.1101/2023.09.13.557529;10194868;10747914;11278933;21750661;31219806;34428180;35077201;36534975", "class_list": "", "function": "Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-kappaB inactivation., [RefSeq, PubMed]; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity)., [UniProtKB]; The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09097;O09154;Q3UFU9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63739-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P2B1-1", "uniprot_id": [ { "id": "TNPO3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P2B1", "type": "external" } ], "mass": 104170.0, "length": 923, "protein_name": "Transportin-3", "gene_name": "Tnpo3", "organism": "Mouse", "refseq_name": "transportin-3 isoform 2", "refseq_ac": [ { "id": "NP_001334008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334008", "type": "external" } ], "gene_names_uniprotkb": "Tnpo3", "gene_names_refseq": "5730544L10Rik; C430013M08Rik; D6Ertd313e; Tnpo3; Trn-SR; mKIAA4133", "protein_names_uniprotkb": "Transportin-3", "protein_names_refseq": "transportin-3 isoform 2; transportin-SR", "tax_id": 10090, "disease": "autosomal dominant limb-girdle muscular dystrophy type 2 (Disease Ontology:DOID:0110304)", "pathway": " (mmu:320938)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "15345747;18299400;20484733;21750661;25428506;28135057;30084848;30779550;33300544;33452620;33649389;34203471;34428180;35820727;36167471", "class_list": "", "function": "Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus., [UniProtKB, UniProtKB]; Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis., [RefSeq, PubMed]; Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSL6;Q8BKX4;Q8BP42", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005642 annulate lamellae", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q6P2B1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PFX9-1", "uniprot_id": [ { "id": "TNKS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6PFX9", "type": "external" } ], "mass": 140944.0, "length": 1320, "protein_name": "Poly [ADP-ribose] polymerase tankyrase-1", "gene_name": "Tnks", "organism": "Mouse", "refseq_name": "poly [ADP-ribose] polymerase tankyrase-1", "refseq_ac": [ { "id": "NP_780300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780300", "type": "external" } ], "gene_names_uniprotkb": "Tnks; Tnks1", "gene_names_refseq": "4930554K12Rik; ARTD5; D130072O21Rik; Parp5a; TANK1; Tnks; mTNKS1", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase tankyrase-1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; Protein poly-ADP-ribosyltransferase tankyrase-1; TANK1; TRF1-interacting ankyrin-related ADP-ribose polymerase 1; Tankyrase I; Tankyrase-1", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 5; TRF1-interacting ankyrin-related ADP-ribose polymerase 1; poly [ADP-ribose] polymerase tankyrase-1; protein poly-ADP-ribosyltransferase tankyrase-1; tankyrase I; tankyrase-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:21951); (R-MMU-201681); (R-MMU-4641257); (R-MMU-5689880); (R-MMU-8948751)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "17026964;17059388;21750661;24788674;29187734;34428180;35362478;37607510", "class_list": "", "function": "Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation., [RefSeq, PubMed]; Insulin-stimulated insulin-responsive aminopeptidase translocation remained intact despite substantial GLUT4 knockdown, [RefSeq, PubMed]; MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1., [RefSeq, PubMed]; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity., [UniProtKB, UniProtKB]; Tankyrase represses autoinflammation through the attenuation of TLR2 signaling., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BX62", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0032212 positive regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PFX9-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M711-1", "uniprot_id": [ { "id": "TR113_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M711", "type": "external" } ], "mass": 36376.0, "length": 309, "protein_name": "Taste receptor type 2 member 113", "gene_name": "Tas2r113", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 113", "refseq_ac": [ { "id": "NP_996901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996901", "type": "external" } ], "gene_names_uniprotkb": "Tas2r113; T2r58", "gene_names_refseq": "T2R13; Tas2r113; Tas2r13; mGR13; mt2r58", "protein_names_uniprotkb": "Taste receptor type 2 member 113; T2R113; mT2R58", "protein_names_refseq": "T2R113; taste receptor type 2 member 113", "tax_id": 10090, "disease": "", "pathway": " (mmu:387345)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12679530", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M711-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M712-1", "uniprot_id": [ { "id": "TR110_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M712", "type": "external" } ], "mass": 37837.0, "length": 333, "protein_name": "Taste receptor type 2 member 110", "gene_name": "Tas2r110", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 110", "refseq_ac": [ { "id": "NP_954606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954606", "type": "external" } ], "gene_names_uniprotkb": "Tas2r110", "gene_names_refseq": "T2R10; Tas2r10; Tas2r110; mt2r57", "protein_names_uniprotkb": "Taste receptor type 2 member 110; STC 9-1; T2R110; mT2r57", "protein_names_refseq": "T2R110; taste receptor type 2 member 110", "tax_id": 10090, "disease": "", "pathway": " (mmu:387344)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11854532;12679530", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q71QD1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M721-1", "uniprot_id": [ { "id": "TR120_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M721", "type": "external" } ], "mass": 33594.0, "length": 295, "protein_name": "Taste receptor type 2 member 120", "gene_name": "Tas2r120", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 120", "refseq_ac": [ { "id": "NP_996906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996906", "type": "external" } ], "gene_names_uniprotkb": "Tas2r120; T2r47", "gene_names_refseq": "T2R20; Tas2r120; Tas2r20; mGR20; mt2r47", "protein_names_uniprotkb": "Taste receptor type 2 member 120; T2R120; mT2R47", "protein_names_refseq": "T2R120; taste receptor type 2 member 120", "tax_id": 10090, "disease": "", "pathway": " (mmu:387348); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12679530", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031514 motile cilium", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M721-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN60-1", "uniprot_id": [ { "id": "TMC6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN60", "type": "external" } ], "mass": 90546.0, "length": 810, "protein_name": "Transmembrane channel-like protein 6", "gene_name": "Tmc6", "organism": "Mouse", "refseq_name": "transmembrane channel-like protein 6", "refseq_ac": [ { "id": "NP_663414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663414", "type": "external" } ], "gene_names_uniprotkb": "Tmc6; Ever1", "gene_names_refseq": "D11Ertd204e; EVER1; Tmc6", "protein_names_uniprotkb": "Transmembrane channel-like protein 6", "protein_names_refseq": "transmembrane channel-like protein 6", "tax_id": 10090, "disease": "epidermodysplasia verruciformis (Disease Ontology:DOID:13777)", "pathway": " (mmu:217353); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12812529;12906855;18299400;20173027;21183079;21750661;21952136;24129315;25428506;25428507;30084848;31599954;32917726;34428180;35820727;38440182", "class_list": "", "function": "Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:32917726, PubMed:38440182). Together with its homolog TMC8/EVER2, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (PubMed:38440182)., [UniProtKB, UniProtKB, PubMed, PubMed]; Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B1ATB4;Q78JR7;Q7TQ68;Q8BP52;Q8C6Z5;Q99J32", "ec_number_list": [], "go_molecular_function": "GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q7TN60-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X59-1", "uniprot_id": [ { "id": "TMC5B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80X59", "type": "external" } ], "mass": 36059.0, "length": 307, "protein_name": "Transmembrane and coiled-coil domain-containing protein 5B", "gene_name": "Tmco5b", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domain-containing protein 5B", "refseq_ac": [ { "id": "NP_083508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083508", "type": "external" } ], "gene_names_uniprotkb": "Tmco5b", "gene_names_refseq": "4930563P21Rik; Tmco5b", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 5B", "protein_names_refseq": "transmembrane and coiled-coil domain-containing protein 5B", "tax_id": 10090, "disease": "", "pathway": " (mmu:75275)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30059200", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D4S7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80X59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGX0-1", "uniprot_id": [ { "id": "TRI23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGX0", "type": "external" } ], "mass": 63931.0, "length": 574, "protein_name": "E3 ubiquitin-protein ligase TRIM23", "gene_name": "Trim23", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM23 isoform 1", "refseq_ac": [ { "id": "NP_001348467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001348467", "type": "external" } ], "gene_names_uniprotkb": "Trim23; Arfd1", "gene_names_refseq": "6330516O20Rik; Arfd1; Trim23", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM23; 2.3.2.27; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23", "protein_names_refseq": "ADP-ribosylation factor domain protein 1, 64kD; ADP-ribosylation factor domain-containing protein 1; E3 ubiquitin-protein ligase TRIM23 isoform 1; E3 ubiquitin-protein ligase TRIM23; GTP-binding protein ARD-1; RING-type E3 ubiquitin transferase TRIM23; tripartite motif protein TRIM23; tripartite motif-containing protein 23", "tax_id": 10090, "disease": "", "pathway": " (mmu:81003)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25905670;36449224;40360474", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes., [UniProtKB, UniProtKB]; TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. Publication Status: Online-Only, [RefSeq, PubMed]; Tripartite motif containing 23 functions as a critical regulator in macrophages to control the pathological feature of diabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C2B6;Q8CDA4;Q8CDA7", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0010508 positive regulation of autophagy;GO:0016567 protein ubiquitination;GO:0016192 vesicle-mediated transport;GO:0031401 positive regulation of protein modification process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGX2-1", "uniprot_id": [ { "id": "TIM29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGX2", "type": "external" } ], "mass": 29415.0, "length": 266, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim29", "gene_name": "Timm29", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim29", "refseq_ac": [ { "id": "NP_848734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848734", "type": "external" } ], "gene_names_uniprotkb": "Timm29", "gene_names_refseq": "1810026J23Rik; TIM29; Timm29", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim29; TIM29", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim29; uncharacterized protein C19orf52 homolog", "tax_id": 10090, "disease": "Sengers syndrome (Disease Ontology:DOID:0080132)", "pathway": " (mmu:69773)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8BGX2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BM55-1", "uniprot_id": [ { "id": "TM214_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BM55", "type": "external" } ], "mass": 76430.0, "length": 687, "protein_name": "Transmembrane protein 214", "gene_name": "Tmem214", "organism": "Mouse", "refseq_name": "transmembrane protein 214", "refseq_ac": [ { "id": "NP_653108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653108", "type": "external" } ], "gene_names_uniprotkb": "Tmem214", "gene_names_refseq": "1110039B18Rik; 4921530J21Rik; Tmem214", "protein_names_uniprotkb": "Transmembrane protein 214", "protein_names_refseq": "transmembrane protein 214", "tax_id": 10090, "disease": "", "pathway": " (mmu:68796)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;34428180;35820727;37453647", "class_list": "", "function": "Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TLH3;Q3UPX9;Q78HK3;Q8R0D5;Q8R237;Q8VC05", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8BM55-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BPE4-1", "uniprot_id": [ { "id": "TM177_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BPE4", "type": "external" } ], "mass": 34067.0, "length": 311, "protein_name": "Transmembrane protein 177", "gene_name": "Tmem177", "organism": "Mouse", "refseq_name": "transmembrane protein 177", "refseq_ac": [ { "id": "NP_780315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780315", "type": "external" } ], "gene_names_uniprotkb": "Tmem177", "gene_names_refseq": "2300008B03Rik; Tmem177", "protein_names_uniprotkb": "Transmembrane protein 177", "protein_names_refseq": "transmembrane protein 177", "tax_id": 10090, "disease": "", "pathway": " (mmu:66343); (R-MMU-9864848)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BPE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQX5-1", "uniprot_id": [ { "id": "TMCO6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQX5", "type": "external" } ], "mass": 54915.0, "length": 494, "protein_name": "Transmembrane and coiled-coil domain-containing protein 6", "gene_name": "Tmco6", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domain-containing protein 6", "refseq_ac": [ { "id": "NP_082312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082312", "type": "external" } ], "gene_names_uniprotkb": "Tmco6", "gene_names_refseq": "2410015B03Rik; Tmco6", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 6", "protein_names_refseq": "transmembrane and coiled-coil domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:71983)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;34428180;38381538", "class_list": "", "function": "DNA of Neutrophil Extracellular Traps Binds TMCO6 to Impair CD8+ T-cell Immunity in Hepatocellular Carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99JV8;Q9CWP3", "ec_number_list": [], "go_molecular_function": "GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BQX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BRG8-1", "uniprot_id": [ { "id": "TM209_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BRG8", "type": "external" } ], "mass": 62982.0, "length": 561, "protein_name": "Transmembrane protein 209", "gene_name": "Tmem209", "organism": "Mouse", "refseq_name": "transmembrane protein 209 isoform 2", "refseq_ac": [ { "id": "NP_001298022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001298022", "type": "external" } ], "gene_names_uniprotkb": "Tmem209", "gene_names_refseq": "2700094F01Rik; Tmem209", "protein_names_uniprotkb": "Transmembrane protein 209", "protein_names_refseq": "transmembrane protein 209 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72649)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;22872234;25428506;31219806;34203471;34428180;36210013;40997131", "class_list": "", "function": "Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80WQ3;Q8BP02;Q8C202;Q8CDY5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BRG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX35-1", "uniprot_id": [ { "id": "TNR27_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX35", "type": "external" } ], "mass": 33066.0, "length": 297, "protein_name": "Tumor necrosis factor receptor superfamily member 27", "gene_name": "Eda2r", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 27", "refseq_ac": [ { "id": "NP_001154904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001154904", "type": "external" } ], "gene_names_uniprotkb": "Eda2r; Tnfrsf27; Xedar", "gene_names_refseq": "9430060M22Rik; Eda2r; TNFRSF27; Xedar", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; X-linked ectodysplasin-A2 receptor", "protein_names_refseq": "EDA-A2 receptor; X linked ectodysplasin receptor; X-linked ectodysplasin-A2 receptor; tumor necrosis factor receptor superfamily member 27", "tax_id": 10090, "disease": "", "pathway": " (mmu:245527); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14749376;38797667;38801457", "class_list": "", "function": "EDA-A2 transgenic mice exhibited multifocal myodegeneration; this phenotype was not observed in the absence of XEDAR, [RefSeq, PubMed]; EDA2R-NIK signaling in cancer cachexia. Review article, [RefSeq, PubMed]; Ectodysplasin-A2 receptor (EDA2R) knockdown alleviates myocardial ischemia/reperfusion injury through inhibiting the activation of the NF-kappaB signaling pathway., [RefSeq, PubMed]; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BM50", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005031 tumor necrosis factor receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0046330 positive regulation of JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BX35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C428-1", "uniprot_id": [ { "id": "TMC7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C428", "type": "external" } ], "mass": 83337.0, "length": 726, "protein_name": "Transmembrane channel-like protein 7", "gene_name": "Tmc7", "organism": "Mouse", "refseq_name": "transmembrane channel-like protein 7", "refseq_ac": [ { "id": "NP_766064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766064", "type": "external" } ], "gene_names_uniprotkb": "Tmc7", "gene_names_refseq": "1700030H01Rik; C230064B05; C630024K23Rik; Tmc7", "protein_names_uniprotkb": "Transmembrane channel-like protein 7", "protein_names_refseq": "transmembrane channel-like protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:209760)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;12812529;12906855;25428506;38568807;39269275", "class_list": "", "function": "Acts as an inhibitory modulator of Piezo2 mechanosensitive channel in dorsal root ganglion (DRG) neurons through physical interactions or interference with the interaction between PIEZO2 and the cytoskeleton., [UniProtKB, PubMed]; TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN59;Q7TQ66;Q8C4C3", "ec_number_list": [], "go_molecular_function": "GO:0008200 ion channel inhibitor activity;GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050954 sensory perception of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8C428-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C6V3-1", "uniprot_id": [ { "id": "TM212_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C6V3", "type": "external" } ], "mass": 20747.0, "length": 187, "protein_name": "Transmembrane protein 212", "gene_name": "Tmem212", "organism": "Mouse", "refseq_name": "transmembrane protein 212", "refseq_ac": [ { "id": "NP_001157909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157909", "type": "external" } ], "gene_names_uniprotkb": "Tmem212", "gene_names_refseq": "E030011K20Rik; Gm564; Tmem212", "protein_names_uniprotkb": "Transmembrane protein 212", "protein_names_refseq": "transmembrane protein 212", "tax_id": 10090, "disease": "", "pathway": " (mmu:208613)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VE21", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8C6V3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZL3-1", "uniprot_id": [ { "id": "THTPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8JZL3", "type": "external" } ], "mass": 24264.0, "length": 224, "protein_name": "Thiamine-triphosphatase", "gene_name": "Thtpa", "organism": "Mouse", "refseq_name": "thiamine-triphosphatase", "refseq_ac": [ { "id": "NP_694723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694723", "type": "external" } ], "gene_names_uniprotkb": "Thtpa", "gene_names_refseq": "Thtpa", "protein_names_uniprotkb": "Thiamine-triphosphatase; 3.6.1.28; ThTPase", "protein_names_refseq": "ThTPase; thiamine-triphosphatase", "tax_id": 10090, "disease": "", "pathway": " (mmu:105663); (R-MMU-196819)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15203116;18276586", "class_list": "", "function": "Analysis of the catalytic mechanism of mouse 25-kDa thiamine triphosphatase, [RefSeq, PubMed]; Hydrolase highly specific for thiamine triphosphate (ThTP)., [UniProtKB, PubMed]; The highest amount of mRNA was found in testis, followed by lung and muscle, while the highest enzyme activities were found in liver and kidney, [RefSeq, PubMed]; This gene encodes a cytosolic enzyme that catalyzes the conversion of thiamine triphosphate to thiamine diphosphate. The encoded protein requires divalent cations for enzymatic activity. The gene product is believed to play a role in regulation of thiamine triphosphate intracellular concentration, and it may be a messenger in cell signaling in response to cellular stress. [provided by RefSeq, Mar 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V1G2;Q8C3P9", "ec_number_list": [ { "id": "3.6.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.28", "type": "external" } ], "go_molecular_function": "GO:0050333 thiamine triphosphate phosphatase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0042357 thiamine diphosphate metabolic process;GO:0009229 thiamine diphosphate biosynthetic process;GO:0006772 thiamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JZL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K071-1", "uniprot_id": [ { "id": "TM221_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K071", "type": "external" } ], "mass": 23954.0, "length": 230, "protein_name": "Transmembrane protein 221", "gene_name": "Tmem221", "organism": "Mouse", "refseq_name": "transmembrane protein 221", "refseq_ac": [ { "id": "NP_001093932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093932", "type": "external" } ], "gene_names_uniprotkb": "Tmem221", "gene_names_refseq": "Tmem221", "protein_names_uniprotkb": "Transmembrane protein 221", "protein_names_refseq": "transmembrane protein 221", "tax_id": 10090, "disease": "", "pathway": " (mmu:434325)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RWI9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K071-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K0U3-1", "uniprot_id": [ { "id": "TMM17_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K0U3", "type": "external" } ], "mass": 22623.0, "length": 198, "protein_name": "Transmembrane protein 17", "gene_name": "Tmem17", "organism": "Mouse", "refseq_name": "transmembrane protein 17", "refseq_ac": [ { "id": "NP_705824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705824", "type": "external" } ], "gene_names_uniprotkb": "Tmem17", "gene_names_refseq": "Tmem17", "protein_names_uniprotkb": "Transmembrane protein 17", "protein_names_refseq": "transmembrane protein 17", "tax_id": 10090, "disease": "", "pathway": " (mmu:103765)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1101/2023.09.13.557529;22179047", "class_list": "", "function": "Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9803, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0060170 ciliary membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K0U3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1T0-1", "uniprot_id": [ { "id": "TMPS3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1T0", "type": "external" } ], "mass": 49506.0, "length": 453, "protein_name": "Transmembrane protease serine 3", "gene_name": "Tmprss3", "organism": "Mouse", "refseq_name": "transmembrane protease serine 3 isoform 2", "refseq_ac": [ { "id": "NP_542765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542765", "type": "external" } ], "gene_names_uniprotkb": "Tmprss3", "gene_names_refseq": "Tmprss3", "protein_names_uniprotkb": "Transmembrane protease serine 3; 3.4.21.-", "protein_names_refseq": "transmembrane protease serine 3 isoform 2; transmembrane proteinase serine 3", "tax_id": 10090, "disease": "autosomal recessive nonsyndromic deafness 8 (Disease Ontology:DOID:0110527); sensorineural hearing loss (Disease Ontology:DOID:10003); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (mmu:140765)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12393794;21454591;21750661;24924414;32186779", "class_list": "", "function": "Long noncoding RNA EBLN3P promotes the recovery of the function of impaired spiral ganglion neurons by competitively binding to miR2045p and regulating TMPRSS3 expression., [RefSeq, PubMed]; MiR-204 has a role in suppressing cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3, [RefSeq, PubMed]; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q812A6;Q8VDE0", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006883 intracellular sodium ion homeostasis;GO:0007605 sensory perception of sound;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K1T0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VC30-1", "uniprot_id": [ { "id": "TKFC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VC30", "type": "external" } ], "mass": 59691.0, "length": 578, "protein_name": "Triokinase/FMN cyclase", "gene_name": "Tkfc", "organism": "Mouse", "refseq_name": "triokinase/FMN cyclase isoform 1", "refseq_ac": [ { "id": "NP_663471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663471", "type": "external" } ], "gene_names_uniprotkb": "Tkfc; Dak", "gene_names_refseq": "Dak; Tkfc", "protein_names_uniprotkb": "Triokinase/FMN cyclase; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); FAD-AMP lyase (cyclic FMN forming); FMN cyclase; Glycerone kinase; Triokinase; Triose kinase", "protein_names_refseq": "bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); dihydroxyacetone kinase 2 homolog; triokinase/FMN cyclase isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:225913); (R-MMU-70350)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;30084848;31219806;34428180;35114011;37453647;38782732", "class_list": "", "function": "Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HNF4alpha is required for Tkfc promoter activation by ChREBP., [RefSeq, PubMed]; The TKFC Ala185Thr variant, reported as 'null' for fructose metabolism, is fully active as triokinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.28", "type": "external" }, { "id": "2.7.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.29", "type": "external" }, { "id": "4.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.15", "type": "external" } ], "go_molecular_function": "GO:0004371 glycerone kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0034012 FAD-AMP lyase (cyclizing) activity;GO:0050354 triokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0005975 carbohydrate metabolic process;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0039534 negative regulation of MDA-5 signaling pathway;GO:0045088 regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VC30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDX6-1", "uniprot_id": [ { "id": "RXLT1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VDX6", "type": "external" } ], "mass": 51386.0, "length": 444, "protein_name": "Ribitol-5-phosphate xylosyltransferase 1", "gene_name": "Rxylt1", "organism": "Mouse", "refseq_name": "ribitol-5-phosphate xylosyltransferase 1 isoform 1", "refseq_ac": [ { "id": "NP_694699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694699", "type": "external" } ], "gene_names_uniprotkb": "Rxylt1; Tmem5", "gene_names_refseq": "6330415D21Rik; Rxylt1; Tmem5", "protein_names_uniprotkb": "Ribitol-5-phosphate xylosyltransferase 1; 2.4.2.61; Transmembrane protein 5; UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase", "protein_names_refseq": "UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase; ribitol-5-phosphate xylosyltransferase 1 isoform 1; ribitol-5-phosphate xylosyltransferase 1; transmembrane protein 5", "tax_id": 10090, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); congenital muscular dystrophy-dystroglycanopathy type A10 (Disease Ontology:DOID:0111239)", "pathway": " (mmu:216395); (R-MMU-9939291)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "31219806", "class_list": "", "function": "Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan. Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R566", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.7.8.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.-", "type": "external" }, { "id": "2.4.2.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.61", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0120053 ribitol beta-1,4-xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:1902494 catalytic complex", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDX6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK8-1", "uniprot_id": [ { "id": "TM11D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VHK8", "type": "external" } ], "mass": 46254.0, "length": 417, "protein_name": "Transmembrane protease serine 11D", "gene_name": "Tmprss11d", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11D", "refseq_ac": [ { "id": "NP_663536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663536", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11d; Mat", "gene_names_refseq": "AST; AsP; Tmprss11d", "protein_names_uniprotkb": "Transmembrane protease serine 11D; 3.4.21.-; AT; Adrenal secretory serine protease; Airway trypsin-like protease; AsP", "protein_names_refseq": "AT; adrenal secretory serine protease; airway spesific trypsin-like protease; airway trypsin-like protease; transmembrane protease serine 11D", "tax_id": 10090, "disease": "", "pathway": " (mmu:231382)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14691009;21853097;24227843;37666068", "class_list": "", "function": "A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed., [RefSeq, PubMed]; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC., [UniProtKB, PubMed]; Predominantly expressed in upper gastrointestinal and respiratory tract-but also in adrenal gland. Complex expression pattern. Multifunctional role beyond adrenal proliferation., [RefSeq, PubMed]; TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNX3;Q8VDV1", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0040008 regulation of growth;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VP7-1", "uniprot_id": [ { "id": "TM101_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VP7", "type": "external" } ], "mass": 28783.0, "length": 257, "protein_name": "Transmembrane protein 101", "gene_name": "Tmem101", "organism": "Mouse", "refseq_name": "transmembrane protein 101", "refseq_ac": [ { "id": "NP_083925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083925", "type": "external" } ], "gene_names_uniprotkb": "Tmem101", "gene_names_refseq": "2610511E22Rik; Tmem101", "protein_names_uniprotkb": "Transmembrane protein 101", "protein_names_refseq": "transmembrane protein 101", "tax_id": 10090, "disease": "", "pathway": " (mmu:76547)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate NF-kappa-B signaling pathways., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CZW0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91VP7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91X86-1", "uniprot_id": [ { "id": "TMM98_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91X86", "type": "external" } ], "mass": 24684.0, "length": 226, "protein_name": "Transmembrane protein 98", "gene_name": "Tmem98", "organism": "Mouse", "refseq_name": "transmembrane protein 98", "refseq_ac": [ { "id": "NP_083813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083813", "type": "external" } ], "gene_names_uniprotkb": "Tmem98", "gene_names_refseq": "6530411B15Rik; Rwhs; Tmem98", "protein_names_uniprotkb": "Transmembrane protein 98", "protein_names_refseq": "transmembrane protein 98", "tax_id": 10090, "disease": "nanophthalmos (Disease Ontology:DOID:0080634)", "pathway": " (mmu:103743)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "25946230;30249802;31961879;32236127;37419942", "class_list": "", "function": "Findings highlight the importance of the interplay between TMEM98 and MYRF in determining the size of the eye Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation (PubMed:25946230). The secreted form promotes differentiation of T helper 1 cells (Th1) (PubMed:25946230)., [UniProtKB, PubMed]; Phenotypic consequences of a nanophthalmos-associated TMEM98 variant in human and mouse. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM98 membrane protein physically interacts with MYRF in the endoplasmic reticulum and subsequently blocks its self-cleavage., [RefSeq, PubMed]; TMEM98 reduces FRAT2 protein levels and, accordingly, inhibits the FRAT2-mediated induction of ss-catenin/TCF signalling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:1900181 negative regulation of protein localization to nucleus;GO:0060070 canonical Wnt signaling pathway;GO:0010467 gene expression;GO:0031642 negative regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91X86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Z5-1", "uniprot_id": [ { "id": "TRAM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q924Z5", "type": "external" } ], "mass": 43183.0, "length": 370, "protein_name": "Translocating chain-associated membrane protein 2", "gene_name": "Tram2", "organism": "Mouse", "refseq_name": "translocating chain-associated membrane protein 2", "refseq_ac": [ { "id": "NP_803128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803128", "type": "external" } ], "gene_names_uniprotkb": "Tram2", "gene_names_refseq": "C330003D03Rik; Tram2", "protein_names_uniprotkb": "Translocating chain-associated membrane protein 2", "protein_names_refseq": "translocating chain-associated membrane protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:170829)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14749390;17486635;30779550;34428180", "class_list": "glycogene", "function": "Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2., [RefSeq, PubMed]; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT)., [UniProtKB, UniProtKB]; TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 27, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0032964 collagen biosynthetic process;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q924Z5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LG1-1", "uniprot_id": [ { "id": "TMM51_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LG1", "type": "external" } ], "mass": 27398.0, "length": 249, "protein_name": "Transmembrane protein 51", "gene_name": "Tmem51", "organism": "Mouse", "refseq_name": "transmembrane protein 51", "refseq_ac": [ { "id": "NP_663377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663377", "type": "external" } ], "gene_names_uniprotkb": "Tmem51", "gene_names_refseq": "Tmem51", "protein_names_uniprotkb": "Transmembrane protein 51", "protein_names_refseq": "transmembrane protein 51", "tax_id": 10090, "disease": "", "pathway": " (mmu:214359)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17242355;19144319;21183079;26495903;26740625", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TPZ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99LG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PP6-1", "uniprot_id": [ { "id": "TR34A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PP6", "type": "external" } ], "mass": 55950.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase TRIM34A", "gene_name": "Trim34a", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM34A", "refseq_ac": [ { "id": "NP_109609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_109609", "type": "external" } ], "gene_names_uniprotkb": "Trim34a", "gene_names_refseq": "Trim34-1; Trim34a; Trim34", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM34A; 2.3.2.27; Tripartite motif-containing protein 34A", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM34A; tripartite motif protein 34; tripartite motif-containing 34; tripartite motif-containing protein 34A; tripartite motif-containing protein 34", "tax_id": 10090, "disease": "", "pathway": " (mmu:94094)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11331580;29187734;32094504", "class_list": "", "function": "Functions as antiviral protein and contributes to the defense against retroviral infections (By similarity). Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (By similarity). Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (By similarity). Plays an essential role in sustaining the integrity of the inner mucus layer in the colon by controlling the exocytosis of the major component of colonic mucus MUC2 from colonic goblet cells (PubMed:32094504)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PYZ4;F8VPK2;Q99PP4;Q99PP5", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016567 protein ubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99PP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG0-1", "uniprot_id": [ { "id": "TMED6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG0", "type": "external" } ], "mass": 27673.0, "length": 239, "protein_name": "Transmembrane emp24 domain-containing protein 6", "gene_name": "Tmed6", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 6 precursor", "refseq_ac": [ { "id": "NP_079734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079734", "type": "external" } ], "gene_names_uniprotkb": "Tmed6", "gene_names_refseq": "1810015P03Rik; 1810018I24Rik; Tmed6", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 6; p24 family protein gamma-5; p24gamma5", "protein_names_refseq": "p24 family protein gamma-5; p24gamma5; transmembrane emp24 domain-containing protein 6 precursor; transmembrane emp24 domain-containing protein 6; transmembrane emp24 protein transport domain containing 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66269)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22129529;39927985", "class_list": "", "function": "Data show that TMED6 mRNA is highly and selectively expressed in pancreas,and knockdown of TMED6 gene expression in Min6 beta cells decreased insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQG0-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQN6-1", "uniprot_id": [ { "id": "TM14C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQN6", "type": "external" } ], "mass": 11642.0, "length": 114, "protein_name": "Transmembrane protein 14C", "gene_name": "Tmem14c", "organism": "Mouse", "refseq_name": "transmembrane protein 14C isoform 1", "refseq_ac": [ { "id": "NP_079663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079663", "type": "external" } ], "gene_names_uniprotkb": "Tmem14c", "gene_names_refseq": "1110021D01Rik; HSPC194; Tmem14c", "protein_names_uniprotkb": "Transmembrane protein 14C", "protein_names_refseq": "transmembrane protein 14C isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:66154)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16393994;19656490;25157825;31219806;34428180", "class_list": "", "function": "Required for functional heme biosynthesis in erythroid cells., [RefSeq, PubMed]; Required for normal heme biosynthesis., [UniProtKB]; TMEM14C facilitates the import of protoporphyrinogen IX into the mitochondrial matrix for heme synthesis and subsequent hemoglobin production, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q543H6;Q9D849", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006839 mitochondrial transport;GO:0030218 erythrocyte differentiation;GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9CQN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQV7-1", "uniprot_id": [ { "id": "TIM14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQV7", "type": "external" } ], "mass": 12437.0, "length": 116, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM14", "gene_name": "Dnajc19", "organism": "Mouse", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM14 isoform 2", "refseq_ac": [ { "id": "NP_001021382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021382", "type": "external" } ], "gene_names_uniprotkb": "Dnajc19; Tim14; Timm14", "gene_names_refseq": "1810055D05Rik; Dnajc19; Tim14", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM14; DnaJ homolog subfamily C member 19", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 19; mitochondrial import inner membrane translocase subunit TIM14 isoform 2; mitochondrial import inner membrane translocase subunit TIM14", "tax_id": 10090, "disease": "3-methylglutaconic aciduria type 5 (Disease Ontology:DOID:0110000)", "pathway": " (mmu:67713)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "21750661;24856930;26495903;28935714;37507081;37828378", "class_list": "", "function": "Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (PubMed:24856930). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1N1;Q9D896", "ec_number_list": [], "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099617 matrix side of mitochondrial inner membrane;GO:0001405 PAM complex, Tim23 associated import motor;GO:0098800 inner mitochondrial membrane protein complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0048806 genitalia development;GO:0007601 visual perception;GO:0030150 protein import into mitochondrial matrix;GO:1900208 regulation of cardiolipin metabolic process;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9CQV7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR02-1", "uniprot_id": [ { "id": "TMA16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR02", "type": "external" } ], "mass": 25782.0, "length": 221, "protein_name": "Translation machinery-associated protein 16", "gene_name": "Tma16", "organism": "Mouse", "refseq_name": "translation machinery-associated protein 16 isoform 1", "refseq_ac": [ { "id": "NP_079741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079741", "type": "external" } ], "gene_names_uniprotkb": "Tma16", "gene_names_refseq": "1810029B16Rik; Tma16", "protein_names_uniprotkb": "Translation machinery-associated protein 16", "protein_names_refseq": "UPF0534 protein C4orf43 homolog; translation machinery-associated protein 16 isoform 1; translation machinery-associated protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:66282)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit in the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05DD8", "ec_number_list": [], "go_molecular_function": "GO:1990275 preribosome binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CR02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CR96-1", "uniprot_id": [ { "id": "TM208_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CR96", "type": "external" } ], "mass": 19624.0, "length": 173, "protein_name": "Transmembrane protein 208", "gene_name": "Tmem208", "organism": "Mouse", "refseq_name": "transmembrane protein 208 isoform 3", "refseq_ac": [ { "id": "NP_079762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079762", "type": "external" } ], "gene_names_uniprotkb": "Tmem208", "gene_names_refseq": "1700006C06Rik; 2610030K20Rik; Hspc171; Tmem208", "protein_names_uniprotkb": "Transmembrane protein 208", "protein_names_refseq": "transmembrane protein 208 isoform 3", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (mmu:66320)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;27802388;31219806;38381787", "class_list": "", "function": "Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability., [RefSeq, PubMed]; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2H5;Q8R1F8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005773 vacuole", "go_biological_process": "GO:0006914 autophagy;GO:0006624 vacuolar protein processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CR96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXY1-1", "uniprot_id": [ { "id": "TM175_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXY1", "type": "external" } ], "mass": 55578.0, "length": 499, "protein_name": "Endosomal/lysosomal proton channel TMEM175", "gene_name": "Tmem175", "organism": "Mouse", "refseq_name": "endosomal/lysosomal proton channel TMEM175 isoform 1", "refseq_ac": [ { "id": "NP_001157004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157004", "type": "external" } ], "gene_names_uniprotkb": "Tmem175", "gene_names_refseq": "3010001K23Rik; Tmem175; mTMEM175", "protein_names_uniprotkb": "Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; mTMEM175", "protein_names_refseq": "endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; endosomal/lysosomal proton channel TMEM175 isoform 1; endosomal/lysosomal proton channel TMEM175", "tax_id": 10090, "disease": "", "pathway": " (mmu:72392)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19144319;26317472;31219806;33505021;34638858;35750034;35913019;38878670;38960046", "class_list": "", "function": "Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease., [RefSeq, PubMed]; Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease. Review article, [RefSeq, PubMed]; Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Systemic knockout of Tmem175 results in aberrant differentiation but no effect on hematopoietic reconstitution., [RefSeq, PubMed]; TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability., [RefSeq, PubMed]; Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TDC4;Q99K00", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity;GO:0050544 arachidonate binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0035752 lysosomal lumen pH elevation;GO:0090385 phagosome-lysosome fusion;GO:0071805 potassium ion transmembrane transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CXY1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CYC3-1", "uniprot_id": [ { "id": "TM39A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CYC3", "type": "external" } ], "mass": 55720.0, "length": 486, "protein_name": "Transmembrane protein 39A", "gene_name": "Tmem39a", "organism": "Mouse", "refseq_name": "transmembrane protein 39A isoform 1", "refseq_ac": [ { "id": "NP_001192215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192215", "type": "external" } ], "gene_names_uniprotkb": "Tmem39a", "gene_names_refseq": "2610033C09Rik; Tmem39a", "protein_names_uniprotkb": "Transmembrane protein 39A", "protein_names_refseq": "transmembrane protein 39A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67846)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;30084848;31219806", "class_list": "", "function": "Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity). Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TFJ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CYC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CZB3-1", "uniprot_id": [ { "id": "THUM2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CZB3", "type": "external" } ], "mass": 57669.0, "length": 528, "protein_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "gene_name": "Thumpd2", "organism": "Mouse", "refseq_name": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "refseq_ac": [ { "id": "NP_082414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082414", "type": "external" } ], "gene_names_uniprotkb": "Thumpd2", "gene_names_refseq": "2810025A12Rik; Thumpd2", "protein_names_uniprotkb": "U6 snRNA (guanine-N(2))-methyltransferase THUMPD2; 2.1.1.-; THUMP domain-containing protein 2", "protein_names_refseq": "THUMP domain-containing protein 2; U6 snRNA (guanine-N(2))-methyltransferase THUMPD2", "tax_id": 10090, "disease": "", "pathway": " (mmu:72167)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0160230 U6 snRNA (guanine-N(2))-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043527 tRNA methyltransferase complex;GO:0034708 methyltransferase complex", "go_biological_process": "GO:0030488 tRNA methylation;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9CZB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D173-1", "uniprot_id": [ { "id": "TOM7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D173", "type": "external" } ], "mass": 6177.0, "length": 55, "protein_name": "Mitochondrial import receptor subunit TOM7 homolog", "gene_name": "Tomm7", "organism": "Mouse", "refseq_name": "mitochondrial import receptor subunit TOM7 homolog", "refseq_ac": [ { "id": "NP_079670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079670", "type": "external" } ], "gene_names_uniprotkb": "Tomm7", "gene_names_refseq": "1110020J08Rik; Tom7; Tomm7", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM7 homolog; Translocase of outer membrane 7 kDa subunit homolog", "protein_names_refseq": "mitochondrial import receptor subunit TOM7 homolog; translocase of outer membrane 7 kDa subunit homolog; translocase of outer mitochondrial membrane 7 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:66169); (R-MMU-5205685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16075062;30354240;31219806;36299998", "class_list": "", "function": "A hypomorphic variant in the translocase of the outer mitochondrial membrane complex subunit TOMM7 causes short stature and developmental delay. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity)., [UniProtKB, UniProtKB]; Tomm7 drives brain angiogenesis and cerebrovascular network formation through modulating mitochondrial Rac1 signaling within the endothelium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0031647 regulation of protein stability;GO:0030150 protein import into mitochondrial matrix;GO:1905091 positive regulation of type 2 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9D173-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D8D0-1", "uniprot_id": [ { "id": "TR13C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D8D0", "type": "external" } ], "mass": 18798.0, "length": 175, "protein_name": "Tumor necrosis factor receptor superfamily member 13C", "gene_name": "Tnfrsf13c", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 13C isoform 1", "refseq_ac": [ { "id": "NP_082351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082351", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf13c; Baffr; Bcmd; Br3", "gene_names_refseq": "2010006P15Rik; BAFF-R; Baffr; Bcmd-1; Bcmd1; Bcmd; Lvis22; Tnfrsf13c", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 13C; B-cell maturation defect; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3", "protein_names_refseq": "B-cell maturation defect 1; B-cell-activating factor receptor; BAFF receptor; BLyS receptor 3; b cell-activating factor receptor; tumor necrosis factor receptor superfamily member 13C isoform 1", "tax_id": 10090, "disease": "common variable immunodeficiency 4 (Disease Ontology:DOID:0081147)", "pathway": " (mmu:72049); (R-MMU-5668541); (R-MMU-5676594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11509692;11591325;11747827;16075062;21750661;36426969;37751458;38791453", "class_list": "", "function": "B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice., [RefSeq, PubMed]; B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response., [UniProtKB, PubMed]; Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0050776 regulation of immune response;GO:0002636 positive regulation of germinal center formation;GO:0030890 positive regulation of B cell proliferation;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9D8D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCX7-1", "uniprot_id": [ { "id": "TM174_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCX7", "type": "external" } ], "mass": 26449.0, "length": 243, "protein_name": "Transmembrane protein 174", "gene_name": "Tmem174", "organism": "Mouse", "refseq_name": "transmembrane protein 174", "refseq_ac": [ { "id": "NP_080961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080961", "type": "external" } ], "gene_names_uniprotkb": "Tmem174", "gene_names_refseq": "0610009B10Rik; Tmem174", "protein_names_uniprotkb": "Transmembrane protein 174", "protein_names_refseq": "transmembrane protein 174", "tax_id": 10090, "disease": "", "pathway": " (mmu:68344)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "35428804;35459732", "class_list": "", "function": "Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney., [UniProtKB, PubMed, PubMed]; Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification., [RefSeq, PubMed]; Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q96LY0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DCX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQJ0-1", "uniprot_id": [ { "id": "TPC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQJ0", "type": "external" } ], "mass": 94496.0, "length": 817, "protein_name": "Two pore calcium channel protein 1", "gene_name": "Tpcn1", "organism": "Mouse", "refseq_name": "two pore calcium channel protein 1 isoform a", "refseq_ac": [ { "id": "NP_665852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665852", "type": "external" } ], "gene_names_uniprotkb": "Tpcn1; Kiaa1169; Tpc1", "gene_names_refseq": "5730403B01Rik; Tpc1; Tpcn1; mKIAA1169", "protein_names_uniprotkb": "Two pore calcium channel protein 1; Voltage-dependent calcium channel protein TPC1", "protein_names_refseq": "two pore calcium channel protein 1 isoform a; two pore calcium channel protein 1; voltage-dependent calcium channel protein TPC1", "tax_id": 10090, "disease": "", "pathway": " (mmu:252972); (R-MMU-2672351)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12080145;23063126;23394946;24776928;25428506;25722412;28855648;32889694;34428180;36599408", "class_list": "", "function": "Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory., [RefSeq, PubMed]; Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (PubMed:28855648). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (By similarity). Required for mTOR-dependent nutrient sensing (PubMed:23394946)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Two-pore channel protein TPC1 is a determining factor for the adaptation of proximal tubular phosphate handling., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9753, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3V2Z6;Q6ZPW5", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0019905 syntaxin binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0035725 sodium ion transmembrane transport;GO:0075509 endocytosis involved in viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9EQJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER39-1", "uniprot_id": [ { "id": "TOR1A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ER39", "type": "external" } ], "mass": 37830.0, "length": 333, "protein_name": "Torsin-1A", "gene_name": "Tor1a", "organism": "Mouse", "refseq_name": "torsin-1A precursor", "refseq_ac": [ { "id": "NP_659133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659133", "type": "external" } ], "gene_names_uniprotkb": "Tor1a; Dyt1", "gene_names_refseq": "DQ2; Dyt1; Tor1a; torsinA", "protein_names_uniprotkb": "Torsin-1A; 3.6.4.-; Dystonia 1 protein; Torsin ATPase 1; Torsin family 1 member A", "protein_names_refseq": "dystonia 1 protein; torsin ATPase 1; torsin family 1 member A; torsin-1A precursor; torsin-1A", "tax_id": 10090, "disease": "focal dystonia (Disease Ontology:DOID:0050836); torsion dystonia 1 (Disease Ontology:DOID:0060730); arthrogryposis multiplex congenita-5 (Disease Ontology:DOID:0080981); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543)", "pathway": " (mmu:30931); (R-MMU-8856825)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14729251;15767459;16364897;17200151;17428918;18827015;19535332;20015956;20457914;34428180;37321386", "class_list": "", "function": "Cell-specific Dyt1 GAG knock-in to basal ganglia and cerebellum reveal differential effects on motor behavior and sensorimotor network function., [RefSeq, PubMed]; Identifed lamina-associated polypeptide 1 (LAP1) as a torsinA-interacting protein; also identifed a novel transmembrane protein, lumenal domain like LAP1 (LULL1), which also appears to interact with torsinA, [RefSeq, PubMed]; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TorsinA is significantly increased in the brain within hours of treatment with the dopaminergic toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice, suggesting that the TorsinA gene is regulated by cellular stress., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "5.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "7.6.2.16", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.16", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0008092 cytoskeletal protein binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0051584 regulation of dopamine uptake involved in synaptic transmission;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ER39-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN3-1", "uniprot_id": [ { "id": "PGAP6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN3", "type": "external" } ], "mass": 85329.0, "length": 769, "protein_name": "Post-GPI attachment to proteins factor 6", "gene_name": "Pgap6", "organism": "Mouse", "refseq_name": "post-GPI attachment to proteins factor 6 precursor", "refseq_ac": [ { "id": "NP_068565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068565", "type": "external" } ], "gene_names_uniprotkb": "Pgap6; Tmem8a; Tmem8", "gene_names_refseq": "GPI-PLA2; M83; Pgap6; Rxylt1; Tmem8a; Tmem8", "protein_names_uniprotkb": "Post-GPI attachment to proteins factor 6; 3.1.1.4; GPI processing phospholipase A2; GPI-PLA2; M83 protein; Transmembrane protein 8A; Transmembrane protein 8", "protein_names_refseq": "GPI processing phospholipase A2; post-GPI attachment to proteins factor 6 precursor; post-GPI attachment to proteins factor 6; ribitol xylosyltransferase 1; transmembrane protein 6; transmembrane protein 8 (five membrane-spanning domains); transmembrane protein 8A; type I transmembrane protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:60455)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11006113;21750661;25428506;27881714", "class_list": "", "function": "Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP CRIPTO, but not CFC1, at the cell surface. Shedding of CRIPTO modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Also indirectly involved in the translocation of RAC1 from the cytosol to the plasma membrane by maintaining the steady state amount of CAV1-enriched plasma membrane subdomains, stabilizing RAC1 at the plasma membrane., [UniProtKB, UniProtKB]; PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q543X8;Q99JS5", "ec_number_list": [ { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ESN3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM55-1", "uniprot_id": [ { "id": "TOB2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JM55", "type": "external" } ], "mass": 36798.0, "length": 345, "protein_name": "Protein Tob2", "gene_name": "Tob2", "organism": "Mouse", "refseq_name": "protein Tob2", "refseq_ac": [ { "id": "NP_065253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065253", "type": "external" } ], "gene_names_uniprotkb": "Tob2", "gene_names_refseq": "2900090N22Rik; 4930545K18Rik; Tob2; mKIAA1663", "protein_names_uniprotkb": "Protein Tob2; Transducer of erbB-2 2", "protein_names_refseq": "protein Tob2; transducer of erbB-2 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:57259)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10940559;21750661;25428506;27873073;30084848;30779550;32611726;32782141;34428180;36852467;37828378;38165569", "class_list": "", "function": "Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases., [UniProtKB]; TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells., [RefSeq, PubMed]; These results revealed a new molecular mechanism that fine-tunes osteoblast differentiation through miR-5100/Tob2/osterix networks., [RefSeq, PubMed]; Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042809 nuclear vitamin D receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0045671 negative regulation of osteoclast differentiation;GO:0045778 positive regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JM55-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1A9-1", "uniprot_id": [ { "id": "TREX2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1A9", "type": "external" } ], "mass": 25955.0, "length": 236, "protein_name": "Three prime repair exonuclease 2", "gene_name": "Trex2", "organism": "Mouse", "refseq_name": "three prime repair exonuclease 2", "refseq_ac": [ { "id": "NP_036037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036037", "type": "external" } ], "gene_names_uniprotkb": "Trex2", "gene_names_refseq": "Trex2", "protein_names_uniprotkb": "Three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 3.1.11.2", "protein_names_refseq": "3'-5' exonuclease TREX2; three prime repair exonuclease 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:24102)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10391904;19094998;19654293;27365293;28928425;30357414", "class_list": "", "function": "A tumor suppressor role for TREX2 in skin carcinogenesis through which it contributes to keratinocyte apoptosis under conditions of genotoxic stress., [RefSeq, PubMed]; Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair., [UniProtKB, PubMed]; Structural insights into the duplex DNA processing by TREX2 have been reported., [RefSeq, PubMed]; TREX2 acts as a critical factor in the pathogenesis of psoriasis., [RefSeq, PubMed]; This study reports that lack of Trex2 results in the accumulation of DNA fragments in the cytoplasm of cornifying lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes massive accumulation of DNA fragments throughout the cornified layers of the tongue epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Trex2 deletion caused high levels of Robertsonian translocations (RbTs) showing Trex2 is important for chromosomal maintenance., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0060090 molecular adaptor activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006259 DNA metabolic process;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU72-1", "uniprot_id": [ { "id": "TN13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU72", "type": "external" } ], "mass": 34192.0, "length": 309, "protein_name": "Tumor necrosis factor ligand superfamily member 13B", "gene_name": "Tnfsf13b", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 13B isoform 2", "refseq_ac": [ { "id": "NP_001334238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334238", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf13b; Baff", "gene_names_refseq": "BAFF; BLyS; D8Ertd387e; TALL-1; TALL1; THANK; TNFSF20; Tnfsf13b; Tnlg7a; zTNF4", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 13B; B-cell-activating factor; BAFF", "protein_names_refseq": "b cell-activating factor; tumor necrosis factor ligand 7a; tumor necrosis factor ligand superfamily member 13B isoform 2", "tax_id": 10090, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (mmu:24099); (R-MMU-5668541); (R-MMU-5669034); (R-MMU-5676594)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10359578;11862414;12867412;37027297;37751458;38070662;38469292;38791453", "class_list": "", "function": "An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth., [RefSeq, PubMed]; Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection., [RefSeq, PubMed]; Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response., [UniProtKB, PubMed]; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity., [UniProtKB, PubMed]; Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TQ58", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0006955 immune response;GO:0031295 T cell costimulation;GO:0050776 regulation of immune response;GO:0002636 positive regulation of germinal center formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9WU72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VEH0-1", "uniprot_id": [ { "id": "TM144_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VEH0", "type": "external" } ], "mass": 37771.0, "length": 348, "protein_name": "Transmembrane protein 144", "gene_name": "Tmem144", "organism": "Mouse", "refseq_name": "transmembrane protein 144 isoform a", "refseq_ac": [ { "id": "NP_081771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081771", "type": "external" } ], "gene_names_uniprotkb": "Tmem144", "gene_names_refseq": "1110057I03Rik; 5730537D05Rik; Tmem144", "protein_names_uniprotkb": "Transmembrane protein 144", "protein_names_refseq": "transmembrane protein 144 isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:70652)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CYC7", "ec_number_list": [], "go_molecular_function": "GO:0015144 carbohydrate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VEH0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JRP2-1", "uniprot_id": [ { "id": "TM11C_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1JRP2", "type": "external" } ], "mass": 48073.0, "length": 431, "protein_name": "Transmembrane protease serine 11C", "gene_name": "Tmprss11c", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11C", "refseq_ac": [ { "id": "NP_001025468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025468", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11c", "gene_names_refseq": "Tmprss11c; Tmprss13", "protein_names_uniprotkb": "Transmembrane protease serine 11C; 3.4.21.-; Neurobin", "protein_names_refseq": "neurobin; transmembrane protease serine 11C", "tax_id": 10090, "disease": "", "pathway": " (mmu:435845)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18215125;21750661", "class_list": "", "function": "Neurobin is an authentic transmembrane serine protease with trypsin-like activity and is able to process FGF-2 in vitro., [RefSeq, PubMed]; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0097264 self proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1JRP2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UHK8-1", "uniprot_id": [ { "id": "TNR6A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UHK8", "type": "external" } ], "mass": 203150.0, "length": 1896, "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "Tnrc6a", "organism": "Mouse", "refseq_name": "trinucleotide repeat-containing gene 6A protein", "refseq_ac": [ { "id": "NP_659174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659174", "type": "external" } ], "gene_names_uniprotkb": "Tnrc6a; Kiaa1460", "gene_names_refseq": "2010321I05Rik; 3110054G10Rik; CAGH26; D130023A07Rik; GW182; Tnrc6a; Tnrc6", "protein_names_uniprotkb": "Trinucleotide repeat-containing gene 6A protein", "protein_names_refseq": "GW182 autoantigen; trinucleotide repeat-containing gene 6A protein", "tax_id": 10090, "disease": "familial adult myoclonic epilepsy 6 (Disease Ontology:DOID:0111696)", "pathway": " (mmu:233833); (R-MMU-426496); (R-MMU-5578749)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "21606357;21750661;22187428;22517741;29237092;30059200;31219806;32782141;32848054;34428180;34678516;35822049;36852467;40021952;40885482", "class_list": "", "function": "Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:22187428). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:22187428). As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "F6ZMJ4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0009267 cellular response to starvation;GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "Q3UHK8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UWZ0-1", "uniprot_id": [ { "id": "TRI75_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UWZ0", "type": "external" } ], "mass": 53385.0, "length": 467, "protein_name": "Tripartite motif-containing protein 75", "gene_name": "Trim75", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 75", "refseq_ac": [ { "id": "NP_001028601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028601", "type": "external" } ], "gene_names_uniprotkb": "Trim75; Gm794", "gene_names_refseq": "Gm794; Trim75", "protein_names_uniprotkb": "Tripartite motif-containing protein 75", "protein_names_refseq": "tripartite motif-containing protein 75", "tax_id": 10090, "disease": "", "pathway": " (mmu:333307)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;26974323;38643284", "class_list": "", "function": "Maternal factor Trim75 contributes to zygotic genome activation program in mouse early embryos. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in female meiosis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0007144 female meiosis I;GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3UWZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U284-1", "uniprot_id": [ { "id": "TM231_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U284", "type": "external" } ], "mass": 36261.0, "length": 315, "protein_name": "Transmembrane protein 231", "gene_name": "Tmem231", "organism": "Mouse", "refseq_name": "transmembrane protein 231 isoform 1", "refseq_ac": [ { "id": "NP_001028493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028493", "type": "external" } ], "gene_names_uniprotkb": "Tmem231", "gene_names_refseq": "4932417I16Rik; Gm178; Tmem231", "protein_names_uniprotkb": "Transmembrane protein 231", "protein_names_refseq": "transmembrane protein 231 isoform 1", "tax_id": 10090, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); Joubert syndrome 20 (Disease Ontology:DOID:0110989); orofaciodigital syndrome (Disease Ontology:DOID:4501)", "pathway": " (mmu:234740)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22179047;25428506;25605945;34428180", "class_list": "", "function": "Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q497S7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0060170 ciliary membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0060563 neuroepithelial cell differentiation;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3U284-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TYE7-1", "uniprot_id": [ { "id": "TLCD5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TYE7", "type": "external" } ], "mass": 27705.0, "length": 245, "protein_name": "TLC domain-containing protein 5", "gene_name": "Tlcd5", "organism": "Mouse", "refseq_name": "TLC domain-containing protein 5", "refseq_ac": [ { "id": "NP_001030035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030035", "type": "external" } ], "gene_names_uniprotkb": "Tlcd5; Gm184; Tmem136", "gene_names_refseq": "Gm184; Tlcd5; Tmem136", "protein_names_uniprotkb": "TLC domain-containing protein 5; Transmembrane protein 136", "protein_names_refseq": "TLC domain-containing protein 5; transmembrane protein 136", "tax_id": 10090, "disease": "", "pathway": " (mmu:235300)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B9EI43", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3TYE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BYU6-1", "uniprot_id": [ { "id": "TOIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BYU6", "type": "external" } ], "mass": 54496.0, "length": 502, "protein_name": "Torsin-1A-interacting protein 2", "gene_name": "Tor1aip2", "organism": "Mouse", "refseq_name": "torsin-1A-interacting protein 2 isoform b", "refseq_ac": [ { "id": "NP_766431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766431", "type": "external" } ], "gene_names_uniprotkb": "Tor1aip2; Ifrg15; Lull1", "gene_names_refseq": "1110020D10Rik; 15kDa; A130072J07; Ifrg15; Lull1; Tor1aip2", "protein_names_uniprotkb": "Torsin-1A-interacting protein 2", "protein_names_refseq": "15 kDa interferon-responsive protein; interferon alpha responsive gene, 15 kDa; interferon alpha responsive protein (15 kDa); lumenal domain like LAP1; torsin-1A-interacting protein 2 isoform b; torsin-1A-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:240832)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10.1101/2023.09.13.557529;15767459;16364897;19349973;20457914;21750661;22871540;26092934;26495903;26911731;28135057;30084848;30779550;30899004;34428180;36852467", "class_list": "", "function": "Identifed a novel transmembrane protein, lumenal domain like LAP1 (LULL1), which appears to interact with torsinA; it resides in the main endoplasmic reticulum., [RefSeq, PubMed]; Ifrg15 transcription might be either potentially regulated or dependent on the post-transcriptional effects of IFN-alpha mediated by the three genes Oct4, c-Myc and Nanog indirectly, [RefSeq, PubMed]; Preimplantation embryo development was arrested at the 1-cell stage after knocking down Ifrg15 expression., [RefSeq, PubMed]; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity)., [UniProtKB]; The data suggest that LULL1 oligomerizes to engage and transiently disassemble torsinA oligomers, and is thereby positioned to transduce cytoplasmic signals to the inner nuclear membrane through torsinA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6NY10;Q8BJP0", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0061024 membrane organization;GO:0032781 positive regulation of ATP-dependent activity;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q8BYU6-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13412-1", "uniprot_id": [ { "id": "TNNI2_MOUSE", "url": "https://www.uniprot.org/uniprot/P13412", "type": "external" } ], "mass": 21358.0, "length": 182, "protein_name": "Troponin I, fast skeletal muscle", "gene_name": "Tnni2", "organism": "Mouse", "refseq_name": "troponin I, fast skeletal muscle", "refseq_ac": [ { "id": "NP_033431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033431", "type": "external" } ], "gene_names_uniprotkb": "Tnni2", "gene_names_refseq": "Tnni2", "protein_names_uniprotkb": "Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform", "protein_names_refseq": "troponin I, fast skeletal muscle", "tax_id": 10090, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); distal arthrogryposis type 2B1 (Disease Ontology:DOID:0111600); heart disease (Disease Ontology:DOID:114); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (mmu:21953); (R-MMU-390522)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21750661;2760067;39927985", "class_list": "", "function": "Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A6J9", "ec_number_list": [], "go_molecular_function": "GO:0031014 troponin T binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0045893 positive regulation of DNA-templated transcription;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13412-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TB48-1", "uniprot_id": [ { "id": "S38AC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TB48", "type": "external" } ], "mass": 55838.0, "length": 496, "protein_name": "Putative sodium-coupled neutral amino acid transporter 12", "gene_name": "SLC38A12; Tmem104", "organism": "Mouse", "refseq_name": "putative sodium-coupled neutral amino acid transporter 12", "refseq_ac": [ { "id": "NP_001028565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028565", "type": "external" } ], "gene_names_uniprotkb": "SLC38A12; Tmem104; Tmem104", "gene_names_refseq": "C630005D06Rik; Slc38a12; Tmem104; mFLJ00021", "protein_names_uniprotkb": "Putative sodium-coupled neutral amino acid transporter 12; Solute carrier family 38 member 12; Transmembrane protein 104", "protein_names_refseq": "putative sodium-coupled neutral amino acid transporter 12; transmembrane protein 104", "tax_id": 10090, "disease": "", "pathway": " (mmu:320534)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U2Y2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3TB48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20334-1", "uniprot_id": [ { "id": "TNR9_MOUSE", "url": "https://www.uniprot.org/uniprot/P20334", "type": "external" } ], "mass": 27598.0, "length": 256, "protein_name": "Tumor necrosis factor receptor superfamily member 9", "gene_name": "Tnfrsf9", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 9 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001070977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070977", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf9; Cd137; Ila; Ly63", "gene_names_refseq": "4-1BB; A930040I11Rik; CDw137; Cd137; ILA; Ly63; Tnfrsf9", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB", "protein_names_refseq": "4-1BB ligand receptor; CD137 antigen; T-cell antigen 4-1BB; secreted CD137 antigen; tumor necrosis factor receptor superfamily member 9 isoform 1 precursor", "tax_id": 10090, "disease": "immunodeficiency 109 (Disease Ontology:DOID:0061078)", "pathway": " (mmu:21942); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;2784565;36544785;7678621;8133039", "class_list": "", "function": "Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (By similarity)., [UniProtKB, UniProtKB]; Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P20334-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2AJB2-1", "uniprot_id": [ { "id": "TM141_MOUSE", "url": "https://www.uniprot.org/uniprot/A2AJB2", "type": "external" } ], "mass": 11893.0, "length": 108, "protein_name": "Transmembrane protein 141", "gene_name": "Tmem141", "organism": "Mouse", "refseq_name": "transmembrane protein 141 isoform 1", "refseq_ac": [ { "id": "NP_001035219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035219", "type": "external" } ], "gene_names_uniprotkb": "Tmem141; D2Ertd217e", "gene_names_refseq": "1110065P14Rik; D2Ertd217e; Tmem141", "protein_names_uniprotkb": "Transmembrane protein 141", "protein_names_refseq": "transmembrane protein 141 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:51875)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2AJB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RXC1-1", "uniprot_id": [ { "id": "TPC11_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RXC1", "type": "external" } ], "mass": 128396.0, "length": 1133, "protein_name": "Trafficking protein particle complex subunit 11", "gene_name": "Trappc11", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 11", "refseq_ac": [ { "id": "NP_796214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796214", "type": "external" } ], "gene_names_uniprotkb": "Trappc11", "gene_names_refseq": "D030016E14Rik; Trappc11", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 11", "protein_names_refseq": "trafficking protein particle complex subunit 11", "tax_id": 10090, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2S (Disease Ontology:DOID:0110287); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (mmu:320714); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "22872234;25605945;34428180;34887587", "class_list": "", "function": "Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EJS1;Q52KP8;Q8BXY8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030008 TRAPP complex", "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:0007030 Golgi organization;GO:0061635 regulation of protein complex stability", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2RXC1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56983-1", "uniprot_id": [ { "id": "TM14A_MOUSE", "url": "https://www.uniprot.org/uniprot/P56983", "type": "external" } ], "mass": 10594.0, "length": 99, "protein_name": "Transmembrane protein 14A", "gene_name": "Tmem14a", "organism": "Mouse", "refseq_name": "transmembrane protein 14A isoform 1", "refseq_ac": [ { "id": "NP_001277608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277608", "type": "external" } ], "gene_names_uniprotkb": "Tmem14a", "gene_names_refseq": "5730496E24Rik; PTD011; Tmem14a", "protein_names_uniprotkb": "Transmembrane protein 14A", "protein_names_refseq": "transmembrane protein 14A isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:75712)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZZ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56983-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG75-1", "uniprot_id": [ { "id": "TM198_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG75", "type": "external" } ], "mass": 39752.0, "length": 360, "protein_name": "Transmembrane protein 198", "gene_name": "Tmem198", "organism": "Mouse", "refseq_name": "transmembrane protein 198 isoform 2", "refseq_ac": [ { "id": "NP_796030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796030", "type": "external" } ], "gene_names_uniprotkb": "Tmem198", "gene_names_refseq": "A230078I05Rik; Tmem198-1; Tmem198a; Tmem198", "protein_names_uniprotkb": "Transmembrane protein 198", "protein_names_refseq": "transmembrane protein 198 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:319998)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30779550", "class_list": "", "function": "Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016020 membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BG75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43345-1", "uniprot_id": [ { "id": "TLX1_MOUSE", "url": "https://www.uniprot.org/uniprot/P43345", "type": "external" } ], "mass": 34644.0, "length": 332, "protein_name": "T-cell leukemia homeobox protein 1", "gene_name": "Tlx1", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tlx1; Hox11; Tlx-1", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell leukemia homeobox protein 1; Homeobox TLX-1; Homeobox protein Hox-11", "protein_names_refseq": "", "tax_id": 10090, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523)", "pathway": " (mmu:21908)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "20485683;21750661;35820727;7596820;7908720;7908826", "class_list": "", "function": "Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P43345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55144-1", "uniprot_id": [ { "id": "TLX3_MOUSE", "url": "https://www.uniprot.org/uniprot/O55144", "type": "external" } ], "mass": 31837.0, "length": 291, "protein_name": "T-cell leukemia homeobox protein 3", "gene_name": "Tlx3", "organism": "Mouse", "refseq_name": "T-cell leukemia homeobox protein 3", "refseq_ac": [ { "id": "NP_064300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064300", "type": "external" } ], "gene_names_uniprotkb": "Tlx3; Hox11l2; Rnx; Tlx1l2", "gene_names_refseq": "Hox11l2; Rnx; Tlx1l2; Tlx3", "protein_names_uniprotkb": "T-cell leukemia homeobox protein 3; Homeobox TLX-3; Homeobox protein Hox-11L2; Respiratory neuron homeobox protein", "protein_names_refseq": "T-cell leukemia homeobox protein 3; homeo box 11-like 2; homeobox TLX-3; homeobox protein Hox-11L2; respiratory neuron homeobox protein", "tax_id": 10090, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (mmu:27140)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25428506", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5SQB4", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001708 cell fate specification;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045665 negative regulation of neuron differentiation;GO:0001764 neuron migration;GO:0002087 regulation of respiratory gaseous exchange by nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O55144-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70274-1", "uniprot_id": [ { "id": "TP4A2_MOUSE", "url": "https://www.uniprot.org/uniprot/O70274", "type": "external" } ], "mass": 19127.0, "length": 167, "protein_name": "Protein tyrosine phosphatase type IVA 2", "gene_name": "Ptp4a2", "organism": "Mouse", "refseq_name": "protein tyrosine phosphatase type IVA 2 isoform 1", "refseq_ac": [ { "id": "NP_001158217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158217", "type": "external" } ], "gene_names_uniprotkb": "Ptp4a2; Prl2", "gene_names_refseq": "Prl-2; Ptp4a2", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 2; 3.1.3.48; PRL-2; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2", "protein_names_refseq": "protein tyrosine phosphatase type IVA 2 isoform 1; protein tyrosine phosphatase type IVA 2; protein-tyrosine phosphatase of regenerating liver 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:19244); (R-MMU-8873719)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10747914;34428180;36210013;37756563;37869777;38286811;9514946", "class_list": "", "function": "Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke., [RefSeq, PubMed]; PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation., [RefSeq, PubMed]; PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U1K7", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70274-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88472-1", "uniprot_id": [ { "id": "TNR17_MOUSE", "url": "https://www.uniprot.org/uniprot/O88472", "type": "external" } ], "mass": 20442.0, "length": 185, "protein_name": "Tumor necrosis factor receptor superfamily member 17", "gene_name": "Tnfrsf17", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 17", "refseq_ac": [ { "id": "NP_035738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035738", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf17; Bcma; Bcm", "gene_names_refseq": "BCMA; BCM; Tnfrsf13a; Tnfrsf13; Tnfrsf17", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein", "protein_names_refseq": "B-cell maturation protein; tumor necrosis factor receptor superfamily member 17", "tax_id": 10090, "disease": "colon carcinoma (Disease Ontology:DOID:1520); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:21935); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14707116;37828378;9846698", "class_list": "", "function": "A vital role of BCMA in bone marrow plasma cell survival., [RefSeq, PubMed]; Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0002250 adaptive immune response;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88472-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11214-1", "uniprot_id": [ { "id": "TPA_MOUSE", "url": "https://www.uniprot.org/uniprot/P11214", "type": "external" } ], "mass": 63097.0, "length": 559, "protein_name": "Tissue-type plasminogen activator", "gene_name": "Plat", "organism": "Mouse", "refseq_name": "tissue-type plasminogen activator preproprotein", "refseq_ac": [ { "id": "NP_032898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032898", "type": "external" } ], "gene_names_uniprotkb": "Plat", "gene_names_refseq": "D8Ertd2e; Plat; tPA", "protein_names_uniprotkb": "Tissue-type plasminogen activator; 3.4.21.68; t-PA; t-plasminogen activator; tPA", "protein_names_refseq": "t-plasminogen activator; tissue-type plasminogen activator preproprotein", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); osteonecrosis (Disease Ontology:DOID:10159); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); factor VIII deficiency (Disease Ontology:DOID:12134); blood coagulation disease (Disease Ontology:DOID:1247); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); severe acute respiratory syndrome (Disease Ontology:DOID:2945); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); leukopenia (Disease Ontology:DOID:615); peritonitis (Disease Ontology:DOID:8283); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:18791); (R-MMU-186797); (R-MMU-75205)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;2826484;38609369;7523120", "class_list": "", "function": "Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)., [UniProtKB, UniProtKB]; The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7U0;Q91VP2", "ec_number_list": [ { "id": "3.4.21.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.68", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0014909 smooth muscle cell migration;GO:0035249 synaptic transmission, glutamatergic;GO:0010757 negative regulation of plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P11214-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41274-1", "uniprot_id": [ { "id": "TNFL9_MOUSE", "url": "https://www.uniprot.org/uniprot/P41274", "type": "external" } ], "mass": 33853.0, "length": 309, "protein_name": "Tumor necrosis factor ligand superfamily member 9", "gene_name": "Tnfsf9", "organism": "Mouse", "refseq_name": "tumor necrosis factor ligand superfamily member 9", "refseq_ac": [ { "id": "NP_033430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033430", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf9; Cd137l; Cd157l; Ly63l", "gene_names_refseq": "4-1BB-L; 4-1BBL; Cd137l; Ly63l; Tnfsf9", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL", "protein_names_refseq": "4-1BB ligand; tumor necrosis factor ligand superfamily member 9", "tax_id": 10090, "disease": "multiple sclerosis (Disease Ontology:DOID:2377); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:21950); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "34428180;35763154;35859732;37796401;38344886;8405064", "class_list": "", "function": "CD137-CD137L Aggravates Calcification of Vascular Smooth Muscle Cell and Vasculature of ApoE[-/-] Mice Via Rab7-Mediated Autophagy., [RefSeq, PubMed]; CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy., [RefSeq, PubMed]; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages., [UniProtKB]; Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke., [RefSeq, PubMed]; Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0042127 regulation of cell population proliferation;GO:0032755 positive regulation of interleukin-6 production;GO:0032729 positive regulation of type II interferon production;GO:0042104 positive regulation of activated T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P41274-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86045-1", "uniprot_id": [ { "id": "TM207_MOUSE", "url": "https://www.uniprot.org/uniprot/P86045", "type": "external" } ], "mass": 15808.0, "length": 143, "protein_name": "Transmembrane protein 207", "gene_name": "Tmem207", "organism": "Mouse", "refseq_name": "transmembrane protein 207 precursor", "refseq_ac": [ { "id": "NP_001095110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095110", "type": "external" } ], "gene_names_uniprotkb": "Tmem207", "gene_names_refseq": "100043057; Gm540; Tmem207", "protein_names_uniprotkb": "Transmembrane protein 207", "protein_names_refseq": "transmembrane protein 207 precursor", "tax_id": 10090, "disease": "epidermal appendage tumor (Disease Ontology:DOID:2433)", "pathway": " (mmu:100043057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031901 early endosome membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P86045-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TIR1-1", "uniprot_id": [ { "id": "TPC13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TIR1", "type": "external" } ], "mass": 46477.0, "length": 417, "protein_name": "Trafficking protein particle complex subunit 13", "gene_name": "Trappc13", "organism": "Mouse", "refseq_name": "trafficking protein particle complex subunit 13 isoform 2", "refseq_ac": [ { "id": "NP_001087228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001087228", "type": "external" } ], "gene_names_uniprotkb": "Trappc13; 2410002O22Rik", "gene_names_refseq": "2410002O22Rik; 2610524F24Rik; Trappc13", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 13", "protein_names_refseq": "UPF0533 protein C5orf44 homolog; trafficking protein particle complex subunit 13 isoform 2; trafficking protein particle complex subunit 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:66975); (R-MMU-8876198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;30084848", "class_list": "", "function": "Component of the multisubunit TRAPP (transport protein particle) III complex (By similarity). As a component of TRAPPIII complex, participates in the activation of RAB1 and RAB43, but not RAB11A, RAB11B, nor RAB19 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9781, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQS3;Q3UE00;Q8BN93;Q8VDJ6;Q9CWW3;Q9CXV2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990072 TRAPPIII protein complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006901 vesicle coating;GO:0099022 vesicle tethering", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3TIR1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UQ41-1", "uniprot_id": [ { "id": "TM11A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UQ41", "type": "external" } ], "mass": 43605.0, "length": 389, "protein_name": "Transmembrane protease serine 11A", "gene_name": "Tmprss11a", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11A", "refseq_ac": [ { "id": "NP_001028405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028405", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11a; Desc3; Gm7; Hatl1", "gene_names_refseq": "Gm7; Tmprss11a", "protein_names_uniprotkb": "Transmembrane protease serine 11A; 3.4.21.-; Airway trypsin-like protease 1; DESC-3; Serine protease DESC3", "protein_names_refseq": "DESC-3; airway trypsin-like protease 1; serine protease DESC3; transmembrane protease serine 11A", "tax_id": 10090, "disease": "", "pathway": " (mmu:194597)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15328353;16380648;21853097;29976755", "class_list": "", "function": "A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed., [RefSeq, PubMed]; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest., [UniProtKB]; Show that TMPRSS11A, another member of the TTSP family, cleaves and activates the influenza A virus (FLUAV) HA and the Middle East respiratory syndrome coronavirus spike protein (MERS-S)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3UQ41-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78IS1-1", "uniprot_id": [ { "id": "TMED3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q78IS1", "type": "external" } ], "mass": 25465.0, "length": 221, "protein_name": "Transmembrane emp24 domain-containing protein 3", "gene_name": "Tmed3", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_079636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079636", "type": "external" } ], "gene_names_uniprotkb": "Tmed3", "gene_names_refseq": "1200002G13Rik; P24b; Tmed3", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 3; p24 family protein gamma-4; p24gamma4", "protein_names_refseq": "integral type I protein; p24 family protein gamma-4; p24gamma4; transmembrane emp24 domain containing 3; transmembrane emp24 domain-containing protein 3 precursor; transmembrane emp24 domain-containing protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:66111); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22872234;28315936;30084848;31219806;34203471;34428180;35358714", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity)., [UniProtKB]; Trafficking protein TMED3 promotes esophageal squamous cell carcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9DC62;Q9DCK9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q78IS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1A5-1", "uniprot_id": [ { "id": "TM41B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K1A5", "type": "external" } ], "mass": 32429.0, "length": 291, "protein_name": "Transmembrane protein 41B", "gene_name": "Tmem41b", "organism": "Mouse", "refseq_name": "transmembrane protein 41B", "refseq_ac": [ { "id": "NP_705745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705745", "type": "external" } ], "gene_names_uniprotkb": "Tmem41b; D7Ertd743e; Kiaa0033", "gene_names_refseq": "1500015G02Rik; 1500031M19Rik; D7Ertd70e; D7Ertd743e; Tmem41b", "protein_names_uniprotkb": "Transmembrane protein 41B; Protein stasimon", "protein_names_refseq": "Stasimon; protein stasimon; transmembrane protein 41B", "tax_id": 10090, "disease": "", "pathway": " (mmu:233724)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "21750661;23063131;25428506;30084848;30352685;31219806;31851921;34015269;34428180;34871328;37828378;38640735", "class_list": "", "function": "Defective U12 splicing and reduced mRNA levels of Stasimon (NP_705745) was observed in the motor circuit neurons of mice with spinal muscular atrophy., [RefSeq, PubMed]; Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication. Publication Status: Online-Only, [RefSeq, PubMed]; Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy., [RefSeq, PubMed]; Stasimon is an essential gene for mouse embryonic development., [RefSeq, PubMed]; Stasimon/Tmem41b is required for cell proliferation and adult mouse survival., [RefSeq, PubMed]; TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKT0;Q3TLK6;Q8C1X2;Q8CBS5;Q8CBU5", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0016020 membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0007399 nervous system development;GO:0044830 host-mediated perturbation of viral RNA genome replication;GO:0032365 intracellular lipid transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K1A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2Q0-1", "uniprot_id": [ { "id": "TRI29_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R2Q0", "type": "external" } ], "mass": 65820.0, "length": 587, "protein_name": "Tripartite motif-containing protein 29", "gene_name": "Trim29", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 29", "refseq_ac": [ { "id": "NP_076144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076144", "type": "external" } ], "gene_names_uniprotkb": "Trim29", "gene_names_refseq": "1110047J21Rik; 2810431N19Rik; 4732461M22Rik; Trim29", "protein_names_uniprotkb": "Tripartite motif-containing protein 29", "protein_names_refseq": "tripartite motif protein 29; tripartite motif-containing protein 29", "tax_id": 10090, "disease": "", "pathway": " (mmu:72169)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11331580;20368352;20947501;21183079;25593307;27695001;30084848;34428180;36210013;36841942;37021569;38664417", "class_list": "", "function": "ATDC increases cell proliferation via inhibition of p53 nuclear activities., [RefSeq, PubMed]; ATDC up-regulates CD44 in mouse and human PanIN lesions via activation of beta-catenin signaling, leading to the induction of an epithelial-to-mesenchymal transition (EMT) phenotype characterized by expression of Zeb1 and Snail1., [RefSeq, PubMed]; Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein, [RefSeq, PubMed]; Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation., [UniProtKB, UniProtKB]; TRIM29 (Tripartite Motif Containing 29) Alleviates NLRC4 (NLR Family CARD Domain Containing Protein 4) Inflammasome Related Cerebral Injury via Promoting Proteasomal Degradation of NLRC4 in Ischemic Stroke., [RefSeq, PubMed]; TRIM29 promotes podocyte pyroptosis in diabetic nephropathy through the NF-kB/NLRP3 inflammasome pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CEE2;Q922Y3;Q99PN5;Q9CSC9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045087 innate immune response;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8R2Q0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08712-1", "uniprot_id": [ { "id": "TR11B_MOUSE", "url": "https://www.uniprot.org/uniprot/O08712", "type": "external" } ], "mass": 45923.0, "length": 401, "protein_name": "Tumor necrosis factor receptor superfamily member 11B", "gene_name": "Tnfrsf11b", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 11B isoform 1 precursor", "refseq_ac": [ { "id": "NP_032790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032790", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf11b; Ocif; Opg", "gene_names_refseq": "OCIF; Opg; TR1; Tnfrsf11b", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin", "protein_names_refseq": "osteoclastogenesis inhibitory factor; osteoprotegerin; tumor necrosis factor receptor superfamily member 11B isoform 1 precursor; tumor necrosis factor receptor superfamily member 11B", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); lupus nephritis (Disease Ontology:DOID:0080162); Paget's disease of bone 5 (Disease Ontology:DOID:0081368); hereditary arterial and articular multiple calcification syndrome (Disease Ontology:DOID:0111582); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); secondary hyperparathyroidism (Disease Ontology:DOID:12466); aortic valve stenosis (Disease Ontology:DOID:1712); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); peripheral vascular disease (Disease Ontology:DOID:341); cerebral infarction (Disease Ontology:DOID:3526); coronary stenosis (Disease Ontology:DOID:4248); Paget's disease of bone (Disease Ontology:DOID:5408); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (mmu:18383); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;10952716;23039992;38928140;9108485;9714833", "class_list": "", "function": "Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis., [UniProtKB, PubMed]; Osteoprotegerin Is Essential for the Development of Endothelial Dysfunction Induced by Angiotensin II in Mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 26, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70202", "ec_number_list": [], "go_molecular_function": "GO:1904399 heparan sulfate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043235 receptor complex", "go_biological_process": "GO:0042489 negative regulation of odontogenesis of dentin-containing tooth;GO:0007165 signal transduction;GO:0030198 extracellular matrix organization;GO:0006915 apoptotic process;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O08712-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A9T0-1", "uniprot_id": [ { "id": "TBKB1_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A9T0", "type": "external" } ], "mass": 67001.0, "length": 611, "protein_name": "TANK-binding kinase 1-binding protein 1", "gene_name": "Tbkbp1", "organism": "Mouse", "refseq_name": "TANK-binding kinase 1-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_932768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932768", "type": "external" } ], "gene_names_uniprotkb": "Tbkbp1; Sintbad", "gene_names_refseq": "3110043L15Rik; ProSAPiP2; SINTBAD; Tbkbp1", "protein_names_uniprotkb": "TANK-binding kinase 1-binding protein 1; Similar to NAP1 TBK1 adapter; TBK1-binding protein 1", "protein_names_refseq": "TANK-binding kinase 1-binding protein 1 isoform 1; TANK-binding kinase 1-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:73174)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17568778;21183079;21750661;30022064", "class_list": "", "function": "Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus., [UniProtKB, PubMed]; Results suggest that efficient signal transduction upon viral infection requires SINTBAD, TANK and NAP1 because they link TBK1 and IKKi to virus-activated signalling cascades, [RefSeq, PubMed]; SINTBAD regulates IL-15-induced autophagy and NKT cell survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A9S9;Q6PFF1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2A9T0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47741-1", "uniprot_id": [ { "id": "TNR4_MOUSE", "url": "https://www.uniprot.org/uniprot/P47741", "type": "external" } ], "mass": 30154.0, "length": 272, "protein_name": "Tumor necrosis factor receptor superfamily member 4", "gene_name": "Tnfrsf4", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 4 precursor", "refseq_ac": [ { "id": "NP_035789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035789", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf4; Ox40; Txgp1", "gene_names_refseq": "ACT35; CD134; Ly-70; Ox40; TXGP1L; Tnfrsf4; Txgp1", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 4; OX40 antigen; OX40L receptor", "protein_names_refseq": "OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1; tumor necrosis factor receptor superfamily member 4 precursor", "tax_id": 10090, "disease": "immunodeficiency 16 (Disease Ontology:DOID:0111935); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)", "pathway": " (mmu:22163); (R-MMU-5669034)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;29244194;35820727;37211291;37932534;7737295;8228223", "class_list": "", "function": "Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity)., [UniProtKB]; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity., [UniProtKB, UniProtKB]; T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation., [RefSeq, PubMed]; The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0006968 cellular defense response;GO:0030890 positive regulation of B cell proliferation;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P47741-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61087-1", "uniprot_id": [ { "id": "UBE2K_MOUSE", "url": "https://www.uniprot.org/uniprot/P61087", "type": "external" } ], "mass": 22407.0, "length": 200, "protein_name": "Ubiquitin-conjugating enzyme E2 K", "gene_name": "Ube2k", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 K isoform 1", "refseq_ac": [ { "id": "NP_058066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058066", "type": "external" } ], "gene_names_uniprotkb": "Ube2k; Hip2", "gene_names_refseq": "D5Ertd601e; E2-25k; HIP-2; Hip2; Hypg; Lig; Ube2k", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 K; 2.3.2.23; E2 ubiquitin-conjugating enzyme K; HIP-2; Huntingtin-interacting protein 2; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-conjugating enzyme E2-25K; Ubiquitin-protein ligase", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme K; huntingtin interacting protein 2; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2 K isoform 1; ubiquitin-conjugating enzyme E2-25 kDa; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); ubiquitin-protein ligase", "tax_id": 10090, "disease": "", "pathway": " (mmu:53323); (R-MMU-8866652); (R-MMU-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10585161;18710920;21750661;26740625;28032866;30084848;30282965;34428180;35216141;36896783;37507081", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. Involved in stabilization of CASP12 during ER stress-mediated amyloid-beta neurotoxicity probably by inhibiting proteasome activity; in vitro ubiquitinates CASP12., [UniProtKB, PubMed]; E2-25K has a crucial role in oxidative stress and cerebral Ischemia/Reperfusion-induced damage through inhibiting proteasome via its SUMOylation. Publication Status: Online-Only, [RefSeq, PubMed]; E2-25K/Hip-2 is thus an essential upstream regulator of the expression and activation of caspase-12 in endoplasmic reticulum stress-mediated Abeta neurotoxicity., [RefSeq, PubMed]; HIP2 insufficiency as a contributing factor for PD. Publication Status: Online-Only, [RefSeq, PubMed]; Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. Publication Status: Online-Only, [RefSeq, PubMed]; UBE2K regulated by IGF2BP3 promotes cell proliferation and stemness in pancreatic ductal adenocarcinoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54806;P27924;Q16721;Q9CVV9", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032433 filopodium tip", "go_biological_process": "GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0060337 type I interferon-mediated signaling pathway;GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P61087-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W67-1", "uniprot_id": [ { "id": "UBL7_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W67", "type": "external" } ], "mass": 40433.0, "length": 380, "protein_name": "Ubiquitin-like protein 7", "gene_name": "Ubl7", "organism": "Mouse", "refseq_name": "ubiquitin-like protein 7 isoform 1", "refseq_ac": [ { "id": "NP_001116345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116345", "type": "external" } ], "gene_names_uniprotkb": "Ubl7", "gene_names_refseq": "2300004C15Rik; Ubl7", "protein_names_uniprotkb": "Ubiquitin-like protein 7", "protein_names_refseq": "ubiquitin-like protein 7 isoform 1; ubiquitin-like protein 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:69459)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;21750661;34428180", "class_list": "", "function": "Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "E9Q1S0;Q9D7P5", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0044314 protein K27-linked ubiquitination;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91W67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PL6-1", "uniprot_id": [ { "id": "UBXN6_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PL6", "type": "external" } ], "mass": 49796.0, "length": 442, "protein_name": "UBX domain-containing protein 6", "gene_name": "Ubxn6", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 6 isoform 1", "refseq_ac": [ { "id": "NP_077752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077752", "type": "external" } ], "gene_names_uniprotkb": "Ubxn6; Ubxd1; Ubxdc2", "gene_names_refseq": "1200008L11Rik; 2210415J11Rik; Ubxd1; Ubxdc2; Ubxn6", "protein_names_uniprotkb": "UBX domain-containing protein 6; UBX domain-containing protein 1", "protein_names_refseq": "UBX domain-containing protein 1; UBX domain-containing protein 6 isoform 1; UBX domain-containing protein 6", "tax_id": 10090, "disease": "", "pathway": " (mmu:66530)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11342112;18656546;21183079;21750661;26740625;27913212", "class_list": "", "function": "May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes., [UniProtKB, UniProtKB]; These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJA5;Q3TTP1;Q3UG19;Q8C4D6;Q91W79;Q9D7L9", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0043335 protein unfolding;GO:0016236 macroautophagy;GO:0036503 ERAD pathway;GO:0000423 mitophagy;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99PL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70406-1", "uniprot_id": [ { "id": "UCP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P70406", "type": "external" } ], "mass": 33374.0, "length": 309, "protein_name": "Dicarboxylate carrier UCP2", "gene_name": "Ucp2", "organism": "Mouse", "refseq_name": "dicarboxylate carrier UCP2", "refseq_ac": [ { "id": "NP_035801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035801", "type": "external" } ], "gene_names_uniprotkb": "Ucp2; Slc25a8", "gene_names_refseq": "Slc25a8; UCP 2; UCPH; Ucp2", "protein_names_uniprotkb": "Dicarboxylate carrier UCP2; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH", "protein_names_refseq": "dicarboxylate carrier SLC25A8; dicarboxylate carrier UCP2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2, mitochondrial", "tax_id": 10090, "disease": "polycystic liver disease (Disease Ontology:DOID:0050770); stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); carotid artery disease (Disease Ontology:DOID:3407); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22228); (R-MMU-167826)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11101840;11756659;12011051;21750661;21785437;25127353;26919426;33798544;34644537;38254621;38615660;39159561;9133562;9710252", "class_list": "", "function": "Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle lowering the ATP/ADP ratio and reactive oxygen species (ROS) production (By similarity). May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides (By similarity) (PubMed:11101840, PubMed:11756659, PubMed:12011051, PubMed:21785437, PubMed:25127353). Regulates the use of glucose as a source of energy. Required for glucose-induced DRP1-dependent mitochondrial fission and neuron activation in the ventromedial nucleus of the hypothalamus (VMH). This mitochondrial adaptation mechanism modulates the VMH pool of glucose-excited neurons with an impact on systemic glucose homeostasis (PubMed:26919426). Regulates ROS levels and metabolic reprogramming of macrophages during the resolution phase of inflammation. Attenuates ROS production in response to IL33 to preserve the integrity of the Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). Can unidirectionally transport anions including L-malate, L-aspartate, phosphate and chloride ions (By similarity). Does not mediate adaptive thermogenesis (PubMed:11101840)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis., [RefSeq, PubMed]; Uncoupling Protein 2 Alleviates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Ferroptosis., [RefSeq, PubMed]; Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88285", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015297 antiporter activity;GO:0019003 GDP binding;GO:0015078 proton transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0000303 response to superoxide;GO:0006839 mitochondrial transport;GO:0009409 response to cold;GO:0032869 cellular response to insulin stimulus;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P70406-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DCK3-1", "uniprot_id": [ { "id": "TSN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DCK3", "type": "external" } ], "mass": 26054.0, "length": 238, "protein_name": "Tetraspanin-4", "gene_name": "Tspan4", "organism": "Mouse", "refseq_name": "tetraspanin-4 isoform a", "refseq_ac": [ { "id": "NP_001239517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239517", "type": "external" } ], "gene_names_uniprotkb": "Tspan4; Tm4sf7", "gene_names_refseq": "D130042I01Rik; NAG-2; Tm4sf7; Tspan-4; Tspan4", "protein_names_uniprotkb": "Tetraspanin-4; Transmembrane 4 superfamily member 7; Tspan-4", "protein_names_refseq": "novel antigen 2; tetraspan TM4SF; tetraspanin-4 isoform a; transmembrane 4 superfamily member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:64540)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;36513632", "class_list": "", "function": "TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031982 vesicle;GO:0140494 migrasome;GO:0016020 membrane", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0065003 protein-containing complex assembly;GO:0160040 mitocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9DCK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V129-1", "uniprot_id": [ { "id": "ULK4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V129", "type": "external" } ], "mass": 145342.0, "length": 1303, "protein_name": "Inactive serine/threonine-protein kinase ULK4", "gene_name": "Ulk4", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase ULK4", "refseq_ac": [ { "id": "NP_808257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808257", "type": "external" } ], "gene_names_uniprotkb": "Ulk4", "gene_names_refseq": "4932415A06Rik; A730098P15; Ulk4", "protein_names_uniprotkb": "Inactive serine/threonine-protein kinase ULK4; Pseudokinase ULK4; Unc-51-like kinase 4", "protein_names_refseq": "serine/threonine-protein kinase ULK4", "tax_id": 10090, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (mmu:209012)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "21746835;21750661;24284070;25428506;27300315;27445138;29034508;29187734;31219806;34203471;34428180;35522199;36210013;36989043;38096226", "class_list": "", "function": "Congenital hydrocephalus with suppurative rhinosinusitis and otitis media in Ulk4 null mice indicative of primary ciliary dyskinesis, [RefSeq, PubMed]; Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice., [RefSeq, PubMed]; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility., [UniProtKB, UniProtKB, UniProtKB]; Pseudokinase that acts as a molecular adapter in the smoothened signaling pathway (PubMed:38096226). Required to relieve inhibition of the GLI2 transcription factor in the presence of hedgehog (DHH, IHH or SHH) ligand: acts by mediating the association between STK36 and its ligand GLI2 in ciliary tip, promoting GLI2 phosphorylation and dissociation from SUFU inhibitor, followed by GLI2 translocation to the nucleus (PubMed:38096226)., [UniProtKB, PubMed]; Targeted disruption of the Ulk4 perturbed mid-neurogenesis and significantly reduced cerebral cortex in postnatal mice., [RefSeq, PubMed]; This is the first evidence demonstrating that ULK4 is a crucial regulator of myelination, and ULK4 may therefore become a novel therapeutic target for hypomyelination diseases., [RefSeq, PubMed]; This study showed that Ulk4 Is essential for Ciliogenesis and CSF Flow in mice, [RefSeq, PubMed]; ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2VP87;Q32LZ6;Q8BLS0;Q8C8Z5;Q9D4H6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005929 cilium", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007611 learning or memory;GO:0007613 memory;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q3V129-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJM7-1", "uniprot_id": [ { "id": "TYW1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJM7", "type": "external" } ], "mass": 81599.0, "length": 721, "protein_name": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1", "gene_name": "Tyw1", "organism": "Mouse", "refseq_name": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform 1", "refseq_ac": [ { "id": "NP_001015876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015876", "type": "external" } ], "gene_names_uniprotkb": "Tyw1; Rsafd1", "gene_names_refseq": "Rsafd1; Tyw1", "protein_names_uniprotkb": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; 4.1.3.44; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein", "protein_names_refseq": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 isoform 1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; radical S-adenosyl methionine and flavodoxin domain-containing protein 1; radical S-adenosyl methionine and flavodoxin domains 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:100929)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TRC5;Q8BLG4;Q8R0C7", "ec_number_list": [ { "id": "4.1.3.44", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0010181 FMN binding;GO:0102521 tRNA-4-demethylwyosine synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0031591 wybutosine biosynthetic process;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BJM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D701-1", "uniprot_id": [ { "id": "UPK3L_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D701", "type": "external" } ], "mass": 27250.0, "length": 249, "protein_name": "Uroplakin-3b-like protein 1", "gene_name": "Upk3bl1; Upk3bl", "organism": "Mouse", "refseq_name": "uroplakin-3b-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_081434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081434", "type": "external" } ], "gene_names_uniprotkb": "Upk3bl1; Upk3bl; 2310043J07Rik; Upk3bl", "gene_names_refseq": "2310043J07Rik; Upk3bl1; Upk3bl", "protein_names_uniprotkb": "Uroplakin-3b-like protein 1", "protein_names_refseq": "uroplakin-3-like protein; uroplakin-3b-like protein 1 isoform 1 precursor; uroplakin-3b-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:69665)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;35820727", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0AUM6;Q4KL12", "ec_number_list": [], "go_molecular_function": "GO:0020037 heme binding;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D701-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXT7-1", "uniprot_id": [ { "id": "TM192_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXT7", "type": "external" } ], "mass": 30336.0, "length": 266, "protein_name": "Transmembrane protein 192", "gene_name": "Tmem192", "organism": "Mouse", "refseq_name": "transmembrane protein 192 isoform 2", "refseq_ac": [ { "id": "NP_001157219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157219", "type": "external" } ], "gene_names_uniprotkb": "Tmem192", "gene_names_refseq": "3110005G23Rik; Tmem192", "protein_names_uniprotkb": "Transmembrane protein 192", "protein_names_refseq": "transmembrane protein 192 isoform 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:73067)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19144319;21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3THT5;Q8VDU8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CXT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ML2-1", "uniprot_id": [ { "id": "TNK1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99ML2", "type": "external" } ], "mass": 73099.0, "length": 666, "protein_name": "Non-receptor tyrosine-protein kinase TNK1", "gene_name": "Tnk1", "organism": "Mouse", "refseq_name": "non-receptor tyrosine-protein kinase TNK1", "refseq_ac": [ { "id": "NP_114086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114086", "type": "external" } ], "gene_names_uniprotkb": "Tnk1; Kos1", "gene_names_refseq": "Kos1; Tnk1a; Tnk1b; Tnk1", "protein_names_uniprotkb": "Non-receptor tyrosine-protein kinase TNK1; 2.7.10.2; Kinase of embryonic stem cells", "protein_names_refseq": "kinase of embryonic stem cells; non-receptor tyrosine kinase; non-receptor tyrosine-protein kinase TNK1", "tax_id": 10090, "disease": "", "pathway": " (mmu:83813)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12789265;18974114;19481140;21183079;21750661;24449862;30320600;32694928", "class_list": "", "function": "A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Cellular stress reverses the repression of Tnk1/Kos1 and induces its expression through increased high affinity interactions between nuclear proteins Sp1, Sp3, AP2 and MED1 for the m-Tnk1 promoter, [RefSeq, PubMed]; Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity, [RefSeq, PubMed]; May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway., [UniProtKB, PubMed, PubMed]; TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut., [RefSeq, PubMed]; The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions., [RefSeq, PubMed]; Tnk1/Kos1 is a tumor suppressor that functions to down-regulate Ras activity, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCC4;Q8K0X9;Q91V11", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004674 protein serine/threonine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0046777 protein autophosphorylation;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99ML2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VX2-1", "uniprot_id": [ { "id": "UBAP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91VX2", "type": "external" } ], "mass": 117966.0, "length": 1132, "protein_name": "Ubiquitin-associated protein 2", "gene_name": "Ubap2", "organism": "Mouse", "refseq_name": "ubiquitin-associated protein 2 isoform 1", "refseq_ac": [ { "id": "NP_081148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081148", "type": "external" } ], "gene_names_uniprotkb": "Ubap2; Lig1", "gene_names_refseq": "1190005K07Rik; UBAP-2; Ubap2; mKIAA1491", "protein_names_uniprotkb": "Ubiquitin-associated protein 2; Protein lingerer homolog 1; RNA polymerase II degradation factor Ubap2; UBAP-2; mLig-1", "protein_names_refseq": "MLig-1; RNA polymerase II degradation factor Ubap2; protein lingerer homolog 1; ubiquitin-associated protein 2 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:68926)", "pathway_count": 1, "publication_count": 35, "publication_id_list": "12524348;15592455;19144319;21750661;22517741;22645316;25153642;25428506;25605945;26495903;27669760;28528544;29187734;30016717;30059200;31219806;31599954;32782141;32848054;33300544;34428180;34678516;34887587;35820727;35822049;36288343;36852467;37339951;37828378;37865160;39627609;39927985;40021952;40885482;40997131", "class_list": "", "function": "Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis., [RefSeq, PubMed]; Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage. May promote the degradation of ANXA2., [UniProtKB, UniProtKB]; UBAP2 plays a role in bone homeostasis through the regulation of osteoblastogenesis and osteoclastogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 32, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 32, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 32, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 7, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 32, "binding_glycan_count": 0, "secondary_ac_list": "Q812D6;Q99K40", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 6.9, "record_id": "Q91VX2-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05895-1", "uniprot_id": [ { "id": "TSP3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05895", "type": "external" } ], "mass": 104119.0, "length": 956, "protein_name": "Thrombospondin-3", "gene_name": "Thbs3", "organism": "Mouse", "refseq_name": "thrombospondin-3 precursor", "refseq_ac": [ { "id": "NP_038719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038719", "type": "external" } ], "gene_names_uniprotkb": "Thbs3; Tsp3", "gene_names_refseq": "TSP3; Thbs-3; Thbs3", "protein_names_uniprotkb": "Thrombospondin-3", "protein_names_refseq": "thrombospondin-3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:21827); (R-MMU-186797)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;1601886;21750661;25428506;30622267;31219806;8288588;8468055;8597643;8654563;8871542", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen., [UniProtKB, UniProtKB, UniProtKB]; Study shows that Thbs3 reduces integrin trafficking to the sarcolemma in the heart, while Thbs4 is cardioprotective by augmenting membrane residence of select integrins and beta-dystroglycan of the glycoprotein attachment complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6LCE0;Q7TN15", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm;GO:1990341 thrombospondin complex", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0007155 cell adhesion;GO:0060346 bone trabecula formation;GO:0003417 growth plate cartilage development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q05895-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1H9T6-1", "uniprot_id": [ { "id": "ZBT48_MOUSE", "url": "https://www.uniprot.org/uniprot/Q1H9T6", "type": "external" } ], "mass": 76800.0, "length": 681, "protein_name": "Zinc finger and BTB domain-containing protein 48", "gene_name": "Zbtb48", "organism": "Mouse", "refseq_name": "zinc finger and BTB domain-containing protein 48", "refseq_ac": [ { "id": "NP_598640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598640", "type": "external" } ], "gene_names_uniprotkb": "Zbtb48; Hkr3; Tzap", "gene_names_refseq": "0610011D15Rik; Hkr3; TZAP; Zbtb48", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 48; Krueppel-related zinc finger protein 3 homolog; TZAP; Telomere zinc finger-associated protein", "protein_names_refseq": "GLI-Krueppel family member HKR3; GLI-Kruppel family member HKR3; Krueppel-related zinc finger protein 3 homolog; telomere zinc finger-associated protein; zinc finger and BTB domain-containing protein 48", "tax_id": 10090, "disease": "", "pathway": " (mmu:100090)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;39562739", "class_list": "", "function": "Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A8B1;Q99K15", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1H9T6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z3C6-1", "uniprot_id": [ { "id": "ZFAN4_MOUSE", "url": "https://www.uniprot.org/uniprot/D3Z3C6", "type": "external" } ], "mass": 81554.0, "length": 739, "protein_name": "AN1-type zinc finger protein 4", "gene_name": "Zfand4", "organism": "Mouse", "refseq_name": "AN1-type zinc finger protein 4 isoform 3", "refseq_ac": [ { "id": "NP_001296375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296375", "type": "external" } ], "gene_names_uniprotkb": "Zfand4; Anubl1", "gene_names_refseq": "Anubl1; Zfand4", "protein_names_uniprotkb": "AN1-type zinc finger protein 4; AN1-type zinc finger and ubiquitin domain-containing protein-like 1", "protein_names_refseq": "AN1, ubiquitin-like, homolog; AN1-type zinc finger and ubiquitin domain-containing protein-like 1; AN1-type zinc finger protein 4 isoform 3; AN1-type zinc finger protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:67492)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;30084848;34428180;35820727", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z3C6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1E7-1", "uniprot_id": [ { "id": "TM234_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1E7", "type": "external" } ], "mass": 14922.0, "length": 140, "protein_name": "Transmembrane protein 234", "gene_name": "Tmem234", "organism": "Mouse", "refseq_name": "transmembrane protein 234 isoform 1 precursor", "refseq_ac": [ { "id": "NP_084024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084024", "type": "external" } ], "gene_names_uniprotkb": "Tmem234; 2510006D16Rik", "gene_names_refseq": "1500002D11Rik; 2510006D16Rik; 4933407D05Rik; Tmem234", "protein_names_uniprotkb": "Transmembrane protein 234", "protein_names_refseq": "transmembrane protein 234 isoform 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:76799)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R1E7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08810-1", "uniprot_id": [ { "id": "U5S1_MOUSE", "url": "https://www.uniprot.org/uniprot/O08810", "type": "external" } ], "mass": 109361.0, "length": 971, "protein_name": "116 kDa U5 small nuclear ribonucleoprotein component", "gene_name": "Eftud2", "organism": "Mouse", "refseq_name": "116 kDa U5 small nuclear ribonucleoprotein component isoform b", "refseq_ac": [ { "id": "NP_001103465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103465", "type": "external" } ], "gene_names_uniprotkb": "Eftud2; Snrp116", "gene_names_refseq": "116kDa; Eftud2; Snrp116; U5-116kD", "protein_names_uniprotkb": "116 kDa U5 small nuclear ribonucleoprotein component; Elongation factor Tu GTP-binding domain-containing protein 2; U5 snRNP-specific protein, 116 kDa; U5-116 kDa", "protein_names_refseq": "116 kDa U5 small nuclear ribonucleoprotein component isoform b; 116 kDa U5 small nuclear ribonucleoprotein component; U5 small nuclear ribonucleoprotein 116 kDa; U5 snRNP-specific protein, 116 kDa; U5-116 kDa; elongation factor Tu GTP-binding domain-containing protein 2", "tax_id": 10090, "disease": "mandibulofacial dysostosis, Guion-Almeida type (Disease Ontology:DOID:0080196); esophageal atresia (Disease Ontology:DOID:10485); microcephaly (Disease Ontology:DOID:10907); hepatitis B (Disease Ontology:DOID:2043); Treacher Collins syndrome (Disease Ontology:DOID:2908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (mmu:20624); (R-MMU-72163); (R-MMU-72165)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;21750661;25428506;25605945;26495903;30084848;30779550;31219806;33300544;34428180;39153477;39627609;9233818", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030623 U5 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0071466 cellular response to xenobiotic stimulus;GO:0042220 response to cocaine;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08810-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08042-1", "uniprot_id": [ { "id": "ZFP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P08042", "type": "external" } ], "mass": 46511.0, "length": 402, "protein_name": "Zinc finger protein 1", "gene_name": "Zfp1", "organism": "Mouse", "refseq_name": "zinc finger protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001032754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032754", "type": "external" } ], "gene_names_uniprotkb": "Zfp1; Fnp-1; Zfp-1", "gene_names_refseq": "Fnp-1; Zfp-1; Zfp1; mkr-1", "protein_names_uniprotkb": "Zinc finger protein 1; Protein mKR1; Zfp-1", "protein_names_refseq": "protein mKR1; zinc finger protein 1 isoform 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:22640); (R-MMU-212436)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20624068;21750661;21952136;2574853;29187734;30084848;3815523", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16074;Q7TNS0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P08042-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BWP5-1", "uniprot_id": [ { "id": "TTPA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BWP5", "type": "external" } ], "mass": 32014.0, "length": 278, "protein_name": "Alpha-tocopherol transfer protein", "gene_name": "Ttpa", "organism": "Mouse", "refseq_name": "alpha-tocopherol transfer protein isoform 1", "refseq_ac": [ { "id": "NP_056582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056582", "type": "external" } ], "gene_names_uniprotkb": "Ttpa", "gene_names_refseq": "Ttpa; alpha-TTP", "protein_names_uniprotkb": "Alpha-tocopherol transfer protein; Alpha-TTP", "protein_names_refseq": "alpha TTP; alpha-tocopherol transfer protein isoform 1; alpha-tocopherol transfer protein", "tax_id": 10090, "disease": "familial isolated deficiency of vitamin E (Disease Ontology:DOID:0090028); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (mmu:50500); (R-MMU-8877627)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12135902;21750661;23599266;33086686;34428180;35150738;39179163", "class_list": "", "function": "Alpha-Tocomonoenol Is Bioavailable in Mice and May Partly Be Regulated by the Function of the Hepatic alphaTocopherol Transfer Protein. Publication Status: Online-Only, [RefSeq, PubMed]; Alpha-tocopherol plays a role in the process of implantation, [RefSeq, PubMed]; Binds (+)-alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol., [UniProtKB, PubMed]; Interneurons in the CA1 stratum oriens expressing alphaTTP may play a role in the delayed-ageing Pol mu mouse model., [RefSeq, PubMed]; The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CW51;Q9JL07", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019842 vitamin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0008431 vitamin E binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005770 late endosome", "go_biological_process": "GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0001890 placenta development;GO:0009636 response to toxic substance;GO:0009268 response to pH;GO:1900223 positive regulation of amyloid-beta clearance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BWP5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XL3-1", "uniprot_id": [ { "id": "UXS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XL3", "type": "external" } ], "mass": 47553.0, "length": 420, "protein_name": "UDP-glucuronic acid decarboxylase 1", "gene_name": "Uxs1", "organism": "Mouse", "refseq_name": "UDP-glucuronic acid decarboxylase 1 isoform 2", "refseq_ac": [ { "id": "NP_080706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080706", "type": "external" } ], "gene_names_uniprotkb": "Uxs1", "gene_names_refseq": "1600025I13Rik; Uxs1", "protein_names_uniprotkb": "UDP-glucuronic acid decarboxylase 1; 4.1.1.35; UDP-glucuronate decarboxylase 1; UGD; UXS-1", "protein_names_refseq": "UDP-glucuronic acid decarboxylase 1 isoform 2; UDP-glucuronic acid decarboxylase 1; UGD; UXS-1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67883); (R-MMU-173599); (R-MMU-1971475)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "17322886;19892989;21750661;25605945;26495903;29187734;31219806;34428180;35984892;37828378", "class_list": "glycogene", "function": "Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Catalyzes the synthesis of UDP-xylose in two steps: the hydroxyl group of UDP-glucuronic acid is first oxidized using an enzyme-bound NAD(+) as electron acceptor, favoring the decarboxylation yielding a UDP-4-ketoxylose reaction intermediate and a reduced cofactor NADH bound to the catalytic pocket. In the second step, the 4-keto group is reduced resulting in UDP-xylose and the restoration of the enzyme to its NAD(+)-bound form., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U854", "ec_number_list": [ { "id": "4.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070403 NAD+ binding;GO:0048040 UDP-glucuronate decarboxylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0042732 D-xylose metabolic process;GO:0006024 glycosaminoglycan biosynthetic process;GO:0033320 UDP-D-xylose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q91XL3-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES34-1", "uniprot_id": [ { "id": "UBE3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ES34", "type": "external" } ], "mass": 122762.0, "length": 1070, "protein_name": "Ubiquitin-protein ligase E3B", "gene_name": "Ube3b", "organism": "Mouse", "refseq_name": "ubiquitin-protein ligase E3B isoform 1", "refseq_ac": [ { "id": "NP_473434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_473434", "type": "external" } ], "gene_names_uniprotkb": "Ube3b", "gene_names_refseq": "Ube3b", "protein_names_uniprotkb": "Ubiquitin-protein ligase E3B; 2.3.2.26; HECT-type ubiquitin transferase E3B", "protein_names_refseq": "HECT-type ubiquitin transferase E3B; ubiquitin-protein ligase E3B isoform 1", "tax_id": 10090, "disease": "Kaufman oculocerebrofacial syndrome (Disease Ontology:DOID:0111456)", "pathway": " (mmu:117146); (R-MMU-983168)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12837265;21750661;23200864;30808755;31219806;32249816;34428180;36623761", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes (PubMed:30808755). Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC (PubMed:30808755, PubMed:32249816)., [UniProtKB, PubMed, PubMed]; Our data reveal the pleiotropic effects of UBE3B deficiency and reinforce the physiological importance of ubiquitination in neuronal development and function in mammals., [RefSeq, PubMed]; The murine ortholog of Kaufman oculocerebrofacial syndrome gene Ube3b is crucial for the maintenance of the excitatory synapses in the young adult stage., [RefSeq, PubMed]; The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K068", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005739 mitochondrion;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ES34-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z273-1", "uniprot_id": [ { "id": "TULP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z273", "type": "external" } ], "mass": 60336.0, "length": 543, "protein_name": "Tubby-related protein 1", "gene_name": "Tulp1", "organism": "Mouse", "refseq_name": "tubby-related protein 1", "refseq_ac": [ { "id": "NP_067453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067453", "type": "external" } ], "gene_names_uniprotkb": "Tulp1", "gene_names_refseq": "Tulp1l; Tulp1", "protein_names_uniprotkb": "Tubby-related protein 1; Tubby-like protein 1", "protein_names_refseq": "tubby like protein 1 like; tubby-like protein 1; tubby-related protein 1", "tax_id": 10090, "disease": "Leber congenital amaurosis 15 (Disease Ontology:DOID:0110189); retinitis pigmentosa 14 (Disease Ontology:DOID:0110381); retinitis pigmentosa (Disease Ontology:DOID:10584); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:22157)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;11481257;17525220;19218615;19695251;19718693;19837063;20978472;21540332;21750661;26911694;33213002;34360830", "class_list": "", "function": "Photoreceptor Compartment-Specific TULP1 Interactomes. Publication Status: Online-Only, [RefSeq, PubMed]; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments. Publication Status: Online-Only, [RefSeq, PubMed]; Tulp1 is essential to keep endocytotic proteins enriched at the periactive zone in photoreceptor ribbon synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043679 axon terminus", "go_biological_process": "GO:0016358 dendrite development;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0001895 retina homeostasis;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z273-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3TTC2-1", "uniprot_id": [ { "id": "TYY2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3TTC2", "type": "external" } ], "mass": 42031.0, "length": 378, "protein_name": "Transcription factor YY2", "gene_name": "Mbtps2; Yy2", "organism": "Mouse", "refseq_name": "transcription factor YY2", "refseq_ac": [ { "id": "NP_001092193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092193", "type": "external" } ], "gene_names_uniprotkb": "Mbtps2; Yy2", "gene_names_refseq": "Yy2", "protein_names_uniprotkb": "Transcription factor YY2; YY-2; Yin and yang 2", "protein_names_refseq": "YY-2; transcription factor YY2; yin and yang 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:100073351)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16260628;16377127;17478514;19638226;21750661;26350623;27561171;31499192", "class_list": "", "function": "Both the up- and down-regulation of yy2 significantly impairs the outgrowth of the major neurite of primary hippocampal neurons and the numbers of neuronal processes in proximate extensions, [RefSeq, PubMed]; Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation., [UniProtKB, PubMed]; In a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated, [RefSeq, PubMed]; PTBP1 is a critical regulator of vascular smooth muscle cell proliferation and neointima hyperplasia via modulating the expression of YY2., [RefSeq, PubMed]; The novel factor YY2 antagonizes the negative actions exerted by YY1, [RefSeq, PubMed]; Yy2 expression in the heart and lung is constitutively expressed during embryogenesis and in adult mice. Developmental changes of yy2 transcription became obvious in various areas of the brain. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CBG3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0031519 PcG protein complex;GO:0016020 membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q3TTC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z255-1", "uniprot_id": [ { "id": "UBE2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z255", "type": "external" } ], "mass": 17315.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 A", "gene_name": "Ube2a", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 A isoform 1", "refseq_ac": [ { "id": "NP_062642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062642", "type": "external" } ], "gene_names_uniprotkb": "Ube2a; Rad6a", "gene_names_refseq": "HHR6A; HR6A; Mhr6a; Ube2a", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 A; 2.3.2.23; E2 ubiquitin-conjugating enzyme A; HR6A; RAD6 homolog A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A; mHR6A", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme A; RAD6 homolog A; ubiquitin carrier protein A; ubiquitin-conjugating enzyme E2 A isoform 1; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme HR6A; ubiquitin-protein ligase A", "tax_id": 10090, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); syndromic X-linked intellectual disability Nascimento type (Disease Ontology:DOID:0060820); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (mmu:22209); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-983168)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12172006;12525704;15169909;21750661;23685073;26476408", "class_list": "", "function": "Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice., [RefSeq, PubMed]; E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (By similarity). In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination (By similarity). Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1 (By similarity). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). Involved in mitophagy by acting as a E2 ubiquitin-conjugating enzyme for PRKN (PubMed:23685073). In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation (By similarity). In association with the E3 ubiquitin-protein ligase complex SIFI, inhibits the mitochondrial stress response by acting as a E2 ubiquitin-conjugating enzyme for UBR4 and KCMF1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results indicate a causal role of UBE2A in learning and mGLUR-dependent long-term depression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005770 late endosome;GO:0000785 chromatin;GO:0001741 XY body;GO:0033503 HULC complex", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0001701 in utero embryonic development;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z255-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91YN5-1", "uniprot_id": [ { "id": "UAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91YN5", "type": "external" } ], "mass": 58609.0, "length": 522, "protein_name": "UDP-N-acetylhexosamine pyrophosphorylase", "gene_name": "Uap1", "organism": "Mouse", "refseq_name": "UDP-N-acetylhexosamine pyrophosphorylase isoform 1", "refseq_ac": [ { "id": "NP_001291974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291974", "type": "external" } ], "gene_names_uniprotkb": "Uap1", "gene_names_refseq": "AGX-1; AGX-2; AGX1; AgX; ESTM38; SPAG2; Uap1", "protein_names_uniprotkb": "UDP-N-acetylhexosamine pyrophosphorylase; 2.7.4.-; 2.7.7.23; 2.7.7.83; Protein-pyrophosphorylation enzyme; UDP-N-acetylgalactosamine pyrophosphorylase; UDP-N-acetylglucosamine pyrophosphorylase", "protein_names_refseq": "UDP-N-acetylgalactosamine pyrophosphorylase; UDP-N-acetylhexosamine pyrophosphorylase isoform 1; UDP-N-acetylhexosamine pyrophosphorylase; antigen X; protein-pyrophosphorylation enzyme; sperm associated antigen 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:107652); (R-MMU-446210)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;21750661;26740625;28011936;34428180;36603579;37828378", "class_list": "glycogene", "function": "Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide (By similarity). Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc) (By similarity). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection (PubMed:36603579). Regulates innate immunity by catalyzing pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses (By similarity)., [UniProtKB, PubMed, UniProtKB]; Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 18, "reported_interactions": 0, "missing_score": 9718, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG76;Q8BXD6;Q8VD59", "ec_number_list": [ { "id": "2.7.7.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.23", "type": "external" }, { "id": "2.7.7.83", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.83", "type": "external" }, { "id": "2.7.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity;GO:0052630 UDP-N-acetylgalactosamine diphosphorylase activity;GO:0141090 protein serine pyrophosphorylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process;GO:0032481 positive regulation of type I interferon production;GO:0140374 antiviral innate immune response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91YN5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.000.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN37-1", "uniprot_id": [ { "id": "TRPM4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN37", "type": "external" } ], "mass": 135760.0, "length": 1213, "protein_name": "Transient receptor potential cation channel subfamily M member 4", "gene_name": "Trpm4", "organism": "Mouse", "refseq_name": "transient receptor potential cation channel subfamily M member 4 isoform 1", "refseq_ac": [ { "id": "NP_780339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780339", "type": "external" } ], "gene_names_uniprotkb": "Trpm4; Ltrpc4", "gene_names_refseq": "1110030C19Rik; LTRPC4; LTrpC-4; TRPM4B; Trpm4", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 4; Calcium-activated non-selective cation channel 1; LTrpC-4; LTrpC4; Long transient receptor potential channel 4", "protein_names_refseq": "calcium-activated non-selective cation channel 1; long transient receptor potential channel 4; transient receptor potential cation channel subfamily M member 4 isoform 1; transient receptor potential ion channel melastatin subgroup member 4", "tax_id": 10090, "disease": "cardiac arrest (Disease Ontology:DOID:0060319); erythrokeratodermia variabilis et progressiva 6 (Disease Ontology:DOID:0080766); progressive familial heart block type IB (Disease Ontology:DOID:0111076)", "pathway": " (mmu:68667); (R-MMU-3295583)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "12799367;12893253;15670874;16186107;17188667;18758465;21183079;21750661;29211714;31219806;37522838;37604672;38098265;38183495;38999984", "class_list": "", "function": "Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:17188667, PubMed:29211714). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells (PubMed:18758465). Plays a role in keratinocyte differentiation (By similarity) (PubMed:18758465)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Functional coupling between Piezo1 and TRPM4 influences the electrical activity of HL-1 atrial myocytes., [RefSeq, PubMed]; Hydrolysis of PI(4,5)P(2) underlies desensitization of TRPM4, and PI(4,5)P(2) is a general regulator for the gating of TRPM ion channels, [RefSeq, PubMed]; In Silico Electrophysiological Investigation of Transient Receptor Potential Melastatin-4 Ion Channel Biophysics to Study Detrusor Overactivity. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice., [RefSeq, PubMed]; Lacks channel activity., [UniProtKB, UniProtKB]; Molecular cloning and characterization of TRPM4., [RefSeq, PubMed]; Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis., [RefSeq, PubMed]; TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose., [RefSeq, PubMed]; TRPM5 activated at lower Ca2+ concentration than TRPM4 when [Ca2+]i was raised. Different Ca2+ concentrations gave a difference in Ca2+ sensitivity between TRPM4 and TRPM5, with EC50 values of 20.2+/-4.0 microM & 0.70+/-0.1 microM, respectively., [RefSeq, PubMed]; Voltage dependence is not due to block by divalent cations or to voltage-dependent binding of intracellular Ca2+ to an activator site, indicating that TRPM4 is a transient receptor potential channel with an intrinsic voltage-sensing mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDM0;Q769E2;Q769E4;Q80Y94;Q80YB3;Q811E2", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0086048 membrane depolarization during bundle of His cell action potential;GO:1904179 positive regulation of adipose tissue development;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7TN37-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCI0-1", "uniprot_id": [ { "id": "URGCP_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCI0", "type": "external" } ], "mass": 104683.0, "length": 926, "protein_name": "Up-regulator of cell proliferation", "gene_name": "Urgcp", "organism": "Mouse", "refseq_name": "up-regulator of cell proliferation isoform 2", "refseq_ac": [ { "id": "NP_001071129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071129", "type": "external" } ], "gene_names_uniprotkb": "Urgcp; Urg4", "gene_names_refseq": "2010005J08Rik; 9130001I21Rik; Urg4; Urgcp; mKIAA1507", "protein_names_uniprotkb": "Up-regulator of cell proliferation; HBV X protein up-regulated gene 4 protein homolog; HBxAg up-regulated gene 4 protein homolog", "protein_names_refseq": "HBV X protein up-regulated gene 4 protein homolog; HBxAg up-regulated gene 4 protein homolog; protein URG4; up-regulator of cell proliferation isoform 2; up-regulator of cell proliferation", "tax_id": 10090, "disease": "", "pathway": " (mmu:72046)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "May be involved in cell cycle progression through the regulation of cyclin D1 expression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0PJ66;Q3TLI5;Q8C9K3;Q8CBP7;Q8CC98", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5NCI0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1K2-1", "uniprot_id": [ { "id": "VATF_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1K2", "type": "external" } ], "mass": 13370.0, "length": 119, "protein_name": "V-type proton ATPase subunit F", "gene_name": "Atp6v1f", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit F", "refseq_ac": [ { "id": "NP_079657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079657", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1f; Atp6s14; Vatf", "gene_names_refseq": "1110004G16Rik; Atp6v1f", "protein_names_uniprotkb": "V-type proton ATPase subunit F; V-ATPase 14 kDa subunit; V-ATPase subunit F; Vacuolar proton pump subunit F", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit F; ATPase, vacuolar, 14 kD; V-ATPase 14 kDa subunit; V-ATPase subunit F; V-type proton ATPase subunit F; vacuolar proton pump subunit F", "tax_id": 10090, "disease": "", "pathway": " (mmu:66144); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15976442;21750661;30084848;30779550;34428180;35820727", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Vacuolar F(1)F(0) ATPase was found to be crucial for osmoregulation, the phagocytotic pathway and the biogenesis of dense core secretory granules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3U6X0", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9D1K2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52624-1", "uniprot_id": [ { "id": "UPP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P52624", "type": "external" } ], "mass": 34086.0, "length": 311, "protein_name": "Uridine phosphorylase 1", "gene_name": "Upp1", "organism": "Mouse", "refseq_name": "uridine phosphorylase 1", "refseq_ac": [ { "id": "NP_001152873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152873", "type": "external" } ], "gene_names_uniprotkb": "Upp1; Upp; Up", "gene_names_refseq": "UPase; UdRPase; Upp1; Upp; Up", "protein_names_uniprotkb": "Uridine phosphorylase 1; 2.4.2.3; UPase 1; UrdPase 1", "protein_names_refseq": "UPase 1; urdPase 1; uridine phosphorylase 1", "tax_id": 10090, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (mmu:22271); (R-MMU-73614); (R-MMU-73621)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12077348;15772079;21750661;30084848;34428180;7744869", "class_list": "", "function": "Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12077348, PubMed:15772079, PubMed:7744869). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed:12077348, PubMed:7744869)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZX0", "ec_number_list": [ { "id": "2.4.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.3", "type": "external" } ], "go_molecular_function": "GO:0004850 uridine phosphorylase activity;GO:0042802 identical protein binding;GO:0009032 thymidine phosphorylase activity;GO:0047847 deoxyuridine phosphorylase activity;GO:0016763 pentosyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006218 uridine catabolic process;GO:0044206 UMP salvage;GO:0042149 cellular response to glucose starvation;GO:0046108 uridine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52624-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SRX1-1", "uniprot_id": [ { "id": "TM1L2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SRX1", "type": "external" } ], "mass": 55663.0, "length": 507, "protein_name": "TOM1-like protein 2", "gene_name": "Tom1l2", "organism": "Mouse", "refseq_name": "TOM1-like protein 2 isoform b", "refseq_ac": [ { "id": "NP_001034181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034181", "type": "external" } ], "gene_names_uniprotkb": "Tom1l2", "gene_names_refseq": "2900016I08Rik; A730055F12Rik; Srebf1; Tom1l2", "protein_names_uniprotkb": "TOM1-like protein 2; Target of Myb-like protein 2", "protein_names_refseq": "TOM1-like protein 2 isoform b; TOM1-like protein 2; myb1-like protein 2; target of Myb-like protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:216810)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "11997338;17114649;18280001;18343975;21183079;21750661;22517741;22645316;22826440;25428506;32782141;32848054;33300544;34428180;34678516;35820727;36288343;37019113;40021952;40885482", "class_list": "", "function": "Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (By similarity). May also play a role in recruiting clathrin to endosomes (By similarity). May regulate growth factor-induced mitogenic signaling (By similarity)., [UniProtKB, UniProtKB]; Consistent with pathways of hepatic triglyceride synthesis, expression of diacylglycerol acyltransferase-1 and -2 was increased, as were delta-5- and delta-6- fatty acid desaturase mRNA levels., [RefSeq, PubMed]; The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia., [RefSeq, PubMed]; Tom1l2plays a role in the immune response and possibly in tumor suppression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0JP66;Q5SRX7;Q5SRY0;Q6P5D7;Q8C6J0;Q8C935;Q8CB51;Q8R4H1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030276 clathrin binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0045839 negative regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q5SRX1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVE3-1", "uniprot_id": [ { "id": "VATH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVE3", "type": "external" } ], "mass": 55855.0, "length": 483, "protein_name": "V-type proton ATPase subunit H", "gene_name": "Atp6v1h", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit H isoform 2", "refseq_ac": [ { "id": "NP_001297371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297371", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1h", "gene_names_refseq": "0710001F19Rik; Atp6v1h; CGI-11; SFDalpha; SFDbeta; SFD; VMA13", "protein_names_uniprotkb": "V-type proton ATPase subunit H; V-ATPase subunit H; Vacuolar proton pump subunit H", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; H+ transporting ATPase lysosomal V1 subunit H; V-ATPase H subunit; V-ATPase subunit H; V-type proton ATPase subunit H isoform 2; V-type proton ATPase subunit H; vacuolar ATP synthase subunit H; vacuolar ATPase subunit H; vacuolar proton pump H subunit; vacuolar proton pump subunit H", "tax_id": 10090, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (mmu:108664); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "21183079;21750661;22872234;25605945;26740625;31219806;33300544;34203471;34428180;37507081;37824389;38203808", "class_list": "", "function": "Atp6v1h Deficiency Blocks Bone Loss in Simulated Microgravity Mice through the Fos-Jun-Src-Integrin Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Long Noncoding RNA lnc-TCEA1-3 Affects Osteoclastic Function by Regulating ATP6V1H., [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q921X8", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0097401 synaptic vesicle lumen acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BVE3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08071-1", "uniprot_id": [ { "id": "TRFL_MOUSE", "url": "https://www.uniprot.org/uniprot/P08071", "type": "external" } ], "mass": 77838.0, "length": 707, "protein_name": "Lactotransferrin", "gene_name": "Ltf", "organism": "Mouse", "refseq_name": "lactotransferrin precursor", "refseq_ac": [ { "id": "NP_032548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032548", "type": "external" } ], "gene_names_uniprotkb": "Ltf", "gene_names_refseq": "Csp82; Lf; Ltf; MMS10R; Ms10r", "protein_names_uniprotkb": "Lactotransferrin; 3.4.21.-; Lactoferrin", "protein_names_refseq": "N lobe; lactoferrin; lactotransferrin precursor; minisatellite 10r detected by probe MMS10", "tax_id": 10090, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); prostate calculus (Disease Ontology:DOID:13689); candidiasis (Disease Ontology:DOID:1508); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); connective tissue disease (Disease Ontology:DOID:65)", "pathway": " (mmu:17002); (R-MMU-6798695); (R-MMU-6799990); (R-MMU-6803157)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;1939212;21750661;34428180;3611056;39627609", "class_list": "", "function": "Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site., [UniProtKB, UniProtKB]; Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA., [UniProtKB, UniProtKB]; The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites., [UniProtKB, UniProtKB]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70690;Q61799;Q8CBA0;Q922P2", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005506 iron ion binding;GO:0008201 heparin binding;GO:0008233 peptidase activity;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P08071-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10078-1", "uniprot_id": [ { "id": "ZFP28_MOUSE", "url": "https://www.uniprot.org/uniprot/P10078", "type": "external" } ], "mass": 93309.0, "length": 825, "protein_name": "Zinc finger protein 28", "gene_name": "Zfp28", "organism": "Mouse", "refseq_name": "zinc finger protein 28", "refseq_ac": [ { "id": "NP_780456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780456", "type": "external" } ], "gene_names_uniprotkb": "Zfp28; Mkr5; Zfp-28", "gene_names_refseq": "2810438M17Rik; Zfp-28; Zfp28; mkr-5", "protein_names_uniprotkb": "Zinc finger protein 28; Protein mKR5; Zfp-28", "protein_names_refseq": "protein mKR5; zinc finger protein 28", "tax_id": 10090, "disease": "", "pathway": " (mmu:22690); (R-MMU-212436)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19329283;21750661;3143103;7958967", "class_list": "", "function": "May be involved in transcriptional regulation. May have a role in embryonic development., [UniProtKB]; These results suggest that murine and human Zfp28/ZFP28 is correlated with the pathogenesis of melanoma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61776;Q8BT11;Q8C836", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10078-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2A5E6-1", "uniprot_id": [ { "id": "Z385C_MOUSE", "url": "https://www.uniprot.org/uniprot/A2A5E6", "type": "external" } ], "mass": 44644.0, "length": 429, "protein_name": "Zinc finger protein 385C", "gene_name": "Zfp385c; Znf385c", "organism": "Mouse", "refseq_name": "zinc finger protein 385C isoform 5", "refseq_ac": [ { "id": "NP_808458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808458", "type": "external" } ], "gene_names_uniprotkb": "Zfp385c; Znf385c; Zfp385c", "gene_names_refseq": "A930006D11Rik; Zfp385c; Znf385c", "protein_names_uniprotkb": "Zinc finger protein 385C", "protein_names_refseq": "zinc finger protein 385C isoform 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:278304)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;35820727", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q14AS5;Q8C8X1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2A5E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K2W3-1", "uniprot_id": [ { "id": "TXD11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K2W3", "type": "external" } ], "mass": 105959.0, "length": 948, "protein_name": "Thioredoxin domain-containing protein 11", "gene_name": "Txndc11", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 11 isoform 1", "refseq_ac": [ { "id": "NP_083858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083858", "type": "external" } ], "gene_names_uniprotkb": "Txndc11", "gene_names_refseq": "2810408E11Rik; EFP1; Txdc11; Txndc11", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 11", "protein_names_refseq": "EF-hand binding protein 1; thioredoxin domain-containing protein 11 isoform 1; thioredoxin domain-containing protein 11", "tax_id": 10090, "disease": "", "pathway": " (mmu:106200); (R-MMU-209968)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;21750661;30059200;31219806", "class_list": "", "function": "May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BMR8;Q8VCK9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8K2W3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN22-1", "uniprot_id": [ { "id": "TXD16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TN22", "type": "external" } ], "mass": 92105.0, "length": 820, "protein_name": "Thioredoxin domain-containing protein 16", "gene_name": "Txndc16", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 16 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001297463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297463", "type": "external" } ], "gene_names_uniprotkb": "Txndc16; Kiaa1344", "gene_names_refseq": "5730420B22Rik; Txndc16", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 16", "protein_names_refseq": "thioredoxin domain-containing protein 16 isoform 1 precursor; thioredoxin domain-containing protein 16", "tax_id": 10090, "disease": "", "pathway": " (mmu:70561)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;21750661;22872234;30084848;31219806;34203471;34428180;36210013", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q69ZL5;Q8BL40;Q8R2W8;Q9CS82", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q7TN22-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1G3-1", "uniprot_id": [ { "id": "VATC1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1G3", "type": "external" } ], "mass": 43888.0, "length": 382, "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "Atp6v1c1", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit C 1", "refseq_ac": [ { "id": "NP_079770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079770", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1c1; Atp6c1; Atp6c; Vatc", "gene_names_refseq": "1700025B18Rik; Atp6v1c1", "protein_names_uniprotkb": "V-type proton ATPase subunit C 1; V-ATPase subunit C 1; Vacuolar proton pump subunit C 1", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit C; V-ATPase subunit C 1; V-type proton ATPase subunit C 1; vacuolar proton pump subunit C 1", "tax_id": 10090, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); cancer (Disease Ontology:DOID:162); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (mmu:66335); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;12527205;21750661;25428506;30781750;31104818;31219806;33300544;34428180;36210013;37828378", "class_list": "", "function": "MIR29a plays an important role during the trans-differentiation of Activated hepatic stellate cells in the resolution of liver fibrosis, in part, through regulation of ATP6V1C1. Publication Status: Online-Only, [RefSeq, PubMed]; Results showed that adneno-associated virus-mediated Atp6v1c1 knockdown in periapical tissues slowed endodontic disease progression, prevented bone erosion, and alleviated inflammation in the periapical tissues and periodontal ligament potentially through regulation of toll-like receptor signaling, [RefSeq, PubMed]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91Z42", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification;GO:0038020 insulin receptor recycling", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z1G3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21761-1", "uniprot_id": [ { "id": "TRHR_MOUSE", "url": "https://www.uniprot.org/uniprot/P21761", "type": "external" } ], "mass": 44559.0, "length": 393, "protein_name": "Thyrotropin-releasing hormone receptor", "gene_name": "Trhr", "organism": "Mouse", "refseq_name": "thyrotropin-releasing hormone receptor", "refseq_ac": [ { "id": "NP_038724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038724", "type": "external" } ], "gene_names_uniprotkb": "Trhr", "gene_names_refseq": "TRH-R1; Trhr", "protein_names_uniprotkb": "Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor", "protein_names_refseq": "TRH-R; thyroliberin receptor; thyrotropin-releasing hormone receptor", "tax_id": 10090, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nongoitrous hypothyroidism 7 (Disease Ontology:DOID:0111836); hypertension (Disease Ontology:DOID:10763)", "pathway": " (mmu:22045); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;11181534;1324930;21750661;2175902;9156522", "class_list": "", "function": "Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004997 thyrotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0031334 positive regulation of protein-containing complex assembly;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21761-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UJD6-1", "uniprot_id": [ { "id": "UBP19_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UJD6", "type": "external" } ], "mass": 150549.0, "length": 1360, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 19", "gene_name": "Usp19", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 19 isoform 2", "refseq_ac": [ { "id": "NP_001161843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161843", "type": "external" } ], "gene_names_uniprotkb": "Usp19; Kiaa0891", "gene_names_refseq": "8430421I07Rik; Usp19; Zmynd9", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 19; 3.4.19.12; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19", "protein_names_refseq": "deubiquitinating enzyme 19; ubiquitin carboxyl-terminal hydrolase 19 isoform 2; ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific processing protease 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:71472); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "19015242;21183079;21750661;21971047;25088257;25428506;25568336;27827840;29093475;30084848;30779550;31127032;31219806;33097834;34428180;39627609", "class_list": "", "function": "Deubiquitinating enzyme that regulates the degradation of various proteins by removing ubiquitin moieties, thereby preventing their proteasomal degradation. Stabilizes RNF123, which promotes CDKN1B degradation and contributes to cell proliferation (By similarity). Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis (PubMed:25568336). Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (PubMed:25088257, PubMed:27827840). Mechanistically, deubiquitinates and thereby stabilizes several E3 ligases involved in the ERAD pathway including SYVN1 or MARCHF6 (PubMed:25088257, PubMed:27827840). Regulates the stability of other E3 ligases including BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia by rescuing HIF1A from degradation in a non-catalytic manner and by mediating the deubiquitination of FUNDC1. Attenuates mitochondrial damage and ferroptosis by targeting and stabilizing NADPH oxidase 4/NOX4 (By similarity). Negatively regulates TNF- and IL-1beta-triggered NF-kappa-B activation by hydrolyzing 'Lys-27'- and 'Lys-63'-linked polyubiquitin chains from MAP3K7 (PubMed:31127032). Modulates also the protein level and aggregation of polyQ-expanded huntingtin/HTT through HSP90AA1 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression., [RefSeq, PubMed]; Study reports that the USP19 deubiquitinating enzyme interacts with and stabilizes KPC1, thereby modulating p27(Kip1) levels and cell proliferation Erratum:[Mol Cell Biol. 2009 Jun;29(11):3241], [RefSeq, PubMed]; USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3TAC9;Q3TUE6;Q6P9T0;Q80TP5;Q80ZW5", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0051879 Hsp90 protein binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904292 regulation of ERAD pathway;GO:0016579 protein deubiquitination;GO:0050821 protein stabilization;GO:0031647 regulation of protein stability;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q3UJD6-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKP2-1", "uniprot_id": [ { "id": "UBP13_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5BKP2", "type": "external" } ], "mass": 96723.0, "length": 858, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 13", "gene_name": "Usp13", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 13", "refseq_ac": [ { "id": "NP_001013042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013042", "type": "external" } ], "gene_names_uniprotkb": "Usp13", "gene_names_refseq": "2700071E21Rik; ISOT3; IsoT-3; Usp13", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 13; 3.4.19.12; Deubiquitinating enzyme 13; Ubiquitin thioesterase 13; Ubiquitin-specific-processing protease 13", "protein_names_refseq": "deubiquitinating enzyme 13; ubiquitin carboxyl-terminal hydrolase 13; ubiquitin specific protease 13 (isopeptidase T-3); ubiquitin thioesterase 13; ubiquitin-specific-processing protease 13", "tax_id": 10090, "disease": "", "pathway": " (mmu:72607); (R-MMU-5689880); (R-MMU-8948751)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21750661;21913724;28534493;31204278;32434004;36150040;37311811;37634814;38093367;39033101", "class_list": "", "function": "Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells., [RefSeq, PubMed]; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB. In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1. Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion. Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1., [UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation, [RefSeq, PubMed]; USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1. Publication Status: Online-Only, [RefSeq, PubMed]; USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation., [RefSeq, PubMed]; USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Publication Status: Online-Only, [RefSeq, PubMed]; USP13 regulates cell senescence through mediating MDM2 stability., [RefSeq, PubMed]; Usp13 deconjugates polyubiquitin chains from STING and prevents the recruitment of Tbk1 to the signalling complex, thereby negatively regulating cellular antiviral responses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YYG7", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:1904288 BAT3 complex binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy;GO:0070536 protein K63-linked deubiquitination;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5BKP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAM5-1", "uniprot_id": [ { "id": "TPC_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAM5", "type": "external" } ], "mass": 35618.0, "length": 318, "protein_name": "Mitochondrial thiamine pyrophosphate carrier", "gene_name": "Slc25a19", "organism": "Mouse", "refseq_name": "mitochondrial thiamine pyrophosphate carrier isoform 1", "refseq_ac": [ { "id": "NP_001239313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239313", "type": "external" } ], "gene_names_uniprotkb": "Slc25a19", "gene_names_refseq": "2900089E13Rik; DNC; MUP1; Slc25a19; TPC", "protein_names_uniprotkb": "Mitochondrial thiamine pyrophosphate carrier; Solute carrier family 25 member 19", "protein_names_refseq": "mitochondrial thiamine pyrophosphate carrier isoform 1; mitochondrial thiamine pyrophosphate carrier; solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19; solute carrier family 25 member 19", "tax_id": 10090, "disease": "microcephaly (Disease Ontology:DOID:10907); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (mmu:67283); (R-MMU-196819)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17035501;18280798;21750661;26316591", "class_list": "", "function": "Chronic alcohol exposure negatively impacts pancreatic mitochondrial thiamin pyrophosphate transport, and this effect is exerted, at least in part, at the level of Slc25a19 transcription and appears to involve an epigenetic mechanism., [RefSeq, PubMed]; Mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively, [RefSeq, PubMed]; Mitochondrial transporter mediating uptake of thiamine diphosphate into mitochondria. It is not clear if the antiporter activity is affected by the membrane potential or by the proton electrochemical gradient., [UniProtKB, UniProtKB]; We review the evidence that the function of the SLC25A19 gene product, previously identified as the mitochondrial deoxyribonucleotide carrier (DNC), is actually the transport of thiamine pyrophosphate.[review] Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2A9V6;Q3T9C4", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0090422 thiamine pyrophosphate transmembrane transporter activity;GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0009229 thiamine diphosphate biosynthetic process;GO:0030974 thiamine pyrophosphate transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9DAM5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ61-1", "uniprot_id": [ { "id": "UNC50_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ61", "type": "external" } ], "mass": 30429.0, "length": 259, "protein_name": "Protein unc-50 homolog", "gene_name": "Unc50", "organism": "Mouse", "refseq_name": "protein unc-50 homolog", "refseq_ac": [ { "id": "NP_080399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080399", "type": "external" } ], "gene_names_uniprotkb": "Unc50", "gene_names_refseq": "1110002A21Rik; GMH1; UNCL; URP; Unc50", "protein_names_uniprotkb": "Protein unc-50 homolog; PDLs22; Periodontal ligament-specific protein 22", "protein_names_refseq": "PDLs22; periodontal ligament-specific protein 22; protein unc-50 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:67387)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11302735;21750661;30084848;31219806;34428180;36210013", "class_list": "", "function": "Involved in the cell surface expression of neuronal nicotinic receptors (By similarity). Binds RNA (By similarity)., [UniProtKB, UniProtKB]; Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0034394 protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQY6-1", "uniprot_id": [ { "id": "UQCC2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQY6", "type": "external" } ], "mass": 16321.0, "length": 136, "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 2", "gene_name": "Uqcc2", "organism": "Mouse", "refseq_name": "ubiquinol-cytochrome c reductase complex assembly factor 2 isoform 1", "refseq_ac": [ { "id": "NP_080339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080339", "type": "external" } ], "gene_names_uniprotkb": "Uqcc2; 2900010M23Rik; Mnf1", "gene_names_refseq": "2900010M23Rik; Cbp6; M19; Mnf1; Uqcc2", "protein_names_uniprotkb": "Ubiquinol-cytochrome c reductase complex assembly factor 2; Mitochondrial nucleoid factor 1; Mitochondrial protein M19", "protein_names_refseq": "mitochondrial nucleoid factor 1; mitochondrial protein M19; ubiquinol-cytochrome c reductase complex assembly factor 2 isoform 1", "tax_id": 10090, "disease": "mitochondrial complex III deficiency nuclear type 7 (Disease Ontology:DOID:0080116)", "pathway": " (mmu:67267)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19643811;21750661;22363741;35977508", "class_list": "", "function": "M19 associates with the nucleoid and likely regulates the organization and metabolism of mtDNA., [RefSeq, PubMed]; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability., [UniProtKB, UniProtKB, PubMed]; The function of M19, a novel mitochondrial nucleoid protein, is characterized in muscle and pancreatic beta-cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0002082 regulation of oxidative phosphorylation;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0070131 positive regulation of mitochondrial translation;GO:2001014 regulation of skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9CQY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ56-1", "uniprot_id": [ { "id": "USE1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ56", "type": "external" } ], "mass": 30594.0, "length": 270, "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "organism": "Mouse", "refseq_name": "vesicle transport protein USE1 isoform 3", "refseq_ac": [ { "id": "NP_001139252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139252", "type": "external" } ], "gene_names_uniprotkb": "Use1; Use1l", "gene_names_refseq": "2010315L10Rik; 5730403H22Rik; D12; Ed2; Q-snare; Use1; p31", "protein_names_uniprotkb": "Vesicle transport protein USE1; Protein D12; USE1-like protein", "protein_names_refseq": "USE1-like protein; embryonic development factor 2; vesicle transport protein USE1 isoform 3; vesicle transport protein USE1", "tax_id": 10090, "disease": "", "pathway": " (mmu:67023); (R-MMU-6811434)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19188447;19710423;21750661;23499007;25184340;34428180", "class_list": "", "function": "Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis., [RefSeq, PubMed]; Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site. Publication Status: Online-Only, [RefSeq, PubMed]; P31 is an essential molecule involved in the maintenance of endoplasmic reticulum (ER) morphology and that its deficiency leads to ER stress-induced apoptosis., [RefSeq, PubMed]; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB]; Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TUK0;Q80V73;Q99MB6", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030137 COPI-coated vesicle;GO:0031201 SNARE complex", "go_biological_process": "GO:0060628 regulation of ER to Golgi vesicle-mediated transport;GO:0071786 endoplasmic reticulum tubular network organization;GO:0015031 protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9CQ56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91W90-1", "uniprot_id": [ { "id": "TXND5_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91W90", "type": "external" } ], "mass": 46415.0, "length": 417, "protein_name": "Thioredoxin domain-containing protein 5", "gene_name": "Txndc5", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001276527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276527", "type": "external" } ], "gene_names_uniprotkb": "Txndc5; Tlp46", "gene_names_refseq": "ERp46; PC-TRP; Txndc5", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 5; 1.8.4.-; 5.3.4.1; ER protein 46; ERp46; Endoplasmic reticulum resident protein 46; PC-TRP; Plasma cell-specific thioredoxin-related protein; Thioredoxin-like protein p46", "protein_names_refseq": "ER protein 46; endoplasmic reticulum protein ERp46; endoplasmic reticulum resident protein 46; plasma cell-specific thioredoxin-related protein; thioredoxin domain-containing protein 5 isoform 2; thioredoxin domain-containing protein 5; thioredoxin-like protein p46", "tax_id": 10090, "disease": "", "pathway": " (mmu:105245); (R-MMU-432720); (R-MMU-432722); (R-MMU-6798695)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12930873;14971039;21750661;25428506;31219806;33725478;34428180;35984892;37898391", "class_list": "", "function": "Both ERp19 and ERp46 and their respective mRNAs are highly expressed in the liver as compared with other tissues, [RefSeq, PubMed]; PC-TRP was expressed at high levels in all plasma cells isolated from bone marrow or lamina propria., [RefSeq, PubMed]; Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins (PubMed:12930873, PubMed:14971039). Can reduce insulin disulfide bonds (PubMed:14971039)., [UniProtKB, PubMed, PubMed]; Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1I6", "ec_number_list": [ { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.22", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.21.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.76", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" } ], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91W90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16374-1", "uniprot_id": [ { "id": "ZFP60_MOUSE", "url": "https://www.uniprot.org/uniprot/P16374", "type": "external" } ], "mass": 82274.0, "length": 707, "protein_name": "Zinc finger protein 60", "gene_name": "Zfp60", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp60; Mfg3", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 60; Zfp-60; Zinc finger protein Mfg-3", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "21750661;2512579;25605945;8674531", "class_list": "", "function": "May have a role during differentiation processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61135", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16374-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9L4-1", "uniprot_id": [ { "id": "UBP49_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P9L4", "type": "external" } ], "mass": 78272.0, "length": 685, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 49", "gene_name": "Usp49", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 49", "refseq_ac": [ { "id": "NP_940813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940813", "type": "external" } ], "gene_names_uniprotkb": "Usp49", "gene_names_refseq": "C330046L10Rik; Gm545; Usp49", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 49; 3.4.19.12; Deubiquitinating enzyme 49; Ubiquitin thioesterase 49; Ubiquitin-specific-processing protease 49", "protein_names_refseq": "deubiquitinating enzyme 49; ubiquitin carboxyl-terminal hydrolase 49; ubiquitin thioesterase 49; ubiquitin thiolesterase 49; ubiquitin-specific-processing protease 49", "tax_id": 10090, "disease": "", "pathway": " (mmu:224836)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;30943264", "class_list": "", "function": "Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. Negatively regulates cellular antiviral responses via deconjugating 'Lys-63'-linked ubiquitination of STING1., [UniProtKB, UniProtKB]; Loss of Usp49 is associated with increased resistance to lethal HSV-1 infection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0140936 histone H2B deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P9L4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C0R0-1", "uniprot_id": [ { "id": "UBP37_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C0R0", "type": "external" } ], "mass": 110063.0, "length": 979, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 37", "gene_name": "Usp37", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 37 isoform 2", "refseq_ac": [ { "id": "NP_001297591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297591", "type": "external" } ], "gene_names_uniprotkb": "Usp37; Kiaa1594", "gene_names_refseq": "4932415L06Rik; C330008N13Rik; Usp37", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 37; 3.4.19.12; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37", "protein_names_refseq": "deubiquitinating enzyme 37; ubiquitin carboxyl-terminal hydrolase 37 isoform 2; ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific protease 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37", "tax_id": 10090, "disease": "", "pathway": " (mmu:319651); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "21183079;21750661;25428506;30084848;31219806;34428180;35820727;36029179", "class_list": "", "function": "Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1. Also plays an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability. Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM. Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM. Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI. Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination., [UniProtKB, UniProtKB]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RT12;Q69ZF6;Q8BZE6", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0051301 cell division;GO:0031647 regulation of protein stability;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8C0R0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N9-1", "uniprot_id": [ { "id": "UN13B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z1N9", "type": "external" } ], "mass": 181813.0, "length": 1602, "protein_name": "Protein unc-13 homolog B", "gene_name": "Unc13b", "organism": "Mouse", "refseq_name": "protein unc-13 homolog B isoform 2", "refseq_ac": [ { "id": "NP_001074882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074882", "type": "external" } ], "gene_names_uniprotkb": "Unc13b; Unc13a", "gene_names_refseq": "Munc13-1; Munc13-2; Unc13a; Unc13b; Unc13h1; Unc13h2", "protein_names_uniprotkb": "Protein unc-13 homolog B; Munc13-2; munc13", "protein_names_refseq": "UNC-13 homolog 1; munc13; protein unc-13 homolog B isoform 2; protein unc-13 homolog B; unc13 homolog 1", "tax_id": 10090, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (mmu:22249); (R-MMU-181429); (R-MMU-181430); (R-MMU-210500); (R-MMU-212676); (R-MMU-264642)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "12070347;15330860;21750661;23229896;30084848;31599954;34428180;38758791", "class_list": "", "function": "Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release., [RefSeq, PubMed]; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AG43;B2RXT0;B2RXY6;Q6BCX2", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0090382 phagosome maturation;GO:0007528 neuromuscular junction development;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z1N9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64435-1", "uniprot_id": [ { "id": "UD16_MOUSE", "url": "https://www.uniprot.org/uniprot/Q64435", "type": "external" } ], "mass": 60439.0, "length": 531, "protein_name": "UDP-glucuronosyltransferase 1A6", "gene_name": "Ugt1a6a; Ugt1a6; Ugt1a7c", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 1A6 precursor", "refseq_ac": [ { "id": "NP_659545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659545", "type": "external" } ], "gene_names_uniprotkb": "Ugt1a6a; Ugt1a6; Ugt1a7c; Ugt1a6a; Ugt1a7; Ugt1", "gene_names_refseq": "UDPGT 1-6; UDPGT; UGT1-06; UGT1.6; Ugt1a6a; Ugt1a6; Ugt1a7", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1A6; 2.4.1.17; Phenol UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-6; UDPGT 1-6; UGP1A1; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A7", "protein_names_refseq": "UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1A6 precursor; UDP-glucuronosyltransferase 1A6; phenol UDP-glucuronosyltransferase", "tax_id": 10090, "disease": "hepatitis B (Disease Ontology:DOID:2043); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:94284); (R-MMU-156588); (R-MMU-9749641); (R-MMU-9753281)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "14672974;21750661;23089803;30562058;34428180;36210013;37453647;7677729;8068691", "class_list": "glycogene;glycosyltransferase", "function": "The difference in expression levels between Ugt1a6a and Ugt1a6b in the hippocampus led us to speculate that Ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain., [RefSeq, PubMed]; This study provides evidence that UGT1A6A, acting on the serotonin pathway, regulates glucose induced insulin secretion under both normal and pathological conditions., [RefSeq, PubMed]; UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body (PubMed:8068691). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:8068691). Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE (By similarity). Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (PubMed:8068691). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 67, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70692;Q62580;Q6XL47", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0016125 sterol metabolic process;GO:0071385 cellular response to glucocorticoid stimulus;GO:0051552 flavone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q64435-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D572-1", "uniprot_id": [ { "id": "UBX11_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D572", "type": "external" } ], "mass": 54875.0, "length": 484, "protein_name": "UBX domain-containing protein 11", "gene_name": "Ubxn11", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 11", "refseq_ac": [ { "id": "NP_080533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080533", "type": "external" } ], "gene_names_uniprotkb": "Ubxn11; D4Bwg1540e; Soc; Ubxd5", "gene_names_refseq": "4930506L07Rik; D4Bwg1540e; Soci; Soc; Ubxd5; Ubxn11", "protein_names_uniprotkb": "UBX domain-containing protein 11; Socius; UBX domain-containing protein 5", "protein_names_refseq": "UBX domain containing 5; UBX domain-containing protein 11; UBX domain-containing protein 5; socius", "tax_id": 10090, "disease": "", "pathway": " (mmu:67586); (R-MMU-9696264); (R-MMU-9696270); (R-MMU-9696273)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11940653;21183079;21750661", "class_list": "", "function": "May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C843;Q8VCP5;Q9CWP0", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D572-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D075-1", "uniprot_id": [ { "id": "TM10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D075", "type": "external" } ], "mass": 36377.0, "length": 318, "protein_name": "tRNA methyltransferase 10 homolog B", "gene_name": "Trmt10b", "organism": "Mouse", "refseq_name": "tRNA methyltransferase 10 homolog B isoform a", "refseq_ac": [ { "id": "NP_081542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081542", "type": "external" } ], "gene_names_uniprotkb": "Trmt10b; Rg9mtd3", "gene_names_refseq": "2610042J10Rik; Rg9mtd3; Rnmtd3; Trmt10b", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog B; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 3; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B; tRNA methyltransferase 10 homolog B isoform a; tRNA methyltransferase 10 homolog B", "tax_id": 10090, "disease": "", "pathway": " (mmu:69934)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2AKB5;A2AKB6;Q8VCR1", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane;GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D075-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68037-1", "uniprot_id": [ { "id": "UB2L3_MOUSE", "url": "https://www.uniprot.org/uniprot/P68037", "type": "external" } ], "mass": 17862.0, "length": 154, "protein_name": "Ubiquitin-conjugating enzyme E2 L3", "gene_name": "Ube2l3", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 L3 isoform 1", "refseq_ac": [ { "id": "NP_033482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033482", "type": "external" } ], "gene_names_uniprotkb": "Ube2l3; Ubce7", "gene_names_refseq": "UbcM4; Ubce7; Ube2l3", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 L3; 2.3.2.23; E2 ubiquitin-conjugating enzyme L3; UbcM4; Ubiquitin carrier protein L3; Ubiquitin-protein ligase L3", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme L3; ubiquitin carrier protein L3; ubiquitin-conjugating enzyme 7; ubiquitin-conjugating enzyme E2 L3 isoform 1; ubiquitin-protein ligase L3", "tax_id": 10090, "disease": "", "pathway": " (mmu:22195); (R-MMU-5205685); (R-MMU-5357905); (R-MMU-5675482); (R-MMU-8866652); (R-MMU-8866654); (R-MMU-983168)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "21750661;22645316;25153642;25632008;26495903;26740625;28135057;28528544;34440743;36288343;37474493;37507081;8563171;8901595", "class_list": "", "function": "IL-1beta turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates ubiquitination by the CUL9-RBX1 complex (By similarity). In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51966;P70653;Q9HAV1", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008283 cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P68037-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921L3-1", "uniprot_id": [ { "id": "TMCO1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q921L3", "type": "external" } ], "mass": 21175.0, "length": 188, "protein_name": "Calcium load-activated calcium channel", "gene_name": "Tmco1", "organism": "Mouse", "refseq_name": "calcium load-activated calcium channel", "refseq_ac": [ { "id": "NP_001034572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034572", "type": "external" } ], "gene_names_uniprotkb": "Tmco1", "gene_names_refseq": "1190006A08Rik; 4930403O06Rik; ESTM39; Tmco1", "protein_names_uniprotkb": "Calcium load-activated calcium channel; CLAC channel; GEL complex subunit TMCO1; Transmembrane and coiled-coil domain-containing protein 1", "protein_names_refseq": "CLAC channel; GEL complex subunit TMCO1; calcium load-activated calcium channel; transmembrane and coiled-coil domain-containing protein 1", "tax_id": 10090, "disease": "craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome (Disease Ontology:DOID:0081072); craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1 (Disease Ontology:DOID:0081124)", "pathway": " (mmu:68944)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21750661;27212239;29467381;30929916;30962442;34428180;35927240;40997131", "class_list": "", "function": "An essential role of TMCO1 in osteogenesis mediated by local Ca(2+)/CaMKII signaling in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Ca(2+) homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum (ER) calcium-selective channel preventing intracellular Ca2(+) stores from overfilling and maintaining calcium homeostasis in the ER. In response to endoplasmic reticulum (ER) Ca2(+) overloading, assembles into a homotetramer, forming a functional calcium-selective channel facilitating Ca2(+) release (PubMed:27212239, PubMed:29467381, PubMed:30962442). Mediates ER Ca2(+) homeostasis in osteoblasts and plays a key role in bone formation, via the CaMKII-HDAC4-RUNX2 signaling axis (PubMed:30962442). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TMCO1 provides a protective mechanism to prevent overfilling of endoplasmic reticulum stores with Ca(2+) ions, [RefSeq, PubMed]; The role of TMCO1 in regulating lipid-metabolism and mitochondrial function., [RefSeq, PubMed]; Tmco1 is required for ovarian follicle development, which is closely linked with the role of TMCO1 in maintaining normal ER Ca2+ store in GCs. Deletion of Tmco1 can cause ER Ca2+ overloaded in GCs followed by ER stress and oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TS11", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001503 ossification;GO:0070588 calcium ion transmembrane transport;GO:0006983 ER overload response;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q921L3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2Q2-1", "uniprot_id": [ { "id": "TRM44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2Q2", "type": "external" } ], "mass": 79836.0, "length": 713, "protein_name": "Probable tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "Trmt44", "organism": "Mouse", "refseq_name": "probable tRNA (uracil-O(2)-)-methyltransferase", "refseq_ac": [ { "id": "NP_084484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084484", "type": "external" } ], "gene_names_uniprotkb": "Trmt44; Mettl19", "gene_names_refseq": "2310079F23Rik; Mettl19; Trmt44", "protein_names_uniprotkb": "Probable tRNA (uracil-O(2)-)-methyltransferase; 2.1.1.211; Methyltransferase-like protein 19", "protein_names_refseq": "methyltransferase-like protein 19; probable tRNA (uracil-O(2)-)-methyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:78890)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase., [UniProtKB, UniProtKB]; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MCV4;Q3V1K3", "ec_number_list": [ { "id": "2.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.211", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016300 tRNA (uridine) methyltransferase activity;GO:0141101 tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MU1-1", "uniprot_id": [ { "id": "TPRA1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99MU1", "type": "external" } ], "mass": 40578.0, "length": 369, "protein_name": "Transmembrane protein adipocyte-associated 1", "gene_name": "Tpra1", "organism": "Mouse", "refseq_name": "transmembrane protein adipocyte-associated 1 isoform 1", "refseq_ac": [ { "id": "NP_036036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036036", "type": "external" } ], "gene_names_uniprotkb": "Tpra1; Gpr175; Tpra40", "gene_names_refseq": "40kDa; Gpr175; Tpra1; Tpra40", "protein_names_uniprotkb": "Transmembrane protein adipocyte-associated 1; Integral membrane protein GPR175; TPRA40; Transmembrane domain protein of 40 kDa regulated in adipocytes", "protein_names_refseq": "G protein-coupled receptor 175; integral membrane protein GPR175; transmembrane domain protein of 40 kDa regulated in adipocytes; transmembrane domain protein regulated in adipocytes 40 kDa; transmembrane protein adipocyte-associated 1 isoform 1; transmembrane protein adipocyte-associated 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:24100)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10342878;12679517;18459117;21750661;31219806;34428180", "class_list": "", "function": "The functional plasma membrane transport of TPRA40 that regulates cell division of mouse embryos is mediated by NA14., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q80UD9;Q8C240;Q91Z36;Q9Z112", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0040016 embryonic cleavage;GO:1901991 negative regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99MU1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99LG2-1", "uniprot_id": [ { "id": "TNPO2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99LG2", "type": "external" } ], "mass": 100456.0, "length": 887, "protein_name": "Transportin-2", "gene_name": "Tnpo2", "organism": "Mouse", "refseq_name": "transportin-2 isoform 1", "refseq_ac": [ { "id": "NP_001116315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116315", "type": "external" } ], "gene_names_uniprotkb": "Tnpo2", "gene_names_refseq": "1110034O24Rik; IPO3; Knpb2b; Kpnb2b; TRN2; Tnpo2", "protein_names_uniprotkb": "Transportin-2; Karyopherin beta-2b", "protein_names_refseq": "karyopherin (importin) beta 2b; karyopherin beta-2b; transportin-2 isoform 1; transportin-2", "tax_id": 10090, "disease": "intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies (Disease Ontology:DOID:0081262)", "pathway": " (mmu:212999)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17475777;21750661;28777795;33300544", "class_list": "", "function": "Early in muscle differentiation, HuR is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import., [RefSeq, PubMed]; Essential for Hedgehog pathway activation; mediates ciliary translocation of Gli proteins Publication Status: Online-Only, [RefSeq, PubMed]; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C0U9", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051148 negative regulation of muscle cell differentiation;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99LG2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUS6-1", "uniprot_id": [ { "id": "TRIM1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QUS6", "type": "external" } ], "mass": 79774.0, "length": 705, "protein_name": "Probable E3 ubiquitin-protein ligase MID2", "gene_name": "Mid2", "organism": "Mouse", "refseq_name": "probable E3 ubiquitin-protein ligase MID2 isoform 3", "refseq_ac": [ { "id": "NP_035975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035975", "type": "external" } ], "gene_names_uniprotkb": "Mid2; Fxy2; Trim1", "gene_names_refseq": "FXY2; Mid2; Trim1", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase MID2; 2.3.2.27; Midline defect 2; Midline-2; RING-type E3 ubiquitin transferase MID2; Tripartite motif-containing protein 1", "protein_names_refseq": "RING-type E3 ubiquitin transferase MID2; midline defect 2; probable E3 ubiquitin-protein ligase MID2 isoform 3; probable E3 ubiquitin-protein ligase MID2; tripartite motif-containing protein 1", "tax_id": 10090, "disease": "non-syndromic X-linked intellectual disability 101 (Disease Ontology:DOID:0112048)", "pathway": " (mmu:23947)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;10400986;10644436;21750661;25924778", "class_list": "", "function": "Both MID1 and MID2 play a central role in the regulation of granule exocytosis and that functional redundancy exists between MID1 and MID2 in cytotoxic T cells, [RefSeq, PubMed]; E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9792, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QUS6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JG7-1", "uniprot_id": [ { "id": "TNIP2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99JG7", "type": "external" } ], "mass": 49094.0, "length": 430, "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "Tnip2", "organism": "Mouse", "refseq_name": "TNFAIP3-interacting protein 2", "refseq_ac": [ { "id": "NP_620703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620703", "type": "external" } ], "gene_names_uniprotkb": "Tnip2; Abin2", "gene_names_refseq": "1810020H16Rik; ABIN-2; Tnip2", "protein_names_uniprotkb": "TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2", "protein_names_refseq": "A20 binding inhibitor of NF-kappaB activation-2; A20-binding inhibitor of NF-kappa-B activation 2; TNFAIP3-interacting protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:231130); (R-MMU-5684264); (R-MMU-5689896)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "11390377;15169888;16480954;16633345;21750661;29176547;30337469;31219806;34428180;36210013", "class_list": "", "function": "ABIN-2 acts to positively regulate the Erk signaling potential by stabilizing TPL-2., [RefSeq, PubMed]; ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration, [RefSeq, PubMed]; Authors found that TNIP2 was correlated with the activation of NF-kappaB in cerulein-stimulated AR42J cells, and TNIP2 over-expression inhibited the inflammatory response caused by cerulein. Moreover, results suggest that TNIP2 over-expression relieved the cerulein-triggered inflammatory response and AP-induced myocardial injury in mice. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes., [UniProtKB, PubMed, PubMed]; Optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105, [RefSeq, PubMed]; These results identify ABIN-2 as a novel negative regulator of allergic airway responses and importantly indicate that TPL-2 inhibitors would not have unwanted allergic comorbidities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TVF3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0070498 interleukin-1-mediated signaling pathway;GO:0023035 CD40 signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99JG7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91WU4-1", "uniprot_id": [ { "id": "TMCO4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91WU4", "type": "external" } ], "mass": 67945.0, "length": 631, "protein_name": "Transmembrane and coiled-coil domain-containing protein 4", "gene_name": "Tmco4", "organism": "Mouse", "refseq_name": "transmembrane and coiled-coil domain-containing protein 4", "refseq_ac": [ { "id": "NP_001292352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292352", "type": "external" } ], "gene_names_uniprotkb": "Tmco4", "gene_names_refseq": "4632413C14Rik; Tmco4", "protein_names_uniprotkb": "Transmembrane and coiled-coil domain-containing protein 4", "protein_names_refseq": "novel DUF726 domain containing protein; transmembrane and coiled-coil domain-containing protein 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:77056)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;31219806", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BIX8;Q9D675", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91WU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q922Z1-1", "uniprot_id": [ { "id": "LDAF1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q922Z1", "type": "external" } ], "mass": 17643.0, "length": 161, "protein_name": "Lipid droplet assembly factor 1", "gene_name": "Ldaf1", "organism": "Mouse", "refseq_name": "lipid droplet assembly factor 1 isoform 1", "refseq_ac": [ { "id": "NP_663561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663561", "type": "external" } ], "gene_names_uniprotkb": "Ldaf1; Tmem159", "gene_names_refseq": "8430420C20Rik; Ldaf1; Tmem159", "protein_names_uniprotkb": "Lipid droplet assembly factor 1; Promethin; Transmembrane protein 159", "protein_names_refseq": "lipid droplet assembly factor 1 isoform 1; promethin; transmembrane protein 159", "tax_id": 10090, "disease": "", "pathway": " (mmu:233806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15589683", "class_list": "", "function": "Plays an important role in the formation of lipid droplets during the differentiation and maturation of adipocytes. Together with seipin (BSCL2), defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8C5E0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q922Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PN3-1", "uniprot_id": [ { "id": "TRI26_MOUSE", "url": "https://www.uniprot.org/uniprot/Q99PN3", "type": "external" } ], "mass": 62809.0, "length": 545, "protein_name": "Tripartite motif-containing protein 26", "gene_name": "Trim26", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 26", "refseq_ac": [ { "id": "NP_001020770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020770", "type": "external" } ], "gene_names_uniprotkb": "Trim26; Znf173", "gene_names_refseq": "Trim26; Zfp1736; Zfp173", "protein_names_uniprotkb": "Tripartite motif-containing protein 26; 2.3.2.27; Zinc finger protein 173", "protein_names_refseq": "tripartite motif protein 26; tripartite motif protein TRIM26; tripartite motif-containing protein 26; zinc finger protein 173", "tax_id": 10090, "disease": "", "pathway": " (mmu:22670)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "20173027;21750661;25428506;27802388;29203640;30084848;30779550;31599954;33869196;34017102;38166150;38926362", "class_list": "", "function": "E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (PubMed:33869196)., [UniProtKB, UniProtKB, PubMed, PubMed]; Sustained exposure of cells to TGF-beta resulted in recovery from proliferative arrest in association with amplification of the Myc proto-oncogene, with MYC inhibiting TRIM26 induction by TGF-beta. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection. Publication Status: Online-Only, [RefSeq, PubMed]; TRIM26 deficiency enhancing liver regeneration through macrophage polarization and beta-catenin pathway activation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8JJ55;Q8C9E9;Q8JZT7;Q99PN2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q99PN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQG6-1", "uniprot_id": [ { "id": "TM147_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQG6", "type": "external" } ], "mass": 25335.0, "length": 224, "protein_name": "BOS complex subunit TMEM147", "gene_name": "Tmem147", "organism": "Mouse", "refseq_name": "BOS complex subunit TMEM147", "refseq_ac": [ { "id": "NP_081491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081491", "type": "external" } ], "gene_names_uniprotkb": "Tmem147", "gene_names_refseq": "2010004E11Rik; 5033425B17Rik; Nifie14; Tmem147", "protein_names_uniprotkb": "BOS complex subunit TMEM147; Transmembrane protein 147", "protein_names_refseq": "BOS complex subunit TMEM147; seven transmembrane domain protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:69804)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21056967;21750661;34428180", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CI89;Q9D8F0", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0036228 protein localization to nuclear inner membrane;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CQG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CXL1-1", "uniprot_id": [ { "id": "TM50A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CXL1", "type": "external" } ], "mass": 17495.0, "length": 157, "protein_name": "Transmembrane protein 50A", "gene_name": "Tmem50a", "organism": "Mouse", "refseq_name": "transmembrane protein 50A isoform a", "refseq_ac": [ { "id": "NP_082211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082211", "type": "external" } ], "gene_names_uniprotkb": "Tmem50a; Smp1", "gene_names_refseq": "3200001F09Rik; CAM; Smp1; Tmem50a", "protein_names_uniprotkb": "Transmembrane protein 50A; Small membrane protein 1", "protein_names_refseq": "small membrane protein 1; transmembrane protein 50A isoform a", "tax_id": 10090, "disease": "", "pathway": " (mmu:71817)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12459264;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0097386 glial cell projection", "go_biological_process": "GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9CXL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D1D4-1", "uniprot_id": [ { "id": "TMEDA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D1D4", "type": "external" } ], "mass": 24911.0, "length": 219, "protein_name": "Transmembrane emp24 domain-containing protein 10", "gene_name": "Tmed10", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 10 precursor", "refseq_ac": [ { "id": "NP_081051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081051", "type": "external" } ], "gene_names_uniprotkb": "Tmed10; Tmp21", "gene_names_refseq": "1110014C03Rik; Tmed10; Tmp21; p23; p24delta1", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 10; 21 kDa transmembrane-trafficking protein; Protein Tmed10; Transmembrane protein Tmp21; p24 family protein delta-1; p24delta1", "protein_names_refseq": "21 kDa transmembrane-trafficking protein; p24 family protein delta-1; transmembrane emp24 domain-containing protein 10 precursor; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:68581); (R-MMU-204005); (R-MMU-5694530); (R-MMU-6807878); (R-MMU-6811434)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10.1101/2023.09.13.557529;10660306;17101722;21750661;22645316;25428506;29874591;32272059;34428180;36244749;37453647;37931110;38663774", "class_list": "", "function": "Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis., [RefSeq, PubMed]; Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER (By similarity). Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) (By similarity). Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus. Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization. In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC. Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9. Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation., [RefSeq, PubMed]; Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3U7I7;Q6P227;Q922U8", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045055 regulated exocytosis;GO:0050714 positive regulation of protein secretion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9D1D4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D6G5-1", "uniprot_id": [ { "id": "TM138_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D6G5", "type": "external" } ], "mass": 19150.0, "length": 162, "protein_name": "Transmembrane protein 138", "gene_name": "Tmem138", "organism": "Mouse", "refseq_name": "transmembrane protein 138 isoform 2", "refseq_ac": [ { "id": "NP_001289147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289147", "type": "external" } ], "gene_names_uniprotkb": "Tmem138", "gene_names_refseq": "1700113I01Rik; 2900055D14Rik; Tmem138", "protein_names_uniprotkb": "Transmembrane protein 138", "protein_names_refseq": "transmembrane protein 138 isoform 2", "tax_id": 10090, "disease": "Joubert syndrome 16 (Disease Ontology:DOID:0110985)", "pathway": " (mmu:72982)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;34428180", "class_list": "", "function": "Required for ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9D9A8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9D6G5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DBY4-1", "uniprot_id": [ { "id": "TRIL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DBY4", "type": "external" } ], "mass": 88810.0, "length": 809, "protein_name": "TLR4 interactor with leucine rich repeats", "gene_name": "Tril", "organism": "Mouse", "refseq_name": "TLR4 interactor with leucine rich repeats precursor", "refseq_ac": [ { "id": "NP_080093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080093", "type": "external" } ], "gene_names_uniprotkb": "Tril; Kiaa0644", "gene_names_refseq": "1200009O22Rik; Tril; mKIAA0644", "protein_names_uniprotkb": "TLR4 interactor with leucine rich repeats; Leucine-rich repeat-containing protein KIAA0644", "protein_names_refseq": "TLR4 interactor with leucine rich repeats precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:66873)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;19710467;25015823;25428506;27802388;30899004;34504172", "class_list": "", "function": "Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion (By similarity)., [UniProtKB]; TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; TRIL is a novel component of the TLR4 complex which may have particular relevance for the functional role of TLR4 in the brain, [RefSeq, PubMed]; These data uncover TRIL as a mediator of innate immune responses within the brain, where it enhances neuronal cytokine responses to infection., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80TV0;Q8BKM5", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0002718 regulation of cytokine production involved in immune response;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0034142 toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9DBY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP64-1", "uniprot_id": [ { "id": "TNMD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP64", "type": "external" } ], "mass": 37047.0, "length": 317, "protein_name": "Tenomodulin", "gene_name": "Tnmd", "organism": "Mouse", "refseq_name": "tenomodulin", "refseq_ac": [ { "id": "NP_071717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071717", "type": "external" } ], "gene_names_uniprotkb": "Tnmd; Chm1l", "gene_names_refseq": "1110017I01Rik; Bricd4; ChM1L; TeM; Tnmd", "protein_names_uniprotkb": "Tenomodulin; ChM1L; Chondromodulin-1-like protein; Chondromodulin-I-like protein; Myodulin; TeM; Tendin; mChM1L; mTeM", "protein_names_refseq": "chondromodulin-1-like protein; chondromodulin-I-like protein; mChM1L; mTeM; myodulin; tendin; tenomodulin", "tax_id": 10090, "disease": "", "pathway": " (mmu:64103)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;11162640;11162673;11357195;23386199", "class_list": "", "function": "May be an angiogenesis inhibitor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CET4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane", "go_biological_process": "GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0001886 endothelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EP64-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUH1-1", "uniprot_id": [ { "id": "TM115_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WUH1", "type": "external" } ], "mass": 38099.0, "length": 350, "protein_name": "Transmembrane protein 115", "gene_name": "Tmem115", "organism": "Mouse", "refseq_name": "transmembrane protein 115", "refseq_ac": [ { "id": "NP_062678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062678", "type": "external" } ], "gene_names_uniprotkb": "Tmem115; Pl6", "gene_names_refseq": "Pl6; Pp6; Tmem115", "protein_names_uniprotkb": "Transmembrane protein 115; Protein PL6 homolog", "protein_names_refseq": "placental protein 6; protein PL6 homolog; transmembrane protein 115", "tax_id": 10090, "disease": "", "pathway": " (mmu:56395); (R-MMU-6807878)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17242355;19144319;24806965;34428180", "class_list": "", "function": "May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi., [UniProtKB, UniProtKB]; Results establish that TMEM115 is an integral membrane protein of the Golgi stack regulating Golgi-to-ER retrograde transport and is likely to be part of the machinery of the COG complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91VT6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08EA8-1", "uniprot_id": [ { "id": "TM213_MOUSE", "url": "https://www.uniprot.org/uniprot/Q08EA8", "type": "external" } ], "mass": 12442.0, "length": 116, "protein_name": "Transmembrane protein 213", "gene_name": "Tmem213", "organism": "Mouse", "refseq_name": "transmembrane protein 213", "refseq_ac": [ { "id": "NP_084197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084197", "type": "external" } ], "gene_names_uniprotkb": "Tmem213", "gene_names_refseq": "D630002J15Rik; Tmem213", "protein_names_uniprotkb": "Transmembrane protein 213", "protein_names_refseq": "transmembrane protein 213", "tax_id": 10090, "disease": "", "pathway": " (mmu:77522)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9D1U9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08EA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R0I4-1", "uniprot_id": [ { "id": "TM2D2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R0I4", "type": "external" } ], "mass": 22853.0, "length": 213, "protein_name": "TM2 domain-containing protein 2", "gene_name": "Tm2d2", "organism": "Mouse", "refseq_name": "TM2 domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_081470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081470", "type": "external" } ], "gene_names_uniprotkb": "Tm2d2", "gene_names_refseq": "2410018G23Rik; Blp1; Tm2d2", "protein_names_uniprotkb": "TM2 domain-containing protein 2", "protein_names_refseq": "BBP-like protein 1; TM2 domain-containing protein 2 precursor; TM2 domain-containing protein 2", "tax_id": 10090, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (mmu:69742)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21750661", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BJJ1;Q9CWL9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R0I4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZE7-1", "uniprot_id": [ { "id": "TSNAX_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZE7", "type": "external" } ], "mass": 32926.0, "length": 290, "protein_name": "Translin-associated protein X", "gene_name": "Tsnax", "organism": "Mouse", "refseq_name": "translin-associated protein X", "refseq_ac": [ { "id": "NP_058605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058605", "type": "external" } ], "gene_names_uniprotkb": "Tsnax; Trax", "gene_names_refseq": "Trax; Tsnax", "protein_names_uniprotkb": "Translin-associated protein X; Translin-associated factor X", "protein_names_refseq": "translin-associated protein X", "tax_id": 10090, "disease": "", "pathway": " (mmu:53424); (R-MMU-426486)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10790540;15314092;21750661;31219806;31625778;32408014;33172471;34428180;36210013;36517806", "class_list": "", "function": "Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity)., [UniProtKB]; Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Deletion of the TN/TX complex selectively increases aortic miR-181b and prevents increased vascular stiffness caused by ingestion of high-salt water., [RefSeq, PubMed]; Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion., [RefSeq, PubMed]; Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity. Erratum:[Mol Brain. 2021 Mar 5;14(1):48. doi: 10.1186/s13041-021-00761-2. PMID: 33673835] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UJR2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0043565 sequence-specific DNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QZE7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XE8-1", "uniprot_id": [ { "id": "TM205_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91XE8", "type": "external" } ], "mass": 21180.0, "length": 189, "protein_name": "Transmembrane protein 205", "gene_name": "Tmem205", "organism": "Mouse", "refseq_name": "transmembrane protein 205", "refseq_ac": [ { "id": "NP_001240797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240797", "type": "external" } ], "gene_names_uniprotkb": "Tmem205", "gene_names_refseq": "Tmem205", "protein_names_uniprotkb": "Transmembrane protein 205", "protein_names_refseq": "transmembrane protein 205", "tax_id": 10090, "disease": "", "pathway": " (mmu:235043)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10679242;21750661;31219806;34428180;37453647", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JME6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91XE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61089-1", "uniprot_id": [ { "id": "UBE2N_MOUSE", "url": "https://www.uniprot.org/uniprot/P61089", "type": "external" } ], "mass": 17138.0, "length": 152, "protein_name": "Ubiquitin-conjugating enzyme E2 N", "gene_name": "Ube2n", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 N", "refseq_ac": [ { "id": "NP_542127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542127", "type": "external" } ], "gene_names_uniprotkb": "Ube2n; Blu", "gene_names_refseq": "1500026J17Rik; UBC13; Ube2n", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 N; 2.3.2.23; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme N; bendless-like ubiquitin-conjugating enzyme; ubiquitin carrier protein N; ubiquitin-conjugating enzyme E2 N; ubiquitin-protein ligase N", "tax_id": 10090, "disease": "", "pathway": " (mmu:93765); (R-MMU-1169408); (R-MMU-168638); (R-MMU-202424); (R-MMU-2871837); (R-MMU-445989); (R-MMU-450302); (R-MMU-450321); (R-MMU-5205685); (R-MMU-5607764); (R-MMU-5693565); (R-MMU-5693571); (R-MMU-5693607); (R-MMU-5696395); (R-MMU-69473); (R-MMU-8866654); (R-MMU-9020702); (R-MMU-937039); (R-MMU-937041); (R-MMU-9646399); (R-MMU-975144); (R-MMU-983168)", "pathway_count": 22, "publication_count": 14, "publication_id_list": "12039045;16307917;21750661;22424771;28039360;28123943;28469175;29499132;34428180;36288343;37453647;37507081;37632103;39015037", "class_list": "", "function": "Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13. Publication Status: Online-Only, [RefSeq, PubMed]; Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta., [RefSeq, PubMed]; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:22424771, PubMed:28039360). This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:22424771). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q16781;Q3TSL6;Q6ZWZ0;Q9DAJ6", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding;GO:0097027 ubiquitin-protein transferase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045739 positive regulation of DNA repair;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P61089-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2APC3-1", "uniprot_id": [ { "id": "TTLL9_MOUSE", "url": "https://www.uniprot.org/uniprot/A2APC3", "type": "external" } ], "mass": 54107.0, "length": 461, "protein_name": "Probable tubulin polyglutamylase TTLL9", "gene_name": "Ttll9", "organism": "Mouse", "refseq_name": "probable tubulin polyglutamylase TTLL9 isoform 1", "refseq_ac": [ { "id": "NP_001077087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077087", "type": "external" } ], "gene_names_uniprotkb": "Ttll9", "gene_names_refseq": "1700016F23Rik; 4930509O20Rik; Ttll9", "protein_names_uniprotkb": "Probable tubulin polyglutamylase TTLL9; 6.3.2.-; Tubulin--tyrosine ligase-like protein 9", "protein_names_refseq": "probable tubulin polyglutamylase TTLL9 isoform 1; probable tubulin polyglutamylase TTLL9; putative polyglutamylase; tubulin tyrosine ligase like family 9; tubulin--tyrosine ligase-like protein 9", "tax_id": 10090, "disease": "", "pathway": " (mmu:74711); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17499049;21750661;23897886;27257088", "class_list": "", "function": "Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:27257088). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable). Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern (PubMed:27257088)., [UniProtKB, PubMed, PubMed]; Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2APC4;A2APC5;A2APC6;Q9D570", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0036064 ciliary basal body", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A2APC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25785-1", "uniprot_id": [ { "id": "TIMP2_MOUSE", "url": "https://www.uniprot.org/uniprot/P25785", "type": "external" } ], "mass": 24328.0, "length": 220, "protein_name": "Metalloproteinase inhibitor 2", "gene_name": "Timp2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Timp2; Timp-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Metalloproteinase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinases 2", "protein_names_refseq": "", "tax_id": 10090, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Huntington's disease (Disease Ontology:DOID:12858); Moyamoya disease (Disease Ontology:DOID:13099); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); preretinal fibrosis (Disease Ontology:DOID:2006); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-MMU-1592389); (R-MMU-6798695); (R-MMU-9839383)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1601312;1639268;16985004;1851244;21750661;31219806;37828378", "class_list": "", "function": "Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030426 growth cone;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0046580 negative regulation of Ras protein signal transduction;GO:0032487 regulation of Rap protein signal transduction;GO:1905049 negative regulation of metallopeptidase activity;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25785-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RVY9-1", "uniprot_id": [ { "id": "TM182_MOUSE", "url": "https://www.uniprot.org/uniprot/B2RVY9", "type": "external" } ], "mass": 25845.0, "length": 229, "protein_name": "Transmembrane protein 182", "gene_name": "Tmem182", "organism": "Mouse", "refseq_name": "transmembrane protein 182 precursor", "refseq_ac": [ { "id": "NP_001074667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074667", "type": "external" } ], "gene_names_uniprotkb": "Tmem182", "gene_names_refseq": "2310079P10Rik; Tmem182", "protein_names_uniprotkb": "Transmembrane protein 182", "protein_names_refseq": "transmembrane protein 182 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:381339)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18803820;34427057;38181918", "class_list": "", "function": "Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (PubMed:34427057). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (PubMed:34427057)., [UniProtKB, PubMed]; TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration., [RefSeq, PubMed]; The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007517 muscle organ development;GO:0045662 negative regulation of myoblast differentiation;GO:0014908 myotube differentiation involved in skeletal muscle regeneration;GO:0014906 myotube cell development involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B2RVY9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3YU32-1", "uniprot_id": [ { "id": "T13C1_MOUSE", "url": "https://www.uniprot.org/uniprot/D3YU32", "type": "external" } ], "mass": 67298.0, "length": 604, "protein_name": "Testis-expressed protein 13C-1", "gene_name": "Tex13c1", "organism": "Mouse", "refseq_name": "testis-expressed protein 13C-1", "refseq_ac": [ { "id": "NP_001182200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182200", "type": "external" } ], "gene_names_uniprotkb": "Tex13c1; Gm362", "gene_names_refseq": "Gm362; Tex13c1; Tex13c", "protein_names_uniprotkb": "Testis-expressed protein 13C-1; TEX13 family member C-1", "protein_names_refseq": "TEX13 family member C-1; testis-expressed protein 13C-1; testis-expressed protein 13C; testis-expressed sequence 13C protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:637093)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33811575", "class_list": "", "function": "Plays a role in transcriptional repression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3YU32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70281-1", "uniprot_id": [ { "id": "TPST1_MOUSE", "url": "https://www.uniprot.org/uniprot/O70281", "type": "external" } ], "mass": 42132.0, "length": 370, "protein_name": "Protein-tyrosine sulfotransferase 1", "gene_name": "Tpst1", "organism": "Mouse", "refseq_name": "protein-tyrosine sulfotransferase 1", "refseq_ac": [ { "id": "NP_001123948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123948", "type": "external" } ], "gene_names_uniprotkb": "Tpst1", "gene_names_refseq": "Tango13a; Tpst1", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase 1; 2.8.2.20; TPST-1; Tyrosylprotein sulfotransferase 1", "protein_names_refseq": "TPST-1; protein-tyrosine sulfotransferase 1; tyrosylprotein sulfotransferase 1", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (mmu:22021); (R-MMU-156584); (R-MMU-163841)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "21633705;21665277;21750661;22745813;25428506;30084848;34428180;9501187", "class_list": "glycogene", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1., [RefSeq, PubMed]; Results demonstrate the importance of protein-tyrosine sulfation for proper development of the retina and suggest different phenotypes resulting from elimination of TPST-1 or -2 may reflect differential expression patterns or levels of the enzymes., [RefSeq, PubMed]; Two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 17, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.20", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008476 protein-tyrosine sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006478 peptidyl-tyrosine sulfation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O70281-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V85-1", "uniprot_id": [ { "id": "TRI62_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80V85", "type": "external" } ], "mass": 54298.0, "length": 475, "protein_name": "E3 ubiquitin-protein ligase TRIM62", "gene_name": "Trim62", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM62 isoform 2", "refseq_ac": [ { "id": "NP_835211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835211", "type": "external" } ], "gene_names_uniprotkb": "Trim62", "gene_names_refseq": "6330414G21Rik; Dear1; Trim62", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM62; 2.3.2.27; Tripartite motif-containing protein 62", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM62 isoform 2; E3 ubiquitin-protein ligase TRIM62; RING-type E3 ubiquitin transferase TRIM62; tripartite motif-containing protein 62", "tax_id": 10090, "disease": "", "pathway": " (mmu:67525)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21750661;24890125;26488816;32703402", "class_list": "", "function": "E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (By similarity)., [UniProtKB, UniProtKB]; TRIM62 knockout protects against cerebral ischemic injury in mice by suppressing NLRP3-regulated neuroinflammation., [RefSeq, PubMed]; Trim62 loss cooperates with K-Ras mutation in tumourigenesis and metastasis in vivo, indicating that decreased levels of TRIM62 may play an important role in the evolution of lung cancer., [RefSeq, PubMed]; Ubiquitination of CARD9 by TRIM62 regulates CARD9-mediated anti-fungal immunity. Trim62-deficient mice had increased susceptibility to fungal infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046596 regulation of viral entry into host cell;GO:0032897 negative regulation of viral transcription;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0044314 protein K27-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80V85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ8-1", "uniprot_id": [ { "id": "TIM23_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WTQ8", "type": "external" } ], "mass": 21978.0, "length": 209, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim23", "gene_name": "Timm23", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Timm23; Tim23", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim23", "protein_names_refseq": "", "tax_id": 10090, "disease": "muscular atrophy (Disease Ontology:DOID:767)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "11165051;19111522;21750661;25428506;29562282", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0008320 protein transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0140494 migrasome", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix;GO:0061734 type 2 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WTQ8-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7BWT7-1", "uniprot_id": [ { "id": "TSN15_MOUSE", "url": "https://www.uniprot.org/uniprot/F7BWT7", "type": "external" } ], "mass": 33071.0, "length": 294, "protein_name": "Tetraspanin-15", "gene_name": "Tspan15", "organism": "Mouse", "refseq_name": "tetraspanin-15", "refseq_ac": [ { "id": "NP_932113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932113", "type": "external" } ], "gene_names_uniprotkb": "Tspan15", "gene_names_refseq": "1110036D12Rik; 2700063A19Rik; Tm4sf15; Tspan15", "protein_names_uniprotkb": "Tetraspanin-15; Transmembrane 4 superfamily member 15; Tspan-15", "protein_names_refseq": "tetraspanin-15; transmembrane 4 superfamily member 15; tspan-15", "tax_id": 10090, "disease": "", "pathway": " (mmu:70423)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;23035126;26668317;29520422;30463011;32111735", "class_list": "", "function": "Data show that tetraspanin15 (Tspan15) is abundantly expressed in brain, where it specifically interacts with endogenous a disintegrin and metalloproteinase 10 (ADAM10)., [RefSeq, PubMed]; Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126, PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH2 (PubMed:26668317). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C0H5X1;Q3TA07", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030054 cell junction;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0051604 protein maturation;GO:0045746 negative regulation of Notch signaling pathway;GO:0051043 regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "F7BWT7-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21126-1", "uniprot_id": [ { "id": "UBL4A_MOUSE", "url": "https://www.uniprot.org/uniprot/P21126", "type": "external" } ], "mass": 17801.0, "length": 157, "protein_name": "Ubiquitin-like protein 4A", "gene_name": "Ubl4a", "organism": "Mouse", "refseq_name": "ubiquitin-like protein 4A", "refseq_ac": [ { "id": "NP_663380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663380", "type": "external" } ], "gene_names_uniprotkb": "Ubl4a; Gdx; Ubl4", "gene_names_refseq": "DXHXS254E; DXS254Eh; DXS254E; Gdx; Ubl4a; Ubl4", "protein_names_uniprotkb": "Ubiquitin-like protein 4A; Ubiquitin-like protein GDX", "protein_names_refseq": "housekeeping protein DXS254E; ubiquitin-like 4; ubiquitin-like protein 4A; ubiquitin-like protein GDX", "tax_id": 10090, "disease": "", "pathway": " (mmu:100169864); (mmu:27643)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1973144;21750661;28528544;31002527;31219806;31451677;33211772;34428180", "class_list": "", "function": "A novel positive feedback regulation of UBL4A in innate immune response combating virus invasion by enhancing the K63-linked ubiquitination of TRAF6., [RefSeq, PubMed]; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome., [UniProtKB, UniProtKB]; These findings suggested that GdX functions as an important regulator of Th1 or Th17 and Treg cell balance during the inflammatory responses., [RefSeq, PubMed]; Ubl4A is critical for mitochondrial fusion process under nutrient deprivation stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0031647 regulation of protein stability;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P21126-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGP5-1", "uniprot_id": [ { "id": "TM127_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGP5", "type": "external" } ], "mass": 25835.0, "length": 238, "protein_name": "Transmembrane protein 127", "gene_name": "Tmem127", "organism": "Mouse", "refseq_name": "transmembrane protein 127 isoform 1", "refseq_ac": [ { "id": "NP_780354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780354", "type": "external" } ], "gene_names_uniprotkb": "Tmem127", "gene_names_refseq": "2310003P10Rik; Tmem127", "protein_names_uniprotkb": "Transmembrane protein 127", "protein_names_refseq": "transmembrane protein 127 isoform 1", "tax_id": 10090, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771)", "pathway": " (mmu:69470)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31624249;34428180", "class_list": "", "function": "Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor., [UniProtKB]; Hepatic transmembrane protein 127 (Tmem127) expression is increased in insulin-resistant states. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2ARF9;Q3TMK7", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0007032 endosome organization;GO:0032007 negative regulation of TOR signaling;GO:0032006 regulation of TOR signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGP5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT2-1", "uniprot_id": [ { "id": "TR119_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9JKT2", "type": "external" } ], "mass": 37735.0, "length": 335, "protein_name": "Taste receptor type 2 member 119", "gene_name": "Tas2r119", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 119", "refseq_ac": [ { "id": "NP_065249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065249", "type": "external" } ], "gene_names_uniprotkb": "Tas2r119; Tas2r19", "gene_names_refseq": "T2r19; Tas2r119; Tas2r19; mGR19; mt2r19", "protein_names_uniprotkb": "Taste receptor type 2 member 119; T2R119; T2R19; Taste receptor type 2 member 19", "protein_names_refseq": "T2R119; candidate taste receptor T2R19; taste receptor type 2 member 119; taste receptor type 2 member 19", "tax_id": 10090, "disease": "", "pathway": " (mmu:57254); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520;21750661", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2M2Q7", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88978-1", "uniprot_id": [ { "id": "DAA11_MOUSE", "url": "https://www.uniprot.org/uniprot/O88978", "type": "external" } ], "mass": 55049.0, "length": 473, "protein_name": "Dynein axonemal assembly factor 11", "gene_name": "Dnaaf11", "organism": "Mouse", "refseq_name": "dynein axonemal assembly factor 11", "refseq_ac": [ { "id": "NP_062330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062330", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf11; Lrrc6; Lrtp; Mc2", "gene_names_refseq": "Dnaaf11; LRTP; Lrrc6", "protein_names_uniprotkb": "Dynein axonemal assembly factor 11; DNAAF11; Leucine-rich repeat-containing protein 6; Leucine-rich testis-specific protein; Protein tilB homolog; Testis-specific leucine-rich repeat protein", "protein_names_refseq": "dynein axonemal assembly factor 11; leucine rich repeat containing 6 (testis); leucine-rich repeat-containing protein 6; leucine-rich testis-specific protein; protein TILB homolog; testis-specific leucine-rich repeat protein", "tax_id": 10090, "disease": "primary ciliary dyskinesia 19 (Disease Ontology:DOID:0110608)", "pathway": " (mmu:54562)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10775177;17971504;27353389;37328841", "class_list": "", "function": "Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia (PubMed:27353389). Acts as a crucial component in the formation and motility of spermatozoal flagella (By similarity)., [UniProtKB, PubMed, UniProtKB]; LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus. Publication Status: Online-Only, [RefSeq, PubMed]; Lrrc6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia., [RefSeq, PubMed]; Our results suggest that outer dynein arms proteins may be transported from the cytoplasm to the cilia by an Lrrc6-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUG2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0008584 male gonad development;GO:0044458 motile cilium assembly;GO:0061512 protein localization to cilium;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88978-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12032-1", "uniprot_id": [ { "id": "TIMP1_MOUSE", "url": "https://www.uniprot.org/uniprot/P12032", "type": "external" } ], "mass": 22628.0, "length": 205, "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "Timp1", "organism": "Mouse", "refseq_name": "metalloproteinase inhibitor 1 isoform a precursor", "refseq_ac": [ { "id": "NP_001037849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037849", "type": "external" } ], "gene_names_uniprotkb": "Timp1; Timp-1; Timp", "gene_names_refseq": "Clgi; EPA; TIMP-1; TPA-S1; Timp1; Timp", "protein_names_uniprotkb": "Metalloproteinase inhibitor 1; Collagenase inhibitor 16C8 fibroblast; EPA; Erythroid-potentiating activity; TIMP-1; TPA-S1; TPA-induced protein; Tissue inhibitor of metalloproteinases 1", "protein_names_refseq": "TPA-induced protein; collagenase inhibitor 16C8 fibroblast; erythroid-potentiating activity; metalloproteinase inhibitor 1 isoform a precursor; metalloproteinase inhibitor 1; tissue inhibitor of metalloproteinases 1", "tax_id": 10090, "disease": "stroke (Disease Ontology:DOID:0051061); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); heart disease (Disease Ontology:DOID:114); Kawasaki disease (Disease Ontology:DOID:13378); cholestasis (Disease Ontology:DOID:13580); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); vascular disease (Disease Ontology:DOID:178); preretinal fibrosis (Disease Ontology:DOID:2006); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); degenerative disc disease (Disease Ontology:DOID:90); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (mmu:21857); (R-MMU-114608); (R-MMU-1592389); (R-MMU-381426); (R-MMU-8957275); (R-MMU-9839383)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;23522389;2744464;3024122;3034603;34428180;3670294;6179042", "class_list": "", "function": "Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P20064;Q61720", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0030414 peptidase inhibitor activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1905049 negative regulation of metallopeptidase activity;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0043086 negative regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P12032-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19473-1", "uniprot_id": [ { "id": "TUR8_MOUSE", "url": "https://www.uniprot.org/uniprot/P19473", "type": "external" } ], "mass": 25758.0, "length": 224, "protein_name": "Tumor rejection antigen P815A", "gene_name": "Trap1a", "organism": "Mouse", "refseq_name": "tumor rejection antigen P815A", "refseq_ac": [ { "id": "NP_035765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035765", "type": "external" } ], "gene_names_uniprotkb": "Trap1a; P1a", "gene_names_refseq": "Tra-P1A; Trap1a", "protein_names_uniprotkb": "Tumor rejection antigen P815A", "protein_names_refseq": "tumor rejection antigen P815A", "tax_id": 10090, "disease": "", "pathway": " (mmu:22037)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16912204;1903428;27063468;39384196", "class_list": "", "function": "Since multiple lineages of tumor cells share the tumor antigen P1A, we adoptively transferred transgenic T cells specific for P1A into mice with established P1A-expressing tumors., [RefSeq, PubMed]; These data reveal that Trap1a is an X-linked regulator that affects the differentiation potential of progenitor cells into T cells through a Notch-independent mechanism and identify an important function for the Trap1a gene, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19473-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62996-1", "uniprot_id": [ { "id": "TRA2B_MOUSE", "url": "https://www.uniprot.org/uniprot/P62996", "type": "external" } ], "mass": 33666.0, "length": 288, "protein_name": "Transformer-2 protein homolog beta", "gene_name": "Tra2b", "organism": "Mouse", "refseq_name": "transformer-2 protein homolog beta isoform 2", "refseq_ac": [ { "id": "NP_001317483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317483", "type": "external" } ], "gene_names_uniprotkb": "Tra2b; Sfrs10; Silg41", "gene_names_refseq": "5730405G21Rik; D16Ertd266e; SIG-41; Sfrs10; Silg41; TRA2beta; Tra2b", "protein_names_uniprotkb": "Transformer-2 protein homolog beta; SIG-41; Silica-induced gene 41 protein; Splicing factor, arginine/serine-rich 10; TRA-2 beta; TRA2-beta; Transformer-2 protein homolog B", "protein_names_refseq": "silica-induced gene 41 protein; splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila); transformer 2 beta homolog; transformer-2 protein homolog B; transformer-2 protein homolog beta isoform 2; transformer-2 protein homolog beta", "tax_id": 10090, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (mmu:20462); (R-MMU-72163); (R-MMU-72203); (R-MMU-9013418); (R-MMU-9013422); (R-MMU-9770562)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "21750661;24129315;28785060;31219806;36861193;39265028;7868905;8674539", "class_list": "", "function": "Autoregulated splicing of TRA2beta programs T cell fate in response to antigen-receptor stimulation., [RefSeq, PubMed]; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing (PubMed:28785060). Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity)., [UniProtKB, UniProtKB, PubMed]; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing., [UniProtKB, UniProtKB]; Tra2beta Enhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O15449;Q15815;Q64283", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005681 spliceosomal complex;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0071333 cellular response to glucose stimulus;GO:0021796 cerebral cortex regionalization;GO:0043484 regulation of RNA splicing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62996-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05BQ1-1", "uniprot_id": [ { "id": "TUTLA_MOUSE", "url": "https://www.uniprot.org/uniprot/Q05BQ1", "type": "external" } ], "mass": 127330.0, "length": 1179, "protein_name": "Protein turtle homolog A", "gene_name": "Igsf9", "organism": "Mouse", "refseq_name": "protein turtle homolog A precursor", "refseq_ac": [ { "id": "NP_001139272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139272", "type": "external" } ], "gene_names_uniprotkb": "Igsf9; Dasm1; Igsf9a; Nrt1", "gene_names_refseq": "644ETD8; Dasm1; Igsf9; Kiaa1355-hp; NRT1; Ncaml; igSF9A; mKIAA1355", "protein_names_uniprotkb": "Protein turtle homolog A; Dendrite arborization and synapse maturation protein 1; IgSF9A; Immunoglobulin superfamily member 9A", "protein_names_refseq": "NCAM-like protein NRT1; dendrite arborization and synapse maturation protein 1; immunoglobulin superfamily member 9A; protein turtle homolog A precursor; protein turtle homolog A", "tax_id": 10090, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (mmu:93842)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11401431;11991715;15340156;15340157;21750661;26495903;33933448;34428180", "class_list": "", "function": "Functions in dendrite outgrowth and synapse maturation., [UniProtKB, PubMed, PubMed]; MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8R1J8;Q925P4", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030424 axon;GO:0030425 dendrite;GO:0060077 inhibitory synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0090128 regulation of synapse maturation;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05BQ1-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000100000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q38HM4-1", "uniprot_id": [ { "id": "TRI63_MOUSE", "url": "https://www.uniprot.org/uniprot/Q38HM4", "type": "external" } ], "mass": 39491.0, "length": 350, "protein_name": "E3 ubiquitin-protein ligase TRIM63", "gene_name": "Trim63", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trim63; Murf1; Rf1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM63; 2.3.2.27; MuRF-1; MuRF1; Muscle RING finger protein 1; Muscle-specific RING finger protein 1; RING-type E3 ubiquitin transferase TRIM63; Tripartite motif-containing protein 63", "protein_names_refseq": "", "tax_id": 10090, "disease": "primary pulmonary hypertension (Disease Ontology:DOID:14557); muscular atrophy (Disease Ontology:DOID:767); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (mmu:433766); (R-MMU-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12773310;15596539;15601779;18222470;21750661", "class_list": "", "function": "E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWC4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031432 titin binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030018 Z disc;GO:0031430 M band", "go_biological_process": "GO:0014904 myotube cell development;GO:0006936 muscle contraction;GO:0045087 innate immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0071549 cellular response to dexamethasone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q38HM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NCC9-1", "uniprot_id": [ { "id": "TRI58_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5NCC9", "type": "external" } ], "mass": 55371.0, "length": 485, "protein_name": "E3 ubiquitin-protein ligase TRIM58", "gene_name": "Trim58", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM58", "refseq_ac": [ { "id": "NP_001034136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034136", "type": "external" } ], "gene_names_uniprotkb": "Trim58; Gm16", "gene_names_refseq": "Gm16; Gm1783; Trim58", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM58; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM58; Tripartite motif-containing protein 58", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM58; RING-type E3 ubiquitin transferase TRIM58; tripartite motif-containing protein 58", "tax_id": 10090, "disease": "", "pathway": " (mmu:216781)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25241935;34428180", "class_list": "", "function": "E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization., [UniProtKB, UniProtKB]; Trim58 binds dynein, promotes its proteasomal degradation and regulates terminal erythropoiesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0045504 dynein heavy chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0061931 positive regulation of erythrocyte enucleation;GO:1902838 regulation of nuclear migration along microtubule;GO:0045087 innate immune response;GO:0000209 protein polyubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5NCC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1V4-1", "uniprot_id": [ { "id": "TMED4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R1V4", "type": "external" } ], "mass": 26022.0, "length": 227, "protein_name": "Transmembrane emp24 domain-containing protein 4", "gene_name": "Tmed4", "organism": "Mouse", "refseq_name": "transmembrane emp24 domain-containing protein 4 precursor", "refseq_ac": [ { "id": "NP_598781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598781", "type": "external" } ], "gene_names_uniprotkb": "Tmed4; Ers25", "gene_names_refseq": "1110014L17Rik; Tmed4", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 4; ERS25; Endoplasmic reticulum stress-response protein 25; p24 family protein alpha-3; p24alpha3; p26", "protein_names_refseq": "ERS25; endoplasmic reticulum stress-response protein 25; p24 family protein alpha-3; p24alpha3; p26; transmembrane emp24 domain-containing protein 4 precursor; transmembrane emp24 domain-containing protein 4; transmembrane emp24 protein transport domain containing 4", "tax_id": 10090, "disease": "", "pathway": " (mmu:103694)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18326488;21750661;30899004;31219806;34428180;40997131", "class_list": "", "function": "ERS25 may play a critical role in regulation of heat-shock response and apoptosis, [RefSeq, PubMed]; Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TY55", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q8R1V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62361-1", "uniprot_id": [ { "id": "TRH_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62361", "type": "external" } ], "mass": 29195.0, "length": 256, "protein_name": "Pro-thyrotropin-releasing hormone", "gene_name": "Trh", "organism": "Mouse", "refseq_name": "thyrotropin releasing hormone preproprotein", "refseq_ac": [ { "id": "NP_033452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033452", "type": "external" } ], "gene_names_uniprotkb": "Trh", "gene_names_refseq": "Pro-TRH; Trf; Trh", "protein_names_uniprotkb": "Pro-thyrotropin-releasing hormone; Pro-TRH; Prothyroliberin; Protirelin; TRF; TSH-releasing factor; Thyroliberin; Thyrotropin-releasing factor", "protein_names_refseq": "TSH-releasing factor; pro-thyrotropin-releasing hormone; prothyroliberin; protirelin; thyrotropin releasing hormone preproprotein; thyrotropin-releasing factor", "tax_id": 10090, "disease": "hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (mmu:22044); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1323011;6432893", "class_list": "", "function": "Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems., [UniProtKB]; Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone., [RefSeq, PubMed]; This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMT4", "ec_number_list": [], "go_molecular_function": "GO:0008437 thyrotropin-releasing hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032024 positive regulation of insulin secretion;GO:0045471 response to ethanol;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62361-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NXM3-1", "uniprot_id": [ { "id": "TM130_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6NXM3", "type": "external" } ], "mass": 46628.0, "length": 419, "protein_name": "Transmembrane protein 130", "gene_name": "Tmem130", "organism": "Mouse", "refseq_name": "transmembrane protein 130 precursor", "refseq_ac": [ { "id": "NP_808403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808403", "type": "external" } ], "gene_names_uniprotkb": "Tmem130", "gene_names_refseq": "C130036G08; Tmem130", "protein_names_uniprotkb": "Transmembrane protein 130", "protein_names_refseq": "transmembrane protein 130 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:243339)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10.1101/2023.09.13.557529", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8C4P6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6NXM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ZWY6-1", "uniprot_id": [ { "id": "U2D2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6ZWY6", "type": "external" } ], "mass": 16659.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D2B", "gene_name": "Ube2d2b", "organism": "Mouse", "refseq_name": "ubiquitin-conjugating enzyme E2 D2B", "refseq_ac": [ { "id": "NP_001263326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263326", "type": "external" } ], "gene_names_uniprotkb": "Ube2d2b", "gene_names_refseq": "1700013N18Rik; Ube2d2b", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2B; 2.3.2.23; E2 ubiquitin-conjugating enzyme D2B; Ubiquitin carrier protein D2B; Ubiquitin-protein ligase D2B", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme D2B; ubiquitin carrier protein D2B; ubiquitin-conjugating enzyme E2 D2B; ubiquitin-protein ligase D2B", "tax_id": 10090, "disease": "", "pathway": " (mmu:73318)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16024774", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIG-I in response to viral infection (By similarity). Plays a role in early maturation of the testis., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070979 protein K11-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0071276 cellular response to cadmium ion;GO:1903841 cellular response to arsenite(3-)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6ZWY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M710-1", "uniprot_id": [ { "id": "TR125_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M710", "type": "external" } ], "mass": 36072.0, "length": 311, "protein_name": "Taste receptor type 2 member 125", "gene_name": "Tas2r125", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 125", "refseq_ac": [ { "id": "NP_996910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996910", "type": "external" } ], "gene_names_uniprotkb": "Tas2r125; T2r59", "gene_names_refseq": "T2R26; Tas2r125; Tas2r25; mGR25; mt2r59", "protein_names_uniprotkb": "Taste receptor type 2 member 125; T2R125; mT2R59", "protein_names_refseq": "T2R125; taste receptor type 2 member 125", "tax_id": 10090, "disease": "", "pathway": " (mmu:387352)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12679530", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7M710-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M713-1", "uniprot_id": [ { "id": "TR116_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7M713", "type": "external" } ], "mass": 35095.0, "length": 305, "protein_name": "Taste receptor type 2 member 116", "gene_name": "Tas2r116", "organism": "Mouse", "refseq_name": "taste receptor type 2 member 116", "refseq_ac": [ { "id": "NP_444442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444442", "type": "external" } ], "gene_names_uniprotkb": "Tas2r116; T2r56", "gene_names_refseq": "T2R16; TRB1; TRB4; Tas2r116; Tas2r14; Tas2r16; Tas2r7; mGR16; mt2r56", "protein_names_uniprotkb": "Taste receptor type 2 member 116; T2R116; TRB1; TRB4; mT2R56", "protein_names_refseq": "T2R116; candidate taste receptor mt2r56; taste receptor type 2 member 116; taste receptor, type 2, member 14; taste receptor, type 2, member 7", "tax_id": 10090, "disease": "", "pathway": " (mmu:112408)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10766242;12679530;27342779", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]; Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKA1;Q9JKA4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7M713-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BG71-1", "uniprot_id": [ { "id": "TYW2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BG71", "type": "external" } ], "mass": 50299.0, "length": 446, "protein_name": "tRNA wybutosine-synthesizing protein 2 homolog", "gene_name": "Tyw2", "organism": "Mouse", "refseq_name": "tRNA wybutosine-synthesizing protein 2 homolog", "refseq_ac": [ { "id": "NP_080918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080918", "type": "external" } ], "gene_names_uniprotkb": "Tyw2; Trmt12", "gene_names_refseq": "4632406N01Rik; Trmt12; Tyw2", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 2 homolog; 2.5.1.114; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2", "protein_names_refseq": "alpha-amino-alpha-carboxypropyl transferase TYW2; tRNA methyltranferase 12 homolog; tRNA methyltransferase 12; tRNA wybutosine-synthesizing protein 2 homolog; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; tRNA-yW-synthesizing protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:68260)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36583994", "class_list": "", "function": "S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5W5;Q7TNQ8;Q9D2N1", "ec_number_list": [ { "id": "2.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.114", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0102522 tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8BG71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BHM9-1", "uniprot_id": [ { "id": "TM11F_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BHM9", "type": "external" } ], "mass": 49776.0, "length": 439, "protein_name": "Transmembrane protease serine 11F", "gene_name": "Tmprss11f", "organism": "Mouse", "refseq_name": "transmembrane protease serine 11F", "refseq_ac": [ { "id": "NP_848845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848845", "type": "external" } ], "gene_names_uniprotkb": "Tmprss11f; Hatl4", "gene_names_refseq": "4631408C20; 4732406D01Rik; Tmprss11f", "protein_names_uniprotkb": "Transmembrane protease serine 11F; 3.4.21.-; Airway trypsin-like protease 4", "protein_names_refseq": "airway trypsin-like protease 4; transmembrane protease serine 11F", "tax_id": 10090, "disease": "", "pathway": " (mmu:243083)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15328353;28338078", "class_list": "", "function": "Probable serine protease., [UniProtKB]; Study reveals a role of HAT-L4 in the epidermal barrier function to prevent body fluid loss, providing another example of cell membrane-bound serine proteases in epidermal development and function. Erratum:[Sci Rep. 2020 Apr 10;10(1):6467. doi: 10.1038/s41598-020-62767-5. PMID: 32277073] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0016485 protein processing;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8BHM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BNV1-1", "uniprot_id": [ { "id": "TRM2A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BNV1", "type": "external" } ], "mass": 67488.0, "length": 613, "protein_name": "tRNA (uracil-5-)-methyltransferase homolog A", "gene_name": "Trmt2a", "organism": "Mouse", "refseq_name": "tRNA (uracil-5-)-methyltransferase homolog A isoform 2", "refseq_ac": [ { "id": "NP_001074468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074468", "type": "external" } ], "gene_names_uniprotkb": "Trmt2a; Htf9-c; Htf9c", "gene_names_refseq": "Htf9c; Trmt2a", "protein_names_uniprotkb": "tRNA (uracil-5-)-methyltransferase homolog A; 2.1.1.-; 2.1.1.35; HpaII tiny fragments locus 9c protein; mRNA (uracil-5-)-methyltransferase TRMT2A", "protein_names_refseq": "TRM2 tRNA methyltransferase 2 homolog A; hpaII tiny fragments locus 9c protein; mRNA (uracil-5-)-methyltransferase TRMT2A; tRNA (uracil-5-)-methyltransferase homolog A isoform 2; tRNA (uracil-5-)-methyltransferase homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:15547)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1889746;21750661;25428506;30084848;30779550;9224656;9417108", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs. Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs. Also able to mediate the formation of 5-methyl-uridine in some mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70221;P70222;Q3UYU2;Q78E15;Q80VN8", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent;GO:0008169 C-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006397 mRNA processing;GO:0008033 tRNA processing;GO:0032259 methylation;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8BNV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BQJ6-1", "uniprot_id": [ { "id": "TRM2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BQJ6", "type": "external" } ], "mass": 55476.0, "length": 493, "protein_name": "tRNA (uracil-5-)-methyltransferase homolog B", "gene_name": "Trmt2b", "organism": "Mouse", "refseq_name": "tRNA (uracil-5-)-methyltransferase homolog B isoform a", "refseq_ac": [ { "id": "NP_001161466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161466", "type": "external" } ], "gene_names_uniprotkb": "Trmt2b", "gene_names_refseq": "4732479N06Rik; Trmt2b", "protein_names_uniprotkb": "tRNA (uracil-5-)-methyltransferase homolog B; 2.1.1.-; 2.1.1.35; TRM2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B", "protein_names_refseq": "TRM2 homolog B; TRM2 homolog; TRM2 tRNA methyltransferase 2 homolog B; rRNA (uracil-5-)-methyltransferase TRMT2B; tRNA (uracil(54)-C(5))-methyltransferase homolog; tRNA (uracil-5-)-methyltransferase homolog B isoform a; tRNA (uracil-5-)-methyltransferase homolog B; tRNA (uracil-5-)-methyltransferase homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:215201)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31736397;35820727", "class_list": "", "function": "Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31736397). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs (PubMed:31736397). Specifically methylates the uridine in position 425 of 12S rRNA (m5U425) (PubMed:31736397). Does not affect RNA stability or mitochondrial translation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m(5)U formation in both tRNA and rRNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CE55", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent;GO:0070041 rRNA (uridine-C5-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008033 tRNA processing;GO:0006396 RNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BQJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BVW3-1", "uniprot_id": [ { "id": "TRI14_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BVW3", "type": "external" } ], "mass": 49641.0, "length": 440, "protein_name": "Tripartite motif-containing protein 14", "gene_name": "Trim14", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 14", "refseq_ac": [ { "id": "NP_083353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083353", "type": "external" } ], "gene_names_uniprotkb": "Trim14; Kiaa0129; Pub", "gene_names_refseq": "5830400N10Rik; Trim14; pub", "protein_names_uniprotkb": "Tripartite motif-containing protein 14; PU.1-binding protein", "protein_names_refseq": "PU.1 binding protein Pub; tripartite motif-containing protein 14", "tax_id": 10090, "disease": "", "pathway": " (mmu:74735)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14592421;16254642;24092016;26740625;27666593;31219806;34428180;35145029;37503784;37562033", "class_list": "", "function": "An Antiviral Role for TRIM14 in Ebola Virus Infection., [RefSeq, PubMed]; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421). Also inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation (PubMed:35145029)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (PubMed:14592421)., [UniProtKB, PubMed, UniProtKB, PubMed]; Pub gene participates in early stages of differentiation of embryonic stem cells leading to the formation of embryoid bodies., [RefSeq, PubMed]; These results demonstrate the presence of the similar mechanism of trim14 gene action in different types of mammalian cells., [RefSeq, PubMed]; Tripartite motif-containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1AVH3;Q6A0C3;Q762I6;Q9D3G8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0045335 phagocytic vesicle", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BVW3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BW70-1", "uniprot_id": [ { "id": "UBP38_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BW70", "type": "external" } ], "mass": 116102.0, "length": 1042, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 38", "gene_name": "Usp38", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 38", "refseq_ac": [ { "id": "NP_081830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081830", "type": "external" } ], "gene_names_uniprotkb": "Usp38", "gene_names_refseq": "4631402N15Rik; 4833420O05Rik; Usp38; mKIAA1891", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 38; 3.4.19.12; Deubiquitinating enzyme 38; Ubiquitin thioesterase 38; Ubiquitin-specific-processing protease 38", "protein_names_refseq": "deubiquitinating enzyme 38; ubiquitin carboxyl-terminal hydrolase 38; ubiquitin specific protease 38; ubiquitin thioesterase 38; ubiquitin thiolesterase 38; ubiquitin-specific-processing protease 38", "tax_id": 10090, "disease": "", "pathway": " (mmu:74841)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1101/2023.09.13.557529;25428507;27692986;34428180;35238669;38288617;38481817;38937697", "class_list": "", "function": "Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response (PubMed:27692986, PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation. Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells. Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1. Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage. Also acts as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'-linked ubiquitin chains to lower its histone deacetylase activity. Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation. Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E. Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation., [UniProtKB, UniProtKB, PubMed, PubMed]; USP38 exacerbates pressure overload-induced left ventricular electrical remodeling. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8BWL1;Q8BX03", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031647 regulation of protein stability;GO:0000082 G1/S transition of mitotic cell cycle;GO:0070936 protein K48-linked ubiquitination;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8BW70-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.1000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C2S0-1", "uniprot_id": [ { "id": "UBP44_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C2S0", "type": "external" } ], "mass": 80479.0, "length": 711, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 44", "gene_name": "Usp44", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 44", "refseq_ac": [ { "id": "NP_001193780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193780", "type": "external" } ], "gene_names_uniprotkb": "Usp44", "gene_names_refseq": "E430004F17Rik; Usp44", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 44; 3.4.19.12; Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44", "protein_names_refseq": "inactive deubiquitinating enzyme 44; inactive ubiquitin carboxyl-terminal hydrolase 44; inactive ubiquitin thioesterase 44; inactive ubiquitin-specific-processing protease 44; ubiquitin carboxyl-terminal hydrolase 44; ubiquitin specific peptidase 49 pseudogene", "tax_id": 10090, "disease": "", "pathway": " (mmu:327799); (R-MMU-5689880)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "20402667;21853124;23187126;30639577;33937266;34428180;40021952", "class_list": "", "function": "Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset (PubMed:23187126). Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Also promotes the deubiquitination of histone H2A and H2B. Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (By similarity). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (PubMed:23187126). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability. Also plays a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias., [RefSeq, PubMed]; USP44 inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry., [RefSeq, PubMed]; USP44 is dispensable for the normal physiology of hematopoietic and immune systems, and its functions in these systems are likely redundant with other USP family proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016579 protein deubiquitination;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8C2S0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8C353-1", "uniprot_id": [ { "id": "TM252_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8C353", "type": "external" } ], "mass": 20376.0, "length": 183, "protein_name": "Transmembrane protein 252", "gene_name": "Tmem252", "organism": "Mouse", "refseq_name": "transmembrane protein 252", "refseq_ac": [ { "id": "NP_898983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898983", "type": "external" } ], "gene_names_uniprotkb": "Tmem252", "gene_names_refseq": "E030010A14Rik; Tmem252", "protein_names_uniprotkb": "Transmembrane protein 252", "protein_names_refseq": "transmembrane protein 252; transmembrane protein C9orf71 homolog", "tax_id": 10090, "disease": "", "pathway": " (mmu:226040)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27802388;30084848;34428180", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP68", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8C353-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K093-1", "uniprot_id": [ { "id": "TRHDE_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8K093", "type": "external" } ], "mass": 122148.0, "length": 1066, "protein_name": "Thyrotropin-releasing hormone-degrading ectoenzyme", "gene_name": "Trhde", "organism": "Mouse", "refseq_name": "thyrotropin-releasing hormone-degrading ectoenzyme", "refseq_ac": [ { "id": "NP_666353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_666353", "type": "external" } ], "gene_names_uniprotkb": "Trhde", "gene_names_refseq": "9330155P21Rik; Trhde", "protein_names_uniprotkb": "Thyrotropin-releasing hormone-degrading ectoenzyme; 3.4.19.6; PAP-II; Pyroglutamyl-peptidase II; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase; Thyroliberinase", "protein_names_refseq": "PAP-II; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone-degrading ectoenzyme", "tax_id": 10090, "disease": "", "pathway": " (mmu:237553)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;21750661;33300544", "class_list": "", "function": "Specific inactivation of TRH after its release., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A0A6I8MX30", "ec_number_list": [], "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008237 metallopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8K093-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5K2-1", "uniprot_id": [ { "id": "UBP33_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R5K2", "type": "external" } ], "mass": 102728.0, "length": 909, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 33", "gene_name": "Usp33", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 33 isoform 3", "refseq_ac": [ { "id": "NP_001239415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239415", "type": "external" } ], "gene_names_uniprotkb": "Usp33; Vdu1", "gene_names_refseq": "9830169D19Rik; Usp33; Vdu1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 33; 3.4.19.12; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33; VHL-interacting deubiquitinating enzyme 1", "protein_names_refseq": "VHL-interacting deubiquitinating enzyme 1; Vhlh-interacting deubiquitinating enzyme 1; deubiquitinating enzyme 33; pVHL-interacting deubiquitinating enzyme 1; ubiquitin carboxyl-terminal hydrolase 33 isoform 3; ubiquitin carboxyl-terminal hydrolase 33; ubiquitin specific protease 33; ubiquitin thioesterase 33; ubiquitin thiolesterase 33; ubiquitin-specific-processing protease 33", "tax_id": 10090, "disease": "", "pathway": " (mmu:170822); (R-MMU-5689880); (R-MMU-9010553)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11739384;19684588;19706539;21750661;22872234;24855649;25428506;30084848;34203471;34428180;37256445", "class_list": "", "function": "Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G protein-coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains., [UniProtKB, PubMed, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation, [RefSeq, PubMed]; MiR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway. Erratum:[Mol Cell Biochem. 2024 Feb;479(2):445. doi: 10.1007/s11010-023-04803-2. PMID: 37432634], [RefSeq, PubMed]; Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UP32;Q5FWK0;Q8K0I3;Q99K22", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031267 small GTPase binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R5K2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD31-1", "uniprot_id": [ { "id": "TPSNR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VD31", "type": "external" } ], "mass": 48733.0, "length": 451, "protein_name": "Tapasin-related protein", "gene_name": "Tapbpl", "organism": "Mouse", "refseq_name": "tapasin-related protein precursor", "refseq_ac": [ { "id": "NP_663366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663366", "type": "external" } ], "gene_names_uniprotkb": "Tapbpl", "gene_names_refseq": "TAPBPL-R; Tapbplr; Tapbpl", "protein_names_uniprotkb": "Tapasin-related protein; TAP-binding protein-like; TAP-binding protein-related protein; TAPASIN-R; TAPBP-R; Tapasin-like", "protein_names_refseq": "TAP-binding protein-related protein; TAPASIN-R; TAPBP-R; tapasin-like; tapasin-related protein precursor; tapasin-related protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:213233)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10.1101/2023.09.13.557529;11920573;34428180", "class_list": "", "function": "Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression., [UniProtKB, UniProtKB]; Focuses on cloning and characterization of human TAPBP-R but also identifies the mouse ortholog Tapbpl., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "E9QN33", "ec_number_list": [], "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0062061 TAP complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0042824 MHC class I peptide loading complex", "go_biological_process": "GO:0002502 peptide antigen assembly with MHC class I protein complex;GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VD31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925D8-1", "uniprot_id": [ { "id": "TS1R3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q925D8", "type": "external" } ], "mass": 94561.0, "length": 858, "protein_name": "Taste receptor type 1 member 3", "gene_name": "Tas1r3", "organism": "Mouse", "refseq_name": "taste receptor type 1 member 3 precursor", "refseq_ac": [ { "id": "NP_114078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114078", "type": "external" } ], "gene_names_uniprotkb": "Tas1r3; Sac; T1r3; Tr3", "gene_names_refseq": "Sac; T1r3; Tas1r3", "protein_names_uniprotkb": "Taste receptor type 1 member 3; Saccharin preference protein; Sweet taste receptor T1R3", "protein_names_refseq": "saccharin preference protein; sweet taste receptor T1R3; taste receptor type 1 member 3 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:83771); (R-MMU-418594); (R-MMU-420499); (R-MMU-9717207)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "11319557;11322794;11326277;11331418;11509186;11555487;11773963;11894099;12869700;12892531;14636554;14749438;14999080;37938171", "class_list": "", "function": "Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses., [UniProtKB, PubMed, PubMed]; Sucralose regulates postprandial blood glucose in mice through intestinal sweet taste receptors Tas1r2/Tas1r3., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A2ADA0;Q91VA4;Q923K0;Q925A4;Q925D9", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:1903767 sweet taste receptor complex;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0038037 G protein-coupled receptor dimeric complex", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0007186 G protein-coupled receptor signaling pathway;GO:0050916 sensory perception of sweet taste;GO:0050917 sensory perception of umami taste", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q925D8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQ88-1", "uniprot_id": [ { "id": "TSN31_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQ88", "type": "external" } ], "mass": 22694.0, "length": 210, "protein_name": "Tetraspanin-31", "gene_name": "Tspan31", "organism": "Mouse", "refseq_name": "tetraspanin-31 isoform a", "refseq_ac": [ { "id": "NP_080258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080258", "type": "external" } ], "gene_names_uniprotkb": "Tspan31; Sas", "gene_names_refseq": "2700085A14Rik; Sas; Tspan31", "protein_names_uniprotkb": "Tetraspanin-31; Sarcoma-amplified sequence homolog; Tspan-31", "protein_names_refseq": "sarcoma amplified sequence; sarcoma-amplified sequence homolog; tetraspanin-31 isoform a; tspan-31", "tax_id": 10090, "disease": "", "pathway": " (mmu:67125)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19349973;26495903;26740625;29187734;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9CUY7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9CQ88-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQC4-1", "uniprot_id": [ { "id": "TM216_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQC4", "type": "external" } ], "mass": 16160.0, "length": 141, "protein_name": "Transmembrane protein 216", "gene_name": "Tmem216", "organism": "Mouse", "refseq_name": "transmembrane protein 216 isoform 1", "refseq_ac": [ { "id": "NP_001264789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264789", "type": "external" } ], "gene_names_uniprotkb": "Tmem216", "gene_names_refseq": "1110017C22Rik; 2810441K11Rik; 4921533J23Rik; A930021F15Rik; Tmem216", "protein_names_uniprotkb": "Transmembrane protein 216; Thymus atrophy-related protein", "protein_names_refseq": "thymus atrophy-related protein; transmembrane protein 216 isoform 1", "tax_id": 10090, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 98 (Disease Ontology:DOID:0061109); Meckel syndrome 2 (Disease Ontology:DOID:0070116); Joubert syndrome 2 (Disease Ontology:DOID:0110988)", "pathway": " (mmu:68642); (R-MMU-5620912)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21725307;38261656", "class_list": "", "function": "Essential for primary ciliogenesis and embryonic development, facilitating the activation of Hedgehog (Hh) signaling pathway. Disrupts the interaction of GLI2 and GLI3 with the negative regulator SUFU. Inhibiting SUFU's interaction with GLI2 promotes the entry of GLI2 into the nucleus, allowing it to activate Hh target gene expression. Disrupting SUFU's interaction with GLI3 prevents its conversion into the repressor form, leading to increased nuclear GLI3 and enhanced Hh signaling (PubMed:38261656). Required for the proper development and structural integrity of photoreceptor outer segment disks, ensuring normal outer segment morphogenesis and survival of photoreceptors (By similarity)., [UniProtKB, UniProtKB, PubMed]; TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis., [RefSeq, PubMed]; This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3YUA1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9CQC4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9CQE2-1", "uniprot_id": [ { "id": "TM223_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9CQE2", "type": "external" } ], "mass": 21857.0, "length": 199, "protein_name": "Transmembrane protein 223", "gene_name": "Tmem223", "organism": "Mouse", "refseq_name": "transmembrane protein 223", "refseq_ac": [ { "id": "NP_080067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080067", "type": "external" } ], "gene_names_uniprotkb": "Tmem223", "gene_names_refseq": "0610006I08Rik; Tmem223", "protein_names_uniprotkb": "Transmembrane protein 223", "protein_names_refseq": "transmembrane protein 223", "tax_id": 10090, "disease": "", "pathway": " (mmu:66836)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;31219806;34428180;36210013;37507081", "class_list": "", "function": "Mitochondrial ribosome-associated protein involved in the first steps of cytochrome c oxidase complex (complex IV) biogenesis. Stimulates the translation of MT-CO1 mRNA and is a constituent of early MT-CO1 assembly intermediates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9CQE2-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.1100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2E9-1", "uniprot_id": [ { "id": "TM190_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2E9", "type": "external" } ], "mass": 18491.0, "length": 166, "protein_name": "Transmembrane protein 190", "gene_name": "Tmem190", "organism": "Mouse", "refseq_name": "transmembrane protein 190 precursor", "refseq_ac": [ { "id": "NP_084304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084304", "type": "external" } ], "gene_names_uniprotkb": "Tmem190", "gene_names_refseq": "4930572D21Rik; Tmem190", "protein_names_uniprotkb": "Transmembrane protein 190", "protein_names_refseq": "transmembrane protein 190 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:78052)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21273369", "class_list": "", "function": "A mouse sperm protein complex(es) including TMEM190 plays an indirect role(s) in sperm-oocyte fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0002079 inner acrosomal membrane", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9D2E9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2F0-1", "uniprot_id": [ { "id": "TM210_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2F0", "type": "external" } ], "mass": 15214.0, "length": 147, "protein_name": "Transmembrane protein 210", "gene_name": "Tmem210", "organism": "Mouse", "refseq_name": "transmembrane protein 210 precursor", "refseq_ac": [ { "id": "NP_084331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084331", "type": "external" } ], "gene_names_uniprotkb": "Tmem210", "gene_names_refseq": "4930571C24Rik; Tmem210", "protein_names_uniprotkb": "Transmembrane protein 210", "protein_names_refseq": "transmembrane protein 210 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:78217)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D2F0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D2H5-1", "uniprot_id": [ { "id": "TRI42_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D2H5", "type": "external" } ], "mass": 82953.0, "length": 723, "protein_name": "Tripartite motif-containing protein 42", "gene_name": "Trim42", "organism": "Mouse", "refseq_name": "tripartite motif-containing protein 42", "refseq_ac": [ { "id": "NP_084495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084495", "type": "external" } ], "gene_names_uniprotkb": "Trim42", "gene_names_refseq": "4930486B16Rik; Trim42", "protein_names_uniprotkb": "Tripartite motif-containing protein 42", "protein_names_refseq": "tripartite motif-containing protein 42", "tax_id": 10090, "disease": "", "pathway": " (mmu:78911)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QN55", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9D2H5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D3D0-1", "uniprot_id": [ { "id": "TTPAL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D3D0", "type": "external" } ], "mass": 38836.0, "length": 343, "protein_name": "Alpha-tocopherol transfer protein-like", "gene_name": "Ttpal", "organism": "Mouse", "refseq_name": "alpha-tocopherol transfer protein-like isoform 2", "refseq_ac": [ { "id": "NP_001292732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292732", "type": "external" } ], "gene_names_uniprotkb": "Ttpal", "gene_names_refseq": "3110080A02Rik; 5830472M02Rik; Ttpal", "protein_names_uniprotkb": "Alpha-tocopherol transfer protein-like", "protein_names_refseq": "alpha-tocopherol transfer protein-like isoform 2; alpha-tocopherol transfer protein-like", "tax_id": 10090, "disease": "", "pathway": " (mmu:76080)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;25428506", "class_list": "", "function": "May act as a protein that binds a hydrophobic ligand., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6PW51;Q3U0R3;Q7TS94", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9D3D0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9D563-1", "uniprot_id": [ { "id": "TM114_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9D563", "type": "external" } ], "mass": 24388.0, "length": 222, "protein_name": "Transmembrane protein 114", "gene_name": "Tmem114", "organism": "Mouse", "refseq_name": "transmembrane protein 114", "refseq_ac": [ { "id": "NP_083346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083346", "type": "external" } ], "gene_names_uniprotkb": "Tmem114; Cldn26", "gene_names_refseq": "4930511J11Rik; Cldn26; Tmem114", "protein_names_uniprotkb": "Transmembrane protein 114; Claudin-26", "protein_names_refseq": "claudin-26; transmembrane protein 114", "tax_id": 10090, "disease": "", "pathway": " (mmu:74720)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17492639;21276448;21689651", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9D563-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DAM7-1", "uniprot_id": [ { "id": "TM263_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9DAM7", "type": "external" } ], "mass": 11549.0, "length": 115, "protein_name": "Transmembrane protein 263", "gene_name": "Tmem263", "organism": "Mouse", "refseq_name": "transmembrane protein 263", "refseq_ac": [ { "id": "NP_001013046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013046", "type": "external" } ], "gene_names_uniprotkb": "Tmem263", "gene_names_refseq": "Tmem263", "protein_names_uniprotkb": "Transmembrane protein 263", "protein_names_refseq": "UPF0444 transmembrane protein C12orf23 homolog; transmembrane protein 263", "tax_id": 10090, "disease": "", "pathway": " (mmu:103266)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "22517741;22645316;25428506;26192747;30084848;30779550;32782141;32848054;34428180;34678516;35820727;35822049;38241182;40021952;40885482", "class_list": "", "function": "May play a role in bone development., [UniProtKB, UniProtKB]; Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9DAM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP52-1", "uniprot_id": [ { "id": "TWSG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EP52", "type": "external" } ], "mass": 24801.0, "length": 222, "protein_name": "Twisted gastrulation protein homolog 1", "gene_name": "Twsg1", "organism": "Mouse", "refseq_name": "twisted gastrulation protein homolog 1 precursor", "refseq_ac": [ { "id": "NP_075540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075540", "type": "external" } ], "gene_names_uniprotkb": "Twsg1; Tsg", "gene_names_refseq": "1810013J15Rik; 9030422N06Rik; D17Ertd403e; Tsg; Twg; Twsg1", "protein_names_uniprotkb": "Twisted gastrulation protein homolog 1", "protein_names_refseq": "twisted gastrulation homolog 1; twisted gastrulation protein homolog 1 precursor; twisted gastrulation protein homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:65960)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10.1101/2023.09.13.557529;11260715;11420619;12119341;12665593;15843411;16905550;21750661;25468951;25808976;31219806;34203471;34428180;36210013", "class_list": "", "function": "Acts as both a BMP-4 agonist in skeletogenesis and a BMP-4 antagonist in T-cell development, [RefSeq, PubMed]; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Our results show that BMP binding is required for TWSG1-mediated inhibition of osteoclast formation and function, and validate the critical functional regions within the TWSG1 protein for these interactions, [RefSeq, PubMed]; The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development., [RefSeq, PubMed]; The goal of this study was to examine whether mice carrying a mutation in a gene encoding Twsg1, which is associated with a low penetrance of holoprosencephaly, are sensitized to retinoic acid teratogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CCB1;Q8CEM6;Q99K77;Q9ERN7", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0030900 forebrain development;GO:0030509 BMP signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9EP52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESN2-1", "uniprot_id": [ { "id": "TRI39_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9ESN2", "type": "external" } ], "mass": 56369.0, "length": 488, "protein_name": "E3 ubiquitin-protein ligase TRIM39", "gene_name": "Trim39", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase TRIM39 isoform 1", "refseq_ac": [ { "id": "NP_077788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077788", "type": "external" } ], "gene_names_uniprotkb": "Trim39; Rnf23; Tfp", "gene_names_refseq": "1100001D15Rik; E130103K13Rik; RBCC-B30.2; Rnf23; Trim39; mKIAA4179; tfp", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM39; 2.3.2.27; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; Testis-abundant finger protein; Tripartite motif-containing protein 39", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM39 isoform 1; E3 ubiquitin-protein ligase TRIM39; RING-B box-coiled-coil-B30.2; RING-type E3 ubiquitin transferase TRIM39; ring finger protein 23; testis-abundant finger protein; tripartite motif-containing protein 39", "tax_id": 10090, "disease": "", "pathway": " (mmu:79263); (R-MMU-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11006080;21750661", "class_list": "", "function": "E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity)., [UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BPR5;Q8K0F7", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0050821 protein stabilization;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM4-1", "uniprot_id": [ { "id": "TR10B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9QZM4", "type": "external" } ], "mass": 42165.0, "length": 381, "protein_name": "Tumor necrosis factor receptor superfamily member 10B", "gene_name": "Tnfrsf10b", "organism": "Mouse", "refseq_name": "tumor necrosis factor receptor superfamily member 10B precursor", "refseq_ac": [ { "id": "NP_064671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064671", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf10b; Dr5; Killer", "gene_names_refseq": "DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB; Tnfrsf10b", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; MK", "protein_names_refseq": "KILLER/DR5 TRAIL death-inducing receptor; death receptor 5; tumor necrosis factor receptor superfamily member 10B precursor", "tax_id": 10090, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); urinary bladder cancer (Disease Ontology:DOID:11054); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); osteoarthritis (Disease Ontology:DOID:8398); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (mmu:21933); (R-MMU-202733); (R-MMU-3371378); (R-MMU-5218900); (R-MMU-69416); (R-MMU-75158)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10383128;14769851;16075062;18250455;25428506;26495903;30902834;37460623;38199990", "class_list": "", "function": "A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Antibody-based therapy targeting DR5 is an efficient strategy not only to eliminate TRAIL-sensitive tumor cells., [RefSeq, PubMed]; Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GSD9;Q9JJL5;Q9JJL6", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0045569 TRAIL binding;GO:0036463 TRAIL receptor activity;GO:0140319 receptor decoy activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034976 response to endoplasmic reticulum stress;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors;GO:0036462 TRAIL-activated apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R233-1", "uniprot_id": [ { "id": "TPSN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R233", "type": "external" } ], "mass": 49736.0, "length": 465, "protein_name": "Tapasin", "gene_name": "Tapbp", "organism": "Mouse", "refseq_name": "tapasin isoform 2 precursor", "refseq_ac": [ { "id": "NP_033344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033344", "type": "external" } ], "gene_names_uniprotkb": "Tapbp; Tapa", "gene_names_refseq": "D17Wsu91e; TPN; Tapbp", "protein_names_uniprotkb": "Tapasin; TAP-associated protein; TAP-binding protein; TPN; TPSN", "protein_names_refseq": "TAP-associated protein; TPSN; Tapasin; tapasin isoform 2 precursor", "tax_id": 10090, "disease": "severe combined immunodeficiency (Disease Ontology:DOID:627)", "pathway": " (mmu:21356); (R-MMU-983170)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10085102;12095710;21750661;22645316;23863903;28011936;28935714;29422902;30808808;31219806;33725478;34428180;37185848;37453647;9716645", "class_list": "", "function": "Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides., [RefSeq, PubMed]; Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication., [RefSeq, PubMed]; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)., [UniProtKB]; Qa-1b-restricted CD8+ T cells display characteristics of both conventional hypervariable T cells as well as invariant T cells and can be classified as semi-invariant T cells, with only conserved Valpha usage, positioned between these two known T cell subsets. Publication Status: Online-Only, [RefSeq, PubMed]; These results combined with mutation analyses allow us to propose a molecular model underlying MHC-I peptide selection by tapasin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70317;Q91YE0;Q91YE1;Q9QWT7;Q9Z1W3", "ec_number_list": [], "go_molecular_function": "GO:0046978 TAP1 binding;GO:0046979 TAP2 binding;GO:0023024 MHC class I protein complex binding;GO:0060090 molecular adaptor activity;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030670 phagocytic vesicle membrane;GO:0042824 MHC class I peptide loading complex", "go_biological_process": "GO:0050823 peptide antigen stabilization;GO:0006952 defense response;GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9R233-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2M6-1", "uniprot_id": [ { "id": "UBL3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9Z2M6", "type": "external" } ], "mass": 13180.0, "length": 117, "protein_name": "Ubiquitin-like protein 3", "gene_name": "Ubl3", "organism": "Mouse", "refseq_name": "ubiquitin-like protein 3 isoform a", "refseq_ac": [ { "id": "NP_036038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036038", "type": "external" } ], "gene_names_uniprotkb": "Ubl3", "gene_names_refseq": "HCG; MUB; Ubl3; mmMUB", "protein_names_uniprotkb": "Ubiquitin-like protein 3; MUB; Membrane-anchored ubiquitin-fold protein; MmMUB; Protein HCG-1", "protein_names_refseq": "membrane-anchored ubiquitin-fold protein; protein HCG-1; ubiquitin-like protein 3 isoform a; ubiquitin-like protein 3", "tax_id": 10090, "disease": "", "pathway": " (mmu:24109)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10375635;16831869;17322886;35411049", "class_list": "", "function": "Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FTW0;Q3UKM1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2M6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU02-1", "uniprot_id": [ { "id": "V1BR_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9WU02", "type": "external" } ], "mass": 46539.0, "length": 421, "protein_name": "Vasopressin V1b receptor", "gene_name": "Avpr1b", "organism": "Mouse", "refseq_name": "vasopressin V1b receptor", "refseq_ac": [ { "id": "NP_036054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036054", "type": "external" } ], "gene_names_uniprotkb": "Avpr1b; V1br", "gene_names_refseq": "AVPR V1b; AVPR V3; AVPR3; Avpr1b; V3/V1b; VIBR; VPR3", "protein_names_uniprotkb": "Vasopressin V1b receptor; AVPR V1b; AVPR V3; Antidiuretic hormone receptor 1b; V1bR; Vasopressin V3 receptor", "protein_names_refseq": "V3/V1b pituitary vasopressin receptor; antidiuretic hormone receptor 1b; arginine vasopressin type 1b receptor; vasopressin V1b receptor; vasopressin V3 receptor", "tax_id": 10090, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); bipolar disorder (Disease Ontology:DOID:3312); mood disorder (Disease Ontology:DOID:3324); pituitary adenoma (Disease Ontology:DOID:3829); ACTH-secreting pituitary adenoma (Disease Ontology:DOID:7004)", "pathway": " (mmu:26361); (R-MMU-388479); (R-MMU-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;10343284;10669045;12213135;12399951;21750661;38649033", "class_list": "", "function": "Computer vision analysis of mother-infant interaction identified efficient pup retrieval in V1b receptor knockout mice., [RefSeq, PubMed]; Mice without the V1bR exhibit markedly reduced aggression and modestly impaired social recognition., [RefSeq, PubMed]; Overexpression of the V3 vasopressin receptor in transgenic mice corticotropes leads to increased basal corticosterone., [RefSeq, PubMed]; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042127 regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WU02-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VCH8-1", "uniprot_id": [ { "id": "UBXN4_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8VCH8", "type": "external" } ], "mass": 56472.0, "length": 506, "protein_name": "UBX domain-containing protein 4", "gene_name": "Ubxn4", "organism": "Mouse", "refseq_name": "UBX domain-containing protein 4 isoform 1", "refseq_ac": [ { "id": "NP_080666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080666", "type": "external" } ], "gene_names_uniprotkb": "Ubxn4; Ubxd2; Ubxdc1", "gene_names_refseq": "1300013G12Rik; Ubxd2; Ubxn4; mKIAA0242", "protein_names_uniprotkb": "UBX domain-containing protein 4; Erasin; UBX domain-containing protein 2", "protein_names_refseq": "UBX domain containing 2; UBX domain-containing protein 2; UBX domain-containing protein 4 isoform 1; UBX domain-containing protein 4; erasin", "tax_id": 10090, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (mmu:67812)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16968747;17242355;21750661;25428506;28135057;28528544", "class_list": "", "function": "Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UGR4;Q8BW17", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8VCH8-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V83-1", "uniprot_id": [ { "id": "TTI1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V83", "type": "external" } ], "mass": 120814.0, "length": 1085, "protein_name": "TELO2-interacting protein 1 homolog", "gene_name": "Tti1", "organism": "Mouse", "refseq_name": "TELO2-interacting protein 1 homolog", "refseq_ac": [ { "id": "NP_083558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083558", "type": "external" } ], "gene_names_uniprotkb": "Tti1", "gene_names_refseq": "2610036D13Rik; Tti1", "protein_names_uniprotkb": "TELO2-interacting protein 1 homolog", "protein_names_refseq": "TEL2-interacting protein 1 homolog; TELO2-interacting protein 1 homolog; Tel2 interacting protein 1 homolog", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:75425)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "11471062;18299400;19224205;20173027;20484733;21750661;21952136;22872234;24657168;25428506;25605945;30084848;30779550;31219806;34203471;34428180;35820727;36210013", "class_list": "", "function": "IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program. Erratum:[Mol Cell. 2020 Aug 20;79(4):702. doi: 10.1016/j.molcel.2020.07.021. PMID: 32822581], [RefSeq, PubMed]; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TS79;Q9CSY0", "ec_number_list": [], "go_molecular_function": "GO:0019900 kinase binding;GO:0140777 protein-containing complex stabilizing activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031931 TORC1 complex;GO:0031932 TORC2 complex;GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "GO:0032006 regulation of TOR signaling;GO:2000003 positive regulation of DNA damage checkpoint", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q91V83-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07607-1", "uniprot_id": [ { "id": "TYSY_MOUSE", "url": "https://www.uniprot.org/uniprot/P07607", "type": "external" } ], "mass": 34958.0, "length": 307, "protein_name": "Thymidylate synthase", "gene_name": "Tyms", "organism": "Mouse", "refseq_name": "thymidylate synthase", "refseq_ac": [ { "id": "NP_067263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067263", "type": "external" } ], "gene_names_uniprotkb": "Tyms", "gene_names_refseq": "Ts; Tyms", "protein_names_uniprotkb": "Thymidylate synthase; 2.1.1.45; TSase; TS", "protein_names_refseq": "Tsase; thymidylate synthase", "tax_id": 10090, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); digenic dyskeratosis congenita (Disease Ontology:DOID:0060984); urinary bladder cancer (Disease Ontology:DOID:11054); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (mmu:22171); (R-MMU-499943)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "21750661;28135057;28528544;2915925;31219806;31599954;33800923;3444407;37106126;3782103", "class_list": "", "function": "Advanced Spectroscopy and APBS Modeling for Determination of the Role of His190 and Trp103 in Mouse Thymidylate Synthase Interaction with Selected dUMP Analogues. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway., [UniProtKB, UniProtKB]; TYMS promotes genomic instability and tumor progression in Ink4a/Arf null background., [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0004799 thymidylate synthase activity;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006231 dTMP biosynthetic process;GO:0006417 regulation of translation;GO:0006260 DNA replication;GO:0017148 negative regulation of translation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07607-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BJU2-1", "uniprot_id": [ { "id": "TSN9_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BJU2", "type": "external" } ], "mass": 26738.0, "length": 239, "protein_name": "Tetraspanin-9", "gene_name": "Tspan9", "organism": "Mouse", "refseq_name": "tetraspanin-9 isoform b", "refseq_ac": [ { "id": "NP_780623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780623", "type": "external" } ], "gene_names_uniprotkb": "Tspan9; Net5", "gene_names_refseq": "6720474K14Rik; 9430079M16Rik; Tspan-9; Tspan9", "protein_names_uniprotkb": "Tetraspanin-9; Tetraspan NET-5; Tspan-9", "protein_names_refseq": "tetraspan NET-5; tetraspanin-9 isoform b", "tax_id": 10090, "disease": "", "pathway": " (mmu:109246)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10.1101/2023.09.13.557529;18795891;18799160;21750661;25428506;28032533;30084848", "class_list": "", "function": "Tetraspanin CD9 has a role in determining vascular smooth muscle cell injury phenotypes, [RefSeq, PubMed]; Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9696, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3TQQ0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0097197 tetraspanin-enriched microdomain;GO:0140494 migrasome", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation;GO:0070527 platelet aggregation;GO:0001780 neutrophil homeostasis;GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8BJU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ44-1", "uniprot_id": [ { "id": "V1R41_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9EQ44", "type": "external" } ], "mass": 35228.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 41", "gene_name": "Vmn1r41", "organism": "Mouse", "refseq_name": "vomeronasal type-1 receptor 41", "refseq_ac": [ { "id": "NP_444460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444460", "type": "external" } ], "gene_names_uniprotkb": "Vmn1r41; V1ra12; V1rb9", "gene_names_refseq": "V1ra12; V1rb9; Vmn1r41", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 41; Vomeronasal type-1 receptor A12; Vomeronasal type-1 receptor B9", "protein_names_refseq": "vomernasal 1 receptor Vmn1r41; vomeronasal receptor 1 A12; vomeronasal type-1 receptor 41; vomeronasal type-1 receptor B9", "tax_id": 10090, "disease": "", "pathway": " (mmu:113857)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11116090;12214233;21750661", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social and reproductive behavior., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIC4", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQ44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50637-1", "uniprot_id": [ { "id": "TSPO_MOUSE", "url": "https://www.uniprot.org/uniprot/P50637", "type": "external" } ], "mass": 18841.0, "length": 169, "protein_name": "Translocator protein", "gene_name": "Tspo", "organism": "Mouse", "refseq_name": "translocator protein", "refseq_ac": [ { "id": "NP_033905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033905", "type": "external" } ], "gene_names_uniprotkb": "Tspo; Bzrp; Mbr", "gene_names_refseq": "Bzrp; IBP; PBR; Tspo1; Tspo", "protein_names_uniprotkb": "Translocator protein; Mitochondrial benzodiazepine receptor; PBR; PKBS; Peripheral-type benzodiazepine receptor", "protein_names_refseq": "PKBS; benzodiazepine receptor, peripheral; isoquinoline-binding protein; mitochondrial benzodiazepine receptor; peripheral-type benzodiazepine receptor; translocator protein", "tax_id": 10090, "disease": "cholesterol ester storage disease (Disease Ontology:DOID:14502)", "pathway": " (mmu:12257); (R-MMU-196108)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11471062;21750661;24174323;24653034;24814875;24936060;25974690;26740625;34428180;38159656;38301966;38482552;7721091;8114671;8125973;9832438", "class_list": "", "function": "Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; FGF1[DeltaHBS] ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model., [RefSeq, PubMed]; Regulation of astrocyte metabolism by mitochondrial translocator protein 18 kDa., [RefSeq, PubMed]; TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q541E3;Q62118;Q6LCZ0;Q99M32", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005497 androgen binding;GO:0008503 benzodiazepine receptor activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1901525 negative regulation of mitophagy;GO:0071476 cellular hypotonic response;GO:0060242 contact inhibition;GO:0060252 positive regulation of glial cell proliferation;GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P50637-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BGV4-1", "uniprot_id": [ { "id": "TTI2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BGV4", "type": "external" } ], "mass": 56702.0, "length": 512, "protein_name": "TELO2-interacting protein 2", "gene_name": "Tti2", "organism": "Mouse", "refseq_name": "TELO2-interacting protein 2 isoform a", "refseq_ac": [ { "id": "NP_659176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659176", "type": "external" } ], "gene_names_uniprotkb": "Tti2", "gene_names_refseq": "Tti2", "protein_names_uniprotkb": "TELO2-interacting protein 2", "protein_names_refseq": "TELO2-interacting protein 2 isoform a", "tax_id": 10090, "disease": "autosomal recessive intellectual developmental disorder 39 (Disease Ontology:DOID:0081204)", "pathway": " (mmu:234138)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;31219806;34428180", "class_list": "", "function": "Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3UTH3;Q8VE31", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0110078 TTT Hsp90 cochaperone complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BGV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R370-1", "uniprot_id": [ { "id": "USBP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8R370", "type": "external" } ], "mass": 74906.0, "length": 680, "protein_name": "Harmonin-binding protein USHBP1", "gene_name": "Ushbp1", "organism": "Mouse", "refseq_name": "harmonin-binding protein USHBP1", "refseq_ac": [ { "id": "NP_852083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852083", "type": "external" } ], "gene_names_uniprotkb": "Ushbp1", "gene_names_refseq": "2210404N08Rik; 9430064H24; AIEBP; MCC2; Ushbp1", "protein_names_uniprotkb": "Harmonin-binding protein USHBP1; USH1C-binding protein 1; Usher syndrome type-1C protein-binding protein 1", "protein_names_refseq": "AIE-75 binding protein; USH1C-binding protein 1; Usher syndrome 1C binding protein 1; harmonin-binding protein USHBP1; usher syndrome type-1C protein-binding protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:234395)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21750661;34428180", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E9QKT2", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R370-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VC6-1", "uniprot_id": [ { "id": "TSAP1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80VC6", "type": "external" } ], "mass": 32423.0, "length": 287, "protein_name": "tRNA selenocysteine 1-associated protein 1", "gene_name": "Trnau1ap", "organism": "Mouse", "refseq_name": "tRNA selenocysteine 1-associated protein 1", "refseq_ac": [ { "id": "NP_082201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082201", "type": "external" } ], "gene_names_uniprotkb": "Trnau1ap; Secp43; Trspap1", "gene_names_refseq": "1110007F05Rik; Secp43; Trnau1ap; Trspap1; WI1-2643G14.2", "protein_names_uniprotkb": "tRNA selenocysteine 1-associated protein 1; SECp43; tRNA selenocysteine-associated protein 1", "protein_names_refseq": "tRNA selenocysteine 1-associated protein 1; tRNA selenocysteine-associated protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:71787)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16230358;16508009;21750661;26043259;29758194;34428180", "class_list": "", "function": "Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins (PubMed:16230358, PubMed:16508009). Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex (PubMed:16230358, PubMed:16508009). May be involved in the methylation of tRNA(Sec) (PubMed:16230358, PubMed:16508009). Enhances efficiency of selenoproteins synthesis (PubMed:16230358, PubMed:16508009)., [UniProtKB, PubMed, PubMed]; Knockdown of Trnau1ap reduced cell migration and proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling pathway., [RefSeq, PubMed]; SECp43 and SLA have roles in selenoprotein synthesis, [RefSeq, PubMed]; These findings suggest that the targeted domains in the SECp43 protein are not essential for selenoprotein biosynthesis in hepatocytes and neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q05DN9;Q4FZE9;Q7TMM7", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q80VC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4Q9F3-1", "uniprot_id": [ { "id": "TTL10_MOUSE", "url": "https://www.uniprot.org/uniprot/A4Q9F3", "type": "external" } ], "mass": 79250.0, "length": 704, "protein_name": "Protein polyglycylase TTLL10", "gene_name": "Ttll10", "organism": "Mouse", "refseq_name": "protein polyglycylase TTLL10 isoform 1", "refseq_ac": [ { "id": "NP_083540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083540", "type": "external" } ], "gene_names_uniprotkb": "Ttll10", "gene_names_refseq": "4833412E22Rik; 4930595O22Rik; Ttll10; Ttll5", "protein_names_uniprotkb": "Protein polyglycylase TTLL10; 6.3.2.-; Tubulin--tyrosine ligase-like protein 10", "protein_names_refseq": "protein polyglycylase TTLL10 isoform 1; protein polyglycylase TTLL10; tubulin tyrosine ligase-like family, member 5; tubulin--tyrosine ligase-like protein 10", "tax_id": 10090, "disease": "", "pathway": " (mmu:330010); (R-MMU-8955332)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17499049;18331838;19427864;19524510;21750661", "class_list": "", "function": "Polyglycylase which modifies both tubulin and non-tubulin proteins, generating polyglycine side chains of variable lengths on the gamma-carboxyl groups of specific glutamate residues of target proteins (PubMed:18331838, PubMed:19427864, PubMed:19524510). Involved in the elongation step rather than the initiation step of the polyglycylation reaction (PubMed:18331838, PubMed:19427864, PubMed:19524510). Polyglycylates alpha-tubulin and beta-tubulin (PubMed:19427864, PubMed:19524510). Polyglycylates non-tubulin proteins such as nucleosome assembly protein NAP1 (PubMed:18331838)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Recombinant TTLL10 incorporated glycine into recombinant nucleosome assembly protein 1 in vitro. GeneRIF: has a polyglycylase (i.e. glycine ligase) activity for nucleosome assembly protein 1 (NAP1)., [RefSeq, PubMed]; TTLL10 can strongly glycylate tubulin in a TTLL8-dependent manner. Furthermore, these two TTLL proteins can glycylate unidentified 170-, 110-, 75-, 40-, 35-, and 30-kDa acidic proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3V0K4", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0070735 protein-glycine ligase activity;GO:0070737 protein-glycine ligase activity, elongating", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton;GO:0005930 axoneme", "go_biological_process": "GO:0018094 protein polyglycylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A4Q9F3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V51-1", "uniprot_id": [ { "id": "TTLL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q91V51", "type": "external" } ], "mass": 49110.0, "length": 423, "protein_name": "Polyglutamylase complex subunit TTLL1", "gene_name": "Ttll1", "organism": "Mouse", "refseq_name": "polyglutamylase complex subunit TTLL1", "refseq_ac": [ { "id": "NP_849200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849200", "type": "external" } ], "gene_names_uniprotkb": "Ttll1", "gene_names_refseq": "6330444E16Rik; Ttll1", "protein_names_uniprotkb": "Polyglutamylase complex subunit TTLL1; 6.3.2.-; PGs3; Tubulin polyglutamylase TTLL1; Tubulin polyglutamylase complex subunit 3; Tubulin--tyrosine ligase-like protein 1; p49", "protein_names_refseq": "PGs3; p49; polyglutamylase complex subunit TTLL1; probable tubulin polyglutamylase TTLL1; tubulin polyglutamylase complex subunit 3; tubulin--tyrosine ligase-like protein 1", "tax_id": 10090, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (mmu:319953)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "15890843;17499049;20442420;20498047;21750661;22170066;23897886;29593216;34428180;37238654", "class_list": "", "function": "Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:15890843). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step (Probable). Modifies both alpha- and beta-tubulins with a preference for the alpha-tail (PubMed:15890843, PubMed:22170066). Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity (PubMed:15890843). Part of the neuronal tubulin polyglutamylase complex (PubMed:15890843). Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:20442420, PubMed:20498047, PubMed:23897886). Involved in respiratory motile cilia function through the regulation of beating asymmetry (PubMed:20442420, PubMed:20498047). Essential for sperm flagella biogenesis, motility and male fertility (PubMed:20442420). Also mediates glutamylation of non-tubulin proteins (PubMed:29593216). Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Findings showed that the neuronal tubulin polyglutamylase is a protein complex containing a tubulin tyrosine ligase-like (TTLL) protein, TTLL1, [RefSeq, PubMed]; Loss of beating asymmetry resulted in a reduction of cilia-generated fluid flow in trachea from the Ttll1 knock-out mice., [RefSeq, PubMed]; TTLL1 plays a role in establishing normal functions of specific cilia and flagella., [RefSeq, PubMed]; Tubulin Polyglutamylation by TTLL1 and TTLL7 Regulate Glutamate Concentration in the Mice Brain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TGC8;Q543S4;Q8C0A2;Q91ZG1", "ec_number_list": [ { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0070740 tubulin-glutamic acid ligase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0106438 protein-glutamic acid ligase activity, elongating", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005874 microtubule;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0000226 microtubule cytoskeleton organization;GO:0021702 cerebellar Purkinje cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q91V51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1AY15-1", "uniprot_id": [ { "id": "UBP51_MOUSE", "url": "https://www.uniprot.org/uniprot/B1AY15", "type": "external" } ], "mass": 74783.0, "length": 661, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 51", "gene_name": "Usp51", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 51", "refseq_ac": [ { "id": "NP_001131019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131019", "type": "external" } ], "gene_names_uniprotkb": "Usp51", "gene_names_refseq": "Usp51", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 51; 3.4.19.12; Deubiquitinating enzyme 51", "protein_names_refseq": "deubiquitinating enzyme 51; ubiquitin carboxyl-terminal hydrolase 51; ubiquitin specific peptidase 51", "tax_id": 10090, "disease": "glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (mmu:635253)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "25605945;27083998;30779550", "class_list": "", "function": "Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 (PubMed:27083998). Functions in DNA double-strand break repair also by mediating the deubiquitination and subsequent stabilization of DGCR8, leading to the recruitment of DGCR8 binding partners to double strand breaks such as RNF168 or MDC1. In addition, promotes the deubiquitination and stabilization of the transcriptional repressor ZEB1., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0140950 histone H2A deubiquitinase activity", "go_cellular_component": "GO:0005694 chromosome", "go_biological_process": "GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0006974 DNA damage response;GO:0010564 regulation of cell cycle process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1AY15-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97343-1", "uniprot_id": [ { "id": "UHMK1_MOUSE", "url": "https://www.uniprot.org/uniprot/P97343", "type": "external" } ], "mass": 46489.0, "length": 419, "protein_name": "Serine/threonine-protein kinase Kist", "gene_name": "Uhmk1", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase Kist isoform 1", "refseq_ac": [ { "id": "NP_034763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_034763", "type": "external" } ], "gene_names_uniprotkb": "Uhmk1; Kist; Kis", "gene_names_refseq": "4732477C12Rik; 4930500M09Rik; C820018A03Rik; KIS; Kist; P-CIP2; Uhmk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Kist; 2.7.11.1; Kinase interacting with stathmin; P-CIP2; PAM COOH-terminal interactor protein 2; U2AF homology motif kinase 1", "protein_names_refseq": "PAM COOH-terminal interactor protein 2; U2AF homology motif kinase 1; kinase interacting with leukemia-associated gene (stathmin); kinase interacting with stathmin; serine/threonine-protein kinase Kist isoform 1; serine/threonine-protein kinase Kist", "tax_id": 10090, "disease": "", "pathway": " (mmu:16589); (R-MMU-9634638)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12093740;21750661;25319695;25428506;30084848;31219806;31975428;34428180;36210013;38597390;7724523;9287318", "class_list": "", "function": "Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced., [RefSeq, PubMed]; KIS counteracts PTBP2 and regulates alternative exon usage in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines., [RefSeq, PubMed]; UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism., [RefSeq, PubMed]; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q61775;Q9CYT1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030424 axon;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0031175 neuron projection development;GO:0018105 peptidyl-serine phosphorylation;GO:0046825 regulation of protein export from nucleus;GO:0051726 regulation of cell cycle;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97343-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62080-1", "uniprot_id": [ { "id": "TSN5_MOUSE", "url": "https://www.uniprot.org/uniprot/P62080", "type": "external" } ], "mass": 30337.0, "length": 268, "protein_name": "Tetraspanin-5", "gene_name": "Tspan5", "organism": "Mouse", "refseq_name": "tetraspanin-5 isoform 1", "refseq_ac": [ { "id": "NP_062517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062517", "type": "external" } ], "gene_names_uniprotkb": "Tspan5; Tm4sf9", "gene_names_refseq": "2810455A09Rik; 4930505M03Rik; NET-4; Tm4sf9; Tspan5", "protein_names_uniprotkb": "Tetraspanin-5; Tetraspan NET-4; Transmembrane 4 superfamily member 9; Tspan-5", "protein_names_refseq": "tetraspan NET-4; tetraspanin Tspan-5; tetraspanin-5 isoform 1; transmembrane 4 superfamily member 9", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (mmu:56224)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11472858;21750661;23035126;24935633;26668317;28428248;31219806;36215490", "class_list": "", "function": "Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44. Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulates ADAM10 maturation and trafficking to the cell surface (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44 (By similarity)., [UniProtKB, UniProtKB]; Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation., [RefSeq, PubMed]; This protein is expressed during brain development from embryonic stages to adulthood., [RefSeq, PubMed]; Tspan-5 and Tspan-10, are up-regulated during osteoclast differentiation and knockdown of their expression dramatically inhibits osteoclastogenesis, [RefSeq, PubMed]; Two TspanC8-specific motifs in the large extracellular domain of Tspan5 that are important for ADAM10 interaction and exit from the endoplasmic reticulum. One of the anti-Tspan5 mAbs does not recognize Tspan5 associated with ADAM10, providing a convenient way to measure the fraction of Tspan5 not associated with ADAM10., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O60628;O60746;Q9JLY1", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0045747 positive regulation of Notch signaling pathway;GO:0051604 protein maturation;GO:0051043 regulation of membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P62080-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70475-1", "uniprot_id": [ { "id": "UGDH_MOUSE", "url": "https://www.uniprot.org/uniprot/O70475", "type": "external" } ], "mass": 54832.0, "length": 493, "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "Ugdh", "organism": "Mouse", "refseq_name": "UDP-glucose 6-dehydrogenase", "refseq_ac": [ { "id": "NP_033492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033492", "type": "external" } ], "gene_names_uniprotkb": "Ugdh", "gene_names_refseq": "Udpgdh; Ugdh", "protein_names_uniprotkb": "UDP-glucose 6-dehydrogenase; 1.1.1.22; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH", "protein_names_refseq": "UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase", "tax_id": 10090, "disease": "developmental and epileptic encephalopathy 84 (Disease Ontology:DOID:0112219)", "pathway": " (mmu:22235); (R-MMU-173599)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "14505572;17242355;18630941;19131326;21183079;21750661;23806337;34428180;34887587;37169760;37453647;37828378;37858159;38367236;9737970", "class_list": "glycogene", "function": "Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:9737970). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (PubMed:14505572). Required for proper brain and neuronal development (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis., [RefSeq, PubMed]; UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis. Publication Status: Online-Only, [RefSeq, PubMed]; UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 19, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001702 gastrulation with mouth forming second;GO:0006024 glycosaminoglycan biosynthetic process;GO:0048666 neuron development;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O70475-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.0100000001001.001.10000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25688-1", "uniprot_id": [ { "id": "URIC_MOUSE", "url": "https://www.uniprot.org/uniprot/P25688", "type": "external" } ], "mass": 35039.0, "length": 303, "protein_name": "Uricase", "gene_name": "Uox", "organism": "Mouse", "refseq_name": "uricase", "refseq_ac": [ { "id": "NP_033500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033500", "type": "external" } ], "gene_names_uniprotkb": "Uox", "gene_names_refseq": "Uox", "protein_names_uniprotkb": "Uricase; 1.7.3.3; Urate oxidase", "protein_names_refseq": "uricase", "tax_id": 10090, "disease": "nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); gout (Disease Ontology:DOID:13189); hyperuricemia (Disease Ontology:DOID:1920)", "pathway": " (mmu:22262)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "17208939;17242355;21183079;21750661;23085393;23576753;23806337;2594778;30084848;34428180;37453647", "class_list": "", "function": "Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.3.3", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0004846 urate oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006145 purine nucleobase catabolic process;GO:0019628 urate catabolic process;GO:0006154 adenosine catabolic process;GO:0006157 deoxyadenosine catabolic process;GO:0006196 AMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P25688-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BX13-1", "uniprot_id": [ { "id": "UBE3D_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BX13", "type": "external" } ], "mass": 40753.0, "length": 368, "protein_name": "E3 ubiquitin-protein ligase E3D", "gene_name": "Ube3d", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase E3D isoform 1", "refseq_ac": [ { "id": "NP_081670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081670", "type": "external" } ], "gene_names_uniprotkb": "Ube3d; H10bh; Ube2cbp", "gene_names_refseq": "2610018I03Rik; Ube2cbp; Ube3d", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase E3D; 2.3.2.26; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein", "protein_names_refseq": "E3 ubiquitin-protein ligase E3D isoform 1; E3 ubiquitin-protein ligase E3D; HECT-type E3 ubiquitin transferase E3D; UbcH10 binding protein with a hect-like domain; ubcH10-binding protein with a HECT-like domain; ubiquitin-conjugating enzyme E2C binding protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:70348); (R-MMU-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21750661;25872646;36094642;36519931;37772657", "class_list": "", "function": "Ablation of the UBE3D protein lead to an abnormal amount of pigment granules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretinography (ERG) in UBE3D(+/-) heterozygous mice. Publication Status: Online-Only, [RefSeq, PubMed]; Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair., [RefSeq, PubMed]; UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0008428 ribonuclease inhibitor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8BX13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13439-1", "uniprot_id": [ { "id": "UMPS_MOUSE", "url": "https://www.uniprot.org/uniprot/P13439", "type": "external" } ], "mass": 52292.0, "length": 481, "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "Umps", "organism": "Mouse", "refseq_name": "uridine 5'-monophosphate synthase isoform 1", "refseq_ac": [ { "id": "NP_033497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033497", "type": "external" } ], "gene_names_uniprotkb": "Umps", "gene_names_refseq": "1700095D23Rik; Umps", "protein_names_uniprotkb": "Uridine 5'-monophosphate synthase; OMPdecase; UMP synthase", "protein_names_refseq": "UMP synthase; uridine 5'-monophosphate synthase isoform 1; uridine 5'-monophosphate synthase", "tax_id": 10090, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (mmu:22247); (R-MMU-500753)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21750661;22645316;2419341;24788674;27802388;30084848;30779550;31599954;34428180", "class_list": "", "function": "Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99L26", "ec_number_list": [ { "id": "2.4.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.10", "type": "external" }, { "id": "4.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.23", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004588 orotate phosphoribosyltransferase activity;GO:0004590 orotidine-5'-phosphate decarboxylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006222 UMP biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13439-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00993-1", "uniprot_id": [ { "id": "UFO_MOUSE", "url": "https://www.uniprot.org/uniprot/Q00993", "type": "external" } ], "mass": 98191.0, "length": 888, "protein_name": "Tyrosine-protein kinase receptor UFO", "gene_name": "Axl", "organism": "Mouse", "refseq_name": "tyrosine-protein kinase receptor UFO isoform 1 precursor", "refseq_ac": [ { "id": "NP_033491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033491", "type": "external" } ], "gene_names_uniprotkb": "Axl; Ark; Ufo", "gene_names_refseq": "Ark; Axl; Tyro7; Ufo", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor UFO; 2.7.10.1; Adhesion-related kinase", "protein_names_refseq": "adhesion-related kinase; tyrosine-protein kinase receptor UFO isoform 1 precursor; tyrosine-protein kinase receptor UFO; ufo oncogene homolog", "tax_id": 10090, "disease": "glomerulonephritis (Disease Ontology:DOID:2921); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:26362); (R-MMU-4420097)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10.1101/2023.09.13.557529;1320243;18083102;1840679;20363878;21750661;27780404;31219806;31599954;34428180;37828378;7867073", "class_list": "", "function": "Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9507, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q80YQ3", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0015629 actin cytoskeleton;GO:0043235 receptor complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0035457 cellular response to interferon-alpha;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:2000669 negative regulation of dendritic cell apoptotic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q00993-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1Q9-1", "uniprot_id": [ { "id": "VAS1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q9R1Q9", "type": "external" } ], "mass": 51008.0, "length": 463, "protein_name": "V-type proton ATPase subunit S1", "gene_name": "Atp6ap1", "organism": "Mouse", "refseq_name": "V-type proton ATPase subunit S1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_061264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061264", "type": "external" } ], "gene_names_uniprotkb": "Atp6ap1; Atp6ip1; Atp6s1", "gene_names_refseq": "16A; AC45; Atp6ap1; Atp6ip1; Atp6s1; C7-1; CF2; VATPS1; XAP-3; mFLJ00383", "protein_names_uniprotkb": "V-type proton ATPase subunit S1; Protein C7-1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; Vacuolar proton pump subunit S1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal interacting protein 1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; V-type proton ATPase subunit S1 isoform 1 precursor; V-type proton ATPase subunit S1; protein C7-1; vacuolar H+ ATPase accessory subunit 1; vacuolar proton pump subunit S1", "tax_id": 10090, "disease": "immunodeficiency 47 (Disease Ontology:DOID:0112002)", "pathway": " (mmu:54411); (R-MMU-77387); (R-MMU-8980692); (R-MMU-917977); (R-MMU-983712)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10.1101/2023.09.13.557529;11989824;16901940;17114649;18227071;18713856;19349973;21750661;25428506;26495903;27231034;28011936;30084848;30317586;30899004;32045577;33077625;33300544;34428180;35197629;35984892;37828378", "class_list": "", "function": "Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:18713856). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:35197629). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (By similarity). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (By similarity). May play a role in the assembly of the V-type ATPase complex (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (PubMed:18713856)., [UniProtKB, UniProtKB, PubMed, PubMed]; Cytoplasmic terminus of Ac45 contains elements necessary for its proper interaction with V(0) domain and efficient osteoclastic bone resorption, [RefSeq, PubMed]; In osteoclasts, the activity-dependent accumulation of acids and Ca(2+) in the closed extracellular compartment might serve as negative feedback signals for regulating the V-ATPase., [RefSeq, PubMed]; Peptidylglycine alpha-amidating mono-oxygenase serves as a luminal pH-sensor, regulating V-ATPase action by altering its assembly status in peptidergic cells., [RefSeq, PubMed]; Silencing of Ac45 Simultaneously Inhibits Osteoclast-Mediated Bone Resorption and Attenuates Dendritic Cell-Mediated Inflammation through Impairing Acidification and Cathepsin K Secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted disruption of the gene for the chromaffin granular V-ATPase-associated protein Ac45 in embryonic stem cells affects the normal blastocyst development, suggesting an essential role for the V-ATPase in early embryonic development. [AC45], [RefSeq, PubMed]; V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 14, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036035 osteoclast development;GO:0030641 regulation of cellular pH;GO:0036295 cellular response to increased oxygen levels;GO:0099638 endosome to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 4.6, "record_id": "Q9R1Q9-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P5E4-1", "uniprot_id": [ { "id": "UGGG1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P5E4", "type": "external" } ], "mass": 176434.0, "length": 1551, "protein_name": "UDP-glucose:glycoprotein glucosyltransferase 1", "gene_name": "Uggt1", "organism": "Mouse", "refseq_name": "UDP-glucose:glycoprotein glucosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_942602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942602", "type": "external" } ], "gene_names_uniprotkb": "Uggt1; Gt; Ugcgl1; Uggt; Ugt1; Ugtr", "gene_names_refseq": "0910001L17Rik; A930007H10Rik; C820010P03Rik; GT; UGT1; Ugcgl1; Uggt1", "protein_names_uniprotkb": "UDP-glucose:glycoprotein glucosyltransferase 1; 2.4.1.-; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UGT1", "protein_names_refseq": "UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose:glycoprotein glucosyltransferase 1 precursor; UDP-glucose:glycoprotein glucosyltransferase", "tax_id": 10090, "disease": "", "pathway": " (mmu:320011)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10.1101/2023.09.13.557529;11278576;16129668;21750661;25428506;26740625;28135057;28545059;30059200;30084848;30899004;32423812;34428180;34678516;34887587;35613513;37828378;39627609;40997131", "class_list": "glycogene;glycosyltransferase", "function": "Increased UGGT1 levels elevated viral growth rates, while viral pathogenicity was observed to be lower in heterozygous knockout mice (Uggt1 +/- mice). These findings provide important insight on the role of UPR and host UGGT1 in regulating RNA virus replication and pathogenicity. Publication Status: Online-Only, [RefSeq, PubMed]; R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding., [RefSeq, PubMed]; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity)., [UniProtKB]; The cysteine-rich domain of Sep15 exclusively mediates protein-protein interactions with UDP-glucose:glycoprotein glucosyltransferase., [RefSeq, PubMed]; UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 81, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "E9QQ49;Q6NV70", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q6P5E4-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1100000010001.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3V3E1-1", "uniprot_id": [ { "id": "UBS3A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3V3E1", "type": "external" } ], "mass": 70145.0, "length": 624, "protein_name": "Ubiquitin-associated and SH3 domain-containing protein A", "gene_name": "Ubash3a", "organism": "Mouse", "refseq_name": "ubiquitin-associated and SH3 domain-containing protein A", "refseq_ac": [ { "id": "NP_808491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808491", "type": "external" } ], "gene_names_uniprotkb": "Ubash3a; Sts2", "gene_names_refseq": "5830413C03Rik; C330001M22; Sts-2; TULA-1; TULA; Ubash3a", "protein_names_uniprotkb": "Ubiquitin-associated and SH3 domain-containing protein A; STS-2; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1; TULA-1", "protein_names_refseq": "T-cell ubiquitin ligand 1; suppressor of T-cell receptor signaling 2; ubiquitin-associated and SH3 domain-containing protein A", "tax_id": 10090, "disease": "", "pathway": " (mmu:328795)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19196006;20670933;21750661;30084848;32694640;35820727", "class_list": "", "function": "Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligible protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation., [UniProtKB, PubMed]; UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3TED7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005634 nucleus", "go_biological_process": "GO:0001817 regulation of cytokine production;GO:0050860 negative regulation of T cell receptor signaling pathway;GO:0002683 negative regulation of immune system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3V3E1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3UP75-1", "uniprot_id": [ { "id": "UD3A1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3UP75", "type": "external" } ], "mass": 59698.0, "length": 523, "protein_name": "UDP-glycosyltransferase 3A1", "gene_name": "Ugt3a1; Ugt3a2", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 3A1 precursor", "refseq_ac": [ { "id": "NP_997099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997099", "type": "external" } ], "gene_names_uniprotkb": "Ugt3a1; Ugt3a2; Ugt3a1", "gene_names_refseq": "Ugt3a1; Ugt3a2; Ugt3a", "protein_names_uniprotkb": "UDP-glycosyltransferase 3A1; 2.4.1.170; UDP-glucosyltransferase 3A1; UDPGT 3A1", "protein_names_refseq": "UDP glucuronosyltransferase 3 family, polypeptide A1; UDP glycosyltransferases 3 family, polypeptide A1; UDP-glucuronosyltransferase 3A1 precursor; UDP-glucuronosyltransferase 3A1; UDPGT 3A1", "tax_id": 10090, "disease": "", "pathway": " (mmu:105887); (R-MMU-156588); (R-MMU-9749641)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "17050650;21750661;22621930;30084848;34428180;35820727;40997131", "class_list": "glycogene;glycosyltransferase", "function": "Involved in biotransformation reactions in which lipophilic substrates are conjugated with sugars to increase water solubility and enhance excretion. Such reactions are of major importance in the elimination of potentially toxic xenobiotics and endogenous compounds. It catalyzes the transfer of sugar from UDP-glucose to the bile acid ursodeoxycholic acid (UDCA), while is inactive with UDP-N-acetylglucosamine as sugar donor (PubMed:22621930). Is also inactive with UDP-glucuronic acid (By similarity). In addition to UDCA, it can use 4-methylumbelliferone as sugar acceptor (PubMed:22621930). To a lesser extent, is able to transfer the sugar residue to 17alpha-estradiol, 17beta-estradiol, 4-nitrophenol, 1-naphtol and genistein (By similarity). Has negligible activity, if any, toward cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, and hyodeoxycholic acid (By similarity)., [UniProtKB, UniProtKB, PubMed]; Mouse Ugt3a1 was active with 4-methylumbelliferone and ursodeoxycholic acid using UDP-Glc as the sugar donor. However, it showed no activity toward either substrate with UDP-GlcNAc., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 53, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R0Y5", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0043541 UDP-N-acetylglucosamine transferase complex", "go_biological_process": "GO:0071412 cellular response to genistein", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q3UP75-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J3S6Y1-1", "uniprot_id": [ { "id": "TSEAR_MOUSE", "url": "https://www.uniprot.org/uniprot/J3S6Y1", "type": "external" } ], "mass": 75098.0, "length": 670, "protein_name": "Thrombospondin-type laminin G domain and EAR repeat-containing protein", "gene_name": "Tspear", "organism": "Mouse", "refseq_name": "thrombospondin-type laminin G domain and EAR repeat-containing protein precursor", "refseq_ac": [ { "id": "NP_001274003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274003", "type": "external" } ], "gene_names_uniprotkb": "Tspear; Tnep1", "gene_names_refseq": "C330046G03Rik; ORF65; TSP-EAR; Tnep1; Tspear", "protein_names_uniprotkb": "Thrombospondin-type laminin G domain and EAR repeat-containing protein; TSP-EAR", "protein_names_refseq": "thrombospondin N-terminal domain/EPTP protein 1; thrombospondin-type laminin G domain and EAR repeat-containing protein precursor; thrombospondin-type laminin G domain and EAR repeat-containing protein; thrombospondin-type laminin G domain and EAR repeats protein", "tax_id": 10090, "disease": "tooth agenesis (Disease Ontology:DOID:0050591); autosomal recessive nonsyndromic deafness 98 (Disease Ontology:DOID:0110540); ectodermal dysplasia 14 (Disease Ontology:DOID:0111662)", "pathway": " (mmu:252974)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12217514;22678063;27736875;37009414", "class_list": "", "function": "Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system., [UniProtKB, UniProtKB]; TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice., [RefSeq, PubMed]; Using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8BUQ8;Q8K4Y9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0060170 ciliary membrane;GO:0032420 stereocilium", "go_biological_process": "GO:0007165 signal transduction;GO:0007219 Notch signaling pathway;GO:0007605 sensory perception of sound;GO:0034505 tooth mineralization;GO:0022405 hair cycle process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "J3S6Y1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08859-1", "uniprot_id": [ { "id": "TSG6_MOUSE", "url": "https://www.uniprot.org/uniprot/O08859", "type": "external" } ], "mass": 30924.0, "length": 275, "protein_name": "Tumor necrosis factor-inducible gene 6 protein", "gene_name": "Tnfaip6", "organism": "Mouse", "refseq_name": "tumor necrosis factor-inducible gene 6 protein precursor", "refseq_ac": [ { "id": "NP_033424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033424", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip6; Tnfip6; Tsg6", "gene_names_refseq": "TSG-6; Tnfaip6; Tnfip6; Tsg6", "protein_names_uniprotkb": "Tumor necrosis factor-inducible gene 6 protein; TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6", "protein_names_refseq": "TNF alpha-induced protein 6; TNF-stimulated gene 6 protein; tumor necrosis factor induced protein 6; tumor necrosis factor-inducible gene 6 protein precursor; tumor necrosis factor-inducible gene 6 protein", "tax_id": 10090, "disease": "corneal neovascularization (Disease Ontology:DOID:11382); atopic dermatitis (Disease Ontology:DOID:3310); conjunctival disease (Disease Ontology:DOID:4251)", "pathway": " (mmu:21930); (R-MMU-6798695)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "12011075;12586778;12668637;12959984;18586671;25428507;34428180;35820727;37391162;38151073;38569926;9427551", "class_list": "", "function": "Cells expressing CD44/TSG-6 failed to roll on hyaluronan, instead, they stuck and remained 'tethered' to the substrate under fluid flow, [RefSeq, PubMed]; Endogenous TSG-6 modulates corneal inflammation following chemical injury., [RefSeq, PubMed]; Major regulator of extracellular matrix organization during tissue remodeling (By similarity). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (By similarity). Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed:12668637). Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (By similarity). Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (By similarity). Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (By similarity) (PubMed:18586671)., [UniProtKB, PubMed, PubMed, UniProtKB]; Observations identify tumor necrosis factor-alpha-stimulated gene 6 as a target of prostaglandin action and show that its production in ovulatory follicles is associated with proper formation of the cumulus-derived extracellular matrix, [RefSeq, PubMed]; Results provide clear evidence that TNFIP6 is a key catalyst in the formation of the cumulus extracellular matrix and indispensable for female fertility, [RefSeq, PubMed]; TSG-6 mRNA is induced in cumulus cells in culture by cAMP and that the secreted TSG-6 protein is a key structural component of the mouse cumulus cell-oocyte complex matrix., [RefSeq, PubMed]; TSG-6-Mediated Extracellular Matrix Modifications Regulate Hypoxic-Ischemic Brain Injury. Publication Status: Online-Only, [RefSeq, PubMed]; TSG6 hyaluronan matrix remodeling dampens the inflammatory response during colitis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0001968 fibronectin binding;GO:0005540 hyaluronic acid binding;GO:0106435 carboxylesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:1903911 positive regulation of receptor clustering;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0050728 negative regulation of inflammatory response;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08859-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07309-1", "uniprot_id": [ { "id": "TTHY_MOUSE", "url": "https://www.uniprot.org/uniprot/P07309", "type": "external" } ], "mass": 15776.0, "length": 147, "protein_name": "Transthyretin", "gene_name": "Ttr", "organism": "Mouse", "refseq_name": "transthyretin precursor", "refseq_ac": [ { "id": "NP_038725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038725", "type": "external" } ], "gene_names_uniprotkb": "Ttr", "gene_names_refseq": "Ttr; prealbumin", "protein_names_uniprotkb": "Transthyretin; Prealbumin", "protein_names_refseq": "transthyretin precursor", "tax_id": 10090, "disease": "hereditary systemic amyloidosis 1 (Disease Ontology:DOID:0050638); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); carpal tunnel syndrome 1 (Disease Ontology:DOID:0070466); dystransthyretinemic hyperthyroxinemia (Disease Ontology:DOID:0080219); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); lung cancer (Disease Ontology:DOID:1324); brain ischemia (Disease Ontology:DOID:2316); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); amyloidosis (Disease Ontology:DOID:9120); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (mmu:22139); (R-MMU-2453902); (R-MMU-6798695); (R-MMU-975634)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10.1101/2023.09.13.557529;17330941;18006495;26495903;28011936;3005251;3020014;34428180;36288343;37507081;39627609", "class_list": "", "function": "This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]., [RefSeq]; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042562 hormone binding;GO:0044877 protein-containing complex binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P07309-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17717-1", "uniprot_id": [ { "id": "UDB17_MOUSE", "url": "https://www.uniprot.org/uniprot/P17717", "type": "external" } ], "mass": 60856.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B17", "gene_name": "Ugt2b17", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt2b17; Ugt2b5", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B17; 2.4.1.17; M-1; UDP-glucuronosyltransferase 2B5; UDPGT 2B5; UGT2B17", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (R-MMU-156588); (R-MMU-9749641); (R-MMU-9757110)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10.1101/2023.09.13.557529;29237092;3117546;34428180;37453647", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.1100000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31254-1", "uniprot_id": [ { "id": "UBA1Y_MOUSE", "url": "https://www.uniprot.org/uniprot/P31254", "type": "external" } ], "mass": 118038.0, "length": 1058, "protein_name": "Ubiquitin-like modifier-activating enzyme 1 Y", "gene_name": "Uba1y", "organism": "Mouse", "refseq_name": "ubiquitin-like modifier-activating enzyme 1 Y", "refseq_ac": [ { "id": "NP_001343972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001343972", "type": "external" } ], "gene_names_uniprotkb": "Uba1y; Sby; Ube1ay; Ube1y1; Ube1y", "gene_names_refseq": "A1s9Y-1; Sby; Uba1y; Ube-2; Ube1ay; Ube1y-1; Ube1y1; Ube1y", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 1 Y; 6.2.1.45; Ubiquitin-activating enzyme E1 Y; Ubiquitin-activating enzyme E1", "protein_names_refseq": "ubiquitin-activating enzyme E1 Y; ubiquitin-activating enzyme E1, Chr Y 1; ubiquitin-like modifier-activating enzyme 1 Y", "tax_id": 10090, "disease": "", "pathway": " (mmu:22202)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10656933;1684224;25428506;31219806;7714913;8948595", "class_list": "", "function": "Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q60639;Q8CDH7;Q9QYS4;Q9QZX2", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0004839 ubiquitin activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31254-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35761-1", "uniprot_id": [ { "id": "TTK_MOUSE", "url": "https://www.uniprot.org/uniprot/P35761", "type": "external" } ], "mass": 96211.0, "length": 856, "protein_name": "Dual specificity protein kinase TTK", "gene_name": "Ttk", "organism": "Mouse", "refseq_name": "dual specificity protein kinase TTK isoform 1", "refseq_ac": [ { "id": "NP_033471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033471", "type": "external" } ], "gene_names_uniprotkb": "Ttk; Esk", "gene_names_refseq": "Esk1; Mps1; PYT; Ttk; esk", "protein_names_uniprotkb": "Dual specificity protein kinase TTK; 2.7.12.1; ESK; PYT", "protein_names_refseq": "dual specificity protein kinase TTK isoform 1; dual specificity protein kinase TTK", "tax_id": 10090, "disease": "cancer (Disease Ontology:DOID:162); bipolar disorder (Disease Ontology:DOID:3312); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "1375325;21183079;21750661;22872234;25605945;34428180", "class_list": "", "function": "Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000776 kinetochore", "go_biological_process": "GO:0016321 female meiosis chromosome segregation;GO:0033316 meiotic spindle assembly checkpoint signaling;GO:1903096 protein localization to meiotic spindle midzone;GO:0007059 chromosome segregation;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35761-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38575-1", "uniprot_id": [ { "id": "UPK2_MOUSE", "url": "https://www.uniprot.org/uniprot/P38575", "type": "external" } ], "mass": 19572.0, "length": 184, "protein_name": "Uroplakin-2", "gene_name": "Upk2", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Upk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Uroplakin-2; UP2; UPII; Uroplakin II", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "30084848;30779550;7846036;8175808", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38575-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38640-1", "uniprot_id": [ { "id": "UF02_MOUSE", "url": "https://www.uniprot.org/uniprot/P38640", "type": "external" } ], "mass": 1103.0, "length": 9, "protein_name": "Unknown protein from 2D-PAGE of fibroblasts", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from 2D-PAGE of fibroblasts; P32", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7523108", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38640-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49766-1", "uniprot_id": [ { "id": "VEGFB_MOUSE", "url": "https://www.uniprot.org/uniprot/P49766", "type": "external" } ], "mass": 21914.0, "length": 207, "protein_name": "Vascular endothelial growth factor B", "gene_name": "Vegfb", "organism": "Mouse", "refseq_name": "vascular endothelial growth factor B isoform Vegf-b167 precursor", "refseq_ac": [ { "id": "NP_001172093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001172093", "type": "external" } ], "gene_names_uniprotkb": "Vegfb; Vrf", "gene_names_refseq": "VEGF-B; Vegfb; Vrf", "protein_names_uniprotkb": "Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF", "protein_names_refseq": "VEGF-related factor; vascular endothelial growth factor B isoform Vegf-b167 precursor", "tax_id": 10090, "disease": "retinal vein occlusion (Disease Ontology:DOID:1727); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (mmu:22340); (R-MMU-114608); (R-MMU-194313); (R-MMU-195399)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11457758;8607868;8637916;8702615", "class_list": "", "function": "Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UG04;Q5D0B1;Q64290", "ec_number_list": [], "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0036454 growth factor complex", "go_biological_process": "GO:0035470 positive regulation of vascular wound healing;GO:0007507 heart development;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49766-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50516-1", "uniprot_id": [ { "id": "VATA_MOUSE", "url": "https://www.uniprot.org/uniprot/P50516", "type": "external" } ], "mass": 68326.0, "length": 617, "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "Atp6v1a", "organism": "Mouse", "refseq_name": "V-type proton ATPase catalytic subunit A isoform 1", "refseq_ac": [ { "id": "NP_031534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031534", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1a; Atp6a1; Atp6a2; Atp6v1a1", "gene_names_refseq": "Atp6a1; Atp6a2; Atp6v1a1; Atp6v1a; VA68; VPP2", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A; 7.1.2.2; V-ATPase 69 kDa subunit; V-ATPase subunit A; Vacuolar proton pump subunit alpha", "protein_names_refseq": "70-kDa subunit; ATPase, H+ transporting, V1 subunit A1; ATPase, H+ transporting, V1 subunit A; ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa; ATPase, H+ transporting, lysosomal 70kD, V1 subunit A; V-ATPase 69 kDa subunit; V-ATPase subunit A; V-type proton ATPase catalytic subunit A isoform 1; V-type proton ATPase catalytic subunit A; lysosomal 70kDa; vacuolar proton pump subunit alpha", "tax_id": 10090, "disease": "autosomal recessive cutis laxa type IID (Disease Ontology:DOID:0070129); developmental and epileptic encephalopathy 93 (Disease Ontology:DOID:0112275)", "pathway": " (mmu:11964); (R-MMU-1222556); (R-MMU-77387); (R-MMU-917977); (R-MMU-9639288); (R-MMU-983712)", "pathway_count": 6, "publication_count": 20, "publication_id_list": "10.1101/2023.09.13.557529;11495928;17114649;18034455;21750661;23863464;26740625;28135057;30779550;31219806;31786107;33300544;34428180;35822049;37453647;37507081;37828378;39627609;40885482;8741845", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:23863464). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3TKS0;Q3U5W3;Q3U777;Q3UDZ9;Q3US31;Q8CHX2", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0046034 ATP metabolic process;GO:0036295 cellular response to increased oxygen levels;GO:0097401 synaptic vesicle lumen acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P50516-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.1100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58321-1", "uniprot_id": [ { "id": "UCHL4_MOUSE", "url": "https://www.uniprot.org/uniprot/P58321", "type": "external" } ], "mass": 26450.0, "length": 233, "protein_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L4", "gene_name": "Uchl4", "organism": "Mouse", "refseq_name": "ubiquitin carboxyl-terminal hydrolase isozyme L4", "refseq_ac": [ { "id": "NP_291085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_291085", "type": "external" } ], "gene_names_uniprotkb": "Uchl4", "gene_names_refseq": "Uchl4", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase isozyme L4; 3.4.19.12; UCH-L4; Ubiquitin thioesterase L4", "protein_names_refseq": "UCH-L4; ubiquitin carboxyl-terminal hydrolase isozyme L4; ubiquitin thioesterase L4", "tax_id": 10090, "disease": "late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (mmu:93841)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11341770", "class_list": "", "function": "Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58321-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70675-1", "uniprot_id": [ { "id": "TSX_MOUSE", "url": "https://www.uniprot.org/uniprot/P70675", "type": "external" } ], "mass": 15978.0, "length": 144, "protein_name": "Testis-specific protein TSX", "gene_name": "Tsx", "organism": "Mouse", "refseq_name": "testis-specific protein TSX", "refseq_ac": [ { "id": "NP_033466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033466", "type": "external" } ], "gene_names_uniprotkb": "Tsx", "gene_names_refseq": "Tsx", "protein_names_uniprotkb": "Testis-specific protein TSX", "protein_names_refseq": "testis-specific X-linked protein; testis-specific protein TSX", "tax_id": 10090, "disease": "", "pathway": " (mmu:22127)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21912526;31219806;8922998", "class_list": "", "function": "May have an RNA/DNA binding role., [UniProtKB]; Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0009566 fertilization;GO:0030534 adult behavior;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70675-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70691-1", "uniprot_id": [ { "id": "UD12_MOUSE", "url": "https://www.uniprot.org/uniprot/P70691", "type": "external" } ], "mass": 60285.0, "length": 533, "protein_name": "UDP-glucuronosyltransferase 1-2", "gene_name": "Ugt1a2", "organism": "Mouse", "refseq_name": "UDP-glucuronosyltransferase 1-2 precursor", "refseq_ac": [ { "id": "NP_038729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038729", "type": "external" } ], "gene_names_uniprotkb": "Ugt1a2; Ugt1", "gene_names_refseq": "UDPGT 1-2; Ugt1a2; Ugt1", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 1-2; 2.4.1.17; Bilirubin-specific UDPGT; UDP-glucuronosyltransferase 1A2; UDPGT 1-2; UGT1*2; UGT1-02; UGT1.2; UGT1A2", "protein_names_refseq": "UDP-glucuronosyltransferase 1 family, member 2; UDP-glucuronosyltransferase 1-2 precursor; UDP-glucuronosyltransferase 1-2; UDP-glucuronosyltransferase 1A2; UDPGT; UGT1*0; UGT1-02; UGT1.2; bilirubin specific; bilirubin-specific UDPGT", "tax_id": 10090, "disease": "", "pathway": " (mmu:22236); (R-MMU-156588); (R-MMU-189483); (R-MMU-9749641); (R-MMU-9754706); (R-MMU-9757110)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "12644700;14672974;21383159;35820727;7677729", "class_list": "glycogene;glycosyltransferase", "function": "In addition to the extensively studied tapasin-mediated quality control mechanism, UGT1 adds a new level of control in the MHC class I antigen presentation pathway., [RefSeq, PubMed]; Induced in transgenic mice, functions to eliminate steroids, heme metabolites and environmental toxins, [RefSeq, PubMed]; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 62, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q545X2;Q6XL49", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" }, { "id": "2.4.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.170", "type": "external" }, { "id": "2.4.1.185", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.185", "type": "external" } ], "go_molecular_function": "GO:0008194 UDP-glycosyltransferase activity;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001889 liver development;GO:0016125 sterol metabolic process;GO:0071385 cellular response to glucocorticoid stimulus;GO:0051552 flavone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70691-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97931-1", "uniprot_id": [ { "id": "UNG_MOUSE", "url": "https://www.uniprot.org/uniprot/P97931", "type": "external" } ], "mass": 33926.0, "length": 306, "protein_name": "Uracil-DNA glycosylase", "gene_name": "Ung", "organism": "Mouse", "refseq_name": "uracil-DNA glycosylase isoform a", "refseq_ac": [ { "id": "NP_001035781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035781", "type": "external" } ], "gene_names_uniprotkb": "Ung; UNG1; UNG; Ung1", "gene_names_refseq": "UNG1; UNG2; Ung", "protein_names_uniprotkb": "Uracil-DNA glycosylase; 3.2.2.27; UDG", "protein_names_refseq": "UDG; uracil-DNA glycosylase isoform a", "tax_id": 10090, "disease": "immunodeficiency with hyper IgM type 5 (Disease Ontology:DOID:0060759); dysgammaglobulinemia (Disease Ontology:DOID:11702)", "pathway": " (mmu:22256); (R-MMU-110329); (R-MMU-110357)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10871356;12401169;16103411;21151102;21183079;21750661;22521144;31219806;34819670;38000394;9016624;9168124", "class_list": "", "function": "Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation., [RefSeq, PubMed]; RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork., [RefSeq, PubMed]; Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil residues arising as a result of misincorporation of dUMP residues by DNA polymerase during replication or due to spontaneous or enzymatic deamination of cytosine (PubMed:22521144, PubMed:9016624). Mediates error-free base excision repair (BER) of uracil at replication forks. According to the model, it is recruited by PCNA to S-phase replication forks to remove misincorporated uracil at U:A base mispairs in nascent DNA strands. Via trimeric RPA it is recruited to ssDNA stretches ahead of the polymerase to allow detection and excision of deaminated cytosines prior to replication. The resultant AP sites temporarily stall replication, allowing time to repair the lesion (By similarity). Mediates mutagenic uracil processing involved in antibody affinity maturation. Processes AICDA-induced U:G base mispairs at variable Ig regions leading to the generation of transversion mutations (PubMed:12401169, PubMed:21151102). Additionally, it operates at switch sites of Ig constant regions where it mediates Ig isotype class switch recombination. Excises AICDA-induced uracil residues forming AP sites that are subsequently nicked by APEX1 endonuclease. The accumulation of staggered nicks in opposite strands results in double strand DNA breaks that are finally resolved via non-homologous end joining repair pathway (PubMed:12401169, PubMed:16103411, PubMed:21151102)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97285;P97509;Q7TPW8;Q9JIW8", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.2.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.27", "type": "external" } ], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0043024 ribosomal small subunit binding;GO:0004844 uracil DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0006284 base-excision repair;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0045190 isotype switching", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P97931-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P99031-1", "uniprot_id": [ { "id": "ULAK_MOUSE", "url": "https://www.uniprot.org/uniprot/P99031", "type": "external" } ], "mass": 1109.0, "length": 9, "protein_name": "Unknown protein from spot 2D-0014LD of 2D-PAGE of liver tissue", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot 2D-0014LD of 2D-PAGE of liver tissue", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P99031-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P99032-1", "uniprot_id": [ { "id": "ULAL_MOUSE", "url": "https://www.uniprot.org/uniprot/P99032", "type": "external" } ], "mass": 1327.0, "length": 12, "protein_name": "Unknown protein from spot 2D-0014M9 of 2D-PAGE of liver tissue", "gene_name": "", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Unknown protein from spot 2D-0014M9 of 2D-PAGE of liver tissue", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P99032-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q14DL0-1", "uniprot_id": [ { "id": "UBQLN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q14DL0", "type": "external" } ], "mass": 67566.0, "length": 610, "protein_name": "Ubiquilin-like protein", "gene_name": "Ubqlnl", "organism": "Mouse", "refseq_name": "ubiquilin-like protein", "refseq_ac": [ { "id": "NP_941026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_941026", "type": "external" } ], "gene_names_uniprotkb": "Ubqlnl", "gene_names_refseq": "4922504M18Rik; Gm490; Ubqlnl", "protein_names_uniprotkb": "Ubiquilin-like protein", "protein_names_refseq": "ubiquilin-like protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:244179)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26043068;31219806", "class_list": "", "function": "A testis-specific gene, Ubqlnl, is dispensable for mouse embryonic development and spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9QM12;Q14DR8;Q8BVT0", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q14DL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q283N4-1", "uniprot_id": [ { "id": "URAD_MOUSE", "url": "https://www.uniprot.org/uniprot/Q283N4", "type": "external" } ], "mass": 20017.0, "length": 178, "protein_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "gene_name": "Urad", "organism": "Mouse", "refseq_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "refseq_ac": [ { "id": "NP_001034767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034767", "type": "external" } ], "gene_names_uniprotkb": "Urad; Prhoxnb", "gene_names_refseq": "EG231903; Prhoxnb; Urad", "protein_names_uniprotkb": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 4.1.1.97; OHCU decarboxylase; Parahox neighbor; Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase", "protein_names_refseq": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; parahox cluster neighbor; parahox neighbor; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase", "tax_id": 10090, "disease": "", "pathway": " (mmu:231903)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16462750;34428180", "class_list": "", "function": "Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation., [UniProtKB, PubMed]; Identified as the gene encoding the enzyme catalyzing the third step of the pathway from uric acid to S-allantoin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.97", "type": "external" } ], "go_molecular_function": "GO:0016831 carboxy-lyase activity;GO:0051997 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019628 urate catabolic process;GO:0006144 purine nucleobase metabolic process;GO:0000255 allantoin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q283N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3U3Q1-1", "uniprot_id": [ { "id": "ULK3_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3U3Q1", "type": "external" } ], "mass": 53572.0, "length": 472, "protein_name": "Serine/threonine-protein kinase ULK3", "gene_name": "Ulk3", "organism": "Mouse", "refseq_name": "serine/threonine-protein kinase ULK3", "refseq_ac": [ { "id": "NP_082171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082171", "type": "external" } ], "gene_names_uniprotkb": "Ulk3", "gene_names_refseq": "1200015E14Rik; Ulk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK3; 2.7.11.1; Unc-51-like kinase 3", "protein_names_refseq": "serine/threonine-protein kinase ULK3", "tax_id": 10090, "disease": "", "pathway": " (mmu:71742); (R-MMU-5632684)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20643644;21750661;35820727", "class_list": "", "function": "Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway., [RefSeq, PubMed]; Serine/threonine protein kinase that acts as a regulator of smoothened signaling and autophagy. Acts as a positive regulator of smoothened signaling in the presence of hedgehog (DHH, IHH or SHH) ligand: autophosphorylates and mediates phosphorylation of full-length GLI2, promoting subsequent phosphorylation by CDK1 and GLI2 dissociation from SUFU and translocation to the nucleus. Also phosphorylates as GLI1 and GLI3, although less efficiently. In the absence of hedgehog ligand, interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RXB9;Q8K1X6;Q9DBR8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.26.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3U3Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ULM6-1", "uniprot_id": [ { "id": "USPL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q3ULM6", "type": "external" } ], "mass": 118390.0, "length": 1089, "protein_name": "SUMO-specific isopeptidase USPL1", "gene_name": "Uspl1", "organism": "Mouse", "refseq_name": "SUMO-specific isopeptidase USPL1 isoform C", "refseq_ac": [ { "id": "NP_001013396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013396", "type": "external" } ], "gene_names_uniprotkb": "Uspl1", "gene_names_refseq": "E430026A01Rik; Uspl1", "protein_names_uniprotkb": "SUMO-specific isopeptidase USPL1; 3.4.22.-; Ubiquitin-specific peptidase-like protein 1", "protein_names_refseq": "SUMO-specific isopeptidase USPL1 isoform C; SUMO-specific isopeptidase USPL1; ubiquitin-specific peptidase-like protein 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:231915)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21750661;25428506;30084848", "class_list": "", "function": "SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (By similarity). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0P689;Q3TT12;Q3V2W0;Q5RJG8;Q8BHR4", "ec_number_list": [], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0032183 SUMO binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0015030 Cajal body", "go_biological_process": "GO:0009301 snRNA transcription;GO:0006508 proteolysis;GO:0008283 cell population proliferation;GO:0030576 Cajal body organization;GO:0001825 blastocyst formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3ULM6-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G0F8-1", "uniprot_id": [ { "id": "UBN1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q4G0F8", "type": "external" } ], "mass": 122336.0, "length": 1135, "protein_name": "Ubinuclein-1", "gene_name": "Ubn1", "organism": "Mouse", "refseq_name": "ubinuclein-1 isoform 1", "refseq_ac": [ { "id": "NP_080942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080942", "type": "external" } ], "gene_names_uniprotkb": "Ubn1", "gene_names_refseq": "1110029L11Rik; 2610108L02Rik; Ubn1", "protein_names_uniprotkb": "Ubinuclein-1; Ubiquitously expressed nuclear protein", "protein_names_refseq": "ubinuclein-1 isoform 1; ubiquitously expressed nuclear protein", "tax_id": 10090, "disease": "", "pathway": " (mmu:170644); (R-MMU-2559584)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18823282;21750661;22517741;22645316;25428506;30285846;40885482", "class_list": "", "function": "Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly (By similarity)., [UniProtKB]; In mouse epithelia, including bile canaliculi, bronchioli, salivary gland ducts, and oral and olfactory epithelium, ubinuclein co-localized with tight junction markers, [RefSeq, PubMed]; This study demonstrates that the UBN1 or UBN2 subunit is mainly responsible for specific recognition and direct binding of H3.3 by the HIRA complex. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3UUZ4;Q6P9K7;Q8BNC3;Q9CRM4;Q9CS40", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005923 bicellular tight junction;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q4G0F8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DID3-1", "uniprot_id": [ { "id": "UROL1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DID3", "type": "external" } ], "mass": 145320.0, "length": 1319, "protein_name": "Uromodulin-like 1", "gene_name": "Umodl1", "organism": "Mouse", "refseq_name": "uromodulin-like 1 precursor", "refseq_ac": [ { "id": "NP_803416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803416", "type": "external" } ], "gene_names_uniprotkb": "Umodl1", "gene_names_refseq": "D17Ertd488e; Umodl1", "protein_names_uniprotkb": "Uromodulin-like 1; Olfactorin", "protein_names_refseq": "olfactorin; uromodulin-like 1 precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:52020)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;15682396;16026467;21750661;23190605;30084848", "class_list": "", "function": "At age 3 weeks, Umodl1 (N8) mRNA shows a smooth gradation from high apical to low basal within the layer of mature olfactory sensory neuron layer of the mouse olfactory epithelium. Whether this is due to cell position or cell age is not known., [RefSeq, PubMed]; Overexpression of Umodl1 accelerates follicle depletion and subsequent ovarian degeneration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 8, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 9737, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "Q5DID1;Q5DID2", "ec_number_list": [], "go_molecular_function": "GO:0030414 peptidase inhibitor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:2000354 regulation of ovarian follicle development;GO:0060612 adipose tissue development;GO:0007338 single fertilization;GO:0042981 regulation of apoptotic process;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5DID3-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5DTH5-1", "uniprot_id": [ { "id": "TSH1_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5DTH5", "type": "external" } ], "mass": 118567.0, "length": 1084, "protein_name": "Teashirt homolog 1", "gene_name": "Tshz1", "organism": "Mouse", "refseq_name": "teashirt homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_001074769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074769", "type": "external" } ], "gene_names_uniprotkb": "Tshz1; Kiaa4206; Sdccag33; Tsh1", "gene_names_refseq": "5730407I04Rik; D18Bwg1409e; Mtsh1; NY-CO-33; Sdccag33; Tsh1; Tshz1; teashirt1", "protein_names_uniprotkb": "Teashirt homolog 1; Serologically defined colon cancer antigen 3 homolog", "protein_names_refseq": "serologically defined colon cancer antigen 3 homolog; serologically defined colon cancer antigen 33; teashirt homolog 1 isoform 1; teashirt homolog 1", "tax_id": 10090, "disease": "", "pathway": " (mmu:110796)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10704881;14973285;17586487;19343227;19745106;21750661;34428180", "class_list": "", "function": "Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)., [UniProtKB]; Three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PE60;Q8VD19;Q9JLD5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0042474 middle ear morphogenesis;GO:0060023 soft palate development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5DTH5-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWH2-3", "uniprot_id": [ { "id": "UNKL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5FWH2", "type": "external" } ], "mass": 79636.0, "length": 727, "protein_name": "Putative E3 ubiquitin-protein ligase UNKL", "gene_name": "Unkl", "organism": "Mouse", "refseq_name": "putative E3 ubiquitin-protein ligase UNKL isoform 1", "refseq_ac": [ { "id": "NP_001183953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183953", "type": "external" } ], "gene_names_uniprotkb": "Unkl", "gene_names_refseq": "1300004G08Rik; Unkl", "protein_names_uniprotkb": "Putative E3 ubiquitin-protein ligase UNKL; 2.3.2.-; RING finger protein unkempt-like", "protein_names_refseq": "putative E3 ubiquitin-protein ligase UNKL isoform 1; putative E3 ubiquitin-protein ligase UNKL", "tax_id": 10090, "disease": "", "pathway": " (mmu:74154); (R-MMU-983168)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "20148946;22517741;22645316;32782141;32848054;34678516;35822049;36852467;40021952;40885482", "class_list": "", "function": "May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6RUT6;Q9DBK4", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5FWH2-3", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5SSI6-1", "uniprot_id": [ { "id": "UTP18_MOUSE", "url": "https://www.uniprot.org/uniprot/Q5SSI6", "type": "external" } ], "mass": 61218.0, "length": 552, "protein_name": "U3 small nucleolar RNA-associated protein 18 homolog", "gene_name": "Utp18", "organism": "Mouse", "refseq_name": "U3 small nucleolar RNA-associated protein 18 homolog", "refseq_ac": [ { "id": "NP_001013393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013393", "type": "external" } ], "gene_names_uniprotkb": "Utp18; Wdr50", "gene_names_refseq": "6230425C22Rik; 6430513M13; Utp18; Wdr50", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 18 homolog; WD repeat-containing protein 50", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 18 homolog; UTP18, small subunit (SSU) processome component, homolog; WD repeat domain 50; WD repeat-containing protein 50", "tax_id": 10090, "disease": "", "pathway": " (mmu:217109); (R-MMU-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17242355;17622165;18630941;19131326;19144319;21183079;25428506;30084848;31599954;34428180;34887587;40997131", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034388 Pwp2p-containing subcomplex of 90S preribosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5SSI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62348-1", "uniprot_id": [ { "id": "TSN_MOUSE", "url": "https://www.uniprot.org/uniprot/Q62348", "type": "external" } ], "mass": 26201.0, "length": 228, "protein_name": "Translin", "gene_name": "Tsn", "organism": "Mouse", "refseq_name": "translin", "refseq_ac": [ { "id": "NP_035780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035780", "type": "external" } ], "gene_names_uniprotkb": "Tsn", "gene_names_refseq": "2610034C24Rik; C3PO; TB-RBP; Tsn", "protein_names_uniprotkb": "Translin; 3.1.-.-; C3PO; Component 3 of promoter of RISC; TB-RBP; Testis/brain RNA-binding protein", "protein_names_refseq": "component 3 of promoter of RISC; testis/brain-RNA-binding protein; translin", "tax_id": 10090, "disease": "", "pathway": " (mmu:22099); (R-MMU-426486)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10025964;12079346;12542794;15491149;18250455;25153642;25428506;25428507;25605945;31219806;32408014;33172471;33268667;34428180;36210013;37507081;37828378;9244443", "class_list": "", "function": "DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots., [UniProtKB, PubMed]; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand., [UniProtKB, PubMed]; Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation., [RefSeq, PubMed]; Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion., [RefSeq, PubMed]; Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity. Erratum:[Mol Brain. 2021 Mar 5;14(1):48. doi: 10.1186/s13041-021-00761-2. PMID: 33673835] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.26.n2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.n2", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:1902555 endoribonuclease complex", "go_biological_process": "GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q62348-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69AB2-1", "uniprot_id": [ { "id": "TXND8_MOUSE", "url": "https://www.uniprot.org/uniprot/Q69AB2", "type": "external" } ], "mass": 14517.0, "length": 127, "protein_name": "Thioredoxin domain-containing protein 8", "gene_name": "Txndc8", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Txndc8; Sptrx3; Trx6", "gene_names_refseq": "", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 8; Spermatid-specific thioredoxin-3; Sptrx-3; Thioredoxin-6", "protein_names_refseq": "", "tax_id": 10090, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (mmu:67402)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15181017;15781233;21750661", "class_list": "", "function": "May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78Y03;Q80YE0;Q9CQ96", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q69AB2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6J9-1", "uniprot_id": [ { "id": "TXD15_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6P6J9", "type": "external" } ], "mass": 38146.0, "length": 344, "protein_name": "Thioredoxin domain-containing protein 15", "gene_name": "Txndc15", "organism": "Mouse", "refseq_name": "thioredoxin domain-containing protein 15 precursor", "refseq_ac": [ { "id": "NP_780359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780359", "type": "external" } ], "gene_names_uniprotkb": "Txndc15", "gene_names_refseq": "2310047H23Rik; C5orf14; Txndc15; UNQ335", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 15", "protein_names_refseq": "disulfide isomerase; thioredoxin domain-containing protein 15 precursor; thioredoxin domain-containing protein 15", "tax_id": 10090, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778)", "pathway": " (mmu:69672)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1101/2023.09.13.557529;19349973;29459677;30084848;30899004;34428180", "class_list": "", "function": "Acts as a positive regulator of ciliary hedgehog signaling (PubMed:29459677). Required for cilia biogenesis (PubMed:29459677)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9015, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q52KM6;Q8BV80;Q8K319", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q6P6J9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000100000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R653-1", "uniprot_id": [ { "id": "UN5CL_MOUSE", "url": "https://www.uniprot.org/uniprot/Q6R653", "type": "external" } ], "mass": 57956.0, "length": 518, "protein_name": "UNC5C-like protein", "gene_name": "Unc5cl", "organism": "Mouse", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Unc5cl; Zud", "gene_names_refseq": "", "protein_names_uniprotkb": "UNC5C-like protein; Protein unc-5 homolog C-like; ZU5 and death domain-containing protein", "protein_names_refseq": "", "tax_id": 10090, "disease": "", "pathway": " (mmu:76589)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14769797;21750661;30084848", "class_list": "", "function": "Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3UMF8;Q501N0;Q8BTQ8;Q8BYF7;Q8C1L0;Q8K3C8", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6R653-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q710D3-1", "uniprot_id": [ { "id": "UN93A_MOUSE", "url": "https://www.uniprot.org/uniprot/Q710D3", "type": "external" } ], "mass": 50370.0, "length": 458, "protein_name": "N-acetylglucosamine transporter UNC93A", "gene_name": "Unc93a", "organism": "Mouse", "refseq_name": "protein unc-93 homolog A", "refseq_ac": [ { "id": "NP_954860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954860", "type": "external" } ], "gene_names_uniprotkb": "Unc93a", "gene_names_refseq": "Unc93a; Unc93l; unc-93A", "protein_names_uniprotkb": "N-acetylglucosamine transporter UNC93A; Protein unc-93 homolog A; Unc-93A", "protein_names_refseq": "protein unc-93 homolog A; unc93 homolog A", "tax_id": 10090, "disease": "", "pathway": " (mmu:381058)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically transports N-acetylglucosamine across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015572 N-acetylglucosamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q710D3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q765I1-1", "uniprot_id": [ { "id": "UTS2B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q765I1", "type": "external" } ], "mass": 12821.0, "length": 113, "protein_name": "Urotensin-2B", "gene_name": "Uts2b", "organism": "Mouse", "refseq_name": "urotensin-2B precursor", "refseq_ac": [ { "id": "NP_937809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937809", "type": "external" } ], "gene_names_uniprotkb": "Uts2b; Urp; Uts2d", "gene_names_refseq": "Gm538; U2B; Urp; Uts2b; Uts2d", "protein_names_uniprotkb": "Urotensin-2B; U-IIB; UIIB; Urotensin II-related peptide; Urotensin IIB; Urotensin-2 domain-containing protein", "protein_names_refseq": "U-IIB; UIIB; urotensin II-related peptide; urotensin IIB; urotensin-2 domain-containing protein; urotensin-2B precursor", "tax_id": 10090, "disease": "", "pathway": " (mmu:224065); (R-MMU-375276); (R-MMU-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "14550283;16125650;35390674", "class_list": "", "function": "Novel hypothalamic neuroendocrine peptide co-localized and possible co-released with gonadotropin releasing hormone, [RefSeq, PubMed]; Potent vasoconstrictor., [UniProtKB]; URP is the endogenous and functional ligand for UII receptor in the mouse, [RefSeq, PubMed]; Uts2b is a microbiota-regulated gene expressed in vagal afferent neurons connected to enteroendocrine cells producing cholecystokinin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0008217 regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q765I1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMI3-1", "uniprot_id": [ { "id": "UHRF2_MOUSE", "url": "https://www.uniprot.org/uniprot/Q7TMI3", "type": "external" } ], "mass": 90106.0, "length": 803, "protein_name": "E3 ubiquitin-protein ligase UHRF2", "gene_name": "Uhrf2", "organism": "Mouse", "refseq_name": "E3 ubiquitin-protein ligase UHRF2 isoform 1", "refseq_ac": [ { "id": "NP_659122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659122", "type": "external" } ], "gene_names_uniprotkb": "Uhrf2; Nirf", "gene_names_refseq": "2310065A22Rik; D130071B19Rik; Nirf; Uhrf2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF2; 2.3.2.27; NIRF; Np95-like ring finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2", "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF2 isoform 1; E3 ubiquitin-protein ligase UHRF2; Np95-like ring finger protein; RING-type E3 ubiquitin transferase UHRF2; nuclear protein 97; nuclear zinc finger protein Np97; ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like-containing PHD and RING finger domains protein 2", "tax_id": 10090, "disease": "", "pathway": " (mmu:109113); (R-MMU-3899300)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "21183079;21598301;23434322;25428506;28115522;28402695;30084848;34428180;34887587;37253089;38338822", "class_list": "", "function": "E3 Ubiquitin Ligase Uhrf2 Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair. Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695). This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522). Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation. Also promotes DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation. Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8BG56;Q8BJP6;Q8BY30;Q8K1I5", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000792 heterochromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0030154 cell differentiation;GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination;GO:0051726 regulation of cell cycle;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TMI3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000100000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80YF6-1", "uniprot_id": [ { "id": "UPK3B_MOUSE", "url": "https://www.uniprot.org/uniprot/Q80YF6", "type": "external" } ], "mass": 30227.0, "length": 275, "protein_name": "Uroplakin-3b", "gene_name": "Upk3b", "organism": "Mouse", "refseq_name": "uroplakin-3b precursor", "refseq_ac": [ { "id": "NP_780518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780518", "type": "external" } ], "gene_names_uniprotkb": "Upk3b", "gene_names_refseq": "P35; PMS2L14; UpIIIb; Upk3b", "protein_names_uniprotkb": "Uroplakin-3b; UP3b; UPIIIb; Uroplakin IIIb; p35", "protein_names_refseq": "UP3b; uroplakin IIIb; uroplakin-3b precursor; uroplakin-3b", "tax_id": 10090, "disease": "", "pathway": " (mmu:100647)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12446744;21750661;25428506;30084848;34428180", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBK9;Q6P8J5;Q8BGL8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0046325 negative regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80YF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000100000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BL48-1", "uniprot_id": [ { "id": "UNK_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BL48", "type": "external" } ], "mass": 88058.0, "length": 810, "protein_name": "RING finger protein unkempt homolog", "gene_name": "Unk", "organism": "Mouse", "refseq_name": "RING finger protein unkempt homolog isoform 1", "refseq_ac": [ { "id": "NP_766157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766157", "type": "external" } ], "gene_names_uniprotkb": "Unk; Kiaa1753; Zc3h5; Zc3hdc5", "gene_names_refseq": "B230379M23Rik; Unkh; Unk; Zc3h5; Zc3hdc5; mKIAA1753", "protein_names_uniprotkb": "RING finger protein unkempt homolog; Zinc finger CCCH domain-containing protein 5", "protein_names_refseq": "RING finger protein unkempt homolog isoform 1; RING finger protein unkempt homolog; zinc finger CCCH domain-containing protein 5; zinc finger CCCH type containing 5; zinc finger CCCH type domain containing 5", "tax_id": 10090, "disease": "", "pathway": " (mmu:217331)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21183079;25737280;36509146", "class_list": "", "function": "Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis., [RefSeq, PubMed]; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2A853;Q8BVI6;Q99JZ8;Q99LL9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043022 ribosome binding;GO:1990715 mRNA CDS binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001764 neuron migration;GO:0048667 cell morphogenesis involved in neuron differentiation;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8BL48-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000100000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8BUB6-1", "uniprot_id": [ { "id": "UST_MOUSE", "url": "https://www.uniprot.org/uniprot/Q8BUB6", "type": "external" } ], "mass": 47730.0, "length": 407, "protein_name": "Uronyl 2-sulfotransferase", "gene_name": "Ust", "organism": "Mouse", "refseq_name": "uronyl 2-sulfotransferase", "refseq_ac": [ { "id": "NP_796361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796361", "type": "external" } ], "gene_names_uniprotkb": "Ust", "gene_names_refseq": "D930010O20Rik; UA2OST; Ust", "protein_names_uniprotkb": "Uronyl 2-sulfotransferase; 2.8.2.-", "protein_names_refseq": "uronyl 2-sulfotransferase", "tax_id": 10090, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (mmu:338362); (R-MMU-2022870); (R-MMU-2022923)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10.1101/2023.09.13.557529;18819920;28107390;35820727", "class_list": "glycogene", "function": "Analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST), [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to the 2-OH position of uronyl residues in glycosaminoglycan chains. Has mainly activity toward iduronyl residues in dermatan sulfate, and toward glucuronyl residues of chondroitin sulfate. Has little to no activity toward desulfated N-resulfated heparin or N-sulfoheparosan., [UniProtKB, UniProtKB]; This is the first study showing that Ust, and consequently 2-O sulfation of the low affinity receptor for FgfR CS/DS, reduces Itga5 and leads to an impaired adhesion and migration of melanoma cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 16, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B2RR02", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0034482 chondroitin 2-sulfotransferase activity;GO:0102142 dermatan 2-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0030010 establishment of cell polarity;GO:0050651 dermatan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8BUB6-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000100000.1000000000000.100.10000", "kg_view_protein": true } ]